Post-bariatric abdominoplasty resulting in wound infection and dehiscence-Conservative treatment with medical grade honey: A case report and review of literature.

Post-bariatric abdominoplasty resulting in wound infection and dehiscence-Conservative treatment with medical grade honey: A case report and review of literature.

Int J Surg Case Rep. 2016 Jan 7;20:1-3

Authors: Dina Jarjis R, Thomas Crewe B, Henrik Matzen S

Abstract
INTRODUCTION: Wound complications in post-bariatric patients undergoing body-contouring surgery after massive weight loss are not uncommon and often, surgical debridement or conservative management is necessary. Honey is one of the most ancient remedies for wound care and it is also considered to possess debriding effects. Current research has demonstrated promising results showing that honey can improve wound granulation and epithelialization, reduce exudate and shorten healing times.
METHODS: This case report has been reported in line with the CARE criteria.
PRESENTATION OF CASE: A 40 year-old female suffered wound infection and dehiscence after undergoing post-bariatric abdominoplasty. The patient was not interested in surgical revision and split skin grafting. Therefore, conservative wound treatment with topical Manuka honey was instituted resulting in significant clinical improvement and effective healing concurrently with good patient satisfaction.
DISCUSSION: Surgical wound complications in post-bariatric patients undergoing abdominoplasty are common and often require surgical revision or conservative wound treatment. No previous publication has addressed outpatient treatment of post-bariatric abdominoplasty wound complications with medical grade honey.
CONCLUSION: Although more research is needed for definitive conclusions of honey's efficacy, it is safe and as presented in our case, it may under certain circumstances reduce the need of surgical wound debridement and serve as a remedy for conservative treatment.

PMID: 26773204 [PubMed - as supplied by publisher]

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Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: results of a randomized controlled trial.

Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: results of a randomized controlled trial.

Hear Res. 2016 Jan 7;

Authors: Malinvaud D, Londero A, Niarra R, Peignard P, Warusfel O, Viaud-Delmon I, Chatellier G, Bonfils P

Abstract
BACKGROUND: Subjective tinnitus (ST) is a frequent audiologic condition that still requires effective treatment. This study aimed at evaluating two therapeutic approaches: Virtual Reality (VR) immersion in auditory and visual 3D environments and Cognitive Behaviour Therapy (CBT).
METHODS: this open, randomized and therapeutic equivalence trial used bilateral testing of VR versus CBT. Adult patients displaying unilateral or predominantly unilateral ST, and fulfilling inclusion criteria were included after giving their written informed consent. We measured the different therapeutic effect by comparing the mean scores of validated questionnaires and visual analog scales, pre and post protocol. Equivalence was established if both strategies did not differ for more than a predetermined limit. We used univariate and multivariate analysis adjusted on baseline values to assess treatment efficacy. In addition of this trial, purely exploratory comparison to a waiting list group (WL) was provided.
RESULTS: Between August, 2009 and November, 2011, 148 of 162 screened patients were enrolled (VR n = 61, CBT n = 58, WL n = 29). These groups did not differ at baseline for demographic data. Three month after the end of the treatment, we didn't find any difference between VR and CBT groups either for tinnitus severity (p=0.99) or tinnitus handicap (p=0.36).
CONCLUSION: VR appears to be at least as effective as CBT in unilateral ST patients.

PMID: 26773752 [PubMed - as supplied by publisher]

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[Respiratory and intensive care aspects of muscular dystrophies].

[Respiratory and intensive care aspects of muscular dystrophies].

Arch Pediatr. 2015 Dec;22(12S1):12S51-12S57

Authors: Ambrosi X, Lamothe L, Heming N, Orlikowski D

Abstract
Among the various myopathies, Duchenne muscular dystrophy represents the myopathy with the most stereotypical respiratory evolution. This progressive respiratory failure is going to develop in a parallel way of motor deficit, conducting patients to mechanical ventilation at the end of their second decade. In the absence of curative therapeutics, respiratory cares like home ventilation and prevention of respiratory complications, in a systematic and organized way, allowed to decrease the morbidity and the mortality of these patients. It is not exceptional to meet patients with life expectancy of which overtakes about forty. Besides axial stabilization, cough assistance techniques and swallowing disorders management need to be associated to mechanical ventilation. Invasive techniques of ventilation as tracheostomy keep their place in this pathology even if alternative techniques allowing full day non-invasive ventilation were generalized these last years.

PMID: 26773587 [PubMed - as supplied by publisher]

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Prevalence and Clinical Characteristics of Mycobacterial Diseases in the Barletta-Andria-Trani Province, Italy (2005–2013)

Tuberculosis remains one of the major worldwide problems regarding public health. This study evaluates the burden of this disease in the BAT Province of the Apulia region (Italy); 12,295 patients were studied, including 310 immigrants. Tubercular disease and mycobacteriosis were found in 129 patients. The number of new TB cases/year ranged from three in 2005 to 12 in 2009. TB was more frequently localized in the lung (70.5%). 14.4% of cases were institutionalized patients for severe neurological and/or psychiatric disease. The database evidenced certain aspects of our study population: the large number of TB patients institutionalized between natives, but no larger presence of TB among HIV-positive patients in immigrants compared to Italians. Our findings should help to redefine the alarm regarding the spread of an epidemical form of TB but also to present certain criticisms regarding patient management (especially immigrants) regarding costs, hospitalization, and difficulty of reinstating the patient in the community. Further our data underscore the importance of prevalence of TB in bedridden, institutionalized patients.

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The Subcellular Localization and Functional Analysis of Fibrillarin2, a Nucleolar Protein in Nicotiana benthamiana

Nucleolar proteins play important roles in plant cytology, growth, and development. Fibrillarin2 is a nucleolar protein of Nicotiana benthamiana (N. benthamiana). Its cDNA was amplified by RT-PCR and inserted into expression vector pEarley101 labeled with yellow fluorescent protein (YFP). The fusion protein was localized in the nucleolus and Cajal body of leaf epidermal cells of N. benthamiana. The N. benthamiana fibrillarin2 (NbFib2) protein has three functional domains (i.e., glycine and arginine rich domain, RNA-binding domain, and α-helical domain) and a nuclear localization signal (NLS) in C-terminal. The protein 3D structure analysis predicted that NbFib2 is an α/β protein. In addition, the virus induced gene silencing (VIGS) approach was used to determine the function of NbFib2. Our results showed that symptoms including growth retardation, organ deformation, chlorosis, and necrosis appeared in NbFib2-silenced N. benthamiana.

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Characteristics of phenotypes of elderly patients with asthma

Publication date: Available online 16 January 2016
Source:Allergology International
Author(s): Hiroyuki Sano, Takashi Iwanaga, Osamu Nishiyama, Akiko Sano, Yuji Higashimoto, Katsuyuki Tomita, Yuji Tohda
BackgroundThe characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify associations between clinical characteristics and phenotypes.MethodsA cross-sectional study was conducted in 165 elderly patients (>65 years of age) who underwent a multidimensional assessment of clinical and functional status and comorbidity. The patients were divided into three phenotypes: (1) asthma-predominant, (2) asthma-obstructive airway disease (OAD) overlap without emphysema, and (3) asthma-OAD overlap with emphysema (asthma-emphysema overlap) based on chest HRCT. A receiver operating characteristic (ROC) curve was constructed to evaluate the cutoff for differentiating between the two OAD phenotypes. Multivariate analysis was also used to distinguish between these two phenotypes.ResultsThe phenotypes were asthma-predominant in 48 patients (29%), asthma-OAD without emphysema in 36 (22%), and asthma-emphysema in 81 (49%). Patients with asthma-emphysema were more frequent smokers. In multivariate analysis, smoking status (odds ratio 2.92: 95% CI 1.21–7.00, P = 0.03) and % predicted FEV1 ≤70% (odds ratio 3.18: 95% CI 1.13–8.92, P = 0.03) differed significantly between the asthma-emphysema and asthma-OAD without emphysema phenotypes.ConclusionsHalf of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema.



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Effect of imatinib on growth of experimental endometriosis in rats.

Effect of imatinib on growth of experimental endometriosis in rats.

Eur J Obstet Gynecol Reprod Biol. 2015 Dec 25;197:159-163

Authors: Yildiz C, Kacan T, Akkar OB, Karakus S, Seker M, Kacan SB, Ozer H, Cetin A

Abstract
OBJECTIVE: Currently, medical and surgical treatment options for endometriosis are limited due to suboptimal efficacy, and also safety and tolerance issues. Long-term use of gonadotrophin-releasing hormone analogs, androgenes, and the danazol, which are widely used drugs for endometriosis, is usually not possible due to their suboptimal safety and tolerance profile. The lack of an effective, tolerable and safe treatment option for endometriosis makes animal models of experimental endometriosis necessary to study candidate drugs. The aim of this study was to investigate the efficacy of imatinib on the experimental endometriosis in a rat model.
STUDY DESIGN: Endometriosis was induced by autotransplantation of uterine tissue into the peritoneal cavity. Twenty-four rats, which had visually confirmed endometriotic implants on subsequent laparotomy, were randomized into three groups to receive imatinib (25mg/kg/day, p.o.), anastrozole (0.004mg/day, p.o.), or normal saline (0.1mL, i.p.) for 14 days. After removal of endometriotic tissue and H & E staining, endometriosis score was determined according to a semiquantitative histological classification. Also, immunostaining with primary antibodies including VEGF, CD117, and Bax were used for immunohistochemical (IHC) examination.
RESULTS: Both anastrozole and imatinib suppressed the growth of endometriotic tissue and reduced the number of ovarian follicles. Although the difference was not statistically significant, imatinib was less effective than anastrozole for treatment of endometriosis.
CONCLUSION: Imatinib effectively treats experimental endometriosis by its inhibitor effects on angiogenesis and cell proliferation.

PMID: 26773307 [PubMed - as supplied by publisher]

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Angiotensin System Inhibitors in Renal Cell Carcinoma-Letter.

Angiotensin System Inhibitors in Renal Cell Carcinoma-Letter.

Clin Cancer Res. 2016 Jan 15;22(2):524

Authors: Huillard O, Xylinas E, Peyromaure M, Alexandre J, Goldwasser F

PMID: 26773163 [PubMed - as supplied by publisher]

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Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.

Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.

Genes Dev. 2016 Jan 15;30(2):220-232

Authors: Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA

Abstract
Proteases are important for regulating multiple tumorigenic processes, including angiogenesis, tumor growth, and invasion. Elevated protease expression is associated with poor patient prognosis across numerous tumor types. Several multigene protease families have been implicated in cancer, including cysteine cathepsins. However, whether individual family members have unique roles or are functionally redundant remains poorly understood. Here we demonstrate stage-dependent effects of simultaneously deleting cathepsin B (CtsB) and CtsS in a murine pancreatic neuroendocrine tumor model. Early in tumorigenesis, the double knockout results in an additive reduction in angiogenic switching, whereas at late stages, several tumorigenic phenotypes are unexpectedly restored to wild-type levels. We identified CtsZ, which is predominantly supplied by tumor-associated macrophages, as the compensatory protease that regulates the acquired tumor-promoting functions of lesions deficient in both CtsB and CtsS. Thus, deletion of multiple cathepsins can lead to stage-dependent, compensatory mechanisms in the tumor microenvironment, which has potential implications for the clinical consideration of selective versus pan-family cathepsin inhibitors in cancer.

PMID: 26773004 [PubMed - as supplied by publisher]

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4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells.

4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells.

Biochem Biophys Res Commun. 2016 Jan 7;

Authors: Zhang F, Wan F, Li Z, Fu M

Abstract
The aim of the present study is to investigate the potential anti-hepatocellular carcinoma (HCC) cell activity by 4SC-202, a novel class I HDAC inhibitor (HDACi). The associated signaling mechanisms were also analyzed. We showed that 4SC-202 treatment induced potent cytotoxic and proliferation-inhibitory activities against established HCC cell lines (HepG2, HepB3, SMMC-7721) and patient-derived primary HCC cells. Further, adding 4SC-202 in HCC cells activated mitochondrial apoptosis pathway, which was evidenced by mitochondrial permeability transition pore (mPTP) opening, cytochrome C cytosol release and caspase-3/-9 activation. Inhibition of this apoptosis pathway, by caspase-3/-9 inhibitors, mPTP blockers, or by shRNA-mediated knockdown of cyclophilin-D (Cyp-D, a key component of mPTP), significantly attenuated 4SC-202-induced HCC cell death and apoptosis. Reversely, over-expression of Cyp-D enhanced 4SC-202's sensitivity in HCC cells. Further studies showed that 4SC-202 induced apoptosis signal-regulating kinase 1 (ASK1) activation, causing it translocation to mitochondria and physical association with Cyp-D. This mitochondrial ASK1-Cyp-D complexation appeared required for mediating 4SC-202-induced apoptosis activation. ASK1 stable knockdown by targeted-shRNAs largely inhibited 4SC-202-induced mPTP opening, cytochrome C release, and following HCC cell apoptotic death. Together, we suggest that 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to potently inhibit human HCC cells.

PMID: 26773495 [PubMed - as supplied by publisher]

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Tissue composition regulates distinct viscoelastic responses in auricular and articular cartilage.

Tissue composition regulates distinct viscoelastic responses in auricular and articular cartilage.

J Biomech. 2015 Dec 29;

Authors: Nimeskern L, Utomo L, Lehtoviita I, Fessel G, Snedeker JG, van Osch GJ, Müller R, Stok KS

Abstract
It is well-accepted that articular (ART) cartilage composition and tissue architecture are intimately related to mechanical properties. On the other hand, very little information about other cartilage tissues is available, such as elastin-rich auricular (AUR) cartilage. While thorough investigation of ART cartilage has enhanced osteoarthritis research, ear cartilage reconstruction and tissue engineering (TE) could benefit in a similar way from in-depth analysis of AUR cartilage properties. This study aims to explore the constituent-function relationships of AUR cartilage, and how elastin influences mechanical behavior. Stress-relaxation indentation and tensile tests were performed on bovine ART and AUR cartilage. Elastase incubation was performed to simultaneously deplete elastin and sulfated glycosaminoglycans (sGAG), while hyaluronidase incubation was used to deplete sGAG-only, in order to systematically investigate matrix components in material behavior. ART and AUR cartilages showed different viscoelastic behaviors, with AUR cartilage exhibiting a more elastic behavior. Higher equilibrium properties and limited viscous dissipation of strain energy were observed in AUR cartilage, while ART cartilage exhibited a rapid viscous response and high resistance to instantaneous loading. In conclusion, loss of sGAG had no effect on auricular mechanics in contrast to articular cartilage where GAG loss clearly correlated with mechanical properties. Auricular cartilage without elastin lost all compressive mechanical integrity, whereas in articular cartilage this was provided by collagen. This work shows for the first time the involvement of elastin in the mechanical behavior of ear cartilage. In future, this data can be used in AUR cartilage TE efforts to support reproduction of tissue-specific mechanical properties.

PMID: 26772799 [PubMed - as supplied by publisher]

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Bevacizumab safety in Japanese patients with colorectal cancer.

Bevacizumab safety in Japanese patients with colorectal cancer.

Jpn J Clin Oncol. 2016 Jan 15;

Authors: Hatake K, Doi T, Uetake H, Takahashi Y, Ishihara Y, Shirao K

Abstract
BACKGROUND: Bevacizumab (Avastin(®)) was approved in Japan in April 2007 for patients with advanced or metastatic colorectal cancer. To address the limited clinical experience in Japanese patients, a post-approval surveillance study was undertaken in bevacizumab-treated patients in Japan.
METHODS: Bevacizumab (5 or 10 mg/kg every 2 weeks) was administered with chemotherapy; patients were observed for 26 weeks from initiation of treatment. The primary objective was to investigate the incidence of adverse drug reactions, particularly those of interest for bevacizumab. Univariate and multivariate analyses were performed to identify potential risk factors for adverse drug reactions.
RESULTS: In total, 2712 patients were registered and 2696 patients were included in the safety analysis. Hypertension (13.1%), hemorrhage (10.5%) and proteinuria (4.5%) were the most common adverse drug reaction. The incidences of serious adverse drug reactions were low: gastrointestinal perforation occurred in 0.9% of patients, hemorrhage in 1.3%, arterial thromboembolic events in 0.3%, venous thromboembolic events in 1.3% and wound-healing complications in 0.4%. The incidence of bevacizumab-specific adverse drug reactions was not influenced by the bevacizumab dose. Multivariate analyses identified risk factors for the following adverse drug reactions: hypertension (prior/concurrent hypertension); tumor-associated bleeding (performance status, prior/concomitant anticoagulant or nonsteroidal anti-inflammatory drug use); proteinuria (sex, performance status, prior/concurrent diabetes and proteinuria); gastrointestinal perforation (primary tumor in situ, concurrent nonsteroidal anti-inflammatory drug use); venous thromboembolic event (treatment stage, port insertion).
CONCLUSIONS: The safety profile of bevacizumab-containing regimens in this Japanese population was comparable with studies performed in Western countries. Bevacizumab is generally well tolerated in Japanese patients with advanced or metastatic colorectal cancer.

PMID: 26774113 [PubMed - as supplied by publisher]

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Vegetable and Fruit Acceptance during Infancy: Impact of Ontogeny, Genetics, and Early Experiences.

Vegetable and Fruit Acceptance during Infancy: Impact of Ontogeny, Genetics, and Early Experiences.

Adv Nutr. 2016 Jan;7(1):211S-219S

Authors: Mennella JA, Reiter AR, Daniels LM

Abstract
Many of the chronic illnesses that plague modern society derive in large part from poor food choices. Thus, it is not surprising that the Dietary Guidelines for Americans, aimed at the population ≥2 y of age, recommends limiting consumption of salt, fat, and simple sugars, all of which have sensory properties that we humans find particularly palatable, and increasing the variety and contribution of fruits and vegetables in the diet, to promote health and prevent disease. Similar recommendations may soon be targeted at even younger Americans: the B-24 Project, led by the US Department of Health and Human Services and the USDA, is currently evaluating evidence to include infants and children from birth to 2 y of age in the dietary guidelines. This article reviews the underinvestigated behavioral phenomena surrounding how to introduce vegetables and fruits into infants' diets, for which there is much medical lore but, to our knowledge, little evidence-based research. Because the chemical senses are the major determinants of whether young children will accept a food (e.g., they eat only what they like), these senses take on even greater importance in understanding the bases for food choices in children. We focus on early life, in contrast with many other studies that attempt to modify food habits in older children and thus may miss sensitive periods that modulate long-term acceptance. Our review also takes into consideration ontogeny and sources of individual differences in taste perception, in particular, the role of genetic variation in bitter taste perception.

PMID: 26773029 [PubMed - as supplied by publisher]

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Peroral endoscopic myotomy: first human experience with a water-jet assisted triangle knife.

Peroral endoscopic myotomy: first human experience with a water-jet assisted triangle knife.

Gastrointest Endosc. 2016 Jan 6;

Authors: Balassone V, Sumi K, Inoue H

PMID: 26772890 [PubMed - as supplied by publisher]

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Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway

Publication date: March 2016
Source:International Immunopharmacology, Volume 32
Author(s): Ting-Ting Di, Zhi-Tong Ruan, Jing-Xia Zhao, Yan Wang, Xin Liu, Ying Wang, Ping Li
The flavonoid astilbin is the major active component extracted from the rhizome of Smilax glabra, which has been widely used in China to treat inflammatory and autoimmune diseases, Psoriasis is a common chronic inflammatory disease in which T helper 17 (Th17) cells play an important role, provoking inflammation. We employed an imiquimod (IMQ)-induced psoriasis-like mouse model to investigate the effect of astilbin in inflammation. Mice were administered 25 to 50mg/kg astilbin. Inflammation of psoriasis-like lesions was assessed by histology, circulating levels of T cells were assessed by flow cytometry and cytokines by bead-based immunoassay. Jak/Stat3 in isolated T cells was assessed by Western blotting and RORγt expression was assessed by RT-PCR. Administration of astilbin ameliorated IMQ-induced keratinocyte proliferation, infiltration of CD3+ cells to psoriatic lesions and ameliorated elevations in circulating CD4+ and CD8+ T cells and inflammatory cytokines (IL-17A, TNF-α, IL-6, IFN-γ and IL-2). In vitro, astilbin inhibited Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibited Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Thus, astilbin likely alleviates psoriasis-like skin lesions by inhibiting Th17 related inflammation. Astilbin represents as an interesting candidate drug for immunoregulation of psoriasis.



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Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type.

Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type.

Genes Chromosomes Cancer. 2016 Jan 16;

Authors: Dobashi A, Tsuyama N, Asaka R, Togashi Y, Ueda K, Sakata S, Baba S, Sakamoto K, Hatake K, Takeuchi K

Abstract
Extranodal natural killer/T cell lymphoma (ENKTL) is a rare subtype of lymphoma. Recurrent mutations in the JAK-STAT pathway, recently reported in ENKTL cases, are interesting in terms of both pathogenesis and inhibitor therapy. However, the frequencies of these mutations are low and variable among reports, and other pathognomonic mutations in ENKTL remain to be elucidated. In the present study, we performed targeted capture sequencing of 602 cancer-related genes from 25 frozen ENKTL samples, 11 of which were matched to normal samples. We identified several recurrent somatic mutations involving BCOR (32%), TP53 (16%), DDX3X (12%), FAT4 (8%), NRAS (8%), MLL3 (12%) and MIR17HG (8%). The pattern of BCOR aberrations (1 nonsense and 5 frame-shift mutations, a mutation leading to a splicing error, and gene loss) suggested that loss of function of BCOR was the functionally important outcome of such changes. We reviewed the literature and reanalyzed the public data on BCOR aberrations and found that the aberrations were frequently found in myeloid neoplasms, but, interestingly, were highly specific to ENKTL among lymphoid malignancies. Given the high frequency and pattern of aberration, BCOR is likely to play an important role in ENKTL pathogenesis as a tumor suppressor gene. This article is protected by copyright. All rights reserved.

PMID: 26773734 [PubMed - as supplied by publisher]

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Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: transformation into a neoplastic-like phenotype

Publication date: Available online 16 January 2016
Source:Free Radical Biology and Medicine
Author(s): Cinzia Antognelli, Angela Gambelunghe, Giacomo Muzi, Vincenzo Nicola Talesa
Glyoxalase I (Glo1) is the main scavenging enzyme of methylglyoxal (MG), a potent precursor of advanced glycation endproducts (AGEs). AGEs are known to control multiple biological processes, including epithelial to mesenchymal transition (EMT), a multistep phenomenon associated with cell transformation, playing a major role in a variety of diseases, including cancer. Crystalline silica is a well-known occupational health hazard, responsible for a great number of human pulmonary diseases, such as silicosis. There is still much debate concerning the carcinogenic role of crystalline silica, mainly due to the lack of a causal demonstration between silica exposure and carcinogenesis. It has been suggested that EMT might play a role in crystalline silica-induced lung neoplastic transformation. The aim of this study was to investigate whether, and by means of which mechanism, the antiglycation defence Glo1 is involved in Min-U-Sil 5 (MS5) crystalline silica-induced EMT in BEAS-2B human bronchial epithelial cells chronically exposed, and whether this is associated with the beginning of a neoplastic-like transformation process. By using gene silencing/overexpression and scavenging/inhibitory agents, we demonstrated that MS5 induced hydrogen peroxide-mediated c-Jun-dependent Glo1 up-regulation which resulted in a decrease in the Argpyrimidine-modified Hsp70 protein level which triggered EMT in a novel mechanism involving miR-21 and SMAD signalling. The observed EMT was associated with a neoplastic-like phenotype. The results obtained provide a causal in vitro demonstration of the MS5 pro-carcinogenic transforming role and more importantly they provide new insights into the mechanisms involved in this process, thus opening new paths in research concerning the in vivo study of the carcinogenic potential of crystalline silica.



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Activation of classical estrogen receptor subtypes reduces tight junction disruption of brain endothelial cells under ischemia/reperfusion injury

Publication date: Available online 16 January 2016
Source:Free Radical Biology and Medicine
Author(s): Jin A. Shin, Joo Chun Yoon, Min-Suk Kim, Eun-Mi Park
Ischemic stroke, which induces oxidative stress in the brain, disrupts tight junctions (TJs) between brain endothelial cells, resulting in blood-brain barrier (BBB) breakdown and brain edema. Estrogen reduces oxidative stress and protects brain endothelial cells from ischemic insult. The aim of this study was to determine the protective effects of estrogen on TJ disruption and to examine the roles of classical estrogen receptor (ER) subtypes, ERα- and ERβ, in estrogen effects in brain endothelial cells (bEnd.3) exposed to oxygen-glucose deprivation/reperfusion (OGD/R) injury. Estrogen pretreatment prevented OGD/R-induced decreases in cell viability and TJ protein levels. ERα- and ERβ-specific agonists also reduced TJ disruption. Knockdown of ERα or ERβ expression partially inhibited the effects of estrogen, but completely reversed the effects of corresponding ER subtype-specific agonists on the outcomes of OGD/R. During the early reperfusion period, activation of extracellular signal-regulated kinase1/2 and hypoxia-inducible factor 1α/vascular endothelial growth factor was associated with decreased expression of occludin and claudin-5, respectively, and these changes in TJ protein levels were differentially regulated by ER subtype-specific agonists. Our results suggest that ERα and ERβ activation reduce TJ disruption via inhibition of signaling molecules after ischemic injury and that targeting each ER subtype can be a useful strategy for protecting the BBB from ischemic stroke in postmenopausal women.

Graphical abstract

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Diet and Feeding Behavior of Leontopithecus chrysomelas (Callitrichidae) in Degraded Areas of the Atlantic Forest of South-Bahia, Brazil

Abstract

Habitat disturbance alters plant diversity and food resource availability, affecting the ecology, and ultimately the survival and reproduction, of species depending on those plants. Studies in degraded areas serve to improve our understanding of the consequences of habitat modification for endangered species and to guide conservation actions. We studied diet composition, monthly variation in feeding behavior and fruit feeding time, and dietary diversity in two golden-headed lion tamarin (Leontopithecus chrysomelas) groups ranging in a degraded area of the Atlantic Forest in South-Bahia, Brazil, over a 12-mo period. We recorded feeding behavior and food items consumed through continuous observations and focal animal sampling, and performed dietary analyses on samples from consumed fruits. Substrate manipulation to search for animal prey was the feeding activity most frequently observed, followed by fruit consumption. We observed nectar drinking and exudate feeding at low frequencies from April through July. Bromeliads were the principal foraging substrate. We observed the use of 114 plant species, confirming the large dietary diversity reported for the species. Individual trees from the family Melastomataceae, common in degraded forests, accounted for the highest visiting frequencies (40%). Fruit availability was the main factor explaining variation in monthly fruit feeding time, despite the absence of climatic seasonality. Nutritional or energetic characteristics did not affect fruit choice. Differences in floristic composition appear to be a major determinant of the species' diet in different study areas. Regional forest restoration programs should consider including advanced forest species, to improve both forest quality and animal mobility between fragments.

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Joint Assessment of Bioreduction of Chromium(VI) and of Removals of Both Total Chromium and Total Organic Carbon (TOC) in Sequential Hybrid Bioreactors

Abstract

The overall purpose of this work was to evaluate the treatment system performance of sequential hybrid bioreactors, one without aeration and another with intermittent aeration, in the bioremoval of Cr(VI) and total chromium and in the removal of total organic carbon (TOC). The saturation kinetic curves were studied with initial concentrations of Cr(VI) of 80, 120 and 150 mg L⁻¹. A reference test was performed before adding chromium to the system, with the intention of checking the influence of the presence of chromium on the TOC removal. During the bioreactor regeneration, the chromium removal was evaluated, after each kinetic studied. For kinetics with 80 mg L⁻¹ of Cr(VI), the results showed that after 600 h of operation, there was no saturation of bioreactors, yielding 87 % overall removal of Cr(VI) and 62 % chromium total. For initial concentrations of Cr(VI) of 120 and 150 mg L⁻¹, only the non-aerated bioreactor reached saturation after 228 and 216 h of operation, respectively. In regeneration, it was found in all the assays performed that the chromium concentration at the outlet of the bioreactor became almost zero at a maximum of 72 h of operation. In the blank test, the TOC removal achieved was 64 %, while in the three tests in the presence of chromium, this was approximately 55 % (80 mg L⁻¹), 41 % (120 mg L⁻¹) and 31 % (150 mg L⁻¹). After cell lysis by ultrasound, it was found that the chromium concentration retained inside there was lower than the concentrations present in the environment.

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Mercury in marine fish, mammals, seabirds, and human hair in the coastal zone of the southern Baltic

Abstract

Mercury (Hg), aside from having high toxicity, is characterized by its ability to biomagnify in the marine trophic chain. This is an important problem especially in estuaries, or in the coastal zone, particularly near the mouths of large rivers. This study was conducted in the years 2001–2011, in the coastal zone of the Baltic Sea near to the mouth of the River Vistula, which is the second biggest river discharging into the Baltic. Mercury concentration was measured in the tissues and organs of cod, flounder, herring, seals (living in the wild and in captivity), great black-backed gulls, and African penguins from Gdańsk Zoo, and also in human hair. Penguins and seals at the seal sanctuary in Hel were fed only herring. In marine birds and mammals and in the pelagic herring, the highest Hg concentration was observed in the kidney and in the liver, while in cod and flounder (located on a higher trophic level) the muscles were the most contaminated with mercury. In gray seals living in the seal sanctuary, Hg concentration in all analyzed tissues and organs except the kidneys was lower in comparison with seals living in the wild. The comparatively small share of fish in the diet of local Polish people and their preference towards the consumption of herring contributed to low concentration of Hg in their hair. The protective mechanisms related to detoxification and elimination of mercury were shown to be more effective in the seals than in the penguins, despite the former consuming around 10 times more food per day.

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Influence of Abiotic Factors on the Spatio-temporal Distribution of Rotifers in a Subtropical Lake of Western Himalaya

Abstract

Spatial and temporal variation of rotifers in Lake Sattal of Western Himalaya was studied from January 2011 to December 2012. A total of 22 rotifer species could be identified in the lake with a biannual mean abundance of 2.07 × 10⁶ individuals/m³ in eastern basin and 1.92 × 10⁶ individuals/m³ in western basin having maximum abundance during summer season. The main factors regulating distribution patterns of rotifers are nutrients, viz. NH₄-N, PO₄-P, NO₂-N, and NO₃-N, and turbidity, pH, and transparency. Six species of rotifers were deliberated as important species based on importance value index. Keratella quadrata, Colurella obtusa, and Asplanchna priodonta flourish under low turbid conditions. Philodina roseola demonstrated as a phosphorous-tolerant species, whereas K. quadrata and C. obtusa are thermophilous and their distributions are highly influenced by pH and transparency. The total organic matter (TOM) of the sediment has a significant positive correlation with species richness and diversity. The hierarchical environmental descriptor suggests water chemistry has a greater significant role in assemblages of rotifers as compared to sediment characteristics.

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Fwd: Jiangsu Pharmacertical and Clinical Research, Year 2015, Issue 06 -New Issue Alert.

From: order@email.oriprobe.com

Date: January 17, 2016 at 08:05AM

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Jiangsu Pharmacertical and Clinical Research. Year 2015 Issue 06 is now available on CAOD. In this issue: 2015 nian yao xue yu lin chuang yan jiu zong mu lu (2015年《药学与临床研究》总目录) ...... page:1-4 Study on the Concept of Antibiotics Density Impact Factor and Its Application (抗菌药物使用强度影响因子的概念及应用) LU Yu, SI Liang-hong, LIU Zi-xiu, LI Rui-jun, ZHU Yuan-yuan, No.454 Hospital of PLA ...... page:535-538 An UPLC/MS/MS Method for Simultaneous Determination of Losartan, Amlodipine and Simvastatin in Human Plasma (UPLC-MS/MS法同时测定人血浆中氯沙坦、氨氯地平和辛伐他汀的浓度) LI San-ni, ZHANG Gu-ying, HAN Hua, Children's Hospital of Hebei Province, Hebei General Hospital ...... page:539-542 Simultaneous Determination of Five Components in Zhiling Junsi Capsules by LC-MS (LC-MS法同时测定至灵菌丝胶囊中5种成分的含量) ZHANG Xian-lin, DAI Guo-liang, DING Kang, GONG Tao, CHEN Zhi-yuan, JU Wen-zheng, Department of Pharmacy, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Department of Clinical Pharmacology, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, First School of Clinical Medicine, Nanjing University of TCM ...... page:543-545 Dissolution Evaluation of Metoprolol Tartrate Tablets (国产酒石酸美托洛尔片的溶出度质量评价) YAN Fei, CAI Mei-ming, LI Zhong-hong, CHEN Min-hui, Jiangsu Institute for Food and Drug Control ...... page:546-548 Rapid Identification of Counterfeit Tienam with Mobile Labs (泰能真伪的快速鉴别) JIN Peng, YANG Bo, ZHANG Shu, Jiangsu Huaian Institute for Food and Drug Control, Jiangsu Huaian Food and Drug Administration ...... page:549-551 Effects of Desloratadine on the Expression of IL-4 Receptor mRNA in Lung Tissues of Allergic Asthma Guinea Pig (地氯雷他定对过敏性哮喘豚鼠模型肺组织IL-4R mRNA表达的影响) ZHANG Li, BAI Ru-qin, Depatment of Pharmacy, Nanjing Chest Hospital, Department of Pharmacy, Jiangsu Province Hospital of TCM ...... page:552-554 Optimization of the Preparation of Itopride Hydrochloride Dispersible Tablet Using Response Surface Methodology (星点设计法优化盐酸伊托必利分散片处方) YUE Li, WANG Jiang-tao, LONG Lian-qing, SU Liang, DiSha Pharmaceutical Group ...... page:555-557 Determination of Paraquat in Plasma by Reversed Phase Ion-pair HPLC (离子对反相高效液相色谱法测定百草枯血药浓度) ZHANG Hong-wen, YIN Zhi-yang, LIU Qiang-hui, CAO Yang, WANG Yu-qing, WANG Yong-qing, OU Ning, MENG Ling, ZHANG Jing-song, Department of Pharmacy, the First Affiliated Hospital of Nanjing Medical University, Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, College of Pharmacy, Nanjing Medical University ...... page:558-561 An HPLC Method for the Determination of Hydroxychloroquine in Both Serum and Blood Samples and Its Application in SLE Patients (全血及血清中羟氯喹HPLC测定方法的建立及其应用) LUO Xue-mei, SI Hui-min, YAO Yao, GE Wei-hong, Department of Medication, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Department of Rheumatology, the Affiliated Drum Tower Hospital of Nanjing University Medical School ...... page:562-564 An HPLC-FLD Method for the Determination of Irinotecan and Its Metabolites SN-38 and SN-38G in Plasma (HPLC法测定血浆中伊立替康及其代谢产物SN-38、SN-38G浓度及方法学研究) WANG Wan-qing, HUANG Chen-rong, Department of Pharmacy, the First Affiliated Hospital of Soochow University, Department of Clinical Pharmacology, the First Affiliated Hospital of Soochow University ...... page:565-568 Determination of Content of Succimer in Kit for Preparation of Technetinm[99mTc] Succimer Injection by HPLC (HPLC法测定注射用亚锡二巯丁二钠中二巯丁二酸的含量) WANG Yang, CHEN Zhi-ming, WU Er-ming, WANG Gang, LIU Jia-lin, Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine ...... page:569-570 Determination of Cholalic Acid and Hyodeoxycholic Acid in Ganyu Capsules by HPLC-ELSD (HPLC-ELSD法同时测定感愈胶囊中胆酸和猪去氧胆酸的含量) WANG Lei, QIU Qi-yuan, Yancheng Institute for Drug Control ...... page:571-572 Progress in Clinical Application of Azilsartan (阿齐沙坦的临床应用进展) ZOU Shou-tao, QIN Jian, Department of Pharmacy, the First Affiliated Hospital of Changsha Medical University ...... page:573-575 chui ti hou ye su lian he xian zhi xing shu ye zai zhi liao gan ying hua he bing shang xiao hua dao da chu xue de ying yong xiao guo (垂体后叶素联合限制性输液在治疗肝硬化合并上消化道大出血的应用效果) JI Zuo, ZHANG Xia, YAN Zhengping ...... page:576-577 Staged Adjustment Mode of Antimicrobial Regimen for Acute Kidney Injury Patients with Pulmonary Infection (急性肾损伤并肺部感染患者的抗菌方案阶段性调整探析) CHEN Yao, SONG Xiang-qing, Department of Pharmacy, Loudi Central Hospital, Department of Pharmacy, Hunan Cancer Hospital ...... page:578-580 Clinical Application Investigation and Rationality Analysis of Human Serum Albumin (人血白蛋白临床应用调查及合理性分析) HANG Yong-fu, ZHENG Xiao-xian, ZHANG Yan, LI Yun, QIN Qiong, GONG Xiao-ying, BAO Jian-an, JIN Hong-bin, Department of Pharmacy, the First Affiliated Hospital of Soochow University ...... page:581-583 Individualized Pharmaceutical Care for a Patient with Hepatic Cirrhosis Complicated with Other Diseases (对1例肝硬化并发多种疾病患者的个体化药学监护) XU Lu, ZHOU Xing-bei, WU Qian-hu, YAN Jin-er, ZOU Sheng-qiang, ZHU Xiao-lei, YU Ai-xia, WEI Yuan, Department of Pharmacy, the Third People's Hospital of Zhenjiang City in Jiangsu, Department of Liver Disease, the Third People's Hospital of Zhenjiang City in Jiangsu, Drug Clinical Trial Institution Office, the Third People's Hospital of Zhenjiang City in Jiangsu, Office of Vice Director, the Third People's Hospital of Zhenjiang City in Jiangsu, School of Pharmacy, Jiangsu University ...... page:584-586 Analysis of Anticoagulant Therapy for a Patient after Mechanical Heart Valve Replacement (1例心脏病术后患者华法林抗凝治疗的用药分析) WU Xiao-li, ZHOU Ling, Department of Pharmacy, Huai'an First People's Hospital, Department of Pharmacy, the First Affiliated Hospital of Suzhou University ...... page:587-589 Analysis of Adverse Reaction Caused by Compound Amino Acid Injections (复方氨基酸注射液1540例不良反应的综合分析) LI Ming, MA Dan-hua, FENG Dan-yu, SUN Jun, Center for ADR monitoring of Jiangsu, China Pharmaceutical University ...... page:590-592 Analysis of 519 Reports of Suspicious Adverse Events Associated with In Vitro Diagnostics(IVD) Medical Devices (体外诊断试剂519例可疑不良事件报告分析) LI Yao, WANG Xin-min, BIAN Rong-rong, SUN Jun, ZHANG Su-lin, Center for ADR Monitoring of Jiangsu, Center for Certification & Evaluation, Jiangsu Food and Drug Administration ...... page:593-595 Analysis of Out-label Prescriptions in Cancer Therapy (肿瘤治疗超说明书用药案例分析) CAI Ning, Jiangsu Cancer Hospital ...... page:596-598 Pharmaceutical Care on Voriconazole Raised Tacrolimus Blood Concentration in a Renal Transplant Patient (伏立康唑致1例肾移植患者他克莫司血药浓度升高) CHEN Jin, GAO Jie, Department of Pharmacy, Haian County People's Hospital of Jiangsu Province, Department of Pharmacy, the First Affiliated Hospital of Soochow University ...... page:599-600 2015 nian 11 yue mei guo fda gong bu de yao pin an quan xin xi (2015年11月美国FDA公布的药品安全信息) ...... page:600+610 te li pa zuo zhi guo min xing xiu ke 1 li (特立帕肽致过敏性休克1例) CAI Ying ...... page:601 Evaluation of Strict Antibiotic Restriction Policy on Clinical Application of Antibacterials in Secondary and Tertiary Hospitals from 2011 to 2013 in Yangzhou (2011～2013年扬州市二、三级医院抗菌药物专项整治活动实施效果评价) SHU Yu-sheng, ZHU Hua, JIA Ling-chang, XU Jian-guo, SHAO Jian-ping, Northern People's Hospital of Jiangsu Province ...... page:602-605 Analysis of 63 Adverse Reactions of Traditional Chinese Medicine Preparations (中药制剂63例不良反应分析) ZHAI Hong-fa, Pharmacy of Danyang Traditional Chinese Medicine Hospital ...... page:606-607 Property and Rational Use of Common Eye-drops (常见滴眼液的特性及合理应用) YE Ting, ZHU Xiao-min, CHENG Ying-ying, WU Hong-yun, Department of Ophthalmology, Nanjing General Hospital of Nanjing Military Command PLA ...... page:608-610 Introduce of the Pharmacist-participated Inpatient Anticoagulation Management Services in America (美国药师参与住院抗凝管理的服务模式) LIN Xin, XU Rui-juan, GE Wei-hong, College of Pharmaceutical Sciences, China Pharmaceutical University, Pharmacy Department of Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School ...... page:611-614 Adverse Drug Reaction Reporting and Monitoring In American Pharmaceutical Manufacturers and Its Implication to China (美国制药企业不良反应报告和监测工作对我国的启示) SHI Qin, YANG Yue, WEI Jing, Shenyang Pharmaceutical University College of Business Administration, Liaoning Center for Certification of Drug ...... page:615-618 Analysis and Strategy Research on the Defects of the Quality System of Chain Pharmacies in Jiangsu Province (江苏省药品零售连锁企业GSP(2013版)认证检查质量缺陷分析及其对策) CAO Jia-cheng, Center for Drug Certification and Evaluation, Jiangsu Food and Drug Administration ...... page:619-622 Roles of Quality Control Circle in Reducing the Number of Intra-variance of Pharmacy Intravenous Admixture Service (品管圈在降低静脉药物配置中心内差中的作用) ZHAO Min, TONG Ben-ding, Jiangsu Cancer Hospital ...... page:623-625 Brief Review on Differentiating Factors for Topical Drug Selections in Skin Disease Treatment (掌握多种差异性 合理使用皮肤外用药) SHEN Guo-qing, Hospital of Dermatology, Chinese Academy of Medical Sciences ...... page:626-628+542 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

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Fwd: China Licensed Pharmacist, Year 2015, Issue 12 -New Issue Alert.

From: order@email.oriprobe.com

Date: January 17, 2016 at 08:05AM

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for China Licensed Pharmacist. Year 2015 Issue 12 is now available on CAOD. In this issue: Application of Antibiotic in Hospitalized Patients before and after Intervention (干预前后我院住院患者抗菌药物使用情况分析) Luo Hong, Siu Lam Hospital of Southern Medical University ...... page:3-7 mei guo fda pi zhun kang jing shen bing yao aripiprazole lauroxil shang shi (美国FDA批准抗精神病药Aripiprazole Lauroxil上市) ...... page:7 Monitoring of Rational Clinical Application of Antibiotics in Patients in ICU (ICU患者抗菌药物临床合理使用监测研究) Zhong Yongji, Liu Weihao, Xiao Yingxia, Xingning People's Hospital ...... page:8-13+17 Bacteriostatic Effect of Schisandra and Jaume on Sixty Strains of Extensively Drug-resistant Acinetobacter baumannii (五味子、乌梅对60株广泛耐药鲍曼不动杆菌的抑菌作用) Wu Xianli, Pang Zaiyuan, Ao Maocheng, Su Deyong, Li Jing, Hua Yi, Central Hospital of Panzhihua City ...... page:14-17 Study on Quality Standard for Compound Breynia Fruticosa Ointment (复方黑面神软膏质量标准研究) Xiao Junqi, Peng Weiwen, Li Shengpeng, Dong Wangfeng, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine ...... page:18-24 grazoprevir lian he elbasvir yong yu ban 4 5 qi man xing shen bing de bing xing gan yan bing du ji yin 1 xing gan ran huan zhe an quan you xiao (Grazoprevir联合Elbasvir用于伴4～5期慢性肾病的丙型肝炎病毒基因1型感染患者安全有效) ...... page:24 Simultaneous Determination of Cinobufagin and Resibufogenin in Dried Toad Skin by HPLC (HPLC同时测定干蟾皮中华蟾酥毒基和酯蟾毒配基成分的含量) Wang Yuanfu, Nanchang Institute for Food and Drug Control ...... page:25-30 Determination of Hesperidin Content in Zhike Qingfei Oral Liquid by HPLC (HPLC测定止咳清肺口服液中橙皮苷的含量) Zhang Yubo, Liu Guangbin, Department of Pharmacy, Jiugang Hospital ...... page:31-33 Influence of Amomum Villosum Lour and Exocarpium Citrl Grandis on Liver CYP3A and Intestinal First Pass Effect in Mice (阳春砂仁和化橘红对小鼠肝脏CYP3A及肠道首过效应的影响) Wang Yonghui, Qi Jinfeng, Lin Mei, Kong Yonghong, Pharmacy Department of Zhumadian Central Hospital, College of Chinese Materia Medica of Guangzhou University of Chinese Medicine ...... page:34-38 mei guo fda pi zhun kang tang niao bing yao insulin degludec and insulin aspart fu fang zhi ji shang shi (美国FDA批准抗糖尿病药Insulin Degludec and Insulin Aspart复方制剂上市) ...... page:38 Comparison and Analysis of Quality Standard for Allopurinol and Its Preparations in Three National Pharmacopoeias (三国药典中别嘌醇及其制剂质量标准的比较分析) Tian Peilin, Gu Qian, Zhou Zhenyu, Liu Huaming, Suzhou Institute for Food and Drug Control ...... page:39-43 Pharmaceutical Care of One Case of Hypophosphatemic Osteomalacia Secondary by Fanconi Syndrome Caused by Adefovir (1例阿德福韦酯致范可尼综合征并继发低磷性骨软化症的药学监护) Zhao Jun, Xin Xiaowei, Zhao Shanshan, Yao Wen, Sui Zhongguo, Pharmacy Department of the Affiliated Hospital of Qingdao University ...... page:44-47 di qi jie zhong guo yao shi da hui zai wu han luo xia zuo mu (第七届中国药师大会在武汉落下帷幕) BEN Kanxun ...... page:47 Key Point of Pharmaceutical Care for Patients with Hypothyroidism in Pregnancy (妊娠合并甲状腺功能减退症的药学服务要点) Wei Xiaoxia, Zhuang Jie, Yang Mei, Sun Hong, Provincial Clinic Medical School of Fujian Medical University, Pharmacy Department of Fujian Provincial Hospital, Pharmacy Department of Cancer Hospital, Chinese Academy of Medical Sciences ...... page:48-49+56 Analysis of 138 Cases of Adverse Drug Reactions in a Hospital (某院138例药品不良反应分析) Li Yao, Liu Xiuqiong, Xu Juan, Gu Hui, The First People's Hospital of Jintang County, Sichuan Province ...... page:50-52 Analytical Report on 21 Cases of ADRs Caused by Prepared Traditional Chinese Medicine (21例中成药不良反应报告分析) Lu Weifeng, Zhi Weiwen, Yunfu Hospital of TCM ...... page:53-56 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. You are receiving this email because you have requested to receive information from CAOD as a registered user of our Table of Content Alert for journals. To manage your TOC Alerts, please click here. For all enquiries, problems or suggestions regarding this service, please contact info@oriprobe.com. China/Asia on Demand (CAOD) Customer Service

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Fwd: Journal of International Pathology and Clinical Medicine, Year 2015, Issue 11 -New Issue Alert.

From: order@email.oriprobe.com

Date: January 17, 2016 at 08:05AM

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Journal of International Pathology and Clinical Medicine. Year 2015 Issue 11 is now available on CAOD. In this issue: ame news|ame 2016 nian bing li tiao zhan sai ests ya zhou dui jing ying dui yuan xuan ba sai shi jian he di dian gong bu (AME News|AME 2016年病例挑战赛ESTS亚洲队精英队员 选拔赛时间和地点公布) LI Shaoling ...... page:1869-1875 ame news| wo guo ke ji gong zuo zhe fa xian chen zuo xin guo min yuan der f 28 (AME News|我国科技工作者发现尘螨新过敏原Der f 28) ZENG Guangqiao ...... page:1876-1877 ame news| jin qiu jie bao :cco cheng wei ame di liu ben bei scopus shou lu de qi kan (AME News|金秋捷报:CCO成为AME第六本被Scopus收录的期刊) HUANG Xiaoman ...... page:1878-1880 itmig 2015| yi lu shang you ni tu shuo 2015 xiong xian zhong liu xie hui nian hui shang hai zhi xing (ITMIG 2015|一路上有你——图说2015胸腺肿瘤协会年会上海之行) LU Xiaoyan, LI Shaoling ...... page:1881-1888 ame zong heng zhuan lan 002| ru he zhi zuo shu ju shou ji biao ge ?so easy! (AME纵横专栏002|如何制作数据收集表格?so easy!) ZHANG Zhongheng ...... page:1889-1891 ame college| yi zuo ( bei jing zhan ) hua xu hui gu : cheng chang lu shang , gan xie you ni (AME College|亦塾(北京站)花絮回顾:成长路上,感谢有你) XU Xiaoyue ...... page:1892-1899 ame news| ji di san jie dong fang xiong wai ke lun tan (AME News|记第三届东方胸外科论坛) ZHONG Shanshan, GAO Fengping ...... page:1900-1903 ame news| ji 2015 astro da hui (AME News|记2015 ASTRO大会) HE Chaoxiu, ZHONG Qinghua ...... page:1904-1908 ame te yao lai gao | xin nian yu meng xiang qi fei , shi zhe yi zai lu shang (AME特邀来稿|信念与梦想齐飞,师者亦在路上) GU Bing ...... page:1909-1910 ame news| si xiang yuan yu peng zhuang , jin bu shi yu jiao liu ji gan dan wai ke ji lun wen xie zuo guo ji yan tao hui (AME News|思想源于碰撞,进步始于交流——记肝胆外科及 论文写作国际研讨会) JIANG Yongshi, XU Xiaoyue ...... page:1911-1915 ame pubmed shi yong ji qiao | san bu zhui zong pubmed zhong mou ling yu zui xin wen xian (AME PubMed实用技巧|三步追踪PubMed中某领域最新文献) CHEN Shuo, MAO Zhi ...... page:1916-1917 ame news|2015 shang hai ru fang zhong jian lun tan cheng gong zhao kai (AME News|2015上海乳房重建论坛成功召开) WANG Jiahui ...... page:1918-1919 ame news| qi fen xiang , tong jiao liu , cu gong jin ji di er jie jian qiao guo ji xiong wai wei chuang shou shu yan tao hui (AME News|齐分享,同交流,促共进——记第二届剑桥国际胸外微创手术研讨会) GAO Fengping, ZHONG Shanshan ...... page:1920-1925 elsa 2015| hui yi jian wen : kai zai li shi wen hua yi chan ming cheng de xue shu zhi hua (ELSA 2015|会议见闻:开在历史文化遗产名城的学术之花) HUANG Chujun ...... page:1926-1929 ame bian ji bu de gu shi | fei cheng jian wen zhi bin xi fa ni ya da xue yi yuan : zhi zi zhi liao zhong xin (AME编辑部的故事|费城见闻之宾夕法尼亚大学医院:质子治疗中心) XU Xiaoyue ...... page:1930-1931 Effects of postoperative cognitive function in the different anesthesia depth for laparoscopic gastrointestinal operation elderly (不同麻醉深度对老年腹腔镜胃肠手术术后认知功能的影响) DONG Nan, PU Yong, JIAN Jinjin, ZHU Yunxia, Department of Anesthesiology, Affiliated Hospital of Jiangnan University, Wuxi No.4 People's Hospital, Department of Pathology, Affiliated Hospital of Jiangnan University, Wuxi No.4 People's Hospital ...... page:1932-1936 Analysis of the distribution and resistance of pathogens isolated cultured from midstream urine in 2014 (2014年中段尿培养病原微生物分布及耐药性分析) BIAN Guangrong, WANG Yan, LIU Genyan, WEN Yi, GU Bing, MEI Yaning, Department of Clinical Laboratory, the Second People's Hospital of Lianyungang, Department of Laboratory Medicine, the First Affiliated Hospital of NJMU, Department of Clinical Laboratory, the Affiliated Hospital of Xuzhou Medical College ...... page:1937-1942 Expression and clinical significance of WIF-1 DNA methylation in hepatic cancer (血浆WIF-1 DNA甲基化与肝癌患者临床特征和预后的关系) LIU Yan, LIU Fan, SHEN Fu, MAO Guoxin, YUAN Xinlu, Department of Oncology, the Affiliated Hospital of Nantong University, Department of Endocrinology, the Affiliated Hospital of Nantong University ...... page:1943-1947 Patients with gastric cancer postoperative enteral nutrition support on body composition and the change of energy metabolism (胃癌术后肠内营养支持对患者人体成分及能量代谢变化的影响) LI Xuejiao, HUANG Yingchun, PENG Nanhai, LIU Sitong, Anhui Bengbu Medical College, Department of General Surgery, Nanjing General Hospital of Nanjing Military Command ...... page:1948-1953 Chronic atrophic gastritis endoscopy and clinical pathological diagnosis comparative study (慢性萎缩性胃炎内镜检查与临床病理诊断对比研究) QIU Xiaodi, PAN Xiangzhen, LIANG Qunying, QIN Zhenzhu, Department of Pathology, Shangqiu First People's Hospital of Henan Province ...... page:1954-1957 Detection of RGC-32 expression in colon cancer and its significance (RGC-32在结肠癌组织中的表达及临床意义) WANG Zaiyan, DING Baijing, Department of Gastroenterology, Wuhu No.2 People's Hospital ...... page:1958-1961 Clinical effect of binocular vision training for amblyopia (双眼视训练治疗弱视的临床效果) WANG Li, LI Chunlin, Department of Ophthalmology, Shaanxi Ankang Central Hospital ...... page:1962-1966 The study on expression of JAK1/STAT1 and its correlation in NSCLC with EGFR exon 19 deletion (JAK1/STAT1在EGFR 19-Del之NSCLC中的表达及其相关性研究) YANG Feng, WANG Lei, ZHONG Daixing, YANG Sanhu, Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University ...... page:1967-1973 The investigation of insulin secretion function of pancreas β cells in poor glucose control type 2 diabetic patients (血糖控制不佳的2型糖尿病患者胰岛β细胞分泌功能的特点研究) YUAN Xinlu, ZHU Xiaohui, CUI Shiwei, Department of Endocrinology, Affiliated Hospital of Nantong University ...... page:1974-1978 ben kan chang yong ci hui ying wen suo xie biao ( an ying wen zi mu pai xu ) (本刊常用词汇英文缩写表(按英文字母排序)) ...... page:1978 Combined application of endometrial collector, liquid based cytology and cell module in screening of endometrial carcinoma and precancerous lesions (子宫内膜采集器、液基细胞学、细胞模块在子宫内膜癌及癌前病变筛查中的联合应用) WANG Yueyuan, SHI Qingfang, ZHOU Qingyun, ZHAO Jie, TIAN Fang, Department of Pathology, Gansu Provincial Maternity and Child-Care Hospital ...... page:1979-1984 Steroids reduces postoperative nausea and vomiting and pain following TKA meta-analysis (静脉应用糖皮质激素改善膝关节置换术后PONV和疼痛的meta分析) YU Lei, ZHANG Chenghuan, BAO Nirong, ZHAO Jianning, Department of Orthopedics, Nanjing General Hospital of Nanjing Military Command, Second Military Medical University, School of Nursing, Nanjing University of Chinese Medicine ...... page:1985-1991 The expression and significance of long non-coding RNA UC001kfo in human breast cancer (长链非编码RNA UC001kfo在乳腺癌组织中的表达及临床意义) HUANG Qiuxia, CHEN Gang, WEI Kanglai, FENG Zhenbo, CHEN Hao, Department of Pathology, the First Affiliated Hospital of Guangxi Medical University ...... page:1992-1998 The influence of cesarean delivery women's mood and quality life by the problem oriented health education (以问题为导向健康教育对剖宫产妇女情绪和生活质量的影响) LI Youxia, YANG Xiurong, WEI Dixia, Department of Gynaecology and Obstetrics, the Second People's Hospital of Hainan Province, Department of Gynaecology and Obstetrics, Haikou City of Hainan Province People's Hospital, Department of Gynaecology and Obstetrics, Sanya City of Hainan Province People's Hospital ...... page:1999-2003 The clinical examination significance of Cys C, vascular endothelial growth factor and levels β2-GPⅠon type 2 diabetic nephropathy (2型糖尿病肾病患者Cys C、血管内皮生长因子和β2-GPⅠ水平的检测及其临床意义) LI Jian, YAN Shuangtong, GONG Yanping, LU Yanhui, SUN Banruo, CHENG Xiaoling, LI Chunlin, SHAO Yinghong, Department of Geriatric Endocrinology, PLA General Hospital ...... page:2004-2008 The progress of HDAC7 and tumor angiogenesis as a theraptic target (HDAC7与肿瘤血管生成及其抗血管靶点治疗的研究进展) LI Xi, TAO Guangshi, Obstetrics and Gynecology Department, the Second Xiangya Hospital of Central South University ...... page:2009-2012 New progress of non-motor symptoms in Parkinson's disease (帕金森病患者非运动症状的研究进展) CHEN Suyi, ZHANG Xianping, Department of Neurology, Anhui Wuhu Conch Hospital ...... page:2013-2017 Research progression in deubiquitination enzymes in the ubiquitination of hypoxia-inducible factor-1α (去泛素化酶影响低氧诱导因子-1α泛素化过程的研究进展) SUN Wei, SHI Yonghong, Inner Mongolia Medical University, Department of Pathology, Affiliated Hospital in Inner Mongolia Medical University ...... page:2018-2022 Clinicopathological analyses of gastric neuroendocrine tumor misdiagnosis as gastric adenocarcinoma (胃神经内分泌肿瘤误诊为胃腺癌临床病理分析) CUI Miao, WEI Jianguo, XU Chunwei, WU Yongfang, WANG Huaitao, WANG Haiyan, ZHANG Bo, SHAO Yun, TAI Yanhong, LI Xiaobing, Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Department of Pathology, Shaoxing People′s Hospital ...... page:2023-2026 CAOD TOC Alerts Note Thank you for choosing CAOD Table of Contents (TOC) Alert Service. 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Fwd: Military Medical Journal of South China, Year 2015, Issue 11 -New Issue Alert.

From: order@email.oriprobe.com

Date: January 17, 2016 at 08:05AM

New Issue TOC Alert Dear Valued Customer, We are pleased to deliver your requested table of contents alert for Military Medical Journal of South China. Year 2015 Issue 11 is now available on CAOD. In this issue: hua nan guo fang yi xue za zhi gao yue (《华南国防医学杂志》稿约) BEN Kanbianjibu ...... page:802 Effect of Yisuishengxue Granule Medicated Serum on Erythroid Differentiation (益髓生血颗粒含药血清对K562细胞向红系分化的影响) CHENG Yan-ling, MA Yan-ni, ZHOU Ya-li, SUN Yu-wen, FANG Su-ping, LIU Li, CHU Na-li, ZHANG Xin-hua, WU Zhi-kui, The Affiliated Guang'anmen Hospital, China Academy of Chinese Medicine Sciences ...... page:807-809+813 A Multivariable Dynamics Analysis on the Mechanism of Functional Delayed Gastric Emptying with Cybernetics (基于控制论对功能性胃排空障碍机制的多变量动力学研究) CAI Xun, MA Dan-dan, YE Jia-xin, HU Yi-lin, JIN Wei-dong, Department of General Surgery, Wuhan General Hospital of Guangzhou Command ...... page:810-813 Effects of Lipoxin A4 on One-lung Ventilation Induced Lung Injury (脂氧素A4对兔单肺通气肺损伤的保护作用及机制) YOU Zhi-jian, LI Ji-yuan, XU Hong-xia, SU Bai-qin, Department of Anesthesiology, Second Affiliated Hospital of Medical College of Shantou University ...... page:814-816+823 Clinical Observation of Bronchial Blocker for One Lung Ventlation during Right-sided Video-assisted Thoracic Surgery (支气管封堵器用于右侧胸腔镜手术单肺通气的临床研究) HU Bo, LI Zhao-ju, SHAO Wei-dong, ZHOU Qiao-mei, YANG Rui-yu, TU Wei-feng, Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Command ...... page:817-820 Yisui Shengxue Granule Combined with Hydroxycarbamide in Treating Patients with Thalassemia Intermedia (益髓生血颗粒联合羟基脲治疗中间型β地中海贫血) ZHOU Ya-li, LI Yao-yun, KONG Xiang-jing, CHENG Yong-sheng, ZHOU Tian-hong, YIN Xiao-lin, ZHANG Xin-hua, Department of Hematology, No.303 Hospital of the People's Liberation Army ...... page:821-823 Application of Multidisciplinary Team Care Management in Hospital Patients with Hypoglycemia Risk Control (多学科护理合作在住院患者低血糖风险控制中的应用) SUN Hui-ling, ZHANG Yu, XIANG Guang-da, YUE Ling, XIANG Lin, Department of Endocrinology, Wuhan General Hospital of Guangzhou Command ...... page:824-826 Significance of Eosinophils and Platelets in Peripheral Blood in Patients with Acute Myocardial Infarction (急性心肌梗死患者外周血中嗜酸性粒细胞和血小板数量变化的意义) WANG De-zhao, WEI Xin, SONG Bei, ZHANG Chu-ji, LI Qun, FU Qiang, CHEN Wei, CHEN Bu-xing, Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University ...... page:827-829+842 Diagnostic Value of Dynamic Radiographs in Patients with Instability and Atypical Spondylolisthesis Lumbar (动力位X线片对腰椎不稳定及不典型滑脱的诊断价值) HE You-cai, WU Chao, YAO Ben-bo, ZHAN Kong-cai, ZHOU Tao, Department of Radiology, Fourth People 's Hospital of Zigong City ...... page:830-832+846 Glutahione S-transferase A1 Polymorphism and the Susceptibility of Preeclampsia (谷胱甘肽S转移酶A1基因多态性与子癇前期发病的相关性) DING Jian, TIAN Li-bin, Department of Gynaecology and Obstetrics, Wuxi Women and Children Healthcare Hospital ...... page:833-835 Effect of Nucleotide Analogues in Preventing Anti-tuberculosis Agents Induced Liver Injury in Tuberculosis Patients with HBV Co-infection (核苷(酸)类似物预防乙肝病毒携带者抗结核药致肝损害的评价) XIAO Qing-hua, LIU Jian-xiang, ZHANG Ji-hong, Department of Infectious Diseases, No. 163 Hospital of the People's Liberation Army ...... page:836-838 Impact Factors of Cardiopulmonary Resuscitation Success in Cardiopulmonary Arrest Patients (心跳呼吸骤停患者心肺复苏成功的影响因素) ZHOU Wei-liang, ZENG Fan-jie, QIN Wei-yi, TANG Shao-hui, PENG Xiong, Emergency Department, Guangzhou General Hospital of Guangzhou Command ...... page:839-842 Changes of Color Doppler Sonographic Features of Nasopharyngeal Carcinoma Neck Metastasis Lymph Nodes before and after Radiotherapy (鼻咽癌颈部转移淋巴结放疗前后彩色多普勒超声特征变化规律) YANG Lin, LIN Li, LIANG Yan, Department of Ultrasonic, Wuhan General Hospital of Guangzhou Command ...... page:843-846 Influencial Factors on Life Quality of Military Retired Cadres in Hubei (湖北地区军队离休干部生活质量影响因素) ZHU Song, LIU Jun, CHEN Wen-min, HUANG Yong-bing, LI Bin, Depertment of Medical Affair, Wuhan General Hospital of Guangzhou Command ...... page:847-852+857 zhu zhu hai mou bu shi bing zuo chong bing dong fang ti xue qing liu xing bing xue diao cha ji fang zhi zhi shi zhi xiao lv fen xi (驻珠海某部士兵恙虫病东方体血清流行病学调查及防治知识知晓率分析) SU Jianxin, LIU Zuohuan, CHEN Ronghua, HONG Wenyan, YU Dexian, LIU Jianwei, TANG Boheng ...... page:853-854 nan hai mou dao jun min chang jian bing de ji bing pu bi jiao (南海某岛军民常见病的疾病谱比较) WU Zuohua, LIN Zhongjie, LIU Huanbo ...... page:855-857 zhong yao min gan di qu jun shi xing dong de wei qin bao zhang (重要敏感地区军事行动的卫勤保障) YANG Jun, NIE Chenyang, WAN Haijun, ZHAO Jinliang, HU Xiaomei, GONG Liang, CAO Honghai, CHEN Zuo ...... page:858-859+871 ye zhan jiu yuan jian yan zhuang bei zheng he ce lue de xin si kao (野战救援检验装备整合策略的新思考) SUN Changjian ...... page:860-861 Preparation of Amlodipine Besylate Tablets by Direct Powder Compression (粉末直接压片制备苯磺酸氨氯地平片) LIU Zu-xiong, YANG Yan-dong, LIU Hui, TAO Zhi-qiang, LI Yin-ke, YANG Xiao-song, Departmrnt of Pharmacy, Wuhan General Hospital of Guangzhou Command ...... page:862-865 Requirements for Outpatient Department Informization in the New Round of Military Hospital Accreditation (新一轮军队医院等级评审对门诊信息化建设的要求) TANG Yun-zhang, JIANG Ping, JIN Xiao-zhi, LI Jin-e, Outpatient Department, Wuhan General Hospital of Guangzhou Military Command ...... page:866-868 ji yu gang wei guan li de men zhen hu shi pei xun shi jian tan tao (基于岗位管理的门诊护士培训实践探讨) JIANG Ping, LU Huifang, LI Jine, YANG Si, TANG Yunzhang ...... page:869-871 gao qiang du jun shi xun lian dui shen zang gong neng de ying xiang (高强度军事训练对肾脏功能的影响) LIU Zhiang, ZUO Xiaohong, HUANG Qiang, FANG Rumei ...... page:872-873 xue ye tou xi zi ti dong jing mai nei zuo ct xue guan zao ying de ying yong (血液透析自体动静脉内瘘CT血管造影的应用) FANG Liming, ZHANG Xiaosheng, HU Yong, GAI Fengfeng ...... page:874-875 jing qi dan kong fu qiang jing dan nang qie chu shu lin chuang ying yong jia zhi (经脐单孔腹腔镜胆囊切除术临床应用价值) WANG Liang, HE Yonggang, LI Jing, ZHENG Zuo ...... page:876-878 qi shi (启事) BEN Kanbianjibu ...... page:878 po gong chan chan hou chu xue xiang guan wei xian yin su dui zhao yan jiu (剖宫产产后出血相关危险因素对照研究) YU Xuemei ...... page:879-880 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