The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations. Cancer Cell Int. 2020;20:154 Authors: Lin Y, Qi X, Liu H, Xue K, Xu S, Tian Z Abstract Fucoidan is a kind of the polysaccharide, which comes from brown algae and comprises of sulfated fucose residues. It has shown a large range of biological activities in basic researches, including many elements like anti-inflammatory, anti-cancer, anti-viral, anti-oxidation,...
Sat May 16, 2020 13:21
Graphene oxide suppresses the growth and malignancy of glioblastoma stem cell-like spheroids via epigenetic mechanisms. J Transl Med. 2020 May 14;18(1):200 Authors: Wang X, Zhou W, Li X, Ren J, Ji G, Du J, Tian W, Liu Q, Hao A Abstract BACKGROUND: Glioblastoma stem-like cells (GSCs) are hypothesized to contribute to self-renewal and therapeutic resistance in glioblastoma multiforme (GBM) tumors. Constituting only a small percentage of cancer cells,...
Sat May 16, 2020 13:21
MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis. Mol Med. 2020 May 14;26(1):46 Authors: Chen YL, Sheu JJ, Sun CK, Huang TH, Lin YP, Yip HK Abstract BACKGROUND: MicroRNAs control gene expression by post-transcriptional inhibition. Dysregulation of the expressions of miR-199a/214 cluster has been linked to cardiovascular diseases. This study aimed at identifying potential microRNAs related to vascular...
Sat May 16, 2020 13:21
Plumbagin-Serum Albumin Interaction: Spectral, Electrochemical, Structure-Binding Analysis, Anti-proliferative and Cell Signaling Aspects with Implications for Anticancer Therapy. ChemMedChem. 2020 May 14;: Authors: Baron V, Chrastina A, Welsh J, Rondeau G, Abedinpour P, Borgstrom P Abstract Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a small molecule with potent anticancer activity. Like other 1,4-naphthoquinones, it exhibits electrophilic...
Sat May 16, 2020 13:21
Fisetin induces apoptosis in uterine leiomyomas through multiple pathways. Sci Rep. 2020 May 14;10(1):7993 Authors: Lee JW, Choi HJ, Kim EJ, Hwang WY, Jung MH, Kim KS Abstract Although uterine leiomyomas are the most common benign uterine tumors in women, there is no effective therapy that can also preserve the uterus and maintain fertility. The work aimed to work was to discover a potential natural agent that has pharmacological activities on uterine...
Sat May 16, 2020 13:21
Cuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer. Cell Death Dis. 2020 May 14;11(5):366 Authors: Xiong Q, Liu A, Ren Q, Xue Y, Yu X, Ying Y, Gao H, Tan H, Zhang Z, Li W, Zeng S, Xu C Abstract Cisplatin-based chemotherapy is the first-line treatment for patients with advanced bladder cancer. However, as more than 50% of patients are ineligible for cisplatin-based...
Sat May 16, 2020 13:21
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nat Commun. 2020 May 14;11(1):2401 Authors: Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C Abstract ...
Sat May 16, 2020 13:21
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. Cells. 2020 May 12;9(5): Authors: Bidault G, Garcia M, Capeau J, Morichon R, Vigouroux C, Béréziat V Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA p.G608G splice variant that leads to the expression...
Sat May 16, 2020 13:21
Related ArticlesMortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers. J Exp Clin Cancer Res. 2019 Dec 19;38(1):499 Authors: Putri JF, Bhargava P, Dhanjal JK, Yaguchi T, Sundar D, Kaul SC, Wadhwa R Abstract BACKGROUND: Mortalin is enriched in a large variety of cancers and has been shown to contribute to proliferation and migration of cancer cells in multiple ways. It has been shown...
Sat May 16, 2020 13:21
Related ArticlesLong non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness. Cell Death Dis. 2019 03 20;10(4):270 Authors: Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H, Kwong A Abstract Triple-negative breast cancer (TNBC) is a malignant subtype of breast cancer with the absence of targeted therapy, resulting in poor prognosis in patients. Chemotherapy remains the...
Sat May 16, 2020 13:21
Related ArticlesIsoalantolactone inhibits IKKβ kinase activity to interrupt the NF-κB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma. Cancer Med. 2019 04;8(4):1655-1670 Authors: Xing JS, Wang X, Lan YL, Lou JC, Ma B, Zhu T, Zhang H, Wang D, Yu Z, Yuan Z, Li XY, Zhang B Abstract Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and...
Sat May 16, 2020 13:21
Related ArticlesLow expression of PDK1 inhibits renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition through inhibition of the PI3K-PDK1-Akt pathway. Cell Signal. 2019 04;56:1-14 Authors: Zhou WM, Wu GL, Huang J, Li JG, Hao C, He QM, Chen XD, Wang GX, Tu XH Abstract As the most commonly occurring form of primary renal tumor, renal cell carcinoma (RCC) is a malignancy accompanied by a high mortality rate....
Sat May 16, 2020 13:21
The impact of calmodulin on the cell cycle analyzed in a novel human cellular genetic system. Cell Calcium. 2020 Apr 30;88:102207 Authors: Munk M, Alcalde J, Lorentzen L, Villalobo A, Berchtold MW, Panina S Abstract Calmodulin (CaM) is the principle mediator of the Ca2+ signal in all eukaryotic cells. A huge variety of basic cellular processes including cell cycle control, proliferation, secretion and motility, among many others are governed by CaM,...
Fri May 15, 2020 13:09
Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from Penicillium aurantiacobrunneum. Biomed Pharmacother. 2020 May 11;127:110124 Authors: Anaya-Eugenio GD, Tan CY, Rakotondraibe LH, Carcache de Blanco EC Abstract Colorectal cancer is the third leading cause of cancer related-death in the United States. Search for new alternatives to treat this type of cancer is necessary. In a previous report, auransterol from Penicillium...
Fri May 15, 2020 13:09
Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway. Life Sci. 2020 May 11;:117695 Authors: Ban L, Mei T, Su Q, Li W, Huang Z, Liu L, Wu Y, Lv S, Wang A, Li S Abstract AIMS: To investigate the therapeutic potential of itraconazole in oral squamous cell carcinoma (OSCC) and its molecular mechanism. MATERIALS AND METHODS: The in vitro anti-cancer effects of itraconazole...
Fri May 15, 2020 13:09
Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer. Arch Biochem Biophys. 2020 May 11;:108407 Authors: Park S, Kwon W, Park JK, Baek SM, Lee SW, Cho GJ, Ha YS, Lee JN, Kwon TG, Kim MO, Ryoo ZY, Han SH, Han JE, Choi SK Abstract Prostate cancer has the highest incidence among men in advanced countries, as well as a high mortality rate. Despite the efforts of numerous researchers...
Fri May 15, 2020 13:09
miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis. Med Sci Monit. 2020 May 14;26:e923559 Authors: Qiang Y, Feng L, Wang G, Liu J, Zhang J, Xiang L, Su C, Zhang S, Xie X, Chen E Abstract BACKGROUND MicroRNAs (miRNAs) have a significant regulatory effect on the proliferation, migration, and invasion of cells, and have been widely reported to have oncogenic or tumor-suppressive impacts...
Fri May 15, 2020 13:09
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820926591 Authors: Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, Yuan X, Sha Q Abstract Desloratadine, a potent antagonist for human histamine H1 receptor, has been revealed to exhibit antihistaminic activity and anti-inflammatory activity. However, it is not yet known whether desloratadine has any effect on the biological behaviors of tumor...
Fri May 15, 2020 13:09
Blocking ACAT-1 Activity for Tumor Therapy with Fluorescent Hyperstar Polymer-Encapsulated Avasimible. Macromol Biosci. 2020 May 13;:e1900438 Authors: Bai T, Zhu B, Shao D, Lian Z, Liu P, Shi J, Kong J Abstract Targeting the distinct cholesterol metabolism of tumor cells is proposed as a novel way to treat tumors. Blocking acyl-CoA cholesterol acyltransferase-1 (ACAT-1) by the inhibitor avasimible (Ava), which elevates intracellular free cholesterol...
Fri May 15, 2020 13:09
Quinacrine inhibits GSTA1 activity and induces apoptosis through G1/S arrest and generation of ROS in human non-small cell lung cancer cell lines. Oncotarget. 2020 May 05;11(18):1603-1617 Authors: Kumar M, Martin A, Nirgude S, Chaudhary B, Mondal S, Sarkar A Abstract BACKGROUND: Quinacrine (QC) is popular for its anti-malarial activity. It has been reported exhibiting anti-cancerous properties by suppressing nuclear factor-κB and activating p53 signaling;...
Fri May 15, 2020 13:09
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. Pharmacol Res. 2020 May 13;:104901 Authors: Cheong DHJ, Daniel Tan WS, Fred Wong WS, Tran T Abstract Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase...
Fri May 15, 2020 13:09
Genetic landscape and ligand-dependent activation of sonic hedgehog-Gli1 signaling in chordomas: a novel therapeutic target. Oncogene. 2020 May 14;: Authors: Yang C, Yong L, Liang C, Li Y, Ma Y, Wei F, Jiang L, Zhou H, He G, Pan X, Hai B, Wu J, Xu Y, Liu Z, Liu X Abstract Chordoma, a rare neoplasm derived from intraosseous notochordal remnants, is unresponsive to conventional chemotherapy and radiotherapy. Sonic Hedgehog (Shh) is a crucial fetal...
Fri May 15, 2020 13:09
SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle. Oncogene. 2020 May 13;: Authors: Lu YF, Xu XP, Lu XP, Zhu Q, Liu G, Bao YT, Wen H, Li YL, Gu W, Zhu WG Abstract Sirtuin 7 (SIRT7), an NAD+-dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycle arrest during glucose deprivation....
Fri May 15, 2020 13:09
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer. Acta Pharmacol Sin. 2020 May 13;: Authors: Chen XL, Liu P, Zhu WL, Lou LG Abstract Hsp90 is a potential therapeutic target for tumor, as it maintains the stability of a variety of proteins related to tumor development and progression. Autophagy is a self-degradation process to maintain cellular homeostasis and autophagy inhibitors can suppress...
Fri May 15, 2020 13:09
Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins. Vet Res. 2020 May 13;51(1):65 Authors: Lu M, Tian X, Yang Z, Wang W, Tian AL, Li C, Yan R, Xu L, Song X, Li X Abstract Haemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of...
Fri May 15, 2020 13:09
Related ArticlesSnail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint. PLoS Biol. 2020 02;18(2):e3000609 Authors: Zeng J, Huynh N, Phelps B, King-Jones K Abstract The final body size of any given individual underlies both genetic and environmental constraints. Both mammals and insects use target of rapamycin (TOR) and insulin signaling pathways...
Fri May 15, 2020 13:09
Related ArticlesFunctional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms. J Microbiol. 2020 Feb;58(2):81-91 Authors: Choi JE, Chung WH Abstract The DNA damage checkpoint signaling pathway is a highly conserved surveillance mechanism that ensures genome integrity by sequential activation of protein kinase cascades. In mammals, the main pathway is orchestrated by two central...
Fri May 15, 2020 13:09
Related ArticlesDownregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process Impairment. Asian Pac J Cancer Prev. 2019 Dec 01;20(12):3679-3687 Authors: Assani G, Segbo J, Yu X, Yessoufou A, Xiong Y, Zhou F, Zhou Y Abstract BACKGROUND: Radioresistance remains a challenge for cancer radiotherapy. The present study aims to investigate the role of TMPRSS4 in triple negative breast cancer...
Fri May 15, 2020 13:09
Related ArticlesTopoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum. Int J Parasitol Drugs Drug Resist. 2019 12;11:39-48 Authors: Gutiérrez-Corbo C, Álvarez-Velilla R, Reguera RM, García-Estrada C, Cushman M, Balaña-Fouce R, Pérez-Pertejo Y Abstract DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines,...
Fri May 15, 2020 13:09
Related Articles2020 consensus guideline for optimal approach to the diagnosis and treatment of HER2-positive breast cancer in Bosnia and Herzegovina. Bosn J Basic Med Sci. 2020 May 16;: Authors: Bešlija S, Gojković Z, Cerić T, Mekić Abazović A, Marijanović I, Vranić S, Mustedanagić-Mujanović J, Skenderi F, Rakita I, Guzijan A, Koprić D, Humačkić A, Trokić D, Alidžanović J, Efendić A, Šišić I, Drljević H, Bešlagić V, Babić B, Pašić A, Ramić A, Mikić D, Guzin Z, Karan...
Sun May 17, 2020 23:49
Related ArticlesNeuroendocrine Cancer of the Breast: A Rare Entity. J Clin Med. 2020 May 13;9(5): Authors: Irelli A, Sirufo MM, Morelli L, D'Ugo C, Ginaldi L, De Martinis M Abstract Neuroendocrine breast cancer (NEBC) is a rare histotype of breast carcinoma that presents, in most cases, positive hormone receptors and negative HER2. Indeed, the analysis of gene expression profiles revealed that NEBC belongs mainly to the luminal subtype. Cases of HER2-positive...
Sun May 17, 2020 23:49
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer. NPJ Breast Cancer. 2020;6:17 Authors: Kos Z, Roblin E, Kim RS, Michiels S, Gallas BD, Chen W, van de Vijver KK, Goel S, Adams S, Demaria S, Viale G, Nielsen TO, Badve SS, Symmans WF, Sotiriou C, Rimm DL, Hewitt S, Denkert C, Loibl S, Luen SJ, Bartlett JMS, Savas P, Pruneri G, Dillon DA, Cheang MCU, Tutt A, Hall JA, Kok M, Horlings HM, Madabhushi A, van der Laak J, Ciompi F, Laenkholm...
Sat May 16, 2020 16:03
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group. NPJ Breast Cancer. 2020;6:16 Authors: Amgad M, Stovgaard ES, Balslev E, Thagaard J, Chen W, Dudgeon S, Sharma A, Kerner JK, Denkert C, Yuan Y, AbdulJabbar K, Wienert S, Savas P, Voorwerk L, Beck AH, Madabhushi A, Hartman J, Sebastian MM, Horlings HM, Hudeček J, Ciompi F, Moore DA, Singh R, Roblin E, Balancin ML, Mathieu MC, Lennerz JK, Kirtani...
Sat May 16, 2020 16:03
Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study. J Immunol Res. 2020;2020:3948928 Authors: Li YC, Zhou Q, Song QK, Wang RB, Lyu S, Guan X, Zhao YJ, Wu JP Abstract Purpose: The immune checkpoint inhibitor is approved for breast cancer treatment, but the low expression of PD-L1 limits the immunotherapy. CD155 is another immune checkpoint...
Sat May 16, 2020 16:03
Tumour-infiltrating lymphocytes and response to neoadjuvant letrozole in patients with early oestrogen receptor-positive breast cancer: analysis from a nationwide phase II DBCG trial. Breast Cancer Res. 2020 May 14;22(1):46 Authors: Skriver SK, Jensen MB, Knoop AS, Ejlertsen B, Laenkholm AV Abstract BACKGROUND: The presence of tumour-infiltrating lymphocytes (TILs) is associated with response to neoadjuvant chemotherapy among patients with triple-negative...
Sat May 16, 2020 16:03
Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer. Mol Cancer Ther. 2020 May 13;: Authors: Zazo S, González-Alonso P, Martin-Aparicio E, Chamizo C, Luque M, Sanz-Alvarez M, Mínguez P, Gómez-López G, Cristobal I, Caramés C, García-Foncillas J, Eroles P, Lluch A, Arpí O, Rovira A, Albanell J, Madoz-Gúrpide J, Rojo F Abstract HER2-positive breast cancer is currently managed with chemotherapy in...
Fri May 15, 2020 16:09
Related ArticlesWhen cancer encounters COVID-19 in China: what have we suffered, experienced and learned. Jpn J Clin Oncol. 2020 May 16;: Authors: Chen H, Wu X, Wang W, Wang Q Abstract The outbreak of the coronavirus disease (COVID-19) occurred in Wuhan, China, in December 2019. As of 21 March 2020, this epidemic has spread to 179 countries with more than 200 000 confirmed cases and 8578 deaths. The outbreak has put enormous pressure on the medical establishment...
Sun May 17, 2020 23:45
Related ArticlesOutcomes after thoracoscopic surgery in octogenarian patients with clinical N0 non-small-cell lung cancer. Jpn J Clin Oncol. 2020 May 18;: Authors: Nakao M, Ichinose J, Matsuura Y, Okumura S, Mun M Abstract OBJECTIVE: The number of surgeries for elderly patients with lung cancer is increasing. In our institute, thoracoscopic lobectomy and hilar lymph node dissection are the standard procedure for octogenarian patients with clinical N0...
Sun May 17, 2020 23:45
Study on the prevention of infection in terminal cancer patients applying epidural analgesia by adding cefazolin to anesthetics: a randomized controlled trial. Jpn J Clin Oncol. 2020 May 15;: Authors: Xie P, Li Z, Yang J, Wu Y Abstract OBJECTIVE: To observe the antibacterial effect of adding cefazolin into anesthetics in patients with terminal cancer undergoing long-term epidural analgesia. METHODS: Patients undergoing epidural analgesia with...
Sat May 16, 2020 13:37
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου