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Τετάρτη 26 Ιουνίου 2019

Researchers Identify Potential Modifier Genes in Patients with Charcot-Marie-Tooth Disease
“Modifier studies offer a significant pathway to additional therapeutic target discovery and underscore that monogenic disorders are a lot more complex than previously thought,” explained lead investigator Stephan Züchner, MD, PhD, of the Department of Human Genetics and Hussman Institute for Human Genomics of the University of Miami, USA. “Our study is a first in CMT, and one of the largest in all of rare diseases, to explore – genome wide and unbiased – the correlation of clinical outcome and genetic...
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Moral Emotions, a Diagnostic Tool for Frontotemporal Dementia?
Frontotemporal dementia is a cognitive and behavioral disease caused by degenerative alteration of anterior regions of the brain. The disease is characterized by behavioral disorders such as a progressive apathy, loss of interest, social withdrawal, loss of inhibition and the processing of emotions. “We have known for a long time that these patients demonstrate impairment of emotion recognition and of theory of mind i.e. the ability to figure out the mental states of others: what they think, what...
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Specific Multinutrient Combination Benefits Patients with Early Stage Alzheimer’s Disease
The purpose of this study was to assess whether this multinutrient combination can benefit patients with mild cognitive impairment who are at risk of progressing to the dementia stage of AD. Previous studies have shown that Fortasyn Connect® can have benefits in early AD. “The initial asymptomatic phase (preclinical AD) continues into a prodromal phase with mild but noticeable cognitive impairment, yet with functional autonomy, with eventual further progression to dementia. This gradual progression...
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Opioid Analgesics Increase the Risk of Pneumonia Among Persons with Alzheimer’s Disease
The risk of pneumonia was highest among those using strong opioids, such as oxycodone or fentanyl, but the risk was also increased among those using buprenorphine, tramadol or codeine. Persons with active cancer were excluded from the study, and other diseases and drug use were accounted for in the analyses. Opioids impair the cough reflex and respiratory functions and cause sedation, possibly underlying the increased risk for pneumonia. Pneumonia is a severe but relatively common complication among...
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Agriculture and Environment Perspectives in Intelligent Systems
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Antihypertensive Drug Use Associated with a Decreased Dementia Risk in Almost 25,000 Elderly Persons Followed in General Practices in Germany
The goal of the present study, which will be published in an upcoming issue of the Journal of Alzheimer’s Disease, was to investigate the relationship between antihypertensive drug use and dementia in elderly persons followed in general practices in Germany. “After another setback for the anti-amyloid strategy, dementia prevention is increasingly becoming an area of interest,” explains Dr. Jens Bohlken, MD, PhD, from the Institute of Social Medicine, Occupational Health and Public Health (ISAP)...
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Hearing Through Your Fingers: Device that Converts Speech to Touch Enables the Hearing-Impaired to Hear Through Their Fingertips
“Despite recent advancements in hearing aid and cochlear implants, the most widespread surgical implant to restore audition, hearing-impaired users still encounter significant practical and social challenges with or without aids,” explained lead investigator Amir Amedi, PhD, Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Ein-Kerem, and The Cognitive Science Program, The Hebrew University of Jerusalem,...
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