Related ArticlesSpontaneous regression of mismatch repair deficient colorectal cancers: a case series. Dig Endosc. 2020 May 16;: Authors: Utsumi T, Miyamoto S, Shimizu T, Yokogawa K, Nakanishi Y, Nikaido M, Hirata A, Nishida M, Aoyama I, Okuno T, Yoshizawa A, Kaneda A, Sakai Y, Kawanami C, Seno H Abstract Spontaneous regression (SR) has been reported in various malignant tumors. However, SR in colorectal cancer (CRC) is particularly rare and the mechanism...
Sun May 17, 2020 23:57
Related ArticlesRare cancers in Canada, 2006-2016: A population-based surveillance report and comparison of different methods for classifying rare cancers. Cancer Epidemiol. 2020 May 13;67:101721 Authors: Walker EV, Maplethorpe E, Davis FG Abstract BACKGROUND: The cumulative burden from rare cancers has not been adequately explored in Canada. This analysis aims to characterize the occurrence of rare cancers among Canadians and estimate the probability...
Sun May 17, 2020 23:57
Related ArticlesIncidental detection of microfilaria in cyst fluid of Mucinous cystadenocarcinoma of ovary: A rare case report. Int J Surg Case Rep. 2020 May 11;70:56-59 Authors: Vasantham V, Yadav SK, Sarin N, Singh S, Pruthi SK Abstract INTRODUCTION: Filariasis is a major health problem in certain parts of India. Microfilaria detection on exfoliative and fluid cytology is extremely rare and it is even very rare to find microfilaria coexistent with...
Sun May 17, 2020 23:57
Related ArticlesPontine neoplasm or myelinolysis despite normal sodium levels. World Neurosurg. 2020 May 13;: Authors: Andereggen L, Remonda L Abstract An elderly woman was transferred for biopsy of a pontine lesion. Her condition, including gait disturbances, truncal ataxia, and dysarthria - presumed to be due to a history of severe alcohol abuse - deteriorated over the course of treatment for ambulatory-acquired pneumonia. No electrolyte abnormalities...
Sun May 17, 2020 23:57
Related ArticlesDermoscopic features and differential diagnosis of sebaceous carcinoma. J Dermatol. 2020 May 16;: Authors: Cheng CY, Su HJ, Kuo TT Abstract Sebaceous carcinoma is a rare malignant skin neoplasm arising from sebaceous glands. Its clinical diagnosis is difficult and reports of dermoscopic findings have been limited. This study aims to analyze its dermoscopic features and differential diagnosis in dermoscopic examination. The study included...
Sun May 17, 2020 23:57
Related ArticlesMeningioma in a patient with Werner syndrome. Neurol India. 2020 Mar-Apr;68(2):483-486 Authors: Pattankar S, Churi O, Misra BK Abstract Werner syndrome (WS), also known as adult progeria, is extremely rare, with about 1300 known cases in the world, with over 1000 of these in Japan. It occurs due to loss of function mutations in the WRN gene located on chromosome 8p12. WS is characterized by premature aging and increased risk of neoplasms,...
Sun May 17, 2020 23:57
Related ArticlesAvelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial. J Immunother Cancer. 2020 May;8(1): Authors: D'Angelo SP, Bhatia S, Brohl AS, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Georges S, Shah P, Ellers-Lenz B, Bajars M, Güzel G, Nghiem PT Abstract BACKGROUND: Merkel cell...
Sun May 17, 2020 23:57
Related ArticlesMerkel Cell Carcinoma Treatment in Finland in 1986-2016-A Real-World Data Study. Cancers (Basel). 2020 May 13;12(5): Authors: Sahi H, Their J, Gissler M, Koljonen V Abstract Merkel cell carcinoma (MCC) is a rare cutaneous carcinoma that has gained enormous interest since the discovery of Merkel cell polyoma virus, which is a causative oncogenic agent in the majority of MCC tumours. Increased research has focused on effective treatment...
Sun May 17, 2020 23:57
Related ArticlesNeuroendocrine Cancer of the Breast: A Rare Entity. J Clin Med. 2020 May 13;9(5): Authors: Irelli A, Sirufo MM, Morelli L, D'Ugo C, Ginaldi L, De Martinis M Abstract Neuroendocrine breast cancer (NEBC) is a rare histotype of breast carcinoma that presents, in most cases, positive hormone receptors and negative HER2. Indeed, the analysis of gene expression profiles revealed that NEBC belongs mainly to the luminal subtype. Cases of HER2-positive...
Sun May 17, 2020 23:57
Related ArticlesPast, Present and Future of Epigenetics in Adrenocortical Carcinoma. Cancers (Basel). 2020 May 13;12(5): Authors: Ettaieb M, Kerkhofs T, van Engeland M, Haak H Abstract DNA methylation profiling has been suggested a reliable technique to distinguish between benign and malignant adrenocortical tumors, a process which with current diagnostic methods remains challenging and lacks diagnostic accuracy of borderline tumors. Accurate distinction...
Sun May 17, 2020 23:57
Estimation of the carrier frequency of fumarate hydratase alterations and implications for kidney cancer risk in hereditary leiomyomatosis and renal cancer. Cancer. 2020 May 15;: Authors: Shuch B, Li S, Risch H, Bindra RS, McGillivray PD, Gerstein M Abstract BACKGROUND: Hereditary leiomyomatosis and renal cancer (HLRCC) is a cancer syndrome associated with a germline mutation in fumarate hydratase (FH). The syndrome is associated with cutaneous and uterine...
Sat May 16, 2020 13:16
[Multicystic transformation of the post-radiation necrosis zone of the brain. A case report and literature review]. Zh Vopr Neirokhir Im N N Burdenko. 2020;84(2):72-82 Authors: Kosyrkova AV, Goryainov SA, Kravchuk AD, Golanov AV, Maryashev SA, Vetlova ER, Antipina NA, Pronin IN, Batalov AI, Zakharova NE, Potapov AA Abstract Post-radiation cyst of the brain is a rare complication that often arises many years after irradiation for head and neck neoplasms....
Sat May 16, 2020 13:16
Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers. J Oncol. 2020;2020:4659062 Authors: Lee SJ, Hong JY, Kim K, Kim KM, Kang SY, Lee T, Kim ST, Park SH, Park YS, Lim HY, Kang WK, Lee J, Park JO Abstract Successful identification and targeting of oncogenic gene fusion is a major breakthrough in cancer treatment. Here, we investigate the therapeutic implications and feasibility of using a targeted RNA sequencing...
Sat May 16, 2020 13:16
Geographic and temporal variations in the incidence of vulvar and vaginal cancers. Int J Cancer. 2020 May 14;: Authors: Bray F, Laversanne M, Weiderpass E, Arbyn M Abstract Vulvar and vaginal cancers are relatively rare cancers, together responsible for 1.5% of the global cancer incidence among women in 2018. The majority of vaginal cancers, and a lesser proportion of vulvar cancers are associated with HPV. Various reports have indicated rising incidence...
Sat May 16, 2020 13:16
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei of appendiceal origin: result of a single centre study. Updates Surg. 2020 May 14;: Authors: Di Leo A, Corvasce A, Weindelmayer J, Mason EJ, Casella F, de Manzoni G Abstract Pseudomyxoma peritonei (PMP) is a rare condition characterized by the intraperitoneal accumulation of mucus derived mostly by appendiceal mucinous neoplasm. Cytoreductive surgery...
Sat May 16, 2020 13:16
Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type. Clin Cancer Res. 2020 May 14;: Authors: Ji JX, Cochrane DR, Tessier-Cloutier B, Chen SY, Ho G, Pathak KV, Alcazar IN, Farnell D, Leung S, Cheng A, Chow C, Colborne S, Negri GL, Kommoss F, Karnezis A, Morin GB, McAlpine JN, Gilks B, Weissman BE, Trent JM, Hoang L, Pirrotte P, Wang Y, Huntsman...
Sat May 16, 2020 13:16
Neuroendocrine Carcinoma of the Uterine Cervix: A Clinicopathologic and Immunohistochemical Study with Focus on Novel Markers (Sst2-Sst5). Cancers (Basel). 2020 May 12;12(5): Authors: Inzani F, Santoro A, Angelico G, Feraco A, Spadola S, Arciuolo D, Valente M, Carlino A, Piermattei A, Scaglione G, Scambia G, Rindi G, Zannoni GF Abstract BACKGROUND: Gynecological neuroendocrine neoplasms (NENs) are extremely rare, accounting for 1.2-2.4% of the NENs....
Sat May 16, 2020 13:16
Related ArticlesPapillary thyroid microcarcinoma presenting as a metastasis to the brain. Ann R Coll Surg Engl. 2020 May;102(5):e107-e110 Authors: Shawky M, Proctor I, Kurzawinski T, Abdel-Aziz T Abstract The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures and dysphasia due to left frontal lobe cystic mass,...
Sat May 16, 2020 13:16
Related ArticlesSevere hypercalcaemia of primary hyperparathyroidism: Could giant adenoma be the real culprit rather than carcinoma? Ann R Coll Surg Engl. 2020 May;102(5):363-368 Authors: Gücek Haciyanli S, Acar N, Gür EÖ, Çelik SC, Karaıslı S, Dilek ON, Haciyanli M Abstract INTRODUCTION: Hypercalcaemic crisis is a rare manifestation of hyperparathyroidism and occurs in 1.6-6% of patients with primary hyperparathyroidism (pHPT). Although such high serum...
Sat May 16, 2020 13:16
Related ArticlesA splenic 'cyst': histology confirmed splenic sarcoma. Ann R Coll Surg Engl. 2020 May;102(5):e105-e106 Authors: Ashmore DL, Dasgupta D Abstract Primary malignant fibrous histiocytoma, now classified as pleomorphic undifferentiated sarcoma, is the most common soft-tissue sarcoma in adult life. Primary splenic pleomorphic undifferentiated sarcoma is extremely rare and aggressive, and is associated with a poor prognosis; only 14 cases of...
Sat May 16, 2020 13:16
Related ArticlesType VI choledochal cyst with gall bladder carcinoma. BMJ Case Rep. 2019 Dec 29;12(12): Authors: Vishwanath Reddych V, Kumar A, Aggarwal M, Kurdia KC Abstract An isolated dilatation of the cystic duct (type VI choledochal cyst (CDC)) is extremely rare with only 21 cases reported in the world literature until now. There is only one case of in situ gall bladder cancer (GBC) reported in association with type VI CDC in the literature. Here...
Sat May 16, 2020 13:16
Related ArticlesSignet-ring cell adenocarcinoma of unknown primary presenting with superior vena cava (SVC) syndrome: rare type of cancer. BMJ Case Rep. 2019 Dec 29;12(12): Authors: Bagaporo Larrazabal R, Cheng PVC, David-Wang A, Requiso D Abstract A 53-year-old man presented with a 3-month history of progressive, non-productive cough followed by occasional swelling of the face and upper extremities. Physical examination on admission revealed prominent...
Sat May 16, 2020 13:16
Related ArticlesSTEMI: rare initial presentation of a mediastinal mass supplied by the RCA. BMJ Case Rep. 2019 Dec 29;12(12): Authors: Claxton BB, Loloi J, Mrowczynski OD, Abdulbasit M Abstract In the setting of severe septic shock, a 70-year-old woman had an ST segment myocardial infarction with ST elevations in the inferolateral leads. On cardiac catheterisation, no obstructive pathology was noted. Chest imaging revealed a large mediastinal mass measuring...
Sat May 16, 2020 13:16
Related ArticlesClinical Characteristics and Outcomes of Acute Lung Injury Caused by Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Retrospective Cohort Study from a Single Institution in China. Anal Cell Pathol (Amst). 2019;2019:4307651 Authors: Fang LJ, Chen LY, Sun JH, Zhou JY Abstract Background: Acute lung injury (ALI) is a rare but life-threatening pulmonary complication of transcatheter arterial chemoembolization (TACE)...
Sat May 16, 2020 13:16
Related ArticlesEndoscopic resection of giant gastrointestinal stromal tumor at the esophagogastric junction: a case report. BMC Gastroenterol. 2019 Dec 27;19(1):227 Authors: Xue F, Wang W, Shi N, Ma XB, Liu CX Abstract BACKGROUND: Gastrointestinal stromal tumors (GISTs) at the esophagogastric junction are rare and its treatment is complicated and challenging. Endoscopic resection has advantages with less complications compared to open and laparoscopic...
Sat May 16, 2020 13:16
Related ArticlesFeatures of non-activation dendritic state and immune deficiency in blastic plasmacytoid dendritic cell neoplasm (BPDCN). Blood Cancer J. 2019 12 06;9(12):99 Authors: Beird HC, Khan M, Wang F, Alfayez M, Cai T, Zhao L, Khoury J, Futreal PA, Konopleva M, Pemmaraju N Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, male-predominant hematologic malignancy with poor outcomes and with just one recently approved agent...
Sat May 16, 2020 13:16
Related Articles[Distal Ileal Lymphoma Presenting Ileocecal Intussusception with Spontaneous Reduction]. Korean J Gastroenterol. 2019 Nov 25;74(5):291-294 Authors: Jang HY, Lee JY, Kim SH, Pak MG, Lee JH Abstract Intussusception is a rare disease in adults. A demonstrable etiology is found in approximately 85% of all cases, and approximately 40% of them are caused by malignant tumors. A 65-year-old patient visited the outpatient department with mild...
Sat May 16, 2020 13:16
Related ArticlesDefining the Genetics of Basosquamous Carcinoma. J Invest Dermatol. 2019 11;139(11):2258-2260 Authors: Tarapore E, Atwood SX Abstract Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway...
Sat May 16, 2020 13:16
Related ArticlesA rational approach to postoperative surveillance for resected non-functional pancreatic neuro-endocrine tumours. Pancreatology. 2019 Oct;19(7):1000-1007 Authors: Feretis M, Wang T, Ghorani E, Balakrishnan A, Harper SJ, Jah A, Huguet EL, Praseedom RK, Liau SS Abstract BACKGROUND: Non-functional pancreatic neuroendocrine tumours (NF-PNETs) are rare and have highly variable outcomes. Current guidelines recommend surveillance for NF-PNETs...
Sat May 16, 2020 13:16
Related ArticlesBiphasic squamoid alveolar renal carcinoma with positive CD57 expression: A clinicopathologic study of three cases. Pathol Int. 2019 Sep;69(9):519-525 Authors: Zhou L, Xu H, Zhou Y, Zhou J, Zhang P, Yang X, Wang C Abstract Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a rare and recently characterized form of papillary renal cell carcinoma (PRCC). Herein, we describe three cases of BSARCC that were CD57+. Among a total...
Sat May 16, 2020 13:16
Related ArticlesParaneoplastic phenomenon in mesothelioma. Thorax. 2019 07;74(7):719-720 Authors: Waqar AB, Menzies D, Casey M, Doran M Abstract A 71-year-old man presented with breathlessness and visual disturbance. On examination of the chest, he had signs suggestive of a right-sided pleural effusion and a neurological examination yielded conjugate vertical gaze palsy. Subsequent investigations revealed pleural thickening and mesothelioma. His anti-Ma2...
Sat May 16, 2020 13:16
Related ArticlesDanger hidden underneath: a rare esophageal subepithelial lesion. Endoscopy. 2019 08;51(8):E225-E226 Authors: Jin Y, Chengbo L, Qiuyuan W, Yuyong T, Deliang L PMID: 31049895 [PubMed - indexed for MEDLINE]
Sat May 16, 2020 13:16
Related ArticlesRemnant Gastric Cancer After Roux-en-Y Gastric Bypass: Narrative Review of the Literature. Obes Surg. 2019 08;29(8):2609-2613 Authors: Tornese S, Aiolfi A, Bonitta G, Rausa E, Guerrazzi G, Bruni PG, Micheletto G, Bona D Abstract BACKGROUND: The Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed procedures for surgical weight loss. It has been shown that overweight may be associated with an increased risk of gastric...
Sat May 16, 2020 13:16
Related ArticlesMolecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomas. J Hematol Oncol. 2019 03 15;12(1):29 Authors: Menyhárt O, Giangaspero F, Győrffy B Abstract Childhood medulloblastomas (MB) are heterogeneous and are divided into four molecular subgroups. The provisional non-wingless-activated (WNT)/non-sonic hedgehog-activated (SHH) category combining group 3 and group 4 represents over two...
Sat May 16, 2020 13:16
Related ArticlesSpontaneous massive haemothorax in the peri-partum period of an undiagnosed neurofibromatosis type 1 patient - A surgical perspective. Med J Malaysia. 2019 02;74(1):99-101 Authors: Narasimman S, Govindasamy H, Seevalingam KK, Paramasvaran G, Ramasamy U Abstract Acute massive haemothorax is a life-threatening situation, which is often associated with a preceding trauma. However, spontaneous haemothorax is a rare occurrence, especially...
Sat May 16, 2020 13:16
Related ArticlesParaneoplastic relapsing minimal change disease associated with type A thymoma in an elderly patient: A case report and literature review. Med J Malaysia. 2019 02;74(1):97-98 Authors: Ngoh CLY, Goh GHS, Wong WK Abstract Thymoma is a rare mediastinal tumour that can be accompanied by different paraneoplastic syndromes. Here we report a case of Type A thymoma associated with relapsing minimal change disease (MCD). This case highlights:...
Sat May 16, 2020 13:16
Related ArticlesPaediatric burkitt lymphoma presenting as a mandible swelling and intussusception. Med J Malaysia. 2019 02;74(1):90-91 Authors: Retinasekharan S, Sinnathamby P, Mohamad I Abstract Burkitt lymphoma is a rare entity especially in this part of the world. We had an 11-year-old patient presented with swelling of the mandible for a short one-month duration. He was planned for excision biopsy. However developed severe abdominal pain while in...
Sat May 16, 2020 13:16
Related ArticlesThe great masquerade: Empyema thoracis as an unusual presentation of primary lung malignancy. Med J Malaysia. 2019 02;74(1):79-81 Authors: Nyanti LE, Kho SS, Tie ST Abstract Primary lung malignancy presenting as empyema is rare, with a reported incidence of 0.3%. We report a case of a 60- year-old man presenting with unilateral pleural effusion; diagnostic thoracocentesis confirmed Salmonella empyema. Post-drainage, chest radiograph showed...
Sat May 16, 2020 13:16
Related ArticlesACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children. Eur J Cancer. 2019 03;110:74-85 Authors: Pearson ADJ, Scobie N, Norga K, Ligas F, Chiodin D, Burke A, Minard-Colin V, Adamson P, Marshall LV, Balakumaran A, Benettaib B, Bhargava P, Bollard CM, Bolotin E, Bomken S, Buechner J, Burkhardt B, Caron H, Copland C, Demolis P, Egorov A, Farhan M, Zugmaier G, Gross T,...
Sat May 16, 2020 13:16
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