Association between hidradenitis suppurativa and hospitalization for psychiatric disorders: A cross‐sectional analysis of the National Inpatient Sample

Abstract

Background

Hidradenitis suppurativa (HS) is associated with pain, disfigurement, psychosocial distress and poor quality of life, all of which may lead to higher likelihood of mental health (MH) disorders. However, little is known about the MH comorbidities of HS.

Objectives

to determine the MH disorders and cost‐burden associated with HS.

Methods

Data were examined from the 2002‐2012 National Inpatient Sample, comprising a ~20% sample of all US pediatric and adult hospitalizations (n=87,053,155 admissions).

Results

MH disorders were much more common in inpatients with vs. without HS (34·27% vs. 20·05%). In multivariable logistic regression models controlling for gender, age, race/ethnicity, and insurance status, HS was associated with significantly higher odds of a MH disorder (adjusted odds ratio [95% confidence interval]: 2·53 [2·42‐2·63]), including 10 of 15 MH disorders examined. In contrast, HS was not associated with primary hospitalization for a MH disorder overall (0·95 [0·84‐1·07]), but was associated with primary hospitalization for 8 of 15 MH disorders examined. Among inpatients with HS, primary admission for a MH disorder was associated with female sex, public or no insurance, more chronic diseases, but inversely associated with older age, female sex, and non‐white race/ethnicity. HS was associated with >$38 million of excess mean annual costs of hospitalization for MH disorders.

Conclusions

Inpatients with HS had increased odds of comorbid mental health disorders, overall, and multiple primary mental health admissions, in particular, which were associated with considerable excess costs.

This article is protected by copyright. All rights reserved.

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Interaction of the mycotoxin metabolite dihydrocitrinone with serum albumin

Abstract

Citrinin (CIT) is a nephrotoxic mycotoxin produced by Penicillium, Monascus, and Aspergillus species. CIT appears as a contaminant in cereals, cereal-based products, fruits, nuts, and spices. During the biotransformation of CIT, its major urinary metabolite dihydrocitrinone (DHC) is formed. Albumin interacts with several compounds (including mycotoxins) affecting their tissue distribution and elimination. CIT-albumin interaction is known; however, the complex formation of DHC with albumin has not been reported previously. In this study, we aimed to investigate the interaction of DHC with albumin, employing fluorescence spectroscopy, circular dichroism, and molecular modeling studies. Furthermore, species differences and thermodynamics of the interaction as well as the effects of albumin on the acute in vitro toxicity of DHC and CIT were also tested. Our main observations/conclusions are as follows: (1) Fluorescence signal of DHC is strongly enhanced by albumin. (2) Formation of DHC-albumin complexes is supported by both fluorescence spectroscopic and circular dichroism studies. (3) DHC forms similarly stable complexes with human albumin (K~10⁵ L/mol) as CIT. (4) DHC-albumin interaction did not show significant species differences (tested with human, bovine, porcine, and rat albumins). (5) Based on modeling studies and investigations with site markers, DHC occupies the Heme binding site (subdomain IB) on human albumin. (6) The presence of albumin significantly decreased the acute in vitro cytotoxic effects of both DHC and CIT on MDCK cell line.

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Thyroid® High-Impact Articles

FREE ACCESS through November 27, 2018.
Latest Impact Factor: 7.557
The Official Journal of: American Thyroid Association^®

Read now:

Immune-Related Thyroiditis with Immune Checkpoint Inhibitors
Priyanka C. Iyer, Maria E. Cabanillas, Steven G. Waguespack, Mimi I. Hu, Sonali Thosani, Victor R. Lavis, Naifa L. Busaidy, Sumit K. Subudhi, Adi Diab, and Ramona Dadu

Patients with Benign Thyroid Diseases Experience an Impaired Sex Life
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Laszlo Hegedüs, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, and Torquil Watt

Thyroid Cancer Treatment Choice: A Pilot Study of a Tool to Facilitate Conversations with Patients with Papillary Microcarcinomas Considering Treatment Options
Juan P. Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Goon Kim, Nicole M. Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-hoon Kim, Ian Hargraves, Victor Bernet, Victor M. Montori, Young Joo Park, and R. Michael Tuttle

Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care
Tim I.M. Korevaar, Lidia Mínguez-Alarcón, Carmen Messerlian, Ralph A. de Poortere, Paige L. Williams, Maarten A. Broeren, Russ Hauser, and Irene C. Souter  

Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, and Jukka Kero  

The post <i>Thyroid^®</i> High-Impact Articles appeared first on American Thyroid Association.

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Long‐term quality of life in older patients with HPV‐related oropharyngeal cancer

Abstract

Background

We explored if age affects quality of life (QOL) in survivors of locally advanced human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC).

Methods

In a cross‐sectional survey of 185 patients, at least 12 months from radiation, we evaluated generic (EuroQOL‐5D questionnaire [EQ‐5D]) and head and neck specific (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Head and Neck 35‐questions [EORTC‐QLQ‐H&N35]) QOL questionnaires and compared differences between younger (<65) and older (≥65) patients.

Results

The median age was 57.0 years (range 25‐77 years), and 31 patients (16.8%) were ≥65 years old. There was no significant difference in EQ‐5D global QOL scores by age (P = .53). Patients ≥65 years reported more immobility (P < .01), problems with social eating (P < .0001), and coughing (P < .01). Patients ≥65 years were not more likely to ever require a gastrostomy (P = .24) but were more likely to remain gastrostomy‐dependent at the time of the survey (P = .02).

Conclusion

Despite similar generic QOL, older survivors may have more mobility problems and issues with social eating compared with younger survivors deserving of further evaluation.

https://ift.tt/2zOGhv1

Patterns of failure after postoperative intensity‐modulated radiotherapy for locally advanced buccal cancer: Initial masticator space involvement is the key factor of recurrence

Abstract

Background

The purpose of this study was to determine failure patterns and clinicopathologic prognostic factors in patients with locally advanced buccal cancer after postoperative intensity‐modulated radiotherapy (IMRT).

Methods

Eighty‐two patients with locally advanced (American Joint Committee on Cancer [AJCC] stage III/IV) buccal cancer who underwent surgery followed by postoperative IMRT between January 2007 and October 2012 were retrospectively analyzed.

Results

Eighteen patients had local recurrences as the first recurrent site and 11 had supramandibular notch recurrences; the majority of recurrences were classified as marginal failures. The median time from the first local or regional recurrence to death was 5.9 months. In multivariate analyses of survivals, the initial masticator space involvement was the most important prognostic factor. Masticator space involvement, N classification, and maxillectomy were the significant prognostic predictors for supramandibular notch recurrences.

Conclusion

Postoperative IMRT for buccal cancer should not include the surgical beds alone, rather, it should be based on the potential patterns of spread.

https://ift.tt/2Tc2Ti4

Pattern of planned systemic therapy usage in newly diagnosed, nonmetastatic squamous cell carcinoma of the head and neck in a commercially insured population in the United States

Abstract

Background

We analyzed systemic therapy plans submitted for commercially insured patients with untreated, newly diagnosed squamous cell carcinoma of the head and neck (SCCHN) to investigate patterns of practice.

Methods

Consecutive chemotherapy treatment plans were submitted using Eviti Connect (https://www.marylandphysicianscare.com/content/dam/centene/maryland/pdfs/evitiConnectFactSheet.pdf) portal for preauthorization between June 1, 2011, and June 30, 2015, were analyzed.

Results

A total of 387 treatment plans were submitted for 340 patients; 68 and 272 patients were from academic centers and community practices, respectively. Single agent cisplatin (57%), cetuximab (18%), and carboplatin (9%) were the most commonly proposed regimens concurrent with definitive radiotherapy (RT). The frequency of cetuximab use was not significantly different between academic centers and community practices. A clinical trial was proposed in only 15% of patients.

Conclusion

Among commercially insured patients with newly diagnosed, nonmetastatic SCCHN, the choice of systemic therapy in initial treatment plans was not significantly different between academic centers and community practices. Clinical trials are underutilized and should be encouraged.

https://ift.tt/2zPWcct

KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway [Biochemistry]

Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme...

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CFI-400945 is not a selective cellular PLK4 inhibitor [Biological Sciences]

In the PNAS paper "Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers," Kawakami et al. (1) treat lung cancer cell lines and mouse tumor models with the small molecule CFI-400945 and interpret its effects as being solely due to inhibition of Polo-like kinase 4 (PLK4), the...

https://ift.tt/2qGkTUO

In vivo 3'-to-5' exoribonuclease targetomes of Streptococcus pyogenes [Microbiology]

mRNA decay plays an essential role in the control of gene expression in bacteria. Exoribonucleases (exoRNases), which trim transcripts starting from the 5′ or 3′ end, are particularly important to fully degrade unwanted transcripts and renew the pool of nucleotides available in the cell. While recent techniques have allowed genome-wide...

https://ift.tt/2qJJSq9

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition [Biological Sciences]

In "CFI-400945 is not a selective cellular PLK4 inhibitor," Oegema et al. (1) raise thoughtful comments about our article (2). We appreciate their interest and critique. They propose that CFI-400945 activity was not from Polo-like kinase (PLK4) inhibition and argue that antineoplastic activity was through Aurora B kinase (1), rather...

https://ift.tt/2Flvsa1

Shear heating reconciles thermal models with the metamorphic rock record of subduction [Earth, Atmospheric, and Planetary Sciences]

Some commonly referenced thermal-mechanical models of current subduction zones imply temperatures that are 100–500 °C colder at 30–80-km depth than pressure–temperature conditions determined thermobarometrically from exhumed metamorphic rocks. Accurately inferring subduction zone thermal structure, whether from models or rocks, is crucial for predicting metamorphic reactions and associated fluid release, subarc...

https://ift.tt/2OHJqT4

QnAs with Helmut Schwarz [QnAs]

In the early 1900s, German chemists Fritz Haber and Carl Bosch developed a way to synthesize ammonia from atmospheric nitrogen and methane-derived hydrogen. The method became a vital step in manufacturing not only fertilizers but also explosives. Haber likened the process to making "bread from air" (Haber and Bosch are...

https://ift.tt/2qKWKw9

REM sleep in naps differentially relates to memory consolidation in typical preschoolers and children with Down syndrome [Psychological and Cognitive Sciences]

Sleep is recognized as a physiological state associated with learning, with studies showing that knowledge acquisition improves with naps. Little work has examined sleep-dependent learning in people with developmental disorders, for whom sleep quality is often impaired. We examined the effect of natural, in-home naps on word learning in typical...

https://ift.tt/2zbvxYd

A role of OsROS1 in aleurone development and nutrient improvement in rice [Plant Biology]

DNA methylation is a conserved epigenetic mark in eukaryotes involved in many important biological processes, such as genome integrity, gene imprinting, and gene regulation (1). In genomes, DNA methylation marks can be added through the DNA methylation pathway and can be removed through the DNA demethylation pathway (1). The REPRESSOR...

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Ta2+-mediated ammonia synthesis from N2 and H2 at ambient temperature [Chemistry]

In a full catalytic cycle, bare Ta2+ in the highly diluted gas phase is able to mediate the formation of ammonia in a Haber–Bosch-like process starting from N2 and H2 at ambient temperature. This finding is the result of extensive quantum chemical calculations supported by experiments using Fourier transform ion...

https://ift.tt/2OFKGpC

Top-down causation and quantum physics [Physics]

The nature of emergence of complexity out of the underlying physics is a key issue in understanding the world around us (1). Genuine emergence can be claimed (2–4) to depend on top-down causation, which enables higher emergent levels to direct the outcomes of causation at lower levels to fulfill higher-level...

https://ift.tt/2qMg1gS

Soft conductive micropillar electrode arrays for biologically relevant electrophysiological recording [Engineering]

Multielectrode arrays (MEAs) are essential tools in neural and cardiac research as they provide a means for noninvasive, multiplexed recording of extracellular field potentials with high temporal resolution. To date, the mechanical properties of the electrode material, e.g., its Young's modulus, have not been taken into consideration in most MEA...

https://ift.tt/2z7k38d

Consequences of cesarean delivery for neural development [Neuroscience]

For over 50 million years, every single mammal on Earth had to enter the world through a harrowing passage: the birth canal. The hazards of this journey, short in distance but potentially prolonged in duration, may have peaked in our own species, where the evolution of larger and larger brains...

https://ift.tt/2Fic5Pa

Completely top-down hierarchical structure in quantum mechanics [Physics]

Can a large system be fully characterized using its subsystems via inductive reasoning? Is it possible to completely reduce the behavior of a complex system to the behavior of its simplest "atoms"? In this paper we answer these questions in the negative for a specific class of systems and measurements....

https://ift.tt/2OGO83l

Catalytic enzymes are active matter [Applied Physical Sciences]

Using a microscopic theory to analyze experiments, we demonstrate that enzymes are active matter. Superresolution fluorescence measurements—performed across four orders of magnitude of substrate concentration, with emphasis on the biologically relevant regime around or below the Michaelis–Menten constant—show that catalysis boosts the motion of enzymes to be superdiffusive for a...

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In This Issue [This Week in PNAS]

Cesarean birth and brain development Dying neurons (black) in the hippocampus of a newborn mouse. Previous studies have reported behavioral and cognitive differences between children delivered vaginally versus by cesarean section (C-section), suggesting that birth mode affects brain development. However, medical complications, altered birth timing, and maternal factors associated with...

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Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin [Biophysics and Computational Biology]

A wide range of mutations in the kinesin motor Kif5A have been linked to a neuronal disorder called hereditary spastic paraplegia (HSP). The position of these mutations can vary, and a range of different motile behaviors have been observed, indicating that the HSP mutants can alter distinct aspects of kinesin...

https://ift.tt/2FnINyt

Marginal protein stability drives subcellular proteome isoelectric point [Biophysics and Computational Biology]

There exists a positive correlation between the pH of subcellular compartments and the median isoelectric point (pI) for the associated proteomes. Proteins in the human lysosome—a highly acidic compartment in the cell—have a median pI of ∼6.5, whereas proteins in the more basic mitochondria have a median pI of ∼8.0....

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Microfluidics in structured multimaterial fibers [Engineering]

Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here...

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Opinion: Soil carbon sequestration is an elusive climate mitigation tool [Earth, Atmospheric, and Planetary Sciences]

The need to stabilize the greenhouse gas concentrations of the atmosphere is the great environmental challenge of this century. To control these concentrations, humanity can reduce fossil fuel emissions and/or identify mechanisms to remove greenhouse gases once they have been emitted. The scope of the problem is challenging because of...

https://ift.tt/2OIMTRh

Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy [Applied Biological Sciences]

Amyloidosis is a malignant pathology associated with the formation of proteinaceous amyloid fibrils that deposit in organs and tissues, leading to dysfunction and severe morbidity. More than 25 proteins have been identified as components of amyloid, but the most common form of systemic amyloidosis is associated with the deposition of...

https://ift.tt/2FnIKCN

Common Wrestling Skin Infections | What is That Rash?

As the fall season of sports winds down, the winter sports season will soon be here. That means the return of high school wrestling season. As a sports medicine doctor, we often get the job of doing "skin checks" for wrestling meets along with the athletic trainer. This means checking the skin all over for any signs of infection or fungus that could easily be transmitted to other wrestlers and equipment. It is an important job because skin infections can travel from wrestler to wrestler very easily with the whole team quickly becoming infected. This is something that no trainer, parent or athlete wants to happen.

Why do wrestlers get rashes more often than in other sports? They have a lot more skin-to-skin contact than other sports! During a match they are almost constantly in contact with another player's skin and the mats. They might wrestle several different people in tournaments increasing exposure even more.

Common Wrestling Skin Infections

What are some common infections that wrestlers often get? Two of the most common are ringworm and herpes. Ringworm is a fungus (the fancy name is tinea corporis if it is on your body, tinea capitis if it is on your head) that creates a scaly, circle-shaped rash. It requires a cream applied a few times a day if it is on your body or a medicine by mouth if it is on your head. Herpes is a virus—along the same lines as what causes cold sores. It creates vesicles (fluid-filled spots) that break open and cause red areas on the skin. The first time an athlete gets it, it can cause fevers and flu-like symptoms. It requires a medicine by mouth and can keep coming back year after year.

Prevention of Skin Infections

Can these rashes be prevented? There are definitely many things that can be done on both an individual and a team level to keep these wrestlers healthy and out on the mats.

• Good hygiene! Wrestlers should ideally shower after each practice or meet. Clothes should also be washed after each practice or meet as well.
• No sharing!  Wrestlers should never share towels, razors and soap in the showers. This allows for a fast spread of germs.
• Keep equipment clean: Mats should be cleaned and disinfected before and after use
• When in doubt, check it out: Any area of concern should be checked out by a doctor or trainer ASAP to ensure early detection and treatment.

Following these guidelines can keep your wrestler healthy and out on the mat. Covering or avoiding going to the doctor can sometimes lead to long term consequences in the case of certain rashes. Better to get it checked out and treated early.

The post Common Wrestling Skin Infections | What is That Rash? appeared first on ChildrensMD.

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The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis

Abstract

Background

Suspected lower limb cellulitis presentations are commonly misdiagnoses, resulting in avoidable antibiotic prescribing or hospital admissions. Understanding the challenges posed in diagnosing cellulitis may help enhance future care.

Objectives

To examine and map out the challenges and facilitators identified by patients and health professionals in diagnosing lower limb cellulitis.

Methods

A scoping systematic review was performed in MEDLINE and Embase in October 2017. Thematic analysis was used to identify key themes. Quantitative data was summarised by narrative synthesis.

Results

Three themes were explored: (i) clinical case reports of misdiagnosis, (ii) service development and (iii) diagnostic aids. Forty‐seven different pathologies were misdiagnosed, including seven malignancies. Two different services have been piloted to reduce the misdiagnosis rates of lower limb cellulitis and save costs. Four studies have looked at biochemical markers, imaging and a scoring tool to aid diagnosis.

Conclusions

This review highlights the range of alternative pathologies that can be misdiagnosed as cellulitis, and emerging services and diagnostic aids developed to minimise misdiagnosis. Future work should focus on gaining a greater qualitative understanding of the diagnostic challenges from the perspective of patients and clinicians.

This article is protected by copyright. All rights reserved.

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Issue Information

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An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor-associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome

Federici, S; Vanoni, F; Ben-Chetrit, E; Cantarini, L; Frenkel, J; Goldbach-Mansky, R; Gul, A; ... Pediatric Rheumatology International Trials Organization(PRINTO), .; + view all Federici, S; Vanoni, F; Ben-Chetrit, E; Cantarini, L; Frenkel, J; Goldbach-Mansky, R; Gul, A; Hoffman, H; Koné-Paut, I; Kuemmerle-Deschner, J; Lachmann, HJ; Martini, A; Obici, L; Ozen, S; Simon, A; Hofer, M; Ruperto, N; Gattorno, M; Eurofever, .; Pediatric Rheumatology International Trials Organization(PRINTO), .; - view fewer (2018) An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor-associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome. The Journal of Rheumatology , 45 (11) , Article jrheum.180056. 10.3899/jrheum.180056 .

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A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13

Reglinski, M; Ercoli, G; Plumptre, C; Kay, E; Petersen, FC; Paton, JC; Wren, BW; Reglinski, M; Ercoli, G; Plumptre, C; Kay, E; Petersen, FC; Paton, JC; Wren, BW; Brown, JS; - view fewer (2018) A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13. NPJ Vaccines , 3 , Article 53. 10.1038/s41541-018-0090-4 . Green open access

https://ift.tt/2T8kiYU

Comparative Analysis of Classical and Quantum Plasmons in Graphene Nanostructures

You, JW; Panoiu, NC; (2018) Comparative Analysis of Classical and Quantum Plasmons in Graphene Nanostructures. In: Proceedings of the IEEE: Photonics Society Summer Topical Meeting Series (SUM 2018). (pp. pp. 141-142). IEEE: Danvers (MA), USA. Green open access

https://ift.tt/2zQwyV5

Expert Views on Their Role as Policy Advisor: Pilot Study for the Cases of Electromagnetic Fields, Particulate Matter, and Antimicrobial Resistance

Spruijt, P; Knol, AB; Petersen, AC; Lebret, E; (2018) Expert Views on Their Role as Policy Advisor: Pilot Study for the Cases of Electromagnetic Fields, Particulate Matter, and Antimicrobial Resistance. Risk Analysis 10.1111/risa.13224 . (In press). Green open access

https://ift.tt/2T85Yj0

Private Interests and Private Law Regulation in Public International Law Jurisdiction

Mills, A; (2018) Private Interests and Private Law Regulation in Public International Law Jurisdiction. In: Cragl, P and Allen, S and Guntrip, E and Fitzmaurice, M and Costelloe, D, (eds.) Oxford Handbook on Jurisdiction in International Law. Oxford University Press (In press).

https://ift.tt/2zOFkmI

Trading-off location accuracy and service quality: Privacy concerns and user profiles

Gardner, Z; Leibovici, D; Basiri, A; Foody, G; (2018) Trading-off location accuracy and service quality: Privacy concerns and user profiles. In: Proceedings of the 2017 International Conference on Localization and GNSS (ICL-GNSS). IEEE: Nottingham, UK. Green open access

https://ift.tt/2T8rnZz

Deferred autologous stem cell transplantation in systemic AL amyloidosis

Manwani, R; Hegenbart, U; Mahmood, S; Sachchithanantham, S; Kyriakou, C; Yong, K; Popat, R; ... Wechalekar, A; + view all Manwani, R; Hegenbart, U; Mahmood, S; Sachchithanantham, S; Kyriakou, C; Yong, K; Popat, R; Rabin, N; Whelan, C; Dittrich, T; Kimmich, C; Hawkins, P; Schönland, S; Wechalekar, A; - view fewer (2018) Deferred autologous stem cell transplantation in systemic AL amyloidosis. Blood Cancer Journal , 8 , Article 101. 10.1038/s41408-018-0137-9 . Green open access

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Water Societies and Technologies from the Past and Present

Zhuang, Y and Altaweel, M (Eds). (2018) Water Societies and Technologies from the Past and Present. UCL Press: London, UK. Green open access

https://ift.tt/2T9ItGu

The accuracy of clinical staging of stage I-IIIa non-small cell lung cancer: An analysis based on individual participant data

Navani, N; Fisher, D; Tierney, JF; Stephens, RJ; Burdett, S; NSCLC Meta-analysis Collaborative Group, .; (2018) The accuracy of clinical staging of stage I-IIIa non-small cell lung cancer: An analysis based on individual participant data. Chest 10.1016/j.chest.2018.10.020 . (In press). Green open access

https://ift.tt/2zLWwsS

Exercise: love it, hate it, or somewhere in-between? Identifying exercise self-efficacy and the impact of personal training in children and young people with CF

Douglas, H; Bryon, M; Denford, S; Rand, S; Main, E; (2018) Exercise: love it, hate it, or somewhere in-between? Identifying exercise self-efficacy and the impact of personal training in children and young people with CF. Presented at: 41st European Cystic Fibrosis Conference, Belgrade, Serbia.

https://ift.tt/2T8rhRH

Testing theories of social disorganization in Nigeria

Umar, F; Johnson, SD; Cheshire, JA; (2018) Testing theories of social disorganization in Nigeria. In: Bruinsma, GJN and Johnson, SD, (eds.) The Oxford Handbook of Environmental Criminology. Oxford University Press: Oxford, UK.

https://ift.tt/2zQvJLZ

New Dialysis Technology and Biocompatible Materials

Davenport, A; (2017) New Dialysis Technology and Biocompatible Materials. Scientific Aspects of Dialysis Therapy [series title: Contributions to Nephrology] , 189 pp. 130-136. 10.1159/000450739 .

https://ift.tt/2Tb4y7I

Corruption and the governance of natural disaster risk.

Alexander, DE; (2017) Corruption and the governance of natural disaster risk. In: Oxford Research Encyclopedia of Natural Hazard Science. Oxford University Press: USA.

https://ift.tt/2zZimJJ

Management innovation in complex products and systems: The case of integrated project teams

Roehrich, JK; Davies, A; Frederiksen, L; Sergeeeva, N; (2018) Management innovation in complex products and systems: The case of integrated project teams. Industrial Marketing Management 10.1016/j.indmarman.2018.10.006 . (In press).

https://ift.tt/2Tbm0ZC

Ethics and Aesthetics of Translation

Hulme, HA; (2018) Ethics and Aesthetics of Translation. UCL Press Green open access

https://ift.tt/2zQvnF9

Nebi Younus and Nimrud: report on a site visit made in April 2017

Robson, E; (2018) Nebi Younus and Nimrud: report on a site visit made in April 2017. Sumer. A Journal of Archaeology and History in Arab World , 64 (In press).

https://ift.tt/2T9Io5E

Transportation in Agent-Based Urban Modelling

Wise, S; Crooks, A; Batty, M; (2017) Transportation in Agent-Based Urban Modelling. In: NamaziRad, MR and Padgham, L and Perez, P and Nagel, K and Bazzan, A, (eds.) Proceedings of the International Workshop on Agent Based Modelling of Urban Systems: ABMUS 2016. (pp. pp. 129-148). Springer: Singapore, Singapore. Green open access

https://ift.tt/2zSszHy

Summary report on excavations at Tell Khaiber, an administrative centre of the Sealand period, 2013-2017

Campbell, S; Killick, R; Moon, J; Calderbank, D; Robson, E; (2019) Summary report on excavations at Tell Khaiber, an administrative centre of the Sealand period, 2013-2017. Sumer. A Journal of Archaeology and History in Arab World (In press).

https://ift.tt/2TdqRtt

Assessing the benefits of flexibility in residential and transport sectors with a whole energy systems model, UK TIMES

Li, P; (2018) Assessing the benefits of flexibility in residential and transport sectors with a whole energy systems model, UK TIMES. Presented at: 37th International Energy Workshop (IEW), Gothenburg, Sweden. Green open access

https://ift.tt/2zQutsf

In situ collection of dust grains falling from Saturn's rings into its atmosphere

Hsu, H-W; Schmidt, J; Kempf, S; Postberg, F; Moragas-Klostermeyer, G; Seiß, M; Hoffmann, H; ... Srama, R; + view all Hsu, H-W; Schmidt, J; Kempf, S; Postberg, F; Moragas-Klostermeyer, G; Seiß, M; Hoffmann, H; Burton, M; Ye, S; Kurth, WS; Horányi, M; Khawaja, N; Spahn, F; Schirdewahn, D; O'Donoghue, J; Moore, L; Cuzzi, J; Jones, GH; Srama, R; - view fewer (2018) In situ collection of dust grains falling from Saturn's rings into its atmosphere. Science , 362 (6410) , Article eaat3185. 10.1126/science.aat3185 . Green open access

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Issue Information

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Low-Level Laser in Treatment of Head and Neck Lymphedema: A Pilot Study

Conditions:   Head and Neck Cancer;   Lymphedema;   Fibrosis
Intervention:   Device: Low-Level Laser
Sponsor:   University of Pennsylvania
Recruiting

https://ift.tt/2FwJSEr

Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.

Conditions:   Stage II-IVB Operable HNSCC Oral Cavity;   Hypopharynx;   Oropharynx;   Larynx
Interventions:   Drug: Durvalumab;   Drug: durvalumab + tremelimumab
Sponsor:   Yonsei University
Not yet recruiting

https://ift.tt/2qL8jn4

Study on the Occurrence of Head and Neck Cancers During Pregnancy

Conditions:   Head and Neck Cancer;   Pregnancy Related
Intervention:  
Sponsors:   Centre Francois Baclesse;   French scientific group REFCOR
Not yet recruiting

https://ift.tt/2FjdIvR

Gustatory Function Following Radiotherapy to the Head and Neck

Condition:   Head and Neck Cancer
Interventions:   Other: Olfactory screening;   Other: Quantative Gustatory Testing using Taste Strips
Sponsor:   Royal Marsden NHS Foundation Trust
Recruiting

https://ift.tt/2OJdMEC

Strahlentherapie bei Gliomen

Zusammenfassung

Hintergrund

Die Strahlentherapie (RT) ist eine der wichtigen Säulen der Behandlung von Gliomen. Ständig werden neue Studien zum optimalen Bestrahlungszeitpunkt, der Dosierung und Fraktionierung und zur optimalen Kombination mit anderen Therapieformen publiziert.

Ziel

Die aktuellen Leitlinien und Studienergebnisse werden dargestellt und für die klinische Praxis zusammengefasst.

Material und Methode

Eine Literaturrecherche wurde durchgeführt, und die wichtigsten Publikationen und Leitlinien wurden als Grundlage der Empfehlungen für die klinische Praxis genommen.

Ergebnisse

Für die RT von Low-grade-Gliomen (WHO II) beim Erwachsenen ist das individuelle Risikoprofil entscheidend. Für die Patienten mit erhöhtem Rezidivrisiko ist eine frühe adjuvante RT mit 45–54 Gy empfohlen. Patienten mit High-grade-Gliomen sollten dagegen alle eine adjuvante RT mit einer Dosis von 59,4–60 Gy erhalten. Die Zielvolumendefinition und ob eine konkomittante oder adjuvante Chemotherapie notwendig ist, richtet sich nach dem WHO-Grad und der molekularen Diagnostik. Für Patienten in hohem Alter, mit reduziertem Allgemeinzustand und im Fall von Rezidiven gibt es immer mehr gute strahlentherapeutische Optionen.

Schlussfolgerungen

Die RT von Gliomen ist hinsichtlich der Zielvolumendefinition, Dosis und der Kombination mit Chemotherapie maßgeblich auf die WHO-Klassifikation, die molekulare Diagnostik und den klinischen Allgemeinzustand des Patienten ausgerichtet.

https://ift.tt/2z4SJY8

Salivary duct carcinoma: A prospective multicenter study of 61 cases of the Réseau d'Expertise Français des Cancers ORL Rares

Abstract

Background

The purposes of this study were to describe the characteristics of a prospective multicenter series of patients with salivary duct carcinoma and to investigate prognostic factors.

Methods

Patients included for salivary duct carcinoma between 2009 and 2016 in the Réseau d'Expertise Français des Cancers ORL Rares (REFCOR) database were selected. Immunohistochemical analyses were performed.

Results

Sixty‐one patients were included in this study. The primary site was the parotid gland in 90% of the cases. Fifty‐seven percent of the tumors were stage IV, 65% of patients had lymph node involvement, and 10% had metastases. Tumors showed androgen receptor (89%) and human epidermal growth factor receptor 2 (HER2)/neu (36%). Ninety‐four percent of patients underwent surgery and 86% had postoperative radiotherapy. Six patients were treated with targeted therapies. The 3‐year overall survival (OS) was 74% and the 3‐year disease‐free survival (DFS) was 44%. Tumor stages III to IV reduced DFS (hazard ratio [HR] 4.3; P = .04). The N2/3 class reduced distant metastasis‐free survival (HR 7.3; P = .007).

Conclusion

Salivary duct carcinoma prognosis is poor and is correlated with tumor stage and lymph node classification. Androgen receptor and HER2/neu should be tested as they offer the possibility of targeted therapies.

https://ift.tt/2qLimJ4

Food OIT is Superior to Food Avoidance

Publication date: Available online 13 November 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): J. Andrew Bird

https://ift.tt/2FjMhSu

An Ounce of Caution: Superparamagnetic Iron Oxide Nanoparticle Based MRI Contrast Associated Anaphylaxis

Publication date: Available online 13 November 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Alexander J. Heckman, Anjali Agarwal, Keith A. Sacco, Brett T. Hiroto, Pramod K. Guru

https://ift.tt/2qKctMg

The Effect of Delayed and Early Diagnosis in Siblings, and Importance of Newborn Screening for SCID

Publication date: Available online 12 November 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Matthew S. Krantz, Cosby A. Stone, James A. Connelly, Allison E. Norton, Yasmin W. Khan

https://ift.tt/2FjM7KS

Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway

Publication date: December 2018

Source: Molecular Immunology, Volume 104

Author(s): Xiaojiang Zhan, Caixia Yan, Yanbing Chen, Xin Wei, Jun Xiao, Lijuan Deng, Yuting Yang, Panlin Qiu, Qinkai Chen

Abstract

Diabetic nephropathy (DN) contributes to end-stage renal disease and kidney dysfunction with a proverbial feature of podocyte injury. Inflammation and insulin resistance is recently implicated in the pathogenesis of diabetic kidney injury. Celastrol exerts critical roles in inflammatory diseases and injury progression. However, its function and mechanism in DN remains elusive. Here, celastrol dose-dependently restored podocyte viability under high glucose (HG) conditions, but with little cytotoxicity in podocyte. Preconditioning with celastrol counteracted HG-evoked cell apoptosis, LDH release, ROS production and podocyte depletion. Additionally, HG-elevated high transcripts and secretions of pro-inflammatory cytokines were reversed following celastrol treatment, including IL-1β, TNF-α, IL-6. Simultaneously, the inhibitory effects of HG on insulin-triggered glucose uptake and nephrin expression were overturned after celastrol exposure. Intriguingly, celastrol restored HG-induced deficiency of autophagy pathway. Nevertheless, blocking the autophagy signaling by its antagonist 3-MA muted celastrol-protected against HG-evoked cell injury, inflammation and insulin resistance. Importantly, celastrol enhanced heme oxygenase-1 (HO-1) expression in HG-stimulated podocytes. Notably, HO-1 cessation depressed autophagy pathway activation and subsequently blunted beneficial effects of celastrol on HG-exposed podocytes. These finding suggest that celastrol may protect against HG-induced podocyte injury, inflammation and insulin resistance by restoring HO-1-mediated autophagy pathway, implying a promising therapeutic strategy against DN.

https://ift.tt/2QJFPWs

Detection and location of second mesiobuccal canal in permanent maxillary teeth: a cone-beam computed tomography analysis in a Taiwanese population

Publication date: Available online 12 November 2018

Source: Archives of Oral Biology

Author(s): Chi-Chun Su, Ren-Yeong Huang, Yu-Chiao Wu, Wan-Chien Cheng, Ho-Sheng Chiang, Ming-Pang Chung, Yi-Wen Cathy Tsai, Chi-Hsiang Chung, Yi-Shing Shieh

Abstract

Objectives

The aim of this study was to analyze the incidence, symmetry, concurrence of second mesiobuccal canal (MB2) and determine geometric relationships between each orifice of maxillary first and second molars by cone-beam computed tomography (CBCT) analysis.

Methods

A total of 216 qualified individuals' (503 teeth) CBCT image were enrolled in the present study. The consistency of bilateral symmetry and concurrent appearance of MB2 canals were analyzed among individuals with contralateral and adjacent molar teeth. The inter-orifice distances and angulations of first and second molars were also measured.

Results

The overall incidence of MB2 canal of maxillary molars was 39.2%, in which 45.9% and 32.3% in the first and second molars, respectively. The distribution of MB2 canal in contralateral molar teeth has significant gender difference in second molars (p = 0.024) while analyzing the frequency of MB2 canal appearing in contralateral molar pairs. The simultaneous occurrence of MB2 canal was 22.4% for contralateral molars, and the prevalence of concurrent appearance of MB2 canal in the adjacent molars was 43.4%. After adjusting for gender, age, and tooth type, the inter-orifice distances of mesiobuccal to palatal (odds ratios = 1.891) and to distobuccal (odds ratios = 1.448) canals, demonstrated significant differences between molars with and without MB2 canals.

Conclusions

The clinical significance of the results presents critical information on the geometric features, including inter-orifice distances and angulations between each orifice in maxillary molar teeth. Further studies should be conducted to investigate the exact anatomic coordination between each orifice and its impact on access preparation and external crown morphology.

https://ift.tt/2OEDutP

PERIODONTAL MECHANORECEPTORS AND BRUXISM AT LOW BITE FORCES

Publication date: Available online 12 November 2018

Source: Archives of Oral Biology

Author(s): Gizem Yilmaz, Christopher Laine, Neslihan Tinastepe, M. Gorkem Ozyurt, Kemal S. Türker

Abstract

Objective

In this study, we examined if 6–9 Hz jaw tremor, an indirect indicator of Periodontal Mechanoreceptor (PMR) activity, is different in bruxists compared to healthy participants during production of a low-level constant bite force.

Methods

Bite force and surface EMG from the masseter muscle were recorded simultaneously as participants (13 patients, 15 controls) held a force transducer between the upper and lower incisors very gently.

Results

Tremor in 6–9 Hz band for bruxists was greater on average compared to controls, but the difference was not significant, both for force recordings and EMG activity.

Conclusions

The low effect sizes measured with the current protocol contrast highly with those of our previous study, where larger, dynamic bite forces were used, and where jaw tremor was markedly different in bruxists compared with controls.

Significance

We have now gained important insight into the conditions under which abnormal jaw tremor can be elicited in bruxism. From a scientific standpoint, this is critical for understanding the 'abnormality' of PMR feedback in bruxism. From a clinical perspective, our results represent progress towards the development of an optimal protocol in which jaw tremor can serve as a biological marker of bruxism.

https://ift.tt/2z4Lgs4

Development and use of a mouth gag for oral experiments in rats

Publication date: Available online 12 November 2018

Source: Archives of Oral Biology

Author(s): Ryutaro Kuraji, Shuichi Hashimoto, Hiroshi Ito, Katsuhisa Sunada, Yukihiro Numabe

ABSTRACT

Objective

Rodent models such as mice and rats are often used in investigations of the oral cavity in the fields of periodontology and dental anesthesiology. When various treatments are performed in the oral cavity, it is very important to secure the visual field while keeping the animal's mouth fully opened, in order to ensure the consistency of experimental procedures. Therefore, we developed a standardized gag conforming to various degrees of oral cavity size of different aged rats.

Design

The gag was composed of a rectangular incisor-opening frame constructed from a stainless steel wire with retractors and a dial to alter the opening amounts. Wistar rats (n = 5) aged 4, 8, and 12 weeks were used to evaluate the suitability of the gag in oral cavity. As tests for application of gag in intraoral experiments, the ligature placement around the molars, drug injection into the gingiva, measurement of gingival blood flow rate, and installation of stimulation an electrode for somatosensory-evoked potentials into the molar were performed.

Results

Adjusting the opening dial enabled both the maintenance of open state and more favorable intraoral observation compared with tweezers as a control device in all different types of rats. Furthermore, our gag made it possible to facilitate the insertion of diverse instruments into the oral cavity and to achieve various experimental purposes. The stainless-steel gag can also be autoclaved and dry-heat sterilized.

Conclusion

It was revealed that our mouth gag can be widely applied to various oral experiments in different old aged rats.

https://ift.tt/2OJ3tQW

Loss of an IgG plasma cell checkpoint in lupus

Publication date: Available online 13 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Jolien Suurmond, Yemil Atisha-Fregoso, Emiliano Marasco, Ashley N. Barlev, Naveed Ahmed, Silvia A. Calderon, Mei Yin Wong, Meggan C. Mackay, Cynthia Aranow, Betty Diamond

Abstract

Background

IgG anti-nuclear antibodies (ANA) are a feature of several autoimmune diseases. These antibodies arise through defects in central or peripheral tolerance checkpoints. The specific checkpoints breached in autoimmune disease are not fully understood.

Objectives

To study whether autoreactive plasma cells in lupus models and SLE patients arise as a consequence of defective antigen-specific selection or a global enhancement of IgG PC differentiation.

Methods and Results

We optimized and validated a novel technique to detect naturally occurring ANA+ B cells and PC. We observed a major checkpoint for generation of ANA+ IgG+ PC in both non-autoimmune mice and healthy human subjects. Interestingly, we observed increased numbers of ANA+ IgG+ PC despite normal tolerance checkpoints in immature and naïve B cells in lupus-prone MRL/lpr and NZB/W mice as well as patients with systemic lupus erythematosus (SLE). This increase was due to increased numbers of total IgG+ PC rather than lack of selection against ANA+ PC.

Conclusion

Using a method that permits quick and accurate quantification of autoreactive B cells and PC in vivo within a native B cell repertoire in mice and humans, we demonstrate the importance of a checkpoint that restricts the generation of IgG plasma cells and protects against IgG ANA. Our observations suggest a fundamentally revised understanding of SLE: that it is a disease of aberrant B cell differentiation rather than a defect in antigen-specific B cell tolerance.

Clinical implication

Therapies for SLE might need to be targeted at IgG plasma cell differentiation rather than antigen-specific tolerance.

Graphical abstract

https://ift.tt/2Qzm43r

Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide

Publication date: Available online 12 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Angela L. Nocera, Sarina K. Mueller, Jules R. Stephan, Loretta Hing, Philip Seifert, Xue Han, Derrick T. Lin, Mansoor M. Amiji, Towia Libermann, Benjamin S. Bleier

Background

Nasal mucosa–derived exosomes (NMDEs) harbor immunodefensive proteins and are capable of rapid interepithelial protein transfer.

Objectives

We sought to determine whether mucosal exposure to inhaled pathogens stimulates a defensive swarm of microbiocidal exosomes, which also donate their antimicrobial cargo to adjacent epithelial cells.

Methods

We performed an institutional review board–approved study of healthy NMDE secretion after Toll-like receptor (TLR) 4 stimulation by LPS (12.5 μg/mL) in the presence of TLR4 inhibitors. Interepithelial transfer of exosomal nitric oxide (NO) synthase and nitric oxide was measured by using ELISAs and NO activity assays. Exosomal antimicrobial assays were performed with Pseudomonas aeruginosa. Proteomic analyses were performed by using SOMAscan.

Results

In vivo and in vitro LPS exposure induced a 2-fold increase in NMDE secretion along with a 2-fold increase in exosomal inducible nitric oxide synthase expression and function through TLR4 and inhibitor of nuclear factor κB kinase activation. LPS stimulation increased exosomal microbiocidal activity against P aeruginosa by almost 2 orders of magnitude. LPS-stimulated exosomes induced a 4-fold increase in NO production within autologous epithelial cells with protein transfer within 5 minutes of contact. Pathway analysis of the NMDE proteome revealed 44 additional proteins associated with NO signaling and innate immune function.

Conclusions

We provide direct in vivo evidence for a novel exosome-mediated innate immunosurveillance and defense mechanism of the human upper airway. These findings have implications for lower airway innate immunity, delivery of airway therapeutics, and host microbiome regulation.

Graphical abstract

https://ift.tt/2Pqa0oY

Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability

Publication date: Available online 12 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Susan D'Costa, Saravanan Ayyadurai, Amelia J. Gibson, Emily Mackey, Mrigendra Rajput, Laura J. Sommerville, Neco Wilson, Yihang Li, Eric Kubat, Ananth Kumar, Hariharan Subramanian, Aditi Bhargava, Adam J. Moeser

Abstract

Background

Psychological stress and heightened MC activation are linked with important immunological disorders including allergy, anaphylaxis, asthma, and functional bowel diseases, but the mechanisms remain poorly defined. We have previously demonstrated that activation of the corticotropin releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis and psychological stress, via CRF receptor subtype 1 (CRF₁) expressed on MCs.

Objective

In this study, we investigated the role of CRF receptor subtype 2 (CRF₂) as a modulator of stress-induced MC degranulation and associated disease pathophysiology.

Methods

In vitro MC degranulation assays were performed with bone marrow derived MCs (BMMCs) derived from WT and CRF₂-deficient (CRF₂^-/-) mice and RBL-2H3 MCs transfected with CRF₂-overexpressing plasmid or CRF₂-siRNA. In vivo MC responses and associated pathophysiology in IgE-mediated passive systemic anaphylaxis (PSA) and acute psychological restraint stress were measured in WT, CRF₂^-/-, and MC-deficient Kit^W-sh/W-sh knock-in mice.

Results

Compared with WT mice, CRF2-/- exhibited heightened serum histamine levels and exacerbated PSA-induced anaphylactic responses and colonic permeability. In addition, CRF₂^-/- mice exhibited increased serum histamine and colonic permeability following acute restraint stress. Experiments with BMMCs and RBL-2H3 MCs demonstrated that CRF₂ expressed on MCs suppresses store-operated Ca²⁺ entry (SOCE) signaling and MC degranulation induced by diverse MC stimuli. Experiments with MC-deficient Kit^W-sh/W-sh mice systemically engrafted with WT and CRF₂^-/- BMMCs demonstrated the functional importance of MC-CRF₂ in modulating stress-induced pathophysiology.

Conclusions

MC CRF₂ is a negative, global modulator of stimuli-induced MC degranulation and limits the severity of IgE-mediated anaphylaxis and stress-related disease pathogenesis.

Graphical abstract

https://ift.tt/2QFQMZ4

Extranodal extension in resected oral cavity squamous cell carcinoma: more to it than meets the eye

Objective/Hypothesis

Extranodal extension (ENE) is an independent prognosticator in head–neck Squamous cell carcinoma (SCC). All patients with ENE, however, do not behave the same, and there is a need for further risk stratification. This study evaluates the prognostic significance of various grades of ENE and the number of nodes with ENE on overall survival (OS) in oral cavity SCC (OCSCC).

Study Design

Retrospective cohort study.

Methods

Ninety‐four patients with node‐positive OCSCC treated with primary surgery and appropriate adjuvant therapy during the year 2011 were evaluated. Surgical histopathology slides of all patients were reviewed, and ENE was graded according to the grading system proposed by Lewis Jr et al.

Results

On univariate analysis, lymph node density (LND) greater than or equal to 0.12 (P = 0.013), the presence of ENE in more than two nodes (P = 0.006), and ENE grade 3 through 4 (P = 0.035) were associated with worse (OS). Conventional prognostic factors such as tumor (T) stage, nodal (N) stage, stage grouping, depth of invasion, and pattern of invasion did not have a significant impact on OS. On multivariate analysis, the presence of ENE in more than two nodes (P = 0.018) independently predicted a worse OS. Extranodal extension grade 3 through 4 showed a trend toward significance (P = 0.08). A combination of LND greater than or equal to 0.12, ENE grade 3 through 4, and ENE in more than two lymph nodes conferred the poorest prognosis (3‐year OS: 18%; P = 0.000).

Conclusion

In patients with ENE and advanced nodal disease, T stage, N stage, stage group, depth, and pattern of invasion lose their impact on OS. In patients with ENE, nodal characteristics such as LND, the number of nodes with ENE, and grade of ENE serve as important prognosticators and aid in further risk stratification.

Level of Evidence

4. Laryngoscope, 2018

https://ift.tt/2QLAei0

Cochlear implantation after canal wall down mastoidectomy — Outcomes after partial mastoid obliteration

Publication date: Available online 12 November 2018

Source: Auris Nasus Larynx

Author(s): Matthias Balk, David Schwarz, Philipp Wolber, Andreas Anagiotos, Antoniu-Oreste Gostian

Abstract

Objective

To describe and evaluate the partial mastoid obliteration of the so-called radical mastoid cavity after canal-wall down mastoidectomy (CWD) for cochlear implantation (CI) compared to overclosure of the external ear canal as two stage procedures.

Methods

Out of 1020 patients undergoing cochlear implantation between January 1st, 2003 and June 15th, 2016 at the Department of Otolaryngology, Head & Neck Surgery, University Hospital Cologne, eight patients underwent obliteration of the radical cavity prior to cochlear implantation. In four additional patients, the external ear canal was overclosed prior to cochlear implantation.

Results

Patients undergoing partial mastoid obliteration (five ♀, 4 left ears) and overclosure of the external ear canal (one ♀, 3 left ears) averaged 56 years and 61 years, respectively. The radical cavities had been present for 21.8 years on average before partial obliteration and for 19.5 years before overclosure. Cochlear implantation following mastoid obliteration was performed after a mean period of 5.1 months and 3.8 months after overclosure. After partial mastoid obliteration, complete insertion of all electrodes was achieved and the clinical courses were uneventful for all patients. Likewise, no patient revealed any complications after overclosure of the external ear canal.

Conclusion

Partial mastoid obliteration with bone paté and cartilage after canal wall down mastoidectomy can be advocated as a feasible alternative technique that allows for a safe subsequent cochlear implantation.

https://ift.tt/2QDa6pD

Effects of l-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Publication date: Available online 12 November 2018

Source: Auris Nasus Larynx

Author(s): Kazuhira Endo, Takayoshi Ueno, Kazuya Ishikawa, Yosuke Nakanishi, Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki

Abstract

Objectives

Cancer-related fatigue impairs daily functioning and negatively impacts health-related quality of life (HRQoL). Our previous study revealed that cisplatin-based chemoradiotherapy (CRT) impairs the carnitine system and carnitine deficiency leads to poor physical functioning. This open label, randomized, controlled prospective study investigated the effects of l-carnitine administration on plasma carnitine concentration, CRT-induced fatigue, and decline in HRQoL in patients with head and neck squamous cell carcinoma (HNSCC).

Methods

Patients were divided into experimental group (received 1000 mg of oral liquid l-carnitine once daily for 8 weeks) and control group. The primary and secondary endpoints were the change in HRQoL scores and the change in carnitine levels, respectively, from baseline (pre-CRT) to after CRT.

Results

The mean total plasma carnitine concentration in the control group decreased significantly, 2 weeks after the end of chemotherapy, while no significant differences were seen in the l-carnitine group. l-carnitine administration, therefore, kept the physical functioning score unchanged.

Conclusion

Our study shows that patients who receive CRT experience chemotherapy-induced damage of carnitine homeostasis leading to deficiency of carnitine and impairment of HRQoL. l-carnitine administration is beneficial in improving the HRQoL in patients with HNSCC.

https://ift.tt/2QCGhp7

Curcumin gum formulation for prevention of oral cavity head and neck squamous cell carcinoma

Objectives/Hypothesis

Head and neck squamous cell carcinoma represents the sixth most common cancer. As a result of field cancerization, second primaries and recurrences are high. Hence, research has focused on chemoprevention. Curcumin, a polyphenol compound with anticarcinogenic properties, is one such promising nutraceutical. As poor bioavailability limits curcumin's use, a novel gum formulation was tested allowing for direct mucosal absorption into the bloodstream. This preliminary study validates curcumin gum efficacy by assessing release and transmucosal absorption, along with measuring its effects on serum cytokine levels.

Study Design

Clinical trial.

Methods

Protocols consisting of initial chew (chewing gum for 30 minutes) and revised chew (alternating chewing and parking gum against buccal mucosa for 30 minutes) were tested in healthy volunteers. High‐performance liquid chromatography measured remnant curcumin in chewed gum, serum, and saliva. Serum levels were assayed for 15 proinflammatory cytokines via multiplex analysis.

Results

Revised chew samples demonstrated significantly higher curcumin release and absorption (P = .0078). Curcumin serum levels were significantly higher at 4 hours in samples > 2.0 g of curcumin release (P = .01). As saliva levels decreased, a concurrent increase in serum levels was observed, with no significance in the inverse relationship (P = .1423). When evaluating differences between gender, race, and age, the Asian population showed significantly lower curcumin release and serum levels (P = .009). CXCL1 (GRO‐α) and TNF‐α were significantly decreased in serum after chewing the gum (P = .036, P < .001, respectively).

Conclusions

Enhanced mucosal contact appears critical in improving curcumin release and absorption. CXCL1 and TNF‐α both represent potential biomarkers for the future study of curcumin chemoprevention.

Level of Evidence

2b Laryngoscope, 2018

https://ift.tt/2QE7YOB

Origin of the low-temperature endotherm of acid-doped ice VI: new hydrogen-ordered phase of ice or deep glassy states?

Rosu-Finsen, A; Salzmann, CG; (2018) Origin of the low-temperature endotherm of acid-doped ice VI: new hydrogen-ordered phase of ice or deep glassy states? Chemical Science 10.1039/C8SC03647K . (In press). Green open access

https://ift.tt/2z6OPOg

Gamification as a tool for resident education in otolaryngology: A pilot study

https://ift.tt/2QCope3

"I don’t know": a usage-based approach to familiar collocations in non-fluent aphasia

Bruns, C; Varley, R; Zimmerer, V; Carragher, M; Brekelmans, G; Beeke, S; (2018) "I don't know": a usage-based approach to familiar collocations in non-fluent aphasia. Aphasiology 10.1080/02687038.2018.1535692 . (In press).

https://ift.tt/2ODxEc5

The interaction of beta 2-microglobulin with gold nanoparticles: impact of coating, charge and size

Cantarutti, C; Bertoncin, P; Posocco, P; Hunashal, Y; Giorgetti, S; Bellotti, V; Fogolari, F; Cantarutti, C; Bertoncin, P; Posocco, P; Hunashal, Y; Giorgetti, S; Bellotti, V; Fogolari, F; Esposito, G; - view fewer (2018) The interaction of beta 2-microglobulin with gold nanoparticles: impact of coating, charge and size. Journal of Materials Chemistry B , 6 (37) pp. 5964-5974. 10.1039/c8tb01129j .

https://ift.tt/2ODxv8x

Household structure and its association with sexual risk behaviours and sexual health outcomes: Evidence from a British probability sample survey

Curtis, TJ; (2019) Household structure and its association with sexual risk behaviours and sexual health outcomes: Evidence from a British probability sample survey. BMJ Open 10.1136/bmjopen-2018-024255 . (In press).

https://ift.tt/2z6oboZ

The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study

Sami, SS; Ragunath, K; Wilkes, EA; James, M; Mansilla-Vivar, R; Ortiz-Fernandez-Sordo, J; White, J; ... Guha, IN; + view all Sami, SS; Ragunath, K; Wilkes, EA; James, M; Mansilla-Vivar, R; Ortiz-Fernandez-Sordo, J; White, J; Khanna, A; Coletta, M; Samuel, S; Aithal, GP; Guha, IN; - view fewer (2016) The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a prospective diagnostic pilot study. Liver International , 36 (11) pp. 1639-1648. 10.1111/liv.13152 . Green open access

https://ift.tt/2OH1ixc

Evaluation of a novel infra-red endoscopy system in the assessment of early neoplasia in Barretts esophagus: pilot study from a single center

Ortiz-Fernandez-Sordo, J; Sami, SS; Mansilla-Vivar, R; Subramanian, V; Mannath, J; Telakis, E; Ragunath, K; (2018) Evaluation of a novel infra-red endoscopy system in the assessment of early neoplasia in Barretts esophagus: pilot study from a single center. Diseases of the Esophagus , 31 (3) , Article dox137. 10.1093/dote/dox137 .

https://ift.tt/2z8Y94q

Problems of dual vulnerability in nutrition: A qualitative study of older persons caring for under 5-year-olds in post-disaster Haiti

Raybould, S; Ward, T; Burnett, R; Manikam, L; Tibe, M; Munslow, B; (2018) Problems of dual vulnerability in nutrition: A qualitative study of older persons caring for under 5-year-olds in post-disaster Haiti. International Journal of Health Planning and Management , 33 (2) pp. 524-531. 10.1002/hpm.2477 .

https://ift.tt/2OLxHTy

Cohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study: a prospective multicentre cohort study in critically ill children

Feinstein, Y; Walker, JC; Peters, MJ; Nadel, S; Pathan, N; Edmonds, N; Herberg, J; ... Ramnarayan, P; + view all Feinstein, Y; Walker, JC; Peters, MJ; Nadel, S; Pathan, N; Edmonds, N; Herberg, J; Kaforou, M; Wright, V; Levin, M; Ramnarayan, P; - view fewer (2018) Cohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study: a prospective multicentre cohort study in critically ill children. BMJ Open , 8 (11) , Article e024729. 10.1136/bmjopen-2018-024729 . Green open access

https://ift.tt/2z7eJS5

Anxiety disorder symptoms at age 10 predict eating disorder symptoms and diagnoses in adolescence

Schaumberg, K; Zerwas, S; Goodman, E; Yilmaz, Z; Bulik, CM; Micali, N; (2018) Anxiety disorder symptoms at age 10 predict eating disorder symptoms and diagnoses in adolescence. Journal of Child Psychology and Psychiatry 10.1111/jcpp.12984 .

https://ift.tt/2OLx4ta

Recent Advances in Screening for Barrett's Esophagus

Sami, SS; Iyer, PG; (2018) Recent Advances in Screening for Barrett's Esophagus. Current Treatment Options in Gastroenterology , 16 (1) pp. 1-14. 10.1007/s11938-018-0166-2 .

https://ift.tt/2z8cyxz

Lamin mutation location predicts cardiac phenotype severity: combined analysis of the published literature

Captur, G; James, M; Petros, S; William, M; Eloisa, A; DIna, R; Ben, O; (2018) Lamin mutation location predicts cardiac phenotype severity: combined analysis of the published literature. Open Heart , 5 (2) , Article e000915. 10.1136/openhrt-2018-000915 . Green open access

https://ift.tt/2OLwITm

Engineered Models of Metastasis with Application to Study Cancer Biomechanics

Chen, MB; Kamm, RD; Moeendarbary, E; (2018) Engineered Models of Metastasis with Application to Study Cancer Biomechanics. In: Dong, C and Zahir, N and Konstantopoulos, K, (eds.) Biomechanics in Oncology. (pp. 189-207). Springer Nature: Cham, Switzerland.

https://ift.tt/2z7eiap

Non-invasive tests for the detection of oesophageal varices in compensated cirrhosis: systematic review and meta-analysis

Sami, SS; Harman, D; Ragunath, K; Bohning, D; Parkes, J; Guha, IN; (2018) Non-invasive tests for the detection of oesophageal varices in compensated cirrhosis: systematic review and meta-analysis. United European Gastroenterology Journal , 6 (6) pp. 806-818. 10.1177/2050640618767604 . Green open access

https://ift.tt/2OLwADm

Innovations in and the changing landscape of geography education with Geographic Information Systems

Rickles, P; Ellul, C; (2017) Innovations in and the changing landscape of geography education with Geographic Information Systems. Journal of Geography in Higher Education , 41 (3) pp. 305-309. 10.1080/03098265.2017.1331210 . Green open access

https://ift.tt/2z7ebvv

The quality of studies evaluating antimicrobial stewardship interventions: a systematic review

Schweitzer, V; van Heilj, I; van Werkhoven, CH; Islam, J; Hendriks-Spoor, K; Bielicki, J; Bonten, MJM; ... Llewelyn, MJ; + view all Schweitzer, V; van Heilj, I; van Werkhoven, CH; Islam, J; Hendriks-Spoor, K; Bielicki, J; Bonten, MJM; Walker, AS; Llewelyn, MJ; - view fewer (2019) The quality of studies evaluating antimicrobial stewardship interventions: a systematic review. Clinical Microbiology and Infection (In press).

https://ift.tt/2OLwtYs

The Lake CHAd Deep DRILLing project (CHADRILL) - targeting ~ 10 million years of environmental and climate change in Africa

Sylvestre, F; Schuster, M; Vogel, H; Abdheramane, M; Ariztegui, D; Salzmann, U; Schwalb, A; ... Viehberg, F; + view all Sylvestre, F; Schuster, M; Vogel, H; Abdheramane, M; Ariztegui, D; Salzmann, U; Schwalb, A; Waldmann, N; Adeaga, O; Ahounta, D; Izuchukwu, MA; Andossa, L; Armitage, S; Augustin, L; Barboni, D; Bard, E; Berke, M; Bouchez, C; Bourlès, D; Bristow, C; Brown, E; Campisano, C; Chalié, F; Clarke, L; Contoux, C; Couapel, M; Delanghe, D; Deschamps, P; Doumnang, JC; Flecker, R; Harms, U; Holmes, J; Phillips, RI; Isseini, M; Jouve, G; Larrasoana, J; Lebatard, AE; Leroy, S; Mahamoud, Y; Moussa, A; Nielson, D; Nguetsop, F; Njokuocha, RC; Noren, A; Porat, N; Chloé, P; Schüler-Goldbach, L; Tachikawa, K; Thouveny, N; Tutolo, B; Verschuren, D; Vidal, L; Viehberg, F; - view fewer (2018) The Lake CHAd Deep DRILLing project (CHADRILL) - targeting ~ 10 million years of environmental and climate change in Africa. Scientific Drilling , 24 pp. 71-78. 10.5194/sd-24-71-2018 . Green open access

https://ift.tt/2z5twwQ

American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock

Davis, AL; Carcillo, JA; Aneja, RK; Deymann, AJ; Lin, JC; Nguyen, TC; Okhuysen-Cawley, RS; ... Zuckerberg, AL; + view all Davis, AL; Carcillo, JA; Aneja, RK; Deymann, AJ; Lin, JC; Nguyen, TC; Okhuysen-Cawley, RS; Relvas, MS; Rozenfeld, RA; Skippen, PW; Stojadinovic, BT; Williams, EA; Yeh, TS; Balamuth, F; Brierley, J; de Caen, AR; Cheifetz, IM; Choong, K; Conway, E; Cornell, T; Doctor, A; Dugas, M-A; Feldman, JD; Fitzgerald, JC; Flori, HR; Fortenberry, JD; Graciano, AL; Greenwald, BM; Hall, MW; Han, YY; Hernan, LJ; Irazurta, JE; Iselin, E; van der Jagt, EW; Jeffries, HE; Kache, S; Katyal, C; Kissoon, NT; Kon, AA; Kutko, MC; MacLaren, G; Maul, T; Mehta, R; Odetola, F; Parbuoni, K; Paul, R; Peters, MJ; Ranjit, S; Reuter-Rice, KE; Schnitzler, EJ; Scott, HF; Torres, A; Weingarten-Abrams, J; Weiss, SL; Zimmerman, JJ; Zuckerberg, AL; - view fewer (2017) American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Critical Care Medicine , 45 (6) pp. 1061-1093. 10.1097/CCM.0000000000002425 . Green open access

https://ift.tt/2OLwmMw

Influence of cellular structures of skin on fiber activation thresholds and computation cost

Salkim, E; Shiraz, A; Demosthenous, A; (2018) Influence of cellular structures of skin on fiber activation thresholds and computation cost. Biomedical Physics & Engineering Express , 5 (1) , Article 015015. 10.1088/2057-1976/aaeaad . Green open access

https://ift.tt/2z2xvKo

Estimation of lean body mass by creatinine kinetics increases the prevalence of muscle wasting in peritoneal dialysis patients compared to bioimpedance

Yoowannakul, S; Davenport, A; (2018) Estimation of lean body mass by creatinine kinetics increases the prevalence of muscle wasting in peritoneal dialysis patients compared to bioimpedance. European Journal of Clinical Nutritionvolume , 72 (10) pp. 1455-1457. 10.1038/s41430-017-0072-z . Green open access

https://ift.tt/2OGUNdJ

Effects of oral isotretinoin therapy on the nasal cavities

Publication date: Available online 12 November 2018

Source: Brazilian Journal of Otorhinolaryngology

Author(s): Hamdi Tasli, Aslan Yurekli, Mert Cemal Gokgoz, Omer Karakoc

Abstract

Introduction

Isotretinoin (13 cis-retinoic acid) is the most effective treatment for acne vulgaris and is the only treatment option that can provide either remission or a permanent cure.

Objective

The aim of this study was to use both subjective and objective methods to assess the nasal complaints of patients with severe acne who received oral isotretinoin therapy.

Methods

Fifty-four subjects were enrolled in the study. All the subjects were assessed with subjective (NOSE and VAS questionnaires) and objective (rhinomanometry and saccharine) tests to determine the severity of their nasal complaints.

Results

The mean severity scores (min: 0; max: 100) for nasal dryness/crusting and epistaxis were 0.47 ± 1.48 (0–5); 0.35 ± 1.30 (0–5) at admission, 3.57 ± 4.45 (0–10); 2.26 ± 4.71 (0–20) at the first month, and 4.28 ± 6 (0–20); 2.26 ± 4.71 (0–20) at the third month of the treatment respectively. Total nasal resistance of 0.195 ± 0.079 (0.12–0.56) Pa/cm³/s at admission, 0.21 ± 0.084 (0.12–0.54) Pa/cm³/s at the first month, and 0.216 ± 0.081 (0.14–0.54) Pa/cm³/s at the third month.

Conclusion

Oral isotretinoin therapy can cause the complaint of nasal obstruction. In addition, nasal complaints, such as dryness/crusting and epistaxis, significantly increase in patients during the therapy schedule.

Resumo

Introdução

A isotretinoína (ácido-13 cis-retinóico) é o tratamento por via oral mais eficaz para acne vulgar e é a única opção de tratamento que pode produzir remissão ou cura permanente.

Objetivo

O objetivo deste estudo foi utilizar métodos subjetivos e objetivos para avaliar as queixas nasais de pacientes com acne grave que receberam terapia com isotretinoína oral.

Método

Cinquenta e quatro indivíduos foram incluídos no estudo. Todos os indivíduos foram avaliados por meio de testes subjetivos (questionários NOSE e escala EVA) e objetivos (rinomanometria e teste de sacarina) para determinar a gravidade de suas queixas nasais.

Resultados

Os escores médios de gravidade (min: 0; max: 100) para ressecamento/crostas e epistaxe nasal foram de 0,47 ± 1,48 (0-5); 0,35 ± 1,30 (0-5) no início, 3,57 ± 4,45 (0-10); 2,26 ± 4,71 (0-20) no primeiro mês e 4,28 ± 6 (0-20); 2,26 ± 4,71 (0-20) no terceiro mês do tratamento, respectivamente. A resistência nasal total foi de 0,195 ± 0,079 (0,12 a 0,56) Pa/cm³/s no início, 0,21 ± 0,084 (0,12 a 0,54) Pa/cm³/s no primeiro mês e 0,216 ± 0,081 (0,14 a 0,54) Pa/cm³/s no terceiro mês.

Conclusão

A terapia com isotretinoína por via oral pode resultar em queixa de obstrução nasal. Além disso, queixas nasais tais como ressecamento/formação de crostas e epistaxe, aumentam significativamente nos pacientes durante o esquema terapêutico.

https://ift.tt/2B2F9pF

The absence of Rab27a accelerates the degradation of Melanophilin

Abstract

Melanophilin (Mlph) forms an interaction with Rab27a and the actin‐based motor protein MyosinVa (MyoVa) on mature melanosome membranes and the tripartite complex regulates melanosome transport in melanocytes. In this study, we found that Rab27a siRNA decreased Mlph and Rab27a protein levels, but Mlph mRNA levels were not changed. Other Rab27a siRNA sequences also showed the same results. When Rab27a siRNA was treated with melan‐a melanocytes, Rab27a protein was decreased within 6 h and Mlph protein was decreased within 24 h. To determine whether the absence of Rab27a promotes Mlph degradation, we inhibited protein degradation by treatment with proteasome (MG132) and lysosomal enzyme (E64D and Pepstatin A) inhibitors in melan‐a melanocytes. MG132 inhibited the degradation of Mlph, but E64D and Pepstatin A had no effect on Mlph. The absence of Rab27a enhanced ubiquitination of Mlph and induced proteasomal degradation. From these results, we concluded that Mlph interaction with Rab27a is important for Mlph stability and melanosome transport.

This article is protected by copyright. All rights reserved.

https://ift.tt/2K23gY8

Depilatory chemical thioglycolate affects hair cuticle and cortex, degrades epidermal cornified envelopes and induces proliferation and differentiation responses in keratinocytes

Abstract

Thioglycolate is a potent depilatory agent. In addition, it has been proposed to be useful as a penetration enhancer for transepidermal drug delivery. However, the effects on hair structure and stress responses it elicits in epidermal keratinocytes have not been fully characterized. We have used label‐free confocal and fluorescence lifetime imaging supported by electron microscopy to demonstrate how thioglycolate damages hair cuticle cells by generating breakages along the endocuticle and leading to swelling of cortex cells. Maleimide staining of free SH‐groups and a decrease in the average fluorescence lifetime of endogenous fluorophores demonstrate a specific change in protein structure in both hair cuticle and cortex. We found that the thioglycolate damages cornified envelopes isolated from the stratum corneum of the epidermis. However, thioglycolate‐treated epidermal equivalent cultures recover within 48 hours, which highlights the reversibility of the damage. HaCaT keratinocytes respond to thioglycolate by increased proliferation, onset of differentiation and expression of the chaperone protein Hsp 70, but not Hsp 27. Up‐regulation of involucrin can be blocked by an application of c‐Jun N–terminal kinase (JNK) inhibitor, but the up‐regulation of Hsp 70 takes place regardless of the presence of the JNK inhibitor.

This article is protected by copyright. All rights reserved.

https://ift.tt/2B47rjt

A paediatric puzzle: pulsating, pruritic papules and plaques

https://ift.tt/2QJz0UQ

The Invisible Costs of Hearing Loss.

The Invisible Costs of Hearing Loss.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: McKee MM

PMID: 30419139 [PubMed - as supplied by publisher]

https://ift.tt/2zKEaby

Incident Hearing Loss and Comorbidity: A Longitudinal Administrative Claims Study.

Incident Hearing Loss and Comorbidity: A Longitudinal Administrative Claims Study.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Deal JA, Reed NS, Kravetz AD, Weinreich H, Yeh C, Lin FR, Altan A

Abstract
Importance: Because hearing loss is highly prevalent and treatable, determining its association with morbidity has major public health implications for disease prevention and the maintenance of health in adults with hearing loss.
Objective: To investigate the association between the diagnosis of incident hearing loss and medical comorbidities in adults 50 years or older.
Design, Setting, and Participants: Retrospective, propensity-matched cohort study using administrative claims data from commercially insured and Medicare Advantage members in a geographically diverse US health plan. Adults 50 years or older with claims for services rendered from January 1, 2000, to December 31, 2016, were observed for 2 (n = 154 414), 5 (n = 44 852), and 10 (n = 4728) years. This research was conceptualized and data were analyzed between September 2016 and November 2017.
Exposures: A claim for incident hearing loss is defined as 2 claims for hearing loss within 2 consecutive years without evidence of hearing device use, excluding claims for sudden hearing loss or hearing loss secondary to medical conditions.
Main Outcomes and Measures: Incident claims for dementia, depression, accidental falls, nonvertebral fractures, acute myocardial infarction, and stroke.
Results: After cohort matching, 48% of participants were women (n = 74 464), 61% were white (n = 93 442), and 31% (n = 48 056) were Medicare Advantage insured, with a mean (SD) age of 64 (10) years. In a multivariate-adjusted modified Poisson regression with robust standard errors, relative associations were strongest for dementia (relative risk at 5 years, 1.50; 95% CI, 1.38-1.64) and depression (relative risk at 5 years, 1.41; 95% CI, 1.26-1.58). The absolute risk of all outcomes was greater in persons with hearing loss than in those without hearing loss at all times, with the greatest risk difference observed at 10 years for all outcomes. The 10-year risk attributable to hearing loss was 3.20 per 100 persons (95% CI, 1.76-4.63) for dementia, 3.57 per 100 persons (95% CI, 1.67-5.47) for falls, and 6.88 per 100 persons (95% CI, 4.62-9.14) for depression.
Conclusions and Relevance: In this large observational study using administrative claims data, incident untreated hearing loss was associated with greater incident morbidity than no hearing loss across a range of health conditions. Future studies are needed to elucidate the mechanisms underlying these associations and to determine if treatment for hearing loss could reduce the risk of comorbidity.

PMID: 30419134 [PubMed - as supplied by publisher]

https://ift.tt/2T6Ticd

Analysis of Clinical Features of Mammary Analog Secretory Carcinoma Using the Surveillance, Epidemiology, and End Results Database.

Analysis of Clinical Features of Mammary Analog Secretory Carcinoma Using the Surveillance, Epidemiology, and End Results Database.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Anderson JL, Haidar YM, Armstrong WB, Tjoa T

PMID: 30419133 [PubMed - as supplied by publisher]

https://ift.tt/2zNjXSv

Trends in Health Care Costs and Utilization Associated With Untreated Hearing Loss Over 10 Years.

Trends in Health Care Costs and Utilization Associated With Untreated Hearing Loss Over 10 Years.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Reed NS, Altan A, Deal JA, Yeh C, Kravetz AD, Wallhagen M, Lin FR

Abstract
Importance: Nearly 38 million individuals in the United States have untreated hearing loss, which is associated with cognitive and functional decline. National initiatives to address hearing loss are currently under way.
Objective: To determine whether untreated hearing loss is associated with increased health care cost and utilization on the basis of data from a claims database.
Design, Setting, Participants: Retrospective, propensity-matched cohort study of persons with and without untreated hearing loss based on claims for health services rendered between January 1, 1999, and December 31, 2016, from a large health insurance database. There were 154 414, 44 852, and 4728 participants at the 2-, 5-, and 10-year follow-up periods, respectively. The study was conceptualized and data were analyzed between September 2016 and November 2017.
Exposures: Untreated hearing loss (ie, hearing loss that has not been treated with hearing devices) was identified via claims measures.
Main Outcomes and Measures: Medical costs, inpatient hospitalizations, total days hospitalized, 30-day hospital readmission, emergency department visits, and days with at least 1 outpatient visit.
Results: Among 4728 matched adults (mean age at baseline, 61 years; 2280 women and 2448 men), untreated hearing loss was associated with $22 434 (95% CI, $18 219-$26 648) or 46% higher total health care costs over a 10-year period compared with costs for those without hearing loss. Persons with untreated hearing loss experienced more inpatient stays (incidence rate ratio, 1.47; 95% CI, 1.29-1.68) and were at greater risk for 30-day hospital readmission (relative risk, 1.44; 95% CI, 1.14-1.81) at 10 years postindex. Similar trends were observed at 2- and 5-year time points across measures.
Conclusions and Relevance: Older adults with untreated hearing loss experience higher health care costs and utilization patterns compared with adults without hearing loss. To further define this association, additional research on mediators, such as treatment adherence, and mitigation strategies is needed.

PMID: 30419131 [PubMed - as supplied by publisher]

https://ift.tt/2T6T057

Epidemiologic, Imaging, Audiologic, Clinical, Surgical, and Prognostic Issues in Common Cavity Deformity: A Narrative Review.

Epidemiologic, Imaging, Audiologic, Clinical, Surgical, and Prognostic Issues in Common Cavity Deformity: A Narrative Review.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Brotto D, Avato I, Lovo E, Muraro E, Bovo R, Trevisi P, Martini A, Manara R

Abstract
Importance: Common cavity deformity is a rare congenital inner ear malformation associated with profound hearing loss and attributed to an early developmental arrest of the cochlear-vestibular structures. This narrative review highlights the need to identify reliable indicators of hearing rehabilitation outcome.
Observations: Despite its relatively simple definition, common cavity deformity varies widely in morphologic features, presence of cochlear nerve fibers and remnants of Corti organ, and outcome after cochlear or brainstem implant.
Conclusions and Relevance: Cochlear implant has been shown to be a valid option for common cavity deformity, but its outcome remains variable and poor. Identification of specific neuroradiologic, audiologic, and neurophysiologic prognostic features; tailoring of the surgical approach; and standardization of outcome measures are needed to optimize the management of common cavity deformity and hearing rehabilitation after implant.

PMID: 30419122 [PubMed - as supplied by publisher]

https://ift.tt/2zLikF0

Association of Age-Related Hearing Loss With Multiple Adverse Health Outcomes.

Association of Age-Related Hearing Loss With Multiple Adverse Health Outcomes.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Loughrey D

PMID: 30419115 [PubMed - as supplied by publisher]

https://ift.tt/2T6SMeh

Severe Nasal Swelling.

Severe Nasal Swelling.

JAMA Otolaryngol Head Neck Surg. 2018 Nov 08;:

Authors: Goldman-Yassen A, Bello J, Shifteh K

PMID: 30419094 [PubMed - as supplied by publisher]

https://ift.tt/2zLi4Wy

Simultaneous four‐channel recording of bilateral cervical and ocular vestibular‐evoked myogenic potentials in response to stimulation by forehead bone‐conducted vibration: Our experience in 20 healthy adults

Abstract

Various vestibular stimuli, including air‐conducted sound (ACS), bone‐conducted vibration (BCV), and galvanic vestibular stimulation (GVS), can be used to elicit vestibular‐evoked myogenic potential (VEMP). VEMP obtained from the sternocleidomastoid (SCM) muscle is called cervical VEMP (cVEMP), while that recorded at extraocular muscles is termed ocular VEMP (oVEMP). cVEMP was first recognized as fundamental in determining the sacculo‐collic reflex (SCR) pathway in the mid‐1990s. In the mid‐2000s, oVEMP was successfully recorded and emerged as the basis for a promising examination for evaluating the integrity of the vestibulo‐ocular reflex (VOR) pathway.

This article is protected by copyright. All rights reserved.

https://ift.tt/2PSoe1c

Implementation of modern tools in autopsy practice—the way towards contemporary postmortal diagnostics

Abstract

Medical, legal, and socioeconomic issues have contributed to the decline of autopsy rates. Pathology-related factors, however, with changing clinical duties on the one hand and decreasing interest and lack of substantial technical developments in this field on the other, may have contributed to this condition as well. We present our experience of a restructuring project that culminated in the introduction of a modernized postmortal diagnostic (PMD) unit: Workflows of PMD procedures and space organization were restructured according to LEAN management principles method. Classical autopsy suites were transformed into postmortal operating rooms. A PMD pathologist staff was designated to perform postmortal operative diagnostics (i.e., using laparotomy and thoracotomy approaches) with the intention of gradually replacing classical autopsy procedures. Postmortal minimal invasive diagnostics (PMID) using laparoscopy and thoracoscopy were successfully implemented with the expertise of clinical colleagues. Reorganization of workflow reduced turn-around times for PMD reports from a median of 33 days to 15 days. Short-term analysis revealed that this combined effort leads to a slight increase in the number of adult postmortal examinations 1 year after the introduction of this project. A change of culture in postmortal diagnostics may contribute to a better reputation of postmortal examinations from the perspective of clinicians, the general public, and affected relatives of the deceased. It may also serve to demonstrate that the pathology community is keen not only to preserve but also to further develop this valuable tool for medical quality control and education.

https://ift.tt/2B4i1Hr

An unusual presentation of metastatic malignant melanoma causing jejuno-jejunal intussusception: a case report

Small bowel intussusception in adults is rarely encountered. In most cases small bowel intussusception is caused by benign neoplastic lesions, but metastasis of cutaneous malignant melanoma causing small bowel...

https://ift.tt/2FiN32f

15q23 Gain in a Neonate with a Giant Omphalocele and Multiple Co-Occurring Anomalies

Background. Omphalocele is a rare congenital abdominal wall defect. It is frequently associated with genetic abnormality and other congenital anomalies, although isolated omphalocele cases do exist. Data have shown that omphalocele with co-occurring genetic abnormality has worse prognosis than isolated omphalocele. Chromosomal analysis by a conventional technique such as karyotyping can only detect aneuploidy and large segmental duplication or deletion. Newer techniques such as high-resolution microarray analysis allow for the study of alterations in chromosomal segments that are less than 5 Mb in length; this has led to identification of critical region and genes in the pathogenesis of omphalocele. Case Presentation. The current study is the initial report of a newborn male with a 15q23 gain and a giant omphalocele. High-resolution chromosomal microarray analysis identified this gain of copy number spanned 676 kb, involving almost the entire NOX5 gene (except for exon 1 of the longer transcript), the entirety of the EWSAT1, GLCE, PAQR5, KIF23, RPLP1, and DRAIC genes and exons 1–3 of the PCAT29 gene. Conclusion. To date, this is the first report of an associated 15q23 gain in a case with omphalocele. Interestingly, Giancarlo Ghiselli and Steven A Farber have reported that GLCE knockdown impairs abdominal wall closure in zebrafish. We also identified GLCE gene alteration in our case. This highlights the importance of GLCE in abdominal wall development. Further study of the function of GLCE and other genes might lead to a better understanding of the molecular mechanism of omphalocele.

https://ift.tt/2z9Enpl

Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART

Derache, A; Iwuji, CC; Danaviah, S; Giandhari, J; Marcelin, A-G; Calvez, V; de Oliveira, T; ... Gupta, RK; + view all Derache, A; Iwuji, CC; Danaviah, S; Giandhari, J; Marcelin, A-G; Calvez, V; de Oliveira, T; Dabis, F; Pillay, D; Gupta, RK; - view fewer (2018) Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART. Journal of Antimicrobial Chemotherapy 10.1093/jac/dky428 . Green open access

https://ift.tt/2FiRUjP

Capturing Real-Time Public Space Activity Using Publicly Available Digital Traces

Cheliotis, K; (2016) Capturing Real-Time Public Space Activity Using Publicly Available Digital Traces. In: Quercia, D and Pelechrinis, K, (eds.) Proceedings of the Tenth International AAAI Conference on Web and Social Media. AAAI Press: Cologne, Germany.

https://ift.tt/2qRhClL

MARVEL Analysis of the Measured High-resolution Rovibronic Spectra of (ZrO)-Zr-90-O-16

McKemmish, LK; Borsovszky, J; Goodhew, KL; Sheppard, S; Bennett, AFV; Martin, ADJ; Singh, A; ... Tennyson, J; + view all McKemmish, LK; Borsovszky, J; Goodhew, KL; Sheppard, S; Bennett, AFV; Martin, ADJ; Singh, A; Sturgeon, CAJ; Furtenbacher, T; Csaszar, AG; Tennyson, J; - view fewer (2018) MARVEL Analysis of the Measured High-resolution Rovibronic Spectra of (ZrO)-Zr-90-O-16. The Astrophysical Journal , 867 (1) , Article 33. 10.3847/1538-4357/aadd19 . Green open access

https://ift.tt/2FiIG7l

Measurement of colour flow using jet-pull observables in in t(t)over-bar events with the ATLAS experiment at root s=13TeV

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... Zwalinski, L; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Akesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Gonzalez, BA; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Coutinho, YA; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, DJA; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Ferraz, VA; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Armbruster, AJ; Armitage, LJ; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkin, RJ; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Bagnaia, P; Bahmani, M; Bahrasemani, H; Baines, JT; Bajic, M; Baker, OK; Bakker, PJ; Gupta, DB; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Banas, E; Bandyopadhyay, A; Banerjee, S; Bannoura, AAE; Barak, L; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barkeloo, J; Barklow, T; Barlow, N; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Barranco Navarro, L; Barreiro, F; Barreiro Guimaraes da Costa, J; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bauer, KT; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, P; Beck, HC; Beck, HP; Becker, K; Becker, M; Becot, C; Beddall, A; Beddall, AJ; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Bergsten, LJ; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertram, IA; Bertsche, C; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bianchi, RM; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, NV; Biglietti, M; Billoud, TRV; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, DM; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blumenschein, U; Blunier, D; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Bock, C; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Bonilla, JS; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Bossio Sola, JD; Boudreau, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bozson, AJ; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Braren, F; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Briglin, DL; Bristow, TM; Britton, D; Britzger, D; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brost, E; Broughton, JH; Bruckman de Renstrom, PA; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Bugge, MK; Buehrer, F; Bulekov, O; Bullock, D; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Buescher, D; Buescher, V; Buschmann, E; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabrera Urban, S; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Lopez, SC; Calvet, D; Calvet, S; Calvet, TP; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Cano Bret, M; Cantero, J; Cao, T; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, FC; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Casadei, D; Casado, MP; Casha, AF; Casolino, M; Casper, DW; Castelijn, R; Castillo Gimenez, V; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, CH; Chen, H; Chen, J; Chen, J; Chen, S; Chen, SJ; Chen, X; Chen, Y; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; Cherkaoui El Moursli, R; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Cinca, D; Cindro, V; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Clark, A; Clark, MR; Clark, PJ; Clarke, RN; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Conde Muino, P; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conti, G; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corrigan, EE; Corriveau, F; Cortes-Gonzalez, A; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Cummings, J; Curatolo, M; Cuth, J; Czekierda, S; Czodrowski, P; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dahbi, S; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; D'amen, G; Dandoy, JR; Daneri, MF; Dang, NP; Dann, ND; Danninger, M; Hoffmann, MD; Dao, V; Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; D'Auria, S; Davey, W; David, C; Davidek, T; Davis, DR; Davison, P; Dawe, E; Dawson, I; De, K; De Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; DeRegie, JBDV; Debenedetti, C; Dedovich, DV; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Della Pietra, M; Della Volpe, D; Dell'Acqua, A; Dell'Asta, L; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Denisov, SP; Denysiuk, D; D'Eramo, L; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Diaz, MA; Dickinson, J; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, JI; DoVale, MAB; Dobre, M; Dodsworth, D; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Donini, J; D'Onofrio, M; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dreyer, E; Dris, M; Du, Y; Duarte-Campderros, J; Dubinin, F; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duehrssen, M; Duelsen, C; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Duperrin, A; DuranYildiz, H; Dueren, M; Durglishvili, A; Duschinger, D; Dutta, B; Duvnjak, D; Dyndal, M; Dziedzic, BS; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Ellinghaus, F; Elliot, AA; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Ennis, JS; Epland, MB; Erdmann, J; Ereditato, A; Errede, S; Escalier, M; Escobar, C; Esposito, B; EstradaPastor, O; Etienvre, AI; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Fabiani, V; Facini, G; Fakhrutdinov, RM; Falciano, S; Falla, RJ; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feickert, M; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, H; Fenton, MJ; Fenyuk, AB; Feremenga, L; Fernandez Martinez, P; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filthaut, F; Fincke-Keeler, M; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, C; Fischer, J; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Flores, LM; Flores Castillo, LR; Fomin, N; Forcolin, GT; Formica, A; Foerster, FA; Forti, AC; Foster, AG; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franconi, L; 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Guo, W; Guo, Y; Gupta, R; Gurbuz, S; Gustavino, G; Gutelman, BJ; Gutierrez, P; Ortiz, NGG; Gutschow, C; Guyot, C; Guzik, MP; Gwenlan, C; Gwilliam, CB; Haas, A; Haber, C; Hadavand, HK; Haddad, N; Hadef, A; Hageboeck, S; Hagihara, M; Hakobyan, H; Haleem, M; Haley, J; Halladjian, G; Hallewell, GD; Hamacher, K; Hamal, P; Hamano, K; Hamilton, A; Hamity, GN; Han, K; Han, L; Han, S; Hanagaki, K; Hance, M; Handl, DM; Haney, B; Hankache, R; Hanke, P; Hansen, E; Hansen, JB; Hansen, JD; Hansen, MC; Hansen, PH; Hara, K; Hard, AS; Harenberg, T; Hariri, F; Harkusha, S; Harrison, PF; Hartmann, NM; Hasegawa, Y; Hasib, A; Hassani, S; Haug, S; Hauser, R; Hauswald, L; Havener, LB; Havranek, M; Hawkes, CM; Hawkings, RJ; Hayden, D; Hays, CP; Hays, JM; Hayward, HS; Haywood, SJ; Heck, T; Hedberg, V; Heelan, L; Heer, S; Heidegger, KK; Heim, S; Heim, T; Heinemann, B; Heinrich, JJ; Heinrich, L; Heinz, C; Hejbal, J; Helary, L; Held, A; Hellman, S; Helsens, C; Henderson, RCW; Heng, Y; Henkelmann, S; Correia, AMH; Herbert, GH; Herde, H; Herget, V; Jimenez, YH; Herr, H; Herten, G; Hertenberger, R; Hervas, L; Herwig, TC; Hesketh, GG; Hessey, NP; Hetherly, JW; Higashino, S; Higon-Rodriguez, E; Hildebrand, K; Hill, E; Hill, JC; Hiller, KH; Hillier, SJ; Hils, M; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hlaluku, DR; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, MC; Hoecker, A; Hoeferkamp, MR; Hoenig, F; Hohn, D; Hohov, D; Holmes, TR; Holzbock, M; Homann, M; Honda, S; Honda, T; Hong, TM; Hooberman, BH; Hopkins, WH; Horii, Y; Horton, AJ; Hostachy, J-Y; Hostiuc, A; Hou, S; Hoummada, AA; Howarth, J; Hoya, J; Hrabovsky, M; Hrdinka, J; Hristova, I; Hrivnac, J; Hrynevich, A; Hryn'ova, T; Hsu, PJ; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huffman, TB; Hughes, EW; Huhtinen, M; Hunter, RFH; Huo, P; Hupe, AM; Huseynov, N; Huston, J; Huth, J; Hyneman, R; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Idrissi, Z; Iengo, P; Igonkina, O; Iguchi, R; Iizawa, T; Ikegami, Y; Ikeno, M; Iliadis, D; Ilic, N; Iltzsche, F; Introzzi, G; Iodice, M; Iordanidou, K; Ippolito, V; Isacson, MF; Ishijima, N; Ishino, M; Ishitsuka, M; Issever, C; Istin, S; Ito, F; Ponce, JMI; Iuppa, R; Iwasaki, H; Izen, JM; Izzo, V; Jabbar, S; Jackson, P; Jacobs, RM; Jain, V; Jaekel, G; Jakobi, KB; Jakobs, K; Jakobsen, S; Jakoubek, T; Jamin, DO; Jana, DK; Jansky, R; Janssen, J; Janus, M; Janus, PA; Jarlskog, G; Javadov, N; Javurek, T; Javurkova, M; Jeanneau, F; Jeanty, L; Jejelava, J; Jelinskas, A; Jenni, P; Jeske, C; Jezequel, S; Ji, H; Jia, J; Jiang, H; Jiang, Y; Jiang, Z; Jiggins, S; Pena, JJ; Jin, S; Jinaru, A; Jinnouchi, O; Jivan, H; Johansson, P; Johns, KA; Johnson, CA; Johnson, WJ; Jon-And, K; Jones, RWL; Jones, SD; Jones, S; Jones, TJ; Jongmanns, J; Jorge, PM; Jovicevic, J; Ju, X; Rozas, AJ; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kahn, SJ; Kaji, T; Kajomovitz, E; Kalderon, CW; Kaluza, A; Kama, S; Kamenshchikov, A; Kanjir, L; Kano, Y; Kantserov, VA; Kanzaki, J; Kaplan, B; 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The European Physical Journal C , 78 (10) , Article 847. 10.1140/epjc/s10052-018-6290-2 . Green open access

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