Medicine by Sfakianakis Alexandros: 11/13/16

Κυριακή 13 Νοεμβρίου 2016

Prognostic factors and outcomes of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer - A single tertiary institution experience.

Prognostic factors and outcomes of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer - A single tertiary institution experience.

J BUON. 2016 Sept-Oct;21(5):1176-1183

Authors: Kocic M, Nikolic S, Zegarac M, Djurisic I, Soldatovic I, Milenkovic P, Kocic J

Abstract
PURPOSE: Ovarian cancer (OC) ranks fifth in mortality among females cancer patients. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) have radically changed the treatment of OC. The aim of this study was to evaluate overall survival (OS) and disease-free survival (DFS) in our patient population after the application of combined CRS and HIPEC treatment.
METHODS: The study included patients who met defined inclusion and exclusion criteria and had undergone CRS of peritoneal carcinomatosis from 2006 to 2011. Tumor extension was intraoperatively calculated using peritoneal cancer index (PCI). After CRS had been performed, selected patients underwent closed HIPEC. Assessment of successful surgery was estimated with the completeness of cytoreduction score.
RESULTS: The study involved 31 patients. The median DFS was 19 months. The DFS for 1 and 2-year period were 69.2 and 35.2%, respectively. The mean OS was 51 months. The 1-, 2- and 5-year OS was 85.4, 63.3 and 56.3%, respectively. PCI ranged from 1 to 24 and the majority (77.4%) of the patients had PCI score below 13. The most frequent carcinomatosis was observed in the omentum (80.6%), followed by adnexae (61.3%), uterus (58.1%), colon (58.1%). spleen (25.8%), diaphragm (25.8%), small intestine (19.4%), bursa omentalis 19.4, liver (9.7%), and pancreas (3.2%).
CONCLUSION: The results of the current study are in concordance with the literature which clearly favors combined the CRS and HIPEC treatment. The reported data suggest that this method could be successfully applied in our region and outline the necessity of future multicentric studies that will involve major regional hospitals.

PMID: 27837620 [PubMed - in process]

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Quality of life in long-term premenopausal early-stage breast cancer survivors from Spain. Effects of surgery and time since surgery.

Quality of life in long-term premenopausal early-stage breast cancer survivors from Spain. Effects of surgery and time since surgery.

J BUON. 2016 Sept-Oct;21(5):1090-1098

Authors: Ignacio Arraras J, Juan Illarramendi J, de la Cruz S, Asin G, Manterola A, Ibanez B, Salgado E, Cambra K, Zarandona U, Angel Dominguez M, Vera R

Abstract
PURPOSE: More research is needed into Quality of Life (QoL) in young early-stage breast cancer patients in the long-term. Knowledge of long-term effects of surgery on QoL in breast cancer patients is limited. The purpose of this study was to assess QoL in premenopausal Spanish early- stage breast cancer patients over a long follow-up period and evaluate differences among surgery-treated groups and the influence of time on patient QoL.
METHODS: 243 premenopausal stage I-III relapse-free breast cancer patients completed the EORTC QLQ-C30 and QLQ-BR23 questionnaire once during follow-up (5-20 years after surgery). Univariate and multivariate logistic regression analyses were performed to estimate the results.
RESULTS: QoL mean scores were high in most areas (>80 points in functioning: <20 points in symptoms areas). Limitations were moderate (>30 points) in global QoL, sleep disturbance, future perspective, sexual areas, and hot flashes. Mastectomized patients had a 4-fold greater risk of low scores in body image. Patients with a longer follow-up showed lower systemic side effects, hot flashes and breast symptoms.
CONCLUSIONS: QoL in Spanish premenopausal early-stage breast cancer patients in a long follow-up after surgery is high. Differences in QoL among surgery-treated groups are limited. Time since surgery influences treatment side effects.

PMID: 27837609 [PubMed - in process]

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Simplified Tai Chi Program Training versus Traditional Tai Chi on the Functional Movement Screening in Older Adults

Background. The present study aimed to evaluate and compare the effect of two different types of Tai Chi programs on the Functional Movement Screening (FMS) in older adults. Methods. Ninety older adults (65.5 ± 4.6 years old) who met the eligibility criteria were randomized into three different groups based on a ratio of 1 : 1 : 1: a traditional Tai Chi exercise (TTC), a simplified Tai Chi exercise (TCRT), or a control group (routine activity). The FMS consisted of the deep squat, hurdle step, in-line lunge, shoulder mobility, active straight leg rise, trunk stability push-up, and rotatory stability, which was used to measure physical function before the present study and after six months of Tai Chi interventions. Results. Seventy-nine participants completed the present study (control = 27, TTC = 23, and TCRT = 29). Significant improvement on the FMS tests between the baseline and after the six-month intervention was observed in both Tai Chi programs, whereas no significant improvement was observed in the control group. In addition, participants in the TCRT group demonstrated greater improvement than those in the TTC group. Conclusions. The TCRT is more effective in improving the physical function in older adults when compared to the traditional Tai Chi modality, particularly for improving balance.

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Plasmablastic lymphoma: oral presentation in patient suffering from osteradionecrosis of the jaw.

Plasmablastic lymphoma: oral presentation in patient suffering from osteradionecrosis of the jaw.

Int J Surg Case Rep. 2016 Nov 3;29:94-97

Authors: Kichenbrand C, Egloff C, Guillet J, Delaître B, Bastien C, Leroux A, Dolivet G, Phulpin B

Abstract
INTRODUCTION: We describe here an unusual presentation of a plasmablastic lymphoma in a patient suffering from an osteoradionecrosis of the jaw.
PRESENTATION OF CASE: We report the case of a 64-year-old patient who was followed up on oncology because of an oropharyngeal cancer treated by a combined procedure of both surgery and radio-chemotherapy procedure. This patient developed an osteoradionecrosis of the jaw. In the vicinity of this necrotic area appeared an ulceration which could evoke a new necrotic area. Given the persistence of this ulceration, a biopsy was performed which highlighted a plasmablastic lymphoma oral localization.
DISCUSSION: The plasmablastic lymphoma, belonging to the diffuse large B-cell lymphoma family, is a very aggressive and unusual form of cancer with poor prognosis. If it is found mainly in patients with positive HIV, in whom it was first described, it is also found in immunosuppressed patients such as transplanted patients or patients suffering from leukaemia.
CONCLUSION: Plasmablastic lymphoma is a rare and an aggressive pathology in immunocompetent patients.

PMID: 27837702 [PubMed - as supplied by publisher]

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In vivo dosimetry in the field junction area for 3D-conformal radiation therapy in breast and head & neck cancer cases: A quality assurance study.

In vivo dosimetry in the field junction area for 3D-conformal radiation therapy in breast and head & neck cancer cases: A quality assurance study.

J BUON. 2016 Sept-Oct;21(5):1104-1112

Authors: Diamantopoulos S, Thalassinou S, Efstathopoulos E, Dilvoi M, Patatoukas G, Kouloulias V, Platoni K

Abstract
PURPOSE: To investigate the accuracy of field junctioning planning techniques (monoisocentric and rotating couch technique) for 3D-conformal radiotherapy (3D-CRT).
METHODS: In vivo dosimetry has been performed using thermo- luminescence dosimeters (TLDs) in 10 head and neck cancer patients (treated with monoisocentric technique) and 10 breast cancer patients (treated with rotating couch technique) irradiated with a 6 MV photon beam. Entrance dose measurements were performed in selected regions including the field junction area.
RESULTS: The mean deviation between measured and expected dose in the region of junction was significantly higher in breast cases compared to head and neck irradiation (-2.8±15.4% and 0.2±8.2% respectively; Mann-Whitney U test: p=0.002). A comparison between lateral head and neck fields and tangential breast fields revealed that the latter was associated with larger dose discrepancies (-2.2 ± 4.6% vs -3.5 ± 5.7% respectively; Mann-Whitney U test: p=0.029).
CONCLUSIONS: The results indicate the superiority of monoisocentric technique compared to the rotating couch technique in terms of dose delivery accuracy for treatments with field junctioning planning techniques.

PMID: 27837611 [PubMed - in process]

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An unusual giant isolated mucosal malignant melanoma of nasal cavity – A case report

Publication date: Available online 12 November 2016
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Author(s): Santosh Kumar Swain, Mahesh Chandra Sahu
The mucosal malignant melanoma arises from the melanocytes present in the mucosal membrane. It carries a poor prognosis due to local recurrence, neck node involvement and distant metastasis, making it difficult to identify the possible treatment. The key and critical issue for the management of the malignant melanoma of the nasal cavity is early diagnosis in order to start primary modality of treatment like surgical excision and radiotherapy with adequate follow up. We report a case of malignant melanoma of the nasal cavity in a 65years old male with presentation of recurrent epistaxis and nasal obstruction. Rarity of this isolated lesion confined to nasal cavity with a giant size warrants its attention for reporting this case.

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Epidermal growth factor receptor (EGFR) pathway polymorphisms as predictive markers of cetuximab toxicity in locally advanced head and neck squamous cell carcinoma (HNSCC) in a Spanish population

Publication date: December 2016
Source:Oral Oncology, Volume 63
Author(s): J. Fernández-Mateos, R. Seijas-Tamayo, R. Mesía, M. Taberna, M. Pastor Borgoñón, E. Pérez-Ruiz, J.C. Adansa Klain, S. Vázquez Fernández, E. del Barco Morillo, A. Lozano, R. González Sarmiento, J.J. Cruz-Hernández
ObjectivesTo examine the relationship between polymorphisms of the epidermal growth factor receptor (EGFR) pathway and toxicity in head and neck squamous cell carcinoma (HNSCC) patients treated with cetuximab.Material and methodsMulticenter, retrospective, observational pilot study which included 110 patients with histologically-confirmed human papillomavirus (HPV) negative HNSCC in locally advanced stages (III-IVA-B) and who were treated with chemotherapy and radiotherapy plus cetuximab between 2003 and 2013. Genetic analyses for single nucleotide polymorphisms (SNP) in genes EGFR, CCDN1, FCGR2A, FCGR3A and KRAS-LCS6 were performed though available allelic discrimination assay and/or polymerase chain reaction-restriction fragment length polymorphism methods.ResultsAcneiform rash was observed in 55.5% of patients, dry skin in 45.5% and pruritus in 20.9%. A significant association with dry skin and global cetuximab-related toxicity was observed for the KRAS-LCS6 (rs61764370) variant (p<0.05); carriers of the G allele (genotypes TG+GG) in the dominant model were observed to have a decreased susceptibility of developing dry skin (OR=0.287 [95%CI=0.119–0.695]). Carriers of the A (GA+AA) allele for EGFR (rs2227983) showed a decreased risk of suffering from pruritus (OR=0.345 [0.124–0.958]). Similarly, KRAS (rs1801274) was related with lower global cetuximab-related toxicity (OR=0.266 [0.114–0.622]).ConclusionThis pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy. Alternative therapeutic options should be explored for these patients.

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An unusual giant isolated mucosal malignant melanoma of nasal cavity – A case report

HR+/Her2- breast cancer in pre-menopausal women: The impact of younger age on clinical characteristics at diagnosis, disease management and survival

Publication date: December 2016
Source:Cancer Epidemiology, Volume 45
Author(s): Marianna De Camargo Cancela, Harry Comber, Linda Sharp
Young women (20–39 years-old) with breast cancer are diagnosed with more aggressive tumours and consequently have poorer survival. However, there is an evidence gap as to whether age has an independent effect on survival of pre-menopausal women diagnosed with HR+/Her2- tumours. The aim of this population-based study was to compare characteristics at diagnosis, determinants of treatment and survival in women aged 20–39 and 40–49 years diagnosed with HR+/Her2- tumours. From the National Cancer Registry Ireland, we identified women aged 20–49 diagnosed with a first invasive HR+/Her2- breast cancer during 2002–2008. Women aged 20–39 were compared to those aged 40–49 years. Poisson regression with robust error variance was used to explore the impact of age on treatment receipt. Associations between age and survival from all causes was investigated using Cox models. In multivariate models, women aged 20–39 significantly more often having no cancer-directed surgery (IRR=1.49, 95%CI 1.07, 2.08). In those having surgery, younger age was associated with significantly higher likelihood of receiving chemotherapy; age was not associated with receipt of adjuvant radiotherapy or endocrine therapy. Women aged 20–39 undergoing surgery were significantly more likely to die than women aged 40–49 (HR=1.84, 95%CI: 1.31, 2.59). Age is an independent prognostic factor in younger women diagnosed with HR+/Her2- breast cancer, supporting the hypothesis that breast cancer in women under 40 has more aggressive behaviour, even within HR+/Her2- tumours. Future research should explore the reasons for poorer survival in order to inform strategies to improve outcomes in this age group.

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Enrolment of young women attending cervical cancer screening to survey effectiveness of HPV vaccination

Publication date: Available online 12 November 2016
Source:Cancer Epidemiology
Author(s): Marc Arbyn, Davy Vanden Broeck, Johannes Bogers, Pierre Van Damme, Marleen Temmerman, Steven Weyers

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Epidermal growth factor receptor (EGFR) pathway polymorphisms as predictive markers of cetuximab toxicity in locally advanced head and neck squamous cell carcinoma (HNSCC) in a Spanish population

Continuous infusion of human prothrombin complex in a patient with congenital factor VII deficiency undergoing laparoscopic cholecystectomy: A case report from China.

Continuous infusion of human prothrombin complex in a patient with congenital factor VII deficiency undergoing laparoscopic cholecystectomy: A case report from China.

Int J Surg Case Rep. 2016 Oct 23;29:98-99

Authors: Zhou R, Chen Q, Huang X, Wang M

Abstract
INTRODUCTION: Factor VII deficiency is a rare cause of haemorrhagic syndrome.
PRESENTATION OF CASE: The authors describe a case of a 48 years old patient with congenital factor VII deficiency suffering abdominal discomfort diagnosed as gallstone, that successfully underwent laparoscopic cholecystectomy with continuous infusion of Human Prothrombin Complex(PPSB) around the procedure.
CONCLUSION: The usage of PPSB solved the clotting problems enabling the surgical procedure, without risks for the patient.

PMID: 27837703 [PubMed - as supplied by publisher]

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Plasmablastic lymphoma: oral presentation in patient suffering from osteradionecrosis of the jaw.

Plasmablastic lymphoma: oral presentation in patient suffering from osteradionecrosis of the jaw.

Int J Surg Case Rep. 2016 Nov 3;29:94-97

Authors: Kichenbrand C, Egloff C, Guillet J, Delaître B, Bastien C, Leroux A, Dolivet G, Phulpin B

PMID: 27837702 [PubMed - as supplied by publisher]

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Subcutaneous metastases from early stage esophageal adenocarcinoma case report.

Subcutaneous metastases from early stage esophageal adenocarcinoma case report.

Int J Surg Case Rep. 2016 Oct 29;29:108-112

Authors: Datta S, Muñoz-Largacha JA, Li L, Zhao GQ, Litle VR

Abstract
The identification of subcutaneous metastatic lesions from primary visceral malignancies has increased over time, probably due to an increase in the awareness of their presentation and an increase in cancer survival times. Although the rate of subcutaneous metastases from breast,lung and colon cancer is more significant, the incidence of subcutaneous metastases from esophageal carcinomas is very low. These metastatic lesions usually present metachronously and may signify advanced disease and poor prognosis. We report three cases with early stage esophageal adenocarcinoma treated with surgery with curative intent presenting with subcutaneous metastases two months, two years and three years after their esophagectomy.

PMID: 27837701 [PubMed - as supplied by publisher]

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Ultrasound-guided intranodal lipiodol lymphangiography from the groin is useful for assessment and treatment of post-esophagectomy chylothorax in three cases.

Ultrasound-guided intranodal lipiodol lymphangiography from the groin is useful for assessment and treatment of post-esophagectomy chylothorax in three cases.

Int J Surg Case Rep. 2016 Nov 3;29:103-107

Authors: Liu J, Sato Y, Motoyama S, Ishiyama K, Yamada K, Yamamoto M, Wakita A, Kawakita Y, Imai K, Saito H, Hashimoto M, Minamiya Y

Abstract
INTRODUCTION: Ultrasound-guided intranodal lipiodol lymphangiography (LAG) from the groin is a recently introduced technique for diagnosing and treating postoperative chylothorax. The benefits of this technique include reduced technical difficulty and shorter procedure duration, as compared to traditional pedal LAG. Although these benefits may eventually increase utilization of intranodal LAG, reports are still few.
PRESENTATION OF CASES: Herein, we report three cases of post-esophagectomy chylothorax in whom ultrasound-guided intranodal lipiodol LAG from the groin were successfully performed with no complications. Leak points were clearly identified in the three cases. Cure was obtained in one case by the LAG only. Surgical ligations were performed after LAG in two cases and cures were achieved.
DISCUSSION: If LAG successfully cured chylothorax, chest drain output would decrease dramatically and the leaked lipiodol could be confirmed near the leak point in plain computerized tomography (CT) in the following 1-2days. But if LAG failed to cure, chest drain output would be unchanged and the leaked lipiodol would be found diffusing in the surrounding.
CONCLUSION: Ultrasound-guided intranodal lipiodol LAG from the groin is a minimally invasive and easily performed procedure with high diagnostic and therapeutic value for postoperative chylothorax. If LAG failed to cure, conservative management is often insufficient and surgical ligation should be performed as soon as possible.

PMID: 27837700 [PubMed - as supplied by publisher]

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Reply

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Hadi Maazi, Yuzo Suzuki, Jae Jung, Omid Akbari

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A possible differential role of autophagy in asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Ulaganathan Mabalirajan

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Proficient DNA repair in house dust mite–induced asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Rakhshinda Rehman, Ulaganathan Mabalirajan

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Hematopoietic Stem Cell Transplant in Patients with Activated PI3K Delta Syndrome

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Zohreh Nademi, Mary A. Slatter, Christopher C. Dvorak, Benedicte Neven, Alain Fischer, Felipe Suarez, Claire Booth, Kanchan Rao, Alexandra Laberko, Julia Rodina, Yves Bertrand, Sylwia Kołtan, Robert Dębski, Terence Flood, Mario Abinun, Andrew R. Gennery, Sophie Hambleton, Stephan Ehl, Andrew J. Cant

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Reply

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Hadi Maazi, Yuzo Suzuki, Jae Jung, Omid Akbari

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A possible differential role of autophagy in asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Ulaganathan Mabalirajan

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Proficient DNA repair in house dust mite–induced asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Rakhshinda Rehman, Ulaganathan Mabalirajan

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Hematopoietic Stem Cell Transplant in Patients with Activated PI3K Delta Syndrome

Two Different Life-Threatening Cases: Presenting with Torticollis

Acquired torticollis can be the result of several different pathological mechanisms. It is generally related to trauma, tumors, and inflammatory processes of the cervical muscles, nerves, and vertebral synovia. Although upper respiratory tract and neck inflammation are common causes of acute febrile torticollis in children, diseases with as yet undefined relationships may also result in torticollis. This is the case of spinal arachnoid cyst and pneumonia.

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Fully Implanted Brain–Computer Interface in a Locked-In Patient with ALS

New England Journal of Medicine, Ahead of Print.

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Two Different Life-Threatening Cases: Presenting with Torticollis

Tumorigenicity and Validity of Fluorescence Labelled Mesenchymal and Epithelial Human Oral Cancer Cell Lines in Nude Mice

Tumorigenicity and metastatic activity can be visually monitored in cancer cells that were labelled with stable fluorescence. The aim was to establish and validate local and distant spread of subcutaneously previously injected fluorescence transduced human tongue cancer cell lines of epithelial and mesenchymal phenotype in nude mice. A total of 32 four-week-old male athymic Balb/c nude mice were randomly allocated into 4 groups (). A single dose of 0.3 mL PBS containing 1 × 107 of four different cancer cell-lines (UM1, UM1-GFP, UM2, and UM2-RFP) was injected subcutaneously into the right side of their posterolateral back. Validity assessment of the labelled cancer cells' tumorigenicity was assessed by physical examination, imaging, and histology four weeks after the injection. The tumor take rate of cancer cells was similar in animals injected with either parental or transduced cancer cells. Transduced cancer cells in mice were easily detectable in vivo and after cryosection using fluorescent imaging. UM1 cells showed increased tumor take rate and mean tumor volume, presenting with disorganized histopathological patterns. Fluorescence labelled epithelial and mesenchymal human tongue cancer cell lines do not change in tumorigenicity or cell phenotype after injection in vivo.

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The Gut Microbial Community of Antarctic Fish Detected by 16S rRNA Gene Sequence Analysis

Intestinal bacterial communities are highly relevant to the digestion, nutrition, growth, reproduction, and a range of fitness in fish, but little is known about the gut microbial community in Antarctic fish. In this study, the composition of intestinal microbial community in four species of Antarctic fish was detected based on 16S rRNA gene sequencing. As a result, 1 004 639 sequences were obtained from 13 samples identified into 36 phyla and 804 genera, in which Proteobacteria, Actinobacteria, Firmicutes, Thermi, and Bacteroidetes were the dominant phyla, and Rhodococcus, Thermus, Acinetobacter, Propionibacterium, Streptococcus, and Mycoplasma were the dominant genera. The number of common OTUs (operational taxonomic units) varied from 346 to 768, while unique OTUs varied from 84 to 694 in the four species of Antarctic fish. Moreover, intestinal bacterial communities in individuals of each species were not really similar, and those in the four species were not absolutely different, suggesting that bacterial communities might influence the physiological characteristics of Antarctic fish, and the common bacterial communities might contribute to the fish survival ability in extreme Antarctic environment, while the different ones were related to the living habits. All of these results could offer certain information for the future study of Antarctic fish physiological characteristics.

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Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer cells. In this study, we investigate the anticancer properties of OMT on human glioblastoma (GBM) cells and evaluate their underlying mechanisms. MTT assays were performed and demonstrated that OMT significantly inhibits the proliferation of GBM cells. Flow cytometry suggested that OMT at a concentration of 10−5 M may induce apoptosis in U251 and A172 cells. Western blot analyses demonstrated a significant increase in the expression of Bax and caspase-3 and a significant decrease in expression of Bcl-2 in both U251 and A172 cells. Additionally, OMT was found by transwell and high-content screening assays to decrease the migratory ability of the evaluated GBM cells. These findings suggest that the antitumor effects of OMT may be the result of inhibition of cell proliferation and migration and the induction of apoptosis by regulating the expression of apoptosis-associated proteins. OMT may represent a novel anticancer therapy for the treatment of GBM.

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Intake, Nutrient Apparent Digestibility, and Ruminal Constituents of Crossbred Dorper × Santa Inês Sheep Fed Diets with Babassu Mesocarp Flour

The aim of this study was to evaluate the effect on intake, apparent digestibility, and ruminal constituents of sheep in response to the addition of increasing levels of babassu mesocarp flour (BMF) to the diet. Twenty crossbred sheep ( kg) were used in a randomized complete block design. Lambs were confined for 21 days, with 16 days for diet adaptation and 5 days for data collection, in which they were fed an isonitrogenous diet ( CP, DM basis) containing 70% of concentrate and 30% (DM basis) of Tifton 85 hay. Increasing levels of BMF were 0, 10, 20, and 30% (DM basis). There was a quadratic effect () on the DM intake, nutrients intake, and digestibility of CP and NFC. The digestibility of DM, OM, TC, and NDF decreased linearly, while EE digestibility increased linearly with increasing levels of BMF. The high NDF content presented in the chemical composition of the babassu mesocarp flour ranked the same as fibrous food, which can limit the inclusion in the diet of high production animals. So, babassu mesocarp flour is an alternative for energy source in lambs feed and can be added at levels up to 10%.

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Performance of pile-up mitigation techniques for jets in pp collisions at √s=8 TeV using the ATLAS detector

Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; AbouZeid, OS; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; AbouZeid, OS; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, BS; Adamczyk, L; Adams, DL; Adelman, J; Adomeit, S; Adye, T; Affolder, AA; Agatonovic-Jovin, T; Agricola, J; Aguilar-Saavedra, JA; Ahlen, SP; Ahmadov, F; Aielli, G; Akerstedt, H; Åkesson, TPA; Akimov, AV; Alberghi, GL; Albert, J; Albrand, S; Verzini, MJA; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, SP; Allbrooke, BMM; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, BA; Piqueras, DÁ; Alviggi, MG; Amadio, BT; Amako, K; Coutinho, YA; Amelung, C; Amidei, D; Dos Santos, SPA; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, G; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, AV; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; - view fewer (2016) Performance of pile-up mitigation techniques for jets in pp collisions at √s=8 TeV using the ATLAS detector. European Physical Journal C , 76 (11) 10.1140/epjc/s10052-016-4395-z .

http://discovery.ucl.ac.uk/1528599/

Food, families and work: children's changing food practices in the context of parental employment

O'Connell, RE; Brannen, J; (2016) Food, families and work: children's changing food practices in the context of parental employment. Discover Society

http://discovery.ucl.ac.uk/1528598/

Open archives: institutional issues

Ayris, P; (2001) Open archives: institutional issues. VINE , 31 (4) pp. 34-37. 10.1108/03055720010804258 .

http://discovery.ucl.ac.uk/1528597/

The Architecture of Planning through the Multiple Sites of Mapping in the Periphery of Lima, Peru

Lambert, RC; The Architecture of Planning through the Multiple Sites of Mapping in the Periphery of Lima, Peru. Presented at: Inside Planning- Ontology, Publics, Organization Knowledge, Agenda, Valuation, Munich.

http://discovery.ucl.ac.uk/1528596/

José Carlos Mariátegui: Riesgos Cotidianos y Desastres episódicos

Lambert, RC; Rickles, P; Espinoza, F; (2016) José Carlos Mariátegui: Riesgos Cotidianos y Desastres episódicos. [Digital scholarly resource]. http://arcg.is/1FkV5MD

http://discovery.ucl.ac.uk/1528595/

Barrios Altos: Riesgos Cotidianos y Desastres episódicos

Lambert, RC; Rickles, P; Belkow, T; Woo, MI; (2016) Barrios Altos: Riesgos Cotidianos y Desastres episódicos. [Digital scholarly resource]. http://arcg.is/1FkV5MD

http://discovery.ucl.ac.uk/1528594/

Participatory Mapping to Reduce Urban Risk in Lima

Lambert, RC; Participatory Mapping to Reduce Urban Risk in Lima. cLIMA sin Riesgo, DPU-UCL, London.

http://discovery.ucl.ac.uk/1528593/

Participatory Mapping to Disrupt Unjust Urban Trajectories in Lima

Lambert, RC; Allen, A; (2016) Participatory Mapping to Disrupt Unjust Urban Trajectories in Lima. In: Imperatore, P and Pepe, A, (eds.) Geospatial Technology - Environmental and Social Applications. (pp. 143-165). INTech: Croatia.

http://discovery.ucl.ac.uk/1528592/

Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism.

Watanabe, T; Otowa, T; Abe, O; Kuwabara, H; Aoki, Y; Natsubori, T; Takao, H; Watanabe, T; Otowa, T; Abe, O; Kuwabara, H; Aoki, Y; Natsubori, T; Takao, H; Kakiuchi, C; Kondo, K; Ikeda, M; Iwata, N; Kasai, K; Sasaki, T; Yamasue, H; - view fewer (2016) Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism. Soc Cogn Affect Neurosci 10.1093/scan/nsw150 .

http://discovery.ucl.ac.uk/1528591/

Indentation of the Pamirs with respect to the northern margin of Tibet: Constraints from the Tarim basin sedimentary record

Blayney, T; Najman, Y; Dupont-Nivet, G; Carter, A; Millar, I; Garzanti, E; Sobel, ER; Blayney, T; Najman, Y; Dupont-Nivet, G; Carter, A; Millar, I; Garzanti, E; Sobel, ER; Rittner, M; Andò, S; Guo, Z; Vezzoli, G; - view fewer (2016) Indentation of the Pamirs with respect to the northern margin of Tibet: Constraints from the Tarim basin sedimentary record. Tectonics 10.1002/2016TC004222 . (In press).

http://discovery.ucl.ac.uk/1528590/

Late Cretaceous-earliest Paleogene deformation in the Longmen Shan fold-and-thrust belt, eastern Tibetan Plateau margin: Pre-Cenozoic thickened crust?

Tian, Y; Kohn, BP; Phillips, D; Hu, S; Gleadow, AJW; Carter, A; (2016) Late Cretaceous-earliest Paleogene deformation in the Longmen Shan fold-and-thrust belt, eastern Tibetan Plateau margin: Pre-Cenozoic thickened crust? Tectonics 10.1002/2016TC004182 . (In press).

http://discovery.ucl.ac.uk/1528589/

Cenozoic landforms and post-orogenic landscape evolution of the Balkanide orogen: Evidence for alternatives to the tectonic denudation narrative in southern Bulgaria

Gunnell, Y; Calvet, M; Meyer, B; Pinna-Jamme, R; Bour, I; Gautheron, C; Carter, A; Gunnell, Y; Calvet, M; Meyer, B; Pinna-Jamme, R; Bour, I; Gautheron, C; Carter, A; Dimitrov, D; - view fewer (2017) Cenozoic landforms and post-orogenic landscape evolution of the Balkanide orogen: Evidence for alternatives to the tectonic denudation narrative in southern Bulgaria. Geomorphology , 276 pp. 203-221. 10.1016/j.geomorph.2016.10.015 . (In press).

http://discovery.ucl.ac.uk/1528588/

Reading by apprenticeship?

Beard, R; Oakhill, J; (1995) Reading by apprenticeship? Language Learning pp. 36-37.

http://discovery.ucl.ac.uk/1528587/

Evaluating Further Literacy Support

Beard, R; Shorrocks-Taylor, D; Pell, G; (2004) Evaluating Further Literacy Support. Literacy Today (18) pp. 20-21.

http://discovery.ucl.ac.uk/1528586/

Evaluation of the Holocaust Educational Trust's Lessons from Auschwitz Project.

Chapman, AJ; Gutman, L; Sehmi, R; Edwards, C; Himonides, E; (2016) Evaluation of the Holocaust Educational Trust's Lessons from Auschwitz Project. UCL Institute of Education: London.

http://discovery.ucl.ac.uk/1528585/

PrEP: why we are waiting.

Jansen, MP; Tromp, N; Baltussen, R; (2016) PrEP: why we are waiting. Lancet HIV , 3 (1) e11-e12. 10.1016/S2352-3018(15)00250-7 .

http://discovery.ucl.ac.uk/1528584/

Interdependence and dynamics of essential services in an extensive risk context: a case study in Montserrat, West Indies

Sword-Daniels, VL; Rossetto, T; Wilson, TM; Sargeant, S; (2015) Interdependence and dynamics of essential services in an extensive risk context: a case study in Montserrat, West Indies. Natural Hazards and Earth System Sciences Discussions , 3 (2) pp. 1025-1059. 10.5194/nhessd-3-1025-2015 .

http://discovery.ucl.ac.uk/1528583/

Radio-controlled Movement of a Robot Endoscope in the Human Gastrointestinal Tract

Swain, C; Mills, TN; Kelleher, B; Mosse, CA; Burke, MPD; Fritcher-Ravens, A; (2005) Radio-controlled Movement of a Robot Endoscope in the Human Gastrointestinal Tract. In: (Proceedings) American Society for Gastrointestinal Endoscopy's 'Digestive Disease Week. (pp. AB101-AB101). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528582/

Development and Testing of an Electrically Propelled Capsule Endoscope in Man

Fritscher-Ravens, A; Burke, MPD; Mills, T; Mosse, CA; Mylonaki, M; Swain, CP; (2003) Development and Testing of an Electrically Propelled Capsule Endoscope in Man. In: (Proceedings) American Society for Gastrointestinal Endoscopy's 'Digestive Disease Week. (pp. AB84-AB84). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528581/

Remote Propulsion of Wireless Capsule Endoscopes

Swain, PC; Mosse, A; Burke, MPD; Fritscher-Ravens, A; Lewkovicz, S; Kraizer, Y; Mills, T; (2002) Remote Propulsion of Wireless Capsule Endoscopes. In: (Proceedings) Digestive Disease Week 2002, May 19 - 22, 2002; San Francisco, Californi. (pp. AB88-AB88). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528580/

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Κυριακή 13 Νοεμβρίου 2016