Neurodegenerative disorders (NDs) are a group of diseases that cause neural cell damage, leading to motility and/or cognitive dysfunctions. One of the causative agents is misfolded protein aggregates, which are considered as undruggable in terms of conventional tools, such as inhibitors and agonists/antagonists. Indeed, there is currently no FDA‐approved drug for the causal treatment of NDs. However, emerging technologies for chemical protein degradation are opening up the possibility of selective...
Thu May 14, 2020 19:18
Polymer‐drug conjugates are promising as strategies for drug delivery, because of their high drug loading capacity and low premature release profile. However, the preparation of these conjugates is often tedious. In this paper, we report an efficient method for polymer‐drug conjugates using an ultrafast and reversible click reaction in a post‐polymerization functionalization strategy. The reaction is based on the rapid condensation of aryl boronic acid functionalities with salicylhydroxamates. The...
Thu May 14, 2020 16:53
Self‐assembled plasmonic logic gates that read DNA molecule as inputs and return plasmonic chiroptical signals as outputs are reported. Such logic gates are achieved on a DNA‐based platform that logically regulate the conformation of a chiral plasmonic nanostructure, upon specific input DNA strands and internal computing units. With systematical designs, a complete set of Boolean logical gates are realized. Intriguingly, the logic gates could be endowed with adaptiveness, so they can autonomously...
Thu May 14, 2020 13:22
Oxoborane carbamate and carboxylate analogues result from the in situ trapping of [BO 2 ] ‐ produced by elimination of 2,3‐dimethyl‐2‐butene from a pinacolatoboryl anion.
Wed May 13, 2020 22:00
Hepatocellular carcinoma (HCC) has a poor prognosis in the setting of chronic inflammation and fibrosis, both of which promote nuclear DNA oxidative damage. 8‐hydroxy‐deoxyguanosine (8‐OHdG) DNA glycosylase (OGG1) enhances the repair of 8‐OHdG, which is the primary oxidative stress‐induced mutation that leads to malignant alterations. This study aims to clarify the relationships between oxidative stress‐induced factors and HCC progression. The clinicopathological factors were compared with immunohistochemistry...
Sun May 17, 2020 20:21
A 70‐year‐old Japanese man with diabetes mellitus was referred to our hospital for treatment of renal dysfunction. Renal biopsy revealed that the tubular basement membrane (TBM) showed extreme thickening histologically, and selective polyclonal immunoglobulin G deposition on the thickened TBM, whereas no immunoglobulin deposition was found in the glomeruli in an immunofluorescence study. In electron microscopy, a powdery type of electron dense material, which was similar to that seen in Randall‐type...
Sun May 17, 2020 20:15
Ulcerative colitis (UC) is characterized by chronic inflammation in the colonic mucosa and submucosa with repeating relapse and remission, but the pathogenesis is unknown. Patients with long‐standing UC are at high risk of neoplasm development. The aim of the present study was to identify molecules whose expression is associated with UC and UC‐associated colorectal cancer (UCCA). Biopsy specimens from UC and normal colonic mucosae were analyzed using a proteomics approach, in which carbonic anhydrase...
Thu May 14, 2020 19:04
Abstract Angiotensin‐converting enzyme‐2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for the current devastating worldwide pandemic of coronavirus disease 2019 (COVID‐19). ACE2 is abundantly expressed in a variety of cells residing in many different human organs. In human physiology, ACE2 is a pivotal counter‐regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the...
Sun May 17, 2020 19:14
Abstract The classification of the distinct group of mesenchymal neoplasms, first described as ‘Xp11 translocation perivascular epithelioid cell tumor (PEComa)' and for which recently the term ‘melanotic Xp11 neoplasm' or ‘Xp11 neoplasm with melanocytic differentiation' has been proposed, remains challenging and controversial. We collected 27 melanotic Xp11 neoplasms, the largest series to date, for a comprehensive evaluation. Fourteen of the cases, along with 8 alveolar soft part sarcomas (ASPS),...
Sun May 17, 2020 19:12
Abstract Isocitrate dehydrogenase (IDH) wild‐type diffuse lower‐grade glioma (LGG) is usually associated with poor outcome, but there have been disputes over its clinical outcome and classification. We presented here a robust gene expression‐based molecular classification of IDH wild‐type diffuse LGG into two subtypes with distinct biological and clinical features. A discovery cohort of 49 IDH wild‐type diffuse LGGs from Chinese Glioma Genome Atlas (CGGA) was subjected to clustering and function...
Sun May 17, 2020 19:10
Abstract The lymphatic system plays a crucial role in the maintenance of tissue fluid homeostasis and the immunological response to inflammation. The effects of lymphatic drainage dysfunction on periodontitis have not been well‐studied. Here we show that lymphatic vessel endothelial receptor 1 (LYVE1)+/podoplanin (PDPN)+ lymphatic vessels (LVs) are increased in the periodontal tissues, with accumulation close to the alveolar bone surface, in two murine periodontitis models: rheumatoid arthritis...
Sun May 17, 2020 19:03
A discussion of standards, as well as the rationale, purpose, and current activities of the Audiology Practice Standards Organization, written in an engaging Q & A format.
Mon May 18, 2020 07:00
Authors: Michel Boussinesq, Peter Enyong, Patrick Chounna-Ndongmo, Abdel-Jelil Njouendou, Sébastien David Pion, Anthony Rech, Christophe Roberge, Georges Gaudriault and Samuel Wanji.<br />Parasite Vol. 27 , page 36<br />Published online: 18/05/2020<br /> Keywords: Onchocerciasis ; Onchocerca ochengi ; Ivermectin ; Long-acting formulation ; Microfilaricidal effect ; Macrofilaricidal effect.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/4SuvnvQSLrA" height="1"...
Mon May 18, 2020 03:00
Authors: Vivek Bhakta Mathema, Supatchara Nakeesathit, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong.<br />Parasite Vol. 27 , page 34<br />Published online: 15/05/2020<br /> Keywords: Tandem repeats ; Gene ontology ; Microsatellite markers ; Malaria.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/VeXOjyUYmC0" height="1" width="1" alt=""/>
Fri May 15, 2020 03:00
Authors: Zi-Hua Zhou, You-Zhi Li, Lin Liu, Xue-Juan Ding and Kai Yuan.<br />Parasite Vol. 27 , page 33<br />Published online: 15/05/2020<br /> Keywords: Monogenea ; Microcotylidae ; Paracaesicola nanshaensis n. gen. n. sp. ; Paracaesio sordida ; The South China Sea.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/YTDciaU814k" height="1" width="1" alt=""/>
Fri May 15, 2020 03:00
Authors: Junqiang Li, Yueyue Yuan, Yuxi Jiang, Wen Wang, Liqin Chao, Ruiqin Sun, Jun Li, Md Robiul Karim and Meng Qi.<br />Parasite Vol. 27 , page 35<br />Published online: 15/05/2020<br /> Keywords: Blastocystis sp. ; Identification ; Subtype ; Laboratory rats.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/Mveljejmkz4" height="1" width="1" alt=""/>
Fri May 15, 2020 03:00
Abstract Rationale In rodents, acute haloperidol treatment induces psychomotor impairments known as catalepsy, which models akinesia in humans and is characterized as an animal model of acute Parkinsonism, whereas sub-chronic haloperidol reduces exploratory behavior, which resembles bradykinesia. Haloperidol-induced catalepsy in rats can be ameliorated by playback of 50-kHz ultrasonic vocalizations (USV), an emotionally and motivationally...
Mon May 18, 2020 03:00
Related ArticlesErratum. Cell Physiol Biochem. 2020;54(3):515-516 Authors: PMID: 32415766 [PubMed - as supplied by publisher]
Mon May 18, 2020 05:28
Related ArticlesErratum. Cell Physiol Biochem. 2020;54(3):510-512 Authors: PMID: 32415765 [PubMed - as supplied by publisher]
Mon May 18, 2020 05:28
Related ArticlesErratum. Cell Physiol Biochem. 2020;54(3):508-509 Authors: PMID: 32415764 [PubMed - as supplied by publisher]
Mon May 18, 2020 05:28
Related ArticlesStatus Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model. Cell Physiol Biochem. 2020 May 16;54(3):493-507 Authors: Costa AM, Lucchi C, Simonini C, Rosal Lustosa Í, Biagini G Abstract BACKGROUND/AIMS: Status epilepticus (SE) might be followed by temporal lobe epilepsy (TLE), a common neurologic disorder characterized by spontaneous recurrent seizures (SRSs). However, the relationship between SE and...
Mon May 18, 2020 05:28
Related ArticlesErratum. Cell Physiol Biochem. 2020;54(3):513-514 Authors: PMID: 32415762 [PubMed - as supplied by publisher]
Mon May 18, 2020 05:28
Related ArticlesDistinction between the lymph vessel and the vein on ICG lymphography: Intradermal or subcutaneous ICG injection also enhances the vein. J Plast Reconstr Aesthet Surg. 2020 May 05;: Authors: Sumiya R, Fuse Y, Yamamoto T PMID: 32414705 [PubMed - as supplied by publisher]
Mon May 18, 2020 03:33
Related ArticlesA Novel Way for Upper Eyelid Rejuvenation by Combination of Local Fat-Fascia-Muscle Flap Repositioning for Middle-Aged Asian Women. J Plast Reconstr Aesthet Surg. 2019 Oct 10;: Authors: Mao X, Pei Y, Zhang L, Zhang Y, Jin R, Cheng L, Sun X, Zhang Y Abstract BACKGROUND: Upper eyelid aging is common among middle-aged Asians. Apart from skin aging, there has been an increasing recognition for the role of sunken eyelid playing in upper eyelid...
Mon May 18, 2020 03:33
Related ArticlesOrbicularis Oculi Muscle Flap Rotation for Correction of Sunken Eyelid in Cosmetic Blepharoplasty. J Plast Reconstr Aesthet Surg. 2020 Mar 16;: Authors: Chen B, Woo DM, Liu J, Zhu X, Lin Y, Chen X Abstract BACKGROUND: Attempting traditional cosmetic blepharoplasty in a sunken eyelid may cause complications such as multiple folds, irregular or high placement of fold. Additional surgical procedures, such as orbital fat repositioning or...
Mon May 18, 2020 03:33
Related ArticlesFree vascularized medial femoral condyle corticoperiosteal flap with non-vascularized iliac crest graft for the treatment of recalcitrant clavicle non-union. J Plast Reconstr Aesthet Surg. 2020 May 06;: Authors: Jaloux C, Bettex Q, Levadoux M, Cerlier A, Iniesta A, Legre R, Mayoly A, Gay A Abstract Clavicle non-union is a challenging problem. Open reduction with internal fixation and autologous bone grafting is usually the first line...
Mon May 18, 2020 03:33
Objective The aim of this study was to evaluate the diagnostic ability of support vector machine (SVM) for early breast cancer (BC) using dedicated breast positron emission tomography (dbPET). Methods We evaluated 116 abnormal fluorodeoxyglucose (FDG) uptakes less than 2 cm on dbPET images in 105 women. Fluorodeoxyglucose uptake patterns and quantitative PET parameters were compared between BC and noncancer groups. Diagnostic accuracy of the SVM model including quantitative parameters was...
Fri May 01, 2020 03:00
Airway complications (ACs) after lung transplant remain a challenge and include bronchial dehiscence, bronchial stenosis, tracheobronchomalacia, infections, and bronchial fistulas. The spectrum of complications may coexist along a continuum and can be classified as early (1 month), and anastomotic or nonanastomotic. Bronchiolitis obliterans is the most common form of chronic lung allograft rejection. Airway compromise is seen in rare instances of lung torsion, and imaging may provide helpful diagnostic...
Fri May 01, 2020 03:00
Purpose According to certain cancer treatment protocols, the response to induction chemotherapy of lymph node metastases based on radiographic measurements guides further management. The aim of this study is to verify the observation that cystic metastatic lymph nodes tend not to shrink as rapidly as solid metastatic lymph nodes in response to induction chemotherapy in patients with human papillomavirus–related oropharyngeal squamous cell carcinoma. Methods The lymphadenopathy in a cohort...
Fri May 01, 2020 03:00
Objective To establish the normal parameters of fetal lung development at different gestational ages and to study their correlation with gestational age, thereby providing clinicians with a noninvasive method for assessing fetal lung maturity. Methods Two hundred eight cases with pregnancy of 22 to 39 weeks plus 6 days were divided into 18 groups according to gestational age. Ultrasound Doppler was used to measure the relevant parameters of fetal pulmonary development, including right pulmonary...
Fri May 01, 2020 03:00
Objective To assess impact of single-energy metal artifact reduction (SEMAR) algorithm utilizing retrospective adaptive thresholding in reducing metal artifacts in the abdomen and pelvis. Methods In this prospective institutional review board–approved, Health Insurance Portability and Accountability Act–compliant study, 90 patients with various metals (n = 97) on computed tomography of abdomen and pelvis (Canon Medical, Aquilion ONE and PRIME) scanned 07/2017–09/2018 with SEMAR retrospectively...
Fri May 01, 2020 03:00
Objective The aim of the study was to compare intravoxel incoherent motion diffusion-weighted imaging (DWI) for evaluating lung cancer using single-shot turbo spin-echo (TSE) and single-shot echo-planar imaging (EPI) in a 3T MR system. Methods Both single-shot TSE-DWI and single-shot EPI-DWI were scanned twice respectively for 15 patients with lung cancer. Distortion ratio, signal-to-noise ratio, and contrast-to-noise ratio were compared between the 2 techniques. The Bland-Altman analysis...
Fri May 01, 2020 03:00
To report feasibility, safety, and technical advantages of flat-detector computed tomography perfusion (FD-CTP) during balloon test occlusion (BTO) angiography studies, 10 patients patients scheduled for BTO were evaluated. Cerebral blood volume maps were extracted from FD-CTP images acquired during the test. The FD-CTP perfusion combined with BTO is feasible and safe in intracranial tumor, and aneurysm cases in which vessel sacrifice should be considered.
Fri May 01, 2020 03:00
Objective The aim of this study was to evaluate the usefulness of texture analysis of T2-weighted short inversion time inversion recovery (T2-STIR) for detecting myocardial tissue alterations in hypertrophic cardiomyopathy (HCM). Methods Twenty patients with HCM and 11 controls were examined. Texture analysis was performed for the hypertrophied regions with and without and abnormal hyperintensity (AHI) and for the interventricular septum of the controls on T2-STIR. T2 mapping was performed...
Fri May 01, 2020 03:00
The authors investigated the usefulness of diffusion-tensor imaging (DTI) for evaluating tumor invasion depth, histologic grade, and lymph node metastasis in patients with cervical carcinoma (CC). Fifteen consecutive patients with histologically confirmed CC underwent 1.5-T magnetic resonance imaging and DTI. The CCs were clearly depicted as hypointense areas on all DTI maps. Fractional anisotropy, mean diffusivity, and axial diffusivity showed significantly inverse correlations with CC histologic...
Fri May 01, 2020 03:00
Objective The purpose of this article is to provide a primer for radiologists outlining the modern systemic therapies used in melanoma brain metastases, including tyrosine kinase inhibitors and immune checkpoint inhibitors. The role of radiologic treatment response evaluation will be discussed from the standpoint of both modern systemic therapies and more traditional treatments. Conclusion Understanding the role of systemic treatments in melanoma brain metastases is critical for oncologic...
Fri May 01, 2020 03:00
We present clinical and chest computed tomography (CT) features of 5 cases of pediatric patients with 2019 novel coronavirus. Two patients had fever and dry cough, whereas the rest of 3 patients were asymptomatic. Three patients had unilateral ground glass opacities with or without consolidation in the subpleural region on high-resolution chest CT, 1 patient had bilateral ground glass opacities, and 1 patient was negative for CT. We note that up to 66.7% asymptomatic patients had pulmonary lesions,...
Fri May 01, 2020 03:00
Neuronal and mixed glioneuronal tumors represent a group of neoplasms with varying degrees of neural and glial elements. Their age of presentation varies, but they are most commonly seen in children and young adults. With the exception of anaplastic ganglioglioma and other atypical variants, most lesions are low grade; however, they can have significant morbidity because of seizures, mass effect, or difficult to treat hydrocephalus. Although many tumors show overlapping clinical and imaging features,...
Fri May 01, 2020 03:00
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