Background Hereditary leiomyomatosis and renal cancer (HLRCC) is a cancer syndrome associated with a germline mutation in fumarate hydratase (FH). The syndrome is associated with cutaneous and uterine leiomyomas, and some patients develop a lethal form of kidney cancer. This study provides estimates for the FH carrier frequency and kidney cancer penetrance. Methods Data sets containing sequencing data for the FH gene were used: the 1000 Genomes Project (1000GP) and the Exome Aggregation Consortium...
Fri May 15, 2020 19:34
Background Anthracycline‐related cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Glutathione S‐transferases (GSTs) are a class of phase II detoxification enzymes that facilitate the elimination of anthracyclines. As free‐radical scavengers, GSTs could play a role in oxidative damage‐induced cardiomyopathy. Associations between the GSTμ1 (GSTM1) null genotype and iron‐overload–related cardiomyopathy have been reported in patients with thalassemia. Methods The...
Fri May 15, 2020 19:34
Fri May 15, 2020 19:34
BACKGROUND Autologous blood or bone marrow transplantation (aBMT) is considered the standard of care for patients with multiple myeloma (MM). Significantly improved survival necessitates an understanding of the morbidity burden borne by the growing survivor population. METHODS The authors evaluated severe and/or life‐threatening chronic health conditions (CHCs) and subsequent neoplasms (SNs) in patients with MM who were treated with aBMT using the Bone Marrow Transplant Survivor Study. A total...
Fri May 15, 2020 19:28
Background The role and impact of radiation therapy (RT) on the development of herpes zoster (HZ) has not been well studied. The objective of this study was to investigate the association between RT and HZ. Methods A propensity score‐matched, retrospective cohort study was conducted using institutional cancer registry data and medical records from 2011 to 2015. The risk of developing HZ in the RT and non‐RT groups was compared using a Cox proportional hazards model. Associations also were...
Fri May 15, 2020 17:03
Abstract Error‐monitoring processes may be affected by transdiagnostic dimensions of psychopathology symptoms including trait anxiety, worry, and severity of depressive symptoms. We tested the relationship between continuous measures of anxiety and depressive symptomology and neural correlates of error‐monitoring as measured by time‐frequency domain delta and theta oscillatory power and time‐domain error‐related negativity (ERN) amplitude extracted from the electroencephalogram (EEG). Secondary...
Fri May 15, 2020 13:20
Abstract Recent event‐related potential (ERP) studies have suggested that the N140cc component reflects target selection mechanisms in tactile search tasks in which the target is presented simultaneously with homogeneous distractors. To investigate if and how the attentional selection of the tactile target is affected by the presence of a singleton distractor, we presented a four‐item search array (two stimuli to the middle and index fingers of the left and right hand) which included a singleton...
Fri May 15, 2020 12:55
Abstract Self‐talk is a psychological skill that benefits motor performance by controlling and organizing performers’ thoughts. While the behavioral effects of self‐talk are clear, research on the mechanisms underpinning the effects of different modes of self‐talk is sparse. To address this issue, we propose and test a psychophysiological model of the effects of self‐talk on motor performance. Forty golf novices practiced a golf putting task while using either instructional or motivational self‐talk...
Fri May 15, 2020 12:44
Skull development and the role of thyroid hormone (TH) in its mediation were studied in Pleurodeles waltl (Urodela; Salamandridae). TH mediation, its changes within ontogeny, and its interplay with tissue inductive interactions are discussed and compared with those in other salamanders. Intraspecific variations in the sequence of cranial bones appearance revealed in P. waltl are proposed to be correlated with individual variations in the internal TH function. Abstract The cranial ossification sequence...
Fri May 15, 2020 14:59
Using humans as a model, we measured how maximum bite forces changed across the tooth row throughout ontogeny. We found that the highest forces are produced by the posterior dentition, which supports the predictions under the Constrained Lever Model. By comparing live bite force data to predicted values from this model, we validated its utility to predict bite forces throughout growth and further contribute to our understanding of how the growing masticatory system produces increased bite force....
Thu May 14, 2020 15:21
Front cover: Cover image: Volume rendering from micro‐CT images of the skull and ear of the red fox Vulpes vulpes. See E.P. Malkemper et al., ‘Functional anatomy of the middle and inner ears of the red fox, in comparison to domestic dogs and cats’, this issue.
Wed May 13, 2020 19:29
Fri May 15, 2020 20:38
Current Anthropology, Ahead of Print.
Fri May 15, 2020 06:12
A novel coronavirus pneumonia outbreak began in Wuhan, Hubei Province, in December 2019; the outbreak was caused by a novel coronavirus previously never observed in humans. China has imposed the strictest quar...
Fri May 15, 2020 03:00
Abstract Diabetes mellitus (DM) is related to impaired bone healing and an increased risk of bone fractures. While it is recognized that osteogenic differentiation and the function of osteoblasts are suppressed in DM, the influence of DM on osteoclasts is still unclear. Hyperglycemia and inflammatory environment are the hallmark of DM that causes dysregulation of various pro-inflammatory cytokines and alternated gene expression in periodontal ligament cells, osteoblasts, osteocytes,...
Sat May 16, 2020 03:00
Abstract Introduction The periosteum has a bilayered structure that surrounds cortical bone. The outer layer is rich in connective tissue and fibroblasts, while the inner layer in contact with the cortical surface of the bone predominantly consists of osteoblasts and osteoblast progenitors. The identification of cell-specific surface markers of the bilayered structure of the periosteum is important for the purpose of tissue regeneration....
Fri May 15, 2020 03:00
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Pain induced by inflammation and nerve injury arises from abnormal neural activity of primary afferent nociceptors in response to tissue damage, which causes long-term elevation of the sensitivity and responsiveness of spinal cord neurons. Inflammatory pain typically resolves following resolution of inflammation; however, nerve injury—either peripheral or central—may cause persistent neuropathic pain, which frequently manifests...
Fri May 15, 2020 08:57
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectivePostoperative neurocognitive disorder (PND) is a main complication that is commonly seen postoperatively in elderly patients. The underlying mechanism remains unclear, although neuroinflammation has been increasingly observed in PND. Atorvastatin is a pleiotropic agent with proven anti-inflammatory effects. In this study, we investigated the effects of atorvastatin on a PND mouse model after peripheral surgery.Material...
Fri May 15, 2020 07:00
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveThis study investigated micro (mi)RNAs associated with the survival of patients with gallbladder carcinoma (GBC).MethodsmiRNA expression profiling was carried out of 40 cancerous tissues from GBC patients with long-term (n = 20) and short-term (n = 20) survival and eight healthy gallbladder tissues from the Gene Expression Omnibus database. miRNAs dysregulated in GBC patients with long-term or short-term survival were...
Thu May 14, 2020 15:51
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Acinic cell carcinoma is a rare, typically indolent, neoplasm that arises in the salivary glands. Metastatic disease is uncommon, occurring in around 10% of cases. We report the case of a 46-year-old male in whom the first sign of disseminated disease was increased skin pigmentation due to paraneoplastic Cushing’s syndrome. He underwent 3 cycles of chemotherapy with carboplatin and paclitaxel with...
Fri May 15, 2020 15:28
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Hyponatremia is the most common electrolyte abnormality encountered both in the inpatient and outpatient clinical settings in the United States. Rapid correction leads to a deranged cerebral osmotic gradient causing osmotic demyelination syndrome. Coexisting azotemia is considered to be protective against osmotic demyelination syndrome owing to its counteractive effect on osmolarity change that occurs...
Fri May 15, 2020 15:27
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Acute pancreatitis is defined as an acute inflammation of the pancreas and is most commonly caused by gallstones and alcohol followed by elevated triglycerides and medications. Estrogen as a cause of secondary hypertriglyceridemic pancreatitis is a rare but known phenomenon in females on hormonal therapy; however, it is not well described in the transgender female population. In this article, we present...
Thu May 14, 2020 13:27
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Tracheobronchopathia osteochondroplastica (TO) is a rare idiopathic and benign disease that is often underdiagnosed. TO is characterized by multiple submucosal cartilaginous and osseous tracheobronchial nodules that spare the posterior wall. It usually affects the elderly, developing when the person is around 60 years old without gender preference and has a reported incidence of 0.11%. TO can be symptomatic...
Thu May 14, 2020 13:23
Yuwa Oka, Hayato Tabu, Sadayuki MatsumotoNeurology India 2020 68(2):512-514
Fri May 15, 2020 00:00
GC KhilnaniNeurology India 2020 68(2):244-245
Fri May 15, 2020 00:00
Deepti Vibha, Kameshwar PrasadNeurology India 2020 68(2):472-473
Fri May 15, 2020 00:00
Prakamya Gupta, N Muthukumar, V Rajshekhar, Manjari Tripathi, Sanjeev Thomas, Sunil Kumar Gupta, Vivek Lal, Pramod Pal, Mathew Abraham, Sanjay Behari, Vimal Paliwal, Daljit Singh, Sanjay Pandey, Lakshmi Narasimhan, Dwarakanath Srinivas, Samhita Panda, SS Kale, P Sarat ChandraNeurology India 2020 68(2):246-254 Background: The COVID-19 infection outbreak has aroused increasing attention and affected thousands of people nationwide. The long incubation period, high infectious rate, varied manifestation,...
Fri May 15, 2020 00:00
Ivonne Becerra-Laparra, David Cortez-Conradis, Haydee Gpe Garcia-Lazaro, Manuel Martinez-Lopez, Ernesto Roldan-ValadezNeurology India 2020 68(2):427-434 Introduction: For the past two decades, diffusion tensor imaging (DTI)-derived metrics allowed the characterization of Alzheimer's disease (AzD). Previous studies reported only a few parameters (most commonly fractional anisotropy, mean diffusivity, and axial and radial diffusivities measured at selected regions). We aimed to assess the diagnostic...
Fri May 15, 2020 00:00
Gagandeep KangNeurology India 2020 68(2):255-256
Fri May 15, 2020 00:00
Constantinos Papadopoulos, Vasiliki Zouvelou, George K PapadimasNeurology India 2020 68(2):495-496
Fri May 15, 2020 00:00
M Sambasivan, KV Mathai, J ChandyNeurology India 2020 68(2):257-261
Fri May 15, 2020 00:00
Adesh Shrivastava, Anirudh Nair, Suresh NairNeurology India 2020 68(2):262-263
Fri May 15, 2020 00:00
Aniruddha Dayama, Rahul Bhargava, Santosh R Kurmi, Sachin Jain, Vikas DuaNeurology India 2020 68(2):454-457 Introduction: Autologous Stem Cell Transplant (ASCT) provides long periods of progression-free-survival in multiple sclerosis (MS). This is an observational study to demonstrate the safety of ASCT in MS patients at a transplant center in North India using a lymphoablative regimen. Materials and Methods: MS patients > 18 years referred by a neurologist or who came of their own volition...
Fri May 15, 2020 00:00
KS Mani, BD Punekar, KT Jagannatha Rao, D Sreedharan NairNeurology India 2020 68(2):264-267
Fri May 15, 2020 00:00
Sanjeev Pattankar, Omkar Churi, Basant K MisraNeurology India 2020 68(2):483-486 Werner syndrome (WS), also known as adult progeria, is extremely rare, with about 1300 known cases in the world, with over 1000 of these in Japan. It occurs due to loss of function mutations in the WRN gene located on chromosome 8p12. WS is characterized by premature aging and increased risk of neoplasms, with meningiomas being the commonest intracranial tumor. We report the case of a 39-year-old male patient, who...
Fri May 15, 2020 00:00
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