Violence and Gender, Ahead of Print.
https://ift.tt/2p5kAC3
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Πέμπτη 13 Σεπτεμβρίου 2018
Help-Seeking Behaviors and Intimate Partner Violence-Related Traumatic Brain Injury
Intensity-Modulated Radiation Therapy With or Without Concurrent Chemotherapy in Nonanaplastic Thyroid Cancer with Unresectable or Gross Residual Disease
Thyroid, Volume 28, Issue 9, Page 1180-1189, September 2018.
https://ift.tt/2Mwnnxi
Radioiodine Refractory Differentiated Thyroid Cancer: Time to Update the Classifications
Thyroid, Volume 28, Issue 9, Page 1083-1093, September 2018.
https://ift.tt/2Nakasx
Effect of Buparlisib, a Pan-Class I PI3K Inhibitor, in Refractory Follicular and Poorly Differentiated Thyroid Cancer
Thyroid, Volume 28, Issue 9, Page 1174-1179, September 2018.
https://ift.tt/2MwLrAa
Das Myxödemherz: The Myxedema Heart Herman Zondek 1887–1979
Thyroid, Volume 28, Issue 9, Page 1079-1080, September 2018.
https://ift.tt/2N82jm5
South Korean Thyroid Cancer Trends: Good News and Bad
Thyroid, Volume 28, Issue 9, Page 1081-1082, September 2018.
https://ift.tt/2Mw9KOO
Sonographically Estimated Risks of Malignancy for Thyroid Nodules Computed with Five Standard Classification Systems: Changes over Time and Their Relation to Malignancy
Thyroid, Volume 28, Issue 9, Page 1190-1197, September 2018.
https://ift.tt/2MrmWUZ
Novel variant of reversed midgut rotation – retro-arterial proximal jejunum and transverse colon: a case report and review of the literature
Reversed rotation of the midgut is the rarest variation of midgut malrotations, which are congenital disorders that result from aberrant rotation and fixation of the midgut during embryological development. Co...
https://ift.tt/2xaLBZo
Fifth Euro‐Asian Congress of Dermatovenereologists, Riga, Latvia
Dermatologic Therapy, EarlyView.
https://ift.tt/2x97V5s
First case of secukinumab successful therapy in a very elderly psoriatic patient
Dermatologic Therapy, EarlyView.
https://ift.tt/2CRYCfq
Inflammasome, interleukine 1, maladies auto-inflammatoires et dermatoses neutrophiliques
Publication date: Available online 13 September 2018
Source: Annales de Dermatologie et de Vénéréologie
Author(s): M.-S. Doutre
https://ift.tt/2CTucJN
Is Improved Insurance Coverage a Fleeting Opportunity?
The data from the Surveillance, Epidemiology, and End Results (SEER) database analyzed by Cannon et al in this issue of JAMA Otolaryngology–Head & Neck Surgery are highly relevant as the future of the Patient Protection and Affordable Care Act (ACA) becomes progressively more fragile. The authors provide objective data on improved rates of health care coverage after implementation of the ACA among patients with head and neck cancer. Reviewing the evolving payer mix is an important metric when assessing access to care. The decline in uninsured patients with head and neck cancer from 6.2% in 2013 to 3.0% in 2014 is a significant improvement. This finding does not mean that increased coverage is inexpensive, uniformly successful, or synonymous with improved patient adherence to treatment and healthier living. Although SEER survival outcomes data are not yet available for comparison of the periods before and after implementation of the ACA, this article is an important catalyst in our specialty for future study of the influence that major health policy change has on patients with head and neck cancer.
https://ift.tt/2p2D9Xw
https://ift.tt/2p2D9Xw
A Parathyroid Hemangioma of the Retropharynx
This case report describes a man in his 30s who presented with cluster headaches and migraines and was subsequently diagnosed with retropharyngeal parathyroid hemangioma.
https://ift.tt/2CR7sdu
https://ift.tt/2CR7sdu
Association of the ACA With Insurance Coverage for Head and Neck Cancer
This population-based study uses data from the Surveillance, Epidemiology, and End Results database to examine the association of the Patient Protection and Affordable Care Act with rates of insurance coverage and access to care among patients with head and neck squamous cell cancer.
https://ift.tt/2p66lwK
https://ift.tt/2p66lwK
FDG PET–CT in the Detection of Oropharyngeal Cancer Recurrence
This cohort study compares the accuracies of the initial posttreatment positron emission tomography and computed tomography between primary treatment groups and attempts to define indicators of false-positive findings in patients treated for oropharyngeal cancer.
https://ift.tt/2CRPV4R
https://ift.tt/2CRPV4R
Ultrasonographic Evaluation of Upper Airway Structures in Children With Obstructive Sleep Apnea
This single-center, observational study of children with sleep-disordered breathing measures the upper airway structures using head and neck ultrasonography and evaluates the association between these measurements and severity of obstructive sleep apnea seen on polysomnography.
https://ift.tt/2p6tuPM
https://ift.tt/2p6tuPM
Pediatric Laryngeal Expression and Surgical Treatment of IgG4-Related Disease
This case report describes a previously healthy female child who presented with several months of hoarseness, globus sensation, and dysphagia and was subsequently diagnosed with a rare form of IgG4-related disease.
https://ift.tt/2CRPM1j
https://ift.tt/2CRPM1j
Atypical Infraglottic Lesion
A cigarette smoker in his 50s with a history of hypertension, chronic kidney disease, colon adenocarcinoma, and hyperuricemia presented with an asymptomatic right vocal fold mass found incidentally during esophagogastroduodenoscopy; he denied fevers or weight loss. What is your diagnosis?
https://ift.tt/2p3ZtjF
https://ift.tt/2p3ZtjF
Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps
Publication date: Available online 13 September 2018
Source: American Journal of Otolaryngology
Author(s): Feng Wang, Yang Yang, Haihong Chen
Abstract
Objective
To evaluate the serum vitamin D level in patients with chronic rhinosinusitis with nasal polyps and its correlation with the disease severity.
Setting
Hospital of Zhejiang University.
Study design
Retrospective analysis of collected data.
Subjects and methods
Patients with chronic rhinosinusitis with or without nasal polyps who underwent endoscopic sinus surgery were recruited. Demographic information including age, gender, body mass index, smoke history, atopic status and asthma was collected. Disease severity was measured by the Lund-Mackay CT score and Sino-Nasal Outcome Test-22 score. Serum 25-hydroxyvitamin D3 was measured by enzyme-linked immunosorbent assay preoperatively.
Results
Serum 25-hydroxyvitamin D3 levels were significantly lower in patients with nasal polyps (CRSwNP, 38.2 ± 9.1 nmol/L; CRSsNP, 48.94 ± 12.1 nmol/L; control, 54.1 ± 17.1 nmol/L. p < 0.001), and the levels were significantly associated with the preoperative Sino-Nasal Outcome Test-22 score (p = 0.013), but not with the Lund-Mackay score (p = 0.126). Furthermore, serum 25-hydroxyvitamin D3 levels were associated with the subjective improvement six months postoperatively (p < 0.001),
Conclusion
Serum 25-hydroxyvitamin D3 levels are lower in Chinese CRSwNP patients. These 25-hydroxyvitamin D3 levels are associated with SNOT-22 score. Preoperative 25-hydroxyvitamin D3 level may impact on the symptom improvement after surgery.
https://ift.tt/2xkEUTV
Ultrasound guided superior laryngeal nerve block as an adjuvant to generalanesthesia during endoscopic laryngeal surgery: A prospective, randomized, double-blind trial
Publication date: Available online 13 September 2018
Source: American Journal of Otolaryngology
Author(s): Rupavath Ramkumar, Suman Arora, Nidhi Bhatia, Sandeep Bansal
Abstract
Introduction
Blindly administered bilateral (B/L) superior laryngeal nerve (SLN) blocks, have been used to decrease the perioperative stress response of endoscopic laryngosurgeries. Use of ultrasound (USG) for giving these blocks is more likely to be successful, with fewer complications. We evaluated the efficacy of USG guided B/L SLN block in decreasing perioperative cough, sore-throat and hoarseness of voice.
Material and methods
This study was conducted on forty patients undergoing endoscopic laryngosurgery under GA. Patients were randomized into two groups of 20 patients each. Patients in group C received GA, whereas those in group L received USG-guided SLN block bilaterally with 2.5 ml of 2% lignocaine, along with GA. Postoperative cough, sore throat and hoarseness of voice was measured at 30 min, 2 h, 4 h and 24 h following transfer to post-anesthesia care unit.
Results
Patients receiving SLN block had significantly lower incidence of perioperative cough (20% in group L vs 90% in group C; p value - 0.0001) as well as sore throat (5% in group L vs 95% in group C; p value - 0.0001). In these patients, severity of hoarseness of voice was greater in the early postoperative period (100% in group L vs 70% in group C; p value - 0.027), while it decreased significantly at 24 h postoperatively(0.0% in group L vs 30% in group C; p value - 0.027).
Conclusion
USG guided SLN block as an adjuvant to GA resulted in better recovery profile of the patients with significant reduction in postoperative cough, sore throat and hoarseness of voice.
https://ift.tt/2NbcA0T
Internal carotid artery dissection causing pulsatile tinnitus
Publication date: Available online 13 September 2018
Source: American Journal of Otolaryngology
Author(s): Stephanie Y. Chen, Gregory J. Zipfel, Cameron C. Wick
https://ift.tt/2xkEGMz
Differential effects of postoperative oral corticosteroid on eosinophilic vs. non-eosinophilic CRSwNP subtypes
Publication date: Available online 13 September 2018
Source: American Journal of Otolaryngology
Author(s): Kuang-Hsuan Shen, Yu-Hsuan Wang, Ting-Wei Hsu, Li-Chun Hsieh, Fang-Ju Sun, Ying-Piao Wang
Abstract
Purpose
The efficacy of postoperative oral corticosteroids on surgical outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) patients following endoscopic sinus surgery (ESS) remains controversial. This study evaluated the potential benefits of postoperative oral corticosteroids on surgical outcomes in CRSwNP patients and investigated the differential effects on eosinophilic CRSwNP (ECRSwNP) and noneosinophilic CRSwNP (NECRSwNP).
Materials and methods
Patients with bilateral CRSwNP who underwent ESS were enrolled and randomized to receive either oral prednisolone (30 mg/day) or placebo for 2 weeks after surgery. Visual analog scale (VAS) and Sino-Nasal Outcome Test 22 (SNOT-22) scores were chosen as the subjective outcomes, evaluated at preoperative baseline and 1, 3, and 6 months postoperatively. Lund-Kennedy Endoscopic Scores (LKESs) were used as the objective outcome, evaluated at preoperative baseline and at 2 weeks and 2, 3, and 6 months postoperatively.
Results
In total, 100 patients with bilateral CRSwNP were enrolled, of whom only 82 completed the 6-month follow-up. The subjective outcomes showed no significant difference at each follow-up points. Of the objective outcomes, the corticosteroid group reporting a trend of improvement in LKESs at 6 months postoperatively (p = 0.05). After stratification by tissue eosinophils, only patients with NECRSwNP (<10 eosinophils/HPF) demonstrated a significant improvement in LKESs at 3 months postoperatively (p = 0.03).
Conclusions
Postoperative oral corticosteroids did not provide additional improvements in VAS and SNOT-22 scores; nevertheless, a trend of LKES improvement was noted at 6 months postoperatively. After stratification by tissue eosinophils, this effect was significant only among NECRSwNP patients at 3 months follow-up.
https://ift.tt/2NdNfUd
Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence
Publication date: Available online 12 September 2018
Source: American Journal of Otolaryngology
Author(s): Richard A. Roberts, Alejandro Rivas, Kathryn F. Makowiec
Abstract
Objective
Benign paroxysmal positional vertigo (BPPV) is a common post-surgical finding in patients managed for superior semicircular canal dehiscence (SSCD). The posterior semicircular canal has been reported as the involved canal in the majority of cases of post-surgical BPPV, with only two cases reported of lateral canal involvement. The objective of this report is to present a case in which an anterior semicircular canal BPPV response was identified in a patient following surgical management for SSCD.
Method
This case report presents an adult with residual dizziness following surgical management of SSCD and vestibular rehabilitation therapy (VRT). During subsequent evaluation of vestibular function, a transient and torsional, down-beating nystagmus was provoked along with vertigo during Dix-Hallpike positioning to the right. This was consistent with BPPV affecting the left superior (anterior) semicircular canal.
Results
The patient was treated with a repositioning maneuver to manage anterior semicircular canal BPPV and no nystagmus response was recorded with post-repositioning Dix-Hallpike test. Review of radiographic images, obtained prior to vestibular function testing, showed a hyperintensity in the area of the left anterior semicircular canal ampulla. It was felt this was likely a bone chip from the SSCD repair that was pushing against the ampulla with further mobile debris within the canal.
Conclusion
It is reported that BPPV is a common complication in patients surgically managed for SSCD. Posterior semicircular canal BPPV is reported most often, with a couple of cases of lateral semicircular canal BPPV also reported. As far as we are aware, the current case represents the first report of anterior semicircular canal BPPV in this type of patient.
https://ift.tt/2xgjOGe
Sialendoscopy under conscious sedation versus general anesthesia. A comparative study
Publication date: Available online 12 September 2018
Source: American Journal of Otolaryngology
Author(s): Naif Bawazeer, Jean Carvalho, Idir Djennaoui, Anne Charpiot
Abstract
Objective
Sialendoscopy is a minimally invasive emerging approach, the general surgical technique has been published but many essential questions still need to be addressed with the aim of improving outcomes. For instance, should we systematically perform sialendoscopy under conscious sedation (CS) or general anesthesia (GA)? What are the limitations of CS? The objective of this study is to compare these two modalities.
Methodology
A retrospective study of 70 patients who had undergone a sialendoscopy between 2014 and 2016 (34 under GA and 36 under CS). Comparisons were made between these two groups in term of operative time, stone size and location, tolerability, operative success and post-operative pain.
Result
The patients' mean age was 45.33 years. The operative success rate among the GA group was 79.4% vs. 88.9% in the CS group (P = 0.276), while complications for both groups were comparable. All patients considered the intervention under CS to be tolerable.
Conclusion
Sialendoscopy under CS or GA demonstrated the ability to access large and distal stones among the different salivary glands with an excellent tolerability. Anesthesia type should be based on surgeon and patient preference Nevertheless, patient reassurance and surgeon experience are important to producing a good result with CS.
https://ift.tt/2NeCa5i
Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial
Publication date: Available online 12 September 2018
Source: American Journal of Otolaryngology
Author(s): Osama G. Abdel-Naby Awad, Abdel-Monem H. Hamad
Abstract
Purpose
Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
Material and methods
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Results
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
Conclusions
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.
https://ift.tt/2xaRxRm
Laryngopharyngeal reflux in obstructive sleep apnoea patients: Literature review and meta-analysis
Publication date: Available online 12 September 2018
Source: American Journal of Otolaryngology
Author(s): Giuseppe Magliulo, Giannicola Iannella, Antonella Polimeni, Marco De Vincentiis, Giuseppe Meccariello, Giampiero Gulotta, Benedetta Pasquariello, Filippo Montevecchi, Andrea De Vito, Giovanni D'agostino, Riccardo Gobbi, Giovanni Cammaroto, Claudio Vicini
Abstract
Purpose
Laryngopharyngeal reflux (LPR) is a frequent condition in Obstructive Sleep Apnoea (OSA) patients and different studies have been published in the last years about this topic. A review of the published literature regarding LPR in OSA patients has been reported. A meta-analysis to evaluate the incidence of LPR in OSA patients and correlate LPR positivity with OSA patients' characteristics has been performed.
Methods
A comprehensive review of the English language literature about LPR in OSA patients was performed using the most important electronic databases (PubMed, EMBASE, the Cochrane Library etc.). A total of 10 papers studying LPR in OSA were assessed and considered eligible for the meta-analysis.
Results
The data analysis regarding 870 identified OSA patients showed that 394 patients were LPR +, while 476 were LPR-. The meta-analysis showed no statistical difference regarding the AHI value between LPR + patients and LPR- patients (p = 0,3). Mean BMI was more higher in LPR + patients than in the patients without LPR, showing a significant statistical difference (p = 0.001).
Conclusion
Current international literature demonstrates a high incidence of LPR (45.2%) in OSA patients. The severity of AHI in OSA patients would not seem to correlate with the presence of laryngopharyngeal reflux. The OSA patients with LPR showed a higher BMI compared with LPR- patients.
https://ift.tt/2N7fpQq
Hörgeräteversorgung im Kindesalter
Zusammenfassung
Die Hörgeräteversorgung im Kindesalter stellt eine Herausforderung für alle Fachdisziplinen dar. Nach den Qualitätsvereinbarungen ist eine vergleichende Anpassung und Erprobung vor der Verordnung zwingend erforderlich. Auch die regelmäßigen Überprüfungen der Hörgeräteeinstellungen mittels In-situ- oder RECD(„real ear to coupler difference")-Messung und Einstellungsoptimierung sind als Standard in der Kinderversorgung anzustreben. HNO-Ärzte, Phoniater und Pädaudiologen, Pädakustiker (Kinderhörgeräteakustiker), Schwerhörigen- und Sonderpädagogen sollten dabei interdisziplinär zusammenarbeiten.
https://ift.tt/2xfJnXE
Magnetoresistance in an electronic cavity coupled to one-dimensional systems
Yan, C; Kumar, S; See, P; Farrer, I; Ritchie, D; Griffiths, JP; Jones, GAC; Yan, C; Kumar, S; See, P; Farrer, I; Ritchie, D; Griffiths, JP; Jones, GAC; Pepper, M; - view fewer (2018) Magnetoresistance in an electronic cavity coupled to one-dimensional systems. Applied Physics Letters , 113 (11) , Article 112101. 10.1063/1.5049936 . Green open access
https://ift.tt/2D4hvMD
How does a phonological dyslexic read words she has never seen?
Cipolotti, L; Denes, G; (1987) How does a phonological dyslexic read words she has never seen? Cogntive Neuropsychology , 4 (1) pp. 11-31. 10.1080/02643298708252032 .
https://ift.tt/2NIbVDx
Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
Daly, KG; Delser, PM; Mullin, VE; Scheu, A; Mattiangeli, V; Teasdale, MD; Hare, AJ; ... Bradley, DG; + view all Daly, KG; Delser, PM; Mullin, VE; Scheu, A; Mattiangeli, V; Teasdale, MD; Hare, AJ; Burger, J; Verdugo, MP; Collins, MJ; Kehati, R; Erek, CM; Bar-Oz, G; Pompanon, F; Cumer, T; Cakirlar, C; Mohaseb, AF; Decruyenaere, D; Davoudi, H; Cevik, O; Rollefson, G; Vigne, J-D; Khazaeli, R; Fathi, H; Doost, SB; Sorkhani, RR; Vahdati, AA; Sauer, EW; Kharanaghi, HA; Maziar, S; Gasparian, B; Pinhasi, R; Martin, L; Orton, D; Arbuckle, BS; Benecke, N; Manica, A; Horwitz, LK; Mashkour, M; Bradley, DG; - view fewer (2018) Ancient goat genomes reveal mosaic domestication in the Fertile Crescent. Science , 361 (6397) pp. 85-88. 10.1126/science.aas9411 . Green open access
https://ift.tt/2CRcp5Y
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; ... McCarthy, MI; + view all Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; Kitajima, H; Taliun, D; Rayner, NW; Guo, X; Lu, Y; Li, M; Jensen, RA; Hu, Y; Huo, S; Lohman, KK; Zhang, W; Cook, JP; Prins, BP; Flannick, J; Grarup, N; Trubetskoy, VV; Kravic, J; Kim, YJ; Rybin, DV; Yaghootkar, H; Mueller-Nurasyid, M; Meidtner, K; Li-Gao, R; Varga, TV; Marten, J; Li, J; Smith, AV; An, P; Ligthart, S; Gustafsson, S; Malerba, G; Demirkan, A; Tajes, JF; Steinthorsdottir, V; Wuttke, M; Lecoeur, C; Preuss, M; Bielak, LF; Graff, M; Highland, HM; Justice, AE; Liu, DJ; Marouli, E; Peloso, GM; Warren, HR; Afaq, S; Afzal, S; Ahlqvist, E; Almgren, P; Amin, N; Bang, LB; Bertoni, AG; Bombieri, C; Bork-Jensen, J; Brandslund, I; Brody, JA; Burtt, NP; Canouil, M; Chen, Y-DI; Cho, YS; Christensen, C; Eastwood, SV; Eckardt, K-U; Fischer, K; Gambaro, G; Giedraitis, V; Grove, ML; de Haan, HG; Hackinger, S; Hai, Y; Han, S; Tybjaerg-Hansen, A; Hivert, M-F; Isomaa, B; Jager, S; Jorgensen, ME; Jorgensen, T; Karajamaki, A; Kim, B-J; Kim, SS; Koistinen, HA; Kovacs, P; Kriebel, J; Kronenberg, F; Lall, K; Lange, LA; Lee, J-J; Lehne, B; Li, H; Lin, K-H; Linneberg, A; Liu, C-T; Liu, J; Loh, M; Magi, R; Mamakou, V; McKean-Cowdin, R; Nadkarni, G; Neville, M; Nielsen, SF; Ntalla, I; Peyser, PA; Rathmann, W; Rice, K; Rich, SS; Rode, L; Rolandsson, O; Schonherr, S; Selvin, E; Small, KS; Stancakova, A; Surendran, P; Taylor, KD; Teslovich, TM; Thorand, B; Thorleifsson, G; Tin, A; Tonjes, A; Varbo, A; Witte, DR; Wood, AR; Yajnik, P; Yao, J; Yengo, L; Young, R; Amouyel, P; Boeing, H; Boerwinkle, E; Bottinger, EP; Chowdhury, R; Collins, FS; Dedoussis, G; Dehghan, A; Deloukas, P; Ferrario, MM; Ferrieres, J; Florez, JC; Frossard, P; Gudnason, V; Harris, TB; Heckbert, SR; Howson, JMM; Ingelsson, M; Kathiresan, S; Kee, F; Kuusisto, J; Langenberg, C; Launer, LJ; Lindgren, CM; Mannisto, S; Meitinger, T; Melander, O; Mohlke, KL; Moitry, M; Morris, AD; Murray, AD; de Mutsert, R; Orho-Melander, M; Owen, KR; Perola, M; Peters, A; Province, MA; Rasheed, A; Ridker, PM; Rivadineira, F; Rosendaal, FR; Rosengren, AH; Salomaa, V; Sheu, WH-H; Sladek, R; Smith, BH; Strauch, K; Uitterlinden, AG; Varma, R; Willer, CJ; Bluher, M; Butterworth, AS; Chambers, JC; Chasman, DI; Danesh, J; van Duijn, C; Dupuis, J; Franco, OH; Franks, PW; Froguel, P; Grallert, H; Groop, L; Han, B-G; Hansen, T; Hattersley, AT; Hayward, C; Ingelsson, E; Kardia, SLR; Karpe, F; Kooner, JS; Kottgen, A; Kuulasmaa, K; Laakso, M; Lin, X; Lind, L; Liu, Y; Loos, RJF; Marchini, J; Metspalu, A; Mook-Kanamori, D; Nordestgaard, BG; Palmer, CNA; Pankow, JS; Pedersen, O; Psaty, BM; Rauramaa, R; Sattar, N; Schulze, MB; Soranzo, N; Spector, TD; Stefansson, K; Stumvoll, M; Thorsteinsdottir, U; Tuomi, T; Tuomilehto, J; Wareham, NJ; Wilson, JG; Zeggini, E; Scott, RA; Barroso, I; Frayling, TM; Goodarzi, MO; Meigs, JB; Boehnke, M; Saleheen, D; Morris, AP; Rotter, JI; McCarthy, MI; - view fewer (2018) Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics , 50 (4) pp. 559-571. 10.1038/s41588-018-0084-1 .
https://ift.tt/2NEw79f
M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila
Aalto, AL; Mohan, AK; Schwintzer, L; Kupka, S; Kietz, C; Walczak, H; Broemer, M; Aalto, AL; Mohan, AK; Schwintzer, L; Kupka, S; Kietz, C; Walczak, H; Broemer, M; Meinander, A; - view fewer (2018) M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. Cell Death & Differentiation 10.1038/s41418-018-0164-x . (In press). Green open access
https://ift.tt/2COvgid
Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria
Cesarini, E; Cerioni, L; Canonico, B; Di Sario, G; Guidarelli, A; Lattanzi, D; Savelli, D; ... Luchetti, F; + view all Cesarini, E; Cerioni, L; Canonico, B; Di Sario, G; Guidarelli, A; Lattanzi, D; Savelli, D; Guescini, M; Nasoni, MG; Bigini, N; Cuppini, R; Stocchi, V; Ambrogini, P; Papa, S; Luchetti, F; - view fewer (2018) Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria. PLoS One , 13 (8) , Article e0203001. 10.1371/journal.pone.0203001 . Green open access
https://ift.tt/2NIbqcD
Dual target strategy: a proposal to mitigate the risk of overtreatment and enhance patient satisfaction in rheumatoid arthritis
Ferreira, RJO; Ndosi, M; de Wit, M; Santos, EJF; Duarte, C; Jacobs, JWG; Machado, PM; ... da Silva, JAP; + view all Ferreira, RJO; Ndosi, M; de Wit, M; Santos, EJF; Duarte, C; Jacobs, JWG; Machado, PM; van der Heijde, D; Gossec, L; da Silva, JAP; - view fewer (2018) Dual target strategy: a proposal to mitigate the risk of overtreatment and enhance patient satisfaction in rheumatoid arthritis. Annals of the Rheumatic Diseases 10.1136/annrheumdis-2018-214199 . (In press). Green open access
https://ift.tt/2COuXnz
Sexual behaviours and sexually transmitted infection outcomes in a cohort of HIV-negative men who have sex with men attending sexual health clinics in England
Desai, S; Burns, F; Schembri, G; Williams, D; Sullivan, A; McOwan, A; Antonucci, S; ... Nardone, A; + view all Desai, S; Burns, F; Schembri, G; Williams, D; Sullivan, A; McOwan, A; Antonucci, S; Mercey, D; Hughes, G; Hart, G; Gill, ON; Nardone, A; - view fewer (2018) Sexual behaviours and sexually transmitted infection outcomes in a cohort of HIV-negative men who have sex with men attending sexual health clinics in England. International Journal of STD & AIDS 10.1177/0956462418789333 . (In press). Green open access
https://ift.tt/2NGKZEf
Modulating Memory Performance in Healthy Subjects with Transcranial Direct Current Stimulation Over the Right Dorsolateral Prefrontal Cortex
Smirni, D; Turriziani, P; Mangano, GR; Cipolotti, L; Oliveri, M; (2015) Modulating Memory Performance in Healthy Subjects with Transcranial Direct Current Stimulation Over the Right Dorsolateral Prefrontal Cortex. PLoS ONE , 10 (12) , Article e0144838. 10.1371/journal.pone.0144838 . Green open access
https://ift.tt/2CRbAKq
Inferring Automatic Test Oracles
Langdon, WB; Yoo, S; Harman, M; (2017) Inferring Automatic Test Oracles. In: Proceedings of the 2017 IEEE/ACM 10th International Workshop on Search-Based Software Testing (SBST). (pp. pp. 5-6). IEEE: Buenos Aires, Argentina. Green open access
https://ift.tt/2NE4PQn
Transurethral shear wave elastography for prostate cancer
Gómez Fernández, Antonio Jesús; (2018) Transurethral shear wave elastography for prostate cancer. Doctoral thesis (Ph.D), UCL (University College London). Green open access
https://ift.tt/2CQ1CJe
Modulating NAD+ metabolism to prevent acute kidney injury
Bulluck, H; Hausenloy, DJ; (2018) Modulating NAD+ metabolism to prevent acute kidney injury. Nature Medicine , 24 pp. 1306-1307. 10.1038/s41591-018-0181-9 .
https://ift.tt/2NG9YHB
Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor-ß
Chaigne, B; Clary, G; Le Gall, M; Dumoitier, N; Fernandez, C; Lofek, S; Chafey, P; ... Mouthon, L; + view all Chaigne, B; Clary, G; Le Gall, M; Dumoitier, N; Fernandez, C; Lofek, S; Chafey, P; Moinzadeh, P; Krieg, T; Denton, CP; Mouthon, L; - view fewer (2018) Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor-ß. Proteomics Clinical Applications , Article e1800069. 10.1002/prca.201800069 .
https://ift.tt/2CSJsH2
Visualising the search landscape of the triangle program
Langdon, WB; Veerapen, N; Ochoa, G; (2017) Visualising the search landscape of the triangle program. In: McDermott, J and Castelli, M and Sekanina, L and Haasdijk, E and García-Sánchez, P, (eds.) Genetic Programming. EuroGP 2017. (pp. pp. 96-113). Springer: Cham, Switzerland. Green open access
https://ift.tt/2NDQmUE
Language translation during disaster: A comparative analysis of five national approaches
O'Brien, S; Federici, F; Cadwell, P; Marlowe, J; Gerber, B; (2018) Language translation during disaster: A comparative analysis of five national approaches. International Journal of Disaster Risk Reduction , 31 pp. 627-636. 10.1016/j.ijdrr.2018.07.006 .
https://ift.tt/2CTSvYh
Genetic improvement: A key challenge for evolutionary computation
Langdon, WB; Ochoa, G; (2016) Genetic improvement: A key challenge for evolutionary computation. In: Proceedings of the 2016 IEEE Congress on Evolutionary Computation (CEC). (pp. pp. 3068-3075). IEEE: Vancouver, BC, Canada. Green open access
https://ift.tt/2NIbngX
Intralymphatic allergen immunotherapy against pollen allergy: A 3-year open follow-up study of 10 patients
Publication date: Available online 13 September 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Lars Ahlbeck, Emelie Ahlberg, Ulla Nyström, Janne Björkander, Maria C. Jenmalm
https://ift.tt/2MqFNjf
Food-induced anaphylaxis in infants and children
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Waheeda Samady, Jennifer Trainor, Bridget Smith, Ruchi Gupta
Abstract
Background
Recent recommendations to introduce peanut products to infants for peanut allergy prevention requires a focused assessment of infant anaphylaxis.
Objective
This study describes the symptomatology of food-induced anaphylaxis (FIA) in infants (<12 months) compared with older pediatric cohorts.
Methods
Retrospective review between June 2015 and June 2017 of children presenting with FIA at a large urban children's hospital emergency department (ED).
Results
A total of 357 cases of FIA were evaluated: 47 in infants (<12 months), 43 in toddlers (12-24 months), 96 in young children (2-6 years), and 171 in school-aged children (>6 years). Infants presented with gastrointestinal (GI) involvement more frequently than any other age group (89% vs 63% [P = .003], 60% [P < .001], and 58% [P < .001]). Additionally, infants and young children presented with skin involvement more frequently than school-aged children (94% and 91% vs 62% [P < .001]). Respiratory symptoms were more common in older cohorts (17% in infants vs 44% in young children [P < .001] and 54% in school-aged children [P < .001]). Egg and cow's milk were more common causes of FIA in infants compared with school-aged children (egg, 38% vs 1% [P < .001]; milk, 17% vs 7% [P = .03]). Only 21% of infants with FIA had eczema, and 36% had a history of food allergy.
Conclusion
Infants with FIA primarily presented with GI and skin manifestations. Egg was the most common food trigger in infants. Most infants with FIA did not have eczema or a history of food allergy.
https://ift.tt/2N9ZUal
Hepatitis B vaccine nonresponders: Possible mechanisms and solutions
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Tara Vinyette Saco, Alexandra T. Strauss, Dennis K. Ledford
Abstract
Objective
Hepatitis B (HBV) is a viral illness that chronically infects 240 million people worldwide, leads to liver disease, and increases risk of hepatocellular carcinoma. The HBV vaccine has decreased HBV infection, and it and the human papilloma virus vaccine are the only vaccines that prevent cancer. Despite the effectiveness of the HBV vaccine, some populations do not develop protective responses. The risk groups for poor response include those with immunosuppression or dialysis-dependent, end-stage renal disease. Five percent of normal people do not have a response. These subjects are deemed HBV "nonresponders." Multiple strategies to improve the immunogenicity of the HBV vaccine are currently being pursued, including vaccine adjuvants, recombinant vaccines, and immune enhancement via up-regulation of dendritic cells.
Data Sources
PubMed was searched for peer-reviewed publications published from January 1980 to September 2017.
Study Selections
Studies retrieved for inclusion summarized potential mechanisms behind HBV vaccine nonresponsiveness and potential solutions.
Results
The mechanisms behind HBV vaccine nonresponsiveness vary between each subject population. Many current and future strategies may provide protective immunity against HBV in each of these populations.
Conclusion
This review provides a background on the immunology of HBV infection, the possible immunologic mechanisms to explain HBV vaccine nonresponsiveness, current research aimed at improving vaccine effectiveness, and possible future approaches for providing nonresponders protection from HBV.
https://ift.tt/2MqFGUR
Hidden allergens in food allergy
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Mary Grace Baker, Sarah Saf, Angela Tsuang, Anna Nowak-Wegrzyn
https://ift.tt/2N85RVo
New diagnostic criteria for eosinophilic esophagitis: Will they influence our practice?
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Mirna Chehade
https://ift.tt/2MseVPz
Life in the FAST lane
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Matthew Greenhawt, John J. Oppenheimer
https://ift.tt/2N7yJx4
Allergen immunotherapy
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): John Oppenheimer, Gailen D. Marshall
https://ift.tt/2MqFuF7
Editorial Board
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s):
https://ift.tt/2Nc7GAw
Information for Authors
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s):
https://ift.tt/2MseEMx
Table of Contents
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s):
https://ift.tt/2Nc7vVS
Information for Readers
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s):
https://ift.tt/2Msercd
Diane E. Schuller, MD (1943–2018)
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Joseph A. Bellanti
https://ift.tt/2Nb8Ufp
Pilot study of the CAPS (Clinical extent, Area, Pruritus, Sleep) measure for atopic dermatitis severity
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Aaron M. Drucker, Natalie H. Matthews, Jennie Muglia, Abrar A. Qureshi
Keywords
Eczema; Atopic dermatitis; Outcome measures; Severity; Symptoms; Itch
Abbreviations: AD, atopic dermatitis; BSA, body surface area; CAPS, Clinical extent, Area, Pruritus, Sleep; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; IGA, Investigator Global Assessment; POEM, Patient-Oriented Eczema Measure
https://ift.tt/2MqEZuJ
Development of food protein–induced enterocolitis syndrome (FPIES) to egg after immunoglobulin E–mediated egg allergy
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s): Hannah Duffey, Maureen Egan
https://ift.tt/2N8V3qe
Erratum
Publication date: September 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3
Author(s):
https://ift.tt/2MqEReJ
A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC
Conditions: Squamous Cell Carcinoma of the Oropharynx; HPV16 Positive
Interventions: Biological: ISA101b; Drug: Cemiplimab; Other: Placebo
Sponsors: ISA Pharmaceuticals; Regeneron Pharmaceuticals
Not yet recruiting
https://ift.tt/2x6QAu7
Interventions: Biological: ISA101b; Drug: Cemiplimab; Other: Placebo
Sponsors: ISA Pharmaceuticals; Regeneron Pharmaceuticals
Not yet recruiting
https://ift.tt/2x6QAu7
Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer
Condition: Nasopharyngeal Carcinoma
Intervention:
Sponsors: National Cancer Centre, Singapore; Singapore General Hospital; A*Star
Recruiting
https://ift.tt/2D49jfl
Intervention:
Sponsors: National Cancer Centre, Singapore; Singapore General Hospital; A*Star
Recruiting
https://ift.tt/2D49jfl
To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer.
Conditions: Thyroid Cancer Stage IV; Radiation Toxicity
Interventions: Radiation: Intensity Modulated Radiotherapy; Procedure: Surgery alone
Sponsors: Tata Memorial Hospital; Department of Atomic Energy
Recruiting
https://ift.tt/2x9VruB
Interventions: Radiation: Intensity Modulated Radiotherapy; Procedure: Surgery alone
Sponsors: Tata Memorial Hospital; Department of Atomic Energy
Recruiting
https://ift.tt/2x9VruB
Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Interventions: Radiation: Intensity-modulated radiation therapy; Drug: Paclitaxel liposome; Drug: Cisplatin; Drug: 5-Fluorouracil
Sponsor: Sun Yat-sen University
Not yet recruiting
https://ift.tt/2CPY4Hd
Interventions: Radiation: Intensity-modulated radiation therapy; Drug: Paclitaxel liposome; Drug: Cisplatin; Drug: 5-Fluorouracil
Sponsor: Sun Yat-sen University
Not yet recruiting
https://ift.tt/2CPY4Hd
Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice
Publication date: Available online 12 September 2018
Source: Archives of Oral Biology
Author(s): Wenying Song, Yanli Wang, Qing Chu, Congcong Qi, Yuehua Gao, Yan Gao, Lili Xiang, Xu Zhenzhen, Yuguang Gao
Abstract
Objectives
In order to understand the specific in vivo function of transforming growth factor-beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a conditional knockout method. In the present study, we aimed to further understand the potential role of TGF-β1 in enamel formation.
Design
Transgenic mice withoutTGF-β1 in epithelial cells were generated. Scanning electron microscopy and micro-computed tomography analysis were used to detect the dental appearance, enamel microstructure and tooth density. Histological analysis was used to examine the residual organic matrix of enamel. Quantitative real-time polymerase chain reaction was used to analyze the expressions of enamel matrix proteins at the mRNA level.
Results
The enamel of mandibular molars and incisors inTGF-β1 conditional knockout mice displayed severe attrition and lower density compared with the wild-type littermates. A slender microstructure of enamel rod was observed, and enamel matrix proteins were retained in the enamel space at the maturation stage in conditional knockout mice. Moreover, the expressions of enamel matrix protein-encoding genes, such as amelogenin (Amelx), ameloblastin (Ambn), Enamelin (Enam) and matrix metalloproteinase-20 (Mmp-20), were increased in enamel organs of conditional knockout mice. On the other hand, the expressions of Amelotin (Amtn), kallikrein-related peptidase-4 (Klk4), C4orf26 and WD repeat-containing protein 72 (Wdr72) were dramatically decreased at the transition and maturation stages.
Conclusions
TGF-β1 played an important role in enamel mineralization through decreasing synthesis ofAmelx, Ambn and Enam and increasing synthesis of Klk4, Amtn, Corf26 and Wdr72.
https://ift.tt/2CR946Z
Masticatory hypofunction effects induced by BTXA injection of hippocampal neurons in developing rats
Publication date: Available online 12 September 2018
Source: Archives of Oral Biology
Author(s): Chi-Yang Tsai, Hsin-Ping Lee, Hung-Ming Chang, Fang-Chun Wu
Abstract
Background and objective
In clinical practice, malocclusion is often encountered during the period of growth and development of individuals. In addition to nutritional imbalance, some studies have found that mastication affects learning and memory ability. Tooth loss and masticatory hypofunction have been suggested as risk factors of Alzheimer disease. However, relatively little research has been done in developing animals. The present study evaluated the relationship between masticatory hypofunction and neuropathological changes of the hippocampus in developing rats.
Design
Four-week-old Wistar rats were randomly divided into saline-injected and botulinum toxin type A (BTXA)-injected groups. After an experiment period of 4 weeks, the rats were sacrificed for evaluation of neuropathological changes in the hippocampus through Nissl staining and phosphorylated cyclic AMP (cAMP) response element binding protein (CREB) immunohistochemistry.
Results
Nissl staining revealed a significant reduction in the density of neurons in the BTXA-injected rats. The BTXA-injected rats exhibited a decreased level of CREB phosphorylation. The degree of p-CREB immunoreactivity differed significantly between the two groups.
Conclusion
The BTXA-injected rats exhibited a reduction in neuron density and phosphorylated CREB, indicating that mastication might influence the learning and memory ability during the growth period. Therefore, it is strongly suggested that malocclusion be corrected as soon as possible during growth and development.
https://ift.tt/2x9yebD
Effectiveness and acid/tooth brushing resistance of in-office desensitizing treatments—A hydraulic conductance study
Publication date: Available online 12 September 2018
Source: Archives of Oral Biology
Author(s): Samira Helena João-Souza, Alana Cristina Machado, Raquel Mariana Lopes, Denise Maria Zezell, Tais Scaramucci, Ana Cecília Corrêa Aranha
Abstract
Objective
To evaluate dentin permeability and tubule occlusion of in-office desensitizing treatments, and to analyze their resistance to erosive/abrasive challenges.
Design
Ninety-one 1mm-thick dentin discs were immersed in EDTA solution for 5 min. After analyzing the maximum dentin permeability, the specimens were randomly allocated into 7 experimental groups (n = 10): Control (no treatment); Er,Cr:YSGG laser; Nd:YAG laser; Gluma Desensitizer ; Duraphat; Pro-Argin toothpaste; Calcium Sodium Phosphosilicate (CSP) paste. The post-treatment permeability was assessed and then the specimens were subjected to a 5-day erosion-abrasion cycling protocol: 4x/day of immersion in citric acid solution (5 min;0.3%), followed by exposure to clarified human saliva (60 min). After the first and last acid challenges, specimens were brushed for 15 s, with exposure to the toothpaste slurry for total time of 2 min. Dentin permeability was re-measured (post-cycling). Percentage of dentin permeability for each experimental time was calculated in relation to the maximum permeability (%Lp). Data were analyzed with 2-way repeated measures ANOVA and Tukey tests (α = 0.05). Surface modifications were analyzed by scanning electron microscopy.
Results
In both experimental time CSP paste and Gluma Desensitizer did not differ from each other (p = 0.0874), and were the only groups that presented significantly lower %Lp than the Control (p = 0.026 and p = 0.022, respectively). After treatment, they were able to reduce dentin permeability in 82% and 72%, respectively. The %Lp post-cycling was higher than post-treatment value for all groups (p = 0.008). Dentin permeability increased 21% for CSP paste and 12% for Gluma, but they remained significant different from Control. Deposits on the surface were observed for CSP paste; and for Gluma, tubule diameters were shown to be smaller.
Conclusions
CSP paste and Gluma Desensitizer were the only treatments able to decrease dentin permeability post-treatment and to sustain low permeability post-cycling.
https://ift.tt/2CSvwg8
Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients
Publication date: Available online 13 September 2018
Source: Clinical Immunology
Author(s): Mei Wang, Fuqiong Chen, Jingli Wang, Zhixuan Zeng, Qin Yang, Shiying Shao
Abstract
Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.
https://ift.tt/2Ojrqie
Reproductive Guidance Through Prenatal Diagnosis and Genetic Counseling for Recessive Hereditary Hearing Loss in High-risk Families
Publication date: Available online 12 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Deng Yuyuan, Sang Shushan, Wen Jie, Liu Yalan, Ling Jie, Chen Hongsheng, Cai Xinzhang, Mei Lingyun, Chen Xiaoya, Li Meng, Li Wu, Li Taoxi, He Chufeng, Feng Yong
Abstract
Objective
To evaluate the accuracy and validity of our protocol for prenatal diagnosis and genetic counseling in high-risk families at a clinic.
Methods
Fifteen unrelated families with recessive nonsyndromic hearing loss (NSHL) in their family history and a positive attitude towards prenatal diagnosis were recruited in the present study. According to genetic information for each family, Sanger sequencing, fluorescence polymerase chain reaction (PCR)-based congenital deafness gene detection kit and multiple PCR-based target gene capture and high-throughput sequencing were used. Genetic counseling was offered to all participating families by genetic counselors and otologists. Prenatal diagnosis was provided to families with detected pathogenic mutations and who were expected to participate in subsequent prenatal diagnosis.
Results
In this study, confirmed pathogenic mutations were detected in eight families, who were defined as high-risk families. These families all participated in prenatal diagnosis with positive attitudes. One novel variant (c.1687dupA) in the SLC264 gene was detected in a family. Through genetic counseling, the recurrence probability of NSHL in fetuses was 25% in six families, 0% in one family, and 50% in one family. The results of fetal DNA detection showed that one fetal variant was wild type, three were heterozygous mutations in SLC26A4, and one was a compound heterozygous mutation in SLC26A4. Two variants were heterozygous mutations in GJB2, and one was a homozygous mutation in GJB2. According to the test results for fetal DNA, prenatal diagnosis found that six fetuses had normal hearing, whereas two fetuses suffered from NSHL. After birth, six infants predicted to have normal hearing passed a newborn hearing screening test and two infants predicted to have NSHL were diagnosed with NSHL and received cochlear implants.
Conclusion
Our protocol for prenatal diagnosis and genetic counseling provides detailed information that can assist couples in high-risk families in preparing for infant arrival and future family planning. For the affected neonates, prenatal diagnosis and genetic counseling achieve an "early screening, early diagnosis, early intervention" strategy.
https://ift.tt/2MuincR
State of the art: Rehabilitation of speech and swallowing after total laryngectomy
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Joseph Zenga, Tessa Goldsmith, Glenn Bunting, Daniel G. Deschler
Abstract
Despite the development and expansion of non-surgical organ preservation therapy, total laryngectomy continues to be the optimal therapy for far-advanced local disease and the only curative option for radiotherapy failures not amenable to partial laryngeal procedures. Laryngectomy, however, remains a life-altering operation with profound effects on swallowing and speech. In the nearly 150 years since the first total laryngectomy was performed, few ablative aspects have changed, but reconstructive techniques have undergone radical evolution. This review will trace the origins of laryngeal rehabilitation for voice and swallowing, the current state of the art with attention to pre-treatment considerations and post-operative management, current surgical management techniques, and the future of functional laryngeal reconstruction.
https://ift.tt/2xa2tzc
Modification of the eight-edition tumor-node-metastasis staging system with N1b for papillary thyroid carcinoma: A multi-institutional cohort study
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Mijin Kim, Hee Kyung Kim, Hye In Kim, Eun Heui Kim, Min Ji Jeon, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Tae Hyuk Kim, Bo Hyun Kim, Tae Yong Kim, Ho-Cheol Kang, Won Bae Kim, Jae Hoon Chung, Young Kee Shong, Sun Wook Kim, Won Gu Kim
Abstract
Objectives
Based on the tumor-node-metastasis staging system, eighth edition (TNM-8), N1b is no longer used as a variable to determine final stage in papillary thyroid carcinoma (PTC). We aimed to evaluate the predictability of a simple modification of the TNM staging with N1b classification in a large multicenter thyroid cancer cohort.
Materials and methods
This study included 7717 patients with PTC who underwent thyroid surgery between 1996 and 2005 from six tertiary hospitals. We classified patients with stage II into stage IIA and IIB with modified-TNM: older patients with N1b disease were classified as stage IIB, while remaining patients were classified as stage IIA.
Results
The mean age was 46.2 years, and 24% were aged ≥55 years. In older patients, the 10-year disease-specific survival (DSS) rate of N1b disease (86.3%) was approximately 10% lower than that of N1a disease, and patients with N1b had significantly poorer DSS than those with N1a (HR = 3.3, p < 0.001). When the modified-TNM was applied, DSS curves between stage groups significantly differed (p < 0.001), and the relative risk of DSS in stage IIB patients was 2.3 times higher than in stage IIA patients (p < 0.001). The proportion of variation explained value of the modified-TNM was 4.9% and that of the TNM-8 was 4.7%.
Conclusion
This multicenter study reveals that the presence of lateral lymph node metastasis affects disease mortality in PTC, especially in older patients. The sub-classification of stage II in older patients improves DSS predictability. This simple modification of TNM-8 provides better prognostic information for patients with PTC.
https://ift.tt/2CSiCig
A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review
Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain–Barre syndrome, and pleural or pericardial effusion. A rare manifestation of hepatitis A is acute myocarditis. We report a case of a young woman who presented with "flu-like symptoms" and was found to have severe elevation of liver enzymes due to acute hepatitis A infection. On her 3rd day of admission, the patient developed chest pain and nonspecific electrocardiographic changes. Her troponins rose to 16.4 ng/mL, and a transthoracic echocardiogram revealed global hypokinesis and a depressed ejection fraction at 30%. A CT angiography showed no evidence of significant coronary artery disease. The patient was managed supportively, and symptoms and laboratory findings slowly improved over the next 7 days. Her chest pain resolved and a follow-up echocardiogram showed improved ejection fraction to 45%.
https://ift.tt/2xa73Nb
The Telomerase and Alternative Lengthening of Telomeres Mechanisms Regulate Laryngeal Cancer Cell Apoptosis via the PI3K/Akt Pathway
ORL
https://ift.tt/2xjO0QP
Unreasonable doubt: Politics and aesthetics in the crime novels of Horacio Vázquez Rial
Bollig, B.; (2018) Unreasonable doubt: Politics and aesthetics in the crime novels of Horacio Vázquez Rial. Radical Americas , 3 (1) , Article 1. 10.14324/111.444.ra.2018.v3.1.001. . Green open access
https://ift.tt/2N8wqd3
Mobile Data Repositories at the Edge.
Psaras, I; Ascigil, O; Rene, S; Pavlou, G; Afanasyev, A; Zhang, L; (2018) Mobile Data Repositories at the Edge. In: Ahmad, I and Sundararaman, S, (eds.) Proceedings of the USENIX Workshop on Hot Topics in Edge Computing HotEdge '18. USENIX Association: Boston, MA, USA. (In press). Green open access
https://ift.tt/2xa1sGQ
Controlled Organization of DNA Origami on Nano-Patterned Surfaces
Huang, D; Freeley, M; Matteo, P; (2015) Controlled Organization of DNA Origami on Nano-Patterned Surfaces. Presented at: 12th International Conference on Materials Chemistry: MC 12, University of York, UK.
https://ift.tt/2NbJo9O
Assessing the applicability of public health intervention evaluations from one setting to another: a methodological study of the usability and usefulness of assessment tools and frameworks
Burchett, HED; Blanchard, L; Kneale, D; Thomas, J; (2018) Assessing the applicability of public health intervention evaluations from one setting to another: a methodological study of the usability and usefulness of assessment tools and frameworks. Health Research Policy and Systems , 16 (1) , Article 88. 10.1186/s12961-018-0364-3 . Green open access
https://ift.tt/2xbvlXj
Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study
Agarwal, R; Rossignol, P; Garza, D; Mayo, MR; Warren, S; Arthur, S; Romero, A; ... Williams, B; + view all Agarwal, R; Rossignol, P; Garza, D; Mayo, MR; Warren, S; Arthur, S; Romero, A; White, WB; Williams, B; - view fewer (2018) Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study. American Journal of Nephrology , 48 (3) pp. 172-180. 10.1159/000492622 . Green open access
https://ift.tt/2NahdIE
Plasma cell depletion with bortezomib in the treatment of refractory N-methyl-d-aspartate (NMDA) receptor antibody encephalitis. Rational developments in neuroimmunological treatment
Keddie, S; Crisp, SJ; Blackaby, J; Cox, A; Coles, A; Hart, M; Church, AJ; ... Lunn, MP; + view all Keddie, S; Crisp, SJ; Blackaby, J; Cox, A; Coles, A; Hart, M; Church, AJ; Vincent, A; Zandi, M; Lunn, MP; - view fewer (2018) Plasma cell depletion with bortezomib in the treatment of refractory N-methyl-d-aspartate (NMDA) receptor antibody encephalitis. Rational developments in neuroimmunological treatment. European Journal of Neurology 10.1111/ene.13759 . (In press).
https://ift.tt/2xdGJBX
Exploring Human-Tech Hybridity at the Intersection of Extended Cognition and Distributed Agency: A Focus on Self-Tracking Devices
Duus, R; Cooray, M; Page, NC; (2018) Exploring Human-Tech Hybridity at the Intersection of Extended Cognition and Distributed Agency: A Focus on Self-Tracking Devices. Frontiers in Psychology | , 9 (ARTN 143) 10.3389/fpsyg.2018.01432 . Green open access
https://ift.tt/2NbJluE
Where's the leadership? Future commitments of Unicef and WHO for global child health
Costello, A; Peterson, S; Rasanathan, K; Daelmans, B; Bahl, R; (2018) Where's the leadership? Future commitments of Unicef and WHO for global child health. British Medical Journal , 362 , Article k3219. 10.1136/bmj.k3219 . Green open access
https://ift.tt/2xbv4Uh
Cell-based therapies for neural replacement strategies in stroke-related neurodegeneration: neurophysiological insights into stem progenitor cell neurogenesis within a host environment
Kopach, O; Pivneva, T; (2018) Cell-based therapies for neural replacement strategies in stroke-related neurodegeneration: neurophysiological insights into stem progenitor cell neurogenesis within a host environment. Neural Regeneration Research , 13 (8) pp. 1350-1351. 10.4103/1673-5374.235224 . Green open access
https://ift.tt/2xeVYKG
Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo
Hager, R; Arnold, A; Sevcsik, E; Schütz, GJ; Howorka, S; (2018) Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo. Langmuir 10.1021/acs.langmuir.8b01942 . (In press). Green open access
https://ift.tt/2NFK5HV
Time-resolved diffuse optical tomography system based on adaptive structured light illumination and compressive sensing detection
Farina, A; Betcke, M; Bassi, A; Valentini, G; Arridge, S; D'Andrea, C; (2018) Time-resolved diffuse optical tomography system based on adaptive structured light illumination and compressive sensing detection. In: Fournier, C and Georges, MP and Popescu, G, (eds.) Unconventional Optical Imaging. (pp. 106770D). Society of Photo-Optical Instrumentation Engineers (SPIE) Green open access
https://ift.tt/2xeVJ2e
Laws in action or action without laws? Understanding the legal and policy responses to hate crimes based on sexual orientation in Poland
Godzisz, Piotr; (2018) Laws in action or action without laws? Understanding the legal and policy responses to hate crimes based on sexual orientation in Poland. Doctoral thesis (Ph.D), UCL (University College London).
https://ift.tt/2NGIjGB
Measuring the Benefits of Decision Aids for Economic Evaluation
Butt, T; (2018) Measuring the Benefits of Decision Aids for Economic Evaluation. PharmacoEconomics - Open 10.1007/s41669-018-0087-y . (In press). Green open access
https://ift.tt/2xeVvrU
The Search for Active Marsquakes Using Subpixel Coregistration and Correlation: Best Practice and First Results
Grindrod, PM; Hollingsworth, J; Ayoub, F; Hunt, SA; (2018) The Search for Active Marsquakes Using Subpixel Coregistration and Correlation: Best Practice and First Results. Journal of Geophysical Research: Planets , 123 (7) pp. 1881-1900. 10.1029/2018JE005649 . Green open access
https://ift.tt/2NEoT5m
The International Trauma Questionnaire: development of a self-report measure of ICD-11 PTSD and complex PTSD
Cloitre, M; Shevlin, M; Brewin, CR; Bisson, JI; Roberts, NP; Maercker, A; Karatzias, T; Cloitre, M; Shevlin, M; Brewin, CR; Bisson, JI; Roberts, NP; Maercker, A; Karatzias, T; Hyland, P; - view fewer (2018) The International Trauma Questionnaire: development of a self-report measure of ICD-11 PTSD and complex PTSD. Acta Psychiatrica Scandinavica 10.1111/acps.12956 . (In press).
https://ift.tt/2xeViF8
Mechanisms of Epithelial Polarity in Drosophila
Nunes De Almeida, Francisca; (2018) Mechanisms of Epithelial Polarity in Drosophila. Doctoral thesis (Ph.D), UCL (University College London). Green open access
https://ift.tt/2NBEyCt
Dynamical systems applied to cosmology: dark energy and modified gravity
Bahamonde, S; Boehmer, CG; Carloni, S; Copeland, EJ; Fang, W; Tamanini, N; (2019) Dynamical systems applied to cosmology: dark energy and modified gravity. Physics Reports (In press).
https://ift.tt/2x7jFEE
Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function
Tierney, TM; Holmes, N; Meyer, SS; Boto, E; Roberts, G; Leggett, J; Buck, S; ... Barnes, GR; + view all Tierney, TM; Holmes, N; Meyer, SS; Boto, E; Roberts, G; Leggett, J; Buck, S; Duque-Muñoz, L; Litvak, V; Bestmann, S; Baldeweg, T; Bowtell, R; Brookes, MJ; Barnes, GR; - view fewer (2018) Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function. NeuroImage , 181 pp. 513-520. 10.1016/j.neuroimage.2018.07.035 . Green open access
https://ift.tt/2NE8tK1
RNA target recognition by IMP1 – a molecular investigation at the transcriptome level
Gallagher, Christopher; (2018) RNA target recognition by IMP1 – a molecular investigation at the transcriptome level. Doctoral thesis (Ph.D), UCL (University College London).
https://ift.tt/2xa1ezt
The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target
Petyuk, VA; Chang, R; Ramirez-Restrepo, M; Beckmann, ND; Henrion, MYR; Piehowski, PD; Zhu, K; ... Myers, AJ; + view all Petyuk, VA; Chang, R; Ramirez-Restrepo, M; Beckmann, ND; Henrion, MYR; Piehowski, PD; Zhu, K; Wang, S; Clarke, J; Huentelman, MJ; Xie, F; Andreev, V; Engel, A; Guettoche, T; Navarro, L; De Jager, P; Schneider, JA; Morris, CM; McKeith, IG; Perry, RH; Lovestone, S; Woltjer, RL; Beach, TG; Sue, LI; Serrano, GE; Lieberman, AP; Albin, RL; Ferrer, I; Mash, DC; Hulette, CM; Ervin, JF; Reiman, EM; Hardy, JA; Bennett, DA; Schadt, E; Smith, RD; Myers, AJ; - view fewer (2018) The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Brain , 141 (9) pp. 2721-2739. 10.1093/brain/awy215 . Green open access
https://ift.tt/2NHCcBQ
Aflatoxin M 1 in cow, sheep, and donkey milk produced in Sicily, Southern Italy
Abstract
Samples (n = 485) of raw (n = 394) or heat-treated (n = 91) milk of three different species (cow, n = 170; sheep, n = 133; donkey, n = 84), collected 2013–2016 in Western Sicily (Southern Italy), were analyzed for aflatoxin M1 (AFM1) by enzyme-linked immunosorbent assay (ELISA). Positive ELISA results were further analyzed by HPLC with fluorescence detection. Both methods had a detection limit for AFM1 in milk of 7 ng kg−1. ELISA yielded 12.9 and 5% positives in cows and sheep milk, respectively, all samples of donkey milk were negative. Levels of AFM1 were in most cases at 0.007–< 0.05 μg kg−1, only two samples (sheep milk) slightly exceeded the European Union maximum level of 0.05 μg kg−1. Only 6% of the samples were positive for AFM1 in a concentration range of 0.008–0.15 μg kg−1. Only milk samples collected directly from farms were positive. Overall, the levels were much lower than previously reported for Southern Italy cow and sheep milk samples purchased in retail stores. The results of this work indicate a continuous improvement of the feeding techniques on dairy farms of Southern Italy, which is essential to ensure consumers' protection.
https://ift.tt/2x7IvoZ
Versorgungsforschung in der Dermatologie 2018 – Kraft des Faktischen
Zusammenfassung
In der in Deutschland praktizierten Dermatologie ist Versorgungsforschung eine etablierte und hoch differenzierte Disziplin. In vielen universitären dermatologischen Einrichtungen und niedergelassenen Praxen werden Studien zu Vorgängen der gesundheitlichen Versorgung bei Hautkrankheiten durchgeführt. Unter dem Dach der Deutschen Dermatologischen Gesellschaft und des Berufsverbandes der Deutschen Dermatologen wird ein wesentlicher Teil der Studien und Projekte des Competenzzentrums Versorgungsforschung in der Dermatologie (CVderm) als bundesweites Referenzzentrum getragen. Wichtige Projekte sind Implementierung von Patientenregistern, Umsetzung nationaler Versorgungsstudien, Forschung mit Sekundärdaten sowie Durchführung methodischer Studien zur Weiterentwicklung wissenschaftlicher Fragestellungen. Wichtige Ergebnisse sind die nationalen Versorgungskonferenzen für Psoriasis, Hautkrebs, Wunden und Neurodermitis, die regionalen Versorgungsnetze sowie Projekte und Kooperationen mit Krankenkassen, Selbstverwaltung und öffentlichen Trägern. Im Interesse der verbesserten Patientenversorgung werden wichtige Faktoren der Versorgung laufend verbessert. Zukünftige dermatologische Versorgungsforschung wird in noch effizienterer Weise zur besseren Versorgungsplanung und -lenkung beitragen. Patientenregister werden den Transfer von Innovationen in die Versorgung erleichtern und dazu beitragen, dass neue Therapieverfahren angewendet werden können. Register unterstützen auch die Optimierung der Therapieansätze, die inzwischen beispielsweise bei Psoriasis wegen der Fülle an zur Verfügung stehenden Arzneimitteln nicht mehr allein auf der Basis klinischer Studien durchgeführt werden kann. Im Zeitalter der digitalen Medizin kommt der Versorgungsforschung eine noch wichtigere Funktion zu.
https://ift.tt/2MrhRw3
Prevention and treatment of tuberculosis infection in candidates for biologic therapy: A multidisciplinary consensus statement adapted to the dermatology patient
P. Rodríguez-Jiménez, I. Mir-Viladrich, P. Chicharro, G. Solano-López, F.J. López-Longo, C. Taxonera, P. Sánchez-Martínez, X. Martínez-Lacasa, M. García-Gasalla, J. Dorca, M. Arias-Guillén, J.M. García-García, E. Dauden
Actas Dermosifiliogr 2018;109:584-601
Abstract - Full Text - PDF
https://ift.tt/2NAeTdl
The First Year of the AEVD Primary Cutaneous Lymphoma Registry
Y. Peñate, O. Servitje, S. Machan, R. Fernández-de-Misa, M.T. Estrach, E. Acebo, J. Mitxelena, M.D. Ramón, A. Flórez, M. Blanes, M. Morillo, S. Medina, J. Bassas, A. Zayas, P. Espinosa, A. Pérez, N. Gónzalez-Romero, J.D. Domínguez, C. Muniesa, J. López Robles, A. Combalia, I. Yanguas, H. Suh, I. Polo-Rodríguez, I. Bielsa, A. Mateu, B. Ferrer, M.A. Descalzo, I. García-Doval, P.L. Ortiz-Romero
Actas Dermosifiliogr 2018;109:610-6
Abstract - Full Text - PDF
https://ift.tt/2NDY69i
Practice Models in Teledermatology in Spain: Longitudinal Study, 2009-2014
Management of Moderate to Severe Psoriasis in Routine Clinical Practice in Spanish Hospitals
Idiopathic Facial Aseptic Granuloma: Clinical and Ultrasound Findings in 3 Cases
Cervical Cellulitis of Odontogenic Origin
Pityriasis Lichenoides et Varioliformis Acuta Associated With Human Herpesvirus 7
Ulcerated Penile Lesion
Máculas evanescentes en tronco y extremidades
Quality of Life in Nonmelanoma Skin Cancer
Rare Tongue Compromising of Mucocutaneous Leishmaniasis by Leishmania Subgenus Viannia
Agminated Dermal Melanocytosis in the Territory of Ota's Nevus
Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica
Ultrasound Guidance for Implantation of Hypoglossal Nerve Stimulator in a Breast Implant Patient
The Laryngoscope, EarlyView.
https://ift.tt/2NFiLtl
Transoral robotic surgery versus upper airway stimulation in select obstructive sleep apnea patients
The Laryngoscope, EarlyView.
https://ift.tt/2MomPJP
Endoscopic resection of a chorda tympani schwannoma: A novel approach for an exceedingly rare entity
The Laryngoscope, EarlyView.
https://ift.tt/2NLcvk9
Narrow Band Imaging Endoscopy of the Nasopharynx for Malignancy: An Inter‐ and Intraobserver Study
The Laryngoscope, EarlyView.
https://ift.tt/2Ms5506
Facial Palsy‐Specific Quality of Life in 920 Patients: Correlation With Clinician‐Graded Severity and Predicting Factors
The Laryngoscope, EarlyView.
https://ift.tt/2NGg7Uh
Longitudinal Pure‐Tone Threshold Changes in the Same Subjects: Analysis of Factors Affecting Hearing
The Laryngoscope, EarlyView.
https://ift.tt/2Msr8Ur
Laser Soldering of Cartilage Graft Interposed Into a Tracheal Incision in a Porcine Model
The Laryngoscope, EarlyView.
https://ift.tt/2NDM3Zn
The Otolaryngology Match: A Bibliometric Analysis of 222 First‐Year Residents
The Laryngoscope, EarlyView.
https://ift.tt/2NH86yr
Anatomical Course of the Thyroarytenoid Branch of the Recurrent Laryngeal Nerve
The Laryngoscope, EarlyView.
https://ift.tt/2NCbFGc
What Is the Utility of Fine‐Needle Aspiration in Parotid Gland Neoplasms?
The Laryngoscope, EarlyView.
https://ift.tt/2MwlNvG
Development of a survival animal model for subglottic stenosis
The Laryngoscope, EarlyView.
https://ift.tt/2NKHY60
Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors
The Laryngoscope, EarlyView.
https://ift.tt/2MqeLZ6
Comparing Upper Airway Stimulation to Transoral Robotic Base of Tongue Resection for Treatment of Obstructive Sleep Apnea
The Laryngoscope, EarlyView.
https://ift.tt/2NKHXyY
Granulomas of the membranous vocal fold after intubation and other airway instrumentation
The Laryngoscope, EarlyView.
https://ift.tt/2MqeNjG
Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality‐of‐Life Outcomes?
The Laryngoscope, EarlyView.
https://ift.tt/2NCRLL8
Histone Variants as Stem Cell Biomarkers for Long‐Term Injection Medialization Laryngoplasty
The Laryngoscope, EarlyView.
https://ift.tt/2MqeN3a
Sudden hearing loss after cialis (tadalafil) use: A unique case of cochlear hydrops
The Laryngoscope, EarlyView.
https://ift.tt/2NCRCay
Endoscopic Posterior Cricoid Split With Graft in an Adult With Posterior Cricoid Fracture
The Laryngoscope, EarlyView.
https://ift.tt/2MtUlym
The Impact and Outreach of Soundscape Research
Kang, J; Aletta, F; (2018) The Impact and Outreach of Soundscape Research. Environments , 5 (5) , Article 58. 10.3390/environments5050058 . Green open access
https://ift.tt/2xaY929
What are the Current Priorities and Challenges for (Urban) Soundscape Research?
Aletta, F; Xiao, J; (2018) What are the Current Priorities and Challenges for (Urban) Soundscape Research? Challenges , 9 (1) , Article 16. 10.3390/challe9010016 . Green open access
https://ift.tt/2NKAiAI
Urban Soundscapes: Characterization of a Pedestrian Tourist Route in Sorrento (Italy)
Aletta, F; Brambilla, G; Maffei, L; Masullo, M; (2017) Urban Soundscapes: Characterization of a Pedestrian Tourist Route in Sorrento (Italy). Urban Science , 1 (1) , Article 4. 10.3390/urbansci1010004 . Green open access
https://ift.tt/2x9ePqF
RecPhyloXML: a format for reconciled gene trees
Duchemin, W; Gence, G; Arigon Chifolleau, A-M; Arvestad, L; Bansal, MS; Berry, V; Boussau, B; ... Daubin, V; + view all Duchemin, W; Gence, G; Arigon Chifolleau, A-M; Arvestad, L; Bansal, MS; Berry, V; Boussau, B; Chevenet, F; Comte, N; Davín, AA; Dessimoz, C; Dylus, D; Hasic, D; Mallo, D; Planel, R; Posada, D; Scornavacca, C; Szöllősi, G; Zhang, L; Tannier, É; Daubin, V; - view fewer (2018) RecPhyloXML: a format for reconciled gene trees. Bioinformatics 10.1093/bioinformatics/bty389 . (In press). Green open access
https://ift.tt/2xaQf8M
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals
Bihlmeyer, NA; Brody, JA; Smith, AV; Warren, HR; Lin, H; Isaacs, A; Liu, C-T; ... Sotoodehnia, N; + view all Bihlmeyer, NA; Brody, JA; Smith, AV; Warren, HR; Lin, H; Isaacs, A; Liu, C-T; Marten, J; Radmanesh, F; Hall, LM; Grarup, N; Mei, H; Muller-Nurasyid, M; Huffman, JE; Verweij, N; Guo, X; Yao, J; Li-Gao, R; van den Berg, M; Weiss, S; Prins, BP; van Setten, J; Haessler, J; Lyytikainen, L-P; Li, M; Alonso, A; Soliman, EZ; Bis, JC; Austin, T; Chen, Y-DI; Psaty, BM; Harrris, TB; Launer, LJ; Padmanabhan, S; Dominiczak, A; Huang, PL; Xie, Z; Ellinor, PT; Kors, JA; Campbell, A; Murray, AD; Nelson, CP; Tobin, MD; Bork-Jensen, J; Hansen, T; Pedersen, O; Linneberg, A; Sinner, MF; Peters, A; Waldenberger, M; Meitinger, T; Perz, S; Kolcic, I; Rudan, I; de Boer, RA; van der Meer, P; Lin, HJ; Taylor, KD; de Mutsert, R; Trompet, S; Jukema, JW; Maan, AC; Stricker, BHC; Rivadeneira, F; Uitterlinden, A; Volker, U; Homuth, G; Volzke, H; Felix, SB; Mangino, M; Spector, TD; Bots, ML; Perez, M; Raitakari, OT; Kahonen, M; Mononen, N; Gudnason, V; Munroe, PB; Lubitz, SA; van Duijn, CM; Newton-Cheh, CH; Hayward, C; Rosand, J; Samani, NJ; Kanters, JK; Wilson, JG; Kaab, S; Polasek, O; van der Harst, P; Heckbert, SR; Rotter, JI; Mook-Kanamori, DO; Eij-Gelsheim, M; Dorr, M; Jamshidi, Y; Asselbergs, FW; Kooperberg, C; Lehtimaki, T; Arking, DE; Sotoodehnia, N; - view fewer (2018) ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circulation: Genomic and Precision Medicine , 11 (1) , Article e001758. 10.1161/CIRCGEN.117.001758 . Green open access
https://ift.tt/2NA7kmX
A new perspective on lipid research in age-related macular degeneration
van Leeuwen, EM; Emri, E; Merle, BMJ; Colijn, JM; Kersten, E; Cougnard-Gregoire, A; Dammeier, S; ... Lengyel, I; + view all van Leeuwen, EM; Emri, E; Merle, BMJ; Colijn, JM; Kersten, E; Cougnard-Gregoire, A; Dammeier, S; Meester-Smoor, M; Pool, FM; de Jong, EK; Delcourt, C; Rodrigez-Bocanegra, E; Biarnés, M; Luthert, PJ; Ueffing, M; Klaver, CCW; Nogoceke, E; den Hollander, AI; Lengyel, I; - view fewer (2018) A new perspective on lipid research in age-related macular degeneration. Progress in Retinal and Eye Research 10.1016/j.preteyeres.2018.04.006 . (In press). Green open access
https://ift.tt/2xcoeOg
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop
Tong, A; Manns, B; Wang, AYM; Hemmelgarn, B; Wheeler, DC; Gill, J; Tugwell, P; ... Craig, JC; + view all Tong, A; Manns, B; Wang, AYM; Hemmelgarn, B; Wheeler, DC; Gill, J; Tugwell, P; Pecoits-Filho, R; Crowe, S; Harris, T; Van Biesen, WV; Winkelmayer, W; Levin, A; Thompson, A; Perkovic, V; Ju, A; Gutman, T; Bernier-Jean, A; Viecelli, A; O'Lone, E; Shen, J; Josephson, MA; Cho, Y; Sautenet, B; Tonelli, M; Craig, JC; - view fewer (2019) Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop. Kidney International (In press).
https://ift.tt/2NCT3Ww
International Liver Transplantation Consensus Statement on end-stage liver disease due to nonalcoholic steatohepatitis and liver transplantation
Tsochatzis, E; Coilly, A; Nadalin, S; Levistky, J; Tokat, Y; Ghobrial, M; Klinck, J; Tsochatzis, E; Coilly, A; Nadalin, S; Levistky, J; Tokat, Y; Ghobrial, M; Klinck, J; Berenguer, M; - view fewer (2018) International Liver Transplantation Consensus Statement on end-stage liver disease due to nonalcoholic steatohepatitis and liver transplantation. Transplantation 10.1097/TP.0000000000002433 .
https://ift.tt/2xekLP0
Early school failure predicts teenage pregnancy and marriage: A large population-based cohort study in northern Malawi
Glynn, JR; Sunny, BS; DeStavola, B; Dube, A; Chihana, M; Price, AJ; Crampin, AC; (2018) Early school failure predicts teenage pregnancy and marriage: A large population-based cohort study in northern Malawi. PLoS ONE , 13 (5) , Article e0196041. 10.1371/journal.pone.0196041 . Green open access
https://ift.tt/2NKzEmM
Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication
Tunnacliffe, E; Corrigan, AM; Chubb, JR; (2018) Promoter-mediated diversification of transcriptional bursting dynamics following gene duplication. Proceedings of the National Academy of Sciences of the United States of America , 115 (33) pp. 8364-8369. 10.1073/pnas.1800943115 .
https://ift.tt/2xaY3aN
'Without the Captain': Iuliu Maniu and the Romanian Legionary Movement after the death of Corneliu Zelea Codreanu
Haynes, RA; (2019) 'Without the Captain': Iuliu Maniu and the Romanian Legionary Movement after the death of Corneliu Zelea Codreanu. Slavonic and East European Review (In press).
https://ift.tt/2NH5ZdU
The many disguises of the signalling endosome
Villarroel-Campos, D; Schiavo, G; Lazo, OM; (2018) The many disguises of the signalling endosome. FEBS Letters 10.1002/1873-3468.13235 .
https://ift.tt/2xcpFvZ
Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator
Anderson, LA; Hesse, LL; Pilati, N; Bakay, WMH; Alvaro, G; Large, CH; McAlpine, D; ... Linden, JF; + view all Anderson, LA; Hesse, LL; Pilati, N; Bakay, WMH; Alvaro, G; Large, CH; McAlpine, D; Schaette, R; Linden, JF; - view fewer (2018) Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator. Hearing Research , 365 pp. 77-89. 10.1016/j.heares.2018.04.012 .
https://ift.tt/2NF6IfG
Assessment of mentalizing
Luyten, P; Malcorps, S; Fonagy, P; Ensink, K; (2019) Assessment of mentalizing. In: Bateman, A and Fonagy, P, (eds.) Handbook of mentalizing in mental health practice. American Psychiatric Association Publishing: Washington DC, USA. (In press).
https://ift.tt/2x6Q7qS
3D printing of drug-loaded gyroid lattices using selective laser sintering
Fina, F; Goyanes, A; Madla, CM; Awad, A; Trenfield, SJ; Kuek, JM; Patel, P; ... Basit, AW; + view all Fina, F; Goyanes, A; Madla, CM; Awad, A; Trenfield, SJ; Kuek, JM; Patel, P; Gaisford, S; Basit, AW; - view fewer (2018) 3D printing of drug-loaded gyroid lattices using selective laser sintering. International Journal of Pharmaceutics , 547 (1-2) pp. 44-52. 10.1016/j.ijpharm.2018.05.044 .
https://ift.tt/2NL0JGt
Cities Made of Boundaries
Vis, B.N.; (2018) Cities Made of Boundaries. [Book]. UCL Press: London, UK. Green open access
https://ift.tt/2xekITk
Langerhans cells express human β‐defensin 3: relevance for immunity during skin ageing
British Journal of Dermatology, EarlyView.
https://ift.tt/2x5rQCo
Variation in daily ultraviolet light exposure and sun protection behaviours of melanoma survivors: an observational single‐arm pilot study with a wearable sensor
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2CQeKhz
GM‐CSF as a therapeutic target in psoriasis: randomised, controlled investigation using namilumab – a specific, human anti‐GM‐CSF monoclonal antibody
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2x5Bogu
Impact of Helicobacter pylori and/or Helicobacter pylori‐related metabolic syndrome on gastroesophageal reflux disease‐ Barrett's esophagus‐ esophageal adenocarcinoma sequence
Helicobacter, EarlyView.
https://ift.tt/2xc9sXN
Εγγραφή σε:
Αναρτήσεις (Atom)