Abstract Introduction Whole body magnetic resonance imaging (WB‐MRI) may be more efficient in staging cancers, but can be harder for patients to tolerate. We examined predictors of patient preference for WB‐MRI vs. CT/ PET‐CT for staging colorectal or lung cancer. Methods Patients recruited prospectively to two multicentre trials comparing diagnostic accuracy of WB‐MRI with standard staging scans were sent two questionnaires: the first, administered at trial registration, captured demographics,...
Thu May 14, 2020 18:26
Efficacy of speech language therapy intervention in unilateral vocal fold paralysis - a systematic review and a meta-analysis of visual-perceptual outcome measures. Logoped Phoniatr Vocol. 2020 May 14;:1-13 Authors: Alegria R, Vaz Freitas S, Manso MC Abstract Objective: Unilateral vocal folds paralysis is a disorder that affects a patient's quality-of-life by disturbing their phonation, breathing, and swallowing activities. This systematic review...
Fri May 15, 2020 14:49
Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency. Lab Invest. 2020 May 13;: Authors: Huang M, Kong B, Zhang M, Rizzolo D, Armstrong LE, Schumacher JD, Chow MD, Lee YH, Joseph LB, Stofan M, Zhang L, Guo GL Abstract Alcoholic fatty liver disease (AFLD) is one of the major causes of liver morbidity and mortality worldwide. We have previously shown that whole-body, but not hepatocyte-specific, deficiency of...
Fri May 15, 2020 14:38
Treatment in hormone-sensitive metastatic prostate cancer: factors to consider when personalizing therapy. Expert Rev Anticancer Ther. 2020 May 14;: Authors: Aragon-Ching JB, Dreicer R Abstract INTRODUCTION: The addition of the androgen-signaling inhibitors (ASI) apalutamide, enzalutamide and abiraterone acetate or docetaxel to standard androgen deprivation therapy (ADT) has been demonstrated to improve overall survival in men with hormone-sensitive...
Fri May 15, 2020 14:30
Personality, Chrono-nutrition and Cardiometabolic Health: A Narrative Review of the Evidence. Adv Nutr. 2020 May 14;: Authors: Al Abdi T, Andreou E, Papageorgiou A, Heraclides A, Philippou E Abstract Growing evidence suggests that personality traits play a role in obesity and cardiometabolic health. In addition, irregularity of food intake has emerged as a potential risk factor for obesity, cardiovascular disease, and metabolic syndrome. Recent studies...
Fri May 15, 2020 14:20
Criterion-Related Validity of Spectroscopy-Based Skin Carotenoid Measurements as a Proxy for Fruit and Vegetable Intake: A Systematic Review. Adv Nutr. 2020 May 14;: Authors: Radtke MD, Pitts SJ, Jahns L, Firnhaber GC, Loofbourrow BM, Zeng A, Scherr RE Abstract Carotenoids are a category of health-promoting phytonutrients that are found in a variety of fruits and vegetables and have been used as a biomarker to approximate dietary fruit and vegetable...
Fri May 15, 2020 14:20
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Gan To Kagaku Ryoho"[jour] These pubmed results were generated on 2020/05/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri May 15, 2020 14:13
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Gan To Kagaku Ryoho"[jour] These pubmed results were generated on 2020/05/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri May 15, 2020 13:10
Correction: Characteristic analysis of TCR β-chain CDR3 repertoire for preand post-liver transplantation. Oncotarget. 2020 May 05;11(18):1679 Authors: Yang G, Ou M, Chen H, Guo C, Chen J, Lin H, Tang D, Xue W, Li W, Sui W, Dai Y Abstract [This corrects the article DOI: 10.18632/oncotarget.26138.].PMID: 32405342 [PubMed - in process]
Fri May 15, 2020 13:52
Clinical implications of chromatin accessibility in human cancers. Oncotarget. 2020 May 05;11(18):1666-1678 Authors: Liu Y Abstract Assay for transposase-accessible chromatin using sequencing (ATAC-seq) has not yet been widely used in cancer research. Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown. In this study, we analyzed ATAC-seq data in...
Fri May 15, 2020 13:52
Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line. Oncotarget. 2020 May 05;11(18):1653-1665 Authors: Kobayashi M, Ishizaki Y, Owaki M, Matsumoto Y, Kakiyama Y, Hoshino S, Tagawa R, Sudo Y, Okita N, Akimoto K, Higami Y Abstract Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in single strand DNA repair. PARP1 inhibitors enhance the effects...
Fri May 15, 2020 13:52
Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study. Oncotarget. 2020 May 05;11(18):1637-1652 Authors: Santos JR, Waitzberg DL, da Silva IDCG, Junior TCT, Barros LRC, Canuto GAB, Faccio AT, Yamaguchi LF, Kato MJ, Tavares MFM, Martinez AC, Logullo ÂF, Torrinhas RSMM, Ravacci G Abstract Altered cell metabolism is a hallmark of cancer and critical for its development. Particularly,...
Fri May 15, 2020 13:52
Expression of Nrf2 and NF-κB transcription factors in breast cancer and breast fibroadenoma: Insights for a new therapeutic approach. Oncotarget. 2020 May 05;11(18):1629-1636 Authors: Simplicio-Revoredo CM, de Oliveira Pereira R, de Almeida Melo M, Lopes-Costa PV, de Tarso Moura-Borges P, Sousa EB, Neto FM, Campelo V, Soares-Lopes IMR, da Conceição Barros-Oliveira M, Tavares CB, Dos Santos AR, de Araújo CGB, Coelho EG, Campos-Verdes LC, do Nascimento-Holanda AO, Viana...
Fri May 15, 2020 13:52
Hyperprogression and impact of tumor growth kinetics after PD1/PDL1 inhibition in head and neck squamous cell carcinoma. Oncotarget. 2020 May 05;11(18):1618-1628 Authors: Karabajakian A, Garrivier T, Crozes C, Gadot N, Blay JY, Bérard F, Céruse P, Zrounba P, Saintigny P, Mastier C, Fayette J Abstract Background: Hyperprogressive disease (HPD) rate in head and neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint inhibitors...
Fri May 15, 2020 13:52
Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. Oncotarget. 2020 May 05;11(18):1603-1617 Authors: Kumar M, Martin A, Nirgude S, Chaudhary B, Mondal S, Sarkar A Abstract BACKGROUND: Quinacrine (QC) is popular for its anti-malarial activity. It has been reported exhibiting anti-cancerous properties by suppressing nuclear factor-κB and activating p53 signaling;...
Fri May 15, 2020 13:52
Expression of angiopoietin-like 4 fibrinogen-like domain (cANGPTL4) increases risk of brain metastases in women with breast cancer. Oncotarget. 2020 May 05;11(18):1590-1602 Authors: Dao T, Gapihan G, Leboeuf C, Hamdan D, Feugeas JP, Boudabous H, Zelek L, Miquel C, Tran T, Monnot C, Germain S, Janin A, Bousquet G Abstract BACKGROUND: Brain metastases challenge daily clinical practice, and the mechanisms by which cancer cells cross the blood-brain...
Fri May 15, 2020 13:52
The anti-tumor activity of pralatrexate (PDX) correlates with the expression of RFC and DHFR mRNA in preclinical models of multiple myeloma. Oncotarget. 2020 May 05;11(18):1576-1589 Authors: Kinahan C, Mangone MA, Scotto L, Visentin M, Marchi E, Cho HJ, O'Connor OA Abstract Multiple myeloma (MM) is the second most common hematologic malignancy. While major advances have been made in the disease, it is still incurable. Although antifolate-based drugs...
Fri May 15, 2020 13:52
[Spectroscopic investigation of the middle ear mucosa]. HNO. 2020 May 13;: Authors: Berg T, Kluge A, Steiner G, Zahnert T, Neudert M Abstract BACKGROUND: The middle ear mucosa (MEM) plays a central role in the middle ear due to its function of providing regular ventilation. To date, assessment of the state of the MEM is only possible subjectively by the surgeon. An objective characterization of the state of the MEM is desirable. OBJECTIVE:...
Fri May 15, 2020 13:44
[Radicality of maxillary sinus surgery and size of the maxillary sinus ostium]. HNO. 2020 May 13;: Authors: Sommer F, Hoffmann T, Lindemann J, Hahn J, Theodoraki MN Abstract Until the 1990s, radical sinus surgery was considered a standard procedure for maxillary sinus diseases, but it is no longer favored due to the high morbidity. Today, functional endoscopic sinus surgery (FESS) is considered the gold standard in sinus surgery. Modifications of...
Fri May 15, 2020 13:44
[Surgical anatomy of the maxillary sinus]. HNO. 2020 May 13;: Authors: Hosemann W, Grimm A Abstract BACKGROUND: Improved understanding of the microanatomy of the paranasal sinuses, including its individual variations, makes a substantial contribution to current progress in endonasal endoscopic microsurgery. Microanatomy of the sinuses is an active field of present scientific investitations. MATERIALS AND METHODS: A comprehensive review...
Fri May 15, 2020 13:44
[Function and physiology of the maxillary sinus]. HNO. 2020 May 13;: Authors: Sieron HL, Sommer F, Hoffmann TK, Grossi AS, Scheithauer MO, Stupp F, Lindemann J Abstract BACKGROUND: The question of the "true" function of the maxillary sinus and the paranasal sinuses (PS) has been a controversial issue in the literature for decades, leading to many discussions and speculations. OBJECTIVE: This review briefly summarizes various theories on...
Fri May 15, 2020 13:44
[The maxillary sinus via a prelacrimal approach as a gateway to the retromaxillary space and orbital floor]. HNO. 2020 May 13;: Authors: Kühnel T Abstract Endonasal surgery has emerged as the standard procedure for the majority of nasal and paranasal sinus pathologies. However, some pathological changes beyond the maxillary sinus seem to be out of the instrumental range and are addressed by open approaches. The prelacrimal approach to the maxillary...
Fri May 15, 2020 13:44
Estrogen Replacement Reduces Hearing Threshold Shifts and Cochlear Hair Cell Loss After Acoustic Overexposure in Ovariectomized Rats. Clin Exp Otorhinolaryngol. 2020 May 15;: Authors: Kim MT, Lee JH, Carpena NT, Lee MY, Chung PS, Jung JY Abstract Objectives: The relationship of estrogen (the primary female sex hormone) with hearing function has been studied in both humans and animals. However, whether estrogen levels affect hearing remains uncertain....
Fri May 15, 2020 13:44
Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis. Clin Exp Otorhinolaryngol. 2020 May 15;: Authors: Lee KI, Bae JS, Kim EH, Kim JH, Lyu L, Chung YJ, Mo JH Abstract Objectives: Limited information is available regarding strain-related differences in mouse models of allergic rhinitis induced by Dermatophagoides farinae (Der f1). In this study, we compared differences between two mouse strains...
Fri May 15, 2020 13:44
Abstract Purpose To evaluate the influence of preparation design and tooth geometry on the accuracy of scans obtained from three different intraoral scanners (IOS) Materials and Methods Full coverage crown and inlay preparations with known axial wall tapers (6ᵒ and 12ᵒ) were performed on typodont teeth using a computer numerical control machine. Reference models were scanned with a highly accurate reference scanner (Ineos X5) and saved in standard tessellation language (STL) format then...
Thu May 14, 2020 22:53
Related ArticlesAmplification of abiotic stress tolerance potential in rice seedlings with a low dose of UV-B seed priming. Funct Plant Biol. 2019 04;46(5):455-466 Authors: Thomas DT, Puthur JT Abstract UV-B radiation is a major abiotic stress factor that adversely affects the growth and productivity of crop plants including rice (Oryza sativa L.). However, on the other hand, lower doses of UV-B radiation applied to seeds can have a priming effect on...
Fri May 15, 2020 13:37
INSPIRE Neuro-Spinal ScaffoldTM : An Implantable Alternative to Stem-Cell Therapy for Endogenous Repair in Spinal Cord Injury. J Korean Neurosurg Soc. 2020 May 15;: Authors: Brown N PMID: 32407612 [PubMed - as supplied by publisher]
Fri May 15, 2020 13:22
Visualizing the invisible: class excursions to ignite children's enthusiasm for microbes. Microb Biotechnol. 2020 May 14;: Authors: McGenity TJ, Gessesse A, Hallsworth JE, Garcia Cela E, Verheecke-Vaessen C, Wang F, Chavarría M, Haggblom MM, Molin S, Danchin A, Smid EJ, Lood C, Cockell CS, Whitby C, Liu SJ, Keller NP, Stein LY, Bordenstein SR, Lal R, Nunes OC, Gram L, Singh BK, Webster NS, Morris C, Sivinski S, Bindschedler S, Junier P, Antunes A, Baxter BK, Scavone P,...
Fri May 15, 2020 13:04
Jackhammer esophagus is a newly described but misunderstood esophageal motility disorder. Here, we present a meta‐analysis of published data on this new disorder presenting a clearer picture of its demographics, presentation, manometric findings, and treatment outcomes. Abstract Background Jackhammer esophagus (JE) is a newly described esophageal motility disorder. However, there are limited data on JE and this entity remains misunderstood. Methods We performed a systematic review...
Thu May 14, 2020 13:49
Background and Objective Until recently, quality‐switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730‐nm wavelength was developed to specifically target melanin and melanocytes. Study Design/Materials and Methods We report on two Asian patients with freckles, lentigines, and...
Thu May 14, 2020 20:19
New Findings What is the central question of this study? What are the effects of a two‐week period of severe food restriction on vascular reactivity of resistant arteries and on cardiac structure and function? What is the main finding and its importance? This study shows for the first time that a two‐week period of severe food restriction in adult male Fischer rats caused endothelial dysfunction in mesenteric arteries and increased susceptibility to ischemia/reperfusion‐induced...
Thu May 14, 2020 20:49
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Lung cancer remains one of the leading causes of cancer deaths around the world. Previous studies have shown that microRNAs have pivotal functions in tumorigenesis including lung cancer. It is reported that microRNA-195-5p acts as a tumor suppressor role in human cancers. However, the function and molecular mechanism of microRNA-195-5p in lung cancer progression is still unclear. In the present study, the results...
Thu May 14, 2020 13:39
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Desloratadine, a potent antagonist for human histamine H1 receptor, has been revealed to exhibit antihistaminic activity and anti-inflammatory activity. However, it is not yet known whether desloratadine has any effect on the biological behaviors of tumor cells. In this study, we aimed to investigate the effects of desloratadine on cell growth and invasion in bladder cancer EJ and SW780 cells in vitro. We observed...
Thu May 14, 2020 13:16
Here is a brief video discussion between me and potential Radiologists just joining the field about AI is it a friend or a foe?Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Fri May 15, 2020 10:51
Purpose:Evaluating drug responses using primary patient-derived cells ex vivo represents a potentially rapid and efficient approach to screening for new treatment approaches. Here, we sought to identify neratinib combinations in HER2 mutant non–small cell lung cancer (NSCLC) patient xenograft-derived organotypic spheroids (XDOTS) using a short-term ex vivo system. Experimental Design:We generated two HER2-mutant NSCLC PDX models [DFCI359 (HER2 exon19 755_757LREdelinsRP) and DFCI315 (HER2 exon20...
Fri May 15, 2020 10:05
Childhood cancer survivors experience substantial treatment-related morbidity and biomarkers of long-term survivor health are needed. Leukocyte telomere length is shortened in childhood cancer survivors and associates with the occurrence of numerous chronic health conditions. Healthy lifestyle factors can attenuate telomere attrition in young-adult survivors, implicating critical windows for intervention. See related article by Song et al., p. 2362
Fri May 15, 2020 10:05
On March 8, 2019, the FDA granted accelerated approval to atezolizumab in combination with paclitaxel protein-bound for the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumors express PD-L1 [PD-L1 stained tumor-infiltrating immune cells (IC) of any intensity covering ≥1% of the tumor area], as determined by an FDA-approved test. Approval was based on data from IMpassion130, which randomized patients to receive atezolizumab...
Fri May 15, 2020 10:05
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