Dermoscopy of skin metastases from breast cancer: two case reports

Cutaneous metastatic breast cancer is the most common cutaneous metastatic malignancy in women. The assessment of cutaneous metastatic disease can be perplexing because the clinical presentation appears simila...

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Rare case of Propionibacterium acnes-related splenic abscess

A 64-year-old woman with a medical history of morbid obesity, chronic hepatitis C, essential hypertension, multiple episodes of abdominal cellulitis, diabetes mellitus type 2 on insulin, intravenous and subcutaneous drug abuse presented to the emergency department complaining of left lower chest pain for 6 weeks along with multiple episodes of vomiting. Initial laboratory data revealed leucocytosis of 17 200x10³/μL with left shift. She reported multiple episodes of fever spikes. Abdominal and pelvic CT showed a splenic hypodense lesion. Specimens from interventional radiology aspiration and splenectomy grew Propionibacterium acnes. Following splenectomy, patient's symptoms resolved. To the best of our knowledge, this would represent the fifth reported case of P. acnes splenic abscess.

https://ift.tt/2Q1311F

Alpha-2 antiplasmin-associated aortic valve thrombus presenting as a STEMI in a patient with Graves disease

Description  

A 36-year-old Caucasian woman with a medical history of Graves disease presented to the emergency department with typical chest pain, and she was found to have a ST-elevation myocardial infarction (STEMI) via ECG and elevated troponins. Emergent cardiac catheterisation revealed distal blockages in the left anterior descending artery and second obtuse marginal artery (figure 1A,B). After distal balloon angioplasty, the decision was made to further treat the patient medically and discharge home after clinical stability was achieved. She was readmitted 2 days later for new onset of palpitations with up-trending troponins. Laboratory tests were significant for a low thyroid-stimulating hormone of <0.01 µLU/mL (reference range: 0.27–4.2 µLU/mL), and elevated free T4 of 4.02 µLU/mL (reference range: 0.9–1.7 ng/dL), free T3 of 4.8 pg/mL (reference range: 2.5–4.3 pg/mL) and a thyroid stimulating immunoglobulin of 386 (reference range: <140% baseline). She was immediately started on both methimazole 20 mg and potassium iodine oral solution (SSKI). Further workup...

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Haemorrhagic cholecystitis: a rare entity not to be forgotten

Haemorrhagic cholecystitis is a rare entity of acute cholecystitis that carries a high morbidity and mortality rate if management is delayed. Its clinical course can mirror that of acute cholecystitis. Characteristic findings on ultrasound or CT scan are useful clues to early diagnosis. Urgent cholecystectomy is required prior to progressing to perforation of gallbladder. Most of the literature are case reports with causes associated with anticoagulation. Herein, we described a morbidly obese patient with poorly controlled diabetes presenting with non-specific right upper quadrant pain and was subsequently diagnosed with haemorrhagic cholecystitis. A review of the literature was also performed to summarise the potential clinical presentations, distinctive imaging findings and management options available for this rare condition.

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Pneumomediastinum: a complication of reinserting a dislodged tracheostomy

Description 

A 54-year-old woman with a background of obesity and hypertension presented following a pulseless electrical activity (PEA) cardiac arrest. Cardiopulmonary resuscitation (CPR) was commenced on arrival of the paramedics and she was intubated and ventilated (figure 1). Return of spontaneous circulation was achieved in the emergency department following a total of 45 min of CPR. No clear cause of her arrest was identified. She was transferred to the intensive care unit (ICU) for post-arrest management.

Figure 1

Initial chest radiograph following return of spontaneous circulation, with endotracheal tube present (included as a baseline for comparison).

Seizure activity off of sedation necessitated further investigation. Her CT head was unremarkable, but her lumbar puncture showed features in keeping with meningitis. She was therefore treated with antibiotics and antiepileptics. Her cerebrospinal fluid viral PCR and blood HIV tests were negative.

Although appropriate seizure control was achieved,...

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Naclerios V sign and continuous diaphragm sign after endoscopy

Description 

An otherwise healthy 72-year-old woman presented with dyspnoea and systemic subcutaneous emphysema. She had undergone upper endoscopy, in which duodenal ulcer was found. The community hospital where the endoscopy was conducted transferred her to our tertiary hospital for further diagnosis and management. On arrival, she complained of severe difficulty in breathing; massive subcutaneous emphysema on her chest to the feet was observed on palpation. Chest X-ray image showed Naclerio's V sign (figure 1A, black arrow) and continuous diaphragm sign (figure 1A, white arrows). CT scan confirmed massive subcutaneous and mediastinal emphysema with pneumothorax, pneumopericardium and free air in retroperitoneal space (figure 1B,C). Emergent laparotomy revealed duodenal perforation, 9 mm in diameter at the descending part of duodenum (figure 1D, white arrow), and was surgically repaired. After the surgery, the emphysema gradually disappeared in weeks and had not recurred at 6-month follow-up.

...

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Hypertrophic pyloric stenosis following repair of oesophageal atresia and tracheo-oesophageal fistula in a neonate

Development of hypertrophic pyloric stenosis (HPS) after a few weeks of repair of an oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF) is a rare condition in early infancy. Although vomiting or feeding intolerance in operated cases of OA+TOF are attributed to oesophageal stricture, gastro-oesophageal reflux and oesophageal dysmotility, it may also be caused by HPS. Herein, we report a newborn infant who had OA and TOF operation on day 2 of life and diagnosed to have HPS at 15th day of age. Even though it is a rare anomaly, HPS should be kept on mind in the presence of persistent vomiting following repair of OA.

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Primary renal angiosarcoma: a diagnostic and therapeutic challenge

Primary renal angiosarcoma is an exceedingly rare and aggressive neoplasm. Although it may occur in youth, this tumour is frequently reported in the sixth and seventh decades of life. The clinical presentation is frequently varied. Pathogenesis remains largely unknown and it has overlapping features with other tumours of the kidney. Current treatment options include variable combinations of surgery, chemotherapy and radiotherapy. Reports regarding the disease prognosis and natural history are limited. In this article, we chronicle the case of a patient with primary renal angiosarcoma presenting at an advanced stage as a widely metastasised tumour. Additionally, we undertake here a brief literature review highlighting the rarity and aggressiveness of this condition, its poor prognosis, and the lack of specific management guidelines.

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Intestinal obstruction with a twist: a rare case of congenital portal vein aneurysm causing intestinal obstruction

Bilious vomiting is often a presenting feature of upper intestinal obstruction in newborn. We present a case of intestinal obstruction in a newborn baby caused by abnormal vascular band arising from portal vein aneurysm in association with a midgut volvulus. Congenital anomalies of portovenous system are very rare, and it usually presents with portal hypertension in late infancy or childhood. In this particular child, the portal vein aneurysm contributed to intestinal obstruction due to both a failure of intestinal rotation and a mechanical band over the transverse colon.

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Significant cephalad lead migration with use of externally powered spinal cord stimulator

Spinal cord stimulation has been an effective therapy for treatment of chronic low back pain over the last four decades. Over the years, there have been significant technological advances in the neuromodulation devices. Externally powered neuromodulation devices, that do not require an internal pulse generator (IPG) implantation, have recently been approved for treatment of chronic pain and the data on potential pitfalls and unforeseen complications with these devices is minimal. Here, we report a case of a 60-year-old woman with chronic back pain who underwent the implantation of one of such devices and developed complication that required neurosurgical intervention. The epidural stimulator leads in the patient migrated cranially to the T2 level that required extensive neurosurgical exploration. We believe this is the first reported case of such significant cranial epidural lead migration with the use of neurostimulation devices and demands more research into the safety of externally powered neurostimulation devices.

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Intrahepatic sarcomatoid cholangiocarcinoma

Sarcomatoid carcinoma is a rare tumour composed of intermingled malignant epithelial and mesenchymal cells, and it has been reported in various organs including the liver. Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver primary tumour. Here, we report a case of an elderly man who was admitted to our hospital after head trauma. He performed a head CT that diagnosed cerebral metastasis. On abdominal CT, he presented a 10x8x9 cm-sized hypodense liver mass in the VII and VIII segments, with peripheral enhancement. Histological and immunohistochemical examination of the tumour showed a malignant neoplasm with both carcinomatous and sarcomatous components and positive expression of cytokeratin and vimentin antibodies. The patient was diagnosed with intrahepatic sarcomatoid CCC at an advanced stage and died 45 days after the diagnosis. We emphasise the importance of immunohistochemistry which may provide a clue to proper diagnosis.

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Case of colonic mucosal Schwann cell hamartoma and review of literature on unusual colonic polyps

Mucosal Schwann cell hamartomas (MSCH) are benign mesenchymal tumours rarely seen in the gastrointestinal tract. They occasionally present as incidental sessile polyps during colonoscopy. A 55-year-old asymptomatic female patient with a medical history of multiple sclerosis presented for a screening colonoscopy. A 5 mm low-risk tubular adenoma was noted in the caecum, and a second 5 mm polyp was found in the ascending colon. Histopathology of the ascending colon polyp showed proliferation of spindle cells without ganglion cells in the lamina propria. Immunohistochemical findings are compatible with an MSCH. Surveillance colonoscopy was scheduled in 5 years based on the presence of a single low-risk tubular adenoma.

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In this issue

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Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers

Hypopharyngeal cancer is a head and neck cancer with a poor prognosis, and most cases show metastases on diagnosis. Cervical lymph node (LN) metastasis is a poor prognostic factor in hypopharyngeal cancer patients. The identification of risk factors for LN metastasis can help guide surgical treatment strategies for these patients.

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Penicillin minor determinants: History and relevance for current diagnosis

To review the history of the penicillin minor determinants and evaluate their relevance for current diagnosis.

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Cytokine levels in persistent skin lesions of adult-onset Still disease

To the Editor: Adult-onset Still disease (AOSD) is an inflammatory disease characterized by fever, polyarthritis, and skin inflammation, with increased serum levels of interferon-γ (IFN-γ), interleukin 1β (IL-1β), IL-18, IL-6, tumor necrosis factor-α, IL-8, IL-2 receptor, C-X-C motif chemokine 10, and C-X-C motif chemokine 13 (CXCL13).1 The cutaneous manifestations of AOSD include the classic evanescent skin eruption (ESE) and atypical persistent skin eruptions (APSEs), the latter possibly being related to more severe AOSD forms.

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Anesthesia Safety in Otolaryngology

This article highlights the important relationship between the otolaryngologist and anesthesiologist, focusing on intraoperative patient safety for otolaryngologic surgery. In addition, consideration of preoperative history, physical examination, and potential postoperative complications helps guide the otolaryngologist and anesthesiologist in formulating an appropriate and collaborative management strategy.

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Simulation Saves the Day (and Patient)

Surgeons can use simulation to improve the safety of the systems they work within, around, because of, and despite. Health care is a complex adaptive system that can never be completely knowable; simulation can expose aspects of patient care delivery that are not necessarily evident prospectively, during planning, or retrospectively, during investigations or audits. The constraints of patient care processes and adaptive capacity of health care providers may become most evident during simulations conducted "in situ" using real teams and real equipment, in actual patient care locations.

https://ift.tt/2QN8LNr

Patient Safety and Quality for Office-Based Procedures in Otolaryngology

Office-based procedures have increased in frequency with the recent changes in the current health care climate prioritizing improved efficiency and greater value in the care that is delivered. This article focuses on patient safety and quality issues that are specific to procedures in the office setting of an Otolaryngologist. Specific topics are categorized into preprocedure planning, procedural execution, and postprocedure follow-up. Several best practice recommendations are included to promote and simplify the integration of these quality and safety measures into every office setting.

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The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review

Abstract

Head and neck carcinomas (HNCs) collectively are the sixth most common cancer with an annual incidence of about 400,000 cases in the US. The most well-established risk factors for HNCs are tobacco and alcohol abuse. With the increasing public awareness, the incidence of HNCs is decreasing. But there is an increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been observed during the last decade. This phenomena is associated with persistent infection with high-risk HPV. HPV associated OPSCC patients tend to be younger males of high socioeconomic status. The increasing incidence causes a significant loss to social resources, given that it's reported that HPV associated OPSCC represents about 60% of OPSCC cases. There is a growing amount of data supporting the hypothesis that HPV-associated OPSCC has a better survival rate due to a higher sensitivity to chemotherapy and radiotherapy as compared to HPV-unrelated OPSCC. Although the HPV positivity is associated with increased radio-sensitivity, the underlying mechanisms are not yet fully understood. This review summarizes the current knowledge on the effects of HPV infection and its carcinogenesis on the radiosensitivity of OPSCC, from the molecular to histologic level, providing a comprehensive insight of this special tumor entity.

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A new rocuronium formulation not causing vascular pain in a flexor reflex model of anesthetized rats

Abstract

Purpose

Intravenous administration of the brand formulation of rocuronium bromide, currently used as a muscle relaxant, has been associated with vascular pain accompanied by withdrawal movements of the arm and wrist. The purpose of this study was to identify the cause of vascular pain induced by the brand formulation and to develop a new rocuronium formulation, not causing vascular pain, using a vascular pain-evoked flexor reflex response model of anesthetized rats.

Methods

A rat flexor reflex model, monitored by electromyography, was used to evaluate a flexor reflex response as the index of vascular pain. A catheter for drug administration was inserted into the superficial caudal epigastric artery. A needle electrode was inserted into a muscle in the femoral area to obtain an electromyogram (EMG) value. The integrated EMG values obtained after the administration of each test drug were compared to the baseline value and quantified.

Results

The acetate buffer contained in the solvent could cause flexor reflex response. Furthermore, the flexor reflex response increased in an acid concentration-dependent manner. Based on these results, we prepared a new rocuronium formulation using a low-acid-concentration buffer solution and found that it decreased the integrated EMG value in the rat model. The integrated EMG value acquired using the brand formulation was reduced by pretreatment with the TRPA1 channel inhibitor.

Conclusion

Our findings suggest that the high acid concentration in the brand formulation buffer solution is the cause of vascular pain. The rocuronium formulation developed using a low-acid-concentration buffer solution might help eliminate vascular pain in the clinic.

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Normocomplementaemic urticarial vasculitis: effective treatment with omalizumab

We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting ...

https://ift.tt/2MSxTiw

Co-occurrence of mycotoxins in maize food and maize-based feed from small-scale farms in Brazil: a pilot study

Abstract

A limited survey was conducted to assess the co-occurrence of aflatoxins (AF) B₁, B₂, G₁, and G₂; fumonisins (FB) B₁ and B₂; ochratoxin A (OTA); zearalenone (ZEN); and deoxynivalenol (DON) in maize food (N = 26) and animal feed (N = 45) collected from 21 small-scale farms from the states of São Paulo (SP) and Santa Catarina (SC), Brazil. Samples evaluated were maize meal and maize flour for human consumption available in the farm households, and maize-based feed intended for broiler chicks, laying hens, and dairy cows. Analyses of mycotoxins were performed by ultra-performance liquid chromatography coupled with tandem mass spectrometry. The median levels of mycotoxins found in maize food were 2.5 μg/kg (total AF), 120 μg/kg (total FB), 13 μg/kg (ZEN), and 57 μg/kg (DON). All values were below the Brazilian tolerance limits, except for total FB in one sample of maize flour. In feed samples, median levels of total AF, total FB, ZEN, and DON were 100 μg/kg, 680 μg/kg, 160 μg/kg, and 200 μg/kg, respectively. The co-occurrence of two or more mycotoxins was confirmed in 35% and 51% of maize food and feed, respectively. Results indicate a low human exposure to mycotoxins in the small-scale farms evaluated and a higher exposure of farm animals to mycotoxins in the feed.

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Traumatic arteriovenous fistula formation secondary to crush injury

Abstract

We describe a patient who suffered a crush injury after a motor vehicle accident leading to complex pelvic injuries complicated by an AV fistula. Traumatic arteriovenous (AV) fistulas from blunt, non-penetrating injuries are uncommon and rarely described in medical literature. A CT followed by pelvic angiogram performed by interventional radiology revealed a traumatic fistula which was then treated by embolization. Patient underwent exploratory laparotomy, craniotomy and open reduction internal fixation of pelvis and was stabilized prior to discharge to rehabilitation.

https://ift.tt/2xEMXuS

Acute anterograde intussusception as a late complication of distal gastric bypass

Abstract

Small bowel intussusception is an uncommon cause of adult intestinal obstruction after gastric bypass for morbid obesity. It usually affects the Roux or the common limb at the jejunojejunostomy site and is mainly retrograde. An altered motility of the Roux limb seems to be the main explanation for its developement. We report the case of a patient with a late acute anterograde intussusception after a previous distal Roux-en-Y gastric bypass. Clinical, radiological and operative findings are presented and surgical solutions described in the literature are reviewed.

https://ift.tt/2QPfI0r

Large rib osteochondroma in a child in Aleppo, Syria

Abstract

Background

Osteochondromas are the most common tumors of the long bones in children. Osteochondromas can rarely be seen in the chest wall and they are usually diagnosed at a young age. They can be sporadic or part of the hereditary multiple exostoses.

Case presentation

We report a 12-year-old boy, who presented with a hard and large mass in the chest wall. The mass grew slowly after the original resection. Diagnosis and treatment were delayed because of the war. Radiological examination showed a large calcified tumor pushing the upper lung lobe. He was treated surgically. Pathology confirmed the diagnosis of an osteochondroma with no evidence of malignancy.

Conclusion

Osteochondroma occur most frequently in long bones next to the metaphysic. These tumors can also develop in unusual sites. Wide total excision with negative margins is important to prevent recurrence.

https://ift.tt/2xHTSmK

Wilkie’s syndrome, a missed opportunity

Abstract

Wilkie's syndrome is a rare cause of duodenal obstruction that can easily be missed at clinical practice. It is characterized by nausea, abdominal pain and vomit. It usually affects young adults, and it's caused by a low aortomesenteric angle resulting in vascular compression of the duodenum. Symptoms could resemble many of the symptoms presented in a patient with a suspected eating disorder. The non-specificity of the clinical signs and symptoms can confuse, delay the diagnosis and expose the patient to potentially hazardous therapies. We report a case of a 20-year-old patient who presented to the emergency room with a history of intermittent vomiting and abdominal pain. He had been previously misdiagnosed with an eating disorder and received physiological therapy. Nonetheless, his pain persisted. After further evaluation with the use of imaging techniques, a low aortomesenteric angle was discovered. He underwent surgery and completely recovered. On follow up controls patient is well and he no longer had episodes of vomiting.

https://ift.tt/2QPg8nt

Quasar - CIV forest cross-correlation with SDSS DR12

Gontcho, SGA; Miralda-Escude, J; Font-Ribera, A; Blomqvist, M; Busca, NG; Rich, J; (2018) Quasar - CIV forest cross-correlation with SDSS DR12. Monthly Notices of the Royal Astronomical Society (MNRAS) , 480 (1) pp. 610-622. 10.1093/mnras/sty1817 . Green open access

https://ift.tt/2QOQkYQ

'What gets measured gets managed': revisiting the indicators for maternal and newborn health programmes

Moran, AC; Moller, AB; Chou, D; Morgan, A; El Arifeen, S; Hanson, C; Say, L; ... Costello, A; + view all Moran, AC; Moller, AB; Chou, D; Morgan, A; El Arifeen, S; Hanson, C; Say, L; Diaz, T; Askew, I; Costello, A; - view fewer (2018) 'What gets measured gets managed': revisiting the indicators for maternal and newborn health programmes. Reproductive Health , 15 , Article 19. 10.1186/s12978-018-0465-z . Green open access

https://ift.tt/2xEhGrM

A novel rare event approach to measure the randomness and concentration of road accidents

Curiel, RP; Ramirez, HG; Bishop, SR; (2018) A novel rare event approach to measure the randomness and concentration of road accidents. PLoS ONE , 13 (8) 10.1371/journal.pone.0201890 . Green open access

https://ift.tt/2QOd76Y

Search for supersymmetry in final states with charm jets and missing transverse momentum in 13 TeV pp collisions with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... Araujo Pereira, R; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; Arai, Y; Araque, JP; Araujo Ferraz, V; Araujo Pereira, R; - view fewer (2018) Search for supersymmetry in final states with charm jets and missing transverse momentum in 13 TeV pp collisions with the ATLAS detector. Journal of High Energy Physics , 2018 (9) 10.1007/JHEP09(2018)050 . Green open access

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Designing a graduate entry route for police recruits: lessons from a rapid evidence assessment of other professions

Belur, JS; Tompson, L; Agnew Pauley, W; (2019) Designing a graduate entry route for police recruits: lessons from a rapid evidence assessment of other professions. Police Practice and Research (In press).

https://ift.tt/2QQ07O9

Toward Dual-functional Radar-Communication Systems: Optimal Waveform Design

Liu, F; Zhou, L; Masouros, C; Li, A; Luo, W; Petropulu, AP; (2018) Toward Dual-functional Radar-Communication Systems: Optimal Waveform Design. IEEE Transactions on Signal Processing , 66 (16) pp. 4264-4279. 10.1109/TSP.2018.2847648 . Green open access

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Overview of the Dark Energy Spectroscopic Instrument

Martini, P; Bailey, S; Besuner, RW; Brooks, D; Doel, P; Edelstein, J; Eisenstein, D; ... Wechsler, R; + view all Martini, P; Bailey, S; Besuner, RW; Brooks, D; Doel, P; Edelstein, J; Eisenstein, D; Flaugher, B; Gutierrez, G; Harris, SE; Honscheid, K; Jelinsky, P; Joyce, R; Kent, S; Levi, M; Prada, F; Poppett, C; Rabinowitz, D; Rockosi, C; Cardiel Sas, L; Schlegel, DJ; Schubnell, M; Sharples, R; Silber, JH; Sprayberry, D; Wechsler, R; - view fewer (2018) Overview of the Dark Energy Spectroscopic Instrument. In: Proceedings Volume 10702, Ground-based and Airborne Instrumentation for Astronomy VII; 107021F (2018). SPIE: Austin, Texas, United States. Green open access

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The characteristics of pallidal low-frequency and beta bursts could help implementing adaptive brain stimulation in the parkinsonian and dystonic internal globus pallidus

Pina_Fuentes, D; van Zijl, J; van Dijk, M; Little, SJ; Tinkhauser, G; Oterdoom, M; Tijssen, M; Pina_Fuentes, D; van Zijl, J; van Dijk, M; Little, SJ; Tinkhauser, G; Oterdoom, M; Tijssen, M; Beudel, M; - view fewer (2018) The characteristics of pallidal low-frequency and beta bursts could help implementing adaptive brain stimulation in the parkinsonian and dystonic internal globus pallidus. Neurobiology of Disease (In press).

https://ift.tt/2xAcncM

Attractor-like dynamics in belief updating in schizophrenia

Adams, RA; Napier, G; Roiser, JP; Mathys, C; Gilleen, J; (2018) Attractor-like dynamics in belief updating in schizophrenia. Journal of Neuroscience 10.1523/JNEUROSCI.3163-17.2018 . (In press).

https://ift.tt/2QQ070B

The 1831 eruption of Babuyan Claro that never happened: has the source of the one of the largest volcanic climate forcing events of the nineteenth century been misattributed?

Garrison, CS; Kilburn, CRJ; Edwards, SJ; (2018) The 1831 eruption of Babuyan Claro that never happened: has the source of the one of the largest volcanic climate forcing events of the nineteenth century been misattributed? Journal of Applied Volcanology , 7 , Article 8. 10.1186/s13617-018-0078-9 . Green open access

https://ift.tt/2xEJY5r

Collecting Multiple Data Linkage Consents in a Mixed-mode Survey: Evidence from a large-scale longitudinal study in the UK

Calderwood, L; Thornby, M; Gaia, A; Kotecha, M; Beninger, K; (2018) Collecting Multiple Data Linkage Consents in a Mixed-mode Survey: Evidence from a large-scale longitudinal study in the UK. Survey Methods: Insights from the Field 10.13094/SMIF-2018-00004 . Green open access

https://ift.tt/2QUtIpY

Children’s levels of contingent self-esteem and social and emotional outcomes

Moore, JSB; Smith, M; (2018) Children's levels of contingent self-esteem and social and emotional outcomes. Educational Psychology in Practice , 34 (2) pp. 113-130. 10.1080/02667363.2017.1411786 .

https://ift.tt/2xDE3O5

African Urbanisation and Urbanism: Implications for risk accumulation and reduction

Dodman, D; Leck, H; Rusca, M; Colenbrander, S; (2017) African Urbanisation and Urbanism: Implications for risk accumulation and reduction. International Journal of Disaster Risk Reduction , 26 pp. 7-15. 10.1016/j.ijdrr.2017.06.029 . Green open access

https://ift.tt/2QPB51W

An Interaction Potential to Study the Thermal Structure Evolution of a Thermoelectric Material: Β‐cu2se

Namsani, S; Gahtori, B; Auluck, S; Singh, JK; (2017) An Interaction Potential to Study the Thermal Structure Evolution of a Thermoelectric Material: Β‐cu2se. Journal of Computational Chemistry , 38 (25) pp. 2161-2170. 10.1002/jcc.24865 . Green open access

https://ift.tt/2xDDSlT

Fecasting volcanic eruptions: beyond the Failure Forecast Method

Kilburn, CRJ; (2018) Fecasting volcanic eruptions: beyond the Failure Forecast Method. Frontiers in Earth Science , 6 , Article 133. 10.3389/feart.2018.00133 . Green open access

https://ift.tt/2QLBanj

Compassion focused therapy for people with dementia: A feasibility study

Craig, C; Hiskey, S; Royan, L; Poz, R; Spector, A; (2018) Compassion focused therapy for people with dementia: A feasibility study. International Journal of Geriatric Psychiatry 10.1002/gps.4977 . (In press).

https://ift.tt/2xEJYlX

Dark matter concentrations in galactic nuclei according to polytropic models

Saxton, CJ; Younsi, Z; Wu, K; (2016) Dark matter concentrations in galactic nuclei according to polytropic models. Monthly Notices of the Royal Astronomical Society , 461 (4) pp. 4295-4316. 10.1093/mnras/stw1626 . Green open access

https://ift.tt/2QLAY7z

Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial

Katzenschlager, R; Poewe, W; Rascol, O; Trenkwalder, C; Deuschl, G; Chaudhuri, KR; Henriksen, T; ... Lees, A; + view all Katzenschlager, R; Poewe, W; Rascol, O; Trenkwalder, C; Deuschl, G; Chaudhuri, KR; Henriksen, T; van Laar, T; Spivey, K; Vel, S; Staines, H; Lees, A; - view fewer (2018) Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. The Lancet Neurology , 17 (9) pp. 749-759. 10.1016/S1474-4422(18)30239-4 .

https://ift.tt/2xCsyXf

Survey of Thermal Plasma Composition in Saturn's Magnetosphere Using Time-of-Flight Data From Cassini/CAPS

Felici, M; Arridge, CS; Wilson, RJ; Coates, AJ; Thomsen, M; Reisenfeld, D; (2018) Survey of Thermal Plasma Composition in Saturn's Magnetosphere Using Time-of-Flight Data From Cassini/CAPS. Journal of Geophysical Research: Space Physics 10.1029/2017JA025085 . (In press).

https://ift.tt/2QPckTh

Modelling the environment around five ultracool dwarfs via the radio domain

Metodieva, YT; Kuznetsov, AA; Antonova, AE; Doyle, JG; Ramsay, G; Wu, K; (2017) Modelling the environment around five ultracool dwarfs via the radio domain. Monthly Notices of the Royal Astronomical Society , 465 (2) pp. 1995-2009. 10.1093/mnras/stw2597 . Green open access

https://ift.tt/2xHaBXl

The Burden of Sinusitis in Hematologic Transplant Patients: A National Perspective

The Laryngoscope, EarlyView.


https://ift.tt/2PTJqAg

Effect of Reversed Tracking Method for Identification of EBSLN in Thyroid Surgery

Conditions:   Thyroid Cancer;   Recurrent Laryngeal Nerve Injuries
Intervention:   Procedure: Reversed Tracking Method
Sponsor:   Fujian Medical University
Not yet recruiting

https://ift.tt/2xGNn3B

Correction to: Complement in the pathogenesis of Alzheimer’s disease

The presentation of Fig. 2 was incorrect.

https://ift.tt/2ptz2nE

Anti-cancer immunotherapy: breakthroughs and future strategies

https://ift.tt/2MS1RmM

Prevalence of potential contact allergens in baby cosmetic products

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2OIjZBF

Real-world-Datenquellen für die Versorgungsforschung zum Hautkrebs

Zusammenfassung

Dermatologische Versorgungsforschung mit dem Ziel der Verbesserung von Prävention, effizienter Diagnostik und Therapie des Hautkrebses braucht Real-world-Daten aus allen Sektoren der Versorgung. Der Beitrag liefert eine Übersicht aktuell verfügbarer, relevanter Real-world-Datenquellen und ihres Nutzungspotenzials und führt beispielhaft Ergebnisse vorliegender Studien auf: Sekundärdatenanalysen mit Abrechnungsdaten der gesetzlichen Krankenkassen wurden genutzt, um u. a. die Teilnahmerate am gesetzlichen Hautkrebsscreening abzuschätzen. Diese betrug im Zweijahreszeitraum ca. 31 %, war in den westlichen Bundesländern höher als in den östlichen und bei Frauen höher als bei Männern. Für die dermatologische Versorgungsplanung stehen regionale Daten in Kombination mit sozialstrukturellen und soziodemografischen Indikatoren zur Verfügung, und die Analyse verweist auf einen Zusammenhang mit der Hautkrebsprävalenz. Primäre Daten sind verfügbar und notwendig zur Erfassung patientenberichteter Endpunkte sowie der arztseitigen Bewertung der Versorgung von Hautkrebspatienten. Umfangreiche histopathologische Datenbanken erfassen neben klinischen auch soziodemografische Parameter und deuten auf einen Zusammenhang von Diagnose- bzw. Therapiezeitpunkt mit dem Versicherungsstatus und Wohnortmerkmalen hin. Neben dem Nutzungspotenzial werden spezifische Limitationen der Datenquellen aufgeführt.

https://ift.tt/2PUgc46

A Critical Need: Increasing Interest in the Field of Allergy and Immunology in Medical Students and Residents

Publication date: Available online 20 September 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Rebecca Scherzer

https://ift.tt/2MS0NQb

Omalizumab as single-dose therapy for vernal keratoconjunctivitis

Publication date: Available online 20 September 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Rachel Simpson, Jason K. Lee

https://ift.tt/2ptr7a2

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

https://ift.tt/2xri65M

Prevalence of self-reported drug hypersensitivity reactions among Lithuanian children and adults

Publication date: Available online 20 September 2018

Source: Allergologia et Immunopathologia

Author(s): V. Kvedariene, B. Sitkauskiene, L. Tamasauskiene, O. Rudzeviciene, V. Kasiulevicius, G. Nekrosyte, E.R. Gomes, P. Demoly

Abstract

Introduction and objectives

Drug hypersensitivity reactions (DHRs) are the adverse effects of drugs that, when taken at doses generally tolerated by normal subjects, clinically resemble allergy. We aimed to assess the prevalence of self-reported DHRs among Lithuanian children and adults and to identify possible risk factors.

Materials and methods

A cross-sectional survey of a population visiting their general practitioners in Vilnius and Kaunas regions of Lithuania was performed. Thirty-five questions on drug allergy symptoms, in addition, food, pollen allergy and family history were included.

Results

3222 (60.0%) children and 2148 (40.0%) adults were included in the study. 7.9% of children and 13.8% of adults reported a DHR for at least one drug (p < 0.001). 69.8% of children and 47.3% of adults, who indicated DHRs, had skin symptoms. Rate of anaphylaxis was similar in both groups (about 10%). 4.5% of children and 7.3% of adults had DHRs induced by antibiotics and this was the most implicated group of drugs. Significant self-reported risk factors for DHRs were family history of DHRs (OR = 6.007, 95%CI 4.756–7.587), pollen allergy (OR = 2.0, 95%CI 1.573–2.544), food allergy (OR = 1.92, 95%CI 1.505–2.448), female gender (OR = 1.439, 95%CI 1.187–1.744) and age (OR = 1.017 in favour of adults, 95%CI 1.013–1.021).

Conclusions

The prevalence of self-reported DHRs in Lithuania is higher among adults than children. Drug-induced skin reactions were the predominant symptom in both groups. Besides female gender and age, a positive family history of DHR and presence of pollen or food allergy may be associated with DHR.

https://ift.tt/2pr7fnK

Molecular diagnostics improves diagnosis and treatment of respiratory allergy and food allergy with economic optimization and cost saving

Publication date: Available online 20 September 2018

Source: Allergologia et Immunopathologia

Author(s): S. Peveri, S. Pattini, M.T. Costantino, C. Incorvaia, M. Montagni, C. Roncallo, D. Villalta, E. Savi

Abstract

Background

Component resolved diagnosis (CRD) allows to precisely identify the sensitization to specific molecules of a given allergenic source, resulting in an important improvement in clinical management, particularly of polysensitized subjects. This will end in the correct prescription of allergen immunotherapy (AIT) for respiratory allergy and in adequate avoidance diets or prescription of self-injectable adrenaline in food allergy.

Objective

The aim of this multicenter, real life study is to evaluate the percentage change of the diagnostic-therapeutic choice in polysensitized patients with respiratory allergy and in patients with food allergy, after using CRD compared to a first level diagnosis, along with an economic analysis of the patient's overall management according to the two different approaches.

Methods

An overall number of 462 polysensitized patients, as suggested by skin prick tests (SPT), and with clinical symptoms related to a respiratory (275 pts) or food (187 pts) allergy, were recruited. All patients underwent CRD for specific IgE against food or inhalant recombinant molecules, which were chosen according to medical history and positivity to SPT. The first diagnostic-therapeutic hypothesis, based only on medical history and SPT, was recorded for each patient while the final diagnostic-therapeutic choice was based on the results from CRD. The rate of change of the diagnostic-therapeutic choice from the first hypothesis to the final choice was statistically evaluated. The economic impact of CRD on the overall management of the allergic patients was analyzed to evaluate whether the increase in the diagnostic costs would be compensated and eventually exceeded by savings coming from the improved diagnostic-therapeutic appropriateness.

Results

An approximate 50% change (k index 0.54) in the prescription of AIT for respiratory allergy as well as a change in the prescription of self-injectable adrenaline (k index 0.56) was measured; an overall saving of financial resources along with a higher diagnostic-therapeutic appropriateness was also detected.

Conclusion

There is moderate agreement concerning prescription of AIT and self-injectable adrenaline before and after performing CRD: this highlights the usefulness of CRD, at least in polysensitized patients, in indicating the risk assessment and therefore the correct therapy of respiratory and food allergy, which results in a cost-saving approach.

https://ift.tt/2MTTN5c

Lentivector Producer Cell Lines with Stably Expressed Vesiculovirus Envelopes

Tijani, M; Munis, AM; Perry, C; Sanber, K; Ferraresso, M; Mukhopadhyay, T; Themis, M; ... Takeuchi, Y; + view all Tijani, M; Munis, AM; Perry, C; Sanber, K; Ferraresso, M; Mukhopadhyay, T; Themis, M; Nisoli, I; Mattiuzzo, G; Collins, MK; Takeuchi, Y; - view fewer (2018) Lentivector Producer Cell Lines with Stably Expressed Vesiculovirus Envelopes. Molecular Therapy - Methods & Clinical Development , 10 pp. 303-312. 10.1016/j.omtm.2018.07.013 . Green open access

https://ift.tt/2DhxneH

Imaging the Zigzag Wigner Crystal in Confinement-Tunable Quantum Wires

Ho, S-C; Chang, H-J; Chang, C-H; Lo, S-T; Creeth, G; Kumar, S; Farrer, I; ... Chen, T-M; + view all Ho, S-C; Chang, H-J; Chang, C-H; Lo, S-T; Creeth, G; Kumar, S; Farrer, I; Ritchie, D; Griffiths, J; Jones, G; Pepper, M; Chen, T-M; - view fewer (2018) Imaging the Zigzag Wigner Crystal in Confinement-Tunable Quantum Wires. Physical Review Letters , 121 (10) 10.1103/PhysRevLett.121.106801 . Green open access

https://ift.tt/2NqgtPw

Effects of plant diversity on simulated climate-vegetation interaction towards the end of the African Humid Period

Groner, Vivienne; (2017) Effects of plant diversity on simulated climate-vegetation interaction towards the end of the African Humid Period. Doctoral thesis (Ph.D), University of Hamburg.

https://ift.tt/2DhwItJ

Dynamic tunable notch filters for the Antarctic Impulsive Transient Antenna (ANITA)

Allison, P; Banerjee, O; Beatty, JJ; Connolly, A; Deaconu, C; Gordon, J; Gorham, PW; ... Young, R; + view all Allison, P; Banerjee, O; Beatty, JJ; Connolly, A; Deaconu, C; Gordon, J; Gorham, PW; Kovacevich, M; Miki, C; Oberla, E; Roberts, J; Rotter, B; Stafford, S; Tatem, K; Batten, L; Belov, K; Besson, DZ; Binns, WR; Bugaev, V; Cao, P; Chen, C; Chen, P; Chen, Y; Clem, JM; Cremonesi, L; Dailey, B; Dowkontt, PF; Hsu, S; Huang, J; Hupe, R; Israel, MH; Kowalski, J; Lam, J; Learned, JG; Liewer, KM; Liu, TC; Ludwig, AB; Matsuno, S; Mulrey, K; Nam, J; Nichol, RJ; Novikov, A; Prohira, S; Rauch, BF; Ripa, J; Romero-Wolf, A; Russell, J; Saltzberg, D; Seckel, D; Shiao, J; Stockham, J; Stockham, M; Strutt, B; Varner, GS; Vieregg, AG; Wang, S; Wissel, SA; Wu, F; Young, R; - view fewer (2018) Dynamic tunable notch filters for the Antarctic Impulsive Transient Antenna (ANITA). Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment , 894 pp. 47-56. 10.1016/j.nima.2018.03.059 .

https://ift.tt/2NvU4Ao

A small population, randomised, placebo-controlled trial to determine the efficacy of anakinra in the treatment of pustular psoriasis: study protocol for the APRICOT trial

Cornelius, V; Wilson, R; Cro, S; Barker, J; Burden, D; Griffiths, CEM; Lachmann, H; ... Smith, C; + view all Cornelius, V; Wilson, R; Cro, S; Barker, J; Burden, D; Griffiths, CEM; Lachmann, H; McAteer, H; Reynolds, N; Pink, A; Warren, RB; Capon, F; Smith, C; - view fewer (2018) A small population, randomised, placebo-controlled trial to determine the efficacy of anakinra in the treatment of pustular psoriasis: study protocol for the APRICOT trial. Trials , 19 (465) 10.1186/s13063-018-2841-y . Green open access

https://ift.tt/2DkA3rO

Educational Systems and Inequalities: International Comparisons

Anders, J; (2018) Educational Systems and Inequalities: International Comparisons. [Review]. Journal of Social Policy , 47 (4) pp. 861-863. 10.1017/S0047279418000466 . (In press). Green open access

https://ift.tt/2Nsk4wx

Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History

Hoffmann, F; Viding, E; Puetz, VB; Gerin, MI; Sethi, A; Rankin, G; McCrory, EJ; (2018) Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History. Journal of the American Academy of Child & Adolescent Psychiatry , 57 (9) 687-695.e4. 10.1016/j.jaac.2018.05.020 . Green open access

https://ift.tt/2DkztKE

VERDICT-AMICO: Ultrafast fitting algorithm for non-invasive prostate microstructure characterisation

Bonet-Carne, E; Johnston, E; Daducci, A; Jacobs, JG; Freeman, A; Atkinson, D; Hawkes, DJ; ... Panagiotaki, E; + view all Bonet-Carne, E; Johnston, E; Daducci, A; Jacobs, JG; Freeman, A; Atkinson, D; Hawkes, DJ; Punwani, S; Alexander, D; Panagiotaki, E; - view fewer (2018) VERDICT-AMICO: Ultrafast fitting algorithm for non-invasive prostate microstructure characterisation. NMR in Biomedicine 10.1002/nbm.4019 . (In press).

https://ift.tt/2NxhMwp

Lateral parietal contributions to memory impairment in posterior cortical atrophy

Ahmed, S; Loane, C; Bartels, S; Zamboni, G; Mackay, C; Baker, I; Husain, M; ... Butler, C; + view all Ahmed, S; Loane, C; Bartels, S; Zamboni, G; Mackay, C; Baker, I; Husain, M; Thompson, S; Hornberger, M; Butler, C; - view fewer (2018) Lateral parietal contributions to memory impairment in posterior cortical atrophy. NeuroImage: Clinical , 20 pp. 252-259. 10.1016/j.nicl.2018.07.005 . Green open access

https://ift.tt/2DrdbH4

Learning from deaths: Parents' Active Role and ENgagement in The review of their Stillbirth/perinatal death (the PARENTS 1 study)

Bakhbakhi, D; Siassakos, D; Burden, C; Jones, F; Yoward, F; Redshaw, M; Murphy, S; Bakhbakhi, D; Siassakos, D; Burden, C; Jones, F; Yoward, F; Redshaw, M; Murphy, S; Storey, C; - view fewer (2017) Learning from deaths: Parents' Active Role and ENgagement in The review of their Stillbirth/perinatal death (the PARENTS 1 study). BMC Pregnancy and Childbirth , 17 (1) p. 333. 10.1186/s12884-017-1509-z . Green open access

https://ift.tt/2NvZbAu

Omentin-1 protects against bleomycin-induced acute lung injury

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Yan Zhou, CaiXia Hao, Chen Li, XiaoTing Huang, XiaoHong Li, YiTing Tang, YanHong Huang, SiYuan Tang, Wei Liu, DanDan Feng, JianPing Xu, ShaoJie Yue, Hui Xie, ZiQiang Luo

Abstract

Acute lung injury (ALI) is characterized by inflammatory cell infiltration, macrophage activation, and excessive pro-inflammatory cytokine production. Bleomycin (BLM) is widely used to induce acute lung injury (ALI) and fibrosis in murine models. Intratracheally administration of BLM leads to the early stage of inflammatory response and the late stage of collagen deposition. Omentin-1 exerts an anti-inflammatory role in reducing tumor necrosis factor α (TNF-α)-induced cyclooxygenase-2 expression in endothelial cells and attenuating lipopolysaccharide (LPS)-induced ALI. However, the role of omentin-1 in BLM-induced ALI remains unclear. The aim of this study is to examine the effects of omentin-1 on BLM-induced ALI. We found that omentin-1 was decreased in lungs of BLM-induced ALI mice. Omentin-1 overexpression mediated by adenovirus alleviated lung injury and maintained the integrity of the alveolar septa. Omentin-1 overexpression also remarkably decreased the aggregation of neutrophil and macrophages activation, the expression of monocyte chemotactic protein 1 (MCP-1), and down-regulated expression of interleukin 1β (IL-1β) in lungs of BLM-induced ALI mice. Furthermore, we observed that omentin-1 reduced oxidative stress and suppressed the activation of NF-κB pathway in BLM-induced ALI and LPS-induced macrophages activation. Together, our findings indicated that omentin-1 protected mice from BLM-induced ALI may through reducing inflammatory cells recruitment and macrophages activation via alleviation of oxidative stress and NF-κB pathway. Thus, therapeutic strategies aiming to restore omentin-1 levels may be valuable for the prevention of BLM-induced ALI.

https://ift.tt/2O56grc

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

https://ift.tt/2xri65M

GM-CSF intrinsically controls eosinophil accumulation in allergic airway inflammation

Publication date: Available online 20 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Samuel Philip Nobs, Merve Kayhan, Manfred Kopf

Abstract

Background

Eosinophils are a therapeutic target in asthma and GM-CSF has been suggested to control various aspects of eosinophil biology including development, function and survival. However, to date the role of GM-CSF signaling in eosinophils in vivo is largely unclear.

Objective

We sought to elucidate the role of GM-CSF signaling in asthmatic inflammation.

Methods

Wild-type and wild-type alveolar macrophage-reconstituted GM-CSF receptor α (Csf2ra)-deficient mice were subjected to different models of airway inflammation to evaluate the impact of GM-CSF signaling deficiency on asthmatic inflammation in general and on eosinophils in particular

Results

We demonstrate that GM-CSF signaling, while being largely dispensable for eosinophil development in steady-state, intrinsically promotes the accumulation of eosinophils in the lung during allergic airway inflammation. In contrast, chitin-induced eosinophil accumulation in the peritoneal cavity occurs independent of GM-CSF indicating organ specificity. We show that GM-CSF induces chemokinesis and promotes eosinophil survival in vitro, which likely contribute to eosinophil accumulation in the airways in vivo.

Conclusion

GM-CSF is a lung-specific regulator of eosinophil biology in pulmonary allergic inflammation.

Graphical abstract

https://ift.tt/2pqJXhZ

Characterizing drug-induced capillary leak syndromes using the Wold Health Organization VigiBase

Publication date: Available online 20 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Philippe Mertz, Bénédicte Lebrun-Vignes, Joe-Elie Salem, Laurent Arnaud

https://ift.tt/2MQ261P

FPIES: increased prevalence of this great unknown. Results of PREVALE study

Publication date: Available online 20 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): S. Bellón, J. García, P. Torija, S. Díaz, M. Muñoz, P. Alonso, T. Bracamonte, S. Quevedo, L.Á. Echeverría

https://ift.tt/2pqJP1Z

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

https://ift.tt/2xri65M

Oral vitamin D3 5000 IU/day as an adjuvant in the treatment of atopic dermatitis: a randomized control trial

International Journal of Dermatology, EarlyView.


https://ift.tt/2xEIgBc

Gardner‐Diamond syndrome: a systematic review of treatment options for a rare psychodermatological disorder

International Journal of Dermatology, EarlyView.


https://ift.tt/2QNZeFV

Serum irisin: A prognostic marker for severe acne vulgaris

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2xrikK8

SWEET SYNDROME FOLLOWING A POSITIVE MANTOUX TEST DUE TO PULMONARY TUBERCULOSIS

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xBh0n7

Topical diltiazem for ulceration of striae distensae associated with bevacizumab therapy

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2QOVljX

“Chemical” surgery in treating basal cell carcinoma in elderly

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xGEEOS

Lithium and fluoxetine regulate the rate of phosphoinositide synthesis in neurons: a new view of their mechanisms of action in bipolar disorder

Saiardi, A; Mudge, AW; (2018) Lithium and fluoxetine regulate the rate of phosphoinositide synthesis in neurons: a new view of their mechanisms of action in bipolar disorder. Translational Psychiatryvolume , 8 (1) , Article 175 (2018). 10.1038/s41398-018-0235-2 . Green open access

https://ift.tt/2MNjILS

Omic and Systems Biology Approaches in Neurodegenerative Diseases Applying fluid biomarkers to Alzheimer's disease

Zetterberg, H; (2017) Omic and Systems Biology Approaches in Neurodegenerative Diseases Applying fluid biomarkers to Alzheimer's disease. American Journal of Physiology - Cell Physiology , 313 (1) C3-C10. 10.1152/ajpcell.00007.2017 . Green open access

https://ift.tt/2ppb2C2

Parental age and offspring leukocyte telomere length and attrition in midlife: Evidence from the 1946 British birth cohort

Wulaningsih, W; Hardy, R; Wong, A; Kuh, D; (2018) Parental age and offspring leukocyte telomere length and attrition in midlife: Evidence from the 1946 British birth cohort. Experimental Gerontology , 112 pp. 92-96. 10.1016/j.exger.2018.09.008 . (In press). Green open access

https://ift.tt/2MPpFbf

Eric A Barnard FRS (1927 -2018)

Dolly, JO; Henley, JM; Stephenson, FA; (2018) Eric A Barnard FRS (1927 -2018). J Neurochem 10.1111/jnc.14584 . (In press).

https://ift.tt/2psqTQ8

The role of storytelling in innovation process

Sergeeva, N; Trifilova, A; (2018) The role of storytelling in innovation process. Creativity and Innovation Management (In press).

https://ift.tt/2MTLkPD

The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics

Barbieri, CE; Chinnaiyan, AM; Lerner, SP; Swanton, C; Rubin, MA; (2017) The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics. European Urology , 71 (2) pp. 237-246. 10.1016/j.eururo.2016.08.024 . Green open access

https://ift.tt/2psqTzC

Championing and promoting innovation in UK megaprojects

Sergeeva, N; Zanello, C; (2018) Championing and promoting innovation in UK megaprojects. International Journal of Project Management (In press).

https://ift.tt/2MQNoYy

Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution

Giannoni, L; Lange, F; Davies, AL; Dua, A; Gustavson, B; Smith, KJ; Tachtsidis, I; (2018) Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution. Advances in Experimental Medicine and Biology , 1072 pp. 13-20. 10.1007/978-3-319-91287-5_3 . Green open access

https://ift.tt/2poP3uS

Small- and large-amplitude oscillatory rheometry with bead-spring dumbbells in Stokesian Dynamics to mimic viscoelasticity

Townsend, AK; Wilson, HJ; (2018) Small- and large-amplitude oscillatory rheometry with bead-spring dumbbells in Stokesian Dynamics to mimic viscoelasticity. Journal of Non-Newtonian Fluid Mechanics (In press).

https://ift.tt/2MTtOuG

The mechanism of force transmission at bacterial focal adhesion complexes

Faure, LM; Fiche, J-B; Espinosa, L; Ducret, A; Anantharaman, V; Luciano, J; Lhospice, S; ... Mignot, T; + view all Faure, LM; Fiche, J-B; Espinosa, L; Ducret, A; Anantharaman, V; Luciano, J; Lhospice, S; Islam, ST; Treguier, J; Sotes, M; Kuru, E; Van Nieuwenhze, MS; Brun, YV; Theodoly, O; Aravind, L; Nollmann, M; Mignot, T; - view fewer (2016) The mechanism of force transmission at bacterial focal adhesion complexes. Nature , 539 (7630) pp. 530-535. 10.1038/nature20121 . Green open access

https://ift.tt/2pnzQdM

The role of neutrophils in the pathogenesis of Crohn's disease

Segal, AW; (2018) The role of neutrophils in the pathogenesis of Crohn's disease. European Journal of Clinical Investigation 10.1111/eci.12983 . (In press).

https://ift.tt/2MRXgBc

ATHENA X-IFU thermal filters development status toward the end of the instrument phase-A

Barbera, M; Lo Cicero, U; Sciortino, L; D'Anca, F; Lo Cicero, G; Parodi, G; Sciortino, S; ... Piro, L; + view all Barbera, M; Lo Cicero, U; Sciortino, L; D'Anca, F; Lo Cicero, G; Parodi, G; Sciortino, S; Rauw, G; Branduardi-Raymont, G; Varisco, S; Ferruggia Bonura, S; Collura, A; Candia, R; DI Cicca, G; Giglio, P; Buttacavoli, A; Cuttaia, F; Villa, F; Cappi, M; Lam Trong, T; Mesnager, JM; Peille, P; Den Hartog, R; Den Herder, JW; Jackson, B; Barret, D; Piro, L; - view fewer (2018) ATHENA X-IFU thermal filters development status toward the end of the instrument phase-A. In: Proceedings of Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray. (pp. 106991R-1-106991R-15). SPIE: Austin, TX, United States. Green open access

https://ift.tt/2pnzGDc

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

Amos, CI; Dennis, J; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; ... Easton, DF; + view all Amos, CI; Dennis, J; Wang, Z; Byun, J; Schumacher, FR; Gayther, SA; Casey, G; Hunter, DJ; Sellers, TA; Gruber, SB; Dunning, AM; Michailidou, K; Fachal, L; Doheny, K; Spurdle, AB; Li, Y; Xiao, X; Romm, J; Pugh, E; Coetzee, GA; Hazelett, DJ; Bojesen, SE; Caga-Anan, C; Haiman, CA; Kamal, A; Luccarini, C; Tessier, D; Vincent, D; Bacot, F; Van Den Berg, DJ; Nelson, S; Demetriades, S; Goldgar, DE; Couch, FJ; Forman, JL; Giles, GG; Conti, DV; Bickeböller, H; Risch, A; Waldenberger, M; Brüske-Hohlfeld, I; Hicks, BD; Ling, H; McGuffog, L; Lee, A; Kuchenbaecker, K; Soucy, P; Manz, J; Cunningham, JM; Butterbach, K; Kote-Jarai, Z; Kraft, P; FitzGerald, L; Lindström, S; Adams, M; McKay, JD; Phelan, CM; Benlloch, S; Kelemen, LE; Brennan, P; Riggan, M; O'Mara, TA; Shen, H; Shi, Y; Thompson, DJ; Goodman, MT; Nielsen, SF; Berchuck, A; Laboissiere, S; Schmit, SL; Shelford, T; Edlund, CK; Taylor, JA; Field, JK; Park, SK; Offit, K; Thomassen, M; Schmutzler, R; Ottini, L; Hung, RJ; Marchini, J; Amin Al Olama, A; Peters, U; Eeles, RA; Seldin, MF; Gillanders, E; Seminara, D; Antoniou, AC; Pharoah, PDP; Chenevix-Trench, G; Chanock, SJ; Simard, J; Easton, DF; - view fewer (2017) The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiology, Biomarkers and Prevention , 26 (1) pp. 126-135. 10.1158/1055-9965.EPI-16-0106 . Green open access

https://ift.tt/2MOaBdH

Timing temporal transitions during brain development

Rossi, AM; Fernandes, VM; Desplan, C; (2017) Timing temporal transitions during brain development. Current Opinion in Neurobiology , 42 pp. 84-92. 10.1016/j.conb.2016.11.010 . Green open access

https://ift.tt/2pt2LNC

Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study

Rubin, LH; Benning, L; Keating, SM; Norris, PJ; Burke-Miller, J; Savarese, A; Kumanan, KN; ... Maki, PM; + view all Rubin, LH; Benning, L; Keating, SM; Norris, PJ; Burke-Miller, J; Savarese, A; Kumanan, KN; Awadalla, S; Springer, G; Anastos, K; Young, M; Milam, J; Valcour, VG; Weber, KM; Maki, PM; - view fewer (2017) Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study. Journal of NeuroVirology , 24 (1) pp. 41-51. 10.1007/s13365-017-0590-4 . Green open access

https://ift.tt/2MQNkbg

ATHENA WFI optical blocking filters development status toward the end of the instrument phase-A

Barbera, M; Lo Cicero, U; Sciortino, L; D'Anca, F; Parodi, G; Rataj, M; Polak, S; ... Candia, R; + view all Barbera, M; Lo Cicero, U; Sciortino, L; D'Anca, F; Parodi, G; Rataj, M; Polak, S; Pilch, A; Meidinger, N; Sciortino, S; Rauw, G; Branduardi Raymont, G; Mineo, T; Perinati, E; Giglio, P; Collura, A; Varisco, S; Candia, R; - view fewer (2018) ATHENA WFI optical blocking filters development status toward the end of the instrument phase-A. In: Proceedings of Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray. (pp. 106991K-1-106991K-13). SPIE Green open access

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A Randomized Trial of Early Endovenous Ablation in Venous Ulceration: a critical appraisal

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


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