Abstract Objectives The clinical utility of conventional IV opioids is limited by the occurrence of opioid‐related adverse events. Oliceridine is a novel G protein–biased μ‐opioid receptor agonist designed to provide analgesia with an improved safety and tolerability profile. This phase III, double‐blind, randomized trial (APOLLO‐2 [NCT02820324]) evaluated the efficacy and safety of oliceridine for acute pain following abdominoplasty. Methods Patients received a loading dose of either placebo,...
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Abstract Introduction Topical capsaicin is commonly employed to experimentally induce central sensitization (CS) in humans. While previous studies have investigated the effect of skin pre‐heating on the sensitizing effect of capsaicin, no studies have compared the synergistic effect of skin pre‐heating on the magnitude of sensitization via topical capsaicin within the first 30 minutes of application. We tested the hypothesis that skin pre‐heating potentiates the sensitizing effect of topical...
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Abstract Aim Paravertebral ozone injection is a new treatment method described in the literature for low back pain. The aim of this study was to compare the pre‐ and post‐treatment pain scores of patients undergoing paravertebral O3/O2 (ozone‐oxygen) injections for low back pain. Methods From September 2018 to December 2018, 122 patients who underwent paravertebral ozone injections due to low back pain were examined retrospectively; 62 patients who met the study criteria were included....
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Abstract Objective This case report presents an application of percutaneous peripheral nerve stimulation to the right superficial peroneal nerve to treat a patient with chronic intractable L5‐S1 radiculopathy pain that conventional treatment failed to ameliorate. Methods The patient underwent an uneventful implantation of a percutaneous peripheral nerve stimulator. The implanted lead (15cm in length and 1.2mm in diameter) containing the receiver coil and three stimulation electrodes (Bioness...
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Abstract Background Sensitivity‐related trait characteristics involving physical and emotional sensitivities and high trait anxiety personality types have been observed in individuals with non‐specific chronic low back pain (NSCLBP). High trait sensitivity to sensory stimulation combined with interpretation biases based on personality type may contribute to the development of central sensitisation (CS) symptoms. To date there is limited research that has considered both sensitivity levels and...
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Abstract A 70‐year‐old woman visited our hospital for evaluation of dull pain over 3‐4 weeks on the radial side of her right wrist. To visualize the lesion, an ultrasound (10‐MHz linear probe) was performed. A well‐defined, 1.0 × 0.8 × 1.6 cm, fusiform cystic lesion with prominent compressible and hypoechoic rim caused by peritendinous effusion inside the tendon sheath of the right 1st dorsal extensor compartment was noted around the base of the thumb on the transverse and longitudinal images (Figure...
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Abstract Background This review discusses the findings in the literature on pain and distraction tasks according to their sensory modality. Distraction tasks have been shown to reduce (experimentally induced) acute pain and chronic pain. This can be influenced by nature and by the sensory modalities used in the distraction tasks. Yet the effect on reducing pain according to the sensory modality of the distraction task has received little attention. Methods A bibliographic search was performed...
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Abstract Background Patients with chronic pain treated with opioids are at an increased risk for opioid misuse or opioid use disorder (OUD). Recent years have seen a stark increase in abuse, misuse, and diversion of prescription opioid medications. The aim of this study was to investigate trends in changing rates of opioid use disorder among patients with chronic pain. Methods The National Inpatient Sample (NIS) database identified chronic pain admissions with OUD from 2011 to 2015. Patients...
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Abstract Objectives The aim of this study was to determine if any of the factors recorded on a standard clinical history of a patient considered for spinal cord stimulation (SCS) would be associated with reduction or cessation of opioids following implantation. Design Retrospective, single academic center. Materials and Methods Patient included in the chart analysis were implanted with percutaneous SCS devices from 1999‐2015 with follow up until the end of September 2018. Patients...
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Abstract Background Chronic abdominal pain can be due to entrapped intercostal nerves (anterior cutaneous nerve entrapment syndrome, ACNES). If abdominal wall infiltration using an anesthetic agent is unsuccessful, a neurectomy may be considered. Pulsed Radiofrequency (PRF) applies an electric field around the tip of the cannula near the affected nerve to induce pain relief. Only limited retrospective evidence suggests that PRF is effective in ACNES. Methods A multicenter, randomized, non‐blinded,...
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Abstract Objectives Multidisciplinary pain management programmes (PMPs) were established in the 1970s and are widely regarded as the gold standard management for people with chronic, non‐cancer pain. However, the recommended content of PMPs is not well described. The aim of the study was to determine the most common content and structure of inpatient PMPs, and describe how these have changed over time. Methods A mapping review was performed of studies incorporating an inpatient PMP. Information...
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Abstract Purpose To investigate whether people with chronic low back pain (LBP) show dysfunctional exercise induced hypoalgesia (EIH) in response to repeated contractions of their back muscles during a lifting task. Methods In this cross‐sectional observational study conducted on asymptomatic participants (n=18) and participants with chronic LBP (n=21), quantitative sensory testing (QST) was applied extensively over the lumbar region and a remote area before and after repeated task which...
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Abstract Background Pain is a common symptom in Parkinson's disease (PD). Objectives to analyze the relationship between pain and motor dysfunction in PD individuals. Methods 54 PD individuals were screened [Hoehn & Yahr=2.5(1‐4); [median(min‐max)], 66(44‐85) years of age in the ON period of the anti‐Parkinson medication. Pain (King's Parkinson's disease pain scale‐KPPS and Brief Pain Inventory‐BPI); performance in routine activities and motor function (Unified Parkinson Disease...
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Abstract Cervical epidural steroid injection (CESI) with local anesthetics is commonly used to treat neck pain and radicular pain of upper extremity. Local anesthetic systemic toxicity (LAST) occurs shortly after injection as a complication; however, delayed onset is a very rare event, especially central nervous system (CNS) block. We present a case in which delayed onset of LAST occurred, in a patient received CESI for cervical and arm radiating pain due to a cervical disc protrusion. We performed...
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