Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Primary small cell neuroendocrine carcinoma is uncommon in head and neck region, with occasional cases in nasopharynx. Distinction from other round cell tumors is imperative to ensure optimal patient management. We present a case of a 30-year-old woman who presented with a rapidly growing nasopharyngeal mass.
Kawaljit Kaur | Milica Perišic Nanut | Meng-Wei Ko | Tahmineh Safaie | Janko Kos | Anahid Jewett
https://ift.tt/2HuVPb0
Background. We hypothesized that anti-thyroid antibodies are more often positive in individuals with deranged thyroid profile. Methods. This prospective cohort was done in Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Jan 2017 to Oct 2017. All the samples that were referred to us for testing anti-thyroid antibodies (anti-TPO or anti-TG antibodies) and thyroid profile were included in the study. There were no exclusion criteria. Tests for anti-thyroid antibodies were performed by ELISA and thyroid profile by chemiluminescence. SPSS 23.0 was used for statistical analysis. Results. Over a course of a ten-month study period, we received a total of 316 serum samples for anti-TPO/TG antibodies along with thyroid profile testing (TSH). These included 115 males (36.4%) and 201 females (63.6%). Their age ranged from 3 to 89 years (mean ± SD, 42.22 ± 18.09). Anti-TPO antibodies were more often positive when TSH was deranged ( value 0.001). Anti-TPO antibodies are more often raised in females, in terms of both prevalence ( 0.001) and mean rank ( 0.002). Conclusion. As anti-thyroid antibodies are more often present when TSH is deranged, such individuals should be screened for anti-thyroid antibodies. This importance of screening is compounded by the fact that anti-thyroid antibodies may be positive in a significant percentage of elderly people.
https://ift.tt/2qomXjO
To evaluate the prevalence of middle ear disease in infants referred for failed newborn hearing screening (NBHS) and to review patient outcomes after intervention in order to propose an evidence-based protocol for management of newborns with otitis media with effusion (OME) who fail NBHS.
https://ift.tt/2GQX3jN
In a study in The New England Journal of Medicine, NCI researchers identified genetic subtypes of diffuse large B-cell lymphoma (DLBCL), the most common type of lymphoma, that could help explain why some patients with the disease respond to treatment and others don't.
Description
A previously healthy, non-asthmatic, non-smoker, 16-year-old male came for medical attention because of odynophagia and pain located at anterior cervical area and upper retrosternal area, increasing with swallowing and deep breathing, that begun after physical exercise at gymnastic class. The adolescent also mentioned a felling of air bubbles running up and down that area. There was no history of local trauma. He referred stuffed nose and mild cough but no other respiratory complaints or fever. Physical examination was unremarkable, with normal auscultation and no alterations on cervical and thoracic examination. Lateral soft tissue neck X-ray revealed free air in retropharyngeal space (figure 1, arrows). Chest X-ray showed a small amount of air in the upper mediastinum. Blood count was normal, and C reactive protein was negative. Mycoplasma pneumoniae IgM was negative. The patient was treated with high concentration oxygen and oral analgesia. The next day, he...
Food-dependent exercise-induced anaphylaxis (FDEIAn), first reported in 1979, is a condition defined by the consumption of a trigger food with temporally related exercise that results in an immediate hypersensitivity (type 1) reaction in the setting of the trigger food being tolerated independent of exercise and exercise being tolerated in the absence of trigger food consumption. The most common trigger food in the west is wheat and shellfish in Asia. The exact mechanism of FDEIAn is unknown, though several hypotheses exist. Cofactors such as non-steroidal anti-inflammatory drug use, alcohol consumption and others have been associated with reported cases.
Description
A 30-year-old male patient underwent percutaneous nephrolithotomy (PCNL) for a 3.5 cm right renal calculus. As per our institutional protocol he underwent a check X-ray the next day. The relatives of the patient immediately came to us asking whether some residual fragments of the calculus were there in the urinary bladder. When we reviewed the X-ray film, there was a radio-opaque shadow with a smooth contour in the region of urinary bladder. On careful examination this shadow was continuous with a radio-opaque line along the Foley catheter (figure 1). We immediately removed the Foley catheter and did another check X-ray. The shadow had disappeared. We then realised that the catheter's balloon was inflated with contrast solution prepared for fluoroscopy-guided puncture during PCNL. We acknowledged this error to the patient and his relatives and explained them how sorry we were for their anxiety, following which they were...
Some ankle sprains hide important lesions beyond the classic lateral ligament complex injuries. The lateral inverted osteochondral fracture of the talus (LIFT) represents a rare osteochondral lesion, whose diagnosis relies on a high clinical suspicion followed by correct image study interpretation. We present a successful arthroscopic fixation of a LIFT lesion in a 45-year-old active man. At 8 months follow-up, the patient was pain free and able to return to his daily activities without limitation. The imagiological study showed osteochondral fragment consolidation with no signs of hardware failure. This midterm results reassemble the need for early diagnosis and correct treatment to achieve a good outcome in these complex and rare osteochondral lesions.
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour. A diagnosis of a metastatic lobular carcinoma of the breast (T0, N1, M1) was made and the patient was started on chemotherapy and adjuvant hormonal therapy.
We present a challenging case of a previously healthy 23-year-old man who developed an inflammatory myofibroblastic tumour of the hard palate, harbouring a rearrangement of the anaplastic lymphoma kinase (ALK) locus. Despite surgical intervention, radiotherapy and ALK-inhibition therapy, the tumour recurred locally and metastasised to regional lymph nodes, and the patient passed away roughly 9 months after diagnosis from local progression. The rapid progression of this patient's disease and its resistance to treatment demonstrate the potentially aggressive clinical course of inflammatory myofibroblastic tumours. ALK-inhibition therapy was unsuccessful in this ALK-positive tumour, highlighting the need for further investigation of markers predictive of disease progression and treatment response.
Empyema secondary to foreign body aspiration is rare in adults. We present a case of empyema in a 77-year-old male patient related to a remote aspiration event during a dental procedure. A CT of the chest and bronchoscopy confirmed that a metallic foreign body was located within the right lower lobe bronchus. His pleural fluid culture revealed Sphingomonas paucimobilis which is a low-virulent opportunistic gram-negative bacilli and rarely causes infection. The patient received meropenem followed by levofloxacin and recovered uneventfully. The attempt of foreign body removal was failed due to chronic inflammation, and the patient refused further surgical management.
Description
The peripherally inserted central catheter (PICC) is used as a long-term vascular access to deliver medications and venous nutrition. The PICC tip terminates close to the heart or in one of the great vessels—the superior vena cava or the inferior vena cava. Catheter tip confirmation is usually achieved by plain radiography. We describe a case of a 9-month-old boy with complex congenital heart disease (heterotaxy syndrome, polysplenia type) who underwent pulmonary artery banding to reduce pulmonary blood flow to control heart failure symptoms. PICC was placed in the left femoral vein during the postoperative period. PICC tip confirmation was obtained by anteroposterior plain abdominal radiograph (figure 1), which demonstrated catheter tip bending at T12. The lateral radiograph of the abdomen showed that the PICC courses posteriorly into the lumbar venous plexus (figure 2). The ascending lumbar veins arises at L5–S1 from the common iliac vein and drains into...
Revision spine surgery is extremely challenging in super-super obese patients (body mass index (BMI) ≥60 kg/m2). This is the first report describing how bariatric surgery was useful for a super-super obese patient with progressing myelopathy. A 44-year-old man with a BMI of 62.9 kg/m2 presented with an ambulatory disorder caused by thoracic ossification of the posterior longitudinal ligament (T7–8). Before this paraparesis, he had undergone four spinal operations, and was not considered a good candidate for a fifth spine surgery. At the time of the fourth operation, he had reached a maximum weight of 205 kg (BMI 69.3 kg/m2). Instead, he underwent a laparoscopic sleeve gastrectomy. Sixteen months later, his body weight had decreased to BMI 35.2 kg/m2, and he could walk without a walker. In addition to reducing our patient's load, a 'non-operative' form of dekyphosis due to altered thoracic spinal alignment secondary to weight loss may explain the improvement in his myelopathy.
Description
A 69-year-old woman on apixaban for 4 years due to her atrial fibrillation presented with severe left lower abdominal pain. She was discharged from the hospital 4 days prior after treatment for influenza and had finished a course of oseltamivir. She did not receive any heparin products and was continued on apixaban during that admission. A few hours before presentation, she reported coughing severely with sudden onset of excruciating abdominal pain. She denied trauma or injury to the abdomen. On exam, she was alert, normotensive and tachycardic, with significant left lower quadrant tenderness in the abdomen. Laboratory results were significant for decreased haemoglobin from 15.2 to 12.9 g/dL. CT of the abdomen showed acute left inferior rectus abdominis muscle haematoma (7.5 cm), along with stable and unchanged left adnexal cystic lesion (figure 1). Apixaban was discontinued, and the patient was closely monitored in the hospital with supportive care....
A 79-year-old man was admitted electively for investigation of weight loss. While he was an inpatient, he developed severe epigastric pain and an initial blood test revealed an acutely raised amylase (>2000) and deranged liver function tests. A contrast CT angiography showed a large haematoma adjacent to the duodenum, spreading in the retroperitoneal space, arising from a 2 cm bleeding pseudoaneurysm in the region of the gastroduodenal artery. Due to his underlying comorbidities, he was deemed unfit for surgical repair and he had coil embolisation with successful haemostasis. The gastroduodenal artery aneurysms are rare and constitute 1.5% of all visceral artery aneurysms. They can be an incidental finding or they can present with haemorrhagic shock, abdominal pain and rarely with obstructive jaundice or hyperamylasaemia. The diagnosis is usually made with an angiography. Variable treatment options are available depending on the patient's fitness and haemodynamic stability.
Description
A 45-year-old man with known history of coronary artery disease and bicuspid aortic valve (BAV) (figure 1) was admitted for worsening symptoms of angina. Coronary angiogram showed single coronary artery arising from the left cusp, trifurcating into right coronary artery, left anterior descending (LAD) and left circumflex artery (LCx) (figure 2). No course of the left main coronary artery between the aortic root and the pulmonary artery was noted. There was obstructive disease in proximal LAD (70%), first diagonal artery (80%) and proximal LCx (70%). Peak gradient of 51 mm Hg across the BAV was registered. He underwent bypass graft surgery along with an aortic valve replacement successfully.
Figure 1
Transoesophageal echocardiogram. Parasternal short axis view revealing bicuspid aortic valve (BAV). Red arrows pointing at aortic valve cusps.
Figure 2
(A) Left anterior oblique (LAO) caudal view....
Purpose. The purpose of this study is to verify whether the headless cannulated compression screw (HCCS) has higher biomechanical stability than the ordinary cannulated compression screw (OCCS) in the treatment of vertical femoral neck fractures. Materials and Methods. 30 synthetic femur models were equally divided into 2 groups, with 50°, 60°, and 70° Pauwels angle of femoral neck fracture, under 3D printed guiding plates and C-arm fluoroscopic guidance. The femur molds were fixed with three parallel OCCSs as OCCS group and three parallel HCCSs as HCCS group. All specimens were tested for compressive strength and maximum load to failure with a loading rate of 2 mm/min. Results. The result showed that there was no significant difference with the compressive strength in the Pauwels angle of 50° and 60°. However, we observed that the maximum load to failure with the Pauwels angle of 50°, 60°, and 70° and the compressive strength with 70° of HCCS group showed better performance than the OCCS group. Conclusion. HCCS performs with better biomechanical stability than OCCS in the treatment of vertical femoral neck fracture, especially with the Pauwels angle of 70°.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2qo3VuF
via IFTTT
The diagnosis of oral lesions is sometimes difficult due to both the clinician's limited experience with the conditions that may cause the lesions and their similar appearances, especially in children. Correctly establishing a definitive diagnosis is of major importance to clinicians who manage patients with oral mucosal diseases. In patients with Fanconi anaemia (FA), oral ulcers occur frequently, which are quite variable, and may lead to a misdiagnosis or failure to diagnose. Here, we report the case of a 15-year-old boy who was examined for squamous cell cancer of the tongue and diagnosed as having FA without any haematological manifestations. While surgery could not be done, both radiotherapy and chemotherapy had to be decreased. He died of progressive disease 6 months after the diagnosis. Unexplained ulcers in a child with a duration longer than 2 weeks should be further evaluated, especially for FA, even without the presence of anaemia.
https://ift.tt/2HitxCZ
The old approach of one therapeutic for all patients with mCRC is evolving with a need to target specific molecular aberrations or cell-signalling pathways. Molecular screening approaches and new biomarkers are required to fully characterize tumours, identify patients most likely to benefit, and predict treatment response.
MODUL is a signal-seeking trial with a design that is highly adaptable, permitting modification of different treatment cohorts and inclusion of further additional cohorts based on novel evidence on new compounds/combinations that emerge during the study.
MODUL is ongoing and its adaptable nature permits timely and efficient recruitment of patients into the most appropriate cohort. Recruitment will take place over approximately 5 years in Europe, Asia, Africa, and South America. The design of MODUL with ongoing parallel/sequential treatment cohorts means that the overall size and duration of the trial can be modified/prolonged based on accumulation of new data.
The early success of the current trial suggests that the design may provide definitive leads in a patient-friendly and relatively economical trial structure. Along with other biomarker-driven trials that are currently underway, it is hoped that MODUL will contribute to the continuing evolution of clinical trial design and permit a more 'tailored' approach to the treatment of patients with mCRC.
The diagnosis of oral lesions is sometimes difficult due to both the clinician's limited experience with the conditions that may cause the lesions and their similar appearances, especially in children. Correctly establishing a definitive diagnosis is of major importance to clinicians who manage patients with oral mucosal diseases. In patients with Fanconi anaemia (FA), oral ulcers occur frequently, which are quite variable, and may lead to a misdiagnosis or failure to diagnose. Here, we report the case of a 15-year-old boy who was examined for squamous cell cancer of the tongue and diagnosed as having FA without any haematological manifestations. While surgery could not be done, both radiotherapy and chemotherapy had to be decreased. He died of progressive disease 6 months after the diagnosis. Unexplained ulcers in a child with a duration longer than 2 weeks should be further evaluated, especially for FA, even without the presence of anaemia.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HitxCZ
via IFTTT
IJMS, Vol. 19, Pages 1164: A Novel Synthetic Material, BMM, Accelerates Wound Repair by Stimulating Re-Epithelialization and Fibroblast Activation
International Journal of Molecular Sciences doi: 10.3390/ijms19041164
Authors: Ga Seo Changlim Hyun Dongsoo Koh Sanggyu Park Yoongho Lim Young Kim Moonjae Cho
Cutaneous wound repair is an intricate process whereby the skin reprograms itself after injury. In the mid-phase of wound repair, the proliferation, migration, and differentiation of cells are the major mechanisms to lead remodeling. We investigated the effect of BMM ((1E,2E)-1,2-bis((6-bromo-2H-chromen-3-yl)methylene)hydrazine), a novel synthetic material, on the migration and viability of keratinocytes or fibroblasts using the in vitro scratch woundhealing, electric cell-substrate imedance sensing (ECIS), invasion, and MTT assays. Cell migration-related factors were analyzed using western blot, and we found that treatment with BMM stimulated the EMT pathway and focal adhesion kinase (FAK)/Src signaling. Differentiation of HaCaT keratinocyte and fibroblast cells was also stimulated by BMM and specifically, NOX2/4 contributed to the activation of fibroblasts for wound healing. Furthermore, BMM treated HaCaT keratinocyte and fibroblast-co-cultured cells increased migration and differentiation. TGF-β and Cyr61 were also secreted to a greater extent than in single cultured cells. In vivo experiments showed that treatment with BMM promotes wound closure by promoting re-epithelialization. In this study, we demonstrated that a novel synthetic material, BMM, is capable of promoting wound healing via the stimulation of re-epithelialization in the epidermis and the activation of fibroblasts in the dermis, in particular, via the acceleration of the interaction between the epidermis and dermis.
Salvia miltiorrhiza Bunge (Danshen), a common medicinal plant in traditional Chinese medicine, has been tested effectively to prevent urolithiasis in animals; nevertheless, the clinical application for urolithiasis remains unclear. We thus investigated the clinical effect of Danshen by analyzing the database from the Taiwan National Institute of Health. The cohort "Danshen-users" was prescribed Chinese herb medicine Danshen after the initial diagnosis of calculus. The control group (non-Danshen-users) was not given Danshen after the initial diagnosis of calculus. The date of first using Danshen after new diagnosis date of calculus was considered as index date. The outcome variables were categorized into two categories: the first category included calculus surgical treatment, including extracorporeal shock wave lithotripsy, ureteroscopy, percutaneous nephrostomy with fragmentation, and ureterolithotomy; the second category included any bleeding disorders, including gastrointestinal bleeding, intracranial hemorrhage, and blood transfusions. The incidence of calculus surgical treatment in the Danshen-users was less than that in the non-Danshen-users: 1.071% in 1,000 person-years (200 people followed up for 5 years) and 3.142% in 1,000 person-years, respectively. The adjusted hazard ratio for calculus surgical treatment in the Danshen-users was 0.34 (95% confidence intervals: 0.31–0.38) as compared to the non-Danshen-users. When stratified by sex, the incidence of calculus surgical treatment in Danshen-users was 0.685% in 1,000 person-years and 1.575% in 1,000 person-years for women and men, respectively, which was lower than that in non-Danshen-users. Danshen decreased the ratio of subsequent stone treatment after the first treatment in the study population; there was no increased bleeding risk due to long-term Danshen use.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GTgHf2
via IFTTT
Despite great advances in understanding of molecular pathogenesis and achievement of a high cure rate in medulloblastoma, recurrent medulloblastomas are still dismal. Additionally, misidentification of secondary malignancies due to histological ambiguity leads to misdiagnosis and eventually to inappropriate treatment. Nevertheless, the genomic characteristics of recurrent medulloblastomas are poorly understood, largely due to a lack of matched primary and recurrent tumor tissues. We performed a genomic analysis of recurrent tumors from 17 pediatric medulloblastoma patients. Whole transcriptome sequencing revealed that a subset of recurrent tumors initially diagnosed as locally recurrent medulloblastomas are secondary glioblastomas after radiotherapy, showing high similarity to the non-G-CIMP proneural subtype of glioblastoma. Further analysis, including whole exome sequencing, revealed missense mutations or complex gene fusion events in PDGFRA with augmented expression in the secondary glioblastomas after radiotherapy, implicating PDGFRA as a putative driver in the development of secondary glioblastomas after treatment exposure. This result provides insight into the possible application of PDGFRA-targeted therapy in these second malignancies. Furthermore, genomic alterations of TP53 including 17p loss or germline/somatic mutations were also found in most of the secondary glioblastomas after radiotherapy, indicating a crucial role of TP53 alteration in the process. On the other hand, analysis of recurrent medulloblastomas revealed that the most prevalent alterations are the loss of 17p region including TP53 and gain of 7q region containing EZH2 which already exist in primary tumors. The 7q gain events are frequently accompanied by high expression levels of EZH2 in both primary and recurrent medulloblastomas, which provides a clue to a new therapeutic target to prevent recurrence. Considering the fact that it is often challenging to differentiate between recurrent medulloblastomas and secondary glioblastomas after radiotherapy, our findings have major clinical implications both for correct diagnosis and for potential therapeutic interventions in these devastating diseases.
Therapeutic use of leaves of M. oleifera has been evaluated in diabetes because of its possible capacity to decrease blood glucose and lipids concentration after ingestion, as result of the polyphenols content an...
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2v81MYK
via IFTTT
Lysimachia christinae Hance is a traditional Chinese medicine with diuretic, detumescent, and detoxifying effects. Our aimed to optimize the extraction protocol to maximize the yield of flavonoids from Lysimachia...
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HaP4gL
via IFTTT
Transplant renal artery stenosis (TRAS) is the most frequent vascular complication after kidney transplantation (KT) and has been associated with potentially reversible refractory hypertension, graft dysfunction, and reduced patient survival. The aim of the study is to describe the outcomes of a standardized Duplex Ultrasound- (DU-) based screening protocol for early diagnosis of TRAS and for selection of patients potentially requiring endovascular intervention. We retrospectively reviewed our prospectively collected database of KT from January 1998 to select patients diagnosed with TRAS. The follow-up protocol was based on a risk-adapted, dynamic subdivision of eligible KT patients in different risk categories (RC) with different protocol strategies (PS). Of 598 patients included in the study, 52 (9%) patients had hemodynamically significant TRAS and underwent percutaneous angioplasty (PTA) and stent placement. Technical and clinical success rates were 97% and 90%, respectively. 7 cases of restenosis were recorded at follow-up and treated with re-PTA plus stenting. Both DU imaging and clinical parameters improved after stent placement. Prospective high-quality studies are needed to test the efficacy and safety of our protocol in larger series. Accurate trial design and standardized reporting of patient outcomes will be key to address the current clinical needs.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JDbntY
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 179-181, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JxQz73
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 156-158, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDEs4z
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 152-155, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JzpUqe
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 159-161, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2ED1Jno
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 186-189, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JCHwlh
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 162-164, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2ECGBxx
via IFTTT
Publication date: September 2018
Source:Journal of Environmental Radioactivity, Volume 189
Author(s): Guembou Shouop Cebastien Joel, Ndontchueng Moyo Maurice, Nguelem Mekongtso Eric Jilbert, Motapon Ousmanou, Strivay David
The combination of gamma-ray spectrometry, the development of related Monte Carlo method and the GEANT4 (GEometry ANd Tracking) toolkit have been developed for gamma spectrometry simulation. The main objective was to validate simulation models of broad energy germanium (BEGe) detector geometry built in our laboratory (BE6530 model). Monte Carlo simulation of the geometry of BE6530 detector for efficiency calibration was carried out with GEANT4 toolkit. The simulated efficiencies curves using MC were compared with experimental results. Measurement uncertainties for both simulation and experimental estimations of the efficiency were assessed in order to see whether the consequences of the realistic measurement fall inside adequate cut-off points. The validation of the simulation was carried out by experimentally estimating the activity concentration in a reference sample and the comparison showed good correlation between experimental and simulation. Therefore, from the outcomes of this study, it can be concluded that Monte-Carlo simulation is a helpful, reasonable option that additionally gives more prominent adaptability, greater flexibility, precision and accuracy, and gained time when determining the detector response and efficiency in routine of environmental radioactivity monitoring.
Clinical Thyroidology, Volume 30, Issue 4, Page 165-170, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDdh9S
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 159-161, April 2018.
https://ift.tt/2ED1Jno
Clinical Thyroidology, Volume 30, Issue 4, Page 175-178, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JCHvOf
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 179-181, April 2018.
https://ift.tt/2JxQz73
Clinical Thyroidology, Volume 30, Issue 4, Page 156-158, April 2018.
https://ift.tt/2EDEs4z
Clinical Thyroidology, Volume 30, Issue 4, Page 182-185, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JEwXht
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 152-155, April 2018.
https://ift.tt/2JzpUqe
Clinical Thyroidology, Volume 30, Issue 4, Page 171-174, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDwkRz
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 190-192, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JDEZaj
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 186-189, April 2018.
https://ift.tt/2JCHwlh
Journal of Interferon &Cytokine Research, Volume 38, Issue 4, Page 171-185, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GOxsI9
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 175-178, April 2018.
https://ift.tt/2JCHvOf
Journal of Interferon &Cytokine Research, Volume 38, Issue 4, Page 153-160, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2qlaQns
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 165-170, April 2018.
https://ift.tt/2EDdh9S
Journal of Interferon &Cytokine Research, Volume 38, Issue 4, Page 161-170, April 2018.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GN61hI
via IFTTT
Clinical Thyroidology, Volume 30, Issue 4, Page 182-185, April 2018.
https://ift.tt/2JEwXht
Clinical Thyroidology, Volume 30, Issue 4, Page 171-174, April 2018.
https://ift.tt/2EDwkRz
Clinical Thyroidology, Volume 30, Issue 4, Page 190-192, April 2018.
https://ift.tt/2JDEZaj
De Blasi, B; Barnes, A; Boscolo Galazzo, I; Hua, C-H; Shulkin, B; Koepp, M; Tisdall, M; (2018) Age-Specific 18F-FDG Image Processing Pipelines and Analysis Are Essential for Individual Mapping of Seizure Foci in Paediatric Patients with Intractable Epilepsy. Journal of Nuclear Medicine 10.2967/jnumed.117.203950 . Green open access
https://ift.tt/2Hsnut1
Jehiel, P; Lamy, L; (2018) A Mechanism Design Approach to the Tiebout Hypothesis. Journal of Political Economy , 126 (2) pp. 735-760. 10.1086/696273 .
https://ift.tt/2EDdZEc
Cheang, MH; Barber, NJ; Khushnood, A; Hauser, JA; Kowalik, GT; Steeden, JA; Quail, MA; ... Muthurangu, V; + view all Cheang, MH; Barber, NJ; Khushnood, A; Hauser, JA; Kowalik, GT; Steeden, JA; Quail, MA; Tullus, K; Hothi, D; Muthurangu, V; - view fewer (2018) A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance , 20 (1) , Article 24. 10.1186/s12968-018-0444-0 . Green open access
https://ift.tt/2HwZpkZ
Graziani, F; D'Aiuto, F; Gennai, S; Petrini, M; Nisi, M; Cirigliano, N; Landini, L; ... Ghiadoni, L; + view all Graziani, F; D'Aiuto, F; Gennai, S; Petrini, M; Nisi, M; Cirigliano, N; Landini, L; Bruno, RM; Taddei, S; Ghiadoni, L; - view fewer (2017) Systemic Inflammation after Third Molar Removal: A Case-Control Study. Journal of Dental Research , 96 (13) pp. 1505-1512. 10.1177/0022034517722775 . Green open access
https://ift.tt/2EDdA4E
Anagnostou, G; Boem, F; Kuenzel, S; Pal, BC; Parisini, T; (2017) Observer-based Anomaly Detection of Synchronous Generators for Power Systems Monitoring. IEEE Transactions on Power Systems 10.1109/TPWRS.2017.2771278 . (In press). Green open access
https://ift.tt/2HrT761
Mazumder, S; Upadhyay, RP; Hill, Z; Taneja, S; Dube, B; Kaur, J; Shekhar, M; ... Bhandari, N; + view all Mazumder, S; Upadhyay, RP; Hill, Z; Taneja, S; Dube, B; Kaur, J; Shekhar, M; Ghosh, R; Bisht, S; Martines, JC; Bahl, R; Sommerfelt, H; Bhandari, N; - view fewer (2018) Kangaroo mother care: using formative research to design an acceptable community intervention. BMC Public Health , 18 , Article 307. 10.1186/s12889-018-5197-z . Green open access
https://ift.tt/2EDoRC2
Zheng, H; Shan, Y; Mi, Z; Meng, J; Ou, J; Schroeder, H; Guan, D; (2018) How modifications of China's energy data affect carbon mitigation targets. Energy Policy , 116 pp. 337-343. 10.1016/j.enpol.2018.02.031 .
https://ift.tt/2HwiBze
Fina, F; Madla, CM; Goyanes, A; Zhang, J; Gaisford, S; Basit, AW; (2018) Fabricating 3D printed orally disintegrating printlets using selective laser sintering. International Journal of Pharmaceutics , 541 (1-2) pp. 101-107. 10.1016/j.ijpharm.2018.02.015 .
https://ift.tt/2ECOXoM
Northam, GB; Adler, S; Eschmann, KCJ; Chong, WK; Cowan, FM; Baldeweg, T; (2018) Developmental conduction aphasia after neonatal stroke. Annals of Neurology 10.1002/ana.25218 . (In press).
https://ift.tt/2HtQsbV
Wang, K; Mi, Z; Wei, YM; (2018) Will Pollution Taxes Improve Joint Ecological and Economic Efficiency of Thermal Power Industry in China?: A DEA-Based Materials Balance Approach. Journal of Industrial Ecology 10.1111/jiec.12740 . (In press).
https://ift.tt/2EDBzkb
Boem, F; Gallo, AJ; Ferrari-Trecate, G; Parisini, T; (2017) A Distributed Attack Detection Method for Multi-Agent Systems Governed by Consensus-Based Control. In: (Proceedings) IEEE 56th Annual Conference on Decision and Control (CDC). IEEE (In press). Green open access
https://ift.tt/2HrALCb
Tsuchiya, Y; Zhyvoloup, A; Bakovic, J; Thomas, N; Yi Kun Yu, B; Das, S; Orengo, C; ... Gout, I; + view all Tsuchiya, Y; Zhyvoloup, A; Bakovic, J; Thomas, N; Yi Kun Yu, B; Das, S; Orengo, C; Newell, C; Ward, J; Saladino, G; Comitani, F; Gervasio, FL; Malanchuk, OM; Khoruzhenko, AI; Filonenko, V; Peak-Chew, SY; Skehel, M; Gout, I; - view fewer (2018) Protein CoAlation and antioxidant function of Coenzyme A in prokaryotic cells. Biochemical Journal 10.1042/BCJ20180043 . (In press).
https://ift.tt/2EDa3nb
Gallo, A; Turan, MS; Nahata, P; Boem, F; Ferrari-Trecate, G; Parisini, T; (2018) Distributed Cyber-Attack Detection in the Secondary Control of DC Microgrids. In: (Proceedings) European Control Conference. (In press). Green open access
https://ift.tt/2Hsey6S
Jeffery, KJ; (2018) The Hippocampus: From Memory, to Map, to Memory Map. [Editorial comment]. Trends in Neurosciences , 41 (2) pp. 64-66. 10.1016/j.tins.2017.12.004 .
https://ift.tt/2GSnnWy
Rezlescu, C; Susilo, T; Wilmer, JB; Caramazza, A; (2017) The inversion, part-whole, and composite effects reflect distinct perceptual mechanisms with varied relationships to face recognition. Journal of Experimental Psychology: Human Perception and Performance , 43 (12) pp. 1961-1973. 10.1037/xhp0000400 . Green open access
https://ift.tt/2HqGlVa
Curran, HV; Nutt, D; de Wit, H; (2018) Psychedelics and related drugs: therapeutic possibilities, mechanisms and regulation. [Editorial comment]. Psychopharmacology , 235 (2) pp. 373-375. 10.1007/s00213-017-4822-3 .
https://ift.tt/2ED0vbM
Bageghni, SA; Hemmings, KE; Zava, N; Denton, CP; Porter, KE; Ainscough, JFX; Drinkhill, MJ; Bageghni, SA; Hemmings, KE; Zava, N; Denton, CP; Porter, KE; Ainscough, JFX; Drinkhill, MJ; Turner, NA; - view fewer (2018) Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism. FASEB Journal 10.1096/fj.201701455RR . (In press). Green open access
https://ift.tt/2Hs3CWQ
Casswell, EJ; Abou Ltaif, S; Carr, T; Keane, PA; Charteris, DG; Wickham, L; (2018) Widefield Spectral-Domain Optical Coherence Tomography Imaging of Peripheral Round Retinal Holes With or Without Retinal Detachment. Retina 10.1097/IAE.0000000000002133 . (In press).
https://ift.tt/2EDzTak
Chandrasekaran, D; Manchanda, R; (2018) Germline & somatic genetic testing in ovarian cancer patients. BJOG 10.1111/1471-0528.15225 . (In press).
https://ift.tt/2HsWauN
Sahni, JN; Czanner, G; Gutu, T; Taylor, SA; Bennett, KM; Wuerger, SM; Grierson, I; ... Harding, SP; + view all Sahni, JN; Czanner, G; Gutu, T; Taylor, SA; Bennett, KM; Wuerger, SM; Grierson, I; Murray-Dunning, C; Holland, MN; Harding, SP; - view fewer (2017) Safety and acceptability of an organic light-emitting diode sleep mask as a potential therapy for retinal disease. Eye , 31 pp. 97-106. 10.1038/eye.2016.259 . Green open access
https://ift.tt/2GSQ4mf
De Blasi, B; Barnes, A; Boscolo Galazzo, I; Hua, C-H; Shulkin, B; Koepp, M; Tisdall, M; (2018) Age-Specific 18F-FDG Image Processing Pipelines and Analysis Are Essential for Individual Mapping of Seizure Foci in Paediatric Patients with Intractable Epilepsy. Journal of Nuclear Medicine 10.2967/jnumed.117.203950 . Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2Hsnut1
via IFTTT
Jehiel, P; Lamy, L; (2018) A Mechanism Design Approach to the Tiebout Hypothesis. Journal of Political Economy , 126 (2) pp. 735-760. 10.1086/696273 .
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDdZEc
via IFTTT
Graziani, F; D'Aiuto, F; Gennai, S; Petrini, M; Nisi, M; Cirigliano, N; Landini, L; ... Ghiadoni, L; + view all Graziani, F; D'Aiuto, F; Gennai, S; Petrini, M; Nisi, M; Cirigliano, N; Landini, L; Bruno, RM; Taddei, S; Ghiadoni, L; - view fewer (2017) Systemic Inflammation after Third Molar Removal: A Case-Control Study. Journal of Dental Research , 96 (13) pp. 1505-1512. 10.1177/0022034517722775 . Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDdA4E
via IFTTT
Anagnostou, G; Boem, F; Kuenzel, S; Pal, BC; Parisini, T; (2017) Observer-based Anomaly Detection of Synchronous Generators for Power Systems Monitoring. IEEE Transactions on Power Systems 10.1109/TPWRS.2017.2771278 . (In press). Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HrT761
via IFTTT
Zheng, H; Shan, Y; Mi, Z; Meng, J; Ou, J; Schroeder, H; Guan, D; (2018) How modifications of China's energy data affect carbon mitigation targets. Energy Policy , 116 pp. 337-343. 10.1016/j.enpol.2018.02.031 .
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HwiBze
via IFTTT
Fina, F; Madla, CM; Goyanes, A; Zhang, J; Gaisford, S; Basit, AW; (2018) Fabricating 3D printed orally disintegrating printlets using selective laser sintering. International Journal of Pharmaceutics , 541 (1-2) pp. 101-107. 10.1016/j.ijpharm.2018.02.015 .
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2ECOXoM
via IFTTT
Northam, GB; Adler, S; Eschmann, KCJ; Chong, WK; Cowan, FM; Baldeweg, T; (2018) Developmental conduction aphasia after neonatal stroke. Annals of Neurology 10.1002/ana.25218 . (In press).
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HtQsbV
via IFTTT
Wang, K; Mi, Z; Wei, YM; (2018) Will Pollution Taxes Improve Joint Ecological and Economic Efficiency of Thermal Power Industry in China?: A DEA-Based Materials Balance Approach. Journal of Industrial Ecology 10.1111/jiec.12740 . (In press).
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDBzkb
via IFTTT
Boem, F; Gallo, AJ; Ferrari-Trecate, G; Parisini, T; (2017) A Distributed Attack Detection Method for Multi-Agent Systems Governed by Consensus-Based Control. In: (Proceedings) IEEE 56th Annual Conference on Decision and Control (CDC). IEEE (In press). Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HrALCb
via IFTTT
Gallo, A; Turan, MS; Nahata, P; Boem, F; Ferrari-Trecate, G; Parisini, T; (2018) Distributed Cyber-Attack Detection in the Secondary Control of DC Microgrids. In: (Proceedings) European Control Conference. (In press). Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2Hsey6S
via IFTTT
Jeffery, KJ; (2018) The Hippocampus: From Memory, to Map, to Memory Map. [Editorial comment]. Trends in Neurosciences , 41 (2) pp. 64-66. 10.1016/j.tins.2017.12.004 .
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GSnnWy
via IFTTT
Rezlescu, C; Susilo, T; Wilmer, JB; Caramazza, A; (2017) The inversion, part-whole, and composite effects reflect distinct perceptual mechanisms with varied relationships to face recognition. Journal of Experimental Psychology: Human Perception and Performance , 43 (12) pp. 1961-1973. 10.1037/xhp0000400 . Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HqGlVa
via IFTTT
Bageghni, SA; Hemmings, KE; Zava, N; Denton, CP; Porter, KE; Ainscough, JFX; Drinkhill, MJ; Bageghni, SA; Hemmings, KE; Zava, N; Denton, CP; Porter, KE; Ainscough, JFX; Drinkhill, MJ; Turner, NA; - view fewer (2018) Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism. FASEB Journal 10.1096/fj.201701455RR . (In press). Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2Hs3CWQ
via IFTTT
Casswell, EJ; Abou Ltaif, S; Carr, T; Keane, PA; Charteris, DG; Wickham, L; (2018) Widefield Spectral-Domain Optical Coherence Tomography Imaging of Peripheral Round Retinal Holes With or Without Retinal Detachment. Retina 10.1097/IAE.0000000000002133 . (In press).
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2EDzTak
via IFTTT
Chandrasekaran, D; Manchanda, R; (2018) Germline & somatic genetic testing in ovarian cancer patients. BJOG 10.1111/1471-0528.15225 . (In press).
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HsWauN
via IFTTT
Sahni, JN; Czanner, G; Gutu, T; Taylor, SA; Bennett, KM; Wuerger, SM; Grierson, I; ... Harding, SP; + view all Sahni, JN; Czanner, G; Gutu, T; Taylor, SA; Bennett, KM; Wuerger, SM; Grierson, I; Murray-Dunning, C; Holland, MN; Harding, SP; - view fewer (2017) Safety and acceptability of an organic light-emitting diode sleep mask as a potential therapy for retinal disease. Eye , 31 pp. 97-106. 10.1038/eye.2016.259 . Green open access
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GSQ4mf
via IFTTT
Evolutionary allometry describes size and shape differences across taxa matched for developmental stage (e.g., adulthood). Allometric studies can identify subtle differences among species, and therefore help researchers interested in small-bodied, cryptic species such as tarsiers. Recent taxonomic revision has emphasized size differences among three possible tarsier genera inhabiting different island regions: Sulawesi (genus: Tarsius), Borneo (genus: Cephalopachus), and the Philippines (genus: Carlito). We examined seven craniodental measures of 102 museum specimens of adult tarsiers representing these three regions. We found that the allometric patterns within groups do not predict the observable differences among groups. Crania of the largest-bodied genus, Cephalopachus, are characterized by relatively short skulls and small orbits, with wider palates and molars than predicted by allometric increase from the smaller-bodied Tarsius. Overall, we found tarsier skulls stay the same shape as they increase in size. This may reflect shared developmental and biomechanical adaptations across tarsier groups filling an extreme leaping, faunivorous niche with hypertrophied orbits and subtle dietary differences in prey selection. These shared adaptations of tarsiers may severely limit the range of body sizes in tarsiers and impose further constraints on cranial shape. Despite their deep divergence times in the Miocene, living tarsier groups are united by a common craniodental form across a limited size range. Adaptations to extreme niches might result in a hyperconservatism of the cranium. Future primate allometric studies should explore cranial variation in other taxa to determine how adaptations to specific niches affect the size and shape of the cranium.
Publication date: Available online 11 April 2018
Source:American Journal of Infection Control
Author(s): Eric Vozzola, Michael Overcash, Evan Griffing
BackgroundIsolation gowns serve a critical role in infection control by protecting healthcare workers, visitors, and patients from the transfer of microorganisms and body fluids. The decision of whether to use a reusable or disposable garment system is a selection process based on factors including sustainability, barrier effectiveness, cost, and comfort. Environmental sustainability is increasingly being used in the decision-making process. Life cycle assessment is the most comprehensive and widely used tool used to evaluate environmental performance.MethodsThe environmental impacts of market-representative reusable and disposable isolation gown systems were compared using standard life cycle assessment procedures. The basis of comparison was 1,000 isolation gown uses in a healthcare setting. The scope included the manufacture, use, and end-of-life stages of the gown systems.ResultsAt the healthcare facility, compared to the disposable gown system, the reusable gown system showed a 28% reduction in energy consumption, a 30% reduction in greenhouse gas emissions, a 41% reduction in blue water consumption, and a 93% reduction in solid waste generation.ConclusionsSelecting reusable garment systems may result in significant environmental benefits compared to selecting disposable garment systems. By selecting reusable isolation gowns, healthcare facilities can add these quantitative benefits directly to their sustainability scorecards.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2GSKuQT
via IFTTT
Primary follicular lymphoma of the duodenum (FL-D) constitutes a rare subtype of extranodal follicular lymphoma with a usually indolent course. To date, no distinct treatment recommendations have been defined for those patients. We report the case of a 58-year-old male patient presenting with endoscopically assessed, symptomatic FL-D who was treated with clarithromycin monotherapy in analogy to recent data for mucosa-associated lymphoid tissue lymphoma. Each treatment cycle consisted of clarithromycin 500 mg twice daily for 3 weeks followed by a 2-week break. After four cycles of treatment, the patient showed a very good response with normal macroscopic findings confirmed by endosonographic examination and only focal minimal residual disease of lymphoma persisting in the histological assessment. The patient is currently asymptomatic and without treatment for 24+ months. As clarithromycin combines antimicrobial and direct antiproliferative effects mediated through a variety of pleiotropic mechanisms, this appears to be an interesting treatment approach for indolent lymphoma, particularly in those where a chronic infectious background cannot be completely ruled out, i.e., gastrointestinal manifestations. We suggest further investigation of this treatment approach.
Case Rep Oncol 2018;11:239–245
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2qpUPN9
via IFTTT
Authors: Hélène Yera, Émilie Fréalle, Emmanuel Dutoit and Jean Dupouy-Camet.<br />Parasite Vol. 25 , page 23<br /> Keywords: Anisakidosis ; Anisakiasis ; human ; Anisakis ; incidence ; allergy ; fish.<img src="https://ift.tt/2GT5C9J" height="1" width="1" alt=""/>
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2HtJfbU
via IFTTT
This case report describes a 38-year-old female presenting with a thigh abscess caused by Eikenella corrodens, Actinomyces sp., and α-hemolytic Streptococcus following an intramuscular vitamin B12 injection administered at an outpatient clinic. After failure to improve clinically with intravenous daptomycin and after visualization of the abscess with gas bubbles on CT scan, she was taken to the operating room for three separate surgical irrigation and debridement procedures. Treatment also included intravenous ampicillin/sulbactam followed by oral amoxicillin/clavulanic acid therapy. She remained symptom free and without infection at nine months following hospitalization. It was suspected that poor hygiene played a role in the infection, but a definitive cause was not identified.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2vaZiIW
via IFTTT
Kluyvera spp. can cause various infections. However, carbapenemase-producing Kluyvera spp. has not been previously reported. We report a case of biliary tract infection caused by KPC-2-producing K. ascorbata in a 13-year-old female. To the best of our knowledge, this is the first report on infection caused by carbapenemase-producing Kluyvera spp.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2He4K2S
via IFTTT
Publication date: 12 June 2018
Source:Journal of Ethnopharmacology, Volume 219
Author(s): Lucas Olivo Martins Pereira, Wagner Vilegas, Marcelo Marucci Pereira Tangerina, Karuppusamy Arunachalam, Sikiru Olaitan Balogun, Paulo Eduardo Orlandi-Mattos, Edson Moleta Colodel, Domingos Tabajara de Oliveira Martins
Ethnopharmacological importanceLafoensia pacari A. St.-Hil., (Lythraceae) is a native tree of Brazilian Cerrado and commonly known in Brazil as "mangava-brava". Its leaves are used in Brazilian folk medicine in wound healing, cutaneous mycoses, and in the treatment of gastritis and ulcers.Aim of the studyThe present study was designed to evaluate the wound healing activity and mechanism of action of the hydroethanolic extract of Lafoensia pacari A. St.-Hil. leaves (HELp), and to advance in its chemical profiling.Materials and methodsHELp was prepared by maceration in 70% hydroethanolic solution (1:10, w/v). The phytochemical analyses were investigated using colorimetry and electrospray ionization/mass spectrometric detection (ESI-MSn). Its in vitro cytotoxicity was evaluated in CHO-K1 and L929 cells, while the in vivo acute toxicity was performed in mice. The potential in vivo wound healing activity was assessed using excision and incision rat models and histopathology of the wounded skin (excision model) was carried out. The in vitro wound healing activity of HELp was demonstrated by scratch assay in L-929 cells, by measuring proliferation/migration rate and p-ERK 1/2 protein expression using western blot analysis. HELp's in vivo anti-inflammatory activity was evaluated by lipopolysaccharide (LPS) induced peritonitis in mice, along with the determination of nitric oxide (NO) and cytokines (TNF-α and IL-10) in the peritoneal lavages. Its potential in vitro antibacterial activity was performed using microbroth dilution assay, while in vitro antioxidant activities was by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and ferric reducing antioxidant power (FRAP) assays.ResultsThe phytochemical analysis of HELp revealed the presence of polyphenols with ellagic acid, punicalagin, punicalin, kaempferol, quercetin-3-O-xylopyranoside and quercetin-3-O-rhamnopyranoside being the most prominent. HELp showed no toxicity on CHO-k1 and L929 cell lines. Topical treatment with HELp (10 and 30 mg/g of gel) presented increased rates of wound contraction at all the days evaluated with complete wound re-epithelialization at 22.0 ± 1.5 (p < 0.05) and 21.7 ± 1.6 (p < 0.01) days, respectively. Topical application of HELp (10, 30 or 100 mg/g of gel) in incised wounds caused an increase in tensile break strength at all concentrations resulting in moderate re-epithelialization and neovascularization, increased cell proliferation an accelerated remodeling phase of the wound, in a manner comparable to standard drug (Madecassol®, 10 mg/g). In the scratch assay with L929 cells, HELp (0.1 and 0.03 mg/mL) and PDGF (5 ng/mL) resulted in the increased proliferation/migration rate of fibroblasts and higher expression of p-ERK 1/2 protein. In LPS-induced peritonitis, HELp (100 and 200 mg/kg p.o.) decreased total leukocyte migration, comparable to the dexamethasone (0.5 mg/kg p.o.). In RAW 264.7 macrophages activated by LPS, HELp produced anti-inflammatory activity dependent on increased concentrations of IL-10, reduction in NO production, without altering the TNF-α levels. HELp also presented potent antioxidant activity in the DPPH and FRAP, but lacks in vitro antibacterial activity.ConclusionThe present study results support the popular use of the leaves of L. pacari in the treatment of wounds. Its wound healing activity is multi-targeted and involves inhibition of the proliferative and anti-inflammatory phases, antioxidant and positive modulation of the remodeling phase that might be involved different secondary metabolites, with emphasis on the ellagic acid, punicalagin, punicalin, kaempferol, quercetin-3-O-xylopyranoside and quercetin-3-O-rhamnopyranoside.
Publication date: 28 June 2018
Source:Journal of Ethnopharmacology, Volume 220
Author(s): Glauco Jonas Lemos Santos, Emanuele Silva Oliveira, Ana Débora Nunes Pinheiro, Patricia Marçal da Costa, José Claudio Carneiro de Freitas, Francisco Glauco de Araújo Santos, Fernanda Maria Machado Maia, Selene Maia de Morais, Diana Célia Sousa Nunes-Pinheiro
Ethnopharmacological relevanceIn Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180).Materials and methodsHdCL was obtained in Crato-CE, Brazil. Qualitative phytochemicals assays, nuclear magnetic resonance (NMR) and microbiological analyzes were performed. Swiss mice were divided into six groups, according to tumor forms: 1) ascitic model, GI (Control; 0.9% saline), GII (S180asc) and GIII (S180asc/HdCL/14 days); 2) solid model, GIV (Control; 0.9% saline), GV (S180sol) and GVI (S180sol/HdCL/10 days). HdCL and 0.9% saline were administered at 0.2 mL, SID, by gavage, for 10 or 14 days. For ascitic model, 0.5 mL of S180 suspension (4×106 cells/mL) was inoculated intraperitoneally and for solid model, cells were inoculated subcutaneously (25 µL) on the right hind paw of mice. Blood samples were collected for hematological and oxidative stress evaluation. Thickness, volume and weight of paws were measured in solid model. After euthanasia, spleen, liver and kidney were collected in order to assess the relative organ weight. Tissue fragments of paws and popliteal lymph nodes (PLN) were analyzed by H&E and CD4+, CD8+, HSP-60+ and Foxp3+ immunohistochemistry.ResultsHdCL presented milky aspect and pinkish supernatant. Phenols, flavonols, flavanones, free steroids and cinnamoyl derivatives of lupeol, α-amyrin and β-amyrin were detected at the phytochemistry analysis. HdCL did not alter the relative weight of organs, hematological parameters and volume of ascitic fluid recovered. In solid model, HdCL reduced (P < 0.05) paw volume, but did not altered thickness, paw weight and histological parameters. S180sol induced necrosis, metastasis and destruction of bone, cartilage and muscles. Bleeding, vessel congestion and oncocytes were observed in PLN. In paw, HdCL did not alter FoxP3+ and HSP-60+ expressions but reduced the CD4+ and CD8+ expressions, while at PLN, HdCL reduced the expressions of all markers. HdCL decreased (P < 0.05) serum levels of malondialdehyde in ascitic model.ConclusionsTreatment with HdCL reduced oxidative damage and modulated the expressions of CD4+, CD8+, FoxP3+and HSP-60+ in S180 solid tumor model, which can be associated to the presence of triterpenes, such as α-amyrin, β-amyrin and lupeol cinnamate. Present data emphasizes the importance of immune system in cancer and highlights the evaluation of the pharmacological properties of plants used by population as phytoterapics.
The use of probiotics to improve anti-microbial defence, such as for influenza infections, is increasingly recommended. However, no data are available on the effect of probiotics on flu-associated secondary ba...
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader https://ift.tt/2JENpOW
via IFTTT
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and is driven by strong type 2 immune responses. Lactobacillus helveticus NS8 (NS8), a probiotic strain isolated from Mongolian koumiss, has anti-inflammatory activities. Here, we evaluated the therapeutic potential of NS8 on AD-like skin lesions by using SKH-1 hairless mice that underwent three cycles of epicutaneous sensitization (EC) with ovalbumin (OVA). NS8 (5 × 108 CFU/day) was orally administered to mice from 2 weeks before the first sensitization until the end of the study. NS8 attenuated the symptoms and pathological changes in the skin of AD mice. For example, NS8 reduced epidermal and dermal thickening and significantly restrained the infiltration of mast cells, eosinophils, and CD4+ T cells into the dermis. By analysing the Th1/Th2 cytokines produced in skin lesions, we found that NS8 significantly suppressed the expression of IL-4, IL-5, and IL-13 (P < 0.05), while it had no discernible effect on the expression of IFN-γ. Systemically, NS-8 reduced the total IgE and OVA-specific IgE levels in serum (P < 0.05). Our study demonstrates that oral administration of L. helveticus NS8 effectively alleviates AD severity in mice by suppressing the Th2 immune response. NS8 may be a promising candidate for prophylactic and therapeutic treatments of allergic diseases, such as AD.
