Αρχειοθήκη ιστολογίου

Τρίτη 30 Ιανουαρίου 2018

Neutrophilia, gelatinase release and microvascular leakage induced by human mast cell tryptase in a mouse model: Lack of a role of protease activated receptor 2 (PAR2)

Abstract

Background

Tryptase, the most abundant protease of the human mast cell, has been implicated as a key mediator of allergic inflammation that acts through activation of PAR2.

Objectives

To investigate the contribution of PAR2 in the pro-inflammatory actions mediated by tryptase in a mice model.

Methods

We have injected recombinant human βII-tryptase into the peritoneum of PAR2-deficient and wild-type C57BL/6 mice. After 6, 12 and 24 hours mice were euthanized, peritoneal lavage performed and inflammatory changes investigated.

Results

Tryptase stimulated an increase in neutrophil numbers in the peritoneum, but responses did not differ between PAR2-deficient and wild-type mice. Heat-inactivation of tryptase or pre-incubation with a selective tryptase inhibitor reduced neutrophilia, but neutrophil accumulation was not elicited with a peptide agonist of PAR2 (SLIGRL-NH2). Zymography indicated that tryptase stimulated the release of matrix metalloproteinases (MMP) 2 and 9 in the peritoneum of both mouse strains. Studies involving immunomagnetic isolation of neutrophils suggested that neutrophils represent the major cellular source of tryptase-induced MMP2 and MMP9. At 24 h after tryptase injection there was increased microvascular leakage as indicated by high levels of albumin in peritoneal lavage fluid, and this appeared to be partially abolished by heat-inactivating tryptase or addition of a protease inhibitor. There was no corresponding increase in levels of histamine or total protein. The extent of tryptase-induced microvascular leakage or gelatinase release into the peritoneum did not differ between PAR2-deficient and wild-type mice.

Conclusions

Our findings indicate that tryptase is a potent stimulus for neutrophil accumulation, MMP release and microvascular leakage. Though these actions required an intact catalytic site, the primary mechanism of tryptase in vivo would appear to involve processes independent of PAR2.

This article is protected by copyright. All rights reserved.



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Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic symptoms

Abstract

IgE responses against allergens have acquired much attention due to their pathogenic nature as mediators of allergic reactions. In contrast, IgE responses against vaccines like Diphtheria-Tetanus-Pertussis (DTP) and the potential persistence of IgE production have received relatively little attention, presumably because of the low prevalence of allergic symptoms. In general, common early sensitivity reactions against vaccines, including tetanus toxoid, consist of mild local reactions and are not contraindicative of future vaccinations (1, 2).

This article is protected by copyright. All rights reserved.



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Step-down of inhaled corticosteroids in non-eosinophilic asthma: a prospective trial in real life

Abstract

Background

While non-eosinophilic asthmatics are usually considered poorly responsive to inhaled corticosteroids (ICS), studies assessing a step-down of ICS in this specific population are currently lacking.

Objectives

To assess the proportion of non-eosinophilic asthmatics in whom ICS may be withdrawn without any clinical degradation and to determine the predictive markers of a failure to stop treatment with ICS.

Methods

This prospective study was completed by 36 non-eosinophilic asthmatics, defined by sputum eosinophils <3% and blood eosinophils <400/μL. In these patients, whichever the baseline asthma control level, the dose of ICS was gradually reduced every 3 months until they met the failure criteria or successfully discontinued ICS for 6 months. The failure criteria were an ACQ score ≥1.5 with an increase from baseline >0.5 or a number of severe exacerbations during the study which was greater than the number during the year prior to the baseline visit. Receiver-operating characteristic (ROC) curves were constructed to assess predictors of a failure to stop ICS. This study is registered with ClinicalTrials. gov, number NCT02169323.

Results

In 14 patients (39%), ICS were completely withdrawn and in 10 further patients (28%), ICS were stepped-down to a reduced ICS dose without any deterioration of asthma control and exacerbation rate. Baseline predictors of a failure to stop ICS were a greater age (area under ROC curve [ROC AUC] and [95% CI]: 0.77 [0.62-0.93]) and elevated blood eosinophils (ROC AUC [95% CI]: 0.77 [0.61-0.93]). After the first step-down of ICS, the best predictor was an elevated blood eosinophil count (ROC AUC [95% CI]: 0.85 [0.72-0.99]).

Conclusions & Clinical Relevance

Withdrawing or reducing the dose of ICS is feasible in two thirds of non-eosinophilic asthmatics irrespective of baseline asthma control. An elevated blood eosinophil count may predict the failure to stop ICS.

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Temperature-controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open-label, proof-of-concept study

Abstract

Background

Children with severe, persistent atopic eczema (AE) have limited treatment options, often requiring systemic immunosuppression.

Objective

To evaluate the effect of the temperature-controlled laminar airflow (TLA) treatment in children/adolescents with severe AE.

Methods

We recruited 15 children aged 2-16 years with longstanding, severe AE and sensitization to ≥1 perennial inhalant allergen. Run-in period of 6-10 weeks (3 visits), was followed by 12-month treatment with overnight TLA (Airsonett®, Sweden). The primary outcome was eczema severity (SCORAD-Index and Investigator Global Assessment-IGA). Secondary outcomes included child/family dermatology quality of life and family impact questionnaires (CDQLI, FDQLI, DFI), patient oriented eczema measure (POEM), medication requirements, and healthcare contacts. The study is registered as ISRCTN65865773.

Results

There was a significant reduction in AE severity ascertained by SCORAD and IGA during the 12-month intervention period (P<0.001). SCORAD was reduced from a median of 34.9 [interquartile range 28.75-45.15] at baseline to 17.2 [12.95-32.3] at the final visit, and IGA improved significantly from 4 [3-4] to 2 [1-3]. We observed a significant improvement in FDQLI (16.0 [12.25-19.0] to 12 [8-18], P=0.023) and DFI (P=0.011), but not CDQLI or POEM. Compared to 6-month period prior to enrollment, there was a significant reduction at six months after the start of the intervention in potent topical corticosteroids (P=0.033). The exploratory cluster analysis revealed two strongly divergent patterns of response, with 9 patients classified as responders, and 6 as non-responders.

Conclusion and Clinical Relevance

Addition of TLA device to standard pharmacological treatment may be an effective add-on to the management of difficult-to-control AE.

This article is protected by copyright. All rights reserved.



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Refeeding syndrome in adults with celiac crisis: a case report

Refeeding syndrome is a rare and life-threatening pathology with polyvisceral manifestations occurring in severely malnourished patients. It is rarely described in adults with celiac disease.

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Intestinal endometriosis combined with colorectal cancer: a case series

Intestinal endometriosis is a common benign disease among menstruating women that affects the intestinal tract.

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Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature

Muckle-Wells syndrome (MWS) is a rare auto-inflammatory disease characterized by the presence of recurrent urticaria, deafness and amyloidosis. Progressive sensorineural hearing loss (SNHL) is reported to occu...

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The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature

HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remai...

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International consensus (ICON) on treatment of Ménière's disease

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Publication date: Available online 12 January 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): J. Nevoux, M. Barbara, J. Dornhoffer, W. Gibson, T. Kitahara, V. Darrouzet
ObjectiveTo present the international consensus for recommendations for Ménière's disease (MD) treatment.MethodsBased on a literature review and report of 4 experts from 4 continents, the recommendations have been presented during the 21st IFOS congress in Paris, in June 2017 and are presented in this work.ResultsThe recommendation is to change the lifestyle, to use the vestibular rehabilitation in the intercritic period and to propose psychotherapy. As a conservative medical treatment of first line, the authors recommend to use diuretics and Betahistine or local pressure therapy. When medical treatment fails, the recommendation is to use a second line treatment, which consists in the intratympanic injection of steroids. Then as a third line treatment, depending on the hearing function, could be either the endolymphatic sac surgery (when hearing is worth being preserved) or the intratympanic injection of gentamicin (with higher risks of hearing loss). The very last option is the destructive surgical treatment labyrinthectomy, associated or not to cochlear implantation or vestibular nerve section (when hearing is worth being preserved), which is the most frequent option.



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Epiglottoplasty technique in endoscopic partial laryngectomy

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Publication date: Available online 12 January 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): M. Moulin, C.A. Righini, P.F. Castellanos, I. Atallah
The main advantage of endoscopic laser surgery for laryngeal cancer is to allow tumour resection, while limiting functional sequelae, thereby improving the postoperative course. In this type of surgery, the epiglottis is often partially resected, leaving a raw zone without any reconstruction. The surgical technique described here involves endoscopic reconstruction of the epiglottis after partial resection. The sectioned edge of the epiglottis is sutured to the base of the tongue to create a neoepiglottis and to reconstruct the vallecula, thus resembling preoperative anatomy, allowing improvement of postoperative swallowing.



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Meningeal marginal zone B-cell lymphoma: The meningioma trap

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Publication date: Available online 10 January 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): Alexandre Villeneuve, François Rubin, Pierre Bonfils
ObjectiveTo report a case of marginal zone MALT lymphoma of the temporal dura mater, initially mistaken for temporal meningioma.Case reportA 60-year-old immunocompetent woman, followed for more than 10 years for temporal meningioma causing vertigo and mixed hearing loss, presented with cervical lymphadenopathy, revealing marked progression of an intracranial lesion, leading to a diagnosis of marginal zone MALT lymphoma based on histological examination of a cervical lymph node. Treatment with 6 cycles of rituximab and bendamustine allowed complete remission of cervical lymph node and intracranial lesions, confirming the diagnosis of temporal dural mater lymphoma.ConclusionPrimary dural lymphoma must be part of the differential diagnosis of meningioma. Long-term follow-up allows correction of the diagnosis.



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Physiology of the paransal sinus ostia: Endoscopic findings

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Publication date: Available online 12 January 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): R. Jankowski, C. Rumeau




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Storytelling With Your Children

Stories are everywhere.  Newspapers, books, TV shows, movies, artwork,  social media,  sermons/homilies and so on.  Stories are a form of social communication – a way to share our lives with one another – our thoughts, feelings, and experiences.  Storytelling is universal to humans and present in all cultures.  So what does this have to do with parenting or your child?

Storytelling is a great developmental activity.  This may include telling stories to your child, teaching your child how to tell a story, making up stories together, and actively listening to your child while they tell (or attempt to tell) a story.

Here are my top 12 reasons to engage in storytelling with your children:

12) It's an activity that has no age-limits.  For babies or younger children, start by telling them stories.  Make up fictional stories, recall stories about your childhood, or bring up happy family memories.  If it's hard to get your creative juices flowing, use the basic storyline of a fairytale or other classic story and tweak it.  Change the setting.  Add in family members and your child – kids love when stories are about them!  Have your toddler or preschooler take a turn adding to your story- and answering basic questions about who the story should be about, where it should take place, and what should happen.  Encourage grade school-age children to tell stories on their own or recall their favorite parts of the day or other memories. Adolescents should be able to tell more elaborate and detailed stories that interest them.

11) You can do it anywhere.  At the children's area in my local library, my preschool son's favorite spot is the puppet theater where he enjoys making up stories for me and anyone who will listen.  In reality, storytelling can take place in any setting.  You can use it to pass the time in a waiting room, during road-trips, or part of your daily routine – such as at bedtime.  My husband has made storytelling part of his goodnight ritual with our kids.  Their favorites are the silly stories from his childhood, such as the one where Uncle Steve wandered off and was eventually found in his diaper eating dandelions.

10) It's free. It doesn't require any materials or any museum memberships, just human interaction and an imagination.

9)  It doesn't require advanced planning or talent.  Inspiration from stories can come from anywhere – memories of your childhood, family traditions, recent books or films you've shared with your child, etc.

8) Any member of the family can participate.  It's a great way for children to connect with extended family members or family from a different generation.  My father-in-law, "Poppy," loves to relive his "glory days" of playing basketball in college and his memories of great-grandparents with his grandchildren.  And they love to listen and ask lots of questions.

7) It's a great way to introduce or practice key narrative concepts.  For younger children, you can emphasize the importance of having a beginning, middle, and end.  For grade-school kids, you can discuss literary elements, such as lead characters (e.g., protagonist, antagonist), settings, plot, and theme. With older children and adolescents, you can bring up more advanced literary techniques, such as metaphor, simile, alliteration, hyperbole, etc.  It may be kind of fun to dig out some of that knowledge you have stored in your brain from your high school English class.

6) For budding artists or children who thrive on tactile or hands-on activities, it's easy to incorporate art (sketching, drawing, coloring, painting, etc.), crafts, and use of puppets, dolls, stuffed animals or action figures into storytelling.

5) For active children who have difficulty maintaining focus or sitting still, you can involve physical movements and encourage acting out the story to accompany verbal story-telling.

4) Storytelling promotes sustained attention and higher-order executive functioning skills, including working memory (keeping information in mind while doing something with it), mental shifting, planning, and organization.

3) It encourages language development, including verbal expression, vocabulary, sentence syntax, and listening comprehension.  When you tell your child a story, break periodically and ask them questions to gage their attention, interest, and understanding.  When your child tells a story, help them build upon it by asking who, what, where, why, and how questions to encourage descriptive language and critical thinking.

2) It's a great way to share life lessons, moral values, and family/spiritual/religious beliefs in a way that your child can relate to, appreciate, and more effectively remember over time.

1) Storytelling is a great way to spend quality time with your child.  In this fast-paced world full of electronic gadgets and deadlines, one simple yet profound thing you can do for your children is to give them your undivided attention. Listen to them, make them feel worthwhile, and tell them a story.

 

 

The post Storytelling With Your Children appeared first on ChildrensMD.



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Reply to De Dreu: Shared partner nationality promotes ingroup favoritism in cooperation [Social Sciences]

In Romano et al. (1), we report an experimental study conducted across 17 societies that found that individuals gave more in the trust game to ingroup members (partner from own nationality), compared with outgroup members (partner from one of the other 16 nationalities) and strangers (partner with unknown nationality). This...

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Giving decision-makers nondiagnostic person information promotes trust within and across nations [Social Sciences]

Humans trust others, enabling them to negotiate agreement and to create long-term bonds (1). However, because trusting others makes people vulnerable to exploitation, it is difficult to see how indiscriminate trust could have evolved (2–4). Romano et al. (2) suggest a solution to this conundrum. Fitting evolutionary theory (3, 4),...

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Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory [Neuroscience]

All of the cerebral cortex has some degree of laminar organization. These different layers are composed of neurons with distinct connectivity patterns, embryonic origins, and molecular profiles. There are little data on the laminar specificity of cognitive functions in the frontal cortex, however. We recorded neuronal spiking/local field potentials (LFPs)...

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Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility [Neuroscience]

Behavioral coping strategies are critical for active resilience to stress and depression; here we describe a role for neuroligin-2 (NLGN-2) in the nucleus accumbens (NAc). Neuroligins (NLGN) are a family of neuronal postsynaptic cell adhesion proteins that are constituents of the excitatory and inhibitory synapse. Importantly, NLGN-3 and NLGN-4 mutations...

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Learning to make external sensory stimulus predictions using internal correlations in populations of neurons [Neuroscience]

To compensate for sensory processing delays, the visual system must make predictions to ensure timely and appropriate behaviors. Recent work has found predictive information about the stimulus in neural populations early in vision processing, starting in the retina. However, to utilize this information, cells downstream must be able to read...

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Repetitive aggressive encounters generate a long-lasting internal state in Drosophila melanogaster males [Neuroscience]

Multiple studies have investigated the mechanisms of aggressive behavior in Drosophila; however, little is known about the effects of chronic fighting experience. Here, we investigated if repeated fighting encounters would induce an internal state that could affect the expression of subsequent behavior. We trained wild-type males to become winners or...

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Human airway branch variation and chronic obstructive pulmonary disease [Medical Sciences]

Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and...

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Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement [Neuroscience]

Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, whole-transcriptome resource of...

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Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition [Chemistry]

SpnF is the first monofunctional Diels–Alder/[6+4]-ase that catalyzes a reaction leading to both Diels–Alder and [6+4] adducts through a single transition state. The environment-perturbed transition-state sampling method has been developed to calculate free energies, kinetic isotope effects, and quasi-classical reaction trajectories of enzyme-catalyzed reactions and the uncatalyzed reaction in water....

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MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape [Microbiology]

Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined...

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Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites [Biochemistry]

Membrane contact sites (MCSs) in eukaryotic cells are hotspots for lipid exchange, which is essential for many biological functions, including regulation of membrane properties and protein trafficking. Lipid transfer proteins anchored at membrane contact sites (LAMs) contain sterol-specific lipid transfer domains [StARkin domain (SD)] and multiple targeting modules to specific...

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Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division [Developmental Biology]

The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show that Caenorhabditis elegans APR-1/APC is an attenuator of the pulling...

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Molecular characterization of latent GDF8 reveals mechanisms of activation [Biochemistry]

Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small-angle X-ray scattering and mutagenesis, we characterized the interactions of GDF8 with its prodomain. Our results show that the prodomain:GDF8...

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HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice [Medical Sciences]

Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in cancer metastasis is unknown. Here, we show that osteoprogenitor cells...

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HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome [Biochemistry]

Mutations in CDCA7, the SNF2 family protein HELLS (LSH), or the DNA methyltransferase DNMT3b cause immunodeficiency–centromeric instability–facial anomalies (ICF) syndrome. While it has been speculated that DNA methylation defects cause this disease, little is known about the molecular function of CDCA7 and its functional relationship to HELLS and DNMT3b. Systematic...

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Linked networks for learning and expressing location-specific threat [Neuroscience]

Learning locations of danger within our environment is a vital adaptive ability whose neural bases are only partially understood. We examined fMRI brain activity while participants navigated a virtual environment in which flowers appeared and were "picked." Picking flowers in the danger zone (one-half of the environment) predicted an electric...

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Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells [Biochemistry]

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus a high priority for cancer research. An attractive strategy for disabling Mcl-1...

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Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis [Plant Biology]

Genome-wide characterization by next-generation sequencing has greatly improved our understanding of the landscape of epigenetic modifications. Since 2008, whole-genome bisulfite sequencing (WGBS) has become the gold standard for DNA methylation analysis, and a tremendous amount of WGBS data has been generated by the research community. However, the systematic comparison of...

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Crystal structure of the mammalian lipopolysaccharide detoxifier [Biochemistry]

LPS is a potent bacterial endotoxin that triggers the innate immune system. Proper recognition of LPS by pattern-recognition receptors requires a full complement of typically six acyl chains in the lipid portion. Acyloxyacyl hydrolase (AOAH) is a host enzyme that removes secondary (acyloxyacyl-linked) fatty acids from LPS, rendering it immunologically...

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A Novel Surgical Approach to Nasolabial Fistula

Abstract

Infection of hair follicle is commonly called 'boil' or furunculosis. This can result in abscess formation leading to accumulation of pus and necrotic tissue. This can be more common in immunocompromised patients such as uncontrolled diabetes mellitus. Commonest organism to cause furunculosis is believed to be Staphylococcus aureus. We present an elderly patient where multiple nasal vestibular furunculosis suppurated resulting in extensive tissue damage and nasolabial fistula. Reconstruction was delayed to accommodate tissue healing from hyperglycemic insult and necrosis. Alar advancement flap was employed to give a suitable 3 layer closure to the fistula.



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A Novel Surgical Approach to Nasolabial Fistula

Abstract

Infection of hair follicle is commonly called 'boil' or furunculosis. This can result in abscess formation leading to accumulation of pus and necrotic tissue. This can be more common in immunocompromised patients such as uncontrolled diabetes mellitus. Commonest organism to cause furunculosis is believed to be Staphylococcus aureus. We present an elderly patient where multiple nasal vestibular furunculosis suppurated resulting in extensive tissue damage and nasolabial fistula. Reconstruction was delayed to accommodate tissue healing from hyperglycemic insult and necrosis. Alar advancement flap was employed to give a suitable 3 layer closure to the fistula.



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Nasal valve evaluation in the Mexican-Hispanic (mestizo) nose

Background

Our aim in this study was to determine the angle of the internal nasal valve in Mexican patients with the "mestizo nose" feature and without nasal obstructive symptoms. The work was prospective, comparative, and observational in nature and included patients >14 years of age who were seen in the Otolaryngology Department at the Los Angeles Lomas Hospital between April and May 2016.

Methods

The angle of the internal nasal valve was measured in 30 patients without obstructive symptoms. Endoscopic examination was performed with a 0° endoscope framed with tape at a 13-mm distance from the endoscope's tip, and digital photographs of the internal nasal valve were taken. The measurement of the angle of the internal nasal valve was made in sexagesimal degrees using Golden Ratio v3.1 (2012) software. Statistical analysis was performed using Excel v15.13.3.

Results

The angles of the internal nasal valve of the patients were (mean ± standard deviation) 24.07 ± 4.8° for the right nasal cavity and 25.07 ± 5.0° for the left nasal cavity, wider than the angle reported in the normal Caucasian nose established in the literature.

Conclusions

According to our results, the Mexican-Hispanic mestizo nose has a wider angle in the internal nasal valve than that considered normal in the literature (10°-15°). We believe it is necessary to undertake a second study and add an airflow resistance measurement with a rhinomanometry procedure so we can compare the results with those in the Caucasian population.



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Airborne and food sensitization patterns in children and adults with eosinophilic esophagitis

Background

The pathogenesis of eosinophilic esophagitis (EoE) is currently unknown, but evidence suggests that allergic sensitization to food and airborne allergens may play a key role. This retrospective study examines the rate of sensitization to both food and airborne allergens in EoE patients, and compares their sensitivity patterns to control groups.

Methods

We identified 103 patients with a diagnosis of EoE via esophageal eosinophilia (≥15 eosinophils/high-power field [hpf]), who had undergone comprehensive food and/or airborne allergen testing through either skin or in vitro methods. Food and airborne allergen sensitization was defined as positive testing in at least 1 food subgroup (milk, peanut, tree nut, seafood/fish, soy, grain, egg) or airborne subgroup (tree, grass, weed, mite/cockroach, animal, mold), respectively. The same sensitization criterion was applied to allergic rhinitis (AR) patients, with and without a clinical suspicion of food allergy (FA), in order to create control groups.

Results

Sensitization in the EoE group to at least 1 subgroup of food allergen and airborne allergen was seen in 77.1% (64/83) and 71.7% (38/53), respectively (p = 0.82). There were significant differences in sensitization between EoE and control groups for tree nut, soy, grain, and egg, but no differences noted in any of the other food or airborne allergen subgroups, even after accounting for age and gender.

Conclusion

EoE and control groups had similar airborne allergen sensitization patterns, yet dissimilar food allergen sensitization patterns, suggesting that specific allergens may play a more prominent role in the pathogenesis of EoE. The EoE group had a more uniform distribution pattern for food allergens, compared to controls.



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Risk of second primary malignancy in patients with sinonasal tumors: a population-based cohort study

Background

The 5-year overall survival rate for patients with sinonasal cancers has remained around 50% for the last 3 decades. Prior studies on head and neck cancers have suggested that 1 reason for poor survival is the frequent development of second primary malignancies (SPMs). The purpose of this study is to assess overall and site-specific risks of SPM following treatment of sinonasal malignancy.

Methods

A retrospective, population-based cohort study was performed on 2614 patients in the Surveillance, Epidemiology, and End Results (SEER) database who were diagnosed with primary sinonasal malignancy between 1973 and 2014. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated to assess risk of SPM relative to incidence in the general population.

Results

A total of 422 (16.1%) patients with primary sinonasal malignancies developed a total of 480 SPMs. This cohort had a significantly higher frequency of SPMs than expected in the general population (SIR 1.32; 95% confidence interval [CI], 1.20 to 1.44; AER 53.41). Site-specific analyses of SIRs suggested highest risk of malignancy in the sinonasal tract (SIR 75.64; 95% CI, 53.53 to 103.83; AER 17.22), followed by bone, eye and orbit, oral cavity and pharynx, and lung and mediastinum.

Conclusion

Patients with history of sinonasal cancer are at significantly increased risk of developing an SPM. Careful monitoring for development of additional tumors may be warranted.



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How do dermarollers work?

Learn all about how to use dermarollers, and what effects they could have on the skin. We also look at things to consider when dermarolling.

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Johns Hopkins Expert Available to Discuss New AARP Nutrition and Brain Health Report

Today, the Global Council on Brain Health (GCBH), an independent collaborative of international scientists, health professionals, scholars and policy experts convened by AARP, published Brain Food

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Evaluation and Customization of WHO Safety Checklist for Patient Safety in Otorhinolaryngology

Abstract

The WHO has designed a safe surgery checklist to enhance communication and awareness of patient safety during surgery and to minimise complications. WHO recommends that the check-list be evaluated and customised by end users as a tool to promote safe surgery. The aim of present study was to evaluate the impact of WHO safety checklist on patient safety awareness in otorhinolaryngology and to customise it for the speciality. A prospective structured questionnaire based study was done in ENT operating room for duration of 1 month each for cases, before and after implementation of safe surgery checklist. The feedback from respondents (surgeons, nurses and anaesthetists) was used to arrive at a customised checklist for otolaryngology as per WHO guidelines. The checklist significantly improved team member's awareness of patient's identity (from 17 to 86%) and each other's identity and roles (from 46 to 94%) and improved team communication (from 73 to 92%) in operation theatre. There was a significant improvement in preoperative check of equipment and critical events were discussed more frequently. The checklist could be effectively customised to suit otolaryngology needs as per WHO guidelines. The modified checklist needs to be validated by otolaryngology associations. We conclude from our study that the WHO Surgical safety check-list has a favourable impact on patient safety awareness, team-work and communication of operating team and can be customised for otolaryngology setting.



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Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

Condition:   Oropharynx Cancer
Interventions:   Drug: Cetuximab;   Radiation: Radiation Therapy
Sponsors:   University of Michigan Cancer Center;   VA Ann Arbor Healthcare System
Not yet recruiting

http://ift.tt/2DNxFJV

An Observational Study to Evaluate Lymph Metastases and Prognoses of the Patients With Esophageal Cancer

Condition:   Esophageal Cancer
Intervention:   Procedure: Surgeries
Sponsors:   Henan Cancer Hospital;   LinkDoc Technology (Beijing) Co. Ltd.
Recruiting

http://ift.tt/2npvf9B

Explore the Efficiency of Fiberscope-guided Nasogastric Tube Insertion

Condition:   Nasogastric Tube Esophagitis
Intervention:   Device: Fiberscope-Guided Nasogastric tube insertion
Sponsor:   National Taiwan University Hospital
Recruiting

http://ift.tt/2DNxAWD

Adoptive Cell Therapy Following a Reduced Intensity, Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Ovarian

Condition:   Metastatic Ovarian Cancer
Interventions:   Drug: Fludarabine;   Radiation: Radiation;   Biological: TIL administration;   Drug: IL-2
Sponsor:   Sheba Medical Center
Not yet recruiting

http://ift.tt/2nrkDad

An 8-Year-Old Child with Delayed Diagnosis of Netherton Syndrome

We report an 8-year-old boy with Netherton syndrome who was misdiagnosed and treated as severe atopic dermatitis. The diagnosis of Netherton syndrome was not made until the child was 8 years of age. We discuss the pitfalls in the diagnosis and alert physicians to the proper and early diagnosis of this syndrome. The child was treated with a low dose (0.25 mg/kg) of oral acitretin and a topical moisturizer with marked improvement of his skin and pruritus in 2 months. At 6-month follow-up, the skin was almost clear of erythema and scaling, and the hair was longer and stronger. The dose of acitretin was reduced to 0.12 mg/kg for another 6 months and then discontinued.

http://ift.tt/2DPyv9n

Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature

Abstract

Background

Muckle-Wells syndrome (MWS) is a rare auto-inflammatory disease characterized by the presence of recurrent urticaria, deafness and amyloidosis. Progressive sensorineural hearing loss (SNHL) is reported to occur in up to 85% of patients occurring in the second and third decades and as early as the first decade in patients with a more severe phenotype, thus potentially having a significant impact on a child's development. IL-1 inhibitors, such as Anakinra, have been described to improve systemic inflammation, and stabilize or improve hearing status as well. However, complete resolution of hearing loss has been rarely reported. The objective of this article is to highlight the clinical presentation of a pediatric patient with a severe form of MWS and report on the complete resolution of SNHL with the use of Anakinra.

Case presentation

A 3-year-old boy was referred to our hospital to assess for the possibility of MWS given a history of hives and recurrent episodes of fever with a family history of MWS in his mother. Of note, the patient's history was significant for conductive hearing loss, speech delay, as well as recurrent acute otitis media episodes. Genetic analysis was performed and diagnosis of MWS was confirmed due to the presence of a NLRP3 gene mutation. Further work-up demonstrated the presence of papilledema and elevation of systemic inflammatory markers for which Canakinumab was initiated. Despite initiation of this treatment, audiogram evaluation demonstrated a new right-sided SNHL. Lumbar puncture also revealed aseptic meningitis. Canakinumab was eventually discontinued and Anakinra initiated. Within 7 months of treatment with Anakinra at 5 mg/kg sc daily, resolution of the SNHL was observed. With further escalation of the Anakinra dose, there was also complete resolution of the aseptic meningitis.

Conclusions

Progressive hearing loss is a significant finding in patients with MWS. Early screening as well as initiation of Anakinra can lead to complete resolution of SNHL even in a patient with a severe spectrum of MWS. However, as this case demonstrates, longer treatment duration and higher doses of Anakinra may be required to achieve this.



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Evolving concepts in dilated cardiomyopathy

Merlo, M; Cannatà, A; Gobbo, M; Stolfo, D; Elliott, PM; Sinagra, G; (2017) Evolving concepts in dilated cardiomyopathy. European Journal of Heart Failure 10.1002/ejhf.1103 . (In press).

http://ift.tt/2rUiYPE

Beyond feedback: introducing the ‘engagement gap’ in organizational energy management

Bull, R; Janda, KB; (2017) Beyond feedback: introducing the 'engagement gap' in organizational energy management. Building Research and Information 10.1080/09613218.2017.1366748 . (In press). Green open access

http://ift.tt/2GvoeN7

Utilitarian Placement of Composite Services

Phan, TK; Rocha, M; Griffin, D; Rio, M; (2018) Utilitarian Placement of Composite Services. IEEE Transactions on Network and Service Management 10.1109/TNSM.2018.2798413 . (In press). Green open access

http://ift.tt/2rUiDwm

An Ontology for Gendered Content Representation of Cultural Heritage Artefacts

Kyvernitou, I; Bikakis, A; (2017) An Ontology for Gendered Content Representation of Cultural Heritage Artefacts. Digital Humanities Quarterly , 11 (3) Green open access

http://ift.tt/2GwUxLo

Translating reality TV into Spanish: when fast-food TV challenges AVT conventions

Banos Pinero, R; (2018) Translating reality TV into Spanish: when fast-food TV challenges AVT conventions. Perspectives: Studies in Translation Theory and Practice 10.1080/0907676X.2018.1424221 . (In press).

http://ift.tt/2rUiqt4

Understanding perceived determinants of nurses’ eating and physical activity behaviour: a theory-informed qualitative interview study

Power, BT; Kiezebrink, K; Allan, JL; Campbell, MK; (2017) Understanding perceived determinants of nurses' eating and physical activity behaviour: a theory-informed qualitative interview study. BMC Obesity , 4 , Article 18. 10.1186/s40608-017-0154-4 . Green open access

http://ift.tt/2Gsn8BP

Crafting sustainability in iconic skyscrapers: a system of building professions in transition?

Janda, KB; (2017) Crafting sustainability in iconic skyscrapers: a system of building professions in transition? Nordic Journal of Science and Technology Studies , 5 (2) pp. 44-58. 10.5324/njsts.v5i2.2328 . Green open access

http://ift.tt/2rRzFeP

Protein-Rich or Amino-Acid Only Diets Entrain the Liver Clock: Time to Scrap Insulin? Andrea Maugeri, Jude A. Oben, Manlio Vinciguerra

Oben, J; (2018) Protein-Rich or Amino-Acid Only Diets Entrain the Liver Clock: Time to Scrap Insulin? Andrea Maugeri, Jude A. Oben, Manlio Vinciguerra. EBioMedicine 10.1016/j.ebiom.2018.01.020 . (In press).

http://ift.tt/2GwwOv2

Mid- to late-Holocene archaeology, environment and climate in the northeast Kurdistan region of Iraq

Marsh, A; Fleitmann, D; Al-Manmi, DAM; Altaweel, M; Wengrow, D; Carter, R; (2018) Mid- to late-Holocene archaeology, environment and climate in the northeast Kurdistan region of Iraq. The Holocene 10.1177/0959683617752843 . (In press). Green open access

http://ift.tt/2rRzrnZ

Multi-wavelength campaign on NGC 7469 II. Column densities and variability in the X-ray spectrum

Peretz, U; Behar, E; Kriss, GA; Kaastra, J; Arav, N; Bianchi, S; Branduardi-Raymont, G; ... Ursini, F; + view all Peretz, U; Behar, E; Kriss, GA; Kaastra, J; Arav, N; Bianchi, S; Branduardi-Raymont, G; Cappi, M; Costantini, E; De Marco, B; Di Gesu, L; Ebrero, J; Kaspi, S; Mehdipour, M; Middei, R; Paltani, S; Petrucci, PO; Ponti, G; Ursini, F; - view fewer (2018) Multi-wavelength campaign on NGC 7469 II. Column densities and variability in the X-ray spectrum. Astronomy & Astrophysics , 609 , Article A35. 10.1051/0004-6361/201731655 . Green open access

http://ift.tt/2GsmOTD

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Das, RK; Gale, G; Hennessy, V; Kamboj, SK; (2018) A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers. Journal of Visualized Experiments , 131 , Article e56097. 10.3791/56097 . Green open access

http://ift.tt/2rRQNB8

Bridging the Gap: the need for a systems thinking approach in understanding and addressing energy and environmental performance in buildings

Shrubsole, C; Hamilton, IG; Zimmermann, N; Papachristos, G; Broyd, T; Burman, E; Taylor, J; ... Davies, M; + view all Shrubsole, C; Hamilton, IG; Zimmermann, N; Papachristos, G; Broyd, T; Burman, E; Taylor, J; Mumovic, D; Zhu, Y; Lin, B; Davies, M; - view fewer (2018) Bridging the Gap: the need for a systems thinking approach in understanding and addressing energy and environmental performance in buildings. Indoor and Built Environment 10.1177/1420326X17753513 . (In press). Green open access

http://ift.tt/2rRzdNF

Bayesian inference for multiple Gaussian graphical models with application to metabolic association networks

Tan, LSL; Jasra, A; De Iorio, M; Ebbels, TMD; (2017) Bayesian inference for multiple Gaussian graphical models with application to metabolic association networks. The Annals of Applied Statistics , 11 (4) pp. 2222-2251. 10.1214/17-AOAS1076 . Green open access

http://ift.tt/2GvpeAH

Trial supports targeted radiotherapy for early breast cancer but protocol still requires 3 weeks of daily therapy

Vaidya, JS; Wenz, F; Tobias, JS; (2018) Trial supports targeted radiotherapy for early breast cancer but protocol still requires 3 weeks of daily therapy. Evidence Based Medicine , 23 (1) pp. 38-39. 10.1136/ebmed-2017-110849 . Green open access

http://ift.tt/2GsZXai

Efficacy and safety of cyclophosphamide treatment in severe juvenile dermatomyositis shown by marginal structural modelling

Deakin, CT; Campanilho-Marques, R; Simou, S; Moraitis, E; Wedderburn, LR; Pullenayegum, E; Pilkington, CA; Deakin, CT; Campanilho-Marques, R; Simou, S; Moraitis, E; Wedderburn, LR; Pullenayegum, E; Pilkington, CA; Juvenile Dermatomyositis Research Group (JDRG), ; - view fewer (2018) Efficacy and safety of cyclophosphamide treatment in severe juvenile dermatomyositis shown by marginal structural modelling. Arthritis Rheumatology 10.1002/art.40418 . (In press).

http://ift.tt/2rUsWRn

S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis

Gohar, F; Anink, J; Moncrieffe, H; Van Suijlekom-Smit, LWA; Prince, FHM; van Rossum, MAJ; Dolman, KM; ... Holzinger, D; + view all Gohar, F; Anink, J; Moncrieffe, H; Van Suijlekom-Smit, LWA; Prince, FHM; van Rossum, MAJ; Dolman, KM; Hoppenreijs, EPAH; Ten Cate, R; Ursu, S; Wedderburn, LR; Horneff, G; Frosch, M; Foell, D; Holzinger, D; - view fewer (2018) S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. The Journal of Rheumatology 10.3899/jrheum.170438 . (In press).

http://ift.tt/2Gwt4cL

The disparity between species description and conservation assessment: a case study in taxa with high rates of species discovery

Tapley, B; Michaels, CJ; Gumbs, R; Bohm, M; Luedtke, J; Pearce-Kelly, P; Rowley, JJL; (2018) The disparity between species description and conservation assessment: a case study in taxa with high rates of species discovery. Biological Conservation (In press).

http://ift.tt/2rUsVwN

A detailed X-ray investigation of zeta Puppis IV. Further characterization of the variability

Naze, Y; Ramiaramanantsoa, T; Stevens, IR; Howarth, ID; Moffat, AFJ; (2018) A detailed X-ray investigation of zeta Puppis IV. Further characterization of the variability. Astronomy & Astrophysics , 609 , Article A81. 10.1051/0004-6361/201730729 . Green open access

http://ift.tt/2Gy6GQA

Editorial: alfapump—an alternative to large-volume paracentesis for patients with refractory ascites?

Macdonald, S; Jalan, R; (2018) Editorial: alfapump—an alternative to large-volume paracentesis for patients with refractory ascites? [Editorial comment]. Alimentary Pharmacology and Therapeutics , 47 (1) pp. 139-140. 10.1111/apt.14390 .

http://ift.tt/2rRzbp1

Efficient multi-task allocation and path planning for unmanned surface vehicle in support of ocean operations

Liu, Y; Bucknall, R; (2017) Efficient multi-task allocation and path planning for unmanned surface vehicle in support of ocean operations. Neurocomputing , 275 pp. 1550-1566. 10.1016/j.neucom.2017.09.088 .

http://ift.tt/2GxOCG3

Evaluation and Customization of WHO Safety Checklist for Patient Safety in Otorhinolaryngology

Abstract

The WHO has designed a safe surgery checklist to enhance communication and awareness of patient safety during surgery and to minimise complications. WHO recommends that the check-list be evaluated and customised by end users as a tool to promote safe surgery. The aim of present study was to evaluate the impact of WHO safety checklist on patient safety awareness in otorhinolaryngology and to customise it for the speciality. A prospective structured questionnaire based study was done in ENT operating room for duration of 1 month each for cases, before and after implementation of safe surgery checklist. The feedback from respondents (surgeons, nurses and anaesthetists) was used to arrive at a customised checklist for otolaryngology as per WHO guidelines. The checklist significantly improved team member's awareness of patient's identity (from 17 to 86%) and each other's identity and roles (from 46 to 94%) and improved team communication (from 73 to 92%) in operation theatre. There was a significant improvement in preoperative check of equipment and critical events were discussed more frequently. The checklist could be effectively customised to suit otolaryngology needs as per WHO guidelines. The modified checklist needs to be validated by otolaryngology associations. We conclude from our study that the WHO Surgical safety check-list has a favourable impact on patient safety awareness, team-work and communication of operating team and can be customised for otolaryngology setting.



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16S rRNA profiling of the Dermatophagoides farinae core microbiome: Enterococcus and Bartonella

Abstract

Characterization of the house dust mite (HDM; Dermatophagoides farinae) microbiome is important because it may exert immunomodulatory effects on the pathogenesis of allergic diseases, owing to its ability to generate microbe-associated molecules such as lipopolysaccharides and lipoteichoic acid.[1] In a recent study, whole-genome shotgun sequencing of D. farinae revealed that Enterobacter were the most abundant bacteria[2], while another study using 16S rRNA cloning reported that Bartonella was the most abundant bacterial taxon.[3] In this study, a 16S rRNA amplicon analysis using high-throughput sequencing technology was performed; this is currently the most widely used and reliable method for microbiome community studies.

This article is protected by copyright. All rights reserved.



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A Case of First Branchial Cleft Fistula Presenting with an External Opening on the Root of the Helical Crus

Background. First branchial cleft anomalies (FBCA) are rare clinical entities of the head and neck. Typically, the tract of the FBCA begins in the external auditory canal and ends in the postauricular or submandibular region. Case Presentation. We present a case of a 23-year-old man who had a first branchial cleft fistula with atypical opening on the root of the helical crus. Complete excision of the tract, including the cuff of surrounding cartilage, was performed. Histopathology revealed a fistular tract lined with squamous epithelium. To our knowledge, this is the first case to be reported of type I FBCA with an opening on the root of the helical crus. The low incidence and varied presentation often result in misdiagnosis and inappropriate treatment. Conclusions. In the patients with FBCA, careful recognition of atypical variants is essential for complete excision.

http://ift.tt/2EmG4B6

Asthma and IgE associated polymorphisms affect expression of TH17 genes

Abstract

TH17 cells contribute to the pathogenesis of chronic inflammatory diseases such as asthma and TH17 pathway tagging SNPs were associated with asthma and total serum IgE levels in childhood. In this study genotype-specific effects of these SNPs on the expression of TH17 related molecules were analyzed in peripheral blood mononuclear cells (PBMCs) before and after allergen stimulation in 61 individuals. After correction for multiple testing, protein or mRNA expression levels of several molecules, including IL-17A, IL17-F, IL-23 and IL-23 receptor, were significantly correlated with asthma-associated SNPs (located in IL17F, IL22, IL23R and IL23A) and IgE-associated polymorphisms (located in IL17A and three SNPs in IL12B). Most extensive effects on TH17 pathway expression were observed for the asthma-associated polymorphism IL17F rs7741835. In conclusion, genetic variants in IL17F and, to a smaller degree, IL17A and IL-23 signaling genes associated with asthma and IgE levels seem functional in influencing expression of TH17 related molecules, indicating a contribution of these mechanisms to genetic susceptibility towards asthma and atopy.

This article is protected by copyright. All rights reserved.



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IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis

Abstract

Despite the critical role of soluble IgE in the pathology of IgE-mediated allergic disease, little is known about abnormalities in the memory B-cells and plasma cells that produce IgE in allergic patients. We here applied a flowcytometric approach to cross-sectionally study blood IgE+ memory B-cells and plasmablasts in 149 children with atopic dermatitis, food allergy and/or asthma, and correlated these to helper-T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+CD27- and IgE+CD27+ memory B-cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells. IgE+ plasmablast numbers correlated positively with Th2 cell numbers. These findings open new possibilities for diagnosis and monitoring of treatment in patients with allergic diseases.

This article is protected by copyright. All rights reserved.



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A retrospective case control analysis of the efficacy of Gardasil® vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx

Abstract

Recurrent respiratory papillomatosis (RRP) of the larynx represents a significant disease burden to patients and the healthcare system

The use of HPV 6/11/16/18 vaccination (Gardasil®) has previously been thought to impact on disease burden in patients with RRP.

Gardasil® vaccination did not impact on the number of endolaryngeal surgical procedures required, the interval between procedures, or the number of patients who achieved disease remission in comparison to a control cohort.

This study indicates Gardasil® vaccination does not appear to have any effect on disease burden in patients with RRP.

The use of a control cohort profiles the natural progression of RRP.

This article is protected by copyright. All rights reserved.



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Deprivation in relation to urgent suspicion of head and neck cancer referrals in Glasgow

Abstract

Aim

To examine deprivation measured by the Scottish Index of Multiple Deprivation (SIMD) and its relation to urgent suspicion of head and neck cancer referrals. A secondary aim was to examine the symptomatology generating urgent suspicion of cancer (USOC) referrals by SIMD category.

Methods

All "Urgent Suspicion of Cancer" referrals to the GGC ENT department over a one-year period, between 2015-16, were reviewed. Information was recorded anonymously and included demographics and red flag referral symptoms.

Results: 1998 patients were assessed, 43.4% (n=867) were male. 171 (8.6%) patients had primary head and neck cancer. 61 patients had other types of cancer, giving an all cause cancer rate of 11.6%. 71.3% of primary HNC patients were male. The most common SIMD category observed was SIMD1, the most common SIMD category yielding a primary head and neck cancer diagnosis was SIMD1. Neck lump was the commonest symptom amongst all SIMD categories.

Conclusion

A link between deprivation and USOC referrals has been established. A difference in gender distribution between referrals and HNC was observed, more females are referred but a significantly higher number of HNC patients are males. Neck lump is a very strong referral indicator for HNC and intermittent hoarseness is not. The findings from this analysis could be used to refine local referral patterns and priority of referral.

This article is protected by copyright. All rights reserved.



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e-Inhalers



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Forthcoming Meetings



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Issue Information



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Cover Image

Thumbnail image of graphical abstract

The cover image, by Carina Venter et al., is based on the Invited Review A patient-specific approach to develop an exclusion diet to manage food allergy in infants and children, DOI: 10.1111/cea.13087.



http://ift.tt/2DRd5IA

The Mindedness of Maternal Touch: An Investigation of Maternal Mind-Mindedness and Mother-Infant Touch Interactions

Crucianelli, L; Wheatley, L; Filippetti, ML; Jenkinson, P; Kirk, E; Fotopoulou, A; (2018) The Mindedness of Maternal Touch: An Investigation of Maternal Mind-Mindedness and Mother-Infant Touch Interactions. Developmental Cognitive Neuroscience (In press). Green open access

http://ift.tt/2GtLBGK

From dBase III+ to the semantic web: twenty-five years of the Coin Hoards of the Roman Republic database

Gruber, Ethan; Lockyear, Kris; (2015) From dBase III+ to the semantic web: twenty-five years of the Coin Hoards of the Roman Republic database. In: Traviglia, A, (ed.) Across Time and Space: Papers from the 41st Conference on Computer Applications and Quantitative Methods in Archaeology, Perth, 25--28th March 2013. (pp. 336-346). Amsterdam University Press: Amsterdam, Netherlands. Green open access

http://ift.tt/2rU3Z8F

Altruïsme en ongelijkheidsaversie in intra- en intergroupinteracties

Aksoy, Ozan; Weesie, Jeroen; (2012) Altruïsme en ongelijkheidsaversie in intra- en intergroupinteracties. In: Buskens, V and Maas, I, (eds.) Onderzoek naar sociale dilemma's in Nederland. Amsterdam University Press: Amsterdam, Netherlands. Green open access

http://ift.tt/2Gx7uVQ

Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences

Jones, HJ; Gage, SH; Heron, J; Hickman, M; Lewis, G; Munafò, MR; Zammit, S; (2018) Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences. JAMA Psychiatry 10.1001/jamapsychiatry.2017.4271 . (In press).

http://ift.tt/2rU3Py5

T cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents Haemophagocytic Lymphohistiocytosis manifestations

Ghosh, S; Carmo, M; Calero-Garcia, M; Ricciardelli, I; Bustamante Ogando, JC; Blundell, MP; Schambach, A; ... Gaspar, HB; + view all Ghosh, S; Carmo, M; Calero-Garcia, M; Ricciardelli, I; Bustamante Ogando, JC; Blundell, MP; Schambach, A; Ashton-Rickardt, PG; Booth, C; Ehl, S; Lehmberg, K; Thrasher, AJ; Gaspar, HB; - view fewer (2018) T cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents Haemophagocytic Lymphohistiocytosis manifestations. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2017.11.050 . (In press).

http://ift.tt/2GtLhrw

Cardiometabolic health among adult offspring of hypertensive pregnancies: The cardiovascular risk in young finns study

Tapp, RJ; Hughes, AD; Kähönen, M; Wong, TY; Witt, N; Lehtimäki, T; Hutri-Kähönen, N; ... Raitakari, OT; + view all Tapp, RJ; Hughes, AD; Kähönen, M; Wong, TY; Witt, N; Lehtimäki, T; Hutri-Kähönen, N; Sahota, P; Juonala, M; Raitakari, OT; - view fewer (2018) Cardiometabolic health among adult offspring of hypertensive pregnancies: The cardiovascular risk in young finns study. Journal of the American Heart Association , 7 , Article e006284. 10.1161/JAHA.117.006284 .

http://ift.tt/2rQf76n

Test Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study

Palmer, CE; Langbehn, D; Tabrizi, SJ; Papoutsi, M; (2018) Test Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study. Frontiers in Psychology , 8 (2363) 10.3389/fpsyg.2017.02363 . Green open access

http://ift.tt/2Gwt3pc

Information-aware access network selection

Katsaros, KV; Shtefan, D; Sourlas, V; Psaras, I; Rene, S; Pavlou, G; (2017) Information-aware access network selection. In: (Proceedings) IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS). (pp. pp. 181-186). IEEE Green open access

http://ift.tt/2rU3A69

Eostre the goddess and the free-standing posts of Yeavering

North, John R; (2017) Eostre the goddess and the free-standing posts of Yeavering. In: Lacey, ME, (ed.) Starcraeft: watching the heavens in the Middle Ages. Amsterdam University Press: Amsterdam, Netherlands.

http://ift.tt/2GtKYwS

Flat-topped papules on the face of a young boy



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Extranodal natural killer/T-cell lymphoma, nasal type, in Senegal

Abstract

Introduction

The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal.

Methodology

A 5-year retrospective review of all patients with histopathological, immunohistochemical, and in situ hybridization proven cutaneous lymphomas

Results

We collected seven cases corresponding to a frequency of 1.4 cases per year. ENKTCL accounted for 10.5% of all cutaneous lymphomas, ranking second after T-cell lymphomas. Men were predominantly affected (M : F ratio of 6), and the mean age was 38.5 years ± 4.06. The mean time before consultation was 7.3 months. The lymphomas affected primarily the nasal cavity in five cases and the skin in two cases. At admission, six patients had nasal mucosa involvement, which was isolated in three cases, associated with cutaneous lesions in three cases and lymph node involvement in three cases. CD56 was positive in only one case, and Eber transcribed RNA of EBV was expressed by in situ hybridization in all patients.

Discussion

To our knowledge, we have reported the first and largest series of ENKTCL in Sub-Saharan Africa. Our study shows an intermediate prevalence between that reported from Asia, Latin America, and the West. It was also noted a young age of patients, a prolonged diagnostic delay, a frequent negativity of CD56 marker, and a very poor prognosis of the disease in our region.



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The treatment outcomes and dose de-escalation of desloratadine up-dosing in chronic spontaneous urticaria

Abstract

Background

An increase in dosages up to fourfold of second generation antihistamines is recommended for recalcitrant chronic spontaneous urticaria (CSU). No regimen guidelines about dose de-escalation, however, are mentioned once the disease is controlled.

Objective

To demonstrate the treatment outcomes and dose reduction in desloratadine assessed using the urticarial activity score over 7 consecutive days.

Methods

Medical records of all patients with CSU treated with desloratadine were collected retrospectively during a period from January 2010 to December 2013.

Results

Sixty-seven (94.4%) patients had remission of the disease with variable doses of desloratadine. The patients who had CSU concomitant with antithyroid antibodies or high erythrocyte sedimentation rates had a greater tendency not to respond to the standard dose. Once the disease was completely controlled, 67 patients finished the treatment, but 63 (94%) patients had recurrent symptoms. Sixty-three patients took the same dose that induced the response for a further 4 weeks before stopping or reducing the dose, 41/63 (65.1%), however developed urticaria again. Forty-one patients took the same dose for a further 8 weeks; only 2/41 (4.9%) patients developed the rash again. The mean follow-up period after the disease was controlled was 7.5 months.

Conclusion

Most patients need higher than the standard doses to obtain remission. Once the disease is completely controlled, however, maintenance of the same dosage for at least 8 weeks before dose reduction is suggested in order to avoid recurrence of the symptoms.



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Glycyl tRNA Synthetase (GARS) Gene Variant Causes Distal Hereditary Motor Neuropathy V

Distal hereditary motor neuropathies (dHMN) are a rare heterogeneous group of inherited disorders specifically affecting the motor axons, leading to distal limb neurogenic muscular atrophy. The GARS gene has been identified as a causative gene responsible for clinical features of dHMN type V in families from different ethnic origins and backgrounds. We present the first cohort of family members of Nigerian descent with a novel heterozygous p.L272R variant on the GARS gene. We postulate that this variant is the cause of dHMN-V in this family, leading to variable phenotypical expressions that are earlier than reported in previous cases. The exact cause for the observed clinical heterogeneity within the family is unknown. One explanation is that there are modifier genes that affect the phenotype. These cases highlight the possibility of considering pathogenic variants in the GARS gene as a potential cause of early onset axonal polyneuropathy with atypical presentation.

http://ift.tt/2BEOGQE

Management of comedonal acne vulgaris with fixed-combination topical therapy

Summary

Background

Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Clinically, it is characterized by a combination of open and closed comedones (formally referred to as noninflammatory lesions) and inflammatory papules and pustules. Comedonal acne is more typical in young adolescents, but can occur in combination with inflammatory papules and pustules at any time. Topical retinoids have long been advocated for the treatment of comedonal acne.

Aims

Given the increasing recognition of the inflammatory nature of acne and the synergistic benefits seen with fixed combinations we review the latest clinical data to provide guidance on optimal management of comedonal acne.

Methods

An English language literature search of Medline, EMBASE, and the Web of Science using key terms (acne, comedonal, noninflammatory, clinical trials) was conducted, and relevant articles reviewed.

Results

Comparative data is sparse, but we show the importance of fixed combinations with and without retinoids, where treatment benefits are comparable. Adapalene 0.1%-benzoyl peroxide 2.5% gel has been shown to be comparable to clindamycin 1%-benzoyl peroxide 5% gel, and adapalene 0.3%-benzoyl peroxide 2.5% gel. A meta-analysis suggested that clindamycin 1.2%-benzoyl peroxide 2.5% gel was more effective than clindamycin-benzoyl peroxide 5% gel in noninflammatory lesions, and two equivalent clinical programs suggest additional benefits of higher doses of benzoyl peroxide (3.75% vs 2.5%) in this fixed combination.

Conclusions

Clindamycin 1.2%-benzoyl peroxide 3.75% gel may afford similar benefits to adapalene 0.3%-benzoyl peroxide 2.5% gel in this sometimes difficult to treat patient population.



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Conservation Status of the Family Orchidaceae in Spain Based on European, National, and Regional Catalogues of Protected Species

This report reviews the European, National, and Regional catalogues of protected species, focusing specifically on the Orchidaceae family to determine which species seem to be well-protected and where they are protected. Moreover, this examination highlights which species appear to be underprotected and therefore need to be included in some catalogues of protection or be catalogued under some category of protection. The national and regional catalogues that should be implemented are shown, as well as what species should be included within them. This report should be a helpful guideline for environmental policies about orchid's conservation in Spain, at least at the regional and national level. Around 76% of the Spanish orchid flora are listed with any figure of protection or included in any red list, either nationally (about 12–17%) or regionally (72%).

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Does cochlear implant brand influence patient satisfaction? A survey of 102 cochlear implant users

Abstract

Patients and parents in particular can find the decision regarding which device to have implanted difficult due to the amount of often complicated information that is available. The desire to choose the 'right' implant for themselves or their child takes on great importance due to the finality of the procedure.

There is some evidence that certain patient expectations may be linked to brand choice and marketing strategies.

This study showed that importance of language development was strongly linked with a MED-EL device, and speech improvement with Advanced Bionics.

Despite marketing strategies put forth by the three major cochlear implant companies claiming superiority over each other, there seems to be an equal level of patient satisfaction regardless of the device implanted.

The results of this study can also be seen as good news for industry in that all three brands seem to be at least equivalent in their desired outcomes; however, these results may also be seen as a potential catalyst for a change in marketing strategy.

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Initial validation of the Burden of Disease in Atopic Eczema instrument, a quality of life measure for adult atopic dermatitis

Abstract

The Harmonizing Outcome Measures for Eczema (HOME) initiative identified quality of life (QoL) as a core outcome domain that should be assessed in all atopic dermatitis (AD) trials.1 However, based on a systematic review of the measurement properties of QoL instruments, HOME could not reach consensus on which QoL instrument should be recommended for adult AD.2,3 In response to the need for a valid QoL instrument, we developed the Burden of Disease in Atopic Eczema (BODE) instrument.

This article is protected by copyright. All rights reserved.



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Issue Information



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Clinical Snippets



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Patients with psoriasis are frequently using sunbeds



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EAACI Guidelines on Allergen Immunotherapy: Executive Statement

Abstract

The allergist's community has recently celebrated 100 year of Allergen Immunotherapy (AIT). Unfortunately the implemention of this treatment is still impaired by some challenges. With the diversity of definitions, methodology and different allergen products used, research studies have produced conflicting outcomes. This has resulted in confusion about the benefits and risks of AIT amongst policymakers and professionals, as well as in the variable availability of AIT products, regulation and reimbursement policies globally. In 2015 EAACI initiated the AIT Guidelines project as part of the Presidential plan in order to settle the controversies.

This article is protected by copyright. All rights reserved.



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Prediction of the severity of allergic reactions to foods

Abstract

Background

There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted.

Objective

To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact.

Methods

The study population consisted of children with a double-blind, placebo-controlled food challenge (DBPCFC) confirmed food allergy to milk, egg, peanut, cashew nut and/or hazelnut. The data was analyzed using multiple linear regression analysis. Missing values were imputed using multiple imputation techniques. Two scoring systems were used to determine the severity of the reactions.

Results

734 children were included. Independent predictors for the severity of the DBPCFC reaction were: age (B=0.04, p=0.001), skin prick test ratio (B=0.30, p<0.001), eliciting dose (B=-0.09, p<0.001), level of specific immunoglobulin E (B=0.15, p<0.001), reaction time during the DBPCFC (B=-0.01, p=0.004), and severity of accidental reaction (B=0.08, p=0.015). The total explained variance of this model was 23.5%, and the eliciting dose only contributed 4.4% to the model. Independent predictors for more severe accidental reactions with an explained variance of 7.3% were: age (B=0.03, p=0.014), milk as causative food (B=0.77, p<0.001), cashew as causative food (B=0.54, p<0.001), history of atopic dermatitis (B=-0.47, p=0.006), and severity of DBPCFC reaction (B=0.12, p=0.003).

Conclusions

The severity of DBPCFCs and accidental reactions to food remain largely unpredictable. Clinicians should not use the eliciting dose obtained from a graded food challenge for the purposes of making risk-related management decisions.

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ESTEEM - a new ‘hybrid complexity’ model for simulating estuary morphological evoluation at decadal to centennial scales

Thornhill, G; French, J; Burningham, H; (2015) ESTEEM - a new 'hybrid complexity' model for simulating estuary morphological evoluation at decadal to centennial scales. In: (Proceedings) Coastal Sediments.

http://ift.tt/2BCRJJ8

Wave-driven sediment pathways on the gravel-dominated Suffolk coast, eastern UK

French, J; Burningham, H; (2015) Wave-driven sediment pathways on the gravel-dominated Suffolk coast, eastern UK. In: The Proceedings of the Coastal Sediments 2015. World Scientific: San Diego, USA.

http://ift.tt/2nlf1iu

Thermal responses of single zone offices on existing near-extreme summer weather data

Ji, Y; Korolija, I; Zhang, Y; (2018) Thermal responses of single zone offices on existing near-extreme summer weather data. Building Simulation , 11 (1) pp. 15-35. 10.1007/s12273-017-0367-y .

http://ift.tt/2BCnFgT

Frail older people with multi-morbidities in primary care: a new integrated care clinical pharmacy service

Oboh, L; Leon, C; Qadir, S; Smith, F; Francis, S-A; (2017) Frail older people with multi-morbidities in primary care: a new integrated care clinical pharmacy service. International Journal of Clinical Pharmacy 10.1007/s11096-017-0566-8 . (In press).

http://ift.tt/2nl2HP0

Sparse Causality Network Retrieval from Short Time Series

Aste, T; Di Matteo, T; (2017) Sparse Causality Network Retrieval from Short Time Series. Complexity , 2017 , Article 4518429. 10.1155/2017/4518429 . Green open access

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Interactions with television companion apps: four findings and a model

Dowell, J; Kim, H; (2015) Interactions with television companion apps: four findings and a model. In: Proceedings of the Human Factors and Ergonomics Society 59th Annual Meeting - 2015. (pp. pp. 155-159). Sage: London, United Kingdom.

http://ift.tt/2nlEOXH

Using a professional life history approach to support identification and identity transformation for neophyte teachers and teacher educators as they transition into new professional roles

Amott, PM; (2015) Using a professional life history approach to support identification and identity transformation for neophyte teachers and teacher educators as they transition into new professional roles. In: Proceedings of Teacher Education Advancement Network (TEAN) Conference 2015. University of Cumbria: Cumbria, United Kingdom. (In press).

http://ift.tt/2BDxifl

Good criminal laws and how to draft them

Xanthaki, Helen; (2017) Good criminal laws and how to draft them. In: Spinellis, CD and Theodorakis, N and Billis, E and Papadimitrakopoulos, G, (eds.) Europe in Crisis: Crime, Criminal Justice, and the Way Forward. (pp. 273-287). Ant. Sakkoulas: Athens, Greece.

http://ift.tt/2nlsfvy

Estimating tourism statistics with Wikipedia page views

Alis, C; Letchford, A; Moat, HS; Preis, T; (2015) Estimating tourism statistics with Wikipedia page views. In: WebSci '15 Proceedings of the ACM Web Science Conference Article No. 33. ACM: Oxford, United Kingdom. Green open access

http://ift.tt/2BEompJ

Setting the Scene: Meeting Inputs, Objectives, Structure and Expected Outcomes

Zhang, L-Y; (2015) Setting the Scene: Meeting Inputs, Objectives, Structure and Expected Outcomes. Presented at: Expert meeting on livelihoods and economic diversification, Bonn, Germany. Green open access

http://ift.tt/2nnnnGc

Adsorptive Removal of Congo Red Dye using Surfactant Modified Carbon-doped TiO2

Chaudhari, V; Mayadevi, S; Kim, JK; Campos, LC; Ciric, L; Goswami, AK; Sonar, SK; (2015) Adsorptive Removal of Congo Red Dye using Surfactant Modified Carbon-doped TiO2. In: Proceedings of International Conference on Green and Sustainable Chemistry 2015. GSC8 Symposium Secretariat: Melbourne, Australia. (In press).

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Speak to the Leg: A Post-Paralympic Analysis and Retheorization of Consumer-object Relations

Duus, R; Davies, A; Saren, M; (2014) Speak to the Leg: A Post-Paralympic Analysis and Retheorization of Consumer-object Relations. In: Bradshaw, A and Rappel, A, (eds.) Macromarketing and the Crisis of the Social Imagination: Proceedings of the 39th Annual Macromarketing Conference, 2014. (pp. pp. 480-484). Macromarketing Society Green open access

http://ift.tt/2DMS9OW

Assessment of the Effectiveness of Nutributter® Distribution on Anaemia and Stunting in Refugee Populations in Djibouti and Kenya

Style, S; Tondeur, M; Grijalva-Eternod, C; Pringle, J; Wilknson, C; Kassim, I; Oman, A; ... Seal, AJ; + view all Style, S; Tondeur, M; Grijalva-Eternod, C; Pringle, J; Wilknson, C; Kassim, I; Oman, A; Dolan, C; Seal, AJ; - view fewer (2015) Assessment of the Effectiveness of Nutributter® Distribution on Anaemia and Stunting in Refugee Populations in Djibouti and Kenya. Presented at: The Micronutrient Forum Global Conference – Bridging Discovery and Delivery, Addis Ababa. Green open access

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Mild phenotype of junctional epidermolysis bullosa with pyloric atresia due to a novel mutation of the ITGB4 gene



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Case of bullous pemphigoid associated with teneligliptin accompanied by severe mucous membrane involvement



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Acne and hidradenitis suppurativa

Summary

Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily defined by the presence of comedones and inflammatory lesions. However, in HS the intertriginous localization and chronicity play equally important roles for the diagnosis to the inflammatory lesions. Genetics, bacteria, environmental factors and innate inflammation have all been found to play a role in acne and/or HS. Surprisingly, there is little overlap between the findings so far. The genetics of acne and HS are distinct, bacteria have not been shown convincingly to play a role in HS, and the important risk factors obesity and smoking in HS cannot be easily translated to acne. The one driving factor central to both diseases is innate inflammation, most strikingly involving interleukin-1. Hence the interleukin-1 family, as already shown in autoinflammatory conditions associated with acne, could represent attractive treatment targets.



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Retrospective study: Rapamycin or rapalog 0.1% cream for facial angiofibromas in Tuberous Sclerosis Complex: Evaluation of treatment effectiveness and cost

Abstract

The use of topical rapamycin or rapalog, an mTOR inhibitor, has shown promising results in treating facial angiofibromas (FA) in children with Tuberous Sclerosis Complex (TSC). Nevertheless, several issues remain: the effectiveness, stability and tolerability of ingredients; and the cost - the higher the concentration of rapamycin the more expensive the product. In this retrospective comparative study, children with TSC and FA were treated consecutively with three different topical rapalog compounds of 0.1%, the lowest concentration with crushed tablets to demonstrate an effect.

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