Characterization of the development of the mouse cochlear epithelium at the single cell level. Nat Commun. 2020 May 13;11(1):2389 Authors: Kolla L, Kelly MC, Mann ZF, Anaya-Rocha A, Ellis K, Lemons A, Palermo AT, So KS, Mays JC, Orvis J, Burns JC, Hertzano R, Driver EC, Kelley MW Abstract Mammalian hearing requires the development of the organ of Corti, a sensory epithelium comprising unique cell types. The limited number of each of these cell types,...
Fri May 15, 2020 13:09
Fusion 68Ga-Prostate-Specific Membrane Antigen PET/MRI on Postoperative Surveillance of Juvenile Nasal Angiofibroma. Clin Nucl Med. 2020 May 11;: Authors: Sakthivel P, Thakar A, Arunraj ST, Bhalla AS, Kumar R Abstract Prostate-specific membrane antigen (PSMA) is expressed universally in juvenile nasopharyngeal angiofibroma (JNA). As contrast enhancement of postoperative scar is common with contrast-enhanced MRI (CEMRI), diagnosis of residual/recurrent...
Fri May 15, 2020 13:09
Application of bilateral supraclavicular artery island flaps in the repair of hypopharyngeal and cervical skin defects: a case report. Chin Med J (Engl). 2020 May 11;: Authors: Zhou J, Ding YM, Zhou MJ, Kuang YX, Ma TY, Chen XH PMID: 32404693 [PubMed - as supplied by publisher]
Fri May 15, 2020 13:09
Targeted molecular imaging of head and neck squamous cell carcinoma: a window into precision medicine. Chin Med J (Engl). 2020 May 11;: Authors: Wu J, Yuan Y, Tao XF Abstract Tumor biomarkers play important roles in tumor growth, invasion, and metastasis. Imaging of specific biomarkers will help to understand different biological activities, thereby achieving precise medicine for each head and neck squamous cell carcinoma (HNSCC) patient. Here, we...
Fri May 15, 2020 13:09
Hypogeusia as the initial presenting symptom of COVID-19. BMJ Case Rep. 2020 May 13;13(5): Authors: Melley LE, Bress E, Polan E Abstract COVID-19 is the disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first arose in Wuhan, China, in December 2019 and has since been declared a pandemic. The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory...
Fri May 15, 2020 13:09
Spontaneous transethmoidal meningoencephalocele presenting in the form of recurrent unilateral nasal discharge: discussion of the diagnosis and endoscopic surgical management. BMJ Case Rep. 2020 May 13;13(5): Authors: Hallak B, Kurzbuch AR, Fournier JY, Bouayed S Abstract Meningoencephaloceles of the skull base most commonly occur as a sequela of head trauma or they can more rarely be congenital malformations. Several types of encephalocele exist...
Fri May 15, 2020 13:09
Swallowing functional outcomes and nutritional status in head and neck cancer radiotherapy: longitudinal study. BMJ Support Palliat Care. 2020 May 13;: Authors: Wang Y, Zhang L, Jin S, Li H, Gong L, Wang Y, Jin S, Cao Y, Shih Y, Lu Q Abstract OBJECTIVE: To explore the relationships between swallowing functional outcomes and nutritional status in patients with head and neck cancer undergoing radiotherapy (RT). METHODS: This longitudinal...
Fri May 15, 2020 13:09
Resection of carcinoma of the external auditory canal in a patient with a high jugular bulb using temporal craniotomy. Auris Nasus Larynx. 2020 May 10;: Authors: Matsumoto F, Miyakita Y, Sakai A, Akamatsu M, Matsumoto Y, Matsumura S, Omura G, Kobayashi K, Narita Y, Yoshimoto S Abstract External auditory canal (EAC) carcinoma is a rare and unusual malignancy. The complex anatomy and relationship between the tumor and surrounding tissues in a limited...
Fri May 15, 2020 13:09
Osteosarcoma of the jaw: report of 3 cases (including the rare epithelioid variant) with review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May 11;: Authors: Malik F, Gleysteen JP, Agarwal S Abstract Osteosarcoma of the jaw (OSJ) is a rare malignancy, accounting for less than 1% of head and neck malignancies. OSJ can arise as a primary malignancy or secondary to locoregional radiation treatment. Radiologically, these tumors show...
Fri May 15, 2020 13:09
Promoter region mutations of the telomerase reverse transcriptase (TERT) gene in head and neck squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May 11;: Authors: Yilmaz I, Erkul BE, Ozturk Sari S, Issin G, Tural E, Terzi Kaya Terzi N, Karatay H, Celik M, Ulusan M, Bilgic B Abstract OBJECTIVE: The aim of the present study was to assess the prevalence of TERT promoter region mutations in tumor samples of patients with squamous...
Fri May 15, 2020 13:09
Radiation-induced xerostomia in a patient with head and neck cancer treated with Injection of autologous expanded adipose tissue-derived mesenchymal stem cells: A new therapeutic opportunity. Acta Otorrinolaringol Esp. 2020 May 11;: Authors: Coromina Isern J, Soler Rich R, Rius Tarruella J, Zamora Bustamante J PMID: 32404242 [PubMed - as supplied by publisher]
Fri May 15, 2020 13:09
Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction. Mol Med. 2020 May 13;26(1):43 Authors: Li C, Ran H, Song S, Liu W, Zou W, Jiang B, Zhao H, Shao B Abstract BACKGROUND: Radiation therapy is the primary method of treatment for glioblastoma (GBM). Therefore, the suppression of radioresistance in GBM cells is of enormous significance. Ribophorin II (RPN2), a protein component of an N-oligosaccharyl...
Fri May 15, 2020 13:09
Computed tomography angiography lightbulb sign: Characteristic enhancement pattern on neck computed tomography angiography in differentiating paraganglioma from schwannoma of the carotid space. Neuroradiol J. 2020 May 14;:1971400920924318 Authors: Suthiphosuwan S, Bai HD, Yu E, Bharatha A Abstract It is important to correctly distinguish paragangliomas from other tumors such as schwannomas in the preoperative assessment of head and neck tumors because...
Fri May 15, 2020 13:09
Evaluation of Performance and Tolerability of Nebulized Hyaluronic Acid Nasal Hypertonic Solution in the Treatment of Chronic Rhinosinusitis. Am J Rhinol Allergy. 2020 May 13;:1945892420923927 Authors: Monzani D, Molinari G, Gherpelli C, Michellini L, Alicandri-Ciufelli M Abstract BACKGROUND: Nasal solutions are part of the recommended therapy of chronic rhinosinusitis (CRS). Formulations containing hyaluronic acid (HA) may represent a promising...
Fri May 15, 2020 13:09
Related ArticlesSpecial Issue about Head and Neck Cancers: HPV Positive Cancers. Int J Mol Sci. 2020 May 11;21(9): Authors: Economopoulou P, Kotsantis I, Psyrri A Abstract The oropharynx has become the leading primary site for Human Papilloma Virus (HPV)-associated head and neck cancer. HPV positive oropharyngeal squamous cell carcinoma (HPV+ OSCC) has emerged as an epidemic not easily recognized by many physicians, resulting in delays in diagnosis...
Fri May 15, 2020 13:09
Related ArticlesThe Alberta Reconstructive Technique: An Occlusion-Driven and Digitally Based Jaw Reconstruction. Laryngoscope. 2019 12;129 Suppl 4:S1-S14 Authors: Seikaly H, Idris S, Chuka R, Jeffery C, Dzioba A, Makki F, Logan H, O'Connell DA, Harris J, Ansari K, Biron V, Cote D, Osswald M, Nayar S, Wolfaardt J Abstract OBJECTIVES/HYPOTHESIS: The free flap reconstructive protocols of the jaws have been refined over the years and presently are based...
Fri May 15, 2020 13:09
Abstract Little is known about facial function assessments of inexperienced observers in facial palsy. In this observational study learning curve was examined of two inexperienced observers assessing facial function of 100 patients using the Sunnybrook Facial Grading System. Interobserver agreement gradually improved over time, stabilizing after approximately 70 assessments. Best agreement on the voluntary movement subscore was observed, followed by synkinesis and resting symmetry subscores....
Sun May 17, 2020 20:21
Abstract Near infrared spectroscopy (NIR) in combination with indocyanine green (ICG) dye can assist surgeons in determining lymph node groups which are likely affected by metastatic cutaneous squamous cell carcinoma of the head, face and neck in real‐time based on an individual patient's lymphatic anatomy. NIR ICG can identify aberrant lymphatic drainage routes which may cause metastatic disease to arise in unexpected areas. NIR mapping can help to inform the magnitude of surgery required...
Sat May 16, 2020 12:58
Abstract Combining serum albumin via adsorption‐exfoliation on hydroxyapatite particles (HAp) with surface‐enhanced Raman scattering (SERS), we developed a novel quantitative analysis of albumin method from blood serum for cancers screening applications. The quantitatively analysis obtained by our HAp method had a good linear relationship from 1 to 10 g/dL, and the lower limit of detection was less than the albumin prognostic factor for disease (3.5 g/dL). Serum albumin was adsorbed and exfoliated...
Sun May 17, 2020 15:40
Abstract Real‐time microscopic imaging of freshly excised tissue enables a rapid bedside‐pathology. A possible application of interest is the detection of oral squamous cell carcinomas (OSCCs). The aim of this study was to analyze the sensitivity and specificity of ex vivo fluorescence confocal microscopy (FCM) for OSCCs and to compare confocal images visually and qualitatively with gold standard histopathology. 280 ex vivo FCM images were prospectively collected and evaluated immediately after...
Sun May 17, 2020 15:04
Hyperspectral imaging and characterization of allergic contact dermatitis in the short‐wave infrared
ABSTRACT Short‐wave infrared hyperspectral imaging (SWIR‐HSI) is applied to diagnose and monitor a case of allergic contact dermatitis due to poison ivy exposure in one subject. This approach directly demonstrates increased tissue fluid content in allergic contact dermatitis lesional skin with a spectral signature that matches the spectral signature of intradermally injected normal saline. The best contrast between the affected and unaffected skin is achieved through a selection of specific wavelengths...
Sat May 16, 2020 20:29
Abstract We show that polarization‐sensitive optical coherence tomography angiography (PS‐OCTA) based on full Jones matrix assessment of speckle decorrelation offers improved contrast and depth of vessel imaging over conventional OCTA. We determine how best to combine the individual Jones matrix elements and compare the resulting image quality to that of a conventional OCT scanner by co‐locating and imaging the same skin locations with closely matched scanning setups. Vessel projection images from...
Sat May 16, 2020 20:09
Abstract A Raman‐based, strain‐independent, semi‐automated method is presented which allows the rapid (< 3 hours) determination of antibiotic susceptibility of bacterial pathogens isolated from clinical samples. Applying a priori knowledge about the mode of action of the respective antibiotic, we identified characteristic Raman marker bands in the spectrum and calculated batch‐wise weighted sum scores from standardized Raman intensity differences between spectra of antibiotic exposed and non‐exposed...
Fri May 15, 2020 11:26
Abstract Skin carcinoma such as melanoma (MM) and cutaneous squamous cell carcinoma (cSCC) are considered as the highest mortality and the most aggressive skin cancers in dermatology. In view that early diagnosis and treatment can greatly improve the survival rate and life quality of the patients, developing noninvasive and effective evaluation methods is of great significance for the detection and identification of early stage cutaneous cancers. In this letter, we proposed a hybrid photoacoustic...
Thu May 14, 2020 22:51
Abstract The technical progress in fast Quantum Cascade Laser (QCL) microscopy offers a platform where chemical imaging becomes feasible for clinical diagnostics. QCL systems allow the integration of previously developed FT‐IR based pathology recognition models in a faster workflow. The translation of such models requires a systematic approach, focusing only on the spectral frequencies that carry crucial information for discrimination of pathologic features. In this study, we optimize an FT‐IR based...
Thu May 14, 2020 15:56
Classification of tissues is an important problem in biomedicine. An efficient tissue classification protocol allows, for instance, the guided‐recognition of structures through treated images, or, discriminating between healthy and unhealthy regions (e.g. early detection of cancer). In this framework, we study the potential of some polarimetric metrics, the so‐called depolarization spaces, for the classification of biological tissues. The analysis is performed using 120 biological ex‐vivo samples...
Thu May 14, 2020 15:55
Abstract Intraoperative bleeding during laser treatment of benign prostate hyperplasia (BPH) often impedes cystoscopic vision, necessitating the use of conventional hemostatic devices. This study proposes an optical technique to improve the efficacy of photothermal hemostasis of bleeders during laser prostatectomy by temporally modulating a 532 nm laser beam. A perfused porcine kidney model is established to quantitatively investigate various optical pulse patterns and irradiation modes. Thermal...
Thu May 14, 2020 11:32
Profiles of Perceived Social Functioning in Adolescent and Young Adult Survivors of Childhood Cancer
Abstract Objectives Social interaction and peer relationships are critical for development, especially for adolescents and young adults (AYA). Cancer treatment may disrupt social functioning and impact quality of life. Prior research into AYA social functioning has primarily been qualitative in nature or assessed via broad measures of functioning. Given the multi‐dimensional nature of social functioning, and its importance for AYA, a person‐centered approach to analyses is needed. Methods...
Sun May 17, 2020 21:19
Abstract Objective In some breast and gynecological cancer centers in Germany, patients participate in multidisciplinary tumor conferences (MTCs) during the discussion of their own case. The aim of this study was to explore providers’ perceptions concerning patients’ emotional experiences during participation in an MTC by comparing the perspectives of providers with and without experience with patient participation. Methods In this study, semi‐structured interviews with n=30 providers in...
Sun May 17, 2020 21:19
Abstract Objective Previous research indicate that the FACIT‐Sp instrument is susceptible to bias when measuring spiritual well‐being in older patients. Our first focus was to evaluate the 2‐factor vs the 3‐factor model of the FACIT‐Sp and our second focus was to explore how these models behave for different age groups. Methods We used a large national cohort of Danish cancer patients (N = 3439) which included a significant number of patients aged at least 70 years (N = 1033). Item‐test...
Sun May 17, 2020 21:18
Abstract Objective Although breast reconstruction has become an important treatment modality following mastectomy, few studies assessed predictors of postoperative sexual outcomes after breast reconstruction. Therefore, we aimed to study three sexual outcomes following implant‐based breast reconstruction (IBBR), and associate multiple biopsychosocial factors with these outcomes. Methods Data collection was part of a multicenter prospective study on IBBR. A predictive model was tested including...
Sun May 17, 2020 21:18
Abstract Objective Sarcoma is a rare cancer that imposes a significant burden on the lives of patients. Many survivors have long‐term disability as a result of treatment and the disease. Patients often experience functional issues, poorer mental health, reduced quality of life, and interpersonal issues. There is a need to explore the unmet needs of sarcoma patients as it is unclear how these issues are being addressed. The aim of this study was to explore the unmet needs of patients who have...
Sun May 17, 2020 21:18
Sun May 17, 2020 21:18
Abstract Objective The goal of this study was to describe the quality of naturalistic communication between patients with advanced cancer and their spouse caregivers using observational methods. We also assessed the association between patient and caregiver communication behaviors and psychological and physical health using the Actor‐Partner Interdependence Model. Methods Data on 81 dyads were gathered as part of a prospective observational study. Patients with advanced cancer and their...
Sun May 17, 2020 21:17
Sun May 17, 2020 21:16
Summary Lung cancer is a common type of cancer that represents a health problem worldwide; lung adenocarcinoma (LUAD) is a major subtype of lung cancer. Although several treatments for LUAD have been developed, the mortality rate remains high because of uncontrollable progression. Further biological and clinicopathological studies are therefore needed. Here, we investigated the role of family with sequence similarity 111 member B (FAM111B), which is highly expressed in papillary‐predominant lung...
Sun May 17, 2020 16:20
Abstract This study aims to identify post‐operative recurrence patterns of pancreatic cancer with different molecular profiles, which provides evidence for personalized target volumes of adjuvant radiotherapy. Patients with pathologically confirmed resectable pancreatic ductal adenocarcinoma were included. Recurrences were treated with SBRT. Immunohistochemical staining of Ki‐67, P53 and PD‐L1 was performed. Both of the intensities of Ki‐67 and P53 were classified as ≤10%, 11%‐49% and ≥50%. Eighty‐nine...
Sun May 17, 2020 16:19
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