Beuthe, TP; (2016) Seals and sealing practices in early administration in southwestern Asia and Egypt during the fourth to third millennium BCE. Doctoral thesis, UCL (University College London).
http://ift.tt/2f3F0Us
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Πέμπτη 17 Νοεμβρίου 2016
Seals and sealing practices in early administration in southwestern Asia and Egypt during the fourth to third millennium BCE
Analysis of Key Drivers of Trading Performance
Batrinca, B; (2016) Analysis of Key Drivers of Trading Performance. Doctoral thesis, UCL (University College London).
http://ift.tt/2gjOrEu
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
Nixon-Abell, J; Obara, CJ; Weigel, AV; Li, D; Legant, WR; Xu, CS; Pasolli, HA; Nixon-Abell, J; Obara, CJ; Weigel, AV; Li, D; Legant, WR; Xu, CS; Pasolli, HA; Harvey, K; Hess, HF; Betzig, E; Blackstone, C; Lippincott-Schwartz, J; - view fewer (2016) Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. Science , 354 (6311) , Article 433. 10.1126/science.aaf3928 . Green open access
http://ift.tt/2f3AEwE
Proteomics of Sub-cellular Protein Distribution in Oestrogen and Tamoxifen Stimulated MCF-7 Breast Cancer Cells
Alkhanjaf, AAM; (2016) Proteomics of Sub-cellular Protein Distribution in Oestrogen and Tamoxifen Stimulated MCF-7 Breast Cancer Cells. Doctoral thesis, UCL (University College London).
http://ift.tt/2gjTvsH
Determinants of sickness absence and early retirement intentions and the relationship between sickness absence and the risk of disability retirement or early retirement intentions in the Abu Dhabi Police
Alkaabi, F; (2016) Determinants of sickness absence and early retirement intentions and the relationship between sickness absence and the risk of disability retirement or early retirement intentions in the Abu Dhabi Police. Doctoral thesis, UCL (University College London).
http://ift.tt/2f3H4Mv
Assessment of physical activity in COPD patients in the stable state and during exacerbation and recovery
Al Ahmari, ADA; (2016) Assessment of physical activity in COPD patients in the stable state and during exacerbation and recovery. Doctoral thesis, UCL (University College London).
http://ift.tt/2gjS9OA
The qualities and practices of effective system leaders: primary headteachers
Wilkinson, S; (2016) The qualities and practices of effective system leaders: primary headteachers. Doctoral thesis, UCL (University College London). Green open access
http://ift.tt/2f3D2DD
Education in the midst of Greece's socio-economic crisis. Is there room for new stories, another way of thinking and a notion of hope?
Chalari, M; (2016) Education in the midst of Greece's socio-economic crisis. Is there room for new stories, another way of thinking and a notion of hope? Doctoral thesis, UCL (University College London). Green open access
http://ift.tt/2gjQSHg
Global citizenship and global school-links: perceptions from Tobago and the United Kingdom
Allen, YV; (2016) Global citizenship and global school-links: perceptions from Tobago and the United Kingdom. Doctoral thesis, UCL (University College London).
http://ift.tt/2f3J8Ut
The effect of temperature uncertainty on Proton Exchange Fuel Cell (PEFC) performance
Noorkami, M; (2016) The effect of temperature uncertainty on Proton Exchange Fuel Cell (PEFC) performance. Masters thesis, UCL (University College London). Green open access
http://ift.tt/2gjOuA2
Evaluating and optimising glaucoma referral refinement pathways with specific reference to the changes scheme
Ratnarajan, G; (2016) Evaluating and optimising glaucoma referral refinement pathways with specific reference to the changes scheme. Doctoral thesis, UCL (University College London).
http://ift.tt/2f3CEVN
Advanced radiation therapies for meningioma
Maclean, JD; (2016) Advanced radiation therapies for meningioma. Doctoral thesis, UCL (University College London). Green open access
http://ift.tt/2gjMMPc
Formation and electrocatalysis studies of nickel and iron sulfide catalysts using in situ XAS
Islam, H-U; (2016) Formation and electrocatalysis studies of nickel and iron sulfide catalysts using in situ XAS. Doctoral thesis, UCL (University College London). Green open access
http://ift.tt/2f3Kte8
Development and testing of a biologic dosimentric phantom for proton and ion beam therapy
Viana Miranda Lima, T; (2016) Development and testing of a biologic dosimentric phantom for proton and ion beam therapy. Doctoral thesis, UCL (University College London).
http://ift.tt/2gjQw37
Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy
Abstract
Introduction
Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating neoantigens. In this study, we aim to investigate the HLA class I expression, PD-L1 and tumour-infiltrating lymphocytes in primary osteosarcomas and relapses/metastases, as well as their changes during disease progression.
Materials and methods
Tumour samples from multiple stages of the disease (pretreatment biopsies, surgical resections of primary osteosarcomas, relapses and metastases) were collected and stained for HLA-A (HCA2), HLA-B/C (HC10), β2-microglobulin and PD-L1 using immunohistochemistry on whole sections. Density and type of T-cell infiltrate were characterised by a triple immunofluorescent staining CD3-CD8-FOXP3.
Results
Overall, 85 formalin-fixed, paraffin-embedded blocks from 25 osteosarcoma patients were included. HLA class I expression was detected in 94% of osteosarcomas (strongly positive in 56%, heterogeneous in 38%) and negative or weakly positive in 6%, without differences between the stages of the disease. HLA-A expression was more frequently negative than HLA-B/C. Tumour-infiltrating lymphocytes were highly heterogeneous and mainly observed in tumour areas with expression of HLA class I. Density of T cells was significantly higher in metastases than in primary tumours and local relapses (p = 0.0003). Positive PD-L1 expression was found in 13% of primary tumours, 25% of relapses and 48% of metastases and correlated with a high T-cell infiltrate (p = 0.002).
Conclusion
An increased number of tumour-infiltrating T cells and PD-L1 expression in metastases compared with primary tumours, suggesting accessibility for T cells, could imply that osteosarcoma patients with metastatic disease may benefit from T-cell-based immunotherapy.
http://ift.tt/2eJkzB8
Engaged visual art as a tool for normative renewal in international human rights: the case of Ariella Azoulay’s potential history (2012)
This contribution is a first attempt at collaboration between an art researcher, Hilde Van Gelder, and a scholar of human rights law, Eva Brems, which we hope will develop into a fully fledged research project. In the first part of the chapter, Hilde Van Gelder shows how Ariella Azoulay ' s artistic and curatorial work leads to her theoretical positions on human rights, that is, how visual art talks to international human rights law in this case, and what it has to say. In the second part, Eva Brems explores whether and how international human rights law can rise to the challenge of, and address, the claims put forward by the artist and art researcher.
http://ift.tt/2fYJePw
Aangifte vennootschapsbelasting aj 2016
Seminarie omtrent actuele aspecten van de vennootschapsbelasting in 2016
http://ift.tt/2glvSAG
European comparison of procedures and practices for the implementation in European union of an integrated administrative and criminal strategy to fight vat tax frauds
Comparison of national procedures against VAT tax fraud
http://ift.tt/2glt3zt
Fiscale infoclub januari 2016
Fiscale actualiteit programmawetten dec/jan 2016
http://ift.tt/2glucqW
Faecal (meta)proteomics: A tool to investigate dysbiosis and inflammation in patients with cystic fibrosis
Cystic fibrosis is a genetic disease caused by mutation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein. The disease is mostly associated with severe lung pathogenesis typically caused by infection by Pseudomonas aeruginosa. However, many patients also suffer from intestinal complications. The primary cause is pancreas insufficiency resulting in decreased release of digestive enzymes which is typically cured by enzyme replacement therapy. However, sticky mucus formation and repetitive antibiotic treatment have a severe affect on the gut microcbiota. Several microbial studies indeed reported gut microbiota dysbiosis in patients with cystic fibrosis (CF). However, the functional consequences of this phenomenon are poorly understood. We analysed faecal protein extracts from fifteen patients with CF that have pancreatic insufficiency and from their unaffected siblings by shotgun proteomics. Novel computational and statistical tools, among which the novel Unipept tool were introduced to evaluate changes in taxonomic composition and protein abundance. Faecal protein extracts from patients with CF were dominated by host proteins involved in inflammation and mucus formation. Taxonomic analysis of the microbial proteins confirmed the strong reduction of butyrate reducers such as Faecalibacterium prausnitzii and increase of Enterobacteriaceae, Ruminococcus gnavus and Clostridia species. Our work showed that faecal metaproteomics provides insights in intestinal dysbiosis, inflammation in patients with CF and can be used to monitor different disease markers in parallel.
http://ift.tt/2fYG2TT
Development and characterization of composites consisting of woven fabrics with integrated prismatic shaped cavities
Composites are extensively used in automotive, construction, airplanes, wind turbines etc. because of their good mechanical properties such as high specific stiffness, high specific strength and resistance against fatigue. The main issues with composites are delamination and the manual labour in the production process. If hollow structures like stiffeners need to be manufactured, these problems become even more apparent. As a result, there is a lot of interest in woven fabrics with integrated prismatic shaped cavities for composites as they reduce the manual labour, have a higher resistance against delamination and can lead to special properties and applications. In this work several of these woven fabrics with integrated prismatic shaped cavities are designed and produced in high-tenacity polyester yarns. Then, the possibility to use these fabrics in composites is explored: reproducibility of the production process is assessed and static testing is performed. A reproducible production process is developed and static testing shows promising results.
http://ift.tt/2gltGsJ
The association between human papillomavirus and oropharyngeal squamous cell Carcinoma
Source:Oral Oncology, Volume 63
Author(s): Lena Walvik, Amanda Björk Svensson, Jeppe Friborg, Christel Bræmer Lajer
There is emerging evidence of the association between human papillomavirus and a subset of head and neck cancers. However, the role of human papillomavirus as a causal factor is still debated. This review addresses the association between human papillomavirus and oropharyngeal squamous cell carcinoma using the Bradford Hill criteria. The strength of the association is supported by, detection of human papillomavirus infection and antibodies prior to oropharyngeal squamous cell carcinoma. This is furthermore reinforced by the absence of human papillomavirus DNA in healthy tonsils. The association is geographically consistent throughout the economically developed world. The presence and integration of high-risk human papillomavirus genome in tonsillar tumours, and expression of viral oncogenes, are specific and plausible. Analogous to human papillomavirus in cervical cancer, the rising incidence in human papillomavirus positive oropharyngeal squamous cell carcinoma is associated with sexual behaviour. These associations have been repeatedly observed and are in accordance with our current knowledge. The time relation between cause and effect remains the main challenge, due to the lack of well-defined premalignant lesions. However, a causal relationship between human papillomavirus infection and oropharyngeal squamous cell carcinoma seems evident.
http://ift.tt/2g00Eh5
A comparison of mandible preservation method and mandibulotomy approach in oral and oropharyngeal cancer: A meta-analysis
Source:Oral Oncology, Volume 63
Author(s): Pai Pang, Rui-Wu Li, Jing-Pu Shi, Zhong-Fei Xu, Wei-Yi Duan, Fa-Yu Liu, Shao-Hui Huang, Xue-Xin Tan, Chang-Fu Sun
ObjectiveThis study aims to compare the prognoses outcomes of mandibular preservation method (MPM) and the mandibulotomy approach (MLA) in oral and oropharyngeal cancer (OOPC) patients.MethodWe searched PubMed, Web of Science, EMBASE, Chinese BioMedical Literature Database (CBM), Cochrane Library, and clinicaltrials.gov up to September 2016 to identify the studies that compared the prognoses of the MPM versus the MLA in OOPC patients. Two authors individually extracted the data and performed quality assessment. The surgical margins, overall survival rate, total and local recurrence rates, fistula formation, and other functional outcomes were evaluated.ResultSix studies with 309 patients were included in our analysis. No significant difference was found regarding the surgical margins, overall survival rate, total and local recurrence rates, and speech and tongue movement between the MPM and MLA groups. However, the MPM group showed a significantly lower fistula formation rate than the MLA group after the operation.ConclusionThese findings suggest that the MPM may provide a similar clinical outcome to the MLA, but that the MPM has a lower complication rate in the treatment of OOPC patients.
http://ift.tt/2fIet0I
Editorial Board/Aims & Scope
Source:Oral Oncology, Volume 62
http://ift.tt/2g003Mo
Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia
We present an infant with acute fever, thrombocytopenia, and leukopenia, coming from an endemic region for tick-borne encephalitis, human granulocytic anaplasmosis, and hantavirus infection. The primary human herpesvirus 6 infection was diagnosed by seroconversion of specific IgM and IgG and by identification of viral DNA in the acute patient's serum. The patient did not show skin rash suggestive of exanthema subitum during the course of illness.
http://ift.tt/2f31FQZ
Mid-pregnancy and cord blood immunological biomarkers, HLA genotype and pediatric celiac disease
Source:Journal of Allergy and Clinical Immunology
Author(s): Karl Mårild, Maria Vistnes, German Tapia, Øivind Midttun, Per M. Ueland, Marte K. Viken, Per Magnus, Jens P. Berg, Lars C. Stene, Ketil Størdal
Teaser
Capsule summary: This first investigation of multiple biomarkers reflecting cellular and humoral immune activation in mid-pregnancy or at birth do not support concerns that the prenatal systemic immune response influences celiac disease development in children.http://ift.tt/2fYJkVT
Human regulatory B cells control Tfh response
Publication date: Available online 16 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Achouak Achour, Quentin Simon, Audrey Mohr, Jean-François Séité, Pierre Youinou, Boutahar Bendaoud, Ibtissem Ghedira, Jacques-Olivier Pers, Christophe Jamin
BackgroundFollicular helper T (Tfh) cells support the terminal B-cell differentiation. Human regulatory B (Breg) cells modulate cellular responses but their control of Tfh-dependent humoral immune responses is unknown.ObjectiveTo assess the role of Breg cells on Tfh development and function.MethodsHuman T cells were polyclonally stimulated in the presence of IL-12 and IL-21 to generate Tfh cells. They were co-cultured with B cells to induce their terminal differentiation. Breg cells were included in these cultures and their effects evaluated using flow cytometry and ELISA.ResultsBcl-6, IL-21, ICOS, CXCR5 and PD-1 expressions increased on stimulated human T cells, characterizing Tfh-cell maturation. In co-cultures, they differentiated B cells into CD138+ plasma and IgD-CD27+ memory cells, and triggered immunoglobulin secretions. Breg cells obtained by TLR9 and CD40 activation of B cells, prevented Tfh-cell development. Added to Tfh and B cells co-cultures, they inhibited the B-cell differentiation, impeded immunoglobulin secretions, and expanded Foxp3+CXCR5+PD-1+ follicular regulatory T (Tfr) cells. Breg cells modulated IL-21R expressions on Tfh cells and B cells, their suppressive activities involved CD40, CD80, CD86, and ICAM interactions and required production of IL-10 and TGFβ.ConclusionHuman Breg cells control the Tfh-cell maturation, expand Tfr cells and inhibit the Tfh-mediated antibody secretion. These novel observations demonstrate a role for the Breg in the germinal center reactions and suggest that deficient activities may impair the Tfh-dependent control of humoral immunity and may lead to the development of aberrant autoimmune responses.
Graphical abstract
Teaser
Our study describes in vitro models assessing the role of human regulatory B cells to modulate Tfh cell development and function and hence, to control the humoral immune response.http://ift.tt/2fYMzwB
Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice
Publication date: Available online 16 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Benedikt Fritzsching, Matthias Hagner, Lu Dai, Sandra Christochowitz, Raman Agrawal, Charlotte van Bodegom, Simone Schmidt, Jolanthe Schatterny, Stephanie Hirtz, Ryan Brown, Michelle Goritzka, Julia Duerr, Zhe Zhou-Suckow, Marcus A. Mall
BackgroundType 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. We recently demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in juvenile Scnn1b-transgenic (Scnn1b-Tg) mice.ObjectiveTo determine the role of impaired mucus clearance in the pathogenesis of allergen-induced type 2 airway inflammation and identify cellular sources of the signature cytokine IL-13.MethodsWe challenged juvenile Scnn1b-Tg and wild-type mice with Aspergillus fumigatus and house dust mite allergen and compared effects on airway eosinophilia, type 2 cytokine levels, goblet cell metaplasia and airway hyperresponsiveness. Further, we determined cellular sources of IL-13 and effects of genetic deletion of the key type 2 signal transducing molecule STAT6, and evaluated effects of therapeutic improvement of mucus clearance.ResultsReduced mucociliary allergen clearance exacerbated Stat6-dependent secretion of type 2 cytokines, airway eosinophilia and airway hyperresponsiveness in juvenile Scnn1b-Tg mice. IL-13 was elevated in airway epithelial cells, macrophages, type 2 innate lymphoid cells and Th2 cells along with increased Il33 in the airway epithelium of Scnn1b-Tg mice. Treatment with the epithelial Na+ channel blocker amiloride improving airway surface hydration and mucus clearance reduced allergen-induced inflammation in Scnn1b-Tg.ConclusionOur data support that impaired clearance of inhaled allergen triggering IL-13 production by multiple cell types in the airways plays an important role in the pathogenesis of type 2 airway inflammation and suggest therapeutic improvement of mucociliary clearance as a novel treatment strategy for children with allergen-induced asthma.
Graphical abstract
Teaser
This study identifies impaired mucus clearance as a risk factor for allergen-induced type 2 airway inflammation in mice and suggests that pharmacological improvement of mucociliary clearance may be an effective treatment strategy for allergic asthma.http://ift.tt/2fYK8u7
Protocadherin-1 localization and cell-adhesion function in airway epithelial cells in asthma
Background : The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the localization, differential expression, homotypic adhesion specificity and function of PCDH1 in airway epithelial cells in asthma. Methods : We performed confocal fluorescence microscopy to determine subcellular localization of PCDH1 in 16HBE cells and primary bronchial epithelial cells (PBECs) grown at air-liquid interface. Next, to compare PCDH1 expression and localization in asthma and controls we performed qRT-PCR and fluorescence microscopy in PBECs and immunohistochemistry on airway wall biopsies. We examined homotypic adhesion specificity of HEK293T clones overexpressing fluorescently tagged-PCDH1 isoforms. Finally, to evaluate the role for PCDH1 in epithelial barrier formation and repair, we performed siRNA knockdown-studies and measured epithelial resistance. Results : PCDH1 localized to the cell membrane at cell-cell contact sites, baso-lateral to adherens junctions, with increasing expression during epithelial differentiation. No differences in gene expression or localization of PCDH1 isoforms expressing the extracellular domain were observed in either PBECs or airway wall biopsies between asthma patients and controls. Overexpression of PCDH1 mediated homotypic interaction, whereas downregulation of PCDH1 reduced epithelial barrier formation, and impaired repair after wounding. Conclusions : In conclusion, PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Expression of PCDH1 is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair.
http://ift.tt/2fYKzVh
Extended versus bolus infusion of meropenem and piperacillin: a pharmacokinetic analysis
Background. Extended infusion of beta-lactam antibiotics has been advocated as a method for optimizing antibiotic exposure in critically ill patients. The objective of this study was to compare the pharmacokinetics/pharmacodynamics of extended infusion versus bolus infusion of piperacillin and meropenem in critically ill patients with normal renal function. Methods. A prospective study of 3 hours extended infusion of meropenem and piperacillin in critically ill patients without renal dysfunction. Results from the extended infusion cohort were compared to previously published bolus infusion data in critically ill patients. Results. Twenty extended infusion patients (15 piperacillin, 5 meropenem) were compared with 13 bolus infusion patients (8 piperacillin, 5 meropenem). The demographic and clinical characteristics between both groups were not statistically different. Significant pharmacokinetic differences were observed in median (interquartile range) C-max for both meropenem (extended infusion 17 [12.6-21.9] vs. bolus 85.2 [66.7-140.3]; P=0.01) and piperacillin (extended infusion 76.2 [57.7-92.6] vs. bolus 240.2 [168.5-275.4]; P=0.001). Considerable pharmacokinetic variability existed in each group for both drugs. Compared to bolus infusion, f Gamma(>MIC) using extended infusion was higher for both drugs: 96% (IQR 71-100%) compared to 77% (IQR 41-93%) for piperacillin (P=0.05) and 82% (IQR 63-89%) compared to 51% (IQR 48-63%) for meropenem (P=0.095); assuming a MIC of 16 mg/L and 2 mg/L respectively. Conclusion. This study confirms that extended infusion in critically ill patients result in advantageous pharmacokinetic profiles by increasing the f Gamma(>MIC) for piperacillin and meropenem. In a significant subpopulation of critically ill patients with normal renal function, a 100% f Gamma(>MIC) target is not reached, even with 3-hour extended infusions.
http://ift.tt/2f7jim0
Giant rhinolith: A case report
Publication date: Available online 16 November 2016
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Author(s): Khairul Bariah Noh, Ida Sadjaah Sachlin, Norzi Gazali, Norasnieda Md Shukri
Rhinolith is a stone that form in the nose. It is an uncommon disease that may present asymptomatically. It is usually occur secondary to retained foreign bodies. Sometimes, it can be cause by fungal infection. It can be seen on radiographs as a radiopaque object in the nasal fossa and may be confused with several pathologic entities that will call for more invasive surgical procedures. Here we present a case of giant rhinolith possibly arising from retained foreign body, and discuss its clinical and radiologic features.
http://ift.tt/2f3n7Fq
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted therapies available. This is, in part, due to the lack of highly penetrant and rapid retinoblastoma animal models that facilitate rapid identification of targets that allow therapeutic intervention. Different mouse models are available, all based on genetic deactivation of both Rb1 and Retinoblastoma-like 1 (Rbl1), and each showing different kinetics of retinoblastoma development. Here, we show by CRISPR/Cas9 techniques that similar to the mouse, neither rb1 nor rbl1 single mosaic mutant Xenopus tropicalis develop tumors, whereas rb1/rbl1 double mosaic mutant tadpoles rapidly develop retinoblastoma. Moreover, occasionally presence of pinealoblastoma (trilateral retinoblastoma) was detected. We thus present the first CRISPR/Cas9 mediated cancer model in Xenopus tropicalis and the first genuine genetic non-mammalian retinoblastoma model. The rapid kinetics of our model paves the way for use as a pre-clinical model. Additionally, this retinoblastoma model provides unique possibilities for fast elucidation of novel drug targets by triple multiplex CRISPR/Cas9 gRNA injections (rb1 + rbl1 + modifier gene) in order to address the clinically unmet need of targeted retinoblastoma therapy.
http://ift.tt/2fjDVJl
Efficient multi-objective optimization of wireless network problems on wireless testbeds
A large amount of research focuses on experimentally optimizing performance of wireless solutions. Finding the optimal performance settings typically requires investigating all possible combinations of design parameters, while the number of required experiments increases exponentially for each considered design parameter. The aim of this paper is to analyze the applicability of global optimization techniques to reduce the optimization time of wireless experimentation. In particular, the paper applies the Efficient Global Optimization (EGO) algorithm implemented in the SUrrogate MOdeling (SUMO) toolbox inside a wireless testbed. The proposed techniques are implemented and evaluated in a wireless testbed using a realistic wireless conference network problem. The performance accuracy and experimentation time of an exhaustively searched experiment is compared against a SUMO optimized experiment. In our proof of concept, the proposed SUMO optimizer reaches 99.51% of the global optimum performance while requiring 10 times less experiments compared to the exhaustive search experiment.
http://ift.tt/2eJ3x62
Diverse influence factors on the range of electric vehicles
Electric vehicles of today can be designed with high efficiency drives and drivetrains. This means that the aerodynamic drag, the tire losses and auxiliary equipment have an increasing influence on the range of the vehicle. Moreover, the user will experience "his range" in a single direction from A to B, rather than averaged. The rolling resistance and the drag force are not constants but temperature dependent. Effects of wind, rain and altitude change are also evaluated. Such factors are not included in typical driving cycle tests, but are important for the real range of the vehicle.
http://ift.tt/2fjKXOe
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