The therapeutic prospect of crosstalk between prokaryotic and eukaryotic organisms in the human gut

Abstract

The peaceful phenomena of the co-evolution between the prokaryotes (microbiota) and the eukaryotes (parasites including protozoa and helminths) in the animal gut have drawn the researchers attention. Importantly, exploring the potential using of helminths for therapeutic use was one of the reasons behind understanding the physiological and immunological cross talk existing between them. Here we discussed the interactive immunological associations of helminths and microbial responses individually and in combination with their hosts. Considered that there is probable being a cross talk between eukaryotic organism like helminths and protozoa with their host's gut microbiota, in this review, we searched the literature identifying the privileged and favorable relation generated between the two in the host. This understanding of possibilities of the role of helminths along with the gut microbiota as a black box would certainly decode the therapeutic intrusion with helminths in experimental clinical trials and a successful trial can be used to considering for possible futuristic and safe treatments for various immune-inflammatory diseases of humans.

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