American Thyroid Association Guidelines and Statements: Past, Present, and Future

Thyroid, Ahead of Print.


https://ift.tt/2r3dU8g

Over- and Under-Treatment of Hypothyroidism Is Associated with Excess Mortality: A Register-Based Cohort Study

Thyroid, Ahead of Print.


https://ift.tt/2Hy1nEA

Preparation of the Secretory Recombinant ALV-J gp85 Protein Using Pichia pastoris and Its Immunoprotection as Vaccine Antigen Combining with CpG-ODN Adjuvant

Viral Immunology, Ahead of Print.


https://ift.tt/2r75vke

Cell Biology of T Cell Receptor Expression and Regulation

Annual Review of Immunology, Volume 36, Issue 1, Page 103-125, April 2018.


https://ift.tt/2HtVWGN

Immune Responses to Retroviruses

Annual Review of Immunology, Volume 36, Issue 1, Page 193-220, April 2018.


https://ift.tt/2r4bMNi

ZAP-70 in Signaling, Biology, and Disease

Annual Review of Immunology, Volume 36, Issue 1, Page 127-156, April 2018.


https://ift.tt/2HtsfWx

IgA Function in Relation to the Intestinal Microbiota

Annual Review of Immunology, Volume 36, Issue 1, Page 359-381, April 2018.


https://ift.tt/2r2AZrC

Apoptosis and Clearance of Apoptotic Cells

Annual Review of Immunology, Volume 36, Issue 1, Page 489-517, April 2018.


https://ift.tt/2HtVVCJ

Autophagy and Inflammation

Annual Review of Immunology, Volume 36, Issue 1, Page 73-101, April 2018.


https://ift.tt/2r4bLcc

Regulation of the Cell Biology of Antigen Cross-Presentation

Annual Review of Immunology, Volume 36, Issue 1, Page 717-753, April 2018.


https://ift.tt/2HtsctP

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

Annual Review of Immunology, Volume 36, Issue 1, Page 435-459, April 2018.


https://ift.tt/2r2PYSh

Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

Annual Review of Immunology, Volume 36, Issue 1, Page 157-191, April 2018.


https://ift.tt/2HtVSqx

Self-Reactive B Cells in the Germinal Center Reaction

Annual Review of Immunology, Volume 36, Issue 1, Page 339-357, April 2018.


https://ift.tt/2r3hvmt

Immune Responses in the Liver

Annual Review of Immunology, Volume 36, Issue 1, Page 247-277, April 2018.


https://ift.tt/2HuusRt

The Formation and Function of Granulomas

Annual Review of Immunology, Volume 36, Issue 1, Page 639-665, April 2018.


https://ift.tt/2r4fbvt

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons

Annual Review of Immunology, Volume 36, Issue 1, Page 603-638, April 2018.


https://ift.tt/2HvTUpN

Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis

Annual Review of Immunology, Volume 36, Issue 1, Page 43-71, April 2018.


https://ift.tt/2r4bFkQ

Genetics of Natural Killer Cells in Human Health, Disease, and Survival

Annual Review of Immunology, Volume 36, Issue 1, Page 519-548, April 2018.


https://ift.tt/2HtCXw6

Evolution of Alternative Adaptive Immune Systems in Vertebrates

Annual Review of Immunology, Volume 36, Issue 1, Page 19-42, April 2018.


https://ift.tt/2r4bCFG

Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation

Annual Review of Immunology, Volume 36, Issue 1, Page 221-246, April 2018.


https://ift.tt/2Hu3nOk

Rebooting Human Immunology

Annual Review of Immunology, Volume 36, Issue 1, Page 843-864, April 2018.


https://ift.tt/2r4bBBC

Exploiting Nanobodies’ Singular Traits

Annual Review of Immunology, Volume 36, Issue 1, Page 695-715, April 2018.


https://ift.tt/2HsjU5g

Immune Response to Dengue and Zika

Annual Review of Immunology, Volume 36, Issue 1, Page 279-308, April 2018.


https://ift.tt/2r3Iqil

Antibody-based vaccine strategies against intracellular pathogens

Arturo Casadevall

https://ift.tt/2vSxdGU

Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis

Jan Kazenwadel | Natasha L Harvey

https://ift.tt/2vSxd9S

Involvement of ion channels in allergy

Lucette Pelletier | Magali Savignac

https://ift.tt/2r45FZm

Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis

Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the ...

https://ift.tt/2HPvZ3U

High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma

Advances in high throughput technologies and big data analytics are rapidly increasing our understanding of the role of various immune cells and factors associated with atopic disease beyond the Th1/Th2 axis. Many children and adults with atopy can suffer from co-morbid conditions like having food allergy and chronic asthma, which can increase the risk of anaphylaxis and fatal reactions to a food allergen. Further understanding of the contributions and roles of the different immune cell subsets would be of great value in understanding the food allergy-asthma co-morbid clinical phenotype.

https://ift.tt/2I2lrMl

From the pages of allergywatch June 2018

Allergic contact dermatitis (ACD) is a common condition in children, and may become a recurrent and chronic problem. Patch testing is the standard for diagnosis of ACD. The authors review their center's 10-year experience with pediatric patch testing. From 2005 to 2015, 157 children and adolescents underwent patch testing at the authors' dermatology department. Test procedures followed North American Contact Dermatitis Group standards. The median patient age was 13 years; 58.6% were female. Symptoms were present for 6 months to 2 years in about one-third of patients, and longer than 2 years in nearly half.

https://ift.tt/2FkeFyS

Characteristics of tinnitus found in anemia patients and analysis of population-based survey

This study analyzed the characteristics of tinnitus identified in anemia patients with cohort- and population-based studies in a single institute and suggests a management algorithm.

https://ift.tt/2HRkoS1

Inside EMS Podcast: Is intubation dead in EMS?

Download this podcast on iTunes, SoundCloud or via RSS feed In this Inside EMS Podcast episode, co-hosts Chris Cebollero and Kelly Grayson discuss the practice of airway management. Is intubation dead in EMS, and have we entered the world of supraglottic airways" Let us know your thoughts in the comment section below. Learn more about the EMS1 Academy and schedule a free demo.

https://ift.tt/2r2stcc

How To Prevent Tick Diseases

Spring has arrived and we are all excited to get outdoors and enjoy the weather. However, through all the excitement it's important to help keep your family safe from tick diseases. This is quite the challenge but here is our best advice on preventing tick bites all together.

The post How To Prevent Tick Diseases appeared first on ChildrensMD.

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Have Laryngologists Found One More Disease to Treat With a Flexible Laryngoscope and a Needle?—Reply

In Reply We thank Dr Bradley for his commentary regarding our recently published article, "Serial In-Office Intralesional Steroid Injections in Airway Stenosis." We agree with his comment highlighting how advances in one discipline can forward another, and that the treatment of scarring has been well studied. Applying proven treatments for scarring in other locations of the body is prudent, and we foresee the application of a number of newer treatments for scarring (ie, flourourocil) in airway stenosis. We acknowledge the lack of a true control group in this particular study. In addition, we appreciate that it is not clear how many total injections are required to effect positive changes for any given patient. With future evaluation of a larger cohort, we anticipate elucidating this more clearly and will likely be able to target different etiologic subgroups more specifically. Recognizing that intralesional steroid injections for airway stenosis will not be a panacea, patients with different etiologies of subglottic stenosis will need to be treated slightly differently, tailoring treatment to the patient's disease. We use intralesional steroid injections largely in 3 different ways. The first is as an adjuvant after an endoscopic procedure; this is done for patients in all etiologic subgroups. For patients in the traumatic subgroup for whom intralesional steroid injection is effective (ie, without significant cartilage collapse), ongoing intervention may not be required because they do not have a relapsing disorder. On the other hand, patients with inflammatory causes of stenosis, who have a high chance of recurrence, can benefit from adjuvant injections after surgery as well as maintenance injections for early recurrence. Recent reports aimed at identifying the etiology of idiopathic subglottic stenosis (iSGS), have suggested a local, inflammatory, immune response. The early stage of recurrence in both iSGS and rheumatologic-types of stenosis is granulation and erythema in the subglottis, followed by healing with fibrosis. Intervention with intralesional steroid injections (or potentially another immune modulator) at this early stage may alter wound healing, avoid scar formation, and therefore circumvent the need for surgical intervention. Several studies have shown efficacy, safety, and tolerance in patients with iSGS in addition to reducing the need for surgical treatment. Last, as previously observed, we have seen steroid injections dissolve scar tissue that has already formed, therefore obviating the need for surgical intervention in some patients when presenting without critical stenosis. Investigating alternative treatments for scarring is relevant in subglottic stenosis, but we also suggest exploring ways to pharmacologically modulate the inflammatory phase of the disease.

https://ift.tt/2r1hj8c

Extending the Ear-Kidney Association to Presbycusis

Understanding the causes of presbycusis is a major goal of health research because it is such a common human condition. The ear-kidney association has been known at least since the early 20th century, when the Alport and branchio-oto-renal syndromes were described. It was also noted that the cochlea and kidney share the presence of pericytes and podocytes in the glomeruli and inner ear, indicating similarities in microcirculation. The ear and kidney have in common some forms of organ-specific toxic effects (eg, due to treatment with aminoglycosides or cisplatin), and both organs are actively engaged in ion transport functions to maintain homeostasis. On the other hand, there has been little evidence that the ear-kidney association might be important in presbycusis.

https://ift.tt/2vRqcpG

Hearing Aid Use and Health Care Costs Among Older Adults

A number of studies have attempted to quantify the cost of hearing loss, including ones using the same data source but an earlier time. A systematic review that summarized many of these findings documented the financial results of hearing loss, but also highlighted the variability across studies and lack of standardization of how hearing loss is defined when using large data sets. Fewer data are available, however, on whether the use of hearing aids (HAs) mitigates, attenuates, or contributes to these costs. Given the lack of data, the increasing numbers of older adults who might benefit from the use of HAs and the current lack of health care coverage for hearing health care, Mahmoudi et al is exploring an important topic in this issue of JAMA Otolaryngology–Head and Neck Surgery. Elucidating the outcomes of HA use on health care costs could provide valuable data for those designing health care policy. The findings are interesting, yet raise a number of issues that could inform data interpretation as well as highlight additional research priorities.

https://ift.tt/2r0vJVY

Have Laryngologists Found One More Disease to Treat With a Flexible Laryngoscope and a Needle?

To the Editor "Learning and innovation go hand in hand. The arrogance of success is to think that what you did yesterday will be sufficient for tomorrow."—William Pollard

https://ift.tt/2vOVq0H

Cystatin C and 20-Year Incidence of Hearing Impairment

This longitudinal, population-based study uses data from the Epidemiology of Hearing Loss Study to investigate the association between cystatin C, both as an independent biomarker and as a marker of kidney function, and the 20-year incidence of hearing impairment in a cohort of middle-aged and older adults.

https://ift.tt/2r7A4XR

Hearing Aid Use and Health Care Use and Cost Among Older Adults With Hearing Loss

This population-based cohort study of older adults with hearing loss evaluates the association of hearing aid use and health care use and cost.

https://ift.tt/2vL8zru

Effect of Perioperative Gabapentin Use in Patients Undergoing Head and Neck Mucosal Surgery

This randomized clinical trial investigates the effect of perioperative gabapentin treatment vs placebo on postsurgical pain in patients undergoing head and neck mucosal surgery.

https://ift.tt/2Jvopst

Severe caries are a clue for child neglect: a case report

Child abuse and neglect have strong negative effects on the well-being of children, not only during childhood but also later in life. Therefore, early recognition is important.

https://ift.tt/2FmPZWw

The importance of endoscopic ultrasound fine-needle aspiration in the diagnosis of solid pseudopapillary tumor of the pancreas: two case reports

Solid pseudopapillary tumor of the pancreas, otherwise known as solid and cystic tumor or Frantz tumor, is an unusual form of pancreatic carcinoma, with unknown etiopathogenesis, that accounts for 0.2 to 2.7% ...

https://ift.tt/2I1xRUQ

Data Literacy in der Medizin

Zusammenfassung

Hintergrund

Die digitale Transformation des Gesundheitssystems verändert den Beruf des Arztes. Data Literacy wird hierbei als eine der führenden Zukunftskompetenzen erachtet, findet jedoch derzeit weder in den implementierten Curricula des Medizinstudiums noch in den aktuell laufenden Reformprozessen (Masterplan Medizinstudium 2020 und Nationaler Kompetenzbasierter Lernzielkatalog) Beachtung.

Ziel

Der Beitrag möchte zum einen die Aspekte beleuchten, die im Begriff der Data Literacy im medizinischen Kontext gebündelt werden. Zum andern wird ein Lehrkonzept vorgestellt, das Data Literacy im Zeichen der digitalen Transformation erstmals im Medizinstudium abbildet.

Material und Methoden

Das Blended-Learning-Curriculum „Medizin im digitalen Zeitalter" adressiert in 5 Modulen den diversen Transformationsprozess der Medizin von digitaler Kommunikation über Smart Devices und medizinische Apps, Telemedizin, virtuelle/augmentierte und robotische Chirurgie bis hin zu individualisierter Medizin und Big Data. Diese Arbeit stellt Konzept und Erfahrungen der erstmaligen Implementierung des 5. Moduls dar, welches transdisziplinär und integrativ den Aspekt Data Literacy erläutert.

Ergebnisse

Die Evaluation des Kurskonzepts erfolgte sowohl qualitativ als auch quantitativ und demonstriert einen Kompetenzgewinn in den Bereichen Wissen und Fertigkeiten sowie eine differenziertere Haltung nach Kursabschluss.

Schlussfolgerungen

Die curriculare Integration von Data Literacy ist eine transdisziplinäre und longitudinale Aufgabe. Bei der Entwicklung dieser Curricula sollten die hohe Geschwindigkeit des Veränderungsprozesses der digitalen Transformation beachtet und die curriculare Anpassung im Sinne eines Agility by Design bereits bei der Konzeption adressiert werden.

https://ift.tt/2vTsTas

E-Health-Angebote in der Onkologie

Zusammenfassung

Hintergrund

Die krankheits- und behandlungsbedingten Belastungen von Krebserkrankungen gehen in der Regel mit deutlichen Beeinträchtigungen der Lebensqualität der Betroffenen einher. Durch die starke Verbreitung des Internets in deutschen Haushalten stellen onkologische E‑Health-Angebote eine schnelle und einfach zugängliche mögliche Quelle der Unterstützung für Patienten und Angehörige dar. Angebote für Behandler umfassen z. B. Informationsportale, die Behandler auf die Bedürfnisse von Krebspatienten vorbereiten. Die Zukunft von onkologischen E‑Health Angeboten scheint in der Entwicklung von Angeboten für das Smartphone zu liegen.

Ziel

Die Autoren beschreiben E‑Health-Angebote in der Onkologie, v. a. hinsichtlich Form und Inhalt, Inanspruchnahme und Wirksamkeit.

Diskussion/Schlussfolgerung

In der Literatur ist eine große Anzahl von Studien zu finden, die Prozess und Outcome von E‑Health-Interventionen evaluieren. Jedoch wird weiterhin ein Bedarf für gut designte höherwertige RCTs (randomisierte kontrollierte Studien) konstatiert, unter anderem um genauere Aussagen zur Wirksamkeit der Angebote treffen zu können. Häufig berichtete Probleme der E‑Health-Angebote sind hohe Dropout-Raten und ein Nachhohlbedarf bei der bisher weitgehend fehlenden Implementierung der in Studien erprobten Ansätze in die Versorgungspraxis. Das Einbeziehen von potenziellen Zielgruppen in den Entwicklungsprozess der Angebote könnte hilfreich sein, um das Auftreten von hohen Dropout-Raten und Usability-Problemen zu vermindern und sicherzustellen, dass die Angebote dem Bedarf der Patienten entsprechen.

https://ift.tt/2HQKGDL

Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature

Abstract

Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Skin lesions are present for an average of > 6 years before oral involvement occurs. The clinical appearance is highly variable with tongue, palate and gingiva most often affected. We report 3 additional cases of oral MF, including one in which oral lesions are the initial disease presentation. Survival in patients presenting with oral MF is improving and can be attributed to advances in therapy.

https://ift.tt/2vUqzjc

Action Sounds Modulate Arm Reaching Movements (vol 7, 1391, 2016)

Tajadura-Jimenez, A; Marquardt, T; Swapp, D; Kitagawa, N; Bianchi-Berthouze, N; (2016) Action Sounds Modulate Arm Reaching Movements (vol 7, 1391, 2016). [Corrigendum]. Front. Psychol. , 7 , Article 1878. 10.3389/fpsyg.2016.01878 . Green open access

https://ift.tt/2r2xXn1

Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome

Li, C; Lenhard, B; Luscombe, NM; (2018) Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome. Genome Research 10.1101/gr.231449.117 . (In press). Green open access

https://ift.tt/2HtuJE7

Upward-pointing cosmic-ray-like events observed with ANITA

Romero-Wolf, A; Gorham, PW; Nam, J; Hoover, S; Allison, P; Banerjee, O; Batten, L; ... Zas, E; + view all Romero-Wolf, A; Gorham, PW; Nam, J; Hoover, S; Allison, P; Banerjee, O; Batten, L; Beatty, JJ; Belov, K; Besson, DZ; Binns, WR; Bugaev, V; Cao, P; Chen, C; Chen, P; Clem, JM; Connolly, A; Dailey, B; Deaconu, C; Cremonesi, L; Dowkontt, PF; DuVernois, MA; Field, RC; Fox, BD; Goldstein, D; Gordon, J; Hast, C; Hebert, CL; Hill, B; Hughes, K; Hupe, R; Israel, MH; Javaid, A; Kowalski, J; Lam, J; Ludwig, A; Learned, JG; Liewer, KM; Liu, TC; Link, JT; Lusczek, E; Matsuno, S; Mercurio, BC; Miki, C; Miočinović, P; Mottram, M; Mulrey, K; Naudet, CJ; Ng, J; Nichol, RJ; Novikov, A; Palladino, K; Prohira, S; Rauch, BF; Reil, K; Roberts, J; Rosen, M; Rotter, B; Russell, J; Ruckman, L; Saltzberg, D; Seckel, D; Stafford, S; Stockham, J; Stockham, M; Strutt, B; Tatem, K; Varner, GS; Vieregg, AG; Walz, D; Wissel, SA; Wu, F; Alvarez-Muñiz, J; Carvalho, W; Schoorlemmer, H; Zas, E; - view fewer (2017) Upward-pointing cosmic-ray-like events observed with ANITA. In: 35th International Cosmic Ray Conference (ICRC2017) - Session Neutrino. NU-astrophysical neutrinos, Volume 301. PoS - Proceedings of Science: Buscan, Korea. Green open access

https://ift.tt/2r2xJwb

Framing the challenge of climate change in Nature and Science editorials

Hulme, M; Obermeister, N; Randalls, S; Borie, M; (2018) Framing the challenge of climate change in Nature and Science editorials. Nature Climate Change (In press).

https://ift.tt/2HuawOu

Stem Cell Interventions for Bone Healing: Fractures and Osteoporosis

Sanghani-Kerai, A; McCreary, D; Lancashire, H; Osagie, L; Coathup, M; Blunn, G; (2018) Stem Cell Interventions for Bone Healing: Fractures and Osteoporosis. Current Stem Cell Research & Therapy , 13 10.2174/1574888X13666180410160511 . (In press).

https://ift.tt/2r00YzG

Do private school girls marry rich?

Green, F; Henseke, G; Parsons, S; Sullivan, A; Wiggins, R; (2019) Do private school girls marry rich? Longitudinal and Life Course Studies (In press).

https://ift.tt/2HxRnvq

Strain-Induced Spin-Resonance Shifts in Silicon Devices

Pla, JJ; Bienfait, A; Pica, G; Mansir, J; Mohiyaddin, FA; Zeng, Z; Niquet, YM; ... Bertet, P; + view all Pla, JJ; Bienfait, A; Pica, G; Mansir, J; Mohiyaddin, FA; Zeng, Z; Niquet, YM; Morello, A; Schenkel, T; Morton, JJL; Bertet, P; - view fewer (2018) Strain-Induced Spin-Resonance Shifts in Silicon Devices. Phys. Rev. Applied , 9 (4) , Article 044014. 10.1103/PhysRevApplied.9.044014 . Green open access

https://ift.tt/2r2xmlh

Photobiomodulation reduces gliosis in the basal ganglia of aged mice

El Massri, N; Weinrich, TW; Kam, JH; Jeffery, G; Mitrofanis, J; (2018) Photobiomodulation reduces gliosis in the basal ganglia of aged mice. Neurobiology of Aging , 66 pp. 131-137. 10.1016/j.neurobiolaging.2018.02.019 . Green open access

https://ift.tt/2Huq5WD

Asmara: Africa’s Modernist City (UNESCO World Heritage Nomination)

Denison, E; Teklemariam, M; Abraha, D; (2017) Asmara: Africa's Modernist City (UNESCO World Heritage Nomination). The Journal of Architecture , 22 (1) pp. 11-53. 10.1080/13602365.2016.1276093 .

https://ift.tt/2r5pEam

Golden RAtio Stack of Spirals for flexible angiographic imaging: proof of concept in congenital heart disease

Kowalik, G; Steeden, J; Atkinson, D; Montalt-Tordera, J; Mortenson, K; Muthurangu, V; (2019) Golden RAtio Stack of Spirals for flexible angiographic imaging: proof of concept in congenital heart disease. Magnetic Resonance in Medicine 10.1002/mrm.27353 . (In press).

https://ift.tt/2HtbU46

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

Barzaghi, F; Hernandez, LCA; Neven, B; Ricci, S; Kucuk, ZY; Bleesing, JJ; Nademi, Z; ... Bacchetta, R; + view all Barzaghi, F; Hernandez, LCA; Neven, B; Ricci, S; Kucuk, ZY; Bleesing, JJ; Nademi, Z; Slatter, MA; Ulloa, ER; Shcherbina, A; Roppelt, A; Worth, A; Silva, J; Aiuti, A; Murguia-Favela, L; Speckmann, C; Carneiro-Sampaio, M; Fernandes, JF; Baris, S; Ozen, A; Karakoc-Aydiner, E; Kiykim, A; Schulz, A; Steinmann, S; Notarangelo, LD; Gambineri, E; Lionetti, P; Shearer, WT; Forbes, LR; Martinez, C; Moshous, D; Blanche, S; Fisher, A; Ruemmele, FM; Tissandier, C; Ouachee-Chardin, M; Rieux-Laucat, F; Cavazzana, M; Qasim, W; Lucarelli, B; Albert, MH; Kobayashi, I; Alonso, L; De Heredia, CD; Kanegane, H; Lawitschka, A; Seo, JJ; Gonzalez-Vicent, M; Diaz, MA; Goyal, RK; Sauer, MG; Yesilipek, A; Kim, M; Yilmaz-Demirdag, Y; Bhatia, M; Khlevner, J; Padilla, EJR; Martino, S; Montin, D; Neth, O; Molinos-Quintana, A; Valverde-Fernandez, J; Broides, A; Pinsk, V; Ballauf, A; Haerynck, F; Bordon, V; Dhooge, C; Garcia-Lloret, ML; Bredius, RG; Kawak, K; Haddad, E; Seidel, MG; Duckers, G; Pai, S-Y; Dvorak, CC; Ehl, S; Locatelli, F; Goldman, F; Gennery, AR; Cowan, MJ; Roncarolo, M-G; Bacchetta, R; - view fewer (2018) Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study. Journal of Allergy and Clinical Immunology , 141 (3) 1036-1049.e5. 10.1016/j.jaci.2017.10.041 . Green open access

https://ift.tt/2r1t65A

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Peeters, SA; Engelen, L; Buijs, J; Chaturvedi, N; Fuller, JH; Jorsal, A; Parving, H-H; ... Stehouwer, CDA; + view all Peeters, SA; Engelen, L; Buijs, J; Chaturvedi, N; Fuller, JH; Jorsal, A; Parving, H-H; Tarnow, L; Theilade, S; Rossing, P; Schalkwijk, CG; Stehouwer, CDA; - view fewer (2017) Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies. Cardiovascular Diabetology , 16 , Article 139. 10.1186/s12933-017-0620-9 . Green open access

https://ift.tt/2HtbI4S

Evidence for the associated production of the Higgs boson and a top quark pair with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... Zwalinski, L; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahlen, SP; Ahmadov, F; Aielli, G; Akatsuka, S; Akesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, SC; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Gonzalez, BA; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, DJ; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Ferraz, VA; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Armbruster, AJ; Armitage, LJ; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkin, RJ; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Avramidou, R; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Bagnaia, P; Bahmani, M; Bahrasemani, H; Baines, JT; Bajic, M; Baker, OK; Bakker, PJ; Gupta, DB; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Banas, E; Bandyopadhyay, A; Banerjee, S; Bannoura, AAE; Barak, L; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barkeloo, JT; Barklow, T; Barlow, N; Barnea, R; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Barranco Navarro, L; Barreiro, F; da Costa, JBG; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bauer, KT; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, P; Beck, HP; Beck, HC; Becker, K; Becker, M; Becot, C; Beddall, AJ; Beddall, A; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behera, A; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Bergsten, LJ; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertram, IA; Bertsche, C; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bianchi, RM; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, NV; Biglietti, M; Billoud, TRV; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, DM; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blumenschein, U; Blunier, D; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Bock, C; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Bonilla, JS; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Sola, JDB; Boudreau, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bozson, AJ; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Braren, F; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Briglin, DL; Bristow, TM; Britton, D; Britzger, D; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, F; Bugge, MK; Bulekov, O; Bullock, D; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Buescher, D; Buescher, V; Buschmann, E; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabras, G; Cabrera Urban, S; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Calvente Lopez, S; Calvet, D; Calvet, S; Calvet, TP; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Bret, MC; Cantero, J; Cao, T; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Casadei, D; Casado, MP; Casha, AF; Casolino, M; Casper, DW; Castelijn, R; Castillo Gimenez, V; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, C; Chen, H; Chen, J; Chen, J; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; Cherkaoui El Moursli, R; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Cinca, D; Cindro, V; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Clark, A; Clark, MR; Clark, PJ; Clarke, RN; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Conde Muino, P; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conti, G; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corrigan, EE; Corriveau, F; Cortes-Gonzalez, A; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Cummings, J; Curatolo, M; Cuth, J; Czekierda, S; Czodrowski, P; D'amen, G; D'Auria, S; D'eramo, L; D'Onofrio, M; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dahbi, S; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Dandoy, JR; Daneri, MF; Dang, NP; Dann, NS; Danninger, M; Hoffmann, MD; Dao, V; Darbo, G; Darmora, S; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davis, DR; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Debenedetti, C; Dedovich, DV; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Dell'Acqua, A; Dell'Asta, L; Della Pietra, M; della Volpe, D; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Denisov, SP; Denysiuk, D; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Diaz, MA; Dickinson, J; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, JI; do Vale, MAB; Dobre, M; Dodsworth, D; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Donini, J; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dreyer, E; Dris, M; Du, Y; Duarte-Campderros, J; Dubinin, F; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duhrssen, M; Dulsen, C; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Duperrin, A; Yildiz, HD; Dueren, M; Durglishvili, A; Duschinger, D; Dutta, B; Duvnjak, D; Dyndal, M; Dziedzic, BS; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Ellinghaus, F; Elliot, AA; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Ennis, JS; Epland, MB; Erdmann, J; Ereditato, A; Errede, S; Escalier, M; Escobar, C; Esposito, B; Estrada Pastor, O; Etienvre, AI; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Fabiani, V; Facini, G; Fakhrutdinov, RM; Falciano, S; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feickert, M; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, M; Fenton, MJ; Fenyuk, AB; Feremenga, L; Fernandez Martinez, P; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filthaut, F; Fincke-Keeler, M; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, C; Fischer, J; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Flores, LM; Castillo, LRF; Fomin, N; Forcolin, GT; Formica, A; Forster, FA; Forti, A; Foster, AG; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franconi, L; 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Watts, G; Watts, S; Waugh, BM; Webb, AF; Webb, S; Weber, MS; Weber, SM; Weber, SA; Webster, JS; Weidberg, AR; Weinert, B; Weingarten, J; Weirich, M; Weiser, C; Wells, PS; Wenaus, T; Wengler, T; Wenig, S; Wermes, N; Werner, MD; Werner, P; Wessels, M; Weston, TD; Whalen, K; Whallon, NL; Wharton, AM; White, AS; White, A; White, MJ; White, R; Whiteson, D; Whitmore, BW; Wickens, FJ; Wiedenmann, W; Wielers, M; Wiglesworth, C; Wiik-Fuchs, LAM; Wildauer, A; Wilk, F; Wilkens, HG; Williams, HH; Williams, S; Willis, C; Willocq, S; Wilson, JA; Wingerter-Seez, I; Winkels, E; Winklmeier, F; Winston, OJ; Winter, BT; Wittgen, M; Wobisch, M; Wolf, A; Wolf, TMH; Wolff, R; Wolter, MW; Wolters, H; Wong, VWS; Woods, NL; Worm, SD; Wosiek, BK; Wozniak, KW; Wu, M; Wu, SL; Wu, X; Wu, Y; Wyatt, TR; Wynne, BM; Xella, S; Xi, Z; Xia, L; Xu, D; Xu, L; Xu, T; Xu, W; Yabsley, B; Yacoob, S; Yajima, K; Yallup, DP; Yamaguchi, D; Yamaguchi, Y; Yamamoto, A; Yamanaka, T; Yamane, F; Yamatani, M; Yamazaki, T; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, S; Yang, Y; Yang, Z; Yao, W-M; Yap, YC; Yasu, Y; Yatsenko, E; YauWong, KH; Ye, J; Ye, S; Yeletskikh, I; Yigitbasi, E; Yildirim, E; Yorita, K; Yoshihara, K; Young, C; Young, CJS; Yu, J; Yu, J; Yuen, SPY; Yusuff, I; Zabinski, B; Zacharis, G; Zaidan, R; Zaitsev, AM; Zakharchuk, N; Zalieckas, J; Zambito, S; Zanzi, D; Zeitnitz, C; Zemaityte, G; Zeng, JC; Zeng, Q; Zenin, O; Zenis, T; Zerwas, D; Zhang, D; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, M; Zhou, M; Zhou, N; Zhou, Y; Zhu, CG; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zhulanov, V; Zibell, A; Zieminska, D; Zimine, NI; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Zivkovic, L; Zobernig, G; Zoccoli, A; Zou, R; zur Nedden, M; Zwalinski, L; - view fewer (2018) Evidence for the associated production of the Higgs boson and a top quark pair with the ATLAS detector. Physical Review D , 97 (7) , Article 072003. 10.1103/PhysRevD.97.072003 . Green open access

https://ift.tt/2r2Bq4X

The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites

Mittal, A; Hobor, F; Zhang, Y; Martin, SR; Gamblin, SJ; Ramos, A; Wilson, JR; (2018) The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites. Nucleic Acids Research , 46 (7) pp. 3802-3812. 10.1093/nar/gky199 . Green open access

https://ift.tt/2HswYaM

Orbitally forced hyperstratification of the Oligocene South Atlantic Ocean

Liebrand, D; Raffi, I; Fraguas, A; Laxenaire, R; Bosmans, J; Hilgens, F; Wilson, P; ... Sabia, L; + view all Liebrand, D; Raffi, I; Fraguas, A; Laxenaire, R; Bosmans, J; Hilgens, F; Wilson, P; Batenburg, S; Beddow, H; Bohaty, S; Bown, PR; Crocker, A; Huck, C; Lourens, L; Sabia, L; - view fewer (2018) Orbitally forced hyperstratification of the Oligocene South Atlantic Ocean. Paleoceanography and Paleoclimatology 10.1002/2017PA003222 . (In press).

https://ift.tt/2r1sInE

Sex Differences in the Clinical Outcomes of Oral Anticoagulants in Patients with Atrial Fibrillation

Law, S; Lau, WCY; Wong, ICK; Lip, GYH; Mok, MT; Siu, C-W; Chan, EW; (2018) Sex Differences in the Clinical Outcomes of Oral Anticoagulants in Patients with Atrial Fibrillation. Journal of the American College of Cardiology (In press).

https://ift.tt/2HswnWB

What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis

Vale, CL; Fisher, D; White, I; Carpenter, J; Burdett, S; Clarke, N; Fizazi, K; ... Tierney, J; + view all Vale, CL; Fisher, D; White, I; Carpenter, J; Burdett, S; Clarke, N; Fizazi, K; Gravis, G; James, N; Mason, M; Parmar, M; Rydzewska, L; Sweeney, C; Spears, M; Sydes, M; Tierney, J; - view fewer (2018) What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis. Annals of Oncology 10.1093/annonc/mdy071 . (In press). Green open access

https://ift.tt/2r2ATjt

First-line treatment of ovarian cancer: questions and controversies to address

Ledermann, JA; (2018) First-line treatment of ovarian cancer: questions and controversies to address. Therapeutic Advances in Medical Oncology , 10 pp. 1-8. 10.1177/1758835918768232 . Green open access

https://ift.tt/2Hsw5it

Uncovering inequality through multifractality of land prices: 1912 and contemporary Kyoto

Salat, HPP; Murcio Villanueva, R; Yano, K; Arcaute, E; (2018) Uncovering inequality through multifractality of land prices: 1912 and contemporary Kyoto. PLoS ONE 10.1371/journal.pone.0196737 . (In press).

https://ift.tt/2r35IVg

Neonatal care practices in sub-Saharan Africa: a systematic review of quantitative and qualitative data.

Bee, M; Shiroor, A; Hill, Z; (2018) Neonatal care practices in sub-Saharan Africa: a systematic review of quantitative and qualitative data. [Review]. J Health Popul Nutr , 37 (1) , Article 9. 10.1186/s41043-018-0141-5 . (In press). Green open access

https://ift.tt/2Ht00Hr

Mid-Life Chronic Inflammation May be Linked to Frailty Later

A study of nearly 6,000 Americans followed for 24 years from middle to late adulthood found that having chronic inflammation in middle age may be linked to an increased risk of frailty and overall poorer health decades later.

https://ift.tt/2r1KZC0

Response to “Immune-mediated cholangitis: is it always nivolumab’s fault?”

https://ift.tt/2r6SI23

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges

Abstract

The 8th edition of American Joint Committee on Cancer (AJCC 8th) staging manual incorporated depth of invasion (DOI) into pT stage of oral cavity cancer. The aim of this study was to characterize several histological findings that may complicate measurement of DOI in early conventional squamous cell carcinomas (SCC) of the oral tongue: (1) lack of or minimal residual carcinoma following biopsy; (2) positive deep margin; (3) extratumoral perineural invasion (PNI); and (4) lymphatic or vascular invasion. Conventional SCC of the oral tongue (n = 407) with the largest dimension of ≤ 4 cm and with a negative elective cervical lymph node dissection (pN0) were reviewed. A clear plastic ruler was used to measure DOI by dropping a "plumb line" to the deepest point of the invasive tumor from the level of the basement membrane of the normal mucosa closest to the invasive tumor. Examples of identifying  reference point on the mucosal surface of oral tongue from which to measure the DOI are illustrated. In the experience of one contributing institution, the residual carcinoma was absent in 14.2% of glossectomies (34/239), while in 4.8% of cases (10/205) there was only minimal residual carcinoma. In 11.5% (21/183) of pT2 cases the deep margin was positive and thus DOI and pT may be underestimated. Of all cases with PNI, extratumoral PNI was identified in 23.1% (31/134) of cases, but represented the deepest point of invasion in only two cases. In one case, lymphatic invasion represented the deepest point of invasion and could have led to upstaging from pT1 to pT2. In conclusion, DOI measurement for SCC of the oral tongue may require re-examination of the diagnostic biopsy in up to 20% of cases due to the absence or only minimal residual carcinoma in glossectomy specimens. In 11.5% of apparently pT2 cases, DOI may be underestimated due to the positive deep margin. Rarely, extratumoral PNI or lymphatic invasion may be the deepest point of invasion. Overall, two issues (absent or minimal residual disease and positive deep margin) may confound DOI measurement in early SCCs of oral tongue.

https://ift.tt/2r2mC7i

Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature

Abstract

Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Skin lesions are present for an average of > 6 years before oral involvement occurs. The clinical appearance is highly variable with tongue, palate and gingiva most often affected. We report 3 additional cases of oral MF, including one in which oral lesions are the initial disease presentation. Survival in patients presenting with oral MF is improving and can be attributed to advances in therapy.

https://ift.tt/2vUqzjc

Smartphone App Keeps an ‘Eye’ on Daily Tuberculosis Therapy

Johns Hopkins researchers report success with a
smart phone video-based app that substitutes for a daily in-person visit by a health care worker required for tuberculosis treatment known as directly observed therapy, or DOT. The preliminary study showed that the app may be less costly and may improve privacy concerns raised by patients compared to in-person visits.

https://ift.tt/2HYZkXa

Blind method regarding the effect of dexmedetomidine on CRBD

https://ift.tt/2Kiwx0z

Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors

Conditions:   Carcinoma, Squamous Cell of Head and Neck;   Carcinoma, Non-Small-Cell Lung;   Small Cell Lung Carcinoma
Interventions:   Drug: Durvalumab;   Drug: Tremelimumab;   Drug: Cisplatin (dose level 4);   Drug: Cisplatin (dose level 3);   Drug: Carboplatin (dose level 1);   Drug: Carboplatin (dose level 2);   Drug: Etoposide (dose level 1);   Drug: Etoposide (dose level 2);   Drug: Paclitaxel;   Drug: Pemetrexed;   Radiation: External beam radiation (dose level 1);   Radiation: External beam radiation (dose level 2);   Radiation: External beam radiation (hyperfractionated);   Drug: Cisplatin (dose level 1);   Drug: Cisplatin (dose level 2);   Radiation: External beam radiation (standard)
Sponsor:   AstraZeneca
Not yet recruiting

https://ift.tt/2JuoLj3

Case 13-2018: A 53-Year-Old Man with Cardiomyopathy and Recurrent Ventricular Tachycardia

Presentation of Case. Dr. Timothy W. Churchill: A 53-year-old man was admitted to this hospital because of shock and recurrent ventricular tachycardia after defibrillator placement for nonischemic cardiomyopathy. The patient had been in his usual state of health until 4 weeks before this admission,…

https://ift.tt/2HPlLRb

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges

Abstract

The 8th edition of American Joint Committee on Cancer (AJCC 8th) staging manual incorporated depth of invasion (DOI) into pT stage of oral cavity cancer. The aim of this study was to characterize several histological findings that may complicate measurement of DOI in early conventional squamous cell carcinomas (SCC) of the oral tongue: (1) lack of or minimal residual carcinoma following biopsy; (2) positive deep margin; (3) extratumoral perineural invasion (PNI); and (4) lymphatic or vascular invasion. Conventional SCC of the oral tongue (n = 407) with the largest dimension of ≤ 4 cm and with a negative elective cervical lymph node dissection (pN0) were reviewed. A clear plastic ruler was used to measure DOI by dropping a "plumb line" to the deepest point of the invasive tumor from the level of the basement membrane of the normal mucosa closest to the invasive tumor. Examples of identifying  reference point on the mucosal surface of oral tongue from which to measure the DOI are illustrated. In the experience of one contributing institution, the residual carcinoma was absent in 14.2% of glossectomies (34/239), while in 4.8% of cases (10/205) there was only minimal residual carcinoma. In 11.5% (21/183) of pT2 cases the deep margin was positive and thus DOI and pT may be underestimated. Of all cases with PNI, extratumoral PNI was identified in 23.1% (31/134) of cases, but represented the deepest point of invasion in only two cases. In one case, lymphatic invasion represented the deepest point of invasion and could have led to upstaging from pT1 to pT2. In conclusion, DOI measurement for SCC of the oral tongue may require re-examination of the diagnostic biopsy in up to 20% of cases due to the absence or only minimal residual carcinoma in glossectomy specimens. In 11.5% of apparently pT2 cases, DOI may be underestimated due to the positive deep margin. Rarely, extratumoral PNI or lymphatic invasion may be the deepest point of invasion. Overall, two issues (absent or minimal residual disease and positive deep margin) may confound DOI measurement in early SCCs of oral tongue.

https://ift.tt/2r2mC7i

Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature

Abstract

Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Skin lesions are present for an average of > 6 years before oral involvement occurs. The clinical appearance is highly variable with tongue, palate and gingiva most often affected. We report 3 additional cases of oral MF, including one in which oral lesions are the initial disease presentation. Survival in patients presenting with oral MF is improving and can be attributed to advances in therapy.

https://ift.tt/2vUqzjc

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges

Abstract

The 8th edition of American Joint Committee on Cancer (AJCC 8th) staging manual incorporated depth of invasion (DOI) into pT stage of oral cavity cancer. The aim of this study was to characterize several histological findings that may complicate measurement of DOI in early conventional squamous cell carcinomas (SCC) of the oral tongue: (1) lack of or minimal residual carcinoma following biopsy; (2) positive deep margin; (3) extratumoral perineural invasion (PNI); and (4) lymphatic or vascular invasion. Conventional SCC of the oral tongue (n = 407) with the largest dimension of ≤ 4 cm and with a negative elective cervical lymph node dissection (pN0) were reviewed. A clear plastic ruler was used to measure DOI by dropping a "plumb line" to the deepest point of the invasive tumor from the level of the basement membrane of the normal mucosa closest to the invasive tumor. Examples of identifying  reference point on the mucosal surface of oral tongue from which to measure the DOI are illustrated. In the experience of one contributing institution, the residual carcinoma was absent in 14.2% of glossectomies (34/239), while in 4.8% of cases (10/205) there was only minimal residual carcinoma. In 11.5% (21/183) of pT2 cases the deep margin was positive and thus DOI and pT may be underestimated. Of all cases with PNI, extratumoral PNI was identified in 23.1% (31/134) of cases, but represented the deepest point of invasion in only two cases. In one case, lymphatic invasion represented the deepest point of invasion and could have led to upstaging from pT1 to pT2. In conclusion, DOI measurement for SCC of the oral tongue may require re-examination of the diagnostic biopsy in up to 20% of cases due to the absence or only minimal residual carcinoma in glossectomy specimens. In 11.5% of apparently pT2 cases, DOI may be underestimated due to the positive deep margin. Rarely, extratumoral PNI or lymphatic invasion may be the deepest point of invasion. Overall, two issues (absent or minimal residual disease and positive deep margin) may confound DOI measurement in early SCCs of oral tongue.

https://ift.tt/2r2mC7i

The Spectral Arctic

McCorristine, Shane; (2018) The Spectral Arctic. [Book]. UCL Press: London, UK. Green open access

https://ift.tt/2Hu7dHm

Comparative clinical effectiveness and cost effectiveness of endovascular strategy v open repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial

Gomes, M; (2017) Comparative clinical effectiveness and cost effectiveness of endovascular strategy v open repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial. BMJ , 359 , Article j4859. 10.1136/bmj.j4859 . Green open access

https://ift.tt/2qWKCYK

How household thermal routines shape UK home heating demand patterns

Hanmer, C; Shipworth, M; Shipworth, D; Carter, E; (2018) How household thermal routines shape UK home heating demand patterns. Energy Efficiency 10.1007/s12053-018-9632-x . (In press). Green open access

https://ift.tt/2HrEi6J

R-matrix calculations of electron-molecule collisions: flexible implementation and practice

Brigg, Will; (2018) R-matrix calculations of electron-molecule collisions: flexible implementation and practice. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2r1TRqK

High precision in protein contact prediction using fully convolutional neural networks and minimal sequence features

Kandathil, SM; Jones, DT; (2018) High precision in protein contact prediction using fully convolutional neural networks and minimal sequence features. Bioinformatics (In press).

https://ift.tt/2HuYqFb

Believing in Negotiation: Reflection on Law’s Regulation of Religious Symbols in State Schools

Hunter-Henin, M; (2016) Believing in Negotiation: Reflection on Law's Regulation of Religious Symbols in State Schools. In: Negotiating with religion: cross-disciplinary perspectives. Routledge: London, United Kindom. Green open access

https://ift.tt/2r0ZSE8

Late Maastrichtian carbon isotope stratigraphy and cyclostratigraphy of the Newfoundland Margin (Site U1403, IODP Leg 342)

Batenburg, SJ; Friedrich, O; Moriya, K; Voigt, S; Cournède, C; Moebius, I; Blum, P; ... IODP Expedition Scientists, .; + view all Batenburg, SJ; Friedrich, O; Moriya, K; Voigt, S; Cournède, C; Moebius, I; Blum, P; Bornemann, A; Fiebig, J; Hasegawa, T; Hull, PM; Norris, RD; Röhl, U; Sexton, PF; Westerhold, T; Wilson, PA; IODP Expedition Scientists, .; - view fewer (2018) Late Maastrichtian carbon isotope stratigraphy and cyclostratigraphy of the Newfoundland Margin (Site U1403, IODP Leg 342). Newsletters on Stratigraphy , 51 (2) pp. 245-260. 10.1127/nos/2017/0398 .

https://ift.tt/2HqD3Vc

Heavy element partitioning and the evolution of the magma ocean

Braithwaite, JWH; (2018) Heavy element partitioning and the evolution of the magma ocean. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2r1XcWH

Synthesis of recombinant antibacterial proteins in the Chlamydomonas reinhardtii chloroplast

Blanshard, Maximilian Edward Alfred; (2018) Synthesis of recombinant antibacterial proteins in the Chlamydomonas reinhardtii chloroplast. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2Hu8Rsv

Furthering Precision in Sentinel Node Navigational Surgery for Oral Cancer: a Novel Triple Targeting System

Chand, M; Keller, DS; Devoto, L; McGurk, M; (2018) Furthering Precision in Sentinel Node Navigational Surgery for Oral Cancer: a Novel Triple Targeting System. Journal of Fluorescence 10.1007/s10895-018-2211-x . (In press).

https://ift.tt/2r1WUPB

Fault-tolerant Quantum Computation with Realistic Error Models

Auger, JM; (2018) Fault-tolerant Quantum Computation with Realistic Error Models. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2Hs7aeV

Molecular characterisation of childhood craniopharyngioma and identification and testing of novel drug targets

Apps, John Richard; (2018) Molecular characterisation of childhood craniopharyngioma and identification and testing of novel drug targets. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2r1WR6n

The optical inverse problem in quantitative photoacoustic tomography

An, L; (2018) The optical inverse problem in quantitative photoacoustic tomography. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2HuhtPG

Developing models to study the mechanisms of weakness and myotonia in Periodic Paralysis

Amior, N; (2018) Developing models to study the mechanisms of weakness and myotonia in Periodic Paralysis. Doctoral thesis (Ph.D), UCL (Univeristy College London. Green open access

https://ift.tt/2r1WI2P

Spectrophotometric Redshifts in the Faint Infrared Grism Survey: Finding Overdensities of Faint Galaxies

Pharo, J; Malhotra, S; Rhoads, J; Ryan, R; Tilvi, V; Pirzkal, N; Finkelstein, S; ... Pasquali, A; + view all Pharo, J; Malhotra, S; Rhoads, J; Ryan, R; Tilvi, V; Pirzkal, N; Finkelstein, S; Windhorst, R; Grogin, N; Koekemoer, A; Zheng, Z; Hathi, N; Kim, K; Joshi, B; Yang, H; Christensen, L; Cimatti, A; Gardner, JP; Zakamska, N; Ferreras, I; Hibon, P; Pasquali, A; - view fewer (2018) Spectrophotometric Redshifts in the Faint Infrared Grism Survey: Finding Overdensities of Faint Galaxies. The Astrophysical Journal , 856 (2) 10.3847/1538-4357/aaadfc . Green open access

https://ift.tt/2r2HvhQ

A novel coarse-grained molecular dynamics method for the accurate prediction of helix-helix interactions in GPCRs

Altwaijry, NAS; (2018) A novel coarse-grained molecular dynamics method for the accurate prediction of helix-helix interactions in GPCRs. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2HxxYuA

The Speech-evoked Auditory Brainstem Response in Adults: An Objective Test for the Diagnosis of Auditory Processing Disorders

Ajiboye, Francis; (2018) The Speech-evoked Auditory Brainstem Response in Adults: An Objective Test for the Diagnosis of Auditory Processing Disorders. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2r2W3hF

The application of aperture synthesis techniques to satellite radar altimetry

Purseyyed, B; (1990) The application of aperture synthesis techniques to satellite radar altimetry. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2HvmYxG

Errance médicale des patients atteints d’hidradénite suppurée : un problème majeur et persistant. Étude « R-ENS Verneuil »

Publication date: Available online 26 April 2018
Source:Annales de Dermatologie et de Vénéréologie
Author(s): J. Loget, C. Saint-Martin, P. Guillem, L. Kanagaratnam, P.-A. Becherel, A. Nassif, A.-C. Fougerousse, M. Siham, C. Girard, H. Barthelemy, G. Chaby, G. Gabison, J.-L. Perrot, V. Pallure, N. Beneton, T. Boye, C. Jacobzone, E. Begon, P. Bernard, Z. Reguiai
ObjectifL'objectif principal de cette étude était d'analyser les facteurs associés à l'existence d'un délai diagnostique significatif chez les patients atteints d'hidradénite suppurée (HS) en France.Malades et méthodesCette étude nationale prospective multicentrique réalisée d'octobre 2015 à mars 2016 incluait tous les patients consultant pour une HS. Les données concernant les patients étaient recueillies à l'aide d'un questionnaire standardisé. Des analyses univariée et multivariée ont été effectuées afin de recueillir les facteurs associés à un délai diagnostique significatif, défini comme un délai d'au moins 5,5 ans entre les premiers signes de la maladie et son diagnostic formel.RésultatsLes 16 centres ont inclus 312 patients (62 % de femmes) d'âge moyen 35 ans. L'âge moyen de début de l'HS était de 22 ans. Respectivement 170 (54 %), 114 (37 %) et 45 (15 %) patients avaient consulté au moins 3, 5 et 10 médecins avant le diagnostic formel, qui était posé par un dermatologue dans 64 % des cas. Les premiers signes d'HS étaient apparus en moyenne 6,2 ans avant la première consultation de dermatologie et 8,4 ans avant le diagnostic. Un tabagisme actif (Odd Ratio (OR) ajusté 1,85; p=0,027) et un début des signes à un âge plus précoce (OR ajusté 0,92; p<0,001) étaient associés à un délai diagnostique significatif.ConclusionCes résultats soulignent l'errance médicale des patients atteints d'HS, mais ne montrent pas d'association entre les caractéristiques sociodémographiques ou économiques des patients et l'existence d'un délai diagnostique significatif.ObjectiveTo provide physicians with an understanding of the factors behind significant delays in the diagnosis of hidradenitis suppurativa (HS) in France.Patients and methodsThis prospective multicentre national study conducted from October 2015 to March 2016 included all patients consulting for HS. Patient data were collected by means of a standardized questionnaire. Univariate and multivariate analyses were conducted to collect factors associated with a significant time to diagnosis of at least 5.5years, defined as the period between the onset of initial clinical signs and the time of formal diagnosis.ResultsThe 16 participating centres enrolled 312 patients (62% women), of average age 35years. The average age at onset of HS was 22years. Before formal diagnosis by a dermatologist (64% of cases), 170 (54%), 114 (37%) and 45 (15%) patients had previously consulted at least 3, 5 and 10 general physicians, respectively. The average time between the initial clinical signs of HS, the first dermatology visit and the definitive diagnosis was 6.2 and 8.4 years, respectively. Active smoking (OR adjusted 1.85; P=0.027) and disease onset at a younger age (adjusted OR 0.92; P<0.001) were both associated with significant delays in diagnosis.ConclusionThese results emphasized misdiagnosis among HS patients but did not evidence any association between either sociodemographic or economic characteristics and the existence of significant times to diagnosis.



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Intraoperative pediatric acupuncture is widely accepted by parents

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): James W. Ochi, Andrew C. Richardson
ObjectiveMedical acupuncture is increasingly recognized for reducing postoperative pain, nausea and emergence agitation. Anesthetic induction is an ideal time to perform acupuncture in an effort to reduce the adverse side effects of surgery. Acupuncture is safe, inexpensive and does not lengthen the duration of anesthesia. There are however no published reports of how often patients will choose intraoperative acupuncture when given the opportunity to do so.MethodsA retrospective review of all surgical procedures performed by one surgeon over 12 months was done. This yielded 401 unique patients ranging in age from 3 months to 21 years with a mean of 6 years. Five of these patients had emergent surgery and 396 patients had scheduled surgery; there were a total of 822 surgical procedures performed on these individuals. Intraoperative acupuncture was offered only to the scheduled surgical patients.Results388 of 396 (98%) parents chose to have intraoperative acupuncture done for their child. No complications of acupuncture were encountered.ConclusionThese results demonstrate strong acceptance of intraoperative acupuncture by parents. We hope this report encourages surgeons to become trained in medical acupuncture.



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Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals

Background. Besides the extensive regulatory role in growing number of biologic processes, vitamin D has been recently considered essential for lungs function as well as protective against exacerbation of chronic obstructive pulmonary diseases. We assessed the correlation between vitamin D serum levels with pulmonary function in healthy individuals. Methods. In a cross-sectional study, healthy volunteer participants underwent the following laboratory procedures: a blood test, a 24-hour urine collection test, and the serum level of 25-hydroxy vitamin D before undergoing spirometry. Linear correlation coefficient was calculated to detect the association between serum level of 25-hydroxy vitamin D and pulmonary volumes. Results. The mean age of participants was years. 48% of participants showed different levels of 25-hydroxy vitamin D deficiency. We recognized a consistent direct positive correlation between serum levels of 25-hydroxy vitamin D and lung function volumes. The coefficient for forced vital capacity, forced expiratory volume in 1 second, forced expiratory flow 25–75%, and forced expiratory volume in 1 second/forced vital capacity ratio were 0.610, 0.509, 0.454, and 0.551, respectively. Conclusions. Our findings suggest correlation between higher serum levels of 25-hydroxy vitamin D and improved pulmonary function. Accordingly, supplemental vitamin D might significantly improve treatment response.

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Vibrant Soundbridge Implantation: Floating Mass Transducer Coupled with the Stapes Head and Embedded in Fat

Subtotal petrosectomy may be performed for refractory chronic middle ear diseases, such as massive cholesteatoma or recurrent otitis media. It involves permanent obliteration of the operative cavity, thus precluding the chance to restore conductive hearing via traditional inertial ossicular prostheses. The Vibrant Soundbridge (VSB) is an alternative option for hearing rehabilitation. Vibrant energy is delivered into the inner ear via a floating mass transducer (FMT), which can be coupled with any part of the middle ear acoustic transmission structure. To restore the hearing of a young woman with cholesteatoma, we combined subtotal petrosectomy with obliteration of the cavity and VSB implantation with an FMT coupled to the stapes head. Two years of follow-up demonstrated excellent auditory rehabilitation, improved sound source localization ability, and a lower speech recognition threshold. This study showed that the FMT works well in an obliterated cavity, and the experience acquired through this successful exploration is worth disseminating.
ORL 2018;80:159–164

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Drug Induced Sleep Endoscopy Identification of Adenoid Regrowth in Pediatric Obstructive Sleep Apnea

Objective. To establish the incidence and possible contributing factors leading to adenoid regrowth in children with pediatric sleep apnea using drug induced sleep endoscopy (DISE). Methods. Children treated for obstructive sleep apnea following previous adenoidectomy were evaluated using DISE. Adenoid regrowth was scored by the same attending physician using a 5-point grading scale. Age, sex, body mass index (BMI) percent for age, polysomnogram results, initial adenoid size before adenoidectomy, and postoperative complications were evaluated. Results. Fifty-six patients (age range 22 months to 16 years) met inclusion criteria. Twenty-five children (44.6%) had Grade 2 adenoid or larger. Mean age at the time of DISE was 7.11 years, with an average of 1.75 years since initial adenoidectomy. Mean preadenoidectomy size based on intraoperative nasopharyngeal mirror assessment was Grade 2.55 (95% CI 2.30–2.79). Adenoid size at time of sleep endoscopy was Grade 1.64 (95% CI 1.30–1.98). Characteristics associated with adenoid regrowth were higher body mass index for age percentile at time of endoscopy (), initial adenoid size (), and time between initial adenoidectomy and endoscopy (). Conclusions. Body mass index for age percentile, initial adenoid size, and time between initial adenoidectomy and drug induced sleep endoscopy correlate with regrowth in childhood obstructive sleep apnea.

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Acid‐regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization

Helicobacter, EarlyView.


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Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia

Helicobacter, EarlyView.


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Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

Helicobacter, EarlyView.


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Anaplasic astrocytoma with exophytic growth in Sylvian fissure in a pediatric patient: a case report

Abstract

Gliomas are the most frequent supratentorial intracranial tumors in the pediatric population. Usually, they are intra-axial lesions with a characteristic image pattern, however, there are few reported cases of gliomas with exophytic growth. There are no previous reports in the literature of gliomas with exophytic growth in the Sylvian fissure. Fourteen year-old female patient who started with seizures. In imaging studies, a neoplasic mass with an exophytic portion in the left Sylvian fissure was found. Macroscopically, total resection was performed, definitive diagnosis was anaplastic astrocytoma. She presented recurrence and is currently receiving adjuvant treatment. Supratentorial gliomas with exophytic growth are extremely rare. We report the first case in the pediatric population, and we consider it is important to know its imaging and macroscopic characteristics for its initial management and to take it into account as a differential diagnosis of exophytic lesions.

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Colovaginal and colo-ovarian fistula at a patient with asymptomatic diverticular disease

Abstract

Colovaginal and colo-ovarian fistulas are rare entities that could be attributed to diverticular disease after an episode of acute diverticulitis. Τhey could initially be manifested with symptoms that lead patients to the gynecologist. Gynecologists should consider them in the differential diagnosis, especially after recurrent episodes of sinusitis. We report the case of a 51-year-old woman with a colovaginal and a colo-ovarian fistula due to subclinical diverticular disease, which should be involved in the differential diagnosis in those complicated fistulas, even if the patient had never before a clinical episode of acute diverticulitis or known diverticular disease, and a successful surgical approach.

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A rare presentation of acute appendicitis in right upper quadrant caused by renal agenesis

Abstract

Diagnosing acute abdominal pain will always be a challenging task, patients frequently present with atypical symptoms. It is crucial for a clinician to have good differential diagnosis to avoid delay in diagnosis and treatment. We present 37-year-old male who presented to emergency department with 2 days of abdominal pain. The pain started centrally around his umbilicus and localized to his right upper quadrant (RUQ). Clinical examination showed he has localized peritonitism on the RUQ hence he was further investigated with CT abdomen. CT revealed he has appendicitis. This is due to the congenital anomaly where he has congenital agenesis of his right kidney. This case illustrates in patients with congenital agenesis of right kidney, the diagnosis of acute appendicitis should be considered in right upper quadrant pain. He was commenced on IV antibiotics and proceeded to have laparoscopic appendicectomy. He had an uneventful post-operative recovery.

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A novel combined approach using a Penumbra catheter and balloon catheter for cerebral venous sinus thrombosis

Cerebral venous sinus thrombosis is sometimes fatal. We describe a case of sinus thrombosis in a 43-year-old woman presenting with generalized seizure, delirium, and a 2 week history of headache and nausea. The patient underwent mechanical thrombectomy using a novel combined approach, in which a Shouryu HR balloon catheter (Kaneka) was anchored in the right transverse sinus (TS), sigmoid sinus (SS), and superior sagittal sinus (SSS), while a Penumbra 5 MAX ACE (Penumbra) catheter was moved back and forth between the right TS, SS, and SSS. Additionally, back and forth movement of the inflated balloon with aspiration—the so-called 'dental floss technique'—was performed. Partial recanalization was eventually obtained. Follow-up angiography on postoperative day 7 showed a dramatic improvement in venous outflow. The patient was transferred to a rehabilitation hospital on postoperative day 42. We describe our combined approach using aspiration, and Penumbra and balloon catheters, to achieve mechanical thrombectomy for sinus thrombosis.

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Fungating breast mass in a developed country

Description 

A 56-year-old woman presented to the emergency department with a left breast mass. Initially, she noticed two small lumps on the left breast that evolved in 18 months into an ulcerated mass with foul-odour drainage. Four months prior to admission, she developed fevers, fatigue and progressive dyspnoea. She normally could walk a block without limitations but progressed to dyspnoea with minimal exertion. Her family noted that she was spending most of the day in bed secondary to fatigue. Her fevers measured as high as 101.5°F and was alleviated by acetaminophen. One week prior to admission, she had a syncopal episode while standing up from her couch. Her mother came to visit after the syncope and noticed a foul odour. After she revealed the mass to her mother, she was taken to a primary care doctor who recommended the emergency department. The patient had no known medical history. She...

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Psychosis, creativity and recovery: exploring the relationship in a patient

Relation between mental illness and creativity is intricate. While many creative people show signs of mental illness, persons with severe mental illness occasionally have creative output beyond the ordinary. We are presenting a patient with psychotic illness whose creative potential took a positive turn during the illness phase and grew further following symptomatic improvement and helped in her recovery process. Observing the contrast related to creative productivity pre and post psychotic phase raises the probability of whether psychotic illness or process might enhance creative potential. The case additionally illustrates how creativity can be a useful method supporting recovery from severe mental illnesses.

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Intensive care management of severe hypernatraemia in the context of group A streptococcal septicaemia

This case describes a 54-year-old woman with exudative eczema, who was admitted to the intensive care unit with a serum sodium concentration of 191 mmol/L, secondary to profound dehydration in the context of group A streptococcal septicaemia. Successful rehydration and electrolyte normalisation was achieved with continuous venovenous haemodiafiltration (CVVHDF), the replacement fluid of which was infused with hypertonic saline to limit the rate of sodium reduction. This case report comments on three areas of interest. First, hypernatraemia of this level is unusual. Second, the infusion of hypertonic saline into the replacement fluid of the CVVHDF filter is not common practice but successfully ensured a controlled reduction in serum sodium concentration while aggressively replacing a 9 L water deficit. Third, the notable physiological reserve demonstrated by the patient: despite an extraordinary serum sodium concentration in the context of overwhelming streptococcal septicaemia, she has made a full cognitive recovery.

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Isolated solitary recurrent skull metastasis in papillary thyroid carcinoma

Description  

A 38-year-old woman presented with history of painless expansible swelling in the right frontoparietal region since 2 years and rapidly increasing in size since the last 6 months. She was initially evaluated in another centre and was diagnosed as a meningioma. She had a history of total thyroidectomy and radioiodine ablation for a non-metastatic papillary carcinoma thyroid (PCT) in the year 2008. She was on a regular follow-up between 2009 and 2012 and during that period her serum thyroglobulin and whole-body iodine scan was normal. However, she was lost to follow-up but she had continued her suppressive doses of thyroxin.

Her T1-weighted MRI showed a lobulated expansile, intensely heterogeneously enhancing lesion arising from the right frontoparietal region (size 77x52x88 cm) (figure 1). The fluorodeoxyglucose-positron emission tomography (PET) CT scan showed a metabolically active expansile soft tissue lesion (standard uptake values, 64) with lytic area and bony spicules (

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Cardiac CT confirmation of normal prosthetic mechanical aortic valve function in patient with presyncope and significantly increased Doppler velocities

Description 

A 37-year-old man presented to our emergency department with unprovoked presyncope, breathlessness and atypical chest pain. His history included a Carbomedics 27 mm bileaflet mechanical aortic valve replacement (AVR) 18 years prior for endocarditis, severe aortic regurgitation and left ventricular systolic dysfunction (LVSD). A biventricular pacemaker (cardiac resynchronisation therapy with defibrillator (CRT-D)) was implanted 7 years later. Observations, including postural blood pressure, biventricular-paced ECG and bloods including troponin and D-dimer assays, were unremarkable. CRT-D interrogation demonstrated no arrhythmias. Although the international normalised ratio (INR) was satisfactory on admission (2.8), compliance with taking daily warfarin was inconsistent with poor anticoagulation clinic attendance. The time spent in therapeutic INR range was hence only 60%.

Given the above and increasing Doppler AVR velocities on transthoracic echocardiography (TTE) 2 years prior (VMax 2.6 m/s (mean gradient 26 mm Hg) vs VMax 1.6 m/s (mean gradient 7 mm Hg) 8 years ago), TTE was repeated (figure 1A,B). This...

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Fatal case of commercial moisture absorber ingestion

Description 

One of the most commercially available moisture absorbers is a dehydrating agent containing calcium chloride. In humid environments such as basements, kitchens, cabinets and closets, calcium chloride provides effective moisture absorption by becoming highly concentrated calcium chloride brine. Ingestion of calcium chloride can lead to severe hypercalcaemia and can be fatal. In our case, hypercalcaemia developed from intentional ingestion of moisture absorber and the patient eventually died. To our knowledge, fatality from commercial moisture of absorber ingestion has not been reported. A 31-year-old man presented to the emergency department (ED) 20 min after intentionally ingesting 300 mL of commercial moisture absorber solution. It contained 300 g of calcium chloride (figure 1). The patient had a history of a pervasive developmental disorder. When the patient first presented to ED, he was alert. The patient's initial symptoms were nausea and vomiting. Gastric lavage was done, and activated charcoal was used....

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