BACKGROUND AND PURPOSE:Transient global amnesia (TGA) is a sudden onset of anterograde and retrograde amnesia. We aimed to assess differences in terms of cortical thickness and structural brain connectome between patients with TGA (at acute and delayed postrecovery stages) and matched controls. MATERIALS AND METHODS:We report on 18 consecutive patients with TGA who underwent 3T MR imaging, including DTI and MPRAGE sequences, at the acute (mean delay postonset: 44 hours) and delayed post-recovery...
Fri May 15, 2020 20:28
SUMMARY:Pathogenic variants in the polymerase gene (POLG) cause a diverse group of pathologies known as POLG-related disorders. In this report, we describe brain MR imaging findings and electroencephalogram correlates of 13 children with POLG-related disorders at diagnosis and follow-up. At diagnosis, all patients had seizures and 12 had abnormal MR imaging findings. The most common imaging findings were unilateral or bilateral perirolandic (54%) and unilateral or bilateral thalamic signal changes...
Fri May 15, 2020 20:28
BACKGROUND AND PURPOSE:Recent studies showed thalamic atrophy in the early stages of MS. We investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in MS. MATERIALS AND METHODS:Seventy-one patients with MS were included. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR, respectively, by using 3D Slicer. Volumes of white matter T1 hypointensities...
Fri May 15, 2020 20:28
BACKGROUND AND PURPOSE:The inhomogeneous magnetization transfer technique has demonstrated high specificity for myelin, and has shown sensitivity to multiple sclerosis-related impairment in brain tissue. Our aim was to investigate its sensitivity to spinal cord impairment in MS relative to more established MR imaging techniques (volumetry, magnetization transfer, DTI). MATERIALS AND METHODS:Anatomic images covering the cervical spinal cord from the C1 to C6 levels and DTI, magnetization transfer/inhomogeneous...
Fri May 15, 2020 20:28
BACKGROUND AND PURPOSE:Though CT is a highly calibrated imaging modality, head CT is typically interpreted qualitatively. Our aim was to initiate the establishment of a reference quantitative database for clinical head CT. MATERIALS AND METHODS:An automated segmentation algorithm was developed and applied to 354 clinical head CT scans with radiographically normal findings (ages, 18–101 years; 203 women) to measure brain volume, brain parenchymal fraction, brain radiodensity, and brain parenchymal...
Fri May 15, 2020 20:28
Abstract Background Endocrine neoplasms are generally slow-growing tumors that can show hormonal activity and give metastases. In most cases they are benign and clearly malignant forms are easy to diagnose. However, borderline forms may occur and be, for the pathologists, very difficult to classify. In these cases, there is a strong need to identify factors that may aid. Official classification systems for endocrine neoplasms are based...
Fri May 15, 2020 03:00
Publication date: May 2020Source: Journal of Phonetics, Volume 80Author(s):
Fri May 15, 2020 18:58
Abstract Background Difference in the functional orthopedic effect between stepwise mandibular advancement (SWA) and single-step mandibular advancement (SSA) in Angle class II patients remains unclarified. Objective To compare the treatment effects of SWA and SSA on skeletal and dentoalveolar changes in class II patients. ...
Fri May 15, 2020 03:00
Despite a plethora of articles describing airway assessment, there is no magic bullet for difficult airway evaluation. Statistical validation of scoring systems and radiological evaluations appear to be elusive. The reason for our inability to reliably assess every airway is complex. Every airway has a subset of subtly different anatomical variables and when taken in totality may result in Difficult Bag Mask ventilation (DBMV) or Difficult Intubation (DI). Simply looking at five to 12 risk factors...
Fri May 15, 2020 03:00
SUMMARY Mutational activation of RAC1 is detected in ~7% of cutaneous melanoma, with the most frequent mutation (RAC1C85T) encoding for RAC1P29S. RAC1P29S is a fast‐cycling GTPase that leads to accumulation of RAC1P29S‐GTP, which has potentially pleiotropic regulatory functions in melanoma cell signaling and biology. However, the precise mechanism by which mutationally activated RAC1P29S propagates its pro‐tumorigenic effects remains unclear. RAC1‐GTP is reported to activate the beta isoform of...
Thu May 14, 2020 15:14
Abstract Melanomas are skin tumors that show a variety of biological behavior. Some develop very fast and some other grow extremely slow, with metastasis appearing, eventually, many years after the diagnosis. The number of mitoses in primary melanoma has been related to a more aggressive tumor and may have a potential as predictive factor for cutaneous melanoma survival. However tumor mitotic rate is a static measure and in multivariate analysis on tumor survival it has scored less than other tumor...
Thu May 14, 2020 14:24
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. Massachusetts quickly followed New York in becoming an epicenter of…
Fri May 15, 2020 03:00
As the United States navigates one of the most serious pandemics in history, much of the country has been shut down to prevent devastating local outbreaks that threaten lives and can overwhelm hospitals. A breakdown in the federal disaster response delayed state and local responses, allowing…
Fri May 15, 2020 03:00
The rapid spread of SARS-CoV-2, a novel coronavirus that emerged in late 2019, and the resulting Covid-19 disease has been labeled a Public Health Emergency of International Concern by the World Health Organization. What physicians need to know about transmission, diagnosis, and treatment is the…
Thu May 14, 2020 03:00
Publication date: Available online 15 May 2020Source: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-facialeAuthor(s): E. Lescanne, N. van der Mee-Marquet, J.-M. Juvanon, A. Abbas, N. Morel, J.-M. Klein, M. Hanau, V. Couloigner
Fri May 15, 2020 16:56
Publication date: Available online 14 May 2020Source: Human PathologyAuthor(s): Matthew J. Woge, Jay H. Ryu, Brian J. Bartholmai, Eunhee S. Yi
Fri May 15, 2020 16:52
Abstract Precision medicine using multi-marker tumor panel (MMTP) testing can help inform cancer treatment decisions. Oncologists’ knowledge of these tests and their ability to find up-to-date information about their application in clinical care is essential. This study aimed to (1) describe information sources used by oncologists to learn about new genomic tests and (2) examine characteristics associated with the use of each information source. The National Cancer Institute’s...
Fri May 15, 2020 03:00
The original version of this article unfortunately contained mistakes.
Fri May 15, 2020 03:00
Feasibility of Early Discharge after Open Hypopharyngeal Surgery for Dysphagia. Ann Otol Rhinol Laryngol. 2020 May 14;:3489420916216 Authors: Patel J, Spiegel J, Topf MC, Boon M, Huntley C Abstract OBJECTIVE: To determine the rate of surgical complications, unplanned readmission, and functional status after open hypopharyngeal surgery for dysphagia with early return to oral diet and hospital discharge. METHODS: Retrospective chart review...
Fri May 15, 2020 16:45
Spontaneous Internal Anal Sphincter Relaxation During High-resolution Anorectal Manometry Is Associated With Peripheral Neuropathy and Higher Charlson Comorbidity Scores in Patients With Defecatory Disorders. J Neurogastroenterol Motil. 2020 May 14;: Authors: Lee TH, Lee JS, Kim J, Kim JO, Kim HG, Jeon SR, Hong SJ, Cho YS, Park S Abstract Background/Aims: We aim to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal...
Fri May 15, 2020 16:42
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the substance (triethanolamine‐perchlorate, sodium salt) dimer, FCM substance No 1080, intended to be used as a thermal stabiliser at up to 0.15% w/w in rigid poly(vinyl chloride) (PVC) for repeated use bottles in contact with water. No thermal degradation of the substance is expected during the manufacture of the PVC articles. In water, the substance fully dissociates into triethanolamine,...
Fri May 15, 2020 11:05
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on barley starch to be used in the manufacturing of several foods as ingredient, of the food additive modified starch and of glucose syrups pursuant to Article 21(2) of Regulation (EU) No 1169/2011, as notified by Lyckeby Starch AB. The applicant provided information on the manufacturing process and data on the content of total protein,...
Fri May 15, 2020 11:04
Abstract The food enzyme cyclomaltodextrin glucanotransferase ((1→4)‐α‐d‐glucan:(1→4)‐α‐d‐glucan 4‐α‐d‐[(1→4)‐α‐d‐glucano]‐transferase; EC 2.4.1.19) is produced with the non‐genetically modified Paenibacillus illinoisenis strain 107 by Hayashibara Co., Ltd. The cyclomaltodextrin glucanotransferase food enzyme is intended to be used solely by the applicant in‐house in starch processing for trehalose production. Since residual amounts of total organic solids (TOS) are removed by the purification steps...
Fri May 15, 2020 11:04
Abstract The applicant Bayer Crop Science submitted a request to the competent national authority in the Netherlands to evaluate the confirmatory data that were identified for aclonifen in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gaps, an analytical method for enforcement in complex/no group matrices (spices) and additional four residue trials supporting SEU authorisation on peppers were submitted....
Fri May 15, 2020 11:02
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of dried whole cell Euglena gracilis as a novel food (NF) pursuant to Regulation (EU) 2015/2283. E. gracilis is a single‐cell microalga which occurs widely in nature and is commonly found in freshwater habitats. The NF, the dried biomass of E. gracilis, is produced by fermentation and its major constituent (> 50%) is a β‐glucan...
Thu May 14, 2020 22:00
Safety of 3’‐Sialyllactose (3’‐SL) sodium salt as a novel food pursuant to Regulation (EU) 2015/2283
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 3’‐Sialyllactose (3’‐SL) sodium salt as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human identical milk oligosaccharide (HiMO) 3’‐SL but also containing D‐lactose, sialic acid and a small fraction of other related oligosaccharides resulting in a fully characterised mixture of carbohydrates. The...
Thu May 14, 2020 22:00
Safety of 6′‐Sialyllactose (6′‐SL) sodium salt as a novel food pursuant to Regulation (EU) 2015/2283
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 6′‐Sialyllactose (6′‐SL) sodium salt as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) 6′‐SL but also contains D‐lactose, sialic acid and a small fraction of other related oligosaccharides. The NF is produced by fermentation with a genetically modified...
Thu May 14, 2020 22:00
Abstract Oilseed rape MS11 has been developed to confer male sterility and tolerance to glufosinate‐ammonium‐containing herbicides. Based on the information provided in the application and in line with the scope of application EFSA‐GMO‐BE‐2016‐138, the genetically modified organism (GMO) Panel concludes that the molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic characteristics...
Thu May 14, 2020 22:00
Background Visualization and instrumentation of the frontal sinus is not always possible with a Draf III or modified endoscopic Lothrop procedure (MELP), and external incisions can help augment exposure. We compare lateral frontal sinus access using only a MELP compared to the adjunctive transcaruncular approach and transcutaneous Lynch incision. Methods Twelve cadaveric heads underwent thin‐cut computed tomography scanning. Measurement of the frontal beak, anteroposterior depth of the frontal...
Thu May 14, 2020 21:19
Background Mast‐cell activation syndrome (MCAS) is increasingly recognized. Sinonasal obstruction is common among these patients. There is a paucity of literature describing the characteristics of MCAS and treatment outcomes. Methods Retrospective review of 192 patients with nasal congestion July 2017 to May 2019 among 3 providers (1 allergist, 2 rhinologists) was conducted. Suspected MCAS criteria were as follows: (1) at least 2 recurrent severe symptoms in addition to nasal congestion: flushing,...
Thu May 14, 2020 21:09
Abstract Background : Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of SARS‐CoV‐2 infection. However, their prevalence in different patient populations still needs to be clarified. Methods : A cross‐sectional study was performed from March 27 to April 1 2020 in Northern Italy. Physicians administered a survey‐based questionnaire to SARS‐CoV‐2 positive patients with the aim of assessing symptoms, focusing on OD and GD. Two groups were studied: patients...
Thu May 14, 2020 21:04
Publication date: Available online 14 May 2020Source: Clinical TherapeuticsAuthor(s): Tabassum Salam, Amy Duhig, Aarti A. Patel, Ann Cameron, Jennifer Voelker, Brahim Bookhart, Craig I. Coleman
Fri May 15, 2020 16:28
COVID-19-Associated Leukoencephalopathy. Radiology. 2020 May 14;:201753 Authors: Sachs JR, Gibbs KW, Swor DE, Sweeney AP, Williams DW, Burdette JH, West TG, Geer CP PMID: 32407258 [PubMed - as supplied by publisher]
Fri May 15, 2020 16:03
Assessing the Value of Diagnostic Tests in the New World of COVID-19 Pandemic. Radiology. 2020 May 14;:201845 Authors: Sardanelli F, Di Leo G PMID: 32407257 [PubMed - as supplied by publisher]
Fri May 15, 2020 16:03
Acute Pulmonary Embolism and COVID-19. Radiology. 2020 May 14;:201955 Authors: Poyiadi N, Cormier P, Patel PY, Hadied MO, Bhargava P, Khanna K, Nadig J, Keimig T, Spizarny D, Reeser N, Klochko C, Peterson EL, Song T PMID: 32407256 [PubMed - as supplied by publisher]
Fri May 15, 2020 16:03
Clinical and Chest Radiography Features Determine Patient Outcomes In Young and Middle Age Adults with COVID-19. Radiology. 2020 May 14;:201754 Authors: Toussie D, Voutsinas N, Finkelstein M, Cedillo MA, Manna S, Maron SZ, Jacobi A, Chung M, Bernheim A, Eber C, Concepcion J, Fayad Z, Gupta YS Abstract Background Chest radiography (CXR) has not been validated for its prognostic utility in evaluating patients with coronavirus disease 2019 (COVID-19)....
Fri May 15, 2020 16:03
Challenges in oral radiology teaching during COVID-19 pandemic. Dentomaxillofac Radiol. 2020 May 14;:20200178 Authors: Pontual MLA, do Nascimento EHL, da Cruz Perez DE, Pontual AA, Ramos-Perez FM PMID: 32406750 [PubMed - as supplied by publisher]
Fri May 15, 2020 15:35
Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis. Tohoku J Exp Med. 2020;251(1):9-18 Authors: Kondo N, Fujisawa J, Endo N Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic articular and bone manifestations and its pathogenesis is driven by a complex network of proinflammatory cytokines, including tumor necrosis factor and interleukin (IL)-6. Treatment of rheumatoid arthritis...
Fri May 15, 2020 15:03
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