Hyperdense suprasellar mass: An unusual radiological presentation of intracranial dermoid cyst.

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Hyperdense suprasellar mass: An unusual radiological presentation of intracranial dermoid cyst.

J Clin Neurosci. 2015 Jul;22(7):1208-10

Authors: Tan LA, Kasliwal MK, Harbhajanka A, Kellogg RG, Arvanitis LD, Munoz LF

Abstract
We report an exceedingly rare patient with a hyperdense suprasellar dermoid cyst and a pertinent review of the literature. Intracranial dermoid tumors are rare congenital lesions of the brain that account for less than 1% of all intracranial tumors. Even though they are rare, typical CT scan and MRI features and location allow radiological diagnosis in the majority of patients. Radiologically, dermoid cysts typically present as low density masses on CT scan and are generally hyperintense on T1-weighted MRI sequences with variable signal on T2-weighted sequences. The recognition of atypical features can avoid diagnostic pitfalls and is clinically relevant for overall surgical management.

PMID: 25865027 [PubMed - indexed for MEDLINE]

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Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.

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Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge.

J Clin Neurosci. 2015 Jul;22(7):1188-90

Authors: Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN

Abstract
We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with isolated ipsilateral facial pain mimicking trigeminal neuralgia due to invasion of Meckel's cave but subsequently progressing to intra-axial extension and having synchronous features of systemic lymphoma. Primary central nervous system lymphoma is uncommon, accounting for approximately 2% of all primary intracranial tumors, but its incidence has been steadily increasing in some groups [1]. It usually arises in the periventricular cerebral white matter, and reports of lymphoma in extra-axial regions are rare [2]. This man highlights the importance of maintaining lymphoma in the differential diagnosis of tumors of the skull base presenting with trigeminal neuralgia-like symptoms.

PMID: 25865026 [PubMed - indexed for MEDLINE]

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Hypertrophic olivary degeneration secondary to pontine haemorrhage.

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Hypertrophic olivary degeneration secondary to pontine haemorrhage.

J Clin Neurosci. 2015 Jul;22(7):1213-4

Authors: Wein S, Yan B, Gaillard F

Abstract
We report a 58-year-old man who developed hyptertrophic olivary degeneration (HOD) after haemorrhage of a cavernous malformation in the pons. Lesions of the triangle of Guillain and Mollaret (the dentatorubro-olivary pathway) may lead to HOD, a secondary transsynaptic degeneration of the inferior olivary nucleus. HOD is considered unique because the degenerating olive initially becomes hypertrophic rather than atrophic. The primary lesion causing pathway interruption is often haemorrhage, either due to hypertension, trauma, surgery or, as in our patient, a vascular malformation such as a cavernoma. Ischaemia and demyelination can also occasionally be the inciting events. The classic clinical presentation of HOD is palatal myoclonus, although not all patients with HOD develop this symptom. The imaging features of HOD evolve through characteristic phases. The clue to the diagnosis of HOD is recognition of the distinct imaging stages and identification of a remote primary lesion in the triangle of Guillain and Mollaret. Familiarity with the classic imaging findings of this rare phenomenon is necessary in order to avoid misdiagnosis and prevent unnecessary intervention.

PMID: 25863998 [PubMed - indexed for MEDLINE]

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Extreme volume expansion of a vestibular schwannoma due to intratumoral hemorrhage after gamma knife radiosurgery.

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Extreme volume expansion of a vestibular schwannoma due to intratumoral hemorrhage after gamma knife radiosurgery.

J Clin Neurosci. 2015 Jul;22(7):1196-9

Authors: Miki S, Ishikawa E, Yamamoto T, Akutsu H, Matsuda M, Sakamoto N, Matsumura A

Abstract
A 48-year-old man with right hemi-facial palsy and cerebellar ataxia was referred to our hospital. Three years and 10 months earlier he had undergone gamma knife radiosurgery (GKRS) at the referring hospital for an 18 mm right vestibular schwannoma. Slight tumor enlargement had been observed on MRI performed at the referring hospital 3 years after the GKRS. On close follow-up after another 6 months an MRI showed an obvious enlargement of the tumor. An MRI on admission revealed an iso-intense mass lesion measuring 36 mm in maximum diameter at the right cerebellopontine angle. A two stage surgery was conducted using a retrosigmoid approach because bleeding from the tumor wall was difficult to control intraoperatively during the first operation. At the second operation, the majority of the tumor capsule had converted to necrotic tissue. A large hematoma cavity was present inside the tumor capsule which explained the rapid increase in size over a short period of time. Near total removal was achieved. Histopathological examination revealed massive intratumoral hemorrhage within a typical vestibular schwannoma with no malignancy. The complication of intratumoral hemorrhage is very rare and the utility of stereotactic radiation surgery/therapy, including GKRS, for vestibular schwannoma is well known. However, we must emphasize that careful follow-up is still required, even after several years.

PMID: 25840877 [PubMed - indexed for MEDLINE]

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Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!

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Asymmetrical Ovarian Enlargement: Caught Timely Before the Cut!

J Pediatr Adolesc Gynecol. 2015 Jun;28(3):e83-5

Authors: Bhagwat NM, Dalwadi PP, Joshi AS, Pawal PS, Varthakavi PK

Abstract
BACKGROUND: Van Wyk-Grumbach syndrome is a rare complication of prolonged untreated primary hypothyroidism characterized by precocious puberty and enlarged multicystic ovaries. High index of suspicion and timely diagnosis can prevent unnecessary surgical procedures because this condition can be reversed with thyroid hormone supplementation.
CASE: A 12-year-old girl underwent abdominal ultrasonography for recurrent abdominal pain, which showed bilateral asymmetrical enlargement of ovaries. Ovarian tumor markers were negative. Subsequent evaluation revealed severe hypothyroidism. Patient was started on levothyroxine and both ovaries showed regression to normal volume within 1 year of normalizing thyroid function tests.
SUMMARY AND CONCLUSION: Prompt and adequate medical management with levothyroxine can completely reverse ovarian enlargement associated with hypothyroidism.

PMID: 25817767 [PubMed - indexed for MEDLINE]

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Surgical management outcomes and recurrence rate of orbital lymphangiomas.

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Surgical management, outcomes, and recurrence rate of orbital lymphangiomas.

J Clin Neurosci. 2015 May;22(5):877-82

Authors: Russin JJ, Rangel-Castilla L, Kalani MY, Spetzler RF

Abstract
Orbital lymphangiomas are rare benign vascular lesions of the orbit. Due to their intimate relationship to the orbital contents, gross total resection can be difficult, resulting in a relatively high recurrence rate. Between May 2002 and June 2013, eight patients (five male, three female) underwent surgical resection for orbital lymphangiomas at our institution. Of the seven patients with follow-up, six experienced improvement in presenting symptoms at a mean of 5.3 years (range 1-23 years). Recurrence was seen in five of the seven patients (71.4%). Recurrence developed at a mean of 7.2 years (range 1-23 years) after the initial procedure. New or worsening cranial nerve deficits were seen postoperatively in three of eight patients (37.5%) with follow-up. All postoperative deficits were resolved at last follow-up. Orbital lymphangiomas are challenging surgical lesions in which gross total resection is frequently not possible. Subtotal resection is safe and effective for symptomatic relief.

PMID: 25796957 [PubMed - indexed for MEDLINE]

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Third ventricular schwannoma with hydrocephalus.

Related Articles

Third ventricular schwannoma with hydrocephalus.

J Clin Neurosci. 2015 May;22(5):919-21

Authors: Li M, Kong J, Sun J, Li X

Abstract
Intraventricular schwannomas are rare, with only 20 cases reported in the literature to our knowledge, including two cases of schwannomas in the third ventricle. We report a 23-year-old man with a mass in the posterior portion of the third ventricle and obstructive hydrocephalus. The intraventricular mass was clearly visualized and removed by neuroendoscopic surgery, and endoscopic third ventriculostomy was simultaneously performed for the hydrocephalus. Histological and immunohistochemical assays of the surgical sample established a diagnosis of intraventricular schwannoma. The patient had a favourable outcome and no neurological deficits 1 year later. The schwannoma was distant from the choroid plexus, which supports the hypothesis that the schwannoma originated from ectopic neural crest cells that were displaced during embryogenesis.

PMID: 25796955 [PubMed - indexed for MEDLINE]

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Progressive post traumatic tearing of an arachnoid cyst membrane resulting in intracystic and subdural haemorrhage.

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Progressive post traumatic tearing of an arachnoid cyst membrane resulting in intracystic and subdural haemorrhage.

J Clin Neurosci. 2015 May;22(5):897-9

Authors: Pascoe HM, Phal PM, King JA

Abstract
We report the case of a 43-year-old man with a middle cranial fossa arachnoid cyst who presented post trauma with neurological symptoms. The initial CT scan of the brain did not detect acute changes in the arachnoid cyst but subsequent imaging revealed abnormalities which progressed over time. Arachnoid cysts are usually a benign and incidental finding. Rare complications such as intracystic haemorrhage and subdural haemorrhage can occur. It is important to be aware of these complications so that patients with arachnoid cysts are appropriately investigated when presenting with neurological symptoms.

PMID: 25769260 [PubMed - indexed for MEDLINE]

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Lambert-Eaton myasthenic syndrome associated to Merkel cell carcinoma: report of a case.

Related Articles

Lambert-Eaton myasthenic syndrome associated to Merkel cell carcinoma: report of a case.

Neurol Sci. 2015 Aug;36(8):1491-2

Authors: Bombelli F, Lispi L, Calabrò F, Corsi FM, Petrucci A

PMID: 25698125 [PubMed - indexed for MEDLINE]

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Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected].

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Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected].

J Neurooncol. 2015 Aug;124(1):65-74

Authors: Preuss M, Christiansen H, Merkenschlager A, Hirsch FW, Kiess W, Müller W, Kästner S, Henssler A, Pekrun A, Hauch H, Nathrath M, Meixensberger J, Pietsch T, Kuchelmeister K

Abstract
Pediatric tumors of the central nervous system composed of oligoid tumor cells showing diffuse leptomeningeal spread without a primary mass lesion seem to represent a novel tumor entity. The terms "diffuse leptomeningeal glioneural tumor" or-preferably-"disseminated oligodendroglial-like leptomeningeal tumor of childhood" (DOGLT) were proposed. Four patients were identified with clinico-neuropathologic findings compatible with DOGLT and a mean follow-up time of 54 months was determined. Seven different biopsies obtained from the four patients were histologically evaluated. Clinical course, diagnostic measures, histopathologic and radiologic features and treatment suggestions were recorded, on the basis of which diagnostic and therapeutic algorithm was proposed. Patients with DOGLT presented with hydrocephalus as first symptom, requiring neurosurgical therapy. Open arachnoid biopsy was necessary to confirm diagnosis. The oligoid cells in a desmoplastic or focally myxoid matrix showed OLIG2-, MAP2-, S-100 and rare HuC/HuD protein-immunopositivity. IDH1 (R132H)- and CD99-immunohistochemistry was negative in all patients. None of the evaluable biopsies of three patients showed chromosome 1p/19q deletion, neither as isolated nor combined allelic loss. Chemotherapy according to the SIOP-LGG 2004 standard induction and consolidation protocol resulted in complete response and partial response, respectively, in 50 % of the patients. However, after discontinuation of chemotherapy, two patients experienced tumor progression and one of them succumbed to the disease after 19 months. Radiological criteria as well as preliminary treatment results are presented after observation of four clinical cases. Prognosis and long-term clinical courses remain to be observed.

PMID: 25672644 [PubMed - indexed for MEDLINE]

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Radiofrequency ablation for benign thyroid nodules

Abstract

Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occurrence that has never been addressed in detail in the literature.

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Exophthalmos (Graves orbitopathy) in an ancient sculpture

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Predictors of Processing-Based Task Performance in Bilingual and Monolingual Children

Publication date: Available online 20 April 2016
Source:Journal of Communication Disorders
Author(s): Milijana Buac, Megan Gross, Margarita Kaushanskaya
In the present study we examined performance of bilingual Spanish-English-speaking and monolingual English-speaking school-age children on a range of processing-based measures within the framework of Baddeley's working memory model. The processing-based measures included measures of short-term memory, measures of working memory, and a novel word-learning task. Results revealed that monolinguals outperformed bilinguals on the short-term memory tasks but not the working memory and novel word-learning tasks. Further, children's vocabulary skills and socioeconomic status (SES) were more predictive of processing-based task performance in the bilingual group than the monolingual group. Together, these findings indicate that processing-based tasks that engage verbal working memory rather than short-term memory may be better-suited for diagnostic purposes with bilingual children. However, even verbal working memory measures are sensitive to bilingual children's language-specific knowledge and demographic characteristics, and therefore may have limited clinical utility.



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Managing Procedural Anxiety in Children

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Case 12-2016: An 8-Year-Old Boy with an Enlarging Mass in the Right Breast

Presentation of Case. Dr. Charumathi Baskaran (Pediatrics): An 8-year-old boy was seen in an outpatient clinic of this hospital because of an enlarging mass in the right breast. One week before this presentation, the patient was seen by a pediatrician at another medical facility for a routine…

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Resolution of Lumbar Disk Herniation without Surgery

Figure 1.

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Readmissions Observation and the Hospital Readmissions Reduction Program

Hospital readmissions within 30 days after discharge have drawn national policy attention because they are very costly, accounting for more than $17 billion in avoidable Medicare expenditures, and are associated with poor outcomes. In response to these concerns, the Affordable Care Act (ACA), which…

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Esophagogastric Bypass in Motion

Figure 1.

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Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion

Abstract

Background

Recurrent glioblastoma is associated with a poor overall survival. Antiangiogenic therapy results in a high tumor response rate but has limited impact on survival. Immunotherapy has emerged as an efficient treatment modality for some cancers, and preclinical evidence indicates that anti-VEGF(R) therapy can counterbalance the immunosuppressive tumor microenvironment.

Methods

We collected peripheral blood mononuclear cells (PBMC) of patients with recurrent glioblastoma treated in a randomized phase II clinical trial comparing the effect of axitinib with axitinib plus lomustine and analyzed the immunophenotype of PBMC, the production of cytokines and expression of inhibitory molecules by circulating T cells.

Results

PBMC of 18 patients were collected at baseline and at 6 weeks after initiation of study treatment. Axitinib increased the number of naïve CD8⁺ T cells and central memory CD4⁺ and CD8⁺ T cells and reduced the TIM3 expression on CD4⁺ and CD8⁺ T cells. Patients diagnosed with progressive disease on axitinib had a significantly increased number of regulatory T cells and an increased level of PD-1 expression on CD4⁺ and CD8⁺ T cells. In addition, reduced numbers of cytokine-producing T cells were found in progressive patients as compared to patients responding to treatment.

Conclusion

Our results suggest that axitinib treatment in patients with recurrent glioblastoma has a favorable impact on immune function. At the time of acquired resistance to axitinib, we documented further enhancement of a preexisting immunosuppression. Further investigations on the role of axitinib as potential combination partner with immunotherapy are necessary.

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The Value of Urgent Specialized Care for TIA and Minor Stroke

Patients with minor stroke or transient ischemic attack (TIA), characterized as a brief episode of neurologic dysfunction caused by focal cerebral ischemia without infarction, have the least amount of disability and the most to lose should they have a stroke. Patients with vanishing symptoms may…

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One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. Since then, there have been major changes in the management of TIA, including urgent…

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Resolution of Lumbar Disk Herniation without Surgery

Figure 1.

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Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20-Month-Old Male: Case Report and Review of the Literature

Factor X deficiency (FXD) is a rare bleeding disorder, which can result in severe bleeding symptoms such as intracranial hemorrhage (ICH). The most common bleeding symptoms are epistaxis and gum bleeding. ICH is reported in 9–26% of all patients with FXD, mostly during the first month of life. Here, we present a rare case of a male presenting with ICH at the age of 20 months as the first manifestation of FXD. Secondary prophylaxis with factor X substitution once weekly prevented further bleeding.

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Winter diet and food selection of the Black-necked Crane Grus nigricollis in Dashanbao Yunnan China

The Black-necked Crane Grus nigricollis is a globally vulnerable species whose food is the factor determining its long-term survival. Understanding dietary habits, food preferences, and related factors will facilitate the development of effective conservation plans for the protection of this vulnerable species. For this purpose, we used video recordings and sampling of food availability to examine the dietary composition and temporal variation in food selection of Black-necked Cranes wintering in the Dashanbao National Nature Reserve, China. The Black-necked Crane's diet consists primarily of domestic food crops such as grains (74%) and potatoes (8%), in addition to invertebrates (14%). A much smaller proportion of the diet was comprised of turnips and wild herbaceous plants and tubers. There was monthly variation in food selection, partially related to food availability. Grains were most available in November and decreased through the winter, whereas invertebrates were more available in November and February than in December and January. Grain consumption was lowest in November but higher from December through February. Invertebrate consumption was highest in November and February. The cranes preferred to eat grains throughout winter months, while they mainly selected invertebrates in November and February. We suggested invertebrate populations sharply declined in December and January due to the low temperature. In addition, grain consumption was negatively associated with invertebrate availability. In November, when invertebrates were most abundant, and despite a concomitant peak in grain abundance, we suggested cranes exhibited a preference for invertebrates over grains. We recommend that the protection administration provide appropriate supplemental foods for cranes during freezing weather.

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Growth and physiological responses of submerged plant Vallisneria natans to water column ammonia nitrogen and sediment copper

Background. The decline of submerged plant populations due to high heavy metal (e.g., Cu) levels in sediments and ammonia nitrogen (ammonia-N) accumulation in the freshwater column has become a significant global problem. Previous studies have evaluated the effect of ammonia-N on submerged macrophytes, but few have focused on the influence of sediment Cu on submerged macrophytes and their combined effects. Methods. In this paper, we selected three levels of ammonia-N (0, 3, and 6 mg L−1) and sediment Cu (25.75 ± 6.02 as the control, 125.75 ± 6.02, and 225.75 ± 6.02 mg kg−1), to investigate the influence of sediment Cu and ammonia-N on submerged Vallisneria natans. We measured the relative growth rate (RGR), above- and below- ground biomass, chlorophyll, non-protein thiol (NP-SH), and free proline. Results and Discussion. The below-ground biomass of V. natans decreased with increasing Cu sediment levels, suggesting that excessive sediment Cu can result in significant damage to the root of V. natans. Similarly, the above-ground biomass significantly decreased with increasing ammonia-N concentrations, indicating that excessive water ammonia-N can cause significant toxicity to the leaf of V. natans. In addition, high ammonia-N levels place a greater stress on submerged plants than sediment Cu, which is indicated by the decline of RGR and chlorophyll, and the increase of (NP-SH) and free proline. Furthermore, high sediment Cu causes ammonia-N to impose greater injury on submerged plants, and higher sediment Cu levels ( $\mathrm{Cu}\geq 125.75$ Cu ≥ 125 . 75 mg kg−1) led to the tolerant values of ammonia-N for V. natans decreasing from 6 to 3 mg L−1. This study suggests that high sediment Cu restricts the growth of plants and intensifies ammonia-N damage to V. natans.

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MAP2 splicing is altered in Huntington's disease

Abstract

Dendritic alteration of striatal medium spiny neurons is one of the earliest morphological abnormalities in Huntington's disease (HD). The main microtubule-associated protein in dendrites is MAP2. The low-molecular weight isoforms of MAP2 (LMW-MAP2) are the juvenile forms resulting from exclusion of the sequence encoded by exons E7-E9 and are downregulated after the early stages of neuronal development when E7-E9 exon-including high-molecular weight isoforms (HMW-MAP2) are favored. Splicing alteration has recently been proposed to contribute to HD in view of two pathogenic missplicing events resulting in a highly toxic N-terminal version of mutant huntingtin and in a detrimental imbalance in MAP Tau isoforms with 3 or 4 tubulin-binding repeats. Both splicing events are postulated targets of the SR splicing factor SRSF6 which has recently been reported to be dramatically altered in HD. SR proteins often regulate functionally related sets of genes and SRSF6 targets are enriched in genes involved in brain organogenesis including several actin-and tubulin-binding proteins. Here we hypothesized that MAP2 might be target of SRSF6 and altered in HD. By SRSF6 knockdown in neuroblastoma cells we demonstrate that splicing of MAP2 E7-E9 exons is affected by SRSF6. We then show a disbalance in LMW and HMW MAP2 mRNA isoforms in HD striatum in favor of the juvenile LMW forms together with a decrease in total MAP2 mRNA. This is accompanied by a global decrease in total MAP2 protein due to almost total disappearance of HMW-MAP2 isoforms with preservation of LMW-MAP2 isoforms. Accordingly, the predominant dendritic MAP2 staining in striatal neuropil of control subjects is absent in HD cases. In these, MAP2-immunoreactivity is faint and restricted to neuronal cell bodies often showing a sharp boundary at the base of dendrites. Together, our results highlight the importance of splicing alteration in HD and suggest that MAP2 alteration contributes to dendritic atrophy. This article is protected by copyright. All rights reserved.

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Society Information

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Table of Contents

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Preprints

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Rod-shaped and Fluorine-substituted Hydroxyapatite Free of Molecular Immunopotentiator Stimulates Anti-cancer Immunity in vivo

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC02848A, Communication

Xiupeng Wang, Xia Li, Atsuo Ito, Yohei Watanabe, Noriko M. Tsuji
Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized by a facile hydrothermal method. The rod-shaped FHA significantly increased cellular uptake of a model antigen by bone marrow dentritic cells...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Proposed radiological criteria for pre-operative determination of resectability in peritoneal-based malignancies

Abstract

Background

The selection of patients for cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy infusion (HIPEC) is important, and relies heavily on imaging. However, it has been reported that Computer Tomographic (CT) scans may only achieve a low sensitivity of 33% for peritoneal disease. We propose a set of radiological criteria for pre-operative determination of resectability of peritoneal disease in peritoneal-based malignancies and validate this in our cohort of patients.

Methods

A retrospective review of all patients who underwent laparotomy with a view for CRS and HIPEC, at the National Cancer Centre Singapore from January 2000 to April 2010, was performed. Intra-operative Peritoneal Cancer Index (PCI) scores were recorded. The pre-operative imaging was reviewed with a senior radiologist who was blinded, and recorded the radiological PCI scores (CT-PCI) and eight additional CT prognostic factors (CT-PF). The CT-PCI and CT-PF scores were then compared with the intra-operative findings to determine the radiological accuracy. The scores and the individual prognostic factors were then evaluated for their predictive ability for unresectability.

Results

Comparison of the CT-PCI and PCI scores showed a concordance correlation coefficient at 0.52 (95% CI 0.34–0.7). Accuracy was increased with the addition CT-PF. The presence of omental caking and ascites were predictors of unresectability. We propose a scoring system which is able to predict for unresectable disease with a specificity of 80% and a sensitivity of 62%.

Conclusion

With our proposed criteria, and scoring system, the selection of patients for CRS and HIPEC can be improved, and unnecessary exploratory operations avoided.

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One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. Since then, there have been major changes in the management of TIA, including urgent…

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Resolution of Lumbar Disk Herniation without Surgery

Figure 1.

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The Value of Urgent Specialized Care for TIA and Minor Stroke

Patients with minor stroke or transient ischemic attack (TIA), characterized as a brief episode of neurologic dysfunction caused by focal cerebral ischemia without infarction, have the least amount of disability and the most to lose should they have a stroke. Patients with vanishing symptoms may…

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PKD_Not always nomina sunt consequentia rerum

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PiB and other amyloid-PET tracers for the study of white matter and multiple sclerosis

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Benzothiazole and stilbene derivatives as promising PET myelin radiotracers for multiple sclerosis

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PKD or not PKD - that is the question

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Incidence clinical presentation and mortality of liver cirrhosis in Southern Sweden: a 10-year population-based study

Alimentary Pharmacology and Therapeutics

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Five-year results of oral antiviral therapy in HBeAg-negative chronic Hepatitis B

The Turkish Journal of Gastroenterology

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Cholangiocytes derived from induced pluripotent stem cells for disease modeling

Current Opinion in Gastroenterology

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Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation

Cancer

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Increased risk of advanced colorectal neoplasia among Korean men with metabolic abnormality and obesity

Clinical Gastroenterology and Hepatology

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Genomic alterations observed in colitis-associated cancers are distinct from those found in sporadic colorectal cancers and vary by type of inflammatory bowel disease

Gastroenterology

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h-Prune is associated with poor prognosis and epithelial-mesenchymal transition in patients with colorectal liver metastases

International Journal of Cancer

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Randomized trial of 1-week vs. 2-week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding

Hepatology

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Treatment of chronic hepatitis C in patients with cirrhosis

Current Opinion in Gastroenterology

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Management of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: Recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5)

The Lancet Infectious Diseases

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Evaluation of scoring models for identifying the need for therapeutic intervention for upper gastrointestinal bleeding: a new prediction score model for Japanese patients

Digestive Endoscopy

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A retrospective study on the role of diabetes and metformin in colorectal cancer disease survival

Current Oncology

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