The number and affinity of productive IgE pairs determine allergen activation of mast cells

Publication date: Available online 4 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Charlotte Hjort, Peter Oluf Schiøtz, Mats Ohlin, Peter Adler Würtzen, Lars Harder Christensen, Hans Jürgen Hoffmann

Teaser

IgE composition (number and concentration of IgE pairs, IgE clonality, and IgE affinity) determines number of mast cells reacting and allergen threshold for activation and may dictate the threshold allergen dose and severity of allergy symptoms in the individual allergic patient.


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