NonScarring Diffuse Hair Loss in Women: a Clinico‐Etiological Study from tertiary care center in North‐West India

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2IPhltR

Violaceous papules on the hands

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2wR9MOv

A simple and cost‐efficient adherent culture platform for human gastric primary cells, as an in vitro model for Helicobacter pylori infection

Helicobacter, EarlyView.


https://ift.tt/2L5DXot

Kardioanästhesie: Monitoring und aktuelle hämodynamische Konzepte

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 332-345
DOI: 10.1055/s-0043-106281

Die Krankheitsschwere herzchirurgischer Patienten und die Komplexität der Eingriffe haben in den letzten Jahren deutlich zugenommen. Dies stellt nicht nur erhöhte Anforderungen an die neurologische und hämodynamische Überwachung, sondern macht es auch erforderlich, die hämodynamische Therapie – unter Berücksichtigung aktueller pharmakologischer Entwicklungen – individuell dem höheren Risikoprofil der Patienten anzupassen.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2rOL4JF

Kasuistik: Metamizol-induzierte Agranulozytose

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 388-394
DOI: 10.1055/s-0043-115329

Metamizol hat insgesamt ein günstiges Nebenwirkungsprofil – aber es birgt ein höheres Risiko einer medikamenteninduzierten Agranulozytose als andere Schmerzmittel und darf daher nicht unkritisch eingesetzt werden. Dieser Beitrag berichtet von einem Patienten, der nach prothetischem Hüftersatz eine medikamenteninduzierte Agranulozytose – mutmaßlich durch Metamizol – entwickelt und trotz maximaler Therapie im septischen Schock verstirbt.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2INqhjI

Intensivmedizin: Ist ein hohes CRP ein geeigneter Prädiktor für ein postoperatives Delir?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 324-327
DOI: 10.1055/a-0607-6157

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2Gr1M6p

Kardioanästhesie: Monitoring der Gerinnung und Gerinnungstherapie

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 364-379
DOI: 10.1055/s-0043-112099

Die Transfusion von allogenen Blutprodukten ist mit einer Erhöhung der perioperativen Morbidität und Letalität assoziiert. Störungen der Hämostase sind insbesondere bei kardiochirurgischen Patienten häufig anzutreffen und können zu transfusionspflichtigen Blutungen führen. Eine zielgerichtete Therapie der häufig komplexen Gerinnungsstörungen erfordert eine differenzierte Diagnostik.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2INq00a

Kolloide zur Volumentherapie nach Verbrennung geeignet?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 324-324
DOI: 10.1055/a-0607-6170

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2INq1Bg

Kardioanästhesie 2018 – Wandel als Chance?

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 329-330
DOI: 10.1055/a-0588-4274

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2ItTY5X

Hypertone Lösungen bei hämorrhagischem Schock ohne gesicherten Vorteil

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 327-328
DOI: 10.1055/a-0607-6183

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2Gr1HQ9

Pssst … AINS-Secrets: heute aus der Urologie – TUR-Syndrom

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 395-398
DOI: 10.1055/s-0042-101662

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2IrF0gC

Erratum: Atemwegsmanagement – der schwierige Atemweg beim thoraxchirurgischen Patienten

Anästhesiol Intensivmed Notfallmed Schmerzther
DOI: 10.1055/a-0613-2898

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2rOL1gX

Sauerstoffgabe für die Mutter bei Kaiserschnitt und oxidativer Stress des Kindes

Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 322-322
DOI: 10.1055/a-0607-6131

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

https://ift.tt/2INq2Fk

Interchangeability of counts of cases and hours of cases for quantifying a hospital's change in workload among four-week periods of 1 year

Recent studies have made longitudinal assessments of case counts using State (e.g., United States) and Provincial (e.g., Canada) databases. Such databases rarely include either operating room (OR) or anesthesia times and, even when duration data are available, there are major statistical limitations to their use. We evaluated how to forecast short-term changes in OR caseload and workload (hours) and how to decide whether changes are outliers (e.g., significant, abrupt decline in anesthetics).

https://ift.tt/2ItNynd

Supraglottoplasty in children with laryngomalacia: A review and parents' appraisal

To assess the parents' perspective concerning the children's clinical picture before and after supraglottoplasty for the treatment of laryngomalacia (LM).

https://ift.tt/2rWZDuj

Sentinel lymph node biopsy in cutaneous melanoma of the head and neck using the indocyanine green SPY Elite system

Lymph node status is the single most important prognostic factor for patients with early-stage cutaneous melanoma. Sentinel lymph node biopsy (SLNB) has become the standard of care for intermediate depth melanomas. Modern SLNB implementation includes technetium-99 lymphoscintigraphy combined with local administration of a vital blue dye. However, sentinel lymph nodes may fail to localize in some cases and false-negative rates range from 0 to 34%. Here we demonstrate the feasibility of a new sentinel lymph node biopsy technique using indocyanine green (ICG) and the SPY Elite near-infrared imaging system.

https://ift.tt/2k8KEd4

How to Treat Fatty Liver Disease in Kids

Fatty liver disease is a greater health concern for children who are overweight or obese. As a parent of a child who struggles with excessive weight gain, it is important to understand the risk factors associated with fatty liver disease and ways to mitigate them. Here is our best advice for how to create a healthy lifestyle for your family.

The post How to Treat Fatty Liver Disease in Kids appeared first on ChildrensMD.

https://ift.tt/2k5rrsL

Minimally-invasive biomarker studies in eosinophilic esophagitis: a systematic review

Publication date: Available online 10 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Brittany T. Hines, Matthew A. Rank, Benjamin L. Wright, Lisa A. Marks, John B. Hagan, Alex Straumann, Matthew Greenhawt, Evan S. Dellon
BackgroundEosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus which currently requires repeated endoscopic biopsies for diagnosis and monitoring as no reliable non-invasive markers have been identified.ObjectiveTo identify promising minimally-invasive EoE biomarkers and remaining gaps in biomarker validation.MethodsWe performed a systematic review of EMBASE, Ovid Medline, PubMed, and Web of Science from inception to June 6, 2017. Studies were included if subjects met the 2007 consensus criteria for EoE diagnosis, a minimally-invasive biomarker was assessed, and the study included at least 1 control for comparison.ResultsThe search identified 2094 studies, with 234 reviewed at full text level, and 49 included in the analysis (20 adult, 19 pediatric, 7 pediatric and adult, and 3 not stated). The majority (26 of 49) were published after 2014. Thirty-five studies included normal controls, 9 analyzed atopic controls, and 29 compared samples from subjects with active and inactive EoE. Minimally-invasive biomarkers were obtained from peripheral blood (n=41 studies), sponge/string samples (3), oral/throat swab secretions (2), breath condensate (2), stool (2), and urine (2). The most commonly reported biomarkers were peripheral blood eosinophils (16), blood and string eosinophil granule proteins (14), and eosinophil surface or intracellular markers (12). EoE biomarkers distinguished active EoE from normal controls in 23 studies, atopic controls in 2 studies, and inactive EoE controls in 20 studies.ConclusionSeveral promising minimally-invasive biomarkers for EoE have emerged; however, few are able to differentiate EoE from other atopic diseases.



https://ift.tt/2rQRfwi

Medical and dietary management of eosinophilic esophagitis

Publication date: Available online 10 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Quan M. Nhu, Seema S. Aceves
ObjectiveEosinophilic esophagitis (EoE) is a disease of chronic, allergen-driven, T-helper 2 (Th2) immune-mediated inflammation that progresses to fibrostenosis of the esophagus if left untreated. There are currently no FDA-approved drugs for the treatment of EoE. This review focuses on medical and dietary management of EoE.Data SourcesManuscripts on EoE treatments are identified on PubMed.Study SelectionsOriginal research, randomized control trials, retrospective studies, meta-analyses, case series, and on occasions, case reports of high relevance, are selected and reviewed.ResultsCurrent treatment strategies available to EoE patients center on monotherapy or combination therapy with dietary modification to exclude antigenic stimulation and topical corticosteroids to control Th2-mediated tissue inflammation and pathologic remodeling. Dilation as a rescue therapy for the narrowed, fibrostenotic, symptomatic esophagus can potentially be avoided with optimal medical and elimination diet therapies. The molecular mechanisms underlying EoE pathogenesis are being unraveled, from which targeted therapies can be developed and evaluated in pre-clinical and clinical studies. Current clinical research efforts focus on optimization of topical corticosteroid delivery, dosing, frequency, and duration of treatment, either alone or in combination with tailored elimination diet. Preliminary clinical trials with biologics targeting IL-5 and IL-13/IL-4 have been completed.ConclusionsTopical corticosteroid, elimination diet, and dilation are the current treatment modalities for confirmed EoE. The use of proton-pump inhibitors (PPI) is being suggested as a potential regimen to treat EoE, based on evolving understanding of PPI-responsive esophageal eosinophilia (PPI-REE). The complexity of EoE treatment regimens and frequent follow ups require a multimodal, multi-disciplinary management approach to optimize patient care.



https://ift.tt/2k7PPKq

Efficacy of a single dose of omalizumab for the prevention of ethylene oxide intraoperative anaphylaxis

Publication date: Available online 16 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Maria Beatrice Bilò, Alice Corsi, M. Feliciana Brianzoni, M. Stella Garritani, Leonardo Antonicelli




https://ift.tt/2KuDyuo

Successful treatment switch from lenvatinib to sorafenib in a patient with radioactive iodine-refractory differentiated thyroid cancer intolerant to lenvatinib due to severe proteinuria

Sorafenib and lenvatinib showed efficacy for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) in pivotal phase 3 clinical trials. Although the efficacy of lenvatinib in patients who received previous treatment with multi-target kinase inhibitors (m-TKIs), including sorafenib, was reported, the efficacy of sorafenib in patients who previously received lenvatinib remains unknown. A 75-year-old woman diagnosed as RAI-refractory poorly differentiated carcinoma with multiple lung metastases and started treatment with lenvatinib.

https://ift.tt/2IpTAt5

Aging in the United States

The number of Americans over the age of 65 has been growing much faster than the overall population's growth rate. These changes can be largely attributed to the improvement in life expectancy. This demographic shift yields a unique and exciting opportunity to provide both expedient and cost-efficient care to a growing patient population.

https://ift.tt/2rWQMc3

Dysphagia in the Older Patient

Dysphagia in older adults is a challenging problem and necessitates a team approach. The key to effective management is recognition. Patients tend to dismiss their symptoms as normal aging; therefore, early diagnosis depends on the diligence of the primary care doctors. No diagnostic technique can replace the benefits of a thorough history, with a detailed understanding of nutritional status and aspiration risk. Although one of the main goals in management is to ensure safe swallowing, the impact of a nonoral diet on the quality of life of patients should not be underestimated.

https://ift.tt/2IqnLR5

Sleep Apnea and Sleep-Disordered Breathing

Older adults undergo gradual changes in their sleep patterns. It is important to differentiate normal age-related sleep changes from sleep disorders. Because sleep disorders can impact an older adult's day-to-day life and contribute to various comorbidities, these patients should be carefully screened by using a detailed medical history, combined with a detailed sleep history. There is a high prevalence of undiagnosed and untreated sleep apnea in the elderly. Early identification and appropriate management of this disorder may not only provide improvement in quality of life but also decrease disease-associated morbidity and mortality.

https://ift.tt/2rR4CMN

The Emerging Field of Geriatric Otolaryngology

Sub-specialization within otolaryngology, like other specialties, is driven by accumulation of new knowledge and technology. For a variety of reasons, the establishment of a new subspecialty of geriatric otolaryngology is unlikely. Education of all otolaryngologists in the basic principles of gerontology and geriatric otolaryngology is achievable and represents a preferred strategy.

https://ift.tt/2IpFuI9

Facial Plastic Surgery in the Geriatric Population

Greater life expectancy with advancements in technology and medicine has led to an increasing interest in facial rejuvenation. Facial aging is an inevitable process that largely results from soft tissue descent and volumetric deflation. However, a comprehensive knowledge of the aging process and precise assessment of the exact pathologies yielding the patient's senescent appearance is essential to produce the best cosmetic outcome. The surgeon must evaluate each region independently and the aging face as a whole to ensure a pleasing, natural appearance.

https://ift.tt/2GrQ23J

Treating the Elderly with Science and Dignity

Just as children are not simply small adults, elderly individuals have medical needs that may not be satisfied by just translating medical knowledge from younger adults. Geriatric medicine deals exclusively with the health and diseases of the elderly, including many issues that affect them primarily due to the aging of organs over time, such as cataracts, dementia, and presbycusis, among others. A challenge in this population is that care of one problem must include consideration of a multitude of parameters, including coexistent illnesses and polypharmacy, for better decision making.

https://ift.tt/2IpFfwJ

Targeted delivery of CD44s-siRNA by ScFv overcomes de novo resistance to cetuximab in triple negative breast cancer

Publication date: July 2018
Source:Molecular Immunology, Volume 99
Author(s): Wenyan Fu, Hefen Sun, Yang Zhao, Mengting Chen, Lipeng Yang, Xueli Yang, Wei Jin
The overexpression of EGFR often occurs in TNBC, and the anti-EGFR receptor antibody cetuximab is used widely to treat metastatic cancer in the clinic. However, EGFR-targeted therapies have been developed for TNBC without clinical success. In this study, we show that impaired EGFR degradation is crucial for resistance to cetuximab, which depends on the cell surface molecule CD44. To further investigate the role of CD44 in EGFR signaling and its treatment potential, we developed a targeting fusion protein composed of an anti-EGFR scFv generated from cetuximab and truncated protamine, called Ce-tP. CD44 siRNA can be specifically delivered into EGFR-positive TNBC cells by Ce-tP. Efficient knockdown of CD44 and suppression of both EGFR and downstream signaling by the Ce-tP/siRNA complex were observed in EGFR-positive TNBC cells. More importantly, our results also showed that targeted delivery of siRNA specific for CD44 can efficiently overcome resistance to EGFR targeting in TNBC cells both in vitro and in vivo. Overall, our results establish a new principle to achieve EGFR inhibition in TNBC and limit drug resistance.



https://ift.tt/2IrC03T

Web-based information on oral dysplasia and precancer of the mouth – Quality and readability

Publication date: July 2018
Source:Oral Oncology, Volume 82
Author(s): Abdullah Alsoghier, Richeal Ni Riordain, Stefano Fedele, Stephen Porter
ObjectivesThe numbers of individuals with oral cancer are increasing. This cancer is preceded by oral epithelial dysplasia (OED). There remains no detailed study of the online information presently available for patients with OED or indeed what information such patients may require to be appropriately informed regarding their condition. Hence, the aim of the present study is to assess the patient-oriented web content with respect to OED.MethodsThe first 100 websites yielded from nine searches performed using different search terms and engines were considered. These were assessed for content, quality (DISCERN instrument, Journal of the American Medical Association benchmarks, and Health on Net seal) and readability (Flesch Reading Ease Score and Flesch-Kincaid Grade Level).ResultsThere was a general scarcity of OED content across the identified websites. Information about authors, sources used to compile the publication, treatment, and shared decision were limited or absent. Only 6% and 27% of the websites achieved all the four JAMA benchmarks and HON seal, respectively. The average readability level was at 10th grade (US schools), which far exceeds the recommended levels of written health information.ConclusionAt present patients seeking information on OED are likely to have difficulty in finding reliable information from the Web about this disorder and its possible impact upon their life. Further work is thus required to develop a web-based resource regarding OED that addresses the shortfalls demonstrated by the current study.



https://ift.tt/2IOOjdW

Valproate-induced hyperammonemia - uncovering an underlying inherited metabolic disorder: a case report

Sodium valproate is a commonly used anticonvulsant. It is widely recognized that valproate can cause hyperammonemia, particularly in people with underlying liver disease. Patients with urea cycle disorders are...

https://ift.tt/2rQFciA

The Voice and the Larynx in Older Adults—What’s Normal, and Who Decides?

Voice problems in older adults are common, with estimated prevalences of up to 30% across various samples and query methodologies. Age-related changes of laryngeal anatomy and physiology are thought to lead to both presbylaryngis and dysphonia, but many patients with findings of presbylaryngis are asymptomatic, and the incidence of presbylaryngis remains incompletely understood. A challenge in management of voice disorders in older adults is thus what to consider normal vs pathologic, particularly in the context of presbylaryngis.

https://ift.tt/2IM8U2C

Clinical and Social Factors That Distinguish Presbylaryngis From Pathologic Presbyphonia

This cohort study determines what distinguishes pathologic presbyphonia from presbylaryngis in any adults older than 74 years.

https://ift.tt/2IwBWzJ

Patient-Specific, 3-Dimensionally Printed Endoscopic Sinus and Skull Base Surgical Model

This study describes the development and assessment of 3-dimensionally printed sinus and skull base models for use in endoscopic skull base surgery.

https://ift.tt/2rONZlE

The Role of Otolaryngologists in Eradicating Human Papillomavirus

This Viewpoint discusses the low rates of vaccination for human papillomavirus in the United States and the role that otolaryngologists can play in improving public health policy about this vaccination.

https://ift.tt/2Ira7J3

Postoperative Facial Baroparesis While Flying

This case report describes a unique iatrogenic mechanism of baroparesis in a patient who underwent surgical treatment of a facial nerve schwannoma.

https://ift.tt/2GkiQjm

A Novel Approach to the National Resident Matching Program

This Viewpoint details a star system for matching otolaryngology–head and neck surgery applicants with programs.

https://ift.tt/2uvZjam

May 2018 Issue Highlights

https://ift.tt/2wPCQWM

Risk Factors for Complication After Pediatric Tonsillectomy

This cohort study examines the association between posttonsillectomy complication rate and the age and weight of the child at the time of surgery.

https://ift.tt/2IsCOpz

Multidisciplinary Clinical Treatment of Head and Neck Cancer—Reply

In Reply We thank Mark and colleagues for recognizing our publication and for their shared dedication to improving cancer care. We find their results in the field of prostate cancer to be quite interesting, particularly their findings regarding a survival benefit in patients with access to a multidisciplinary clinic (MDC) treatment model. Likewise, we plan to investigate potential survival benefits in our own head and neck cancer MDC treatment model once we have accrued sufficient patient volumes and follow-up time. Recent retrospective studies in head and neck cancer have identified survival benefits in patients with access to multidisciplinary evaluations in particular subsites. It will be valuable to see if we also find this site-specific advantage in our own MDC population. Again, we thank the writers for their supportive response and for their efforts to optimize complex cancer care.

https://ift.tt/2IvtrWk

Analysis of Vocal Fold Motion Impairment in Neonates Undergoing Congenital Heart Surgery

This cross-sectional analysis evaluates the cost, postprocedure length of stay, and outcomes for neonates with vocal fold motion impairment after congenital heart surgery.

https://ift.tt/2IuiNyK

Hypercoagulability, Obstructive Sleep Apnea, and Pulmonary Embolism—Reply

In Reply We thank Dr Alonso-Fernández and colleagues for their interest in our recently published study titled, "Association Between Hypercoagulability and Severe Obstructive Sleep Apnea." The comments raised by the readers can be summarized in that a significant association exists between obstructive sleep apnea (OSA) and pulmonary embolism (PE), which can be another consequence of hypercoagulability in severe OSA.

https://ift.tt/2pvXqVp

Survival in Surgically Treated Pediatric Head and Neck Sarcomas

This study investigates the role of facility and system factors associated with survival in pediatric patients with head and neck sarcomas.

https://ift.tt/2HwRfsG

Self-reported Hearing Difficulty and Risk of Accidental Injury in Adults

This cross-sectional analysis examines 2007 to 2015 data from the National Health Interview Survey to assess the association of hearing difficulty with risk of accidental injury in US adults.

https://ift.tt/2G5lN2Y

Preoperative Facial Nerve Mapping and Pediatric Facial Vascular Anomaly Resection

This historically controlled study investigates if preoperative facial nerve mapping is associated with intraoperative facial nerve injury risk and safe surgical approach options compared with standard nerve integrity monitoring.

https://ift.tt/2uxnrcA

Errors in Items and Algorithm in Questionnaire for Validation Study

To the Editor We write to report a scoring algorithm error that was included in our article, "Development and Initial Validation of a Consumer Questionnaire to Predict the Presence of Ear Disease," published online on August 3, 2017, and in the October 2017 issue of JAMA Otolaryngology–Head & Neck Surgery. In this study, we examined the validity of the Consumer Ear Disease Risk Assessment (CEDRA), a questionnaire for the self-assessment of risk of ear diseases associated with hearing loss. The error was discovered by a member of our research team who was preparing a digital version of the questionnaire used in our study. The error occurred in the analysis code for 3 of the 28 questionnaire items included in the scoring (questions 16, 18, and 19). For these 3 questions, the 4-item rating scales were dichotomized incorrectly. After correcting the algorithm for these questions, we found slightly different results, without any differences in statistical significance of these results. The overall results and conclusions remain unchanged.

https://ift.tt/2FzlwIO

Thyroidectomy Practice After Implementation of 2015 American Thyroid Association Guidelines for Thyroid Carcinoma

This cohort study assesses surgical practice changes regarding lobectomy, up-front thyroidectomy, and completion thyroidectomy in a tertiary medical center before and after the implementation of the 2015 American Thyroid Association guidelines for well-differentiated thyroid carcinoma.

https://ift.tt/2GkiERa

Tubular Neck Mass

A man in his 60s had right-sided lateral neck pain; palpation demonstrated a mass running along the lateral border of the sternocleidomastoid (SCM) muscle and imaging showed an elongated enhancing tubular structure along the lateral surface of the right SCM muscle. What is your diagnosis?

https://ift.tt/2GiNR7x

Life Experience of Patients With Unilateral Vocal Fold Paralysis

This mixed methods study (surveys and interviews) promotes patient-centered care by characterizing the patient experiences of living with unilateral vocal fold paralysis.

https://ift.tt/2uLjrW1

Injested Fidget Spinner

This is the report of a case of a young woman with a complex mental health history including depression and eating disorder who presented with severe neck pain and vomiting after reporting ingestion of a fidget spinner toy broken into 3 pieces.

https://ift.tt/2FlLJrG

Single-Stage Mastoid Obliteration in Cholesteatoma Surgery

This systematic study analyzes the literature on recurrent and residual cholesteatoma rates after single-stage canal wall up and canal wall down tympanoplasty with mastoid obliteration.

https://ift.tt/2pgosjo

Hypercoagulability, Obstructive Sleep Apnea, and Pulmonary Embolism

To the Editor We read with great interest the article written by Hong et al. They found that prothrombin time in patients with obstructive sleep apnea (OSA) was shorter compared with controls, concluding that OSA might lead to a prothrombotic state, a probable contributing factor to the increase in cardiovascular complications in OSA, including ischemic heart disease and stroke. Observational studies suggest that suppression of apneas by continuous positive airway pressure (CPAP) may improve cardiovascular outcomes. Nevertheless, recent data from a large randomized clinical trial did not prevent cardiovascular events in patients with moderate-to-severe OSA, despite significant reduction in daytime sleepiness. One possible explanation is that they included patients with previous cardiovascular disease with an established atherosclerosis burden in arterial vessels and heart remodeling, which could be, by this time, unalterable by the CPAP effect.

https://ift.tt/2IGIHzs

An Aggressive Sinonasal Mass With Parameningeal Extension

A woman in her 60s presented with sinus pressure progressing to dental pain; imaging revealed a mass arising from the skull base and nasopharynx and involvement of the right posterior orbit. What is your diagnosis?

https://ift.tt/2Iu0nhG

Multidisciplinary Clinical Treatment of Head and Neck Cancer

To the Editor We commend the authors on their adoption of a multidisciplinary clinic (MDC) for the treatment of head and neck cancers and we agree with their conclusion that the cooperative treatment of cancer patients by relevant specialties is superior to a multiappointment approach. In their study, Townsend et al were able to show a significant decrease in treatment delays for patients from both the time of referral and following their first appointment with the team. We have had the same experience in our own MDC.

https://ift.tt/2pgcyGg

A Rare Cause of Oropharyngeal and Supraglottic Airway Narrowing

A man presented with right lower quadrant abdominal pain; imaging of the neck revealed a submucosal soft-tissue mass containing few punctate calcifications centered in the epiglottis narrowing of the oropharyngeal and supraglottic laryngeal airways by the enlarged epiglottis. What is your diagnosis?

https://ift.tt/2IJ7Yct

Effect of paracetamol/prednisolone versus paracetamol/ibuprofen on post-operative recovery after adult tonsillectomy

To compare the effect of Paracetamol/Prednisolone versus Paracetamol/Ibuprofen on post-operative recovery after adult tonsillectomy.

https://ift.tt/2IpZfzs

A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma

The main cause of primary hyperparathyroidism is a single parathyroid adenoma. Parathyroid lipoadenomas contain abundance of fat cells. Because of these histological features, they can mimic normal parathyroid tissue at the histopathologic examination and radiological imaging could be difficult to localize lipoadenomas.

https://ift.tt/2wNCpwj

From the pages of allergywatch July 2018

In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), type 2 inflammation and tissue eosinophilia suggest a poor prognosis, including increased postoperative recurrence risk. Recent studies have found that proton pump inhibitors (PPIs) can suppress production of the eosinophil chemoattractant eotaxin-3. The authors assessed the role of Th2 mediators in CRSwNP, along with the effects of eotaxtin 3 inhibition using PPIs.

https://ift.tt/2IvrQPE

Omalizumab can inhibit respiratory reaction during aspirin desensitization

Aspirin desensitization has been associated with benefit in management of aspirin exacerbated respiratory disease (AERD). An intervention that would encourage aspirin desensitization to be performed more frequently has substantial potential for improving outcomes and quality of life in patients with AERD.

https://ift.tt/2IJvx7M

Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

Van Houcke, J; Bollaerts, I; Geeraerts, E; Davis, B; Beckers, A; Van Hove, I; Lemmens, K; ... Moons, L; + view all Van Houcke, J; Bollaerts, I; Geeraerts, E; Davis, B; Beckers, A; Van Hove, I; Lemmens, K; De Groef, L; Moons, L; - view fewer (2017) Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes. Neurobiology of Aging , 60 pp. 1-10. 10.1016/j.neurobiolaging.2017.08.013 .

https://ift.tt/2wM570t

Affective spectrum symptoms and self-criticism: A behavioral genetic approach

Bleys, D; Luyten, P; Claes, S; Soenens, B; (2018) Affective spectrum symptoms and self-criticism: A behavioral genetic approach. Journal of Psychosomatic Research , 109 pp. 71-78. 10.1016/j.jpsychores.2018.03.172 . (In press).

https://ift.tt/2IMQiQ1

Quantum plasmonic nanoantennas

Fitzgerald, JM; Azadi, S; Giannini, V; (2017) Quantum plasmonic nanoantennas. Physical Review B , 95 , Article 235414. 10.1103/PhysRevB.95.235414 . Green open access

https://ift.tt/2GraEZP

Nature of the metallization transition in solid hydrogen

Azadi, S; Drummond, ND; Foulkes, WMC; (2017) Nature of the metallization transition in solid hydrogen. Physical Review B , 95 , Article 035142. 10.1103/PhysRevB.95.035142 . Green open access

https://ift.tt/2IpfVan

A systems framework for national assessment of climate risks to infrastructure

Dawson, RJ; Thompson, D; Johns, D; Wood, R; Darch, G; Chapman, L; Hughes, PN; ... Hall, JW; + view all Dawson, RJ; Thompson, D; Johns, D; Wood, R; Darch, G; Chapman, L; Hughes, PN; Watson, GVR; Paulson, K; Bell, S; Gosling, SN; Powrie, W; Hall, JW; - view fewer (2018) A systems framework for national assessment of climate risks to infrastructure. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences , 376 (2121) , Article 20170298. 10.1098/rsta.2017.0298 . Green open access

https://ift.tt/2wNsXsP

Low-pressure phase diagram of crystalline benzene from quantum Monte Carlo

Azadi, S; Cohen, RE; (2016) Low-pressure phase diagram of crystalline benzene from quantum Monte Carlo. Journal of Chemical Physics , 145 , Article 064501. 10.1063/1.4960434 . Green open access

https://ift.tt/2IskdgQ

High-pressure hydrogen sulfide by diffusion quantum Monte Carlo

Azadi, S; Kuhne, TD; (2017) High-pressure hydrogen sulfide by diffusion quantum Monte Carlo. Journal of Chemical Physics , 146 , Article 084503. 10.1063/1.4976836 . Green open access

https://ift.tt/2INuAez

Seasonal immunoregulation in a naturally-occurring vertebrate

Brown, M; Hablützel, P; Friberg, IM; Thomason, AG; Stewart, A; Pachebat, JA; Jackson, JA; (2016) Seasonal immunoregulation in a naturally-occurring vertebrate. BMC Genomics , 17 , Article 369. 10.1186/s12864-016-2701-7 . Green open access

https://ift.tt/2Gs9JZh

Advances in the understanding of hereditary ataxia - implications for future patients

Zeitlberger, A; Ging, H; Nethisinghe, S; Giunti, P; (2018) Advances in the understanding of hereditary ataxia - implications for future patients. Expert Opinion on Orphan Drugs , 6 (3) pp. 203-217. 10.1080/21678707.2018.1444477 .

https://ift.tt/2INukfB

Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2,000 ms

Holmes, E; Kitterick, PT; Summerfield, AQ; (2018) Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2,000 ms. Attention, Perception, & Psychophysics 10.3758/s13414-018-1531-x . (In press).

https://ift.tt/2Gs4dFV

Dose specification for hippocampal sparing whole brain radiotherapy (HS WBRT): considerations from the UK HIPPO trial QA programme

Megias, D; Phillips, M; Clifton-Hadley, L; Harron, E; Eaton, DJ; Sanghera, P; Whitfield, G; (2017) Dose specification for hippocampal sparing whole brain radiotherapy (HS WBRT): considerations from the UK HIPPO trial QA programme. British Journal Of Radiology , 90 (1071) , Article 20160829. 10.1259/bjr.20160829 . Green open access

https://ift.tt/2Ionazk

Randomised controlled trials for multisystemic therapy: when is enough, enough? - Authors' reply

Fonagy, P; START authors, ; (2018) Randomised controlled trials for multisystemic therapy: when is enough, enough? - Authors' reply. Lancet Psychiatry , 5 (5) p. 390. 10.1016/S2215-0366(18)30131-7 .

https://ift.tt/2Gsnas5

The World of UCL

Brewis, G; North, J; Harte, N; (2018) The World of UCL. UCL Press: London, UK. Green open access

https://ift.tt/2IoPrph

Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase

Wise, T; Taylor, MJ; Herane-Vives, A; Gammazza, AM; Cappello, F; Lythgoe, DJ; Williams, SC; ... Arnone, D; + view all Wise, T; Taylor, MJ; Herane-Vives, A; Gammazza, AM; Cappello, F; Lythgoe, DJ; Williams, SC; Young, AH; Cleare, AJ; Arnone, D; - view fewer (2018) Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase. Journal of Affective Disorders , 234 pp. 214-219. 10.1016/j.jad.2018.02.059 . (In press).

https://ift.tt/2wMubnS

Radio weak lensing shear measurement in the visibility domain - II. Source extraction

Rivi, M; Miller, L; (2018) Radio weak lensing shear measurement in the visibility domain - II. Source extraction. Monthly Notices of the Royal Astronomical Society , 476 (2) pp. 2053-2062. 10.1093/mnras/sty371 . Green open access

https://ift.tt/2Ion4Yu

Interlaboratory Comparison of the Pneumococcal Multiplex Opsonophagocytic Assays and Their Level of Agreement for Determination of Antibody Function in Pediatric Sera

Balloch, A; Roalfe, L; Ekstrom, N; Nguyen, CD; Spry, L; Marimla, RA; Licciardi, PV; ... Mulholland, EK; + view all Balloch, A; Roalfe, L; Ekstrom, N; Nguyen, CD; Spry, L; Marimla, RA; Licciardi, PV; Goldblatt, D; Mulholland, EK; - view fewer (2018) Interlaboratory Comparison of the Pneumococcal Multiplex Opsonophagocytic Assays and Their Level of Agreement for Determination of Antibody Function in Pediatric Sera. mSphere , 3 (2) , Article e00070-18. 10.1128/mSphere.00070-18 . Green open access

https://ift.tt/2wMtZoE

A morphometric signature of depressive symptoms in unmedicated patients with mood disorders

Wise, T; Marwood, L; Perkins, AM; Herane-Vives, A; Williams, SCR; Young, AH; Cleare, AJ; Wise, T; Marwood, L; Perkins, AM; Herane-Vives, A; Williams, SCR; Young, AH; Cleare, AJ; Arnone, D; - view fewer (2018) A morphometric signature of depressive symptoms in unmedicated patients with mood disorders. Acta Psychiatrica Scandinavica 10.1111/acps.12887 .

https://ift.tt/2IRyzXT

The Network Structure of Schizotypal Personality Traits

Fonseca-Pedrero, E; Ortuño, J; Debbané, M; Chan, RCK; Cicero, D; Zhang, LC; Brenner, C; ... Fried, EI; + view all Fonseca-Pedrero, E; Ortuño, J; Debbané, M; Chan, RCK; Cicero, D; Zhang, LC; Brenner, C; Barkus, E; Linscott, RJ; Kwapil, T; Barrantes-Vidal, N; Cohen, A; Raine, A; Compton, MT; Tone, EB; Suhr, J; Inchausti, F; Bobes, J; Fumero, A; Giakoumaki, S; Tsaousis, I; Preti, A; Chmielewski, M; Laloyaux, J; Mechri, A; Aymen Lahmar, M; Wuthrich, V; Larøi, F; Badcock, JC; Jablensky, A; Isvoranu, AM; Epskamp, S; Fried, EI; - view fewer (2018) The Network Structure of Schizotypal Personality Traits. Schizophrenia Bulletin , Article sby044. 10.1093/schbul/sby044 .

https://ift.tt/2wPoeXj

Quadrupole and hexadecapole transition dipole moment alignment in fluorescent protein Homo-FRET

Bain, AJ; MASTERS, T; (2018) Quadrupole and hexadecapole transition dipole moment alignment in fluorescent protein Homo-FRET. In: Andrews, David L. and Bain, Angus J. and Nunzi, Jean-Michel and Oste, Andreas, (eds.) Proceedings Nanophotonics VII; 106720Y (2018) - SPIE Photonics Europe, 2018. SPIE: Strasbourg, France. Green open access

https://ift.tt/2ILOEhA

Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome

Dubourg, L; Vrticka, P; Debbane, M; Chambaz, L; Eliez, S; Schneider, M; (2018) Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders , 10 , Article 13. 10.1186/s11689-018-9232-2 . Green open access

https://ift.tt/2wMtye0

Improving Survival in Pancreatic Cancer with Platinum-Based Chemotherapy

A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations.

https://ift.tt/2rOsd0M

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2IOqQJT

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2wNRz4q

Working while unwell: Workplace impairment in people with severe asthma

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2INPFFO

Threshold dose distribution for cashew nut allergy in children

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2Gr38hK

Management of pediatric orbital cellulitis: A systematic review

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Stephanie J. Wong, Jessica Levi
ObjectivesOrbital complications account for 74–85% of all complications from acute sinusitis, more often affect the pediatric population, and can result in devastating consequences. Therefore these patients require prompt diagnosis and proper management. We review and summarize the current literature to determine the appropriate management of each stage of pediatric orbital cellulitis and offer a new comprehensive literature-based algorithm.MethodsData sources were PubMed/MEDLINE, and Google Scholar. Studies relevant to the management of each subcategory of the Chandler criteria in the pediatric population, limited to the period 1997 through Jan 2018, were compiled and interpreted. Seventy-one studies were reviewed in total.ResultsPre-septal and post-septal cellulitis can generally be managed non-surgically, while orbital abscess and cavernous sinus thrombosis are managed surgically. For subperiosteal abscess, non-surgical medical management has been successful in certain patients. Results of the literature review were summarized, and subsequently developed into a comprehensive algorithm for management, including criteria for age, location, and volume of abscess on imaging.ConclusionsOrbital cellulitis, particularly subperiosteal abscesses, in children is not an absolute indication for immediate surgical intervention. Conservative measures can be safe and effective if appropriately used, depending on patient characteristics, clinical course, and imaging.



https://ift.tt/2IsBsux

Pediatric anosmia: A case series

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Leah J. Hauser, Emily L. Jensen, David M. Mirsky, Kenny H. Chan
IntroductionLittle is known about the etiology of olfactory dysfunction in the pediatric population. The aim of this study is to characterize the etiology and clinical features of anosmia and to explore evaluation options in a pediatric population.MethodsOlfactory dysfunction was identified at a tertiary pediatric hospital between January 2003 and October 2014 using a text-based and ICD-9 search of the electronic health record system. Clinical information gathered included history, physical examination and imaging study. A phone questionnaire was completed to determine persistence and development of other rhinologic, endocrine, or neurologic symptoms.Results37 children (male/female = 17/20) with mean/median ages of 13.28/14. 19 years were identified. The distribution of etiology was: rhinologic disease (N = 16), congenital (N = 4), trauma (N = 1), neoplasm (N = 1) and unknown (N = 15). Rhinologic disease included chronic rhinosinusitis (N = 3) and other nasal anatomic lesions. None of the four subjects with congenital anosmia had classic Kallmann syndrome. The utility of imaging in confirming an etiology of anosmia was noted in 1 of 8 CT and 5 of 22 MRI. The most significant finding of the questionnaire was confirmation of normal puberty in the congenital group.ConclusionSimilar to the adult population, rhinologic disease is the most common cause. Absence or hypoplasia of the olfactory bulbs without associated delayed puberty is the presentation of congenital anosmia in our cohort. MRI had a higher utility than CT in evaluating anosmia in general and congenital anosmia in specific. MRI to evaluate children with a history of congenital olfactory dysfunction is recommended.



https://ift.tt/2rOhkwP

Middle ear disease in Danish toddlers attending nursery day-care – Applicability of OM-6, disease specific quality of life and predictors for middle ear symptoms

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): J.H. Indius, S.K. Alqaderi, A.D. Kjeldsen, C.H. Heidemann
ObjectivesOtitis media (OM) is a very common childhood disease and impacts child quality of life (QoL) to different extends. The aim of this study was to investigate the difference in quality of life between three groups of children; Children with symptoms of ear disease within the last 4 weeks, children without any ear disease and children scheduled for ventilating tube treatment. Furthermore, we investigated predictors for experiencing middle ear symptoms. Lastly, we assessed psychometric properties of OM-6 used to assess QoL.MethodsFour hundred ninety-four children attending nursery day-care aged 6–36 months were enrolled in the study. Caregivers were asked to recall the child's history of symptoms related to middle ear infection. The Danish version of otitis media-6 questionnaire was used to measure the children's quality of life. Data from children treated with ventilating tubes were included from a previously published study. Logistic regression was applied for determining possible predictors for experiencing ear related symptoms.ResultsThe study had an 87% response rate, with a total of 342 children included. At the inclusion 32 (9%) children were included in the 4-week group and, while 307 children were allocated to the non-4 week group. The children in the 4-week group were significantly younger and were more likely to have siblings with a history of middle ear infection than the non-4week group. Furthermore, QoL was significantly worse in the 4-week group compared to the non-4week group. Only subtle differences were found between children with acute symptoms compared to children scheduled for tube treatment.ConclusionsAs expected, children with acute symptoms of OM experience lowered QoL compared to children with no symptoms and young age as well as having siblings with a history of middle ear problems were found to be possible predictors for experiencing middle ear symptoms. Children with acute symptoms differed from children scheduled for ventilating tubes on domains related to long-term problems from OM. OM-6 has shown to be a valid instrument for assessing disease specific QoL in children with OM, however a more large-scale instrument might be necessary for detecting subtle differences between subgroups of children with OM.



https://ift.tt/2IsBenb

Tumour‐like lesions in a Late Bronze Age skeleton from Gonur Depe, Southern Turkmenistan

International Journal of Osteoarchaeology, EarlyView.


https://ift.tt/2ItD6Mo

Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2L7uvRe

The role of Scalpel‐bougie cricothyroidotomy in managing emergency Front of Neck Airway access. A review and technical update for ENT surgeons

Clinical Otolaryngology, Volume 43, Issue 3, Page 791-794, June 2018.


https://ift.tt/2rLYeHI

Issue Information

Clinical Otolaryngology, Volume 43, Issue 3, Page i-iv, June 2018.


https://ift.tt/2GtlCxU

Author Guidelines

Clinical Otolaryngology, Volume 43, Issue 3, Page 997-998, June 2018.


https://ift.tt/2rO9OSq

Successful treatment of cutaneous metastatic melanoma with high‐dose intralesional interleukin‐2 treatment combined with cryosurgery

Dermatologic Therapy, EarlyView.


https://ift.tt/2rRp6F4

Heterogeneity in skin manifestations of spotted fever group rickettsial infection in Australia

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2KvBLp2

Dermatoscopic chaos of border‐abruptness led to diagnosis of a minute melanoma

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2k4d4op

A case of acitretin‐induced haemorrhagic lesions in Darier disease

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2Kt07Q8

Trichoscopy helps to predict the time point of clinical cure of tinea capitis

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2k4cCGJ

Nanoemulsions and dermatological diseases: contributions and therapeutic advances

International Journal of Dermatology, EarlyView.


https://ift.tt/2GrsjRg

Patterns of source monitoring bias in incarcerated youths with and without conduct problems

Morosan, L; Badoud, D; Salaminios, G; Eliez, S; Van der Linden, M; Heller, P; Debbane, M; (2018) Patterns of source monitoring bias in incarcerated youths with and without conduct problems. Cognitive Neuropsychiatry , 23 (1) pp. 15-27. 10.1080/13546805.2017.1412947 .

https://ift.tt/2rPdXW8

Herpesvirus Skin Disease in Free-living Common Frogs (Rana Temporaria) in Great Britain

Franklinos, LHV; Rodriguez-Ramos Fernandez, J; Hydeskov, HB; Hopkins, KP; Everest, DJ; Cunningham, AA; Lawson, B; (2018) Herpesvirus Skin Disease in Free-living Common Frogs (Rana Temporaria) in Great Britain. Diseases of Aquatic Organisms (In press).

https://ift.tt/2IuPig5

Hypothalamic α-synuclein and its relation to weight loss and autonomic symptoms in Parkinson's disease

De Pablo-Fernandez, E; Courtney, R; Holton, JL; Warner, TT; (2017) Hypothalamic α-synuclein and its relation to weight loss and autonomic symptoms in Parkinson's disease. Movement Disorders , 32 (2) pp. 296-298. 10.1002/mds.26868 .

https://ift.tt/2ISVKRg

MSA-C or SCA 17? A clinicopathological case update

Doherty, KM; De Pablo-Fernandez, E; Houlden, H; Polke, JM; Lees, AJ; Warner, TT; Holton, JL; (2016) MSA-C or SCA 17? A clinicopathological case update. Movement Disorders , 31 (10) pp. 1582-1584. 10.1002/mds.26741 .

https://ift.tt/2IvML5q

Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats

Hayman, DTS; Luis, AD; Restif, O; Baker, KS; Fooks, AR; Leach, C; Horton, DL; ... Webb, CT; + view all Hayman, DTS; Luis, AD; Restif, O; Baker, KS; Fooks, AR; Leach, C; Horton, DL; Suu-Ire, R; Cunningham, AA; Wood, JLN; Webb, CT; - view fewer (2018) Maternal antibody and the maintenance of a lyssavirus in populations of seasonally breeding African bats. PLoS ONE (In press).

https://ift.tt/2IR4KGV

Brief assessment of schizotypal traits: A multinational study

Fonseca-Pedrero, E; Ortuño-Sierra, J; Lucas-Molina, B; Debbané, M; Chan, RCK; Cicero, DC; Zhang, LC; ... Voracek, M; + view all Fonseca-Pedrero, E; Ortuño-Sierra, J; Lucas-Molina, B; Debbané, M; Chan, RCK; Cicero, DC; Zhang, LC; Brenner, C; Barkus, E; Linscott, RJ; Kwapil, T; Barrantes-Vidal, N; Cohen, A; Raine, A; Compton, MT; Tone, EB; Suhr, J; Bobes, J; Fumero, A; Giakoumaki, S; Tsaousis, I; Preti, A; Chmielewski, M; Laloyaux, J; Mechri, A; Lahmar, MA; Wuthrich, V; Larøi, F; Badcock, JC; Jablensky, A; Barron, D; Swami, V; Tran, US; Voracek, M; - view fewer (2017) Brief assessment of schizotypal traits: A multinational study. Schizophrenia Research 10.1016/j.schres.2017.10.043 . (In press).

https://ift.tt/2Is4H0J

Autonomic dysfunction in Parkinson's disease: the hidden game changer?

De Pablo Fernandez, E; Warner, T; (2018) Autonomic dysfunction in Parkinson's disease: the hidden game changer? Movement Disorders 10.1002/mds.27422 . (In press).

https://ift.tt/2IJyp4H

Comparisons of schizotypal traits across 12 countries: Results from the International Consortium for Schizotypy Research

Fonseca-Pedrero, E; Chan, RCK; Debbané, M; Cicero, D; Zhang, LC; Brenner, C; Barkus, E; ... Ortuño-Sierra, J; + view all Fonseca-Pedrero, E; Chan, RCK; Debbané, M; Cicero, D; Zhang, LC; Brenner, C; Barkus, E; Linscott, RJ; Kwapil, T; Barrantes-Vidal, N; Cohen, A; Raine, A; Compton, MT; Tone, EB; Suhr, J; Muñiz, J; de Albéniz, AP; Fumero, A; Giakoumaki, S; Tsaousis, I; Preti, A; Chmielewski, M; Laloyaux, J; Mechri, A; Lahmar, MA; Wuthrich, V; Larøi, F; Badcock, JC; Jablensky, A; Ortuño-Sierra, J; - view fewer (2018) Comparisons of schizotypal traits across 12 countries: Results from the International Consortium for Schizotypy Research. Schizophrenia Research 10.1016/j.schres.2018.03.021 . (In press).

https://ift.tt/2Is4ryN

Treating borderline personality disorder with oxytocin: An enthusiastic note of caution. Commentary to Servan et al. The effect of oxytocin in borderline personality disorder

Debbane, M; (2018) Treating borderline personality disorder with oxytocin: An enthusiastic note of caution. Commentary to Servan et al. The effect of oxytocin in borderline personality disorder. L'Encéphale , 44 (1) pp. 83-84. 10.1016/j.encep.2017.12.003 .

https://ift.tt/2rNzoH8

A stretchable and biodegradable strain and pressure sensor for orthopaedic application

Boutry,, CM; Kaizawa, Y; Schroeder, BC; Chortos, A; Legrand, A; Wang, Z; Chang, J; ... Bao, Z; + view all Boutry,, CM; Kaizawa, Y; Schroeder, BC; Chortos, A; Legrand, A; Wang, Z; Chang, J; Fox, P; Bao, Z; - view fewer (2018) A stretchable and biodegradable strain and pressure sensor for orthopaedic application. Nature Electronics , 1 pp. 314-321. 10.1038/s41928-018-0071-7 .

https://ift.tt/2IrGJ5y

Cumana and Antioquia : a comparative study of urban development in colonial Hispanic America

De Chaves, ESA; (1977) Cumana and Antioquia : a comparative study of urban development in colonial Hispanic America. Doctoral thesis (PhD), University of London. Green open access

https://ift.tt/2IN1hJ5

Natural biological variation of white matter microstructure is accentuated in Huntington's disease

Gregory, S; Crawford, H; Seunarine, K; Leavitt, B; Durr, A; Roos, RAC; Scahill, RI; ... Orth, M; + view all Gregory, S; Crawford, H; Seunarine, K; Leavitt, B; Durr, A; Roos, RAC; Scahill, RI; Tabrizi, SJ; Rees, G; Langbehn, D; Orth, M; - view fewer (2018) Natural biological variation of white matter microstructure is accentuated in Huntington's disease. Human Brain Mapping 10.1002/hbm.24191 . (In press). Green open access

https://ift.tt/2IrpjpD

An analysis of the political and aesthetic aspects in the early work of Bestuzhev-Marlinskyn

Landsman, NB; (1969) An analysis of the political and aesthetic aspects in the early work of Bestuzhev-Marlinskyn. UNSPECIFIED thesis (PhD), University of London. Green open access

https://ift.tt/2IN1cVN

Child mortality in England compared with Sweden: a birth cohort study

Zylbersztejn, A; Gilbert, R; Hjern, A; Wijlaars, L; Hardelid, P; (2018) Child mortality in England compared with Sweden: a birth cohort study. The Lancet 10.1016/S0140-6736(18)30670-6 . (In press). Green open access

https://ift.tt/2Itp1i0

Does posh english sound attractive?

Jiao, L; Wang, C; Hsu, C; Birkholz, P; Xu, Y; (2017) Does posh english sound attractive? In: (pp. pp. 2257-2261). International Speech Communication Association (ISCA) Green open access

https://ift.tt/2IQcPvh

Tripolitania under the Roman Empire

Elmayer, AF; (1985) Tripolitania under the Roman Empire. UNSPECIFIED thesis (PhD), University of London. Green open access

https://ift.tt/2IqBPG4

The surface reactivity of acrylonitrile with oxygen atoms on an analogue of interstellar dust grains

Price, SD; Kimber, H; Toscano, J; (2018) The surface reactivity of acrylonitrile with oxygen atoms on an analogue of interstellar dust grains. Monthly Notices of the Royal Astronomical Society , 476 (4) pp. 5332-5340. 10.1093/mnras/sty587 . Green open access

https://ift.tt/2rP1phD

Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motion

Castella, R; Arn, L; Dupuis, E; Callaghan, MF; Draganski, B; Lutti, A; (2018) Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motion. Magnetic Resonance in Medicine 10.1002/mrm.27214 . (In press). Green open access

https://ift.tt/2IqBzqA

Emergency powers in the newly independent African countries in the Commonwealth

Akande, JO; (1971) Emergency powers in the newly independent African countries in the Commonwealth. Doctoral thesis (PhD), University of London. Green open access

https://ift.tt/2rJ5XGn

MM 1A pottery from Evans' excavations at Knossos

Momigliano, N; (1989) MM 1A pottery from Evans' excavations at Knossos. Doctoral thesis (PhD), University of London. Green open access

https://ift.tt/2IttDov

Leukocytoclastic vasculitis associated with immunoglobulin A lambda monoclonal gammopathy of undetermined significance: A case report and review of previously reported cases

The Journal of Dermatology, EarlyView.


https://ift.tt/2rNRUzp

Case of anti‐p200 pemphigoid accompanying uterine malignancy

The Journal of Dermatology, EarlyView.


https://ift.tt/2GpWJ6k

Case of S100‐positive benign cephalic histiocytosis involving monocyte/macrophage lineage marker expression

The Journal of Dermatology, EarlyView.


https://ift.tt/2rMNGYE

Brodalumab‐induced palmar pustular eruption and joint swelling accompanied by muscle pains in two cases of psoriasis

The Journal of Dermatology, EarlyView.


https://ift.tt/2GpWwjy

Issue Information

Head &Neck, Volume 40, Issue 6, Page 1103-1105, June 2018.


https://ift.tt/2k3bUJV

Extracellular interleukin‐17F has a protective effect in oral tongue squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2rP74DI

Are European dermatology patients treated unequally?

British Journal of Dermatology, Volume 178, Issue 5, Page 991-991, May 2018.


https://ift.tt/2wJPiY2

Allocation of biologics: health economics and clinical decision making in plaque psoriasis

British Journal of Dermatology, Volume 178, Issue 5, Page 997-998, May 2018.


https://ift.tt/2IQp8rG

After the approval of dupilumab for moderate‐to‐severe atopic dermatitis: what is next on the research agenda?

British Journal of Dermatology, Volume 178, Issue 5, Page 992-993, May 2018.


https://ift.tt/2wOiVYg

Beyond skin deep: taking bedside dermatology to the next level with noninvasive technologies

British Journal of Dermatology, Volume 178, Issue 5, Page 994-996, May 2018.


https://ift.tt/2ImZjQd

News and Notices

British Journal of Dermatology, Volume 178, Issue 5, Page 1226-1227, May 2018.


https://ift.tt/2GnJxyV

U.K. Psychodermatology Society Annual Meeting, Royal College of Physicians, London, 26 January 2017

British Journal of Dermatology, Volume 178, Issue 5, Page e342-e346, May 2018.


https://ift.tt/2IQoTgg

Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case–control study

British Journal of Dermatology, Volume 178, Issue 5, Page e372-e372, May 2018.


https://ift.tt/2IMM0Io

U.K. Psychodermatology Society Annual Meeting, St Thomas’ Hospital, London, 25 January 2018

British Journal of Dermatology, Volume 178, Issue 5, Page e347-e353, May 2018.


https://ift.tt/2GpaXEp

Issue Information

British Journal of Dermatology, Volume 178, Issue 5, Page i-v, May 2018.


https://ift.tt/2IsnA7B

Analysis of anti‐tumour necrosis factor‐induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics

British Journal of Dermatology, Volume 178, Issue 5, Page e364-e364, May 2018.


https://ift.tt/2wNQaem

Changes in filaggrin degradation products and corneocyte surface texture by season

British Journal of Dermatology, Volume 178, Issue 5, Page e365-e365, May 2018.


https://ift.tt/2IoGnAV

Image Gallery: the new age of dermoscopy: optical super‐high magnification

British Journal of Dermatology, Volume 178, Issue 5, Page e330-e330, May 2018.


https://ift.tt/2wNPWnw

Cellulitis: what to measure, how to define? Systematic review of outcomes from cellulitis trials

British Journal of Dermatology, Volume 178, Issue 5, Page 1000-1001, May 2018.


https://ift.tt/2wNPC8i

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria

British Journal of Dermatology, Volume 178, Issue 5, Page e362-e362, May 2018.


https://ift.tt/2IST5ae

Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial

British Journal of Dermatology, Volume 178, Issue 5, Page e361-e361, May 2018.


https://ift.tt/2GoZrsQ

Inflammatory skin eruptions induced by anti‐tumour necrosis factor‐α therapy differ undeniably from psoriasis or eczema

British Journal of Dermatology, Volume 178, Issue 5, Page 1007-1008, May 2018.


https://ift.tt/2ImVASZ

Pembrolizumab treatment of a patient with xeroderma pigmentosum with disseminated melanoma and multiple nonmelanoma skin cancers

British Journal of Dermatology, Volume 178, Issue 5, Page 1009-1009, May 2018.


https://ift.tt/2GpQL5D

Adjunctive therapy for healing venous leg ulcers

British Journal of Dermatology, Volume 178, Issue 5, Page 1005-1006, May 2018.


https://ift.tt/2Iq9Fii

Image Gallery: Cutaneous findings in Hunter syndrome

British Journal of Dermatology, Volume 178, Issue 5, Page e329-e329, May 2018.


https://ift.tt/2GrhQ8q

Moving core outcome sets in dermatology forward

British Journal of Dermatology, Volume 178, Issue 5, Page 1010-1010, May 2018.


https://ift.tt/2ImVyKR

Toll‐like receptor signalling induces the expression of serum amyloid A in epidermal keratinocytes and dermal fibroblasts

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Gs1MDg

Yellowish papules on the glans

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rOQNiN

Paraneoplastic pemphigus foliaceus related to underlying breast cancer

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2GrHyJT

Improvement in facial discoid dermatosis with calcipotriol/betamethasone ointment and low‐dose acitretin

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IoLv8b

Persistent unilateral ulcer of the ear as the first manifestation of relapsing polychondritis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rQqUOG

Presence of human papillomavirus 16 in acral Bowen disease as a predictor of a less efficacious response to photodynamic therapy: a retrospective case series of nine patients

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rLnFJq

Dermatology on‐call should be commissioned and funded to support acute hospital services

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Gujmqs

Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1–2 and ARVCF, causing renal damage

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rTFkyH

Lichenoid paraneoplastic pemphigus associated with follicular lymphoma without detectable autoantibodies

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2GrJ0Mm

An enlarging pedunculated nodule on the shoulder of a 21‐year‐old man

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IoKgG0

Dermatological aspects of tularaemia: a study of 168 cases

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2rP08pX

Erythema nodosum arising during everolimus therapy for tuberous sclerosis complex

Pediatric Dermatology, EarlyView.


https://ift.tt/2KxCcPw

Dermal non‐neural granular cell tumor in a 3‐year‐old child

Pediatric Dermatology, EarlyView.


https://ift.tt/2k6Yb4S

Hand, foot, and mouth disease photolocalized to sunburn

Pediatric Dermatology, EarlyView.


https://ift.tt/2KsTwFx

Therapeutic interventions to lessen the psychosocial effect of vitiligo in children: A review

Pediatric Dermatology, EarlyView.


https://ift.tt/2k27XoW

Multiple superficial oral mucoceles after Mycoplasma‐induced mucositis

Pediatric Dermatology, EarlyView.


https://ift.tt/2Kz3jKr

Lower lip capillary malformation associated with lymphatic malformation without overgrowth: Part of the spectrum of CLAPO syndrome

Pediatric Dermatology, EarlyView.


https://ift.tt/2k319Hy

Cutaneous fibrolipomatous hamartoma: Report of 2 cases with retrocalcaneal location

Pediatric Dermatology, EarlyView.


https://ift.tt/2KxD9aQ

Hand‐foot‐skin reaction related to use of the multikinase inhibitor sorafenib and hard orthotics

Pediatric Dermatology, EarlyView.


https://ift.tt/2InyPhy

Risk factors for ocular complications in periocular infantile hemangiomas

Pediatric Dermatology, EarlyView.


https://ift.tt/2rPkDml

Erythema multiforme after orf virus infection

Pediatric Dermatology, EarlyView.


https://ift.tt/2rNHyPQ

Surgical treatment strategy in Warthin tumor of the parotid gland

Publication date: Available online 16 May 2018
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul Lim
IntroductionWarthin tumors are the second most common benign tumors of the parotid gland. We examined the clinical features of Warthin tumors in our hospital, and analyzed the consistency within the literatures.ObjectiveThe aim of this study is to analyze the clinical features of Warthin tumors in our 10-year experience of 118 Warthin tumors undergoing surgery at a single institute.MethodsFrom December 2006 to December 2016, 110 patients who underwent surgical treatment for Warthin tumors were identified based on their medical records.ResultsA total of 118 parotid gland operations were performed in 110 patients. Almost 90% of Warthin tumors were found in males, and average patient age was 66.1±6.1 years. The prevalence of smoking history was 89.1% (98/110). Eight patients (7.3%) had bilateral Warthin tumors. Seventy-seven lesions (65.3%) were located in the parotid tail portion, followed by 34 lesions in the superficial lobe (28.8%) and 7 lesions in the deep lobe (5.9%).ConclusionWe determined the appropriate extent of surgery depending on the fine needle aspiration cytology and tumor location by computed tomography scans. Partial facial dysfunction after the operation was detected in 12 cases, and facial nerve function recovered within 3 months. Only one patient experienced a recurrence, and was disease free after the re-operation. We suggest that our treatment algorithm, depending on the location of tumors and the result of fine needle aspiration cytology, can be useful to determine the appropriate extent of surgery for Warthin tumors.



https://ift.tt/2GqzicY

Gender differences in binaural speech-evoked auditory brainstem response: are they clinically significant?

Publication date: Available online 17 May 2018
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Bahram Jalaei, Mohd Hafiz Afifi Mohd Azmi, Mohd Normani Zakaria
IntroductionBinaurally evoked auditory evoked potentials have good diagnostic values when testing subjects with central auditory deficits. The literature on speech-evoked auditory brainstem response evoked by binaural stimulation is in fact limited. Gender disparities in speech-evoked auditory brainstem response results have been consistently noted but the magnitude of gender difference has not been reported.ObjectiveThe present study aimed to compare the magnitude of gender difference in speech-evoked auditory brainstem response results between monaural and binaural stimulations.MethodsA total of 34 healthy Asian adults aged 19–30 years participated in this comparative study. Eighteen of them were females (mean age=23.6±2.3 years) and the remaining sixteen were males (mean age=22.0±2.3 years). For each subject, speech-evoked auditory brainstem response was recorded with the synthesized syllable /da/ presented monaurally and binaurally.ResultsWhile latencies were not affected (p>0.05), the binaural stimulation produced statistically higher speech-evoked auditory brainstem response amplitudes than the monaural stimulation (p<0.05). As revealed by large effect sizes (d>0.80), substantive gender differences were noted in most of speech-evoked auditory brainstem response peaks for both stimulation modes.ConclusionThe magnitude of gender difference between the two stimulation modes revealed some distinct patterns. Based on these clinically significant results, gender-specific normative data are highly recommended when using speech-evoked auditory brainstem response for clinical and future applications. The preliminary normative data provided in the present study can serve as the reference for future studies on this exam among Asian adults.



https://ift.tt/2INprmY

The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases

Publication date: Available online 16 May 2018
Source:Allergology International
Author(s): Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need.The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies. It is a once-daily tablet treatment to be self-administered after the first dose has been provided under the supervision of a physician with experience in the diagnosis and treatment of allergic diseases. Once the first dose is adequately tolerated, subsequent doses may be self-administered. SLIT-tablets have proven efficacy for allergic rhinitis (AR) with and without conjunctivitis (C) and allergic asthma (AA) in adults, children, and poly-sensitized allergic patients. Meta-analyses indicate that SLIT-tablets have superior or similar efficacy compared with anti-allergic pharmacotherapies for seasonal AR and superior efficacy for perennial AR. SLIT-tablets have also demonstrated clinically relevant improvements of asthma, with significant reductions in the following: daily inhaled corticosteroid use, risk of asthma exacerbations, and asthma symptoms. SLIT-tablets are generally well tolerated, with a low risk of systemic allergic reactions. The most common treatment-related adverse events are mild-moderate oral reactions. Current evidence supports SLIT-tablets to be considered as an alternative or add-on treatment to pharmacotherapy for AR/C and asthma. Future SLIT developments may include early intervention to prevent the development or progression of allergic disease in children.



https://ift.tt/2wKFu08

Case 15-2018: An 83-Year-Old Woman with Nausea, Vomiting, and Confusion

Presentation of Case. Dr. Andrew S. Hoekzema (Medicine): An 83-year-old woman was admitted to this hospital in the winter because of nausea, vomiting, diarrhea, and confusion. One week before admission, rhinorrhea, sore throat, and nonproductive cough developed. The patient felt feverish but did…

https://ift.tt/2Ky3lCf

Malignes Melanom − Früherkennung, Diagnostik und Nachsorge

Zusammenfassung

Hintergrund

Das maligne Melanom ist eine häufige Hautkrebsart mit einer sehr hohen Mortalität. In Europa versterben jährlich etwa 22.000 Menschen daran, davon etwa 2700 Patienten alleine in Deutschland. Die Inzidenz zeigt seit Jahren eine steigende Tendenz. Bedeutende Risikofaktoren für die Entstehung eines malignen Melanoms sind die Anzahl der melanozytären Nävi am Körper, eine positive Familienanamnese für Melanom und genetische Prädisposition.

Ziel

In dieser Arbeit soll auch dem Nichtdermatoonkologen eine Übersicht über die Diagnostik, Behandlung, Stadieneinteilung und Nachsorge des malignen Melanoms vermittelt werden.

Material und Methoden

Es wurde eine selektive Literaturrecherche in Medline über Pubmed erstellt und mit eigenen Erfahrungen der Autoren ergänzt.

Ergebnisse

Es werden 4 klinische Formen des Melanoms unterschieden: superfiziell spreitende Melanome (SSM), Lentigo-maligna-Melanome (LMM), akral-lentiginöse Melanome (ALM) und noduläre Melanome (NM). Diese unterscheiden sich sowohl in ihrem klinischen Erscheinungsbild, ihrer Lokalisation und Entwicklung und letztlich auch ihrer Prognose, die für das ALM und NM am ungünstigsten ist. Zur Diagnosesicherung und zur klinischen und pathologischen Stadieneinteilung ist eine operative Erstversorgung von kutanen Melanomen unerlässlich. Ab einer Tumordicke nach Breslow über 1 mm wird die diagnostische Exzision des Wächterlymphknotens (WLK) empfohlen. Bei Befall des WLK sollte zunächst eine Ausbreitungsdiagnostik mittels Schnittbildgebung erfolgen. Ist eine Exzision und Nachexzision und ggf. die WLK-Biopsie erfolgt, wird eine stadiengerechte Ausbreitungsdiagnostik empfohlen. Die empfohlene Nachsorge des malignen Melanoms gestaltet sich stadienadaptiert und entsprechend der aktuellen Leitlinie.

https://ift.tt/2wMvxiu

Comparative Post-operative Pain Analysis Between Coblator Assisted and Bipolar Diathermy Tonsillectomy in Paediatric Patients

Abstract

Tonsillectomy is one of the commonly performed otolaryngological operations. Despite a range of different techniques post-operative pain remains a major side-effect of this operation. Coblation assisted tonsillectomy is a latest technique of tonsillectomy. This technique is said to be associated with less intra-operative bleeding and less postoperative morbidity. We conducted a study in 100 patients to compare the pain scores between coblation assisted and bipolar diathermy tonsillectomy by FLACC score and Wong Baker scale score. The data so collected was statistically analysed using a t test and p values were calculated. The p value was highly significant (p < 0.001) for both scores in coblation assisted tonsillectomy 6 h postoperatively and on 1st postoperative day (p < 0.05). On 7th post-operative day however there was no significant difference in post-operative pain score using FLACC score in both groups but Wong baker scale scores were still significant. We concluded that post-operative pain was less with coblator assisted tonsillectomy as compared to bipolar diathermy tonsillectomy at least in early post-operative period.

https://ift.tt/2IvP9cp

Comparative Post-operative Pain Analysis Between Coblator Assisted and Bipolar Diathermy Tonsillectomy in Paediatric Patients

Abstract

Tonsillectomy is one of the commonly performed otolaryngological operations. Despite a range of different techniques post-operative pain remains a major side-effect of this operation. Coblation assisted tonsillectomy is a latest technique of tonsillectomy. This technique is said to be associated with less intra-operative bleeding and less postoperative morbidity. We conducted a study in 100 patients to compare the pain scores between coblation assisted and bipolar diathermy tonsillectomy by FLACC score and Wong Baker scale score. The data so collected was statistically analysed using a t test and p values were calculated. The p value was highly significant (p < 0.001) for both scores in coblation assisted tonsillectomy 6 h postoperatively and on 1st postoperative day (p < 0.05). On 7th post-operative day however there was no significant difference in post-operative pain score using FLACC score in both groups but Wong baker scale scores were still significant. We concluded that post-operative pain was less with coblator assisted tonsillectomy as compared to bipolar diathermy tonsillectomy at least in early post-operative period.

https://ift.tt/2IvP9cp

Promoting uptake of flexible sigmoidoscopy 'bowel scope' screening at St Mark's Hospital in London

Kerrison, Robert Stephen; (2018) Promoting uptake of flexible sigmoidoscopy 'bowel scope' screening at St Mark's Hospital in London. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2rN5EKy

Miniature Broadband-NIRS System to Measure CNS Tissue Oxygenation and Metabolism in Preclinical Research

Kaynezhad, Pardis; (2018) Miniature Broadband-NIRS System to Measure CNS Tissue Oxygenation and Metabolism in Preclinical Research. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2rPNRS8

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

Tiberi, S; du Plessis, N; Walzl, G; Vjecha, MJ; Rao, M; Ntoumi, F; Mfinanga, S; ... Zumla, A; + view all Tiberi, S; du Plessis, N; Walzl, G; Vjecha, MJ; Rao, M; Ntoumi, F; Mfinanga, S; Kapata, N; Mwaba, P; McHugh, TD; Ippolito, G; Migliori, GB; Maeurer, MJ; Zumla, A; - view fewer (2018) Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies. The Lancet Infectious Diseases 10.1016/S1473-3099(18)30110-5 . (In press).

https://ift.tt/2rLF0lk

Non-invasive technique for determining local pulse wave velocity in humans ascending aorta

Negoita, M; Hughes, AD; Parker, KH; Khir, AW; (2017) Non-invasive technique for determining local pulse wave velocity in humans ascending aorta. In: Murray, Alan, (ed.) Proceedings of the Computing in Cardiology (CinC) - 2017. Universite De Rennes: Rennes, France.

https://ift.tt/2GqNIKf

Impact of pre-transplant time on dialysis on survival in patients with lupus nephritis

Ntatsaki, E; Velo-Garcia, A; Vassiliou, V; Salama, A; Isenberg, D; (2018) Impact of pre-transplant time on dialysis on survival in patients with lupus nephritis. Clinical Rheumatology 10.1007/s10067-018-4115-1 . (In press). Green open access

https://ift.tt/2InNtp9

Can somatic GATA2 mutation mimic germ line GATA2 mutation?

Sekhar, M; Pocock, R; Lowe, D; Mitchell, C; Marafioti, T; Dickinson, R; Collin, M; Sekhar, M; Pocock, R; Lowe, D; Mitchell, C; Marafioti, T; Dickinson, R; Collin, M; Lipman, M; - view fewer (2018) Can somatic GATA2 mutation mimic germ line GATA2 mutation? Blood Advances , 2 (8) pp. 904-908. 10.1182/bloodadvances.2017012617 . Green open access

https://ift.tt/2rQbMkB

A simplified method to account for wall motion in patient-specific blood flow simulations of aortic dissection: Comparison with fluid-structure interaction

Bonfanti, M; Balabani, S; Alimohammadi, M; Agu, O; Homer-Vanniasinkam, S; Diaz, V; (2018) A simplified method to account for wall motion in patient-specific blood flow simulations of aortic dissection: Comparison with fluid-structure interaction. Medical Engineering and Physics 10.1016/j.medengphy.2018.04.014 . (In press).

https://ift.tt/2rNcsYP

IDEA intervention to prevent depressive symptoms and promote well-being in early-stage dementia: protocol for a randomised controlled feasibility study

Tuijt, R; Livingston, G; Gould, RL; Jones, R; Verdaguer, ES; Orgeta, V; (2018) IDEA intervention to prevent depressive symptoms and promote well-being in early-stage dementia: protocol for a randomised controlled feasibility study. BMJ Open , 8 (2) , Article e021074. 10.1136/bmjopen-2017-021074 . Green open access

https://ift.tt/2rPR83Q

Screening Programs for Abdominal Aortic Aneurysms: Luxury or Necessity?

Paraskevas, KI; Brar, R; Constantinou, J; Tsui, J; Baker, DM; (2018) Screening Programs for Abdominal Aortic Aneurysms: Luxury or Necessity? Angiology 10.1177/0003319718766740 . (In press). Green open access

https://ift.tt/2rN5uCW

Comparison of Cu-Mg-Al-Ox and Cu/Al2O3 in selective catalytic oxidation of ammonia (NH3-SCO)

Jabłońska, M; Wolkenar, B; Beale, AM; Pischinger, S; Palkovits, R; (2018) Comparison of Cu-Mg-Al-Ox and Cu/Al2O3 in selective catalytic oxidation of ammonia (NH3-SCO). Catalysis Communications , 110 pp. 5-9. 10.1016/j.catcom.2018.03.003 .

https://ift.tt/2rQbLNz

A method to predict magnetopause expansion in radial IMF events by MHD simulations

Samsonov, AA; Sibeck, DG; Safrankova, J; Nemecek, Z; Shue, J-H; (2017) A method to predict magnetopause expansion in radial IMF events by MHD simulations. Journal of Geophysical Research: Space Physics , 122 (3) pp. 3110-3126. 10.1002/2016JA023301 . Green open access

https://ift.tt/2rT1L79

Residential proximity to major roads and cognitive function in asymptomatic children with Sickle Cell Anaemia: a longitudinal study

Smith, C; Kawadler, J; Kirkham, F; Hogan, A; Telfer, P; Stotesbury, H; (2018) Residential proximity to major roads and cognitive function in asymptomatic children with Sickle Cell Anaemia: a longitudinal study. Presented at: 58th Annual Scientific Meeting of the British-Society-for-Haematology, Liverpool, UK.

https://ift.tt/2rPR6Jg

Placenta accreta spectrum disorders: A new standardized terminology better defining the condition

Matsubara, S; Jauniaux, E; (2018) Placenta accreta spectrum disorders: A new standardized terminology better defining the condition. Journal of Obstetrics and Gynaecology Research 10.1111/jog.13649 . (In press).

https://ift.tt/2IofWvd

Does auto-adjusting positive airway pressure (APAP) aid memory and learning in children with sickle cell disease and sleep disordered-breathing?

Kolbel, M; Stotesbury, H; Kawadler, J; Howard, J; Inusa, B; Rees, D; Chakravorty, S; ... Slee, A; + view all Kolbel, M; Stotesbury, H; Kawadler, J; Howard, J; Inusa, B; Rees, D; Chakravorty, S; Pelidis, M; Thein, SL; Kirkham, F; Slee, A; - view fewer (2018) Does auto-adjusting positive airway pressure (APAP) aid memory and learning in children with sickle cell disease and sleep disordered-breathing? Presented at: 58th Annual Scientific Meeting of the British-Society-for-Haematology, Liverpool, UK.

https://ift.tt/2Gpya9F

FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management

Allen, L; Jauniaux, E; Hobson, S; Papillon-Smith, J; Belfort, MA; FIGO Placenta Accreta Diagnosis and Management Expert Consensus, .; (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Nonconservative surgical management. International Journal of Gynecology & Obstetrics , 140 (3) pp. 281-290. 10.1002/ijgo.12409 .

https://ift.tt/2rO8LC1

FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction

Jauniaux, E; Ayres-de-Campos, D; (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Introduction. International Journal of Gynecology & Obstetrics , 140 (3) pp. 261-264. 10.1002/ijgo.12406 .

https://ift.tt/2Gr5OvC

FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology

Jauniaux, E; Chantraine, F; Silver, RM; Langhoff-Roos, J; (2018) FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology. International Journal of Gynecology & Obstetrics , 140 (3) pp. 265-273. 10.1002/ijgo.12407 .

https://ift.tt/2IqiRDy

Prevention of Morbidity in Sickle Cell Disease Phase 2 (POMS 2b pediatric): Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: a single-blind, randomized, controlled phase II trial

Slee, A; Stotesbury, H; Kawadler, J; Koelbel, M; Chakravorty, S; Pelidis, M; Thein, SL; ... Kirkham, F; + view all Slee, A; Stotesbury, H; Kawadler, J; Koelbel, M; Chakravorty, S; Pelidis, M; Thein, SL; Howard, J; Rees, D; Sahota, S; Sarkaria, S; Nwosu, C; Saunders, D; Gavlak, J; Gupta, A; Liossi, C; Kirkham, F; - view fewer (2018) Prevention of Morbidity in Sickle Cell Disease Phase 2 (POMS 2b pediatric): Improvement of Cognition in children with Sickle Cell Disease with Auto-adjusting Continuous Positive Airways Pressure: a single-blind, randomized, controlled phase II trial. Presented at: 58th Annual Scientific Meeting of the British-Society-for-Haematology, Liverpool, UK.

https://ift.tt/2rQbIkR

New insights in the pathophysiology of complete hydatidiform mole

Jauniaux, E; Memtsa, M; Johns, J; Ross, JA; Jurkovic, D; (2018) New insights in the pathophysiology of complete hydatidiform mole. Placenta , 62 pp. 28-33. 10.1016/j.placenta.2017.12.008 .

https://ift.tt/2rOLz6A

The Rate of Cervical Length Shortening in the Management of Vasa Previa

Maymon, R; Melcer, Y; Tovbin, J; Pekar-Zlotin, M; Smorgick, N; Jauniaux, E; (2018) The Rate of Cervical Length Shortening in the Management of Vasa Previa. Journal of Ultrasound in Medicine , 37 (3) pp. 717-723. 10.1002/jum.14411 .

https://ift.tt/2rQ4HQT