Prognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model de...
Thu May 14, 2020 03:00
Unilateral condylar hyperplasia (UCH) causes progressive asymmetry of the mandible. The aetiology of this growth disorder is unknown. A two-centre prospective study was established, and 10 consecutive adult UCH patients scheduled for high condylectomy were included. The resected condylar tissue was divided into two parts, one for regular histopathology and one for DNA extraction. A panel of eight selected overgrowth genes (AKT1, AKT3, MTOR, PIK3CA, PIK3R2, PTEN, TSC1, TSC2) were sequenced using next-generation...
Sat May 16, 2020 03:00
Q4: Horizontal changes occur following bilateral sagittal split osteotomy (BSSO) in skeletal class III patients. The aim of this study was to assess the ostoperative changes in intergonial (IG) width and compare them between the positional screw and miniplate fixation methods in BSSO. This study evaluated patients who had mandibular prognathism and underwent BSSO for mandibular setback. Internal fixation was performed bilaterally, either with positional screws in the lateral ramus or with a miniplate.
Fri May 15, 2020 03:00
Evolutionary biologists studying populations of hybrid fish have found two genes that contribute to melanoma - only the second time people have identified specific genes associated with dysfunction in hybrid vertebrates.
Thu May 14, 2020 23:42
Size, safety and parenting all have an impact on how quickly a species of bird matures, according to new research that could help scientists to understand and predict how animals will respond to climate breakdown and the destruction of habitats.
Thu May 14, 2020 16:25
Catmint -- or catnip -- is well-known for its intoxicating effect on cats. The odor responsible for the cats' strange behavior is nepetalactone, a volatile iridoid. Researchers have now found that the ability to produce iridoids had already been lost in ancestors of catmint. Hence, nepetalactone biosynthesis is the result of 'repeated evolution.' However, nepetalactone differs considerably from other iridoids with regards to its chemical structure and properties, and most likely its ecological functions.
Wed May 13, 2020 21:37
Pangolins lack two genes that function to sound the alarm when a virus enters the body, triggering an immune response in most other mammals. The findings are significant because, while the exotic animals can be carriers of coronavirus, they appear able to tolerate it through some other unknown mechanism. Understanding how pangolins are able to survive coronavirus may point to possible treatment options for humans.
Fri May 08, 2020 15:35
Abstract Purpose Little is known regarding the influence of in-laboratory polysomnography (PSG) equipment on sleep position, especially on the prevalence of supine positioning, which in many cases may lead to a more severe sleep apnea diagnosis. The aim of this study was to assess the percentage of supine sleep during an in-laboratory PSG compared to that seen during a home sleep apnea test (HSAT). ...
Sat May 16, 2020 03:00
Abstract Background Another transoral tongue base surgical procedure for obstructive sleep apnea (OSA) is described. The procedure was named as the “Robo-Cob” technique because it is similar to transoral robotic surgery (TORS) but using a coblation technology to manage tongue base hypertrophy in patients with OSA especially in countries where TORS is not an available option for such benign conditions. ...
Sat May 16, 2020 03:00
Abstract Purpose Depression symptoms are closely related to inadequate sleep and are experienced by medical students at an increased rate. Bedtime procrastination is considered a new, important predictor of sleep deficiency. However, whether there is a correlation between bedtime procrastination and depression symptoms remains unclear. This study aimed to examine the impact of bedtime procrastination on depression symptoms among medical...
Fri May 15, 2020 03:00
The aminoquinolines chloroquine and hydroxychloroquine are widely used in the treatment of malaria and rheumatic diseases, and they have been suggested as effective treatments for coronavirus disease 2019 (Covid-19) on the grounds of both antiinflammatory and antiviral effects. In the United…
Thu May 07, 2020 03:00
As the United States navigates one of the most serious pandemics in history, much of the country has been shut down to prevent devastating local outbreaks that threaten lives and can overwhelm hospitals. A breakdown in the federal disaster response delayed state and local responses, allowing…
Fri May 15, 2020 03:00
This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations. A 50-year-old, previously…
Fri May 15, 2020 03:00
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. Massachusetts quickly followed New York in becoming an epicenter of…
Fri May 15, 2020 03:00
The rapid spread of SARS-CoV-2, a novel coronavirus that emerged in late 2019, and the resulting Covid-19 disease has been labeled a Public Health Emergency of International Concern by the World Health Organization. What physicians need to know about transmission, diagnosis, and treatment is the…
Thu May 14, 2020 03:00
To the Editor: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects cells in the respiratory tract, but its direct affinity for organs other than the lungs remains poorly defined. Here, we present data from an autopsy series of 27 patients (see the clinical data in…
Wed May 13, 2020 03:00
To the Editor: Reports of human-to-feline transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of limited airborne transmission among cats prompted us to evaluate nasal shedding of SARS-CoV-2 from inoculated cats and the subsequent transmission of the virus by direct…
Wed May 13, 2020 03:00
Acute asthma management during SARS-CoV2-pandemic 2020. World Allergy Organ J. 2020 May 14;:100125 Authors: Levin M, Morais-Almeida M, Ansotegui IJ, Bernstein J, Chang YS, Chikhladze M, Ebisawa M, Fiocchi A, Heffler E, Martin B, Papadopoulos NG, Peden D, Wong GWK Abstract Background: The current COVID-19 pandemic has changed many medical practices in order to provide additional protection to both our patients and our healthcare providers. In many...
Sat May 16, 2020 20:58
Abstract A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network is proposed. Firstly, a Siamese network with two identical convolutional neural network (CNN) sub-networks and a logistic regression for leukocyte five classification is designed, which can learn not only distinguishing features but also a similarity metric. Then for each category of the leukocytes, a typical sample is selected by the hematologist. To train the Siamese...
Sat May 16, 2020 03:00
Abstract The purpose of this study is to assess and model age-related changes in the mechanical properties of human fascia. The samples were divided into three age groups: group A—up to 60 years (mean age 52.5 ± 6 years), group B—61–80 years (mean age 70.4 ± 5.2 years), and group C—81–90 years (mean age 83.2 ± 2 years). A uniaxial tensile test was applied to fascia specimens cut perpendicular and parallel to fibers. The secant modulus at 5% strain, the maximum stress, and the stretch...
Sat May 16, 2020 03:00
Publication date: Available online 16 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Wayne Pearce, Jeremy Barr, Kasra Ziai, Neerav Goyal
Sat May 16, 2020 20:44
Publication date: Available online 15 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Dana Goldenberg, Sonia Vaida
Sat May 16, 2020 20:44
Publication date: Available online 14 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Keith B. Greenland
Fri May 15, 2020 13:13
Abstract Purpose APOBEC3A and APOBEC3B cytidine deaminases have been implicated in the pathogenesis of multiple cancers, including breast cancer (BC). A germline deletion linking APOBEC3A and APOBEC3B loci (A3A/B) has been associated with higher APOBEC-mediated mutational burden, but its association with BC risk have been controversial. Therefore, this study investigated the association between A3A/B and BC susceptibility and...
Sat May 16, 2020 20:22
Abstract Purpose To evaluate pregnancy rates, time to pregnancy (TTP) and obstetric outcomes in female childhood cancer survivors (CCSs) and to identify specific diagnosis- and treatment-related factors associated with these outcomes. Methods The study is part of the DCOG LATER-VEVO study, a nationwide multicenter cohort study evaluating...
Sat May 16, 2020 20:22
Abstract Purpose Physical activity (PA) is important for cancer patients during and after therapy with respect to reducing side effects and improving quality of life. The aim of the study was to examine how physically active German cancer patients are and to identify predictors for PA. In addition, patients were asked about their attitude towards PA. Methods...
Sat May 16, 2020 20:22
Abstract Purpose Burkitt lymphoma (BL) is one of the most frequent subtypes of non-Hodgkin lymphoma (NHL) in children. Currently, short, intensive chemotherapy is used internationally and has greatly improved survival in children with BL. However, 5–10% of patients suffer recurrence after intensive chemotherapy, and the prognosis of these patients remains poor. The overall survival rate is only approximately 10%. Innovative therapies...
Sat May 16, 2020 20:22
Abstract Background and study aims Though intrapapillary capillary loops (IPCL) can be used to diagnose the staging of superficial esophageal squamous cell carcinoma (SESCC), the accuracy still remains controversial. Moreover, which IPCL classification is more suitable for clinical application is unclear. The aim was to evaluate the diagnostic performance of different IPCL classifications and to explore a new classification. ...
Sat May 16, 2020 20:22
Abstract Purpose Imaging manifestations of hepatic lymphoma, both primary (PHL) and secondary (SHL), are extremely variable and non-specific, but some features are useful diagnostic clues in an appropriate clinical setting. Through a PubMed search, we found several published reviews focused on PHL and SHL diagnosis. However, to the best of our knowledge, few of them encompass a comprehensive analysis of all the diagnostic tools...
Sat May 16, 2020 20:22
Abstract Background Accounting for tumor heterogeneity, cancer stem cells (CSC) are involved in tumor metastasis, relapse, and drug resistance. Genes regulating CSC characteristics in lung adenocarcinoma (LUAD) were explored and validated in this study. Methods The mRNA stemness index (mRNAsi) of more than 500 LUAD cases from The Cancer...
Sat May 16, 2020 20:22
Abstract Introduction Major histocompatibility complex (MHC) plays an important role in colorectal cancer (CRC) immunity. However, the function of MHC class I chain-related B (MICB) molecule is not very clear. In this study, we explored the prognostic effect of MICB in colorectal cancer. Material and methods From 2008-05 to 2012-11, consecutive...
Sat May 16, 2020 20:22
Abstract Purpose Classical type of lobular neoplasia (LN) spans a spectrum of disease, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS), classical lobular neoplasia (LN), and the three-tiered classification of lobular intraepithelial neoplasia (LIN-1, -2, -3). This study addressed inter-observer variability of classical lobular neoplasias (LN) (B3 lesions) in preoperative breast biopsies among...
Sat May 16, 2020 20:22
Abstract Objective Public discussion and health-care systems worldwide have been focusing on the COVID-19 pandemic. Does it have an impact on cancer care today? Materials and methods The PRIO (“Prevention and Integrative Oncology”) Working Group (German Cancer Society) has initiated an online survey for physicians, medical staff and patients on April...
Fri May 15, 2020 03:00
Well-Differentiated/Dedifferentiated Liposarcoma Arising in the Upper Aerodigestive Tract: 8 Cases Mimicking Non-adipocytic Lesions. Head Neck Pathol. 2020 May 14;: Authors: Fritchie K, Ghosh T, Graham RP, Roden AC, Schembri-Wismayer D, Folpe A, Rivera M Abstract Well-differentiated (WDL) and dedifferentiated liposarcomas (DL) of the pharynx, larynx and oral cavity are rare, often mimicking benign lipomatous neoplasms or non-lipogenic mesenchymal tumors....
Sat May 16, 2020 20:15
Controlling porous titanium/soft tissue interactions with an innovative surface chemical treatment: Responses of macrophages and fibroblasts. Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110845 Authors: Barthes J, Cazzola M, Muller C, Dollinger C, Debry C, Ferraris S, Spriano S, Vrana NE Abstract In order to create a stable interface with the host tissue, porous implants are widely used to ensure the in-growth of the cells and the colonization of the...
Sat May 16, 2020 20:03
Publication date: Available online 15 May 2020Source: American Journal of Infection ControlAuthor(s): Daniel F. Li, Jennifer L. Cadnum, Sarah N. Redmond, Lucas D. Jones, Basya Pearlmutter, Muhammed F. Haq, Curtis J. Donskey
Sat May 16, 2020 19:24
Sat May 16, 2020 19:09
Abstract Immune checkpoint inhibitor (ICI)-related pneumonitis is a relatively rare but clinically serious and potentially life-threatening adverse event. The majority of cases can be managed by drug discontinuation, with the administration of corticosteroids added in severe cases. However, worsening of pneumonitis can develop in a subset of patients despite treatment with high doses of corticosteroids. We herein report a case of steroid-refractory ICI-related pneumonitis in a...
Fri May 15, 2020 03:00
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