Publication date: Available online 26 June 2019Source: BiomaterialsAuthor(s): Yen-Chun Lu, Tinyi Chu, Matthew S. Hall, Dah-Jiun Fu, Quanming Shi, Alan Chiu, Duo An, Longhai Wang, Yehudah Pardo, Teresa Southard, Charles G. Danko, Jan Liphardt, Alexander Yu Nikitin, Mingming Wu, Claudia Fischbach, Scott Coonrod, Minglin MaAbstractThe physical microenvironment of tumor cells plays an important role in cancer initiation and progression. Here, we present evidence that confinement – a new physical parameter...
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Publication date: Available online 26 June 2019Source: BiomaterialsAuthor(s): Daniel Sanchez-Guzman, Pierre Le Guen, Berengere Villeret, Nuria Sola, Remi Le Borgne, Alice Guyard, Alix Kemmel, Bruno Crestani, Jean-Michel Sallenave, Ignacio Garcia-VerdugoAbstractMost of current influenza virus vaccines fail to develop a strong immunity at lung mucosae (site of viral entry) due to sub-optimal vaccination protocols (e.g. inactivated virus administered by parenteral injections). Mucosal immunity could...
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Publication date: Available online 26 June 2019Source: BiomaterialsAuthor(s): Wenqi Yu, Xueqin He, Zhihang Yang, Xiaotong Yang, Wei Xiao, Rui Liu, Rou Xie, Lin Qin, Huile GaoAbstractRecently, photodynamic therapy (PDT) emerges as a promising way to initiate immune response and being used in combination with chemotherapy. However, the antitumor effect is restricted due to the poor tumor penetration and retention, premature drug release and immunosuppressive environment of tumor sites. And as the size...
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Publication date: Available online 25 June 2019Source: BiomaterialsAuthor(s): Bin Liu, Wenmiao Wang, Jialong Fan, Ying Long, Feng Xiao, Muhammad Daniyal, Chunyi Tong, Qian Xie, Yuqing Jian, Bin Li, Xiaochi Ma, Wei WangAbstractDue to the non-targeted release of anti-cancer agent gamabufotalin (CS-6), conventional chemotherapy using this drug can cause serious side effects, which accordingly result in poor therapeutic efficiency. Recently, the development of smart nanodrug systems has attracted more...
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Publication date: Available online 25 June 2019Source: BiomaterialsAuthor(s): Hua Wang, Yang Bo, Yang Liu, Ming Xu, Kaimin Cai, Ruibo Wang, Jianjun ChengAbstractWe developed glycopolyesters (GPs) via azido-sugar initiated ring-opening polymerization of O-carboxyanhydrides (OCAs) and achieved efficient in vivo cancer targeting via GP-nanoparticle (GP-NP) mediated metabolic cell labeling followed by Click reaction. GP-NP shows controlled release of azido-sugars and can efficiently label LS174T colon...
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Publication date: Available online 25 June 2019Source: BiomaterialsAuthor(s): Jie Li, Rongcui Jiang, Qi Wang, Xiang Li, Xiaoming Hu, Yan Yuan, Xiaomei Lu, Wenjun Wang, Wei Huang, Quli FanAbstractGasotransmitters with their cytotoxicity in high concentration have become the focus of attention. For such concentration depended therapy, how to effectively deliver gases and precisely control gases release to the lesion as well as combine them with other therapy to achieve precise therapeutics is still...
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Publication date: Available online 25 June 2019Source: BiomaterialsAuthor(s): Audrey Gossart, Didier Letourneur, Adeline Gand, Véronique Regnault, Mohamed Amine Ben Mlouka, Pascal Cosette, Emmanuel Pauthe, Véronique Ollivier, J. Paul SanterreAbstractMonocytes are at the crossroads between inflammation and coagulation processes since they can secrete pro-inflammatory cytokines and express tissue factor (TF), a major initiator of coagulation. Cobalt-chrome (CoCr), a metal alloy, used as a biomaterial...
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Publication date: Available online 25 June 2019Source: BiomaterialsAuthor(s): Anna Ju, SungWon Lee, Young Eun Lee, Ki-Cheol Han, Jin-Chul Kim, Sang Chul Shin, Hyun Jung Park, Eunice EunKyeong Kim, Seokmann Hong, Mihue JangAbstractGenetically engineered cells via CRISPR/Cas9 system can serve as powerful sources for cancer immunotherapeutic applications. Furthermore, multiple genetic alterations are necessary to overcome tumor-induced immune-suppressive mechanisms. However, one of the major obstacles...
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Publication date: Available online 24 June 2019Source: BiomaterialsAuthor(s): Yue Zhang, Song Shen, Gui Zhao, Cong-Fei Xu, Hou-Bing Zhang, Ying-Li Luo, Zhi-Ting Cao, Jia Shi, Zhi-Bin Zhao, Zhe-Xiong Lian, Jun WangAbstractOrgan transplantation is the only effective method to treat end-stage organ failure. However, it is continuously plagued by immune rejection, which is mostly caused by T cell-mediated reactions. Dendritic cells (DCs) are professional antigen-presenting cells, and blocking the costimulatory...
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