Cancers, Vol. 11, Pages 890: Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for CancerCancers doi: 10.3390/cancers11070890Authors: Alsereihi Schulten Bakhashab Saini Al-Hejin Hussein Effective diagnostic, prognostic and therapeutic biomarkers can help in tracking disease progress, predict patients’ survival, and considerably affect the drive for successful clinical management. The present...
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Cancers, Vol. 11, Pages 891: Salivary Extracellular Vesicle-Associated exRNA as Cancer BiomarkerCancers doi: 10.3390/cancers11070891Authors: Chiabotto Gai Deregibus CamussiExtracellular vesicles (EVs) secreted in biological fluids contain several transcripts of the cell of origin, which may modify the functions and phenotype of proximal and distant cells. Cancer-derived EVs may promote a favorable microenvironment for cancer growth and invasion by acting on stroma and endothelial cells and may favor...
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Cancers, Vol. 11, Pages 888: Exo-miRNAs as a New Tool for Liquid Biopsy in Lung CancerCancers doi: 10.3390/cancers11060888Authors:Orazio FortunatoPatrizia GaspariniMattia BoeriGabriella SozziLung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs...
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Cancers, Vol. 11, Pages 889: Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the MechanismsCancers doi: 10.3390/cancers11060889Authors:Jacqueline KesslerTim HohmannAntje GüttlerMarina PetrenkoChristian OstheimerUrszula HohmannMatthias BacheFaramarz DehghaniDirk VordermarkThe presence of an isocitrate dehydrogenase 1 (IDH1) mutation is associated with a less aggressive phenotype, increased sensitivity...
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Cancers, Vol. 11, Pages 886: Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of FAM83A and FAM83BCancers doi: 10.3390/cancers11060886Authors:Ling CaiDanni LuoBo YaoDonghan M. YangShinYi LinLuc GirardRalph J. DeBerardinisJohn D. MinnaYang XieGuanghua XiaoIntroduction: In our previous study, we constructed a Lung Cancer Explorer (LCE) database housing lung cancer-specific expression data and clinical data from over 6700 patients in 56 studies....
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Cancers, Vol. 11, Pages 887: Utility of Circulating Cell-Free RNA Analysis for the Characterization of Global Transcriptome Profiles of Multiple Myeloma PatientsCancers doi: 10.3390/cancers11060887Authors:Maoshan ChenSridurga MithraprabhuMalarmathy RamachandranKawa ChoiTiffany KhongAndrew SpencerIn this study, we evaluated the utility of extracellular RNA (exRNA) derived from the plasma of multiple myeloma (MM) patients for whole transcriptome characterization. exRNA from 10 healthy controls (HC),...
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Cancers, Vol. 11, Pages 885: MiRNAs Are Involved in Tall Cell Morphology in Papillary Thyroid CarcinomaCancers doi: 10.3390/cancers11060885Authors:Laura A. BoosAnja SchmittHolger MochPaul KomminothCedric SimillionIlaria MarinoniYuri E. NikiforovMarina N. NikiforovaAurel PerrenMatthias S. DettmerFive percent of papillary thyroid carcinomas (PTC) show an adverse clinical outcome (ACO). The tall cell variant of papillary thyroid carcinomas (TCV) is a good predictor of an ACO, however, the identification...
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Cancers, Vol. 11, Pages 884: Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the OvaryCancers doi: 10.3390/cancers11060884Authors:Matthew DeanVivian JinTova M. BergstenJulia R. AustinDaniel D. LantvitAngela RussoJoanna E. BurdetteHigh-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By...
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Cancers, Vol. 11, Pages 883: Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene ExpressionCancers doi: 10.3390/cancers11060883Authors:Tabea RiedlingerMarek BartkuhnTobias ZimmermannSandra B. HakeAndrea NistThorsten StieweMichael KrachtM. Lienhard SchmitzInhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung...
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Cancers, Vol. 11, Pages 882: Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAsCancers doi: 10.3390/cancers11060882Authors:Azadeh AmirnasrCaroline M.M. GitsPatricia F. van KuijkMarcel SmidAnne L.M. VriendsPiotr RutkowskiRaf SciotPatrick SchöffskiMaria Debiec-RychterStefan SleijferErik A. C. WiemerDespite the success of imatinib in advanced gastrointestinal stromal tumor (GIST) patients, 50% of the patients experience...
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Cancers, Vol. 11, Pages 881: (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma—Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer PrognosisCancers doi: 10.3390/cancers11060881Authors:Maider BeitiaJon Danel Solano-IturriPeio ErrarteJulio Calvete-CandenasAlberto LoizateMari Carmen EtxezarragaBegoña SanzGorka Larrinaga(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling....
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