Αρχειοθήκη ιστολογίου

Κυριακή 18 Νοεμβρίου 2018

Cover Image

Clinical Otolaryngology Cover Image

The cover image is based on the Correspondence Video head impulse test results suggest that different pathomechanisms underlie sudden sensorineural hearing loss with vertigo and vestibular neuritis: Our experience in fi fty‐two patients by Qingxiu Yao et al., https://doi.org/10.1111/coa.13196.




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Author Guidelines



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Acknowledgements to Reviewers



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Issue Information



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Can Thyroid Screening During Pregnancy Protect Your Baby?

From: Healthline Media
Health News
Can Thyroid Screening During Pregnancy Protect Your Baby?
Experts have been debating the benefits of universal thyroid testing in pregnant women.

 

 

The post Can Thyroid Screening During Pregnancy Protect Your Baby? appeared first on American Thyroid Association.



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Three novel mutations of the ATP2A2 gene in Chinese patients with Darier disease



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Occipital Hairline: A forgotten area

Summary

Hair restoration surgery is one of the fascinating fields of modern day cosmetic surgery. A good hair transplant is characterized by a naturalness in terms of strategic distribution of hair. A very important point which is very rarely taken care is the "posterior or occipital" hairline. It is formed by the posterior 1 cm of hair which are placed on the vertex or crown and constitute the part which is normally hidden by the long hair. Many surgeons while creating the slits in the recipient area forget this equally important point. And make the slits in the lines. As the care is taken while creating the slits in the anterior hairline, the same enthusiasm is required throughout the procedure especially the posterior part of the recipient area. The slits in the posterior hairline should also be created in a wavy, irregularly irregular fashion. The posterior hairline forms an important part of a hair restoration surgery. It contributes remarkably toward the overall naturalness of the results. A carefully executed posterior hairline reduces the chances of detection by the general public



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Future Trends in Demand for Liver Transplant: Birth-Cohort Effects among Patients with NASH and HCC

Background With increasing U.S. adiposity, NASH is now a leading liver transplant (LT) indication. Given its association with hepatocellular carcinoma (HCC), the burden of NASH is substantial. We analyzed birth-cohort effects among NASH LT registrants, with and without HCC. Methods All new LT registrants in UNOS (1995-2015) were identified. Birth-cohorts were: 1936-1940, 1941-1945, 1946-1950, 1951-1955, 1956-1960, 1961-1965, 1966-1970, 1971-2015. Poisson regression examined trends in LT registration, by disease etiology (NASH, HCV, OTHER), and HCC. Results We identified 182,368 LT registrants with median age 52 years (range 0-86). Nine-percent (n=16,160) had NASH, 38% (n=69,004) HCV, 53% (n=97,204) OTHER. HCC was present in: 13% (n=2,181), 27% (n=18,295), and 11% (n=10,902), of NASH, HCV, and OTHER, respectively. LT registration for HCC increased significantly from 2002-2015 across all etiologies (NASH 6%➔18%; HCV 19%➔51%; OTHER 9%➔16%, p

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Societal and Professional Obligation in the Care of the Living Organ Donor

No abstract available

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mTOR Inhibitor Everolimus in Regulatory T cell Expansion for Clinical Application in Transplantation

Background Experimental and pre-clinical evidence suggest that adoptive transfer of regulatory T cells (Tregs) could be an appropriate therapeutic strategy to induce tolerance and improve graft survival in transplanted patients. The University of Kentucky Transplant Service Line is developing a novel Phase I/II clinical trial with ex vivo expanded autologous Tregs as an adoptive cellular therapy in renal transplant recipients who are using everolimus (EVR)-based immunosuppressive regimen. Methods The aim of this study was to determine the mechanisms of action and efficacy of EVR for the development of functionally competent Treg cell-based adoptive immunotherapy in transplantation to integrate a common EVR-based regimen in vivo (in the patient) and ex vivo (in the expansion of autologous Treg cells). CD25+ Treg cells were selected from leukapheresis product with a GMP-compliant cell separation system and placed in 5-day (short) or 21-day (long) culture with EVR or rapamycin (RAPA). Multi-parametric flow cytometry analyses were used to monitor the expansion rates, phenotype, autophagic flux and suppressor function of the cells. PI3K/AKT/mTOR signaling pathway profiles of treated cells were analyzed by western blot and cell bioenergetic parameters by extracellular flux analysis. Results EVR-treated cells showed temporary slower growth, lower metabolic rates, and reduced phosphorylation of AKT compared to RAPA-treated cells. In spite of these differences, the expansion rates, phenotype, and suppressor function of long-term Treg cells in culture with EVR were similar to those with RAPA. Conclusions Our results support the feasibility of EVR to expand functionally competent Treg cells for their clinical use. *Both authors contributed equally to this manuscript #Corresponding Authors: Roberto Gedaly, MD and Francesc Marti, PhD, University of Kentucky Transplant Center, 740 South Limestone, K301, Lexington, KY, 40536-0284, USA, Email: rgeda2@uky.edu & fmart3@uky.edu. Tel: 1-859-323-4661, FAX: 1-859-257-3644 Clinical Trial Notation: National Cancer Trial Registry; # NCT03284242 Authorship: Designed research: RG and FM Collected data: FDS, LT, GH, MIM, MCA, HCM and FM Contributed analytic tools: MH, DAB, JH, CDJ Analyzed data: RG, AAT and FM Wrote the manuscript: RG and FM Critical editing of content: all authors Approval of final version: all authors Disclosure: The authors declare no commercial or financial conflicts of interest Funding sources: This research was supported by the National Institute of Allergy and Infectious Diseases (NIAID) NIH grant R03-AI135592 to FM, and by the National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH grant UL1TR001998 to RG and FM. The Redox Metabolism Shared Resource (RMSR) and the University of Kentucky Flow Cytometry and Immune Monitoring (FCIM) core facilities received support from the National Cancer Institute (NCI) NIH Cancer Center Support Grant P30CA177558 awarded to the University of Kentucky Markey Cancer Center. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Reevaluation of the Kidney Donor Risk Index (KDRI)

Background The Kidney Donor Risk Index (KDRI) is a score applicable to deceased kidney donors which reflects relative graft failure risk associated with deceased donor characteristics. The KDRI is widely used in kidney transplant outcomes research. Moreover, an abbreviated version of KDRI is the basis, for allocation purposes, of the "top 20%" designation for deceased donor kidneys. Data upon which the KDRI model was based used kidney transplants performed between 1995 and 2005. Our purpose in this report was to evaluate the need to update the coefficients in the KDRI formula, with the objective of either (a) proposing new coefficients or (b) endorsing continued used of the existing formula. Methods Using data obtained from the Scientific Registry of Transplant Recipients (SRTR), we analyzed n=156,069 deceased donor adult kidney transplants occurring from 2000 to 2016. Cox regression was used to model the risk of graft failure. We then tested for differences between the original and updated regression coefficients, and compared the performance of the original and updated KDRI formulas with respect to discrimination and predictive accuracy. Results In testing for equality between the original and updated KDRIs, few coefficients were significantly different. Moreover, the original and updated KDRI yielded very similar risk discrimination and predictive accuracy. Conclusions Overall, our results indicate that the original KDRI is robust and is not meaningfully improved by an update derived through modeling analogous to that originally employed. *Corresponding author: Douglas Schaubel, University of Michigan, 1415 Washington Hts., Ann Arbor, MI, 48109-2029; email: deschau@umich.edu Author Contributions: Yingchao Zhong: research design; literature review; database management; data analysis; writing manuscript; statistical computing. Douglas Schaubel: research design; database management; data analysis; writing manuscript. Jack Kalbfleisch: research design; data analysis; writing manuscript. Valarie Ashby: research design; literature review; data analysis; writing manuscript. Pandu Rao: research design; literature review; writing manuscript. Randall Sung: research design; literature review; writing manuscript. Disclosure: The authors have no conflicts of interest to disclose. Funding: This work was supported in part by National Institutes of Health Grant R01 DK070869, and by a Michigan Institute for Clinical and Health Research (MICHR). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Donor Urinary C5a Levels Independently Correlate With Posttransplant Delayed Graft Function

Background Accumulating evidence implicates the complement cascade as pathogenically contributing to ischemia-reperfusion injury and delayed graft function (DGF) in human kidney transplant recipients. Building upon observations that kidney injury can initiate in the donor before nephrectomy, we tested the hypothesis that anaphylatoxins C3a and C5a in donor urine prior to transplantation associate with risk of post-transplant injury. Methods We evaluated the effects of C3a and C5a in donor urine on outcomes of 469 deceased donors and their corresponding 902 kidney recipients in a subset of a prospective cohort study. Results We found a 3-fold increase of urinary C5a concentrations in donors with stage 2 and 3 AKI compared donors without AKI (p

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Comment on “Race/Ethnicity and Sex Both Affect Opioid Administration in the Emergency Room”

No abstract available

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Systematic Review of the Efficacy and Safety of Gabapentin and Pregabalin for Pain in Children and Adolescents

The barriers to opioid use in some countries necessitate the need to identify suitable alternatives or adjuncts for pain relief. The gabapentinoids (gabapentin and pregabalin) are approved for the management of persistent pain in adults, but not in children. Searches were conducted in Embase, Medline, Scopus, and Web of Science up until November 2017, for randomized controlled trials that investigated the analgesic effects of gabapentin or pregabalin in children and adolescents

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Glycocalyx Degradation Is Independent of Vascular Barrier Permeability Increase in Nontraumatic Hemorrhagic Shock in Rats

BACKGROUND: Glycocalyx shedding after traumatic hemorrhagic or septic shock, as well as different resuscitation fluids, has been causally linked to increased vascular barrier permeability (VBP) resulting in tissue edema. In nontraumatic hemorrhagic shock (NTHS), it remains questionable whether glycocalyx degradation in itself results in an alteration of VBP. The composition of fluids can also have a modulatory effect on glycocalyx shedding and VBP. We hypothesized that the shedding of the glycocalyx during NTHS has little effect on VBP and that the composition of fluids can modulate these effects. METHODS: Fully instrumented Wistar-albino rats were subjected to a pressure-controlled NTHS (mean arterial pressure of 30 mm Hg) for 60 minutes. Animals were fluid resuscitated with Ringer's acetate, balanced hydroxyethyl starch (HES) solution, or 0.9% normal saline to a mean arterial pressure of 80 mm Hg and compared with shams or nonresuscitated NTHS. Glycocalyx shed products were determined at baseline and 60 minutes after fluid resuscitation. Skeletal muscle microcirculation was visualized using handheld vital microscopy. VBP changes were assessed using plasma decay of 3 fluorescent dyes (40- and 500-kDa dextran and 70-kDa albumin), Evans blue dye exclusion, intravital fluorescence microscopy, and determination of tissue edema (wet/dry weight ratio). RESULTS: All glycocalyx shedding products were upgraded as a result of NTHS. Syndecan-1 significantly increased in NTHS (mean difference, −1668; 95% confidence interval [CI], −2336 to −1001; P

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In Response

No abstract available

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Progressive Increase in Scholarly Productivity of New American Board of Anesthesiology Diplomates From 2006 to 2016: A Bibliometric Analysis

BACKGROUND: Improving research productivity is a common goal in academic anesthesiology. Initiatives to enhance scholarly productivity in anesthesiology were proposed more than a decade ago as a result of emphasis on clinical work. We hypothesized that American Board of Anesthesiology diplomates certified from 2006 to 2016 would be progressively more likely to have published at least once during this time period. METHODS: A complete list of 17,332 new diplomates was obtained from the American Board of Anesthesiology for the years 2006 to 2016. These names were queried using PubMed, and the number of publications up to and including the diplomate's year of primary certification was recorded. Descriptive statistics and logistic regression analysis were used to analyze the association of the year of primary certification and whether a diplomate had published at least once. RESULTS: The percentage of American Board of Anesthesiology diplomates with ≥1 publication at the time of primary certification increased from 14.9% to 29.3% from 2006 to 2016. The mean number of publications per diplomate more than doubled from 0.31 to 0.79. Logistic regression analysis revealed the year of primary certification as significantly associated with having ≥1 publication (P

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Essentials of Anesthesia for Infants and Neonates

No abstract available

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Intraluminal Pulmonary Vein Stenosis in Children: A “New” Lesion

Pulmonary vein stenosis (PVS) is a rare disorder that leads to progressive narrowing of the extrapulmonary veins. PVS has been reported in both children and adults and in its worse iteration leads to pulmonary hypertension, right ventricular failure, and death. Multiple etiologies of PVS have been described in children and adults. This review will focus on intraluminal PVS in children. Intraluminal PVS has an estimated incidence ranging from 0.0017% to 0.03%. It is associated with conditions such as prematurity, bronchopulmonary dysplasia, necrotizing enterocolitis, Smith-Lemli-Opitz syndrome, and Down syndrome. Cardiac catheterization and pulmonary vein angiography are the gold standard for diagnosis and anatomic delineation. Other imaging modalities including magnetic resonance imaging, chest tomography, and transesophageal echocardiography are increasingly being used. Mortality of PVS in children is approximately 50%. Predictors of mortality include involvement of ≥3 pulmonary veins, bilateral pulmonary vein involvement, onset of PVS in infancy, elevated pulmonary artery pressure or systolic pulmonary artery-to-aortic pressure ratio, right ventricular dysfunction, restenosis after surgery, distal/upstream disease, and disease progression to previously uninvolved pulmonary veins. Treatment includes catheter-based pulmonary vein dilations with or without stenting, surgical interventions, medical therapy, and in some instances, lung transplantation. Cardiac catheterization for PVS involves a comprehensive hemodynamic and anatomic assessment of the pulmonary veins as well as therapeutic transcatheter interventions. Several surgical strategies have been used. Sutureless repair is currently most commonly used, but patch venoplasty, endarterectomy, ostial resection, and reimplantation are used in select circumstances as well. Medical therapies such as imatinib mesylate and bevacizumab are increasingly being used in an effort to suppress the myofibroblastic proliferation seen in PVS patients. Lung transplantation has been used as an alternative treatment strategy for end-stage, refractory PVS. Nonetheless, despite the different innovative approaches used, morbidity and mortality remain high. At present, the preferred treatment strategy is frequent reassessment of disease progression to guide use of catheter-based and surgical interventions in conjunction with medical therapy. Accepted for publication October 8, 2018. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Viviane G. Nasr, MD, Department of Anesthesiology, Critical Care and Pain Medicine, Division of Cardiac Anesthesia, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115. Address e-mail to viviane.nasr@childrens.harvard.edu. © 2018 International Anesthesia Research Society

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What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

Publication date: Available online 17 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Katrina J. Allen, Jennifer J. Koplin



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The Atopic March and Atopic Multimorbidity: Many Trajectories, Many Pathways

Publication date: Available online 17 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Amy S. Paller, Jonathan M. Spergel, Paola Mina-Osorio, Alan D. Irvine

Abstract

The "atopic march" recognizes the increased occurrence of asthma and/or allergic rhinitis after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD onset are poorly understood, but may involve the impaired cutaneous barrier, which facilitates cutaneous sensitization. The association may also be driven or amplified in susceptible individuals by a systemic Th2-dominant immune response to cutaneous inflammation. However, these associations may merely involve shared genetic loci and environmental triggers, including microbiome dysregulation, with the temporal sequence reflecting tissue-specific peak time of occurrence of each disease, suggesting more of a clustering of disorders than a march. Prospective longitudinal cohort studies provide an opportunity to explore the relationships between post-dermatitis development of atopic disorders and potential predictive phenotypic, genotypic, and environmental factors. Recent investigations implicate disease severity and persistence, age of onset, parental atopic history, FLG (filaggrin) mutations, polysensitization, and the non-rural environment among risk factors for development of multiple atopic comorbidities in young children with AD. Early intervention studies to repair the epidermal barrier or alter exposure to the microbiome or allergens may elucidate the relative roles of barrier defects, genetic locus alterations, and environmental exposures in the risk and sequence of occurrence of Th2 activation disorders.



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The effect of neonatal maternal separation on short-chain fatty acids and airway inflammation in adult asthma mice

Publication date: Available online 17 November 2018

Source: Allergologia et Immunopathologia

Author(s): L. Qian, L. Lu, L. Huang, Q. Wen, J. Xie, W. Jin, H. Li, L. Jiang

Abstract
Background

To investigate neonatal maternal separation (NMS) effects on airway inflammation of asthma and potential mechanism using a mouse model.

Methods

80 Balb/c neonatal male mice were randomly assigned to NMS and non-NMS groups. Feces were collected on PND21, 28, 35 and 42 to analyze microbiota and short-chain fatty acids (SCFAs). Non-NMS group were then divided into control (group A) and asthma groups (group B), while NMS group was assigned to NMS + asthma (group C) and NMS + SCFAs + asthma groups (group D). Inflammatory cells and eosinophils (EOS) in bronchoalveolar lavage fluid (BALF) were assessed. Pathological changes and cytokines in lung tissue were observed. Protein expression of Occludin and E-cadherin in airway epithelial was examined.

Results

The number of S′, diversity index H′ and dominance index D′, as well as content butyric acid in NMS group C were significantly lower than non-NMS group B (p < 0.05). Mice in group C had a higher level of inflammatory cells and EOS compared with group A, B and D. EOS moderate infiltration was found in mice of group B, C and D. Mice in group C had significantly higher levels of cytokines and showed slightly increased bronchial epithelium goblet cells and a small amount of visceral secretions. Occludin and E-cadherin expression in lung in B, C and D groups was depressed, and protein level in group C was significantly lower than group B and D.

Conclusions

NMS is associated with exacerbated inflammation of adult asthma by changing intestinal microflora resulting in butanoic acid decline and airway epithelial barrier damage.



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IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus

Publication date: Available online 17 November 2018

Source: Archives of Oral Biology

Author(s): Hui Wang, Yuchen Jiang, Hongning Wang, Zhenhua Luo, Yuanyuan Wang, Xiaobing Guan

Abstract
Objective

The aim of the present study was to investigate the correlation between IL-25 expression and disease severity, and the potential immunoregulatory role of IL-25 expression in oral lichen planus (OLP).

Materials and Methods

The oral mucosal tissue samples obtained from OLP patients and healthy controls (HCs) were analyzed for IL-25 expression by real-time quantitative PCR (qPCR) and immunohistochemistry. Recombinant IL-25 was used to stimulate OLP patient-derived CD4 + T cells, and then IL-4 secretion and mRNA expression were evaluated by ELISA and qPCR, respectively. The efficiency of the siRNA-mediated knockdown of IL-25R expression in oral keratinocytes was determined by qPCR and Western blotting. Human oral keratinocyte cells were cultured with the recombinant human cytokines IL-25, IL-17 A and IL−17 F. The production of associated cytokines by keratinocytes was determined by qPCR. Statistical analyses of quantitative data were performed using SPSS software.

Results

The IL-25 and IL-4 mRNA levels were elevated and correlated significantly with each other in specific OLP subtype lesions compared to HCs, while the numbers of IL-25 positive cells were also increased in local OLP lesions as compared to HCs. In vitro culture with recombinant IL-25 could significantly promote CD4 + T cells from both subtypes of OLP to produce IL-4 mRNA and remarkably elevate supernatant IL-4 levels in reticular OLP CD4 + T cell cultures, which may be attributed to the elevated expression of IL-25R in local OLP lesions. Statistical analyses demonstrated that the simultaneously increased levels of IL-4, CXCL8 and CCL20 in keratinocytes were induced by IL-25 but not IL-17 A or IL−17 F. Decreasing IL-25R subunit expression by siRNA-mediated knockdown significantly blocked the expression of all cytokine-produced inflammatory mediators in oral keratinocytes.

Conclusions

In OLP lesions, IL-25 can function to mediate the Th2 response in specific disease subtypes, which may be an important cause of OLP disease chronicity and persistent inflammation.



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A Rare Case of Monophasic Synovial Sarcoma of Thoracic Vertebra

Synovial sarcoma of spine is an extremely rare malignancy with poor prognosis. It is often metastatic at the time of presentation. Its relative rarity and histological resemblance to other tumors make it diagnostically challenging, requiring the need of immunohistochemistry and cytogenetics for definite diagnosis. Surgery is the mainstay of therapy with adjunct chemotherapy, although survival rates are very low.

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The Use of Point-of-Care Ultrasonography in Trauma Anesthesia

Publication date: Available online 17 November 2018

Source: Anesthesiology Clinics

Author(s): Davinder Ramsingh, Venkat Reddy Mangunta



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Intervertebral Vacuum Phenomenon: A Cause of Bulging of the Pharyngeal Wall

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Luis Gorospe, Rosa María Gómez-García, Juan Martínez San Millán



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Low Grade Mucoepidermoid Carcinoma of a Minor Salivary Gland of the Tongue in a Paediatric Patient

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): María Fernanda Vargas Gamarra, José María Perolada Vilmaña, Miguel Armengot Carceller



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Practice Guidelines for the Diagnosis and Management of Benign Paroxysmal Positional Vertigo Otoneurology Committee of Spanish Otorhinolaryngology and Head and Neck Surgery Consensus Document

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Paz Pérez-Vázquez, Virginia Franco-Gutiérrez, Andrés Soto-Varela, Juan Carlos Amor-Dorado, Eduardo Martín-Sanz, Manuel Oliva-Domínguez, Jose A. Lopez-Escamez

Abstract

Benign paroxysmal positional vertigo is the most frequent episodic vestibular disorder. The purpose of this guide, requested by the committee on otoneurology of the Spanish Society of Otolaryngology and Head and Neck Surgery, is to supply a consensus document providing practical guidance for the management of BPPV. It is based on the Barany Society criteria for the diagnosis of BPPV. This guideline provides recommendations on each variant of BPPV, with a description of the different diagnostic tests and the therapeutic manoeuvres. For this purpose, we have selected the tests and manoeuvres supported by evidence-based studies or extensive series. Finally, we have also included a chapter on differential diagnosis and a section relating to general aspects in the management of BPPV.

Resumen

El vértigo posicional paroxístico benigno (VPPB) es la causa más frecuente de vértigo vestibular episódico. EL propósito de esta guía, encomendada por la Comisión de Otoneurología de la SEORL CCC, es disponer de un documento de consenso que sirva de guía práctica para el manejo del VPPB en la clínica diaria. El punto de partida es la clasificación elaborada por la Barany Society, con sus variantes clínicas. Incluye una descripción de las pruebas diagnósticas y de las maniobras terapéuticas para cada una de las variantes establecidas, habiéndose seleccionado aquellas con estudios con nivel adecuado de evidencia o con suficientes series de soporte. Se ha incluido también un capítulo de diagnóstico diferencial, así como un apartado de aspectos generales básicos en el manejo de los pacientes con VPPB.



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Salvage Surgery in the Treatment of Local Recurrences of Nasopharyngeal Carcinomas

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): María Cecilia Salom, Fernando López, Esteban Pacheco, Gabriela Muñoz, Patricia García-Cabo, Laura Fernández, Vanessa Suárez, José Luis Llorente

Abstract
Introduction and Objectives

Chemoradiotherapy is the treatment of choice for nasopharyngeal carcinoma. Local recurrences are one of the leading causes of death in these patients, and surgical salvage the treatment of choice. Our goal was to evaluate and compare the results of salvage surgery in the treatment of local recurrence of nasopharyngeal carcinomas comparing endoscopic to open approaches.

Methods

Twenty patients with local recurrence of nasopharyngeal carcinomas underwent surgery: 12 patients underwent open surgery and 8 endoscopic endonasal transpterygoid nasopharyngectomy. One patient was classified as rT1, three as rT2, two as rT3, and six as rT4 in the group of open approaches; in the endoscopic series, two patients were rT1, five rT2 and one rT3.

Results

In 3 patients (25%) operated by an open approach (one rT4, one rT3 and one rT2) a complete gross resection was not achieved. Gross total resection was achieved in patients operated by endoscopic surgery. The complication rate in the group operated by an open approach was 92% (five minor complications, five moderate complications, and one serious complication) and in the group that underwent endoscopic surgery all patients had some complication (seven had minor complications and one patient developed a severe complication). Survival at 3 and 5 years was 53% and 42% with the open approach and 100% and 50% with the endoscopic approach, respectively.

Conclusions

Endoscopic approaches decrease the morbidity associated with open approaches and allow for favourable oncological control.

Resumen
Introducción y Objetivos

La quimiorradioterapia es el tratamiento de elección del carcinoma de nasofaringe. Las recurrencias locales son una de las principales causas de mortalidad en estos pacientes: el rescate quirúrgico o la reirradiación son el tratamiento de elección, según la disponibilidad. El objetivo fue evaluar y comparar los resultados de la cirugía de rescate en el tratamiento de las recidivas locales de los carcinomas nasofaríngeos mediante abordajes abiertos vs. endoscópicos.

Métodos

Veinte pacientes con recidivas locales de carcinomas nasofaríngeos fueron intervenidos quirúrgicamente: 12 pacientes fueron intervenidos mediante cirugía abierta y 8 mediante un abordaje endoscópico endonasal transpterigoideo. Un paciente fue estadiado como rT1; 3 como rT2; 2 como rT3 y 6 como rT4 en el grupo de abordajes abiertos; en la serie endoscópica, 2 pacientes fueron rT1, 5 fueron rT2 y uno fue rT3.

Resultados

En 3 de los pacientes (25%) intervenidos mediante cirugía abierta (un rT4, un rT3 y un rT2) no se logró una resección macroscópica completa). En el grupo endoscópico la resección fue completa en todos los pacientes. La tasa de complicaciones en el grupo intervenido mediante abordajes abiertos fue del 92% (5 complicaciones leves, 5 complicaciones moderadas y una complicación grave) y en el grupo intervenido mediante endoscopia fue del 100% (7 sufrieron complicaciones leves y un paciente una complicación grave). La supervivencia a los 3 y 5 años fue del 53 y del 42% en el abordaje abierto y del 100 y del 75% en el abordaje endoscópico, respectivamente.

Conclusiones

Los abordajes endoscópicos disminuyen la morbilidad asociada a los abordajes abiertos y permiten obtener un control oncológico favorable.



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Epidemiology of epistaxis in the emergency department of a southern European tertiary care hospital

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Luis Roque Reis, Filipe Correia, Luis Castelhano, Pedro Escada

Abstract
Objective

Epistaxis is the most common rhinological emergency seen in the emergency department. The purpose of this study was to evaluate epidemiological data of epistaxis in a southern European tertiary care hospital.

Methods

A retrospective study was conducted during the period between January 2009 and December 2015. We analyzed the distribution by cross-referencing the demographic variables, destination after medical discharge, inpatient characteristics (major comorbid diseases, medication, bleeding localization and treatment) and health-care costs with the disease.

Results

Epistaxis accounted for approximately 1 in 30 visits to the ED and 77 out of a population of 100,000 was served by that ED. Overall, 71,624 patients were treated and 2371 patients presented with epistaxis (3.31%). One-thousand three-hundred and twenty-seven cases were male and 1044 female (p <.001). The mean age was 56 years (±26). Age distribution was bimodal, with peaks among those <10 years and >70 (p <.001). Epistaxis was more common in the winter months (p < 0.001). The main referral destinations (6.8%) included outpatient (2.9%) and inpatient (1.9%) services. Hospitalization was more frequent between the ages of 60 and 80 years (p =.029), and the major comorbidity was hypertension (47.8%). Medication interfering with haemostasis was documented in 30.4%. Most inpatient epistaxis was managed in a non-interventional manner and only. 5% of patients needed surgery. The mean total health-care cost was 69.8 € per episode.

Conclusion

Emergency epistaxis was more frequent in men, the elderly, patients with underlying comorbidities, during the winter months, and showed a higher risk of referral and hospitalization with increasing age (as a result of an aging population in western countries). The main hospital expenses for epistaxis are related to hospitalization and health care costs.

Resumen
Objetivo

La epistaxis es la urgencia rinológica más comúnmente observada en el servicio de urgencias (SU). El objetivo de este estudio es evaluar los datos epidemiológicos de la epistaxis en un hospital de atención terciaria del sur de Europa.

Mèc)todos

Se realizó un estudio retrospectivo durante el periodo comprendido entre enero de 2009 y diciembre de 2015. Analizamos la distribución entrecruzando las variables demográficas, el destino tras el alta mèc)dica, las características hospitalarias (enfermedades comórbidas mayores, medicación, localización del sangrado y tratamiento) y los costes sanitarios con la enfermedad.

Resultados

La presentación con epistaxis supuso aproximadamente una de 30 visitas al SU, donde se atendió a una población de 77 de cada 100.000 habitantes. En general se trataron 71.624 pacientes, de los cuales 2.371 se presentaron con epistaxis (3,31%). Mil trescientos veintisiete casos eran varones y 1.044 mujeres (p < 0,001). La edad media fue de 56 años (± 26). La distribución de la edad fue bimodal, con valores máximos entre ellos < 10 años y > 70 (p < 0,001). La epistaxis fue más común durante los meses invernales (p < 0,001). Los principales destinos de derivación (6,8%) incluyeron los servicios ambulatorios (2,9%) y hospitalarios (1,9%). Las hospitalizaciones fueron más frecuentes entre los 60 y 80 años (p = 0,029), siendo la hipertensión la mayor comorbilidad (47,8%). La medicación que interfirió con la hemostasia se documentó en el 30,4%. A la mayoría de pacientes hospitalarios con epistaxis se les trató de manera no intervencionista, y únicamente el 0,5% de los casos precisó cirugía. Los costes sanitarios totales medios fueron del 69,8 € por episodio.

Conclusión

La epistaxis de urgencia fue más frecuente en varones, personas mayores, pacientes con comorbilidades subyacentes, durante los meses invernales, y reflejó un mayor riesgo de derivación y hospitalización con el incremento de la edad (como resultado del envejecimiento de la población en los países occidentales). Los principales gastos hospitalarios en los casos de epistaxis guardan relación con la hospitalización y los costes de la atención sanitaria.



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Multiple Sclerosis: Left Advantage for Auditory Laterality in Dichotic Tests of Central Auditory Processing and Relationship of Psychoacoustic Tests With the Multiple Sclerosis Disability Scale-EDSS

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Yolanda Rebeca Peñaloza López, Xóchitl Daisy Orozco Peña, Santiago Jesús Pérez Ruiz

Abstract
Objective

To evaluate the central auditory processing disorders in patients with multiple sclerosis, emphasizing auditory laterality by applying psychoacoustic tests and to identify their relationship with the Multiple Sclerosis Disability Scale (EDSS) functions.

Method

Depression scales (HADS), EDSS, and 9 psychoacoustic tests to study CAPD were applied to 26 individuals with multiple sclerosis and 26 controls. Correlation tests were performed between the EDSS and psychoacoustic tests.

Results

Seven out of 9 psychoacoustic tests were significantly different (P<.05); right or left (14/19 explorations) with respect to control. In dichotic digits there was a left-ear advantage compared to the usual predominance of RDD. There was significant correlation in five psychoacoustic tests and the specific functions of EDSS.

Conclusion

The left-ear advantage detected and interpreted as an expression of deficient influences of the corpus callosum and attention in multiple sclerosis should be investigated. There was a correlation between psychoacoustic tests and specific EDSS functions.

Resumen
Objetivo

Evaluar los trastornos en procesos centrales de la audición, en pacientes con esclerosis múltiple, enfatizando en lateralidad auditiva mediante la aplicación de pruebas psicoacústicas e identificar la relación de estas con funciones de la Escala de Discapacidad en Esclerosis Múltiple (EDEM).

Método

En 26 individuos con esclerosis múltiple y 26 controles se aplicaron escala de depresión (HADS), EDEM y 9 pruebas psicoacústicas para estudiar trastornos en los procesos centrales de la audición. Se efectuaron pruebas de correlación entre EDEM y pruebas psicoacústicas.

Resultados

Siete de 9 pruebas psicoacústicas fueron diferentes significativamente (p < 0,05); derecha o izquierda (14/19 exploraciones) respecto al grupo control. En dígitos dicóticos la izquierda mostró ventaja de aciertos respecto al predominio usual de dígitos dicóticos en la derecha. Hubo correlación significativa en 5 pruebas psicoacústicas y funciones específicas de la Escala de Discapacidad en Esclerosis Múltiple.

Conclusión

Conviene investigar la ventaja del oído izquierdo detectada como expresión de influencias deficientes del cuerpo calloso y de atención en esclerosis múltiple. Hay correlación entre pruebas psicoacústicas con funciones específicas de EDEM.



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Olfactory Disorder Pattern in Patients With Neurological Diseases Excluding Psychiatric and Traumatic Aetiologies

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Josep de Haro-Licer, Adela González-Fernández, Albert Planas-Comes, Josep Antón González-Ares

Abstract
Introduction

The most common cause of olfactory ENT disorders are colds and flu, chronic sinusitis, allergies and traumatic brain injury. Rarer aetiologies include certain neurological, psychiatric and metabolic injuries.

Target

The aim of this paper was to check the sort of olfactory disorders found in people who have suffered a brain injury, excluding: cranial traumas, psychiatric diseases, epilepsy, Parkinson's and Alzheimer's disease, and synaesthesia.

Material and Methods

A descriptive study based on 61 patients with diagnoses of various neurological injuries, which were tested by BAST-24 olfactometer. The results were compared with those of a control group (n=120).

Results

The results show major impairment in these patients' olfactory sense. The neurological injury patients were able to detect from 60% to 77% of the odours, while the control group were able to detect between 98% and 100%. The neurological patients were able, at best, to identify, 11%–32% of the odours correctly, while the control group were able to correctly detect between 59% and 75%. The differences between odour detection and correct identification were statistically significant (P<.05).

Conclusions

We concluded: (a) Neurological injury, not caused by traumatic brain injury, psychiatric disorders or ENT diseases, ranged from 68% to 89% of the olfactory failures. (b) We must bear in mind that these sorts of injuries can cause olfactory disorders. (c) ENT and Neurologists should collaborate in the treatment of these disorders.

Resumen
Introducción

Las etiologías más frecuente de las patologías olfativas dentro de la otorrinolaringología suelen ser las producidas por resfriados, inflamaciones nasosinusales, alergias y traumatismos craneo-faciales, fuera de estas etiologías tenemos, con menor frecuencia, las enfermedades neurológicas, psiquiátricas, metabólicas. Nuestro servicio ha podido atender a pacientes con alteraciones neurológicas que presentan patologías olfativas.

Objetivo

Este trabajo tiene por finalidad verificar qué tipo de alteraciones olfativas se hallan en las personas que padecen lesiones del sistema nervioso central excluidos los traumatismos craneales, las enfermedades psiquiátricas, las epilepsias, las enfermedades de Parkinson y Alzheimer y las sinestesias.

Material y métodos

Se trata de un estudio descriptivo basado en un grupo de 61 pacientes diagnosticados de diversas lesiones neurológicas y de un grupo control. Ambos grupos fueron valorados por medio del olfatómetro BAST-24. Se comparan los resultados con un grupo control de 120 personas.

Resultados

Los resultados muestran que las personas con estos tipos de lesiones neurológicas tienen una capacidad de percibir olores que oscila entre el 60 y el 77% mientras que el grupo control se sitúa entre el 98 y el 100%. Respecto a la capacidad de reconocer correctamente los olores, los paciente neurológicos no superan el 32% de aciertos, mientras que el grupo control se sitúa entre el 59 y el 75% de aciertos, siendo las diferencias olor a olor presentado estadísticamente significativas (p<0,05) tanto para la detección como para el acierto.

Conclusiones

a) Las alteraciones neurológicas no causadas por traumatismos craneales ni por alteraciones psiquiátricas pueden presentar una pérdida olfativa que oscila entre el 68 y el 89%. b) En este tipo de lesiones debe tenerse en cuenta la presencia de alteraciones olfativas. c) Hay alteraciones olfativas por afectación de otras áreas cerebrales distintas a las clásicas olfativas. d) Debe establecerse una colaboración entre los servicios de ORL y Neurología para poder atender dichas alteraciones.



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Island cartilage vs temporalis fascia in type 1 tympanoplasty: A prospective study

Publication date: November–December 2018

Source: Acta Otorrinolaringologica (English Edition), Volume 69, Issue 6

Author(s): Avani Jain, Sunil Samdani, Man Prakash Sharma, Vinod Meena

Abstract
Objective

(1) To compare the results of graft take-up and audiological outcome of temporalis fascia versus island cartilage graft in type 1 tympanoplasty. (2) To compare the rate of postoperative retraction of neotympanum in both.

Methods

A prospective study was conducted on 70 patients of ages ranging from 11 to 50 years with dry subtotal perforation. 35 underwent island cartilage tympanoplasty and 35 underwent type 1 tympanoplasty using temporalis fascia graft. Graft acceptance rates and post-operative audiograms were compared.

Results

At one year follow up, the graft take-up rate for temporalis fascia and island cartilage graft were found to be 82.9% and 97.1% respectively, which was found to be statistically significant (p < 0.05). In the temporalis fascia group, two out of 35 patients (5.7%) had retraction of the neo tympanum. There was no incidence of retraction using island cartilage graft. There was no significant difference in the postoperative air-bone gap gain between temporalis fascia graft and island cartilage graft.

Conclusion

Island cartilage tympanoplasty shows a high degree of reliability in high risk cases. It has a higher graft take-up rate with no incidence of retraction of neotympanum. Moreover, it provided significant hearing improvement in our patients.

Resumen
Objetivo

1) Comparar los resultados del injerto y el resultado audiológico de la fascia del músculo temporal versus injerto de cartílago en isla en la timpanoplastia tipo 1, y 2) Comparar la tasa de retracción postoperatoria del neotímpano en ambos.

Métodos

Se realizó un estudio prospectivo en 70 pacientes de edades comprendidas entre los 11 y 50 años con perforación subtotal en seco. En 35 de ellos se realizó timpanoplastia con cartílago en isla y a los 35 restantes timpanoplastia tipo 1 mediante injerto de fascia de músculo temporal. Se compararon las tasas de aceptación del injerto y los audiogramas postoperatorios.

Resultados

Al año de seguimiento, la tasa de toma del injerto de fascia de músculo temporal y el injerto de cartílago en isla fue del 82,9 y 97,1%, respectivamente, que resultó estadísticamente significativa (p < 0,05). En el grupo de fascia de músculo temporal, 2 de 35 pacientes (5,7%) tuvieron una retracción del neotímpano. No hubo incidencia de retracción en el injerto de cartílago en isla. No hubo diferencia significativa en cuanto a la ganancia en el umbral diferencial de audición entre los injertos de fascia de músculo temporal y cartílago en isla.

Conclusión

La timpanoplastia con cartílago en isla muestra un alto grado de fiabilidad en casos de alto riesgo. Tiene una mayor tasa de aceptación del injerto, sin incidencias de retracción del neotímpano. Además, aportó una importante mejora de audición a nuestros pacientes.



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Soil Remediation Practices for Hydrocarbon and Heavy Metal Reclamation in Mining Polluted Soils

The study assessed the pollution, biodegradation rates, and phytoaccumulation of total petroleum hydrocarbons (TPHs), Lead (Pb), Cadmium (Cd), and Arsenic (As) in soils in the wet and dry seasons and compared them with set standards. Ten samples of 1kg each were randomly collected and mixed for each site that is the upgradient control site (10 strata design) and the downgradient contaminated site (16 strata design) to make a composite sample for each site. Three representative samples were collected and replicated for four months on both sites. Pot experiments were run with the same concentration levels of TPHs, Pb, As, and Cd. Each pot experiment was also replicated four times for tobacco compost, chicken droppings, Brassica juncea, and the control. Inductive Coupled Spectrometry, SPSS, ANOVA, t-test, normality, and post hoc tests were carried out for analysis. TPHs, Pb, As, and Cd concentrations were significantly higher (pPb>Cd>As. Bioremediation in a controlled experiment revealed that Chicken Droppings and Brassica juncea were effective in reclaiming TPHs, As, and Cd while Tobacco Compost was effective in reclaiming Pb. The highest mean concentrations of Pb, As, and Cd were found in Brassica juncea in the following increasing order: roots, stem, and leaves, respectively.

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Hypothalamic hypopituitarism secondary to suprasellar metastases from small cell lung cancer: a case report and review of the literature

Metastasis to the pituitary gland is an infrequent clinical problem, and the symptoms caused by metastases have been reported in only 2.5–18.2% of the cases. However, metastasis to the suprasellar lesion has r...

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