Abstract Soft tissue defects in the buttock area are often related to decubitus ulcers, which are usually small to medium‐large size and can be regularly treated with local flaps. However, when the defects have bigger size, such as those involving the whole gluteal region, the coverage can become more challenging, since this specific area needs both a good resistance to pressure and an acceptable functional result. The most common solution for similar cases is the use of multiple local flaps, or,...
Fri May 15, 2020 16:39
Abstract Colorectal cancer (CRC) represents the third cause of cancer‐related mortalities worldwide. The progression of CRC to the metastatic phase significantly compromises the overall survival rates. Despite the advances in the therapeutic protocols, CRC treatment is still challenging. Cancer immunotherapy joined the ranks of surgery, chemotherapy, radiotherapy and targeted therapy as the fifth pillar in the foundation of cancer therapeutics. Interruption of the immunosuppressive signals within...
Sat May 16, 2020 11:34
Abstract Vulvar and vaginal cancers are relatively rare cancers, together responsible for 1.5% of the global cancer incidence among women in 2018. The majority of vaginal cancers, and a lesser proportion of vulvar cancers are associated with HPV. Various reports have indicated rising incidence rates of vulvar cancer in younger women, possibly due to an increased prevalence of high‐risk HPV types. This report assesses recent international variations in the incidence rates of vulvar and vaginal cancer...
Thu May 14, 2020 20:23
Abstract The potential of physical activity to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in ten British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998 and 2003). Alcohol‐related cancer mortality included oral cavity, throat, larynx, oesophagus, liver, colorectal, stomach and female breast...
Thu May 14, 2020 18:03
Abstract EGFR is an oncogene with a high frequency of activating mutations in non‐small cell lung cancer (NSCLC). EGFR inhibitors have been FDA‐approved for NSCLC and have shown efficacy in patients with certain EGFR mutations. However, only 9‐26% of these patients achieve objective responses. In this study, we developed an EGFR gene signature based on The Cancer Genome Atlas (TCGA) RNA‐seq data of lung adenocarcinoma (LUAD) to direct the preselection of patients for more effective EGFR‐targeted...
Thu May 14, 2020 17:42
Case report; meta-synchronous triple malignancy in primary diagnosed CML patient. Am J Blood Res. 2020;10(2):22-25 Authors: Jamal E, El-Ashwah S, Ebrahim MA, Zaki MM, Saleh L, El-Badrawy A, Azmy E Abstract The diagnosis of different types of cancer in a single patient has been appeared in the field in some case reports involving different categories of cancer types either appeared at the same time (synchronous) or subsequently (meta-synchronous). The...
Sun May 17, 2020 07:33
G protein-coupled receptor 68 increases the number of B lymphocytes. Am J Blood Res. 2020;10(2):15-21 Authors: He X, Feng S, Hawkins C, Lawley L, Fan W, Xu Y, Zha XM, Fang J Abstract G protein-coupled receptor 68 (GPR68) is a proton sensor that is activated upon binding to extracellular protons. We have previously found that GPR68 induces a proapoptotic pathway in bone marrow (BM) cells from the patients with myelodysplastic syndromes (MDS) after treated...
Sun May 17, 2020 07:33
Implementation of structured team-based review enhances knowledge consolidation and academic performance of undergraduate medical students studying neuroscience. Adv Physiol Educ. 2020 Jun 01;44(2):232-238 Authors: Anwar K, Kashir J, Sajid MR, Rasool AJ, Shaikh AA, Ikram MF, Yaqinuddin A, Alshedoukhy A, Ganguly PK Abstract Team-based learning (TBL) provides a systematic approach to teaching and learning and promotes critical thinking and enhances medical...
Sun May 17, 2020 07:27
Manipulating leukocyte populations to mimic immune disease states: a novel active approach to teaching flow cytometry to undergraduate immunology students. Adv Physiol Educ. 2020 Jun 01;44(2):247-253 Authors: Costabile M, Nguyen H, Kenyon A Abstract Flow cytometry detects and measures the physical and chemical characteristics of cells or particles. In medical laboratories, flow cytometers are used to quantify changes in cell populations associated with...
Sun May 17, 2020 07:27
Evolution in statistics: P values, statistical significance, kayaks, and walking trees. Adv Physiol Educ. 2020 Jun 01;44(2):221-224 Authors: Curran-Everett D PMID: 32412384 [PubMed - as supplied by publisher]
Sun May 17, 2020 07:27
A comparison of the effectiveness of dissection and prosection on short-term anatomic knowledge retention in a reciprocal peer-teaching program. Adv Physiol Educ. 2020 Jun 01;44(2):239-246 Authors: Lackey-Cornelison WL, Bauler LD, Smith J Abstract Few discussions regarding instructional methods incite as much passion as the debate over dissection versus prosection. Despite numerous analyses, few studies have isolated the impact of dissection versus prosection...
Sun May 17, 2020 07:27
Physiology Understanding Week in a public middle school in Southern Indiana: exercise and health. Adv Physiol Educ. 2020 Jun 01;44(2):254-261 Authors: Terson de Paleville D, Harman K, Richards E, Jaggers JR, King K Abstract The Physiology Understanding (PhUn) Week is a national outreach event sponsored by the American Physiological Society. Our PhUn team conducted an event for 551 students (12.5 ± 0.9 yr old) in a middle school in Indiana. The aims of...
Sun May 17, 2020 07:27
Using two-dimensional ultrasound imaging to examine venous pressure. Adv Physiol Educ. 2020 Jun 01;44(2):262-267 Authors: Johnson CD, Roe SM, Tansey EA Abstract Ultrasound imaging is being used increasingly to aid in the teaching of human physiology and anatomy. Here we describe how its use can be integrated into the teaching of concepts surrounding venous circulation, specifically 1) venous valves and the muscle pump, 2) the effects of hydrostatic pressure...
Sun May 17, 2020 07:27
Cardiovascular and pulmonary interactions: why Galen's misconceptions proved clinically useful for 1,300 years. Adv Physiol Educ. 2020 Jun 01;44(2):225-231 Authors: Neder JA Abstract The new generations of physicians are, to a large extent, unaware of the complex philosophical and biological concepts that created the bases of modern medicine. Building on the Hellenistic tradition of the four humors and their qualities, Galen (AD 129 to c. 216) provided...
Sun May 17, 2020 07:27
Radiation-induced temporal lobe necrosis (TLN) is one of the late post-radiotherapy complications in nasopharyngeal cancer (NPC) patients. Since NPC is common to have skull base infiltration, irradiation of th...
Fri May 15, 2020 03:00
To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.
Thu May 14, 2020 03:00
Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-en...
Thu May 14, 2020 03:00
Prognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model de...
Thu May 14, 2020 03:00
Unilateral condylar hyperplasia (UCH) causes progressive asymmetry of the mandible. The aetiology of this growth disorder is unknown. A two-centre prospective study was established, and 10 consecutive adult UCH patients scheduled for high condylectomy were included. The resected condylar tissue was divided into two parts, one for regular histopathology and one for DNA extraction. A panel of eight selected overgrowth genes (AKT1, AKT3, MTOR, PIK3CA, PIK3R2, PTEN, TSC1, TSC2) were sequenced using next-generation...
Sat May 16, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου