Shri Ram Sharma, Masaraf Hussain, Debojit RoyNeurology India 2020 68(2):487-488 The manifestations of CNS syphilis are unfamiliar to a differential of patients with dementia to many physicians today as of the relative rarity of this condition. This is a classical case report of a patient with syphilis and dementia in a 55-year-old female. General paresis of insane is a progressive disease of the brain leading to mental and physical worsening. It is important to consider tertiary syphilis in the...
Fri May 15, 2020 00:00
Pin Wang, Lu L Jiang, Cunfu Wang, Zhengyu Zhu, Chao LaiNeurology India 2020 68(2):364-367 Background: Neurofilament proteins as biomarkers of axonal degeneration have the potential to improve our capacity to predict and monitor neurological outcome in experimental autoimmune encephalitis (EAE), a model of multiple sclerosis (MS). We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy. Aims: To highlight the possible roles of...
Fri May 15, 2020 00:00
Rajendra Singh Chouhan, Ankur Khandelwal, Konish Biswas, Rupali BrahmaNeurology India 2020 68(2):493-494
Fri May 15, 2020 00:00
CS Vidhya Annapoorni, Chandra Sadanandavalli Retnaswami, Pooja Mailankody, Pavan Katragadda, Sivakumar Krishna Pillai, Anush Rangarajan, Hansashree Padmanabha, Hima PendharkarNeurology India 2020 68(2):368-372 Introduction: Neurological diseases can be due to direct diseases of the central nervous system (CNS) or peripheral nervous system (PNS) or be a bystander syndrome of systemic diseases. Treatment options depend on the cause. Toxic, metabolic and nutritional, and immune-mediated consequences...
Fri May 15, 2020 00:00
Imran Rizvi, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Ravi UniyalNeurology India 2020 68(2):497-497
Fri May 15, 2020 00:00
Neeharika L Mathukumalli, Ravivarma Dandu, Meena A Kanikannan, Subhash KaulNeurology India 2020 68(2):373-377 Background: The diagnosis of isolated cortical vein thrombosis (ICVT) involving superficial middle cerebral vein (SMCV) remains challenging even in the present era of modern MRI protocols. Objective: The purpose of this study is to review the clinical and radiological characteristics of SMCV thrombosis in our hospital. Methods: Chart review of cases of SMCV thrombosis admitted...
Fri May 15, 2020 00:00
Amirah M Razali, Ayesha M Zain, Norshamsiah M Din, Hui Jan Tan, Chen Fei NgNeurology India 2020 68(2):500-501
Fri May 15, 2020 00:00
Sapna Erat Sreedharan, Bejoy Thomas, PN Sylaja, Sankara P SarmaNeurology India 2020 68(2):378-382 Introduction: Cerebral amyloid angiopathy (CAA) is a major cause of intracerebral hemorrhage (ICH) and cognitive decline in the elderly. Since it is rarely reported from the developing world, we looked into the clinical profile and neuroimaging associations of CAA. Materials and Methods: Ours was a retrospective case series of subjects diagnosed with probable/possible CAA between January 2006 and...
Fri May 15, 2020 00:00
Kajari Bhattacharya, Biswajit Paul, Sukalyan PurkayasthaNeurology India 2020 68(2):504-506
Fri May 15, 2020 00:00
Wenke Liu, Si Zhang, Xuhui Hui, Chao YouNeurology India 2020 68(2):383-388 Context: A well-established cell line of hemangioblastomas (HBs) is still lacking. Aim: This study aims to explore a stable way to establish primary cell lines of HB stromal cells and investigate the morphological and molecular features of these cells. Patients and Methods: Specimens of HBs from 13 patients were collected for establishment of primary cell lines of stromal cells. The details on cell culture were...
Fri May 15, 2020 00:00
Yanming Ren, Chao YouNeurology India 2020 68(2):509-511
Fri May 15, 2020 00:00
Qi Lin, Langlang Tang, Zhiqin LinNeurology India 2020 68(2):389-393 Objective: This study aimed to explore metabolic features in the peritumoral tissue of different-rank brain astrocytic tumors using multivoxel proton magnetic resonance spectroscopy (1H-MRS) and to estimate its application value in the MRS quantitative ratio of brain astrocytic tumors. Materials and Methods: A total of 82 patients with brain astrocytic tumors, confirmed by postoperative pathological evaluation, were divided...
Fri May 15, 2020 00:00
Rajesh Verma, Soumik Sarkar, Sagarika MahapatroNeurology India 2020 68(2):515-517
Fri May 15, 2020 00:00
Erhan Arif Ozturk, Ibrahim Gundogdu, Burak Tonuk, Ebru Umay, Bilge Gonenli Kocer, Aytul CakciNeurology India 2020 68(2):394-400 Background: Although it is well known that patients with Parkinson's disease (PD) have low bone mineral density (BMD) and serum vitamin D level, there are no studies evaluating their relationship with the stage and clinical features of the PD. Objective: The purpose of this study was to evaluate the relationship between BMD and serum vitamin D level and stage or...
Fri May 15, 2020 00:00
Jaechun Hwang, Mi-Yeon EunNeurology India 2020 68(2):522-523
Fri May 15, 2020 00:00
Manmohan Singh, Kanwaljeet GargNeurology India 2020 68(2):401-402
Fri May 15, 2020 00:00
Su Jiahao, Ba Yueyang, Liang Sitao, Liu HuijiaoNeurology India 2020 68(2):525-527
Fri May 15, 2020 00:00
Katsuya Masui, Daisuke Wajima, Shuta Aketa, Fumihiko NishimuraNeurology India 2020 68(2):403-406 Background: This study was performed to examine the efficacy of endoscopic transsphenoidal surgery (ETS) for Cushing's disease at a single institute and to review past reports. Material and Methods: We studied eight consecutive patients who underwent ETS for Cushing's disease. The radiological evaluation comprised a detailed examination of preoperative magnetic resonance images (MRIs), including...
Fri May 15, 2020 00:00
Abstract Socioecological theory predicts that larger groups are able to gain better access to resources because of their numerical advantage in intergroup contests. Nevertheless, the numerical superiority hypothesis has received mixed support, perhaps due to the collective action problem and sex differences in strategies and payoffs. We tested the numerical superiority and the collective action problem hypotheses using 141 intergroup encounters in a 7-year dataset on 5 groups...
Sat May 16, 2020 03:00
Journal of Neurotrauma, Ahead of Print.
Fri May 15, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri May 15, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri May 15, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri May 15, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri May 15, 2020 10:00
Amylase gene clusters have been implicated in adaptive copy number changes in response to the amount of starch in the diet of humans and mammals. However, this interpretation has been questioned for humans and...
Fri May 15, 2020 03:00
Introduction: Overexpression of tight junction protein claudin-4 has been detected in primary and metastatic pancreatic cancer tissue, and is associated with better prognosis in patients. Non-invasive measurement of claudin-4 expression by imaging methods could provide a means for accelerating detection and stratifying patients into risk groups. Clostridium perfringens enterotoxin (CPE) is a natural ligand for claudin-4 and holds potential as a targeting vector for molecular imaging of claudin-4...
Fri May 15, 2020 15:25
The metaiodobenzylguanidine (MIBG) scan is one of the most sensitive noninvasive lesion detection modalities for neuroblastoma. Unlike 123I-MIBG, 124I-MIBG allows high-resolution positron emission tomography (PET). We evaluated 124I-MIBG PET/CT for its diagnostic performance directly compared to paired 123I-MIBG scans. Methods: Prior to 131I-MIBG therapy, standard 123I-MIBG scans (5.2 MBq/kg) that include whole-body (anterior-posterior) planar scans and focused field of view (FOV) single photon...
Fri May 15, 2020 15:25
Objective: Asymmetries of amyloid-β (Aβ) burden, are well-known in Alzheimer’s disease (AD), but did not receive attention in Aβ mouse models of AD. Therefore, we investigated Aβ-asymmetries in Aβ mouse models examined by Aβ- small animal positron-emission-tomography (PET) and tested if such asymmetries have an association with microglial activation. Methods: 523 cross-sectional Aβ-PET scans of five different Aβ mouse models (APP/PS1, PS2APP, APP-SL70, AppNL-G-F and APPswe) were analyzed together...
Fri May 15, 2020 15:25
Peptide receptor radionuclide therapy using radiolabeled octreotate is an effective treatment for somatostatin receptor 2 expressing neuroendocrine tumors. The diagnostic and therapeutic potential of copper-64 and copper-67, respectively, offers the possibility of using a single somatostatin receptor targeted peptide conjugate as a theranostic agent. A sarcophagine cage amine ligand, MeCOSar, conjugated to (Tyr3)-octreotate called, 64Cu-CuSarTATE, was demonstrated as an imaging agent and potential...
Fri May 15, 2020 15:25
Fri May 15, 2020 15:25
Fri May 15, 2020 15:25
Abstract Introduction The most common surgical access techniques employed in patients with orbital floor fractures are associated with a risk of complications, such as implant infection, migration, epiphora, lower eyelid retraction, ectropion, diplopia worsening, retrobulbar hematoma, emphysema, “white-eyed” syndrome, enophthalmia relapse, hypoglobus, and persistent diplopia due to periorbital atrophy. Consequently, alternative access...
Sat May 16, 2020 03:00
Oncogenesis, Published online: 15 May 2020; doi:10.1038/s41389-020-0231-2COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells
Fri May 15, 2020 03:00
Oncogenesis, Published online: 15 May 2020; doi:10.1038/s41389-020-0237-9PRMT1 promotes neuroblastoma cell survival through ATF5
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Facial Plast Surg 2020; 36: 166-175DOI: 10.1055/s-0040-1709515Periocular skin is highly prone to malignancies, especially basal cell and squamous cell carcinomas. Because of the complex anatomy and eye-protecting functions of the periocular tissues, treatment of these cancers requires special considerations. Mohs micrographic surgery is usually the treatment of choice, whenever possible, in order to enhance margin control while limiting collateral damage to nearby normal structures. Cancer excision,...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 194-199DOI: 10.1055/s-0040-1709130Health-related quality of life (HRQOL) is an important measure of patient experience before, during, and after treatment for skin cancers. Over the past 20 years, a variety of generic as well as disease-specific HRQOL instruments have been developed to assess clinical outcomes. Clinical trials have increasingly focused on using HRQOL instruments as outcome measures. Patients with both cutaneous melanoma and nonmelanotic skin cancers have...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 131-132DOI: 10.1055/s-0040-1709120Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 180-185DOI: 10.1055/s-0040-1709119Radiotherapy is a key component in the multidisciplinary treatment of skin cancers, used in definitive management of selected nonmelanomatous skin cancers and as an adjunct treatment in high-risk cases. Understanding the role of radiotherapy in nonmelanoma skin cancers is increasingly important as their incidence continues to rise. This article provides an overview of risk factors associated with nonmelanomatous skin cancers and the principles...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 133-140DOI: 10.1055/s-0040-1709142Basal cell carcinoma, squamous cell carcinoma, and melanoma represent the three most common skin cancers that occur on the face. The most common surgical treatments for facial skin cancers are Mohs' surgery and standard local excision. The effective utilization of either of these techniques is based on tumor and patient risk stratification incorporating known risk factors for occult invasion and local recurrence, combined with patient...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 158-165DOI: 10.1055/s-0040-1709141The nose is the most common site for nonmelanoma skin cancer. Fortunately, most skin cancer lesions on the nose are discovered early and their timely diagnosis and excision result in superficial defects that can be reconstructed with minimal impact on the aesthetics and function. Reconstruction of full-thickness defects of the nose remains a challenging endeavor for reconstructive surgeons. An organized and systematic approach is necessary...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 141-147DOI: 10.1055/s-0040-1709132High-risk nonmelanoma skin cancers of the head and neck may be identified through a variety of tumor risk factors, including location on the lips or ears, size > 2 cm, recurrence, patient immunocompromised status, poor tumor differentiation, > 6 mm thickness, Clark level V depth of invasion, and presence of perineural spread. Surgical excision is the mainstay of treatment, with Mohs' micrographic surgery typically preferred to standard...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 176-179DOI: 10.1055/s-0040-1708843Reconstruction of facial cutaneous defects from skin cancer surgery is a commonly done procedure in the hands of many facial plastic surgeons. Excellent surgical technique should always be employed to reduce the risk of a poor result. However, complications do occur and can be devastating for both the patient and surgeon. We review a range of postoperative management options, and the evidence for each modality, so that reconstructive surgeons...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 148-157DOI: 10.1055/s-0040-1709179There is considerable variation in the surgical management of patients with large facial defects after excision of skin malignancy. The surrounding facial subunits as well as local, regional, and distant soft-tissue flaps can be considered in more complicated facial defects. We place an emphasis on the versatility of adjacent tissue advancement and transposition flaps in the treatment of these defects. We also focus on the secondary reconstructive...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 186-193DOI: 10.1055/s-0040-1709126Cutaneous squamous cell carcinoma (cSCC) and melanoma encompass the majority of all malignant skin cancers. There has been an increase in their incidence globally in recent decades. In cases of high-risk, unresectable, or metastatic disease; or when patient factors or preferences limit the availability of conventional surgery or radiotherapy; or a systemic therapy is often warranted. Our improved understanding of the molecular and immune...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: 200-210DOI: 10.1055/s-0040-1709118There have been several significant advances in cancer treatment in the last decade that are applicable to the treatment of melanoma and advanced nonmelanoma skin cancers. Among these are the development of immune checkpoint inhibitors targeting the programmed death protein-1 (PD-1)/programmed death legand-1 (PDL-1) axis, as well as targeted inhibitors of the BRAF/MEK signaling cascade in melanoma, and the hedgehog signaling pathway in...
Fri May 15, 2020 02:00
Facial Plast Surg 2020; 36: i-iiDOI: 10.1055/s-0040-1713019Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Fri May 15, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1710514 Objective Endovascular treatment of carotid-cavernous fistulas (CCFs) has been consistently shown to give excellent results and is currently the mainstay of treatment of these complex vascular pathologies. Onyx is currently the most widely used agent, but there has been concern over high rates of cranial nerve (CN) deficits seen in patients with CCF treated with Onyx and paucity of data on long-term outcomes. Methods This...
Fri May 15, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1710327 Objectives While most defects after endoscopic endonasal resections can be closed with local or locoregional options, rare cases require free tissue transfer. In this setting, while minimally invasive techniques have been described, the essential procedural details are lacking. The objective of this report is to describe several key technical modifications to free flap harvest and endoscopic-assisted inset which decrease morbidity and...
Fri May 15, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1710517 Objective The junctional triangle, formed by the distal A1 anterior cerebral artery (ACA) segment, the proximal A2 ACA segment, and the medial surface of gyrus rectus (GR), is a corridor of access to superiorly and posteriorly projecting anterior communicating artery (AComA) aneurysms that is widened by GR retraction or resection. Exposure of the AComA complex through the junctional triangle after GR resection has not been previously...
Tue May 05, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1710518 Objectives Hypofractionated stereotactic radiotherapy (HSRT) in two to five fractions may offer patients with large nonfunctioning pituitary adenomas (NFPAs) with chiasm involvement a safe and effective treatment over a single week. However, little has been reported regarding this novel approach. Design We compared the feasibility, outcomes, and toxicity of single-fraction stereotactic radiosurgery and HSRT. Setting This...
Tue May 05, 2020 02:00
High Altitude Medicine &Biology, Ahead of Print.
Fri May 15, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Fri May 15, 2020 10:00
Journal of Clinical Sleep Medicine, <a href="https://jcsm.aasm.org/toc/jcsm/16/5">Volume 16, Issue 5</a>, Page 837-838, May 2020.
Fri May 15, 2020 10:00
A 19-year-old girl was diagnosed with type 1 diabetes and showing polydipsia and polyuria. She was double autoantibody-positive and had a diabetes-prone tissue type. She was immediately started on insulin. Fenofibrate treatment (160 mg daily) was initiated seven days after diagnosis. The need for insulin quickly declined, and she took her last dose of insulin 19 days after the first dose of fenofibrate, having regained endogenous control of blood glucose concentrations. She has now been insulin independent...
Fri May 15, 2020 12:35
Tinnitus, the perception of sound where there is no external sound stimulus, has long been part of the human experience. Because of our current noisy society, this condition affects 1 in 10 adults.1 However, it did not begin with the Industrial Age. There are references to it in Hindu ayurvedic medicine, where it is considered an imbalance of vata dosha, or the wind element, and in classical China, where it was thought to be caused by an imbalance of yin and yang. Mesopotamian remedies included exorcism...
Fri May 15, 2020 03:00
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