Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

A 20-year-old Danish woman with melorheostosis in her right femoral shaft and disabling pain in the affected area, whose symptoms did not in the long term respond to zoledronic acid, experienced continuous rem...

https://ift.tt/2IkrpIV

Patients with Indeterminate Thyroid Nodules at Cytology and Cancer at Histology Have a More Favorable Outcome Compared with Patients with Suspicious or Malignant Cytology

Thyroid, Volume 28, Issue 10, Page 1318-1324, October 2018.


https://ift.tt/2zy8nMt

Immune-Related Thyroiditis with Immune Checkpoint Inhibitors

Thyroid, Volume 28, Issue 10, Page 1243-1251, October 2018.


https://ift.tt/2OR7bZy

Future Meetings

Thyroid, Volume 28, Issue 10, Page 1398-1399, October 2018.


https://ift.tt/2zxS9mv

Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice

Thyroid, Volume 28, Issue 10, Page 1372-1386, October 2018.


https://ift.tt/2OXH3fS

Deep Learning–Based Computer-Aided Diagnosis System for Localization and Diagnosis of Metastatic Lymph Nodes on Ultrasound: A Pilot Study

Thyroid, Volume 28, Issue 10, Page 1332-1338, October 2018.


https://ift.tt/2NJxC7b

Intermediate-Risk Papillary Thyroid Cancer: Risk Factors for Early Recurrence in Patients with Excellent Response to Initial Therapy

Thyroid, Volume 28, Issue 10, Page 1311-1317, October 2018.


https://ift.tt/2xUmLwf

Dynamic Risk Stratification in the Follow-Up of Children and Adolescents with Differentiated Thyroid Cancer

Thyroid, Volume 28, Issue 10, Page 1285-1292, October 2018.


https://ift.tt/2NKBJ2w

Diagnostic Performance of Technetium-99m Methoxy-Isobutyl-Isonitrile for Differentiation of Malignant Thyroid Nodules: A Systematic Review and Meta-Analysis

Thyroid, Volume 28, Issue 10, Page 1339-1348, October 2018.


https://ift.tt/2xTt0R5

Iodine Intake is Associated with Thyroid Function in Mild to Moderately Iodine Deficient Pregnant Women

Thyroid, Volume 28, Issue 10, Page 1359-1371, October 2018.


https://ift.tt/2NKBgNO

Survival in Differentiated Thyroid Cancer: Comparing the AJCC Cancer Staging Seventh and Eighth Editions

Thyroid, Volume 28, Issue 10, Page 1301-1310, October 2018.


https://ift.tt/2xTtiaD

Anticonvulsant and Neuroprotective Effects of the Thyroid Hormone Metabolite 3-Iodothyroacetic Acid

Thyroid, Volume 28, Issue 10, Page 1387-1397, October 2018.


https://ift.tt/2NJHoWU

Use of Synthetic Peptides and Multiple Antigen Blot Assay in the Immunodiagnosis of Hepatitis C Virus Infection

Viral Immunology, Ahead of Print.


https://ift.tt/2IktrbN

The Video Head Impulse Test: Our Experience in 45 Cases

Abstract

To evaluate the role of video head impulse test in the diagnosis of peripheral vestibular disorders, we performed an observational study in the outpatient department in a tertiary setup in which the clinical head impulse test and the video head impulse test were performed on 45 patients with clinically suspected peripheral vestibular disorders, and their results were correlated. To analyse our results, each ear was counted individually and hence, among 45 patients, 12 out of 90 ears showed abnormal clinical head impulse test for lateral semicircular canals and 27 out of 90 ears showed abnormal video head impulse test for lateral semicircular canals. This gave us an additional diagnostic accuracy of 21.1% on using video head impulse test for the lateral semicircular canals as compared to the clinical head impulse test. Video head impulse test is a physiological, quick and well tolerated test for assessing the vestibular function, and the only practical test for assessing the vertical semicircular canal function. Video head impulse test provides valuable information in localising the site of lesion as it assesses the semicircular canals individually. Video head impulse is merely not an objectification and registration system for the clinical head impulse test as it provides additional information such as vestibulo–ocular reflex gain, and occurrence of covert refixation saccades which cannot be picked up by naked eyes.

https://ift.tt/2DyFu6M

Physicians’ Perception on Allergic Rhinitis and Its Management: A Questionnaire Based Survey

Abstract

Despite high prevalence and impact on quality of life, Allergic Rhinitis (AR) is undertreated. Furthermore, existence of a relationship between AR and upper respiratory tract infection (URTI) is less explored. This Pan-India survey intended to assess physicians' perception about AR and URTI, and management practices in Indian setting. This questionnaire-based survey was conducted by telephonically interviewing 300 physicians [Consultant Physicians (CP): 33%; General Physicians (GP): 32%; ENT surgeons: 16%; pediatricians: 11%; allergy specialists: 8%] across India. CPs (33%) and GPs (32%) treated more AR patients in a month, versus other specialties. According to physicians, about 29.6% of patients with AR develop URTI in a month. Majority of the physicians (98%) believed that recurrent URTI can be considered as an indicator of undiagnosed AR. Majority of the physicians (98%) also considered AR to be a predisposing factor for increased risk of URTI. About 62% agreed that prompt diagnosis and treatment of AR can reduce the risk of complications such as URTI. Most preferred first- and second-line of treatment (alone or in combination) in AR management were oral antihistamines (41%) and intranasal corticosteroids (40%), respectively. Similar treatment preferences were observed irrespective of physicians' specialization and years of experience. This survey sheds light on the need to implement clear guidelines for the diagnosis and management of AR.

https://ift.tt/2R1w3PR

The Video Head Impulse Test: Our Experience in 45 Cases

Abstract

To evaluate the role of video head impulse test in the diagnosis of peripheral vestibular disorders, we performed an observational study in the outpatient department in a tertiary setup in which the clinical head impulse test and the video head impulse test were performed on 45 patients with clinically suspected peripheral vestibular disorders, and their results were correlated. To analyse our results, each ear was counted individually and hence, among 45 patients, 12 out of 90 ears showed abnormal clinical head impulse test for lateral semicircular canals and 27 out of 90 ears showed abnormal video head impulse test for lateral semicircular canals. This gave us an additional diagnostic accuracy of 21.1% on using video head impulse test for the lateral semicircular canals as compared to the clinical head impulse test. Video head impulse test is a physiological, quick and well tolerated test for assessing the vestibular function, and the only practical test for assessing the vertical semicircular canal function. Video head impulse test provides valuable information in localising the site of lesion as it assesses the semicircular canals individually. Video head impulse is merely not an objectification and registration system for the clinical head impulse test as it provides additional information such as vestibulo–ocular reflex gain, and occurrence of covert refixation saccades which cannot be picked up by naked eyes.

https://ift.tt/2DyFu6M

Physicians’ Perception on Allergic Rhinitis and Its Management: A Questionnaire Based Survey

Abstract

Despite high prevalence and impact on quality of life, Allergic Rhinitis (AR) is undertreated. Furthermore, existence of a relationship between AR and upper respiratory tract infection (URTI) is less explored. This Pan-India survey intended to assess physicians' perception about AR and URTI, and management practices in Indian setting. This questionnaire-based survey was conducted by telephonically interviewing 300 physicians [Consultant Physicians (CP): 33%; General Physicians (GP): 32%; ENT surgeons: 16%; pediatricians: 11%; allergy specialists: 8%] across India. CPs (33%) and GPs (32%) treated more AR patients in a month, versus other specialties. According to physicians, about 29.6% of patients with AR develop URTI in a month. Majority of the physicians (98%) believed that recurrent URTI can be considered as an indicator of undiagnosed AR. Majority of the physicians (98%) also considered AR to be a predisposing factor for increased risk of URTI. About 62% agreed that prompt diagnosis and treatment of AR can reduce the risk of complications such as URTI. Most preferred first- and second-line of treatment (alone or in combination) in AR management were oral antihistamines (41%) and intranasal corticosteroids (40%), respectively. Similar treatment preferences were observed irrespective of physicians' specialization and years of experience. This survey sheds light on the need to implement clear guidelines for the diagnosis and management of AR.

https://ift.tt/2R1w3PR

VideoEndocrinology™ High-Impact Videos

VideoEndocrinology™
The Official Journal of: American Thyroid Association

FREE ACCESS through October 8, 2018.
Watch now:

Transoral Endoscopic Thyroidectomy Vestibular Approach: Technical Tips and Tricks
Gustavo G. Fernandez Ranvier, Patrick Neshiwat, William B. Inabnet III

Central Neck Dissection: The Five Key Steps
Nathaniel J. Walsh, Asif M. Talukder, David J. Terris 

Transoral and Submental Thyroidectomy
Yufei Chen, Kathryn H. Chomsky-Higgins, Iheoma Nwaogu, Carolyn D. Seib, Jessica E. Gosnell, Wen T. Shen, Quan-Yang Duh, Insoo Suh 

Robotic Resection of an 8 mm Nonexophitic Pancreatic Insulinoma
Colleen M. Kiernan, Paula Marincola Smith, Zuliang Feng, Carmen C. Solórzano 

The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.

https://ift.tt/2zxc8Sa

Parapharyngeal Abscesses Caused by Group G Streptococcus

Deep neck abscess is a life-threatening infection that causes laryngeal edema and upper airway occlusion. The predominant bacterial species involved in this disorder is group A streptococcus. Group G streptococcus (GGS) constitutes the normal commensal flora of the human upper airway. Although rarely, it can cause pharyngitis, tonsillitis, and peritonsillar abscess. Here, we report a case of a woman with parapharyngeal abscess caused by GGS. A 56-year-old woman presented to the emergency department with complaints of sore throat and cervical swelling, and a diagnosis of parapharyngeal abscess was established. She had upper airway occlusion, requiring urgent tracheostomy. Endoscopic incision and drainage of the abscess using a specially designed, rigid curved laryngoscope was successfully performed. Since a rigid curved laryngoscope creates a wide viewing field and working space, it was useful for incision and drainage of the parapharyngeal abscess.

https://ift.tt/2Q9IAiY

Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan

Autosomal recessive congenital ichthyosis (ARCI) and ichthyosis syndrome (IS) are rare genetic skin disorders.

https://ift.tt/2xPqsDu

Follicular Involvement is Frequent in Lentigo Maligna: Implications for Treatment

Follicular involvement is a characteristic of lentigo maligna (LM) with unknown frequency. 95.8% of LM specimens demonstrated intrafollicular lesional melanocytes, with a mean depth of 0.45mm. When managing LM, follicular involvement should be assumed.

https://ift.tt/2zwuHFW

Laser-assisted photodynamic therapy for actinic keratosis: A systematic review and meta-analysis

This meta-analysis suggests that photodynamic therapy combined with ablative laser treatment for actinic keratosis is more efficient but not more painful than either therapy alone. Laser-assisted photodynamic therapy is an attractive option for patients with multiple actinic keratoses or field cancerization

https://ift.tt/2xPqjQs

Optimizing clinical images with a smartphone and light-emitting diode

https://ift.tt/2zxnNAe

Treatment of oral mucosal neuromas with carbon dioxide laser

https://ift.tt/2xPqafS

Camp Sun Safe: A community level sun safety intervention

https://ift.tt/2zxsw55

A Content Analysis of Local Media Framing of Intimate Partner Violence

Violence and Gender, Ahead of Print.


https://ift.tt/2OcUivN

A high number of IgG4-positive plasma cells rules out nodular lymphocyte predominant Hodgkin lymphoma

Abstract

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of Hodgkin lymphoma that frequently shows a nodal growth pattern with abundant reactive B cells in the microenvironment. Early NLPHL cases can be particularly difficult to differentiate from progressively transformed germinal centers (PTGC). Since PTGC have been described to be IgG4 associated in a relatively high proportion of cases, the aim of the present study was to determine if IgG4 immunostaining can be helpful in the differential diagnosis between NLPHL and PTGC. We furthermore aimed to learn if LP cells can express IgG4. For this purpose, 58 cases of PTGC and 56 cases of NLPHL were assessed using IgG4 immunostaining. We could confirm that a significant number of PTGC cases showed high numbers of IgG4-positive plasma cells (22/58, 38%), whereas hot spot areas of IgG4-positive plasma cells were not found in any of the NLPHL cases. In lymph node areas with the differential diagnosis of NLPHL and PTGC, IgG4 immunostaining can therefore provide a helpful diagnostic tool to rule out NLPHL when a high number of IgG4-positive plasma cells are encountered. We also assessed 13 cases with a combination of NLPHL and PTGC in the same lymph node. Five of these cases presented hot spot areas of IgG4-positive plasma cells in the PTGC regions, while no significant numbers of IgG4-positive plasma cells were observed in the NLPHL part of the lymph node. LP cells were never IgG4 positive. Furthermore, immunoglobulin heavy chain rearrangements of single IgG4-positive plasma cells were analyzed, revealing a polyclonal plasma cell population. In summary, our data suggest that IgG4 immunostaining can provide additional information in the diagnostic workup of cases with the differential diagnosis of NLPHL and PTGC. IgG4's inefficiency in clearing antigens may explain why lymph nodes with PTGC are usually strongly enlarged and develop a high number of hyperplastic germinal centers. Polyclonal immunoglobulin heavy chain rearrangements in IgG4-positive plasma cells further support the hypothesis that PTGC represent a misled immune reaction.

https://ift.tt/2IhUpAO

Miller Laryngoscope Blade: An Aid to Pediatric Laryngeal Surgery

Abstract

Pediatric upper airway disorders are a major cause of morbidity and mortality. They can be congenital or acquired and provide diagnostic and therapeutic challenge to the paediatrician and otolaryngologists. Though fibreoptic laryngoscopy or bronchoscopy is the initial mode of assessing the pathology, detailed assessment and therapeutic intervention can only be done combining both direct laryngoscopy and bronchoscopy. Any kind of intervention routinely requires rigid direct laryngoscope with suspension. Identifying the potential use of Miller laryngoscope blade for pediatric airway surgery is the aim of the study. We have included pediatric patients from new born to 12 years of age in our clinical study. We have been using Miller laryngoscope blade for approaching till the level of subglottis for diagnostic laryngoscopy along with Hopkins 0 degree endoscope and performing surgical procedures like supraglottoplasty, vallecular cysts, subglottic stenosis etc. Miller laryngoscope blade can be used as an aid to upper airway surgery for the otolaryngologists with minimal operating time and effort.

https://ift.tt/2N3Od0e

The micromass formation potential of human adipose-derived stromal cells isolated from different various origins

Abstract

Background

Adult stem cells appear to be a promising subject for tissue engineering, representing an individual material for regeneration of aged and damaged cells. Especially adipose derived stromal cells (ADSC), which are easily to achieve, allow an encouraging perspective due to their capability of differentiating into miscellaneous cell types. Here we describe the in vitro formation of human subcutaneous, visceral and omental ADSC micromasses and compare their histological attributes while being cultivated on collagen membranes.

Methods

Subcutaneous, visceral and omental fat tissue derived cells were isolated and processed according to standard protocols. Positively stained cells for CD13, CD44 and CD90 were cultivated on agarose in order to study micromass formation using a special method of cell tracking. Stained paraffin-embedded micromasses were analysed morphologically before and after being plated on collagen membranes.

Results

The micromass formation process was similar in all three tissue types. Subcutaneous fat tissue derived micromasses turned out to develop a more homogeneous and compact shape than visceral and omental tissue. Nevertheless all micromasses adhered to collagen membranes with visible spreading of cells. The immune histochemical (IHC) staining of subcutaneous, visceral and omental ADSC micromasses shows a constant expression of CD13 and a decrease of CD44 and CD 90 expression within 28 days. After that period, omental fat cells don't show any expression of CD44.

Conclusion

In conclusion micromass formation and cultivation of all analysed fat tissues can be achieved, subcutaneous cells appearing to be the best material for regenerative concepts.

https://ift.tt/2N6a8Uu

Miller Laryngoscope Blade: An Aid to Pediatric Laryngeal Surgery

Abstract

Pediatric upper airway disorders are a major cause of morbidity and mortality. They can be congenital or acquired and provide diagnostic and therapeutic challenge to the paediatrician and otolaryngologists. Though fibreoptic laryngoscopy or bronchoscopy is the initial mode of assessing the pathology, detailed assessment and therapeutic intervention can only be done combining both direct laryngoscopy and bronchoscopy. Any kind of intervention routinely requires rigid direct laryngoscope with suspension. Identifying the potential use of Miller laryngoscope blade for pediatric airway surgery is the aim of the study. We have included pediatric patients from new born to 12 years of age in our clinical study. We have been using Miller laryngoscope blade for approaching till the level of subglottis for diagnostic laryngoscopy along with Hopkins 0 degree endoscope and performing surgical procedures like supraglottoplasty, vallecular cysts, subglottic stenosis etc. Miller laryngoscope blade can be used as an aid to upper airway surgery for the otolaryngologists with minimal operating time and effort.

https://ift.tt/2N3Od0e

Juvenile Spring Eruption Associated With Parvovirus B19 Infection

This case report describes the occurrence of juvenile spring eruption associated with parvovirus B19 infection.

https://ift.tt/2O9toVN

Multispectral Optoacoustic Tomography for Vascular Malformations

This pilot study evaluates the use of multispectral optoacoustic tomography for assessment of biomarkers among patients with arteriovenous and venous malformation.

https://ift.tt/2OVXgCh

Identifying Disparities in Dermatology

https://ift.tt/2Od1Y18

Differences in Use of Outpatient Dermatology Services in the United States

This study examines nationwide differences in demographic and socioeconomic characteristics and use of outpatient dermatologic care among Medical Expenditure Panel Survey respondents.

https://ift.tt/2Qahet3

Vasculitis

This Patient Page describes vasculitis, focusing especially on skin vasculitis, how to recognize it, and how it might be treated.

https://ift.tt/2OP4nfG

Spontaneous asymptomatic rupture of pseudocyst into stomach

Description 

A 27-year-old woman presented with complaints of pain in the epigastric region radiating to back for 20 days. She was treated initially at local hospital and was diagnosed as acute pancreatitis as her amylase and lipase levels were >1000 U/mL. She was managed with analgesics and intravenous fluids and was discharged in 4 days. She then presented to our emergency, with complaints of epigastric pain, awareness of lump in the epigastric region and non-passage of stool or flatus for past 3 days. She also gave history of fever and multiple episodes of bilious vomiting. Patient denied previous history of similar episodes in past and is non-alcoholic. On abdominal examination, a lump of size 20x15 cm was palpable in the epigastric region extending into the umbilical region. On ultrasonogram abdomen, a cystic swelling was seen along with multiple gall stones in the gall bladder. Contrast-enhanced CT (CECT) abdomen was suggestive of a large cystic...

https://ift.tt/2IntjIR

Primary retroperitoneal filariasis: a common disease of tropics with uncommon presentation and review of literature

Lymphatic filariasis is caused by nematode filariae Wuchereria bancrofti, Brugia malayi or Brugia timori. It is commonly seen in tropical and subtropical regions of the world and affects the lymphatic system of humans, who are the definitive host while mosquito is the intermediate host. The most common manifestation of the disease is hydrocele followed by lower limb lymphoedema and elephantiasis. Although filariasis is much more common entity in north India, its presentation as retroperitoneal cyst is very rare with reported incidence rate of 1/105 000. We present a case of primary retroperitoneal filariasis in a 52-year-old man, without any classic signsandsymptoms, diagnosed postoperatively after surgical resection following diagnostic uncertaintyandfailure of other medical therapies.

https://ift.tt/2OfbCjV

Gossypiboma: a ghastly find

A gossypiboma is a mass within a patient's body comprising a cotton matrix surrounded by a foreign body granuloma. We describe an unusual presentation of a gossypiboma presenting in a 32-year-old man with acute epigastric pain and haematemesis. His surgical history revealed an emergency laparotomy following a road traffic accident 16 years ago. Initial gastroscopy showed extrinsic stomach compression. An abdominal ultrasound scan followed by a CT scan evidenced a large, well-defined, predominantly cystic mass with some solid areas occupying the left hypochondrium. Conservative management with insertion of a percutaneous drain proved to be inefficient. A laparotomy was performed; intraoperatively, the cyst was found to be ruptured and within it, a large surgical gauze was found. This was removed but required a distal pancreatectomy and gastrectomy for complete excision. He was discharged on day 74 of admission with outpatient follow-up.

https://ift.tt/2Ih30Us

Primary renal diffuse large B-Cell lymphoma causing haemodialysis-dependent nephromegaly in a child

A 4-year-old boy presented with fatigue and was found to have severe kidney injury requiring haemodialysis. A renal ultrasound demonstrated bilateral nephromegaly with mild loss of corticomedullary differentiation but preserved echogenicity. He had a persistent isolated monocytosis. Renal biopsy revealed extensive infiltration by primary renal diffuse large B-cell lymphoma. He required haemodialysis for 18 days and received chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisone, rituximab and intrathecal methotrexate. He achieved remission with an estimated glomerular filtration rate of 50 mL/min/1.73 m², and his kidneys returned to normal size. Nephromegaly due to renal-limited haematolymphoid disease is extremely rare, especially in children.

https://ift.tt/2ObiE9s

Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2zvZ2oe

Effects of language background on the development of sociolinguistic awareness: the perception of accent variation in monolingual and multilingual 5-7 year old children

Evans, BG; Tomé Lourido, G; (2018) Effects of language background on the development of sociolinguistic awareness: the perception of accent variation in monolingual and multilingual 5-7 year old children. Phonetica (In press).

https://ift.tt/2R5P2Jc

Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media

Munro, PRT; (2018) Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media. Journal of Biomedical Optics , 23 (9) , Article 090801. 10.1117/1.JBO.23.9.090801 . Green open access

https://ift.tt/2QahjwO

Uptake of the English Bowel (Colorectal) Cancer Screening Programme: an update 5 years after the full roll-out

Hirst, Y; Stoffel, S; Baio, G; McGregor, L; von Wagner, C; (2018) Uptake of the English Bowel (Colorectal) Cancer Screening Programme: an update 5 years after the full roll-out. European Journal of Cancer 10.1016/j.ejca.2018.07.135 . (In press). Green open access

https://ift.tt/2QYx37j

Genetic evidence for a western Chinese origin of broomcorn millet (Panicum miliaceum)

Hunt, HV; Rudzinski, A; Jiang, H; Wang, R; Thomas, MG; Jones, MK; (2018) Genetic evidence for a western Chinese origin of broomcorn millet (Panicum miliaceum). The Holocene 0959683618798116. 10.1177/0959683618798116 . (In press). Green open access

https://ift.tt/2Q3HZz6

White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation

Teunissen, CE; Otto, M; Engelborghs, S; Herukka, S-K; Lehmann, S; Lewczuk, P; Lleó, A; ... Blennow, K; + view all Teunissen, CE; Otto, M; Engelborghs, S; Herukka, S-K; Lehmann, S; Lewczuk, P; Lleó, A; Perret-Liaudet, A; Tumani, H; Turner, MR; Verbeek, MM; Wiltfang, J; Zetterberg, H; Parnetti, L; Blennow, K; - view fewer (2018) White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation. Alzheimer's Research & Therapy , 10 (1) , Article 30. 10.1186/s13195-018-0359-x . Green open access

https://ift.tt/2R0iOyW

Treatment for hepatorenal syndrome in people with decompensated liver cirrhosis: A network meta-analysis

Best, LMJ; Freeman, S; Sutton, AJ; Hawkins, N; Tsochatzis, E; Gurusamy, KS; (2018) Treatment for hepatorenal syndrome in people with decompensated liver cirrhosis: A network meta-analysis. Cochrane Database of Systematic Reviews , 2018 (9) 10.1002/14651858.CD013103 .

https://ift.tt/2Q7WdPO

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship

Petersone, L; Edner, NM; Ovcinnikovs, V; Heuts, F; Ross, EM; Ntavli, E; Wang, CJ; Petersone, L; Edner, NM; Ovcinnikovs, V; Heuts, F; Ross, EM; Ntavli, E; Wang, CJ; Walker, LSK; - view fewer (2018) T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship. [Review]. Frontiers in Immunology , 9 , Article 1941. 10.3389/fimmu.2018.01941 . Green open access

https://ift.tt/2R2SPXo

Simulation and Optimization for Railway Operations Management

D'Ariano, A; Corman, F; Fujiyama, T; Meng, L; Pellegrini, P; (2018) Simulation and Optimization for Railway Operations Management. Journal of Advanced Transportation , 2018 , Article 4896748. 10.1155/2018/4896748 . Green open access

https://ift.tt/2Q9UYzv

An experiential observational study of graduates from the Japanese six year programme

Takeda Mamiya, Kayoko; akahashi, kiyoshi; Bates, I; Kurosowa, Nahoko; Hirata, Kazumasa; Satoh, Hideki; Shimamori, Yoshimitshu; (2018) An experiential observational study of graduates from the Japanese six year programme. Pharmacy Education (In press).

https://ift.tt/2R0Irzp

The ‘Better Conversations with Primary Progressive Aphasia (BCPPA)’ program for people with PPA (Primary Progressive Aphasia): Protocol for a randomised controlled pilot study

Volkmer, ALP; Spector, A; Warren, J; Beeke, S; (2018) The 'Better Conversations with Primary Progressive Aphasia (BCPPA)' program for people with PPA (Primary Progressive Aphasia): Protocol for a randomised controlled pilot study. Pilot and Feasibility Studies (In press). Green open access

https://ift.tt/2Q83T4o

Integration of spatial information in convolutional neural networks for automatic segmentation of intraoperative transrectal ultrasound images

Ghavami, N; Hu, Y; Bonmati, E; Rodell, R; Gibson, E; Moore, C; Barratt, D; (2018) Integration of spatial information in convolutional neural networks for automatic segmentation of intraoperative transrectal ultrasound images. Journal of Medical Imaging , 6 (1) , Article 011003. 10.1117/1.JMI.6.1.011003 . Green open access

https://ift.tt/2R0r3ef

Crossing the digital divide in online self-management support: analysis of usage data from HeLP-Diabetes

Poduval, S; ahmed, S; Marston, L; Hamilton, F; Murray, E; (2019) Crossing the digital divide in online self-management support: analysis of usage data from HeLP-Diabetes. JMIR Diabetes 10.2196/10925 . (In press).

https://ift.tt/2Q8RRro

Exploring cosmic origins with CORE: Effects of observer peculiar motion

Burigana, C; Carvalho, CS; Trombetti, T; Notari, A; Quartin, M; Gasperis, GD; Buzzelli, A; ... Zannoni, M; + view all Burigana, C; Carvalho, CS; Trombetti, T; Notari, A; Quartin, M; Gasperis, GD; Buzzelli, A; Vittorio, N; De Zotti, G; de Bernardis, P; Chluba, J; Bilicki, M; Danese, L; Delabrouille, J; Toffolatti, L; Lapi, A; Negrello, M; Mazzotta, P; Scott, D; Contreras, D; Achucarro, A; Ade, P; Allison, R; Ashdown, M; Ballardini, M; Banday, AJ; Banerji, R; Bartlett, J; Bartolo, N; Basak, S; Bersanelli, M; Bonaldi, A; Bonato, M; Borrill, J; Bouchet, F; Boulanger, F; Brinckmann, T; Bucher, M; Cabella, P; Cai, Z-Y; Calvo, M; Castellano, MG; Challinor, A; Clesse, S; Colantoni, I; Coppolecchia, A; Crook, M; D'Alessandro, G; Diego, J-M; Di Marco, A; Di Valentino, E; Errard, J; Feeney, S; Fernandez-Cobos, R; Ferraro, S; Finelli, F; Forastieri, F; Galli, S; Genova-Santos, R; Gerbino, M; Gonzalez-Nuevo, J; Grandis, S; Greenslade, J; Hagstotz, S; Hanany, S; Handley, W; Hernandez-Monteagudo, C; Hervias-Caimapo, C; Hills, M; Hivon, E; Kiiveri, K; Kisner, T; Kitching, T; Kunz, M; Kurki-Suonio, H; Lamagna, L; Lasenby, A; Lattanzi, M; Lesgourgues, J; Liguori, M; Lindholm, V; Lopez-Caniego, M; Luzziio, G; Maffei, B; Mandolesi, N; Martinez-Gonzalez, E; Martins, CJAP; Masi, S; Matarrese, S; McCarthy, D; Melchiorri, A; Melin, J-B; Molinari, D; Monfardini, A; Natoli, P; Paiellam, A; Paoletti, D; Patanchon, G; Piat, M; Pisano, G; Polastri, L; Polenta, G; Pollo, A; Poulin, V; Remazeilles, M; Roman, M; Rubino-Martin, J-A; Salvati, L; Tartari, A; Tomasi, M; Tramonte, D; Trappe, N; Tucker, C; Valiviita, J; Van de Weijgaert, R; van Tent, B; Vennin, V; Vielva, P; Young, K; Zannoni, M; - view fewer (2018) Exploring cosmic origins with CORE: Effects of observer peculiar motion. Journal of Cosmology and Astroparticle Physics , 2018 (4) , Article 021. 10.1088/1475-7516/2018/04/021 .

https://ift.tt/2R1p8Gy

Plasma AR and docetaxel for metastatic castration-resistant prostate cancer

Attard, G; Conteduca, V; Jayaram, A; Romero-Laorden, N; Wetterskog, D; Salvi, S; Gurioli, G; ... de Giorgi, U; + view all Attard, G; Conteduca, V; Jayaram, A; Romero-Laorden, N; Wetterskog, D; Salvi, S; Gurioli, G; Scarpi, E; Castro, E; Marin-Aguilera, M; Lolli, C; Schepisi, G; Maugeri, A; Wingate, A; Farolfi, A; Casadio, V; Medina, A; Puente, J; Méndez Vidal, MJ; Morales-Barrera, R; Villa-Guzmán, JC; Hernando, S; Rodriguez-Vida, A; González-del-Alba, A; Mellado, B; Gonzalez-Billalabeitia, E; Olmos, D; de Giorgi, U; - view fewer (2018) Plasma AR and docetaxel for metastatic castration-resistant prostate cancer. European Urology (In press).

https://ift.tt/2Q83LSs

Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: A network meta-analysis

Gurusamy, KS; Wilson, P; Tsochatzis, E; (2018) Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: A network meta-analysis. Cochrane Database of Systematic Reviews , 2018 (9) 10.1002/14651858.CD013120 .

https://ift.tt/2QVqhiC

Exploring cosmic origins with CORE: B-mode component separation

Remazeilles, M; Banday, AJ; Baccigalupi, C; Basak, S; Bonaldi, A; De Zotti, G; Delabrouille, J; ... Zannoni, M; + view all Remazeilles, M; Banday, AJ; Baccigalupi, C; Basak, S; Bonaldi, A; De Zotti, G; Delabrouille, J; Dickinson, C; Eriksen, HK; Errard, J; Fernandez-Cobos, R; Fuskeland, U; Hervias-Caimapo, C; Lopez-Caniego, M; Martinez-Gonzalez, E; Roman, M; Vielva, P; Wehus, I; Achucarro, A; Ade, P; Allison, R; Ashdown, M; Ballardini, M; Banerji, R; Bartlett, J; Bartolo, N; Baumann, D; Bersanelli, M; Bonato, M; Borrill, J; Bouchet, F; Boulanger, F; Brinckmann, T; Bucher, M; Burigana, C; Buzzelli, A; Cai, Z-Y; Calvo, M; Carvalho, C-S; Castellano, G; Challinor, A; Chluba, J; Clesse, S; Colantoni, I; Coppolecchia, A; Crook, M; D'Alessandro, G; de Bernardis, P; de Gasperis, G; Diego, J-M; Di Valentino, E; Feeney, S; Ferraro, S; Finelli, F; Forastieri, F; Galli, S; Genova-Santos, R; Gerbino, M; Gonzalez-Nuevo, J; Grandis, S; Greenslade, J; Hagstotz, S; Hanany, S; Handley, W; Hernandez-Monteagudo, C; Hills, M; Hivon, E; Kiiveri, K; Kisner, T; Kitching, T; Kunz, M; Kurki-Suonio, H; Lamagna, L; Lasenby, A; Lattanzi, M; Lesgourgues, J; Lewis, A; Liguori, M; Lindholm, V; Luzzi, G; Maffei, B; Martins, CJAP; Masi, S; Matarrese, S; McCarthy, D; Melin, J-B; Melchiorri, A; Molinari, D; Monfardini, A; Natoli, P; Negrello, M; Notari, A; Paiella, A; Paoletti, D; Patanchon, G; Piat, M; Pisano, G; Polastri, L; Polenta, G; Pollo, A; Poulin, V; Quartin, M; Rubino-Martin, J-A; Salvati, L; Tartari, A; Tomasi, M; Tramonte, D; Trappe, N; Trombetti, T; Tucker, C; Valiviita, J; Van de Weijgaert, R; van Tent, B; Vennin, V; Vittorio, N; Young, K; Zannoni, M; - view fewer (2018) Exploring cosmic origins with CORE: B-mode component separation. Journal of Cosmology and Astroparticle Physics , 2018 (4) , Article 023. 10.1088/1475-7516/2018/04/023 .

https://ift.tt/2Q83oaw

Primary prevention of bleeding in people with oesophageal varices due to liver cirrhosis: A network meta-analysis

Gurusamy, KS; Tsochatzis, E; (2018) Primary prevention of bleeding in people with oesophageal varices due to liver cirrhosis: A network meta-analysis. Cochrane Database of Systematic Reviews , 2018 (9) 10.1002/14651858.CD013121 .

https://ift.tt/2R1oCbA

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

Shorrock, H; van der Hoorn, D; Boyd, P; Hurtado, M; Lamont, D; Wirth, B; Sleigh, JN; ... Gillingwater, TH; + view all Shorrock, H; van der Hoorn, D; Boyd, P; Hurtado, M; Lamont, D; Wirth, B; Sleigh, JN; Schiavo, G; Wishart, T; Groen, EJN; Gillingwater, TH; - view fewer (2018) UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Brain: A Journal of Neurology 10.1093/brain/awy237 . (In press). Green open access

https://ift.tt/2QabsHF

Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with Cediranib plus Placebo in Subjects with Recurrent/Progressive Glioblastoma

Brown, N; McBain, C; Nash, S; Hopkins, K; Sanghera, P; Saran, F; Phillips, M; ... Mulholland, P; + view all Brown, N; McBain, C; Nash, S; Hopkins, K; Sanghera, P; Saran, F; Phillips, M; Dungey, F; Clifton-Hadley, L; Wanek, K; Krell, D; Jeffries, S; Khan, I; Smith, P; Mulholland, P; - view fewer (2016) Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with Cediranib plus Placebo in Subjects with Recurrent/Progressive Glioblastoma. PLoS ONE , 11 (5) 10.1371/journal.pone.0156369 . Green open access

https://ift.tt/2QYM1tU

Changing state of Arctic sea ice across all seasons

Stroeve, J; Notz, D; (2018) Changing state of Arctic sea ice across all seasons. Environmental Research Letters , 13 (10) , Article 103001. 10.1088/1748-9326/aade56 . Green open access

https://ift.tt/2Q83ija

MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene

Abstract

Salivary duct carcinomas (SDC) and Her2/Neu3-overexpressing invasive breast carcinomas (HNPIBC/IBC) are histologically indistinguishable. We investigated whether common histopathologic and immunophenotypic features of SDC and IBC are mirrored by a similar microRNA (miRNA) profile. MiRNA profiling of 5 SDCs, 6 IBCs Her2/Neu3+, and 5 high-grade ductal breast carcinoma in situ (DCIS) was performed by NanoString platform. Selected miRNAs and HOXA1 gene were validated by RT-PCR. We observed similar miRNA expression profiles between IBC and SDC with the exception of 2 miRNAs, miR-10a and miR-142-3p, which were higher in IBC tumors. DCIS tumors displayed increased expression of miR-10a, miR-99a, miR-331-3p and miR-335, and decreased expression of miR-15a, miR-16 and miR-19b compared to SDC. The normal salivary gland and breast tissues also showed similar expression profiles. Interestingly, miR-10a was selectively increased in both IBC and normal breast tissue compared to SDC and normal salivary gland tissue. Moreover, our NanoString and RT-PCR data confirmed that miR-10a was upregulated in IBC and DCIS compared to SDC. Finally, we show downregulation of HOXA1, a miR-10 target, in IBC tumors compared to normal breast tissue. Taken together, our data demonstrates that, based on miRNA profiling, SDC is closely related to HNPIBC. Our results also suggest that miR-10a is differentially expressed in IBC compared to SDC and may have potential utility as a diagnostic biomarker in synchronous or metachronous malignant epithelial malignancies involving both organs. In addition, miR-10a could be playing an important role as a mammary-specific oncogene, involved in breast cancer initiation (DCIS) and progression (IBC), through mechanisms that include modulation of HOXA1 gene expression.

https://ift.tt/2ObyCjF

Comparison between curettage adenoidectomy and endoscopic-assisted microdebrider adenoidectomy in terms of Eustachian tube dysfunction

Publication date: Available online 25 September 2018

Source: Brazilian Journal of Otorhinolaryngology

Author(s): Mahmut Huntürk Atilla, Selda Kargın Kaytez, Gülin Gökçen Kesici, Sibel Baştimur, Sebahattin Tuncer

Abstract

Introduction

Adenoidectomy can be performed with many ways, including curettage and microdebrider endoscopic-assisted adenoidectomy. Those two techniques have advantages and disadvantages.

Objective

The objective of this study is to research the effects of curettage adenoidectomy and endoscopic-assisted microdebrider adenoidectomy on the tympanum pressures in pediatric patients with adenoid hypertrophy without otitis media with effusion.

Methods

This prospective descriptive study was performed with 65 patients who had a normal tympanic membrane and normal tympanogram and then underwent adenoidectomy or adenotonsillectomy for adenoid and tonsil hypertrophy. The subjects were randomly divided into two groups: curettage adenoidectomy group and endoscopic microdebrider-assisted adenoidectomy group. They underwent tympanometry, and the preoperative as well as 1st and 7th day postoperative values of the tympanum pressures were compared within and among the groups.

Results

There were 32 patients in the curettage adenoidectomy group and 33 patients in the microdebrider adenoidectomy group. Statistically significant differences were observed in the median tympanum pressure on the preoperative and 1st and 7th postoperative days for both the left and right ears with curettage adenoidectomy (p < 0.001, p < 0.001). This difference occurred on the 1st postoperative day, and the value returned to normal on the 7th day. There was no significant difference in the median tympanum pressure on the preoperative and 1st and 7th postoperative days for both the left and right ears in the microdebrider adenoidectomy group (p = 0.376, p = 0.128).

Conclusion

Postoperative Eustachian tube dysfunction is seen less often with the endoscopic-assisted microdebrider adenoidectomy technique than with the conventional adenoidectomy technique.

Resumo

Introdução

A adenoidectomia pode ser realizada de várias maneiras, incluindo a adenoidectomia por curetagem e por microdebridador, assistida por endoscopia. Essas duas técnicas têm algumas vantagens e desvantagens quando comparadas.

Objetivo

O objetivo deste estudo é investigar os efeitos da técnica de adenoidectomia por curetagem e da adenoidectomia por microdebridador assistida por endoscopia sobre a pressão timpânica em pacientes pediátricos com hipertrofia adenoideana sem otite média com efusão.

Método

Este estudo descritivo prospectivo foi realizado com 65 pacientes que apresentavam membrana timpânica e timpanograma normais, que foram então submetidos à adenoidectomia ou adenotonsilectomia por hipertrofia adenoamigdaliana. Os pacientes foram divididos aleatoriamente em dois grupos: grupo adenoidectomia por curetagem e grupo adenoidectomia por microdebridador assistida por endoscópio. Todo os pacientes realizaram timpanometria, e os valores das pressões do tímpano pré-operatórios e pós-operatórios no 1° e 7° dias foram comparados intragrupos e entre os grupos.

Resultados

Foram incluídos 32 pacientes no grupo adenoidectomia por curetagem e 33 pacientes no grupo adenoidectomia com microdebridador. Diferenças estatisticamente significativas foram observadas na mediana da diferença entre a pressão timpânica no pré-operatório e no 1° e 7° dias de pós-operatório para ambas as orelhas, direita e esquerda, na adenoidectomia por curetagem (p < 0,001, p < 0,001). Essa diferença ocorreu no 1° dia do pós-operatório e o valor retornou ao normal no 7° dia. Não houve diferença significativa na mediana entre pressão timpânica no pré-operatório e no 1° e 7° dias de pós-operatório para as orelhas direita e esquerda no grupo de adenoidectomia com microdebridador (p = 0,376, p = 0,128).

Conclusão

A disfunção tubária no pós-operatório é observada menos frequentemente com a técnica de adenoidectomia por microdebridador assistida por endoscopia quando comparada com a técnica de adenoidectomia convencional.

https://ift.tt/2Q7MXuG

MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene

Abstract

Salivary duct carcinomas (SDC) and Her2/Neu3-overexpressing invasive breast carcinomas (HNPIBC/IBC) are histologically indistinguishable. We investigated whether common histopathologic and immunophenotypic features of SDC and IBC are mirrored by a similar microRNA (miRNA) profile. MiRNA profiling of 5 SDCs, 6 IBCs Her2/Neu3+, and 5 high-grade ductal breast carcinoma in situ (DCIS) was performed by NanoString platform. Selected miRNAs and HOXA1 gene were validated by RT-PCR. We observed similar miRNA expression profiles between IBC and SDC with the exception of 2 miRNAs, miR-10a and miR-142-3p, which were higher in IBC tumors. DCIS tumors displayed increased expression of miR-10a, miR-99a, miR-331-3p and miR-335, and decreased expression of miR-15a, miR-16 and miR-19b compared to SDC. The normal salivary gland and breast tissues also showed similar expression profiles. Interestingly, miR-10a was selectively increased in both IBC and normal breast tissue compared to SDC and normal salivary gland tissue. Moreover, our NanoString and RT-PCR data confirmed that miR-10a was upregulated in IBC and DCIS compared to SDC. Finally, we show downregulation of HOXA1, a miR-10 target, in IBC tumors compared to normal breast tissue. Taken together, our data demonstrates that, based on miRNA profiling, SDC is closely related to HNPIBC. Our results also suggest that miR-10a is differentially expressed in IBC compared to SDC and may have potential utility as a diagnostic biomarker in synchronous or metachronous malignant epithelial malignancies involving both organs. In addition, miR-10a could be playing an important role as a mammary-specific oncogene, involved in breast cancer initiation (DCIS) and progression (IBC), through mechanisms that include modulation of HOXA1 gene expression.

https://ift.tt/2ObyCjF

Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions

Condition:   Oral Cancer
Interventions:   Drug: Metformin Hcl 500Mg 24Hr Sa Tab;   Other: starch tablet
Sponsor:   Ain Shams University
Recruiting

https://ift.tt/2ORkqcQ

Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)

Condition:   Oral Potentially Malignant Leions, Oral Cancer
Intervention:   Diagnostic Test: Enzyme Linked Immunosorbent assay (ELISA)
Sponsor:   Cairo University
Not yet recruiting

https://ift.tt/2R0ANoL

A Phase 1b/2 Study of AST-008 Combined With Pembrolizumab in Patients With Advanced Solid Tumors

Conditions:   Advanced or Metastatic Solid Tumors;   Advanced or Metastatic Melanoma;   Advanced or Metastatic Head and Neck Squamous Cell Carcinoma;   Advanced or Metastatic Cutaneous Squamous Cell Carcinoma;   Advanced or Metastatic Merkel Cell Carcinoma
Interventions:   Drug: AST-008;   Biological: Pembrolizumab
Sponsor:   Exicure, Inc.
Not yet recruiting

https://ift.tt/2ORkeu8

CoreHip - Post Market Clinical Follow-Up Study

Conditions:   Degenerative Osteoarthritis;   Rheumatic Arthritis;   Fractures, Hip;   Necrosis, Femur Head
Intervention:   Device: CoreHip Total Hip Arthroplasty
Sponsor:   Aesculap AG
Not yet recruiting

https://ift.tt/2QXgLeW

Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions

Condition:   Oral Cancer
Interventions:   Drug: Metformin Hydrochloride 500 MG;   Drug: Placebo Oral Tablet
Sponsor:   Cairo University
Recruiting

https://ift.tt/2ORk71G

The Epidemiology of Hepatitis D Virus in North Africa: A Systematic Review and Meta-Analysis

Background. Hepatitis D virus (HDV) infection has been considered a serious neglected pandemic, particularly in developing countries. The virus causes a more severe disease than mono infection with hepatitis B virus (HBV). The epidemiology of HDV is not well documented in North Africa, which is known to be endemic for HBV. In this study, we explored the prevalence of HDV infection and also attempted to identify factors associated with hepatitis D positive status among chronic hepatitis B patients in North Africa. Methods. The electronic databases PubMed, Embase, Scopus, Science Direct, Web of Science, and Google Scholar were comprehensively searched for all papers published between January 1, 1998, and December 31, 2017, using appropriate strategies containing all related keywords, including North Africa, names of countries in the region, and all permutations of hepatitis D virus. The estimated prevalence of HDV in North Africa was calculated as an average of the pooled infection prevalence in each country weighted by the ratio of the country's hepatitis D virus population to the study's sample size in the survey data analysis. Findings. A total of 312 studies were identified and 32 were included in this study, with a total sample of 4907 individuals screened for HDV. There was considerable variability in the prevalence estimates of HDV within the countries of the region. The overall prevalence of HDV in the general population of North Africa was 5·01% (95% CI: 1·25–8·27) and in liver disease patients it was 20.7% (95% CI:9.87–44.53). Genotype-1 was the most prominent genotype reported in five published studies. Ten studies reported on HDV RNA in participants who were seropositive for HDV, and four studies highlighted the impact of demographic factors (sex and age). No study showed the impact of risk factors on the prevalence of HDV in North Africa. Interpretation. This review provides a comprehensive assessment of the burden of HDV in Northern Africa. There were significant differences in seroprevalence, study population, and diagnostic testing between the countries in the region. The results presented here will alert health professionals to implement clear policies based on evidence to diminish the burden of HDV infection. Such measures may include but are not restricted to improving the laboratory diagnostic tests and initiating patient data registries and blood screening. Further epidemiological and research studies are needed to explore the risk factors, coinfections, and approaches to increase testing for HDV, particularly in high-risk subpopulations, such as intravenous drug users and immigrants, and to define the consequences of HDV infection in North Africa.

https://ift.tt/2QYhwo1

MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene

Abstract

Salivary duct carcinomas (SDC) and Her2/Neu3-overexpressing invasive breast carcinomas (HNPIBC/IBC) are histologically indistinguishable. We investigated whether common histopathologic and immunophenotypic features of SDC and IBC are mirrored by a similar microRNA (miRNA) profile. MiRNA profiling of 5 SDCs, 6 IBCs Her2/Neu3+, and 5 high-grade ductal breast carcinoma in situ (DCIS) was performed by NanoString platform. Selected miRNAs and HOXA1 gene were validated by RT-PCR. We observed similar miRNA expression profiles between IBC and SDC with the exception of 2 miRNAs, miR-10a and miR-142-3p, which were higher in IBC tumors. DCIS tumors displayed increased expression of miR-10a, miR-99a, miR-331-3p and miR-335, and decreased expression of miR-15a, miR-16 and miR-19b compared to SDC. The normal salivary gland and breast tissues also showed similar expression profiles. Interestingly, miR-10a was selectively increased in both IBC and normal breast tissue compared to SDC and normal salivary gland tissue. Moreover, our NanoString and RT-PCR data confirmed that miR-10a was upregulated in IBC and DCIS compared to SDC. Finally, we show downregulation of HOXA1, a miR-10 target, in IBC tumors compared to normal breast tissue. Taken together, our data demonstrates that, based on miRNA profiling, SDC is closely related to HNPIBC. Our results also suggest that miR-10a is differentially expressed in IBC compared to SDC and may have potential utility as a diagnostic biomarker in synchronous or metachronous malignant epithelial malignancies involving both organs. In addition, miR-10a could be playing an important role as a mammary-specific oncogene, involved in breast cancer initiation (DCIS) and progression (IBC), through mechanisms that include modulation of HOXA1 gene expression.

https://ift.tt/2ObyCjF

Regulation of systemic tissue injury by coagulation inhibitors in B6.MRL/lpr autoimmune mice

Publication date: Available online 25 September 2018

Source: Clinical Immunology

Author(s): C. Moratz, R. Robbins, J. Eickhoff, J. Edison, H. Lui, S. Peng

Abstract

Impaired fibrinolysis and complement activation in Systemic Lupus Erythematosus contributes to disease amplification including increased risk of thrombosis and tissue Ischemia/Reperfusion (IR) injury. Previous work has demonstrated complement is a key regulator of tissue injury. In these studies inhibitors had varying efficacies in attenuating injury at primary versus systemic sites, such as lung. In this study the role of coagulation factors in tissue injury and complement function was evaluated. Tissue Factor Pathway Inhibitor (TFPI), an extrinsic pathway inhibitor, and Anti-Thrombin III, the downstream common pathway inhibitor, were utilized in this study. TFPI was more effective in attenuated primary intestinal tissue injury. However both attenuated systemic lung injury. However, ATIII treatment resulting in enhanced degradation of C3 split products in lung tissue compared to TFPI. This work delineates the influence of specific early and late coagulation pathway components during initial tissue injury versus later distal systemic tissue injury mechanism.

https://ift.tt/2xTPJfG

Intérêt du dosage de la calprotectine fécale au cours des panniculites chroniques d’étiologie indéterminée

Publication date: Available online 25 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): K. Kaddour, J. Lemasson, B. Haettich-Pialoux, N. Guedj, N. Belmatoug, X. Treton, H. Becheur, B. Fantin, V. Descamps, P. Le Bozec

https://ift.tt/2OdePk1

Langzeitfolgen onkologischer Behandlungen

https://ift.tt/2N15Gq9

Treatment of Objective Tinnitus with Transpalatal Botox® Injection in a Pediatric Patient with Middle Ear Myoclonus: A case report

Publication date: Available online 25 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Jennifer Dang, Yi-Chun Carol Liu

Abstract

We describe a case of bilateral middle ear myoclonus (MEM) that was treated with trans-palatal Botox® injection after failing surgery to section the tensor tympani and stapedial tendons. MEM is a rare disorder resulting from rhythmic contraction of middle ear muscles. An 8-year old girl presented with audible clicking tinnitus, and resultant inability to focus in school. Her parents declined medical therapy, and she underwent surgeries for tendon lysis, with only temporary relief. She had successful response to trans-palatal Botox® injection to the tensor veli palatini aponeurosis. Trans-palatal Botox® injection is a safe and reasonable alternative for treatment of MEM.

https://ift.tt/2IhT1hC

Tracheostomy Care: Clinical practice patterns of pediatric otolaryngologists-head and neck surgeons in a publicly funded (Canadian) health care system

Publication date: Available online 25 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Sunita K. Rai, Theresa Holler, Evan J. Propst, Nikolaus E. Wolter, Reshma Amin

Abstract

Objectives

To investigate variability in paediatric tracheostomy tube care practice patterns and access to resources across Canada.

Methods

Canadian paediatric otolaryngologists-head & neck surgeons reported their own practice patterns for children with chronic tracheostomy tubes using a web-based, 29-item multiple choice and short answer questionnaire. Domains investigated included tracheostomy team membership, inpatient care practices, caregiver education, homecare resources, speech and communication, and completeness of emergency tracheostomy kits.

Results

The response rate was 86.4% (38/44). Most respondents care for children with tracheostomy tubes as part of an inter-professional team (25/36; 69.4%) and arrange routine follow-up with a speech and language pathologist (22/36; 61.1%). However, the majority (23/34; 67.6%) of respondents do not formally reassess caregiver competencies (i.e. cardiopulmonary resuscitation, emergency tracheostomy care). Notably, respondents were also unsure 36.1% (13/36) of how frequently Shiley tracheostomy tubes should be washed and reused with the majority (15/36; 41.7%) reporting never. Most (15/36; 41.7%) respondents were also unsure of reuse recommendations for Bivona tracheostomy tubes. One third (12/36; 33.3%) of respondents were unsure about government-funded homecare services being provided in their community to children with tracheostomy tubes.

Conclusion

There is much variability in paediatric tracheostomy tube care practice patterns across Canada. Results suggest that an evidence-based Canadian clinical practice guideline may help to streamline care provided to Canadian children with tracheostomy tubes.

https://ift.tt/2QZjc0s

Outcomes of Early Intervention for Deaf Children with Additional Needs following an Auditory Verbal Approach to Communication

Publication date: Available online 25 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Abigail.R.C. Hitchins, Sarah.C. Hogan

Abstract

Objectives

To determine and compare the rates of progress made by pre-school aged children with all degrees and types of hearing impairment and deafness, both with and without additional needs as catalogued using SNOMED CT, at the end of a non-statutory programme of individualised Auditory Verbal (AV) intervention.

Methods

An audit was conducted using a retrospective and comparative study design to examine spoken language outcomes in children who had spent more than two years on an AV programme and had completed their programmes between January 2007 and December 2017. The children were stratified according to i) whether they achieved age appropriate language (AAL) (n =102) or not (n =27); ii) whether they had deafness alone (n = 77) or deafness with additional needs (n =52); and iii) whether children with additional needs achieved AAL (n= 27) or not (n =25). Children undertook standardised spoken language assessments on joining the AV programme and then at intervals of at least 6 months for the duration of their programme. Derived measures of rates of language development (RLD) were used to compare the groups at i) the outset (initial RLD), and ii) the conclusion of the AV programme (programme RLD).

Results

Overall, 79% of children within this cohort achieved age appropriate spoken language scores. Children with additional needs (40%) embarked on a non-statutory AV programme at a significantly older age (corrected for prematurity), with significantly lower initial RLD and, as a group, attained significantly lower programme RLD compared with children with deafness alone. One in two of the children with additional needs reached AAL by the end of their individualised programme. The children with additional needs also demonstrated a highly significant increase in their mean programme RLD compared with the mean initial RLD indicating an acceleration in acquiring spoken language competencies while on the AV programme.

Conclusions

For deaf children with additional needs who stay on an AV programme for more than two years, listening and spoken communication is significantly enhanced. Specific access to the AV approach in addition to generic, statutory early intervention could facilitate deaf children with additional needs to achieve or approach AAL. Ensuring families have access to effective early intervention increases the chances that i) a suitable communication approach is adopted at the earliest opportunity, and ii) a child with additional needs acquires listening and spoken language at a rate commensurate with their full potential. Applying the SNOMED CT framework as a means of categorizing children's additional needs will enable more effective comparisons across studies from different centres around the world.

https://ift.tt/2IjNd7l

Guideline “Implantable hearing aids”—short version

https://ift.tt/2zuyuUr

Comparative assessment of hand joint ultrasound findings in symptomatic patients with systemic lupus erythematosus and Sjögren's syndrome - a pilot study

Lei, L; Morgan, S; Ntatsaki, E; Ciurtin, C; (2018) Comparative assessment of hand joint ultrasound findings in symptomatic patients with systemic lupus erythematosus and Sjögren's syndrome - a pilot study. Ultrasound in Medicine & Biology (In press).

https://ift.tt/2Dy9UpL

Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions

Torii, R; Stettler, R; Räber, L; Zhang, YJ; Karanasos, A; Dijkstra, J; Patel, K; ... Bourantas, CV; + view all Torii, R; Stettler, R; Räber, L; Zhang, YJ; Karanasos, A; Dijkstra, J; Patel, K; Crake, T; Hamshere, S; Garcia-Garcia, HM; Tenekecioglu, E; Ozkor, M; Baumbach, A; Windecker, S; Serruys, PW; Regar, E; Mathur, A; Bourantas, CV; - view fewer (2018) Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions. International Journal of Cardiology 10.1016/j.ijcard.2018.06.065 . (In press).

https://ift.tt/2xE4Evn

Semantic Web Technologies for CrossCult

Bikakis, A; (2018) Semantic Web Technologies for CrossCult. In: Bikakis, A and Jean, S and Markhoff, B and Mosca, A, (eds.) Proceedings of the Semantic Web for Cultural Heritage (SW4CH 2018). RWTH Aachen University: Aachen, Germany. Green open access

https://ift.tt/2DwMeSq

Dayside Magnetospheric and Ionospheric Responses to a Foreshock Transient on 25 June 2008: 1. FLR Observed by Satellite and Ground-Based Magnetometers

Shen, XC; Shi, Q; Wang, B; Zhang, H; Hudson, MK; Nishimura, Y; Hartinger, MD; ... Degeling, AW; + view all Shen, XC; Shi, Q; Wang, B; Zhang, H; Hudson, MK; Nishimura, Y; Hartinger, MD; Tian, A; Zong, QG; Rae, IJ; Degeling, AW; - view fewer (2018) Dayside Magnetospheric and Ionospheric Responses to a Foreshock Transient on 25 June 2008: 1. FLR Observed by Satellite and Ground-Based Magnetometers. Journal of Geophysical Research: Space Physics 10.1029/2018JA025349 . (In press). Green open access

https://ift.tt/2xzPF5B

Integrated Building Life cycle Carbon and Cost Analysis Embedding Multiple Optimisation Levels

Eleftheriadis, S; Schwartz, Y; Raslan, RM; Duffour, P; Mumovic, D; (2018) Integrated Building Life cycle Carbon and Cost Analysis Embedding Multiple Optimisation Levels. In: Proceedings of the Fourth IBSPA - England Conference:Building Simulation and Optimization 2018 (BSO 2018). IBPSA-England: Emmanuel College, University of Cambridge, UK. (In press).

https://ift.tt/2Dt9FvY

Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing

Lawes, S; Demakakos, P; Steptoe, A; Lewis, G; Carvalho, LA; (2018) Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing. Psychological Medicine 10.1017/S003329171800209X . Green open access

https://ift.tt/2xD96uq

The 2015 edition of the GEISA spectroscopic database

Jacquinet-Husson, N; Armante, R; Scott, NA; Chedin, A; Crepeau, L; Boutammine, C; Bouhdaoui, A; ... Makie, A; + view all Jacquinet-Husson, N; Armante, R; Scott, NA; Chedin, A; Crepeau, L; Boutammine, C; Bouhdaoui, A; Crevoisier, C; Capelle, V; Boonne, C; Poulet-Crovisier, N; Barbe, A; Benner, DC; Boudon, V; Brown, LR; Buldyreva, J; Campargue, A; Coudert, LH; Devi, VM; Down, MJ; Drouin, BJ; Fayt, A; Fittschen, C; Flaud, J-M; Gamache, RR; Harrison, JJ; Hill, C; Hodnebrog, O; Hu, S-M; Jacquemart, D; Jolly, A; Jimenez, E; Lavrentieva, NN; Liu, A-W; Lodi, L; Lyulin, OM; Massie, ST; Mikhailenko, S; Mueller, HSP; Naumenko, OV; Nikitin, A; Nielsen, CJ; Orphal, J; Perevalov, VI; Perrin, A; Polovtseva, E; Predoi-Cross, A; Rotger, M; Ruth, AA; Yu, SS; Sung, K; Tashkun, SA; Tennyson, J; Tyuterev, VIG; Auwera, JV; Voronin, BA; Makie, A; - view fewer (2016) The 2015 edition of the GEISA spectroscopic database. Journal of Molecular Spectroscopy , 327 pp. 31-72. 10.1016/j.jms.2016.06.007 . Green open access

https://ift.tt/2DFHIRY

Impact of tectonic and volcanism on the Neogene evolution of isolated carbonate platforms (SW Indian Ocean)

Courgeon, S; Jorry, SJ; Jouet, G; Camoin, G; BouDagher-Fadel, MK; Bachèlery, P; Caline, B; ... Guérin, C; + view all Courgeon, S; Jorry, SJ; Jouet, G; Camoin, G; BouDagher-Fadel, MK; Bachèlery, P; Caline, B; Boichard, R; Révillon, S; Thomas, Y; Thereau, E; Guérin, C; - view fewer (2017) Impact of tectonic and volcanism on the Neogene evolution of isolated carbonate platforms (SW Indian Ocean). Sedimentary Geology , 355 pp. 114-131. 10.1016/j.sedgeo.2017.04.008 . Green open access

https://ift.tt/2xGQqd1

Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO (c)) Scores in Influenza-Positive Patients

Powers, JH; Bacci, ED; Lourdes Guerrero, M; Leidy, NK; Stringer, S; Kim, K; Memoli, MJ; ... Ruiz-Palacios, GM; + view all Powers, JH; Bacci, ED; Lourdes Guerrero, M; Leidy, NK; Stringer, S; Kim, K; Memoli, MJ; Han, A; Fairchok, MP; Chen, W-J; Arnold, JC; Danaher, PJ; Lalani, T; Ridore, M; Burgess, TH; Millar, EV; Hernandez, A; Rodriguez-Zulueta, P; Smolskis, MC; Ortega-Gallegos, H; Pett, S; Fischer, W; Gillor, D; Moreno Macias, L; DuVal, A; Rothman, R; Dugas, A; Ruiz-Palacios, GM; - view fewer (2018) Reliability, Validity, and Responsiveness of InFLUenza Patient-Reported Outcome (FLU-PRO (c)) Scores in Influenza-Positive Patients. Value in Health , 21 (2) pp. 210-218. 10.1016/j.jval.2017.04.014 . Green open access

https://ift.tt/2Du53pi

The human behaviour-change project: Developing a behaviour change intervention ontology

Norris, E; Finnerty, A; Marques, M; West, R; Thomas, J; Aonghusa, PM; Johnston, M; ... Michie, S; + view all Norris, E; Finnerty, A; Marques, M; West, R; Thomas, J; Aonghusa, PM; Johnston, M; Kelly, MP; Michie, S; - view fewer (2017) The human behaviour-change project: Developing a behaviour change intervention ontology. In: Horridge, M and Lord, P and Warrender, J D, (eds.) Proceedings of the 8th International Conference on Biomedical Ontology (ICBO 2017). CEUR: Newcastle-upon-Tyne, UK. Green open access

https://ift.tt/2xENVry

Obesity, perceived weight discrimination, and hair cortisol: a population-based study

Jackson, SE; Steptoe, A; (2018) Obesity, perceived weight discrimination, and hair cortisol: a population-based study. Psychoneuroendocrinology , 98 pp. 67-73. 10.1016/j.psyneuen.2018.08.018 .

https://ift.tt/2Du4NXm

The politics of precariousness. Josel of Rosheim and Jewish intercession in the Holy Roman empire in the 16th century

Guesnet, F; (2017) The politics of precariousness. Josel of Rosheim and Jewish intercession in the Holy Roman empire in the 16th century. Jewish Culture and History , 19 (1) pp. 8-22. 10.1080/1462169X.2017.1409994 .

https://ift.tt/2xCc428

The disappearance of a Late Jurassic remnant sea in the southern Qiangtang Block (Shamuluo Formation, Najiangco area): Implications for the tectonic uplift of central Tibet

Ma, A; Hu, X; Kapp, P; Han, Z; Lai, W; BouDagher-Fadel, M; (2018) The disappearance of a Late Jurassic remnant sea in the southern Qiangtang Block (Shamuluo Formation, Najiangco area): Implications for the tectonic uplift of central Tibet. Palaeogeography, Palaeoclimatology, Palaeoecology , 506 pp. 30-47. 10.1016/j.palaeo.2018.06.005 .

https://ift.tt/2Du4xYo

Development of targeted siRNA nanocomplexes to prevent fibrosis in experimental glaucoma filtration surgery

Fernando, O; Tagalakis, AD; Shiekh Hassan Awwad, S; Brocchini, S; Khaw, PT; Hart, S; Yu-Wai-Man, C; (2018) Development of targeted siRNA nanocomplexes to prevent fibrosis in experimental glaucoma filtration surgery. Molecular Therapy 10.1016/j.ymthe.2018.09.004 . (In press). Green open access

https://ift.tt/2xFouGC

Methodological dialogues across multimodality and sensory ethnography: digital touch communication

Jewitt, C; Leder Mackley, K; (2018) Methodological dialogues across multimodality and sensory ethnography: digital touch communication. Qualitative Research 10.1177/1468794118796992 . (In press). Green open access

https://ift.tt/2DvqOFx

Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ

Xekouki, P; Lodge, EJ; Matschke, J; Santambrogio, A; Apps, JR; Sharif, A; Jacques, TS; ... Andoniadou, C; + view all Xekouki, P; Lodge, EJ; Matschke, J; Santambrogio, A; Apps, JR; Sharif, A; Jacques, TS; Aylwin, S; Prevot, V; Li, R; Flitsch, J; Bornstein, SR; Theodoropoulou, M; Andoniadou, C; - view fewer (2018) Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ. Endocrine-Related Cancer 10.1530/ERC-18-0330 . (In press). Green open access

https://ift.tt/2xFYV8i

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling

Dobreva, MP; Escalona, VA; Lawson, KA; Sanchez, MN; Ponomarev, LC; Pereira, PNG; Stryjewska, A; ... Zwijsen, A; + view all Dobreva, MP; Escalona, VA; Lawson, KA; Sanchez, MN; Ponomarev, LC; Pereira, PNG; Stryjewska, A; Criem, N; Huylebroeck, D; Lopes, SMCDS; Aerts, S; Zwijsen, A; - view fewer (2018) Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling. Development , 145 (13) , Article dev157222. 10.1242/dev.157222 .

https://ift.tt/2DvqC9h

Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis

Fidler, K; Foster, C; Lim, EJ; Patel, A; Welch, S; Menson, E; Klein, N; ... Collaborative HIV Paediatric Study (CHIPS) Steering Committee, ; + view all Fidler, K; Foster, C; Lim, EJ; Patel, A; Welch, S; Menson, E; Klein, N; Judd, A; Collaborative HIV Paediatric Study (CHIPS) Steering Committee, ; - view fewer (2018) Reactivity of Routine HIV Antibody Tests in Children with Perinatally-Acquired HIV-1 in England: Cross Sectional Analysis. Pediatric Infectious Disease Journal 10.1097/INF.0000000000002143 . (In press).

https://ift.tt/2xDHxRk

Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study

Nyberg, ST; Batty, GD; Pentti, J; Virtanen, M; Alfredsson, L; Fransson, EI; Goldberg, M; ... Kivimäki, M; + view all Nyberg, ST; Batty, GD; Pentti, J; Virtanen, M; Alfredsson, L; Fransson, EI; Goldberg, M; Heikkilä, K; Jokela, M; Knutsson, A; Koskenvuo, M; Lallukka, T; Leineweber, C; Lindbohm, JV; Madsen, IEH; Magnusson Hanson, LL; Nordin, M; Oksanen, T; Pietiläinen, O; Rahkonen, O; Rugulies, R; Shipley, MJ; Stenholm, S; Suominen, S; Theorell, T; Vahtera, J; Westerholm, PJM; Westerlund, H; Zins, M; Hamer, M; Singh-Manoux, A; Bell, JA; Ferrie, JE; Kivimäki, M; - view fewer (2018) Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study. The Lancet Public Health 10.1016/S2468-2667(18)30139-7 . (In press). Green open access

https://ift.tt/2Du4oUQ

Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications

Dehghan-Manshadi, A; Chen, Y; Shi, Z; Bermingham, M; StJohn, D; Dargusch, M; Qian, M; (2018) Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications. Materials , 11 (9) 10.3390/ma11091573 . Green open access

https://ift.tt/2xENRbi

Giants in Allergy-Immunology: Richard Studley Farr, M.D.

Publication date: Available online 25 September 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Charles H. Kirkpatrick

https://ift.tt/2xQhMwt

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment

Abstract

Purpose of Review

Allergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies.

Recent Findings

Prenatal and early childhood events that generate microbiome modification are closely related with TLR activation. Early childhood exposure to a rich array of TLR agonists, particularly lipopolysaccharide, strongly predicts protection against allergic disease later in life even when other lifestyle factors are accounted for. Genetic deletion of TLR signaling components in mice results in reduced function of tolerogenic cell populations in the gut. In contrast, weak TLR signaling can promote allergic sensitization later in life.

Summary

This review summarizes the role of TLR signaling in microbiome-mediated protection against allergy.

https://ift.tt/2O6EScH

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects

Abstract

Purpose of Review

Telemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program.

Recent Findings

With the advent of new technologies including high-speed Internet, video conferencing solutions, and digital examination equipment, facilitated virtual visits as replacements for in-person visits are now possible. The technical requirements for a successful telemedicine program include secure, high-speed Internet connection, a clinical telemedicine cart to serve as the hub for the interaction, patient access software, and access to IT professionals to set up the program and to be available when the system malfunctions.

Summary

A carefully designed telemedicine program is more likely to be successful if the technical aspects are included in the planning process.

https://ift.tt/2xQnQoQ

Congenital Granular Cell Tumor: Case Report and Review

Congenital granular cell tumors are infrequently occurring masses occurring on a neonate's gingiva/alveolus. These lesions are benign with no noted malignant transformation, and treatment of excision is based on its effect on the neonate's respiratory ability and/or nutritional intake. The purpose of this review is to discuss a case of a congenital granular cell tumor and its treatment and review of the literature including demographics, histopathology, and operative treatment.

https://ift.tt/2xUaZ5g

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment

Abstract

Purpose of Review

Allergy and asthma are growing problems in the developed world. The accelerated increase of these diseases may be related to microbiome modification that leads to aberrant activation of Toll-like receptors (TLRs). Current research supports the concept that changes in microbial communities in early life impact TLR activation, resulting in an altered risk for the development of asthma and allergies.

Recent Findings

Prenatal and early childhood events that generate microbiome modification are closely related with TLR activation. Early childhood exposure to a rich array of TLR agonists, particularly lipopolysaccharide, strongly predicts protection against allergic disease later in life even when other lifestyle factors are accounted for. Genetic deletion of TLR signaling components in mice results in reduced function of tolerogenic cell populations in the gut. In contrast, weak TLR signaling can promote allergic sensitization later in life.

Summary

This review summarizes the role of TLR signaling in microbiome-mediated protection against allergy.

https://ift.tt/2O6EScH

Telemedicine Technology: a Review of Services, Equipment, and Other Aspects

Abstract

Purpose of Review

Telemedicine uses technology to connect patients with providers at a distance. While the clinical aspects of this have been reviewed extensively, the technical aspects are not as well understood by allergists when they consider adding telemedicine to their practice. This review focuses on the technical aspects of setting up a telemedicine program.

Recent Findings

With the advent of new technologies including high-speed Internet, video conferencing solutions, and digital examination equipment, facilitated virtual visits as replacements for in-person visits are now possible. The technical requirements for a successful telemedicine program include secure, high-speed Internet connection, a clinical telemedicine cart to serve as the hub for the interaction, patient access software, and access to IT professionals to set up the program and to be available when the system malfunctions.

Summary

A carefully designed telemedicine program is more likely to be successful if the technical aspects are included in the planning process.

https://ift.tt/2xQnQoQ

In vitro analysis of growth patterns of invasive fungal species on commonly used endonasal hemostatic agents

Publication date: Available online 25 September 2018

Source: American Journal of Otolaryngology

Author(s): Christopher Ito, Daniel Sharbel, Allison McMullen, Stilianos Kountakis

Abstract

Objective

Previous studies have not examined the potential role of endonasal hemostatic agents in facilitating growth of fungal species. We aim to determine the possibility of these to serve as a nutrient source for fungal growth.

Methods

Cultures of Aspergillus, Fusarium, and Mucor were harvested and placed in solution in sterile saline at standardized high and low concentrations. Thrombin gelatin matrix, carboxyl methylcelluose, and potato starch derivative agents were prepared following manufacturer instructions and applied to two separate Petri dishes per agent. Each substrate was then inoculated with either high or low concentrations of fungal species. A negative and positive control plates with each organism were included. Dishes were sealed, incubated, and examined daily for fourteen days for microscopic and macroscopic growth.

Results

Thrombin gelatin matrix was relatively resilient to growth, although Fusarium growth was noted on all packing material by day three. Carboxyl methylcellulose also supported growth of high-concentration Mucor appreciated on day five. The potato starch derivative supported fulminant growth of all fungal species.

Conclusions

Endonasal hemostatic agents may be nutrient sources that facilitate growth of fungal species. This may be a consideration in a surgeon's decision to use a hemostatic agent. Prompt initial post-operative debridement may be warranted in select patients. Our findings serve as a model for further testing of fungal growth on other hemostatic materials. Future studies are needed to confirm the clinical significance of these findings in vivo.

https://ift.tt/2IgmmsI

Taking Stock of Engineering Epistemology: Multidisciplinary Perspectives

Abstract

How engineers know, and act on that knowledge, has a profound impact on society. Consequently, the analysis of engineering knowledge is one of the central challenges for the philosophy of engineering. In this article, we present a thematic multidisciplinary conceptual survey of engineering epistemology and identify key areas of research that are still to be comprehensively investigated. Themes are organized based on a survey of engineering epistemology including research from history, sociology, philosophy, design theory, and engineering itself. Five major interrelated themes are identified: the relationship between scientific and engineering knowledge, engineering knowledge as a distinct field of study, the social epistemology of engineering, the relationship between engineering knowledge and its products, and the cognitive aspects of engineering knowledge. We discuss areas of potential future research that are underdeveloped or "undone."

https://ift.tt/2OQTeLn

CD19 + tumor-infiltrating B-cells prime CD4 + T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer

Abstract

Purpose

CD19⁺ tumor-infiltrating B-cells (CD19⁺ TIB) play a crucial role in tumorigenesis, but their clinical relevance in muscle-invasive bladder cancer (MIBC) remains unknown. This study aimed to investigate the prognostic value of CD19⁺ TIB for post-surgery survival and adjuvant chemotherapy response in MIBC.

Experimental design

We assessed TIB by immunohistochemical staining of CD19 in 246 MIBC patients from Zhongshan Hospital and Shanghai Cancer Center. We evaluated the survival benefit of platinum-based chemotherapy according to CD19⁺ TIB. The mechanism underlying CD19⁺ TIB antitumor immunity was explored through the Cancer Genome Atlas (TCGA) dataset analysis and an in vitro Ag presentation assay.

Results

CD19⁺ TIB extensively infiltrated into the tumor stroma of MIBC. Adjuvant chemotherapy (ACT) led to a significantly increased benefit in the high CD19⁺ TIB MIBC patients (P = 0.003). In multivariate analysis, high CD19⁺ TIB MIBC patients had significantly longer OS with ACT in the discovery set (HR = 0.487, P = 0.038). TCGA gene expression analyses showed enrichment of adaptive immunity, T-cell-mediated immunity, and antigen-presentation signaling pathways in high CD19⁺ TIB MIBC patients. Moreover, CD19⁺ TIB co-localized with activated CD4⁺ TIT and expressed surface markers characteristic of antigen-presenting cells. Finally, an antigen-presentation assay demonstrated the antigen-presentation function of CD19⁺ TIB.

Conclusion

CD19⁺ TIB was identified as an independent prognostic factor, which could predict for post-surgery survival and platinum-based ACT benefits in MIBC. CD19⁺ TIB serve as antigen-presenting cells (APCs) to activate CD4⁺ TIT in the tumor environment of MIBC.

https://ift.tt/2IkdxOU

Development of Novel Protocol to Al3+ Stress Tolerance at Germination Stage in Indica Rice through Statistical Approaches

Rice production is decreasing by abiotic stresses like heavy metals. In such circumstances, producing food for growing human population is a challenge for plant breeders. Excess of Al3+ in soil has become threat for high yield of rice. Improvement of crop is one of potential solution for high production. The aim of this study was to develop the new method for optimization of Al3+ toxicity tolerance in indica rice at germination stag using two-way ANOVA and Duncan's multiple-range test (DMRT). Seeds of two indica rice cultivars (Pokkali and Pak Basmati) were exposed in different concentrations (control, 5 mM, 15 mM, and 20 mM) of Al3+ toxicity at pH 4 ±0.2 for two weeks. Germination traits such as final germination percentage (FG%), germination energy (GE), germination speed (GS), germination index (GI), mean time of germination (MGT), germination value (GV), germination velocity (GVe), peak value of germination (GPV), and germination capacity (GC) and growth traits such as root length (RL), shoot length (SL), total dry biomass (TDB), and germination vigour index (GVI) were measured. To obtain the maximum number of significance (≤ 0.01%) parameters in each concentration of Al3+ toxicity with control, two-way ANOVA was established and comparison of mean was done using DMRT. The results showed that 5 mM, 10 mM, and 15 mM have less significant effects on the above-mentioned parameters. However, 20 mM concentration of Al3+ produced significant effects (≤ 0.01%). Therefore, 20 mM of Al3+ is considered optimized limit for indica cultivars (Pokkali and Pak Basmati).

https://ift.tt/2NHBMfM

Oncological and functional outcomes of trans-oral robotic surgery for pyriform sinus carcinoma: A French GETTEC group study

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Paul Mazerolle, Pierre Philouze, Renaud Garrel, Karine Aubry, Sylvain Morinière, Sophie El Bedoui, Jean Ton Van, Christophe Ferron, Olivier Malard, Franck Jegoux, Emilie Berard, Sébastien Vergez

Abstract

Background

Pyriform sinus carcinomas (SCC) present specific functional and oncological issues. The recent advent of trans-oral robotic surgery (TORS), as a conservative procedure, has opened up new perspectives.

Objectives

To present the oncological and functional outcomes of TORS for pyriform sinus SCC.

Materials and methods

We included, retrospectively, all TORS procedures for pyriform sinus SCC performed between 2009 and 2017 in eight French tertiary referral centers. We excluded lesions involving the pyriform sinus that had developed from the oropharynx, larynx, or other anatomic sub-sites of the hypopharynx.

Results

We included 57 TORS procedures. Median hospital stay was 10 days. A preventive tracheotomy was performed in seven cases (12%), and all were successfully decannulated. Oral re-feeding was possible for 93%, after a median of 5 days. The main surgical complications were hemorrhages (three cases), all successfully handled, although 2 patients with heavy comorbidities died from blood loss in the days after. Adjuvant therapy was proposed in 31 cases (54%), including two cases of salvage surgery (total pharyngolaryngectomy). After a median follow-up of 23 months, overall and disease-free survival were, respectively, 84% and 74% at 24 months, and 66% and 50% at 48 months. At the end of follow-up, organ preservation rate was 96%. None of the surviving patients needed a tracheotomy and oral diet was possible for 96%.

Conclusion

The functional and oncological outcomes of TORS for pyriform sinus cancer are encouraging, and this procedure can be considered safe for selected early or moderately advanced cases as a conservative treatment.

https://ift.tt/2MZQkC1

Triggering TLR3 pathway promotes tumor growth and cisplatin resistance in head and neck cancer cells

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Hui-Ching Chuang, Ming-Huei Chou, Chih-Yen Chien, Jiin-Haur Chuang, Yu-Li Liu

Abstract

Over the last decades, significant advances in targeted therapies have helped provide more effective treatment for head and neck cancer patients. However, chemo-resistance to cisplatin significantly contributes to treatment failure in the clinical management of patients. In response to chemotherapeutic agents, certain molecules inside the cell are released or secreted from damaged or dead/dying cells, named damage-associated molecular patterns (DAMPs), thereby initiating an immune response through interaction with pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs).

In present study, we investigated the link between cisplatin-induced DAMPs and TLR3 signaling. We found that cisplatin could be a potential activator of TLR3 and cisplatin treatment results in activation of PRRs' signaling and down-stream associated cytokine/chemokine, IFNβ, and CCL5 in TLR3^High OC2 cells, but not in TLR3^Low FaDu cells. Furthermore, knockdown of the TLR3 gene attenuates the expression of IFNβ and CCL5 mRNA and enhances the cytotoxicity of cisplatin in TLR3^High OC2 cells.

To determine whether TLR3 status affects the stress response of OC2 cells to cisplatin, we generated TLR3 knockdown OC2 cells (psi-TLR3 cells) with a psiRNA-hTLR3 plasmid containing shRNA to TLR3 and control OC2 cells (psi-NT cells) expressing non-silencing shRNA. OC2 cells were more sensitive to cisplatin treatment after TLR3 knockdown. In our animal model, OC2 psi-NT cells were more tumorigenic than were OC2 psi-TLR3 cells. Together, our in vitro and in vivo data imply TLR3 may contribute to tumor development and protect cisplatin-induced DNA damage response leading to cisplatin resistance in head and neck cancer cells.

https://ift.tt/2zvbSDl

Performance of different imaging techniques in the diagnosis of head and neck cancer mandibular invasion: A systematic review and meta-analysis

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Xianghe Qiao, Wei Liu, Yubin Cao, Cheng Miao, Wenbin Yang, Naichuan Su, Li Ye, Longjiang Li, Chunjie Li

Abstract

Background

To assess diagnostic efficacy of imaging techniques for mandibular invasion by head and neck cancer.

Methods

Thirteen databases were searched. Study inclusion, data-extraction and quality assessment were performed independently. STATA 14.0 were mainly used for meta-analysis.

Results

Forty-nine studies were included. For mandibular invasion (cortex and marrow), CBCT, SPECT, CT, MRI, orthopantomography, PET-CT and bone-scintigraphy showed pooled sensitivities of 90%, 97%, 73%, 88%, 75%, 90%, 92%, specificities of 85%, 69% 91%, 90%, 83%, 89%, 79%, AUC of 0.9461, 0.9434, 0.8995, 0.9296, 0.8761, 0.9290, 0.9207, respectively. The combined SROC curves indicated CBCT and SPECT were superior to other techniques. For mandibular medullary invasion (marrow), CT and MRI showed pooled sensitivities of 85% and 93%, specificities of 86% and 84%.

Conclusions

CBCT was top-priority choice for bone invasion diagnosis. SPECT was recommended for exclusion, CT and MRI were suitable for conformation. Further investigations are needed for mandibular medullary involvement.

https://ift.tt/2N2ITdm

The interplay of IMRT and transoral surgery in HPV-mediated oropharyngeal cancer: Getting the balance right

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Shao Hui Huang, Ezra Hahn, Raymond K. Tsang, Zhi-Jian Chen, Brian O'Sullivan

Abstract

Transoral surgery (TOS) and IMRT represent two primary local ablative treatment modalities for oropharyngeal cancer (OPC). The choice of one over the other represents an interplay between the chance of cure vs risk of late sequelae. HPV-mediated (HPV+) OPC patients generally have excellent outcomes, especially in TNM-8 stage I disease. Controversies exist over which treatment has a more favorable toxicity profile and equal efficacy in the management of this population. Non-randomized retrospective data show comparable oncological and functional outcomes between TOS-based vs IMRT-based treatment for this disease. Several de-intensification concepts have been explored in this subset in both primary surgery-based vs primary radiotherapy-based trials. However, no robust mature trial data are available to convincingly guide treatment selection. TOS is often presented as one of the de-intensification options although the majority of series also describe the use of adjuvant treatments which inevitably result in non-negligible toxicities. Patient selection and surgeons' training are paramount. Understanding tumor biology and the prognostic value of traditional 'adverse' features will further guide trial design for refinement of risk tailored approach. In conclusion, comparative data suggests TOS and IMRT are both effective treatment for TNM-8 stage I HPV+ OPC with similar oncological and functional outcomes. TOS as a single modality has potential advantages in mitigating radiation included toxicities. TOS should be avoided in the presence of clinically overt extranodal extension or when negative margins are unlikely to be achieved. TOS is also less ideal for cases with radiological features predicting a high risk of distant metastasis.

https://ift.tt/2NJbdGU

Quantitative profiling of cytokines and chemokines in DOCK8 deficient and Atopic dermatitis patients

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2DvFeW3

Patient‐reported outcomes: A 5‐year long study reveals previously unreported therapeutic, demographic, socio‐economic, and other correlations in vitiligo

Dermatologic Therapy, EarlyView.


https://ift.tt/2Ih0WM8

Efficacy of oral tranexemic acid in refractory melasma: A clinico–immuno‐histopathological study

Dermatologic Therapy, EarlyView.


https://ift.tt/2QYKS5C

Occlusion therapy in inflammatory cutaneous diseases

Dermatologic Therapy, EarlyView.


https://ift.tt/2Il6BRy

Efficacy of topical calcineurin inhibitors in pyoderma gangrenosum

Dermatologic Therapy, EarlyView.


https://ift.tt/2QYKynq

Sequential methyl‐aminolevulinate daylight photodynamic therapy and diclofenac plus hyaluronic acid gel treatment for multiple actinic keratosis evaluation

Dermatologic Therapy, EarlyView.


https://ift.tt/2Iitd5d

Remittive effect of Dupilumab in atopic dermatitis

Dermatologic Therapy, EarlyView.


https://ift.tt/2QXIPPc

Prevention and management of iatrogenic blindness associated with aesthetical filler injections

Dermatologic Therapy, EarlyView.


https://ift.tt/2IgFVkR

Efficacy, safety, and cost‐effectiveness of all‐trans retinoic acid/Clobetasol Propionate Compound Ointment in the treatment of mild to moderate psoriasis vulgaris: A randomized, single‐blind, multicenter clinical trial

Dermatologic Therapy, EarlyView.


https://ift.tt/2QZsolq

Use of botulinum toxin in the treatment of aquagenic keratoderma: One case report

Dermatologic Therapy, EarlyView.


https://ift.tt/2Ihyvhj

Controversies in the treatment of androgenetic alopecia: The history of finasteride

Dermatologic Therapy, EarlyView.


https://ift.tt/2QZmqRF

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma with Unique HPV type 52 Association: A Case Report with Review of Literature

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently described distinctive clinicopathologic entity defined by association to high risk HPV, localization to sinonasal tract and close histologic resemblance to salivary gland tumors. Lack of awareness of its pathologic features and biology among pathologists and oncologists make this entity susceptible to misdiagnosis and erroneous management. Herein, we illustrate a case of HMSC of the nasal cavity associated with heretofore unreported subtype HPV-52 and discuss the challenges associated with diagnosis and management of this rare tumor. A 48-year-old woman with intermittent epistaxis for 6 months presented with a nasal mass and underwent middle turbinectomy. Histology showed a tumor with features typical of adenoid cystic carcinoma (ACC) in the form of basaloid cells and cribriform architecture. However, careful inspection revealed findings uncommon in ACC; such as surface pagetoid tumor spread, areas of solid sheets of myoepithelial cells accompanied by increased mitotic figures which prompted immunohistochemistry. Multidirectional differentiation into ductal (CK7, AE1/AE3) and myoepithelial (p63, p40, S100, calponin) lineage together with strong and diffuse immunopositivity for p16 distinguished this tumor from ACC. HPV genotyping was positive for high risk HPV subtype HPV52, which confirmed the diagnosis of HMSC. HPV-related multiphenotypic sinonasal carcinoma is an under-recognized unique clinicopathologic entity that needs awareness to avoid mistaking it for commoner salivary gland tumors. Making accurate diagnosis of this newly-described tumor is imperative in order to understand its biology and to develop optimal therapeutic strategies.

https://ift.tt/2NDfJqm

Solitary facial cutaneous chronic inflammatory lesions induced by anti‐tumour necrosis factor‐α antagonist

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2zu5JqX

Topical sodium thiosulfate for calcinosis cutis associated with autoimmune connective tissue diseases: the Mayo Clinic experience, 2012–2017

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2OObULK

Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2zu6GiU

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma with Unique HPV type 52 Association: A Case Report with Review of Literature

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently described distinctive clinicopathologic entity defined by association to high risk HPV, localization to sinonasal tract and close histologic resemblance to salivary gland tumors. Lack of awareness of its pathologic features and biology among pathologists and oncologists make this entity susceptible to misdiagnosis and erroneous management. Herein, we illustrate a case of HMSC of the nasal cavity associated with heretofore unreported subtype HPV-52 and discuss the challenges associated with diagnosis and management of this rare tumor. A 48-year-old woman with intermittent epistaxis for 6 months presented with a nasal mass and underwent middle turbinectomy. Histology showed a tumor with features typical of adenoid cystic carcinoma (ACC) in the form of basaloid cells and cribriform architecture. However, careful inspection revealed findings uncommon in ACC; such as surface pagetoid tumor spread, areas of solid sheets of myoepithelial cells accompanied by increased mitotic figures which prompted immunohistochemistry. Multidirectional differentiation into ductal (CK7, AE1/AE3) and myoepithelial (p63, p40, S100, calponin) lineage together with strong and diffuse immunopositivity for p16 distinguished this tumor from ACC. HPV genotyping was positive for high risk HPV subtype HPV52, which confirmed the diagnosis of HMSC. HPV-related multiphenotypic sinonasal carcinoma is an under-recognized unique clinicopathologic entity that needs awareness to avoid mistaking it for commoner salivary gland tumors. Making accurate diagnosis of this newly-described tumor is imperative in order to understand its biology and to develop optimal therapeutic strategies.

https://ift.tt/2NDfJqm

Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial

British Journal of Dermatology, EarlyView.


https://ift.tt/2xDhhqz

Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xCNo9U

Acute generalized exanthematous pustulosis induced by terbinafine in a child confirmed by patch testing

International Journal of Dermatology, EarlyView.


https://ift.tt/2Q3Ynjc

Antineutrophil cytoplasmic antibodies negative levamisole‐induced leukocytoclastic vasculitis: a presumed case and literature review

International Journal of Dermatology, EarlyView.


https://ift.tt/2xFw7wN

Networks for Future Services in a Smart City: Lessons Learned from the Connected OFCity Challenge 2017

Lavery, D; Ruffini, M; Valcarenghi, L; Yoshimoto, N; Pfeiffer, T; Hood, D; Zhang, J; ... Wey, JS; + view all Lavery, D; Ruffini, M; Valcarenghi, L; Yoshimoto, N; Pfeiffer, T; Hood, D; Zhang, J; King, D; Roberts, H; Yadav, R; Sambo, N; Tacca, M; Fichera, S; Tecchia, F; Carrozzino, M; Wong, E; Cheng, N; Yoshida, Y; Khotimsky, D; Wey, JS; - view fewer (2018) Networks for Future Services in a Smart City: Lessons Learned from the Connected OFCity Challenge 2017. IEEE Communications Magazine , 56 (8) pp. 138-144. 10.1109/MCOM.2018.1701084 . Green open access

https://ift.tt/2xQbXiS

Reply to: Association Between Alendronate and All‐Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation

Sing, CW; Wong, AYS; Kiel, DP; Cheung, EYN; Lam, JKY; Cheung, TT; Chan, EW; ... Cheung, CL; + view all Sing, CW; Wong, AYS; Kiel, DP; Cheung, EYN; Lam, JKY; Cheung, TT; Chan, EW; Kung, AWC; Wong, ICK; Cheung, CL; - view fewer (2018) Reply to: Association Between Alendronate and All‐Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation. [Letter]. Journal of Bone and Mineral Research 10.1002/jbmr.3568 . (In press).

https://ift.tt/2QZqyRx

Modular designs and integrating practices: Managing collaboration through coordination and cooperation

Tee, R; Davies, A; Whyte, J; (2018) Modular designs and integrating practices: Managing collaboration through coordination and cooperation. Research Policy 10.1016/j.respol.2018.07.017 . (In press).

https://ift.tt/2xRW7UL

A review on applications of shape-stabilized phase change materials embedded in building enclosure in recent ten years

Zhu, N; Li, S; Hu, P; Wei, S; Deng, R; Lei, F; (2018) A review on applications of shape-stabilized phase change materials embedded in building enclosure in recent ten years. Sustainable Cities and Society , 43 pp. 251-264. 10.1016/j.scs.2018.08.028 .

https://ift.tt/2QXuL8m

Editorial: Life course research around the world

Joshi, H; (2017) Editorial: Life course research around the world. Longitudinal and Life Course Studies , 8 (4) pp. 317-318. 10.14301/llcs.v8i4.481 . Green open access

https://ift.tt/2xTRaem

The REMOVAL trial: metformin reduces progression of mean carotid intima-media thickness (cIMT) in never smokers with type 1 diabetes

Petrie, JR; Chaturvedi, N; Ford, I; Brouwers, MCG; Greenlaw, N; Hramiak, I; Hughes, AD; ... Colhoun, HM; + view all Petrie, JR; Chaturvedi, N; Ford, I; Brouwers, MCG; Greenlaw, N; Hramiak, I; Hughes, AD; Jenkins, AJ; Klein, BEK; Klein, R; Rossing, P; Stehouwer, CDA; Sattar, N; Colhoun, HM; - view fewer (2018) The REMOVAL trial: metformin reduces progression of mean carotid intima-media thickness (cIMT) in never smokers with type 1 diabetes. Presented at: The 54th Annual Meeting of the European Association for the Study of Diabetes, Berlin, Germany. (In press).

https://ift.tt/2QZqa5x

Practice-based ontological design for multiplying realities

Nold, C; (2018) Practice-based ontological design for multiplying realities. Strategic Design Research Journal , 11 (2) pp. 58-64. 10.4013/sdrj.2018.112.02 . Green open access

https://ift.tt/2xLS5x2

Impact of transceiver subsystems on high-capacity optical transmission

Galdino, L; Semrau, D; Sillekens, E; Lavery, D; Killey, RI; Bayvel, P; (2018) Impact of transceiver subsystems on high-capacity optical transmission. In: Proceedings of the Signal Processing in Photonic Communications 2018. OSA Publishing: Zurich, Switzerland.

https://ift.tt/2QZgDLO

My Life is but a weaving: embroidering geographies of faith and place

Dwyer, C; Beinart, K; Ahmed, N; (2018) My Life is but a weaving: embroidering geographies of faith and place. Cultural Geographies 10.1177/1474474018792703 . (In press). Green open access

https://ift.tt/2xLRZ8E

A new prognostic model for myeloma patients relapsing from upfront autologous transplantation based on ISS and PFS1

Chavda, SJ; Maciocia, PM; Mesiri, P; Counsell, N; Kothari, J; Bird, A; Mariner, C; ... Yong, K; + view all Chavda, SJ; Maciocia, PM; Mesiri, P; Counsell, N; Kothari, J; Bird, A; Mariner, C; Chew, A; Clesham, K; Moore, S; Percy, L; Rismani, A; D'Sa, S; Rabin, N; Popat, R; Yong, K; - view fewer (2018) A new prognostic model for myeloma patients relapsing from upfront autologous transplantation based on ISS and PFS1. British Journal of Haematology 10.1111/bjh.15487 . (In press).

https://ift.tt/2QXuv9o

Editorial: Common threads in a rich tapestry

Joshi, H; (2017) Editorial: Common threads in a rich tapestry. Longitudinal and Life Course Studies , 8 (3) pp. 225-226. 10.14301/llcs.v8i3.472 . Green open access

https://ift.tt/2xQ4mAI

Loss of Local Tumor Control After Index Surgery for Spinal Metastases: A Prospective Cohort Study

Depreitere, B; Ricciardi, F; Arts, M; Balabaud, L; Buchowski, JM; Bunger, C; Chung, CK; ... Choi, D; + view all Depreitere, B; Ricciardi, F; Arts, M; Balabaud, L; Buchowski, JM; Bunger, C; Chung, CK; Coppes, MH; Fehlings, MG; Kawahara, N; Lee, C-S; Leung, Y; Antonio Martin-Benlloch, J; Massicotte, EM; Mazel, C; Meyer, B; Oner, FC; Peul, W; Quraishi, N; Tokuhashi, Y; Tomita, K; Ulbricht, C; Verlaan, JJ; Wang, M; Crockard, HA; Choi, D; - view fewer (2018) Loss of Local Tumor Control After Index Surgery for Spinal Metastases: A Prospective Cohort Study. World Neurosurgery , 117 e8-e16. 10.1016/j.wneu.2018.04.170 .

https://ift.tt/2QYy6Ec

Analysis of Nyquist Pulse Shapes for Carrier-less Amplitude and Phase Modulation in Visible Light Communications

Haigh, PA; Chvojka, P; Zvanovec, S; Ghassemlooy, Z; Darwazeh, I; (2018) Analysis of Nyquist Pulse Shapes for Carrier-less Amplitude and Phase Modulation in Visible Light Communications. Journal of Lightwave Technology 10.1109/JLT.2018.2869022 . (In press). Green open access

https://ift.tt/2xPydt3

RNA-Seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature

Chapman, MA; Sive, J; Ambrose, J; Roddie, C; Counsell, N; Lach, A; Abbasian, M; ... Yong, K; + view all Chapman, MA; Sive, J; Ambrose, J; Roddie, C; Counsell, N; Lach, A; Abbasian, M; Popat, R; Cavenagh, JD; Oakervee, H; Streetly, MJ; Schey, S; Koh, M; Willis, F; Virchis, AE; Crowe, J; Quinn, MF; Cook, G; Crawley, CR; Pratt, G; Cook, M; Braganza, N; Adedayo, T; Smith, P; Clifton-Hadley, L; Owen, RG; Sonneveld, P; Keats, JJ; Herrero, J; Yong, K; - view fewer (2018) RNA-Seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature. Blood 10.1182/blood-2018-05-849893 . (In press).

https://ift.tt/2QWsTg9

Expert's Comment concerning Grand Rounds case entitled "Idiopathic spinal cord herniation: consideration of its pathogenesis based on the histopathology of the dura mater'' by S. Shimizu et al. (Eur Spine J; 2017. DOI 10.1007/s00586-017-5147-y).

Choi, D; (2018) Expert's Comment concerning Grand Rounds case entitled "Idiopathic spinal cord herniation: consideration of its pathogenesis based on the histopathology of the dura mater'' by S. Shimizu et al. (Eur Spine J; 2017. DOI 10.1007/s00586-017-5147-y). [Letter]. European Spine Journal 10.1007/s00586-018-5609-x . (In press). Green open access

https://ift.tt/2xLRCeg

Characteristics of high-intensity groundwater abstractions from weathered crystalline bedrock aquifers in East Africa

Maurice, L; Taylor, RG; Tindimugaya, C; MacDonald, AM; Johnson, P; Kaponda, A; Owor, M; ... Gooddy, D; + view all Maurice, L; Taylor, RG; Tindimugaya, C; MacDonald, AM; Johnson, P; Kaponda, A; Owor, M; Sanga, H; Bonsor, HC; Darling, WG; Gooddy, D; - view fewer (2018) Characteristics of high-intensity groundwater abstractions from weathered crystalline bedrock aquifers in East Africa. Hydrogeology Journal 10.1007/s10040-018-1836-9 . (In press). Green open access

https://ift.tt/2QZfqUY

Local species assemblages are influenced more by past than current dissimilarities in photosynthetic activity

Jung, M; Rowhani, P; Newbold, T; Bentley, L; Purvis, A; Scharlemann, J; (2018) Local species assemblages are influenced more by past than current dissimilarities in photosynthetic activity. Ecography 10.1111/ecog.04031 . (In press).

https://ift.tt/2xLRueM

Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2)

Choi, D; (2018) Expert's comment concerning Grand Rounds case entitled "Malignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor" by S. Ghailane et al. (Eur Spine J; 2017: DOI 10.1007/s00586-017-5277-2). [Letter]. European Spine Journal 10.1007/s00586-018-5607-z . (In press). Green open access

https://ift.tt/2QXurGG

Unexpected diversity within the extinct elephant birds (Aves: Aepyornithidae) and a new identity for the world’s largest bird

Hansford, JP; Turvey, ST; (2018) Unexpected diversity within the extinct elephant birds (Aves: Aepyornithidae) and a new identity for the world's largest bird. Royal Society Open Science (In press).

https://ift.tt/2xQ9d4S

Modality selective roles of pro-nociceptive spinal 5-HT₂_{A} and 5-HT₃ receptors in normal and neuropathic states

Patel, R; Dickenson, AH; (2018) Modality selective roles of pro-nociceptive spinal 5-HT₂_{A} and 5-HT₃ receptors in normal and neuropathic states. Neuropharmacology , 143 pp. 29-37. 10.1016/j.neuropharm.2018.09.028 . Green open access

https://ift.tt/2QYy3s0

Telogen hair loss and androgenetic‐like alopecia in GAPO syndrome

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2NJLcYb

Use of a qualitative case study to learn lessons from severe preeclampsia causing a maternal near-miss: a case report

Maternal mortality is a critical indicator in assessing the quality of services provided by a health care system. Approximately 99% of all maternal deaths occur in developing countries; where a majority of the...

https://ift.tt/2xCK2DQ