Medicine by Sfakianakis Alexandros: 05/01/18

Τρίτη 1 Μαΐου 2018

Symptom control in chronic rhinosinusitis is an independent predictor of productivity loss

Publication date: Available online 1 May 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A.P. Campbell, L.P. Hoehle, K.M. Phillips, D.S. Caradonna, S.T. Gray, A.R. Sedaghat
AimsSinonasal symptoms cause significant productivity losses in patients with chronic rhinosinusitis (CRS). Patient-perceived CRS symptom control is a longitudinal measure of CRS symptomatology and is directly associated with general health-related quality of life (QOL) in patients with CRS. The aim of this study was to better understand the relationship between symptom control and productivity loss in CRS.Materials and methodsProspective cross-sectional cohort study of 200 patients with CRS. Patients categorized their CRS symptom control as "Not at all", "A little", "Somewhat", "Very", and "Completely". Lost productivity was assessed by determining the number of work and/or school days missed in the last 3 months due to CRS symptoms. Sinonasal symptom severity was measured using the 22-item Sinonasal Outcomes Test (SNOT-22). Associations were sought between lost productivity and patient-perceived CRS symptom control.ObjectiveTo determine the association between patient-perceived longitudinal symptom control and productivity in patients with CRS.ResultsA total of 200 participants (48% male, 52% female), with a mean age of 52 years (Standard Deviation [SD]: 16) were enrolled. The mean SNOT-22 score of participants was 33.5 (SD: 22.4). Participants missed a mean of 3 days (SD: 10) of work or school due to CRS. CRS symptom control classified as "not at all" was associated with 11 days of lost productivity due to CRS on univariate analysis (β=11.16, 95% CI: 5.39–16.94, P<0.001) and 8 days of lost productivity on multivariate analysis (β=8.02, 95% CI: 1.92–14.13, P=0.011). None of the other categories of patient-reported CRS symptom control were associated with lost productivity due to CRS.ConclusionsPatient-perceived control of CRS symptoms, an important metric previously shown to be significantly associated with QOL in CRS patients, is independently associated with lost productivity. These results motivate longitudinal studies to determine if improvement of CRS symptom control may reduce losses in productivity.

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Improving influenza vaccines: challenges to effective implementation

Fan Zhou | Mai-Chi Trieu | Richard Davies | Rebecca Jane Cox

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Endocytosis regulation by autophagy proteins in MHC restricted antigen presentation

Role of calcium permeable channels in dendritic cell migration

Pablo J Sáez | Juan C Sáez | Ana-María Lennon-Duménil | Pablo Vargas

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Raising a Strong Confident Woman

My daughter, my oldest, just turned 15. It has been several years since she requested a homemade birthday cake. We celebrate now with a trip to Starbucks and dinner out with her friends. My husband and I are relegated to a table just out of sight.

I am proud of the woman my daughter is becoming. She was born when I was a medical student. When she was a toddler, I was working 80 hour weeks in the hospital. As a working mom, I wanted to show her that my work had value; my work was important and meaningful, to myself and others. I wanted to show her that women could be doctors and command the same respect as men. I hoped to lead by example and empower her with self-confidence. I wanted her to have the skills needed to stand up for herself and her friends. I wanted her to be able to recognize when something was wrong and to do something about it. As college is rapidly approaching and her time under my roof is diminishing, I can only hope that I have done enough.

It has been about 6 months since #MeToo started trending. This viral response intended to demonstrate the ubiquity of sexual harassment and inequality in the workplace has become a defining movement for my daughter's generation. It also raises the question for my generation as to how to raise a daughter in the age of #MeToo.

How to Raise a Strong, Confident Woman

• Help her explore her passions. She will learn perseverance and become self-confident after overcoming challenges.
• Praise her efforts, not her appearance.
• Allow her to make her own choices and solve her own problems. Guide her with coping skills rather than solutions.
• Point out female role models.
• Allow her to disagree with you. Teach her to explain her point of view and how to argue her point.
• Discuss media messages. Point out stereotypes.
• Discuss sex and sexuality. Discuss the role that sex plays in a loving relationship.
• Take time to listen and make yourself available to talk.

Watching my daughter and her friends, it is easy to wonder where the years have gone. However, rather than feel nostalgic about what has been, I'm excited for what is to come.

The post Raising a Strong Confident Woman appeared first on ChildrensMD.

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International Comparison of Abdominal Fat Distribution Among Four Populations: The ERA-JUMP Study

Metabolic Syndrome and Related Disorders, Volume 16, Issue 4, Page 166-173, May 2018.

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Correction for Haȷ-Dahman et al,. Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses [Correction]

NEUROSCIENCE Correction for "Fatty-acid–binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses," by Samir Haj-Dahmane, Roh-Yu Shen, Matthew W. Elmes, Keith Studholme, Martha P. Kanjiya, Diane Bogdan, Panayotis K. Thanos, Jeremy T. Miyauchi, Stella E. Tsirka, Dale G. Deutsch, and Martin Kaczocha, which was first published March 12,...

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Correction for Alder et al., Diagnostic utility of telomere length testing in a hospital-based setting [Correction]

MEDICAL SCIENCES Correction for "Diagnostic utility of telomere length testing in a hospital-based setting," by Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, James F. Casella,...

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Deep learning improves prediction of drug-drug and drug-food interactions [Systems Biology]

Drug interactions, including drug–drug interactions (DDIs) and drug–food constituent interactions (DFIs), can trigger unexpected pharmacological effects, including adverse drug events (ADEs), with causal mechanisms often unknown. Several computational methods have been developed to better understand drug interactions, especially for DDIs. However, these methods do not provide sufficient details beyond the...

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DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity [Systems Biology]

An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity. Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies. Single-cell technologies are now available to guide effective drug combinations by accounting for...

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Drought delays development of the sorghum root microbiome and enriches for monoderm bacteria [Plant Biology]

Drought stress is a major obstacle to crop productivity, and the severity and frequency of drought are expected to increase in the coming century. Certain root-associated bacteria have been shown to mitigate the negative effects of drought stress on plant growth, and manipulation of the crop microbiome is an emerging...

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Desynchronization of slow oscillations in the basal ganglia during natural sleep [Neuroscience]

Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local...

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Polysialic acid is a cellular receptor for human adenovirus 52 [Microbiology]

Human adenovirus 52 (HAdV-52) is one of only three known HAdVs equipped with both a long and a short fiber protein. While the long fiber binds to the coxsackie and adenovirus receptor, the function of the short fiber in the virus life cycle is poorly understood. Here, we show, by...

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Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species [Microbiology]

Bacterial genomes encode numerous cryptic biosynthetic gene clusters (BGCs) that represent a largely untapped source of drugs or pesticides. Mining of the cryptic products is limited by the unavailability of streamlined genetic tools in native producers. Precise genome engineering using bacteriophage recombinases is particularly useful for genome mining. However, recombinases...

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Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-{beta} signaling [Medical Sciences]

The discovery that endoplasmic reticulum (ER) luminal chaperones such as GRP78/BiP can escape to the cell surface upon ER stress where they regulate cell signaling, proliferation, apoptosis, and immunity represents a paradigm shift. Toward deciphering the mechanisms, we report here that, upon ER stress, IRE1α binds to and triggers tyrosine...

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MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis [Immunology and Inflammation]

Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent colorectal tumorigenesis in a mouse...

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Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla [Evolution]

The LTR retrotransposon Steamer is a selfish endogenous element in the soft-shell clam genome that was first detected because of its dramatic amplification in bivalve transmissible neoplasia afflicting the species. We amplified and sequenced related retrotransposons from the genomic DNA of many other bivalve species, finding evidence of horizontal transfer...

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Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell [Biophysics and Computational Biology]

In general, small proteins rapidly fold on the timescale of milliseconds or less. For proteins with a substantial volume difference between the folded and unfolded states, their thermodynamic equilibrium can be altered by varying the hydrostatic pressure. Using a pressure-sensitized mutant of ubiquitin, we demonstrate that rapidly switching the pressure...

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PDCD5 says no to NO [Cell Biology]

Blood vessels are more than mere conduits, and their dynamic function is regulated to a large extent by their inner layer, the endothelium. Endothelial cell-derived nitric oxide (NO), a product of endothelial NO synthase (eNOS), is important for normal endothelial function and vascular health. Programmed cell death 5 (PDCD5) is...

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LSD1 activates a lethal prostate cancer gene network independently of its demethylase function [Cell Biology]

Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new treatments targeting molecular pathways enriched in lethal...

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eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex [Biochemistry]

The eukaryotic 43S preinitiation complex (PIC), bearing initiator methionyl transfer RNA (Met-tRNAi) in a ternary complex (TC) with eukaryotic initiation factor 2 (eIF2)-GTP, scans the mRNA leader for an AUG codon in favorable context. AUG recognition evokes rearrangement from an open PIC conformation with TC in a "POUT" state to...

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DNA methylation and transcriptome aberrations mediated by ER{alpha} in mouse seminal vesicles following developmental DES exposure [Cell Biology]

Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the reproductive tract of adult mice. Estrogen receptor alpha (ERα) plays a role in mediating these developmental effects. However, the developmental mechanism is not well known in male tissues. Here, we present...

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LSD1: A single target to combat lineage plasticity in lethal prostate cancer [Cell Biology]

Prostate cancer initiation and progression to a lethal metastatic castration-resistant (mCRPC) phenotype remains largely dependent on the function of the androgen receptor (AR) (1). Recently, however, more potent androgen-deprivation therapy (ADT) regimens that target the AR and the androgen biosynthesis pathways have led to the emergence, in a subset of...

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Nuclear export of ubiquitinated proteins via the UBIN-POST system [Cell Biology]

Although mechanisms for protein homeostasis in the cytosol have been studied extensively, those in the nucleus remain largely unknown. Here, we identified that a protein complex mediates export of polyubiquitinated proteins from the nucleus to the cytosol. UBIN, a ubiquitin-associated (UBA) domain-containing protein, shuttled between the nucleus and the cytosol...

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Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM [Genetics]

CRISPR/Cas9-based transcriptional activation (CRISPRa) has recently emerged as a powerful and scalable technique for systematic overexpression genetic analysis in Drosophila melanogaster. We present flySAM, a potent tool for in vivo CRISPRa, which offers major improvements over existing strategies in terms of effectiveness, scalability, and ease of use. flySAM outperforms existing...

https://ift.tt/2rdMVqp

Plasmodium-associated changes in human odor attract mosquitoes [Ecology]

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission. Indeed, naturally Plasmodium-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate Plasmodium-induced increases in the attractiveness of skin odor...

https://ift.tt/2jkj6AY

Wernekink commissure syndrome with palatal myoclonus at onset: a case report and review of the literature

Wernekink commissure syndrome causes a peculiar combination of internuclear ophthalmoplegia, dysarthria, and delayed-onset palatal myoclonus. Palatal myoclonus is thought to be secondary to delayed hypertrophi...

https://ift.tt/2HGbTdg

FDA Approves Adjuvant Combo for BRAF+ Melanoma

The two targeted therapies, dabrafenib and trametinib, are already approved in combination in the metastatic setting.
FDA Approvals

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Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia

Albuquerque, A; Sheaff, M; Stirrup, O; Cappello, C; Bowring, J; Cuming, T; de Masi, A; ... Nathan, M; + view all Albuquerque, A; Sheaff, M; Stirrup, O; Cappello, C; Bowring, J; Cuming, T; de Masi, A; Rosenthal, AN; Nathan, M; - view fewer (2018) Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia. Clinical Infectious Diseases , Article ciy273. 10.1093/cid/ciy273 . (In press).

https://ift.tt/2FwoSZb

Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance

Germovsek, E; Barker, CIS; Sharland, M; Standing, JF; (2018) Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance. Clinical Pharmacokinetics 10.1007/s40262-018-0659-0 . (In press). Green open access

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Performance of Digital Back-Propagation in Kramers-Kronig Direct-Detection Receivers

Li, Z; Galdino, L; Xu, T; Erkilinç, MS; Shi, K; Sillekens, E; Thomsen, BC; ... Killey, RI; + view all Li, Z; Galdino, L; Xu, T; Erkilinç, MS; Shi, K; Sillekens, E; Thomsen, BC; Bayvel, P; Killey, RI; - view fewer (2018) Performance of Digital Back-Propagation in Kramers-Kronig Direct-Detection Receivers. In: (Proceedings) Optical Fiber Communication Conference 2018. (pp. Tu2D.4-Tu2D.4). Optical Society of America

https://ift.tt/2Fy2Gxt

Electrochemical Characterisation of Bio-Bottle-Voltaic (BBV) Systems Operated with Algae and Built with Recycled Materials

Bateson, P; Fleet, JEH; Riseley, AS; Janeva, E; Marcella, AS; Farinea, C; Kuptsova, M; ... Parker, BM; + view all Bateson, P; Fleet, JEH; Riseley, AS; Janeva, E; Marcella, AS; Farinea, C; Kuptsova, M; Conde Pueyo, N; Howe, CJ; Bombelli, P; Parker, BM; - view fewer (2018) Electrochemical Characterisation of Bio-Bottle-Voltaic (BBV) Systems Operated with Algae and Built with Recycled Materials. Biology , 7 (2) , Article 26. 10.3390/biology7020026 . Green open access

https://ift.tt/2Ku3do8

Multi-Task Learning Improves Disease Models from Web Search

Zou, B; Lampos, V; Cox, I; (2018) Multi-Task Learning Improves Disease Models from Web Search. In: WWW '18 Proceedings of the 2018 World Wide Web Conference. (pp. pp. 87-96). International World Wide Web Conferences Steering Committee Green open access

https://ift.tt/2Fy2u1d

Enhanced perceptual processing of self-generated motion: Evidence from steady-state visual evoked potentials

Wen, W; Brann, E; Di Costa, S; Haggard, P; (2018) Enhanced perceptual processing of self-generated motion: Evidence from steady-state visual evoked potentials. NeuroImage , 175 pp. 438-448. 10.1016/j.neuroimage.2018.04.019 . Green open access

https://ift.tt/2Ku3d7C

Enteric Neural Stem Cell Therapies for Enteric Neuropathies

McCann, C; Thapar, N; (2018) Enteric Neural Stem Cell Therapies for Enteric Neuropathies. Neurogastroenterology and Motility , Article e13369. 10.1111/nmo.13369 . (In press). Green open access

https://ift.tt/2FuX5rL

The use of funnel plots with regression as a tool to visually compare HIV treatment outcomes between centres adjusting for patient characteristics and size: a UK Collaborative HIV Cohort study

Gompels, M; Michael, S; Jose, S; Hill, T; Trevelion, R; Sabin, CA; May, MT; (2018) The use of funnel plots with regression as a tool to visually compare HIV treatment outcomes between centres adjusting for patient characteristics and size: a UK Collaborative HIV Cohort study. HIV Medicine 10.1111/hiv.12604 . (In press). Green open access

https://ift.tt/2Kv6UJU

Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review

Ngoepe, MN; Frangi, AF; Byrne, JV; Ventikos, Y; (2018) Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review. Frontiers in Physiology , 9 (306) 10.3389/fphys.2018.00306 . Green open access

https://ift.tt/2FwVQZ6

Climatic globalities: Assembling the problems of global climate change

Randalls, S; (2016) Climatic globalities: Assembling the problems of global climate change. In: van Munster, R and Sylvest, C, (eds.) The politics of globality since 1945: Assembling the planet. (pp. 145-163). Routledge Green open access

https://ift.tt/2KpG4TA

The development of autistic social traits across childhood and adolescence in males and females

Mandy, W; Pellicano, L; St Pourcain, B; Skuse, D; Heron, J; (2018) The development of autistic social traits across childhood and adolescence in males and females. Journal of Child Psychology and Psychiatry 10.1111/jcpp.12913 . (In press).

https://ift.tt/2FwJTTs

Southbank Skateboarding, London and Urban Culture: the Undercroft, Hungerford Bridge and House of Vans

Borden, IM; (2015) Southbank Skateboarding, London and Urban Culture: the Undercroft, Hungerford Bridge and House of Vans. In: Lombard, KJ, (ed.) Skateboarding: Subcultures, Sites and Shifts. (pp. 91-107). Routledge: Abingdon, United Kingdom. Green open access

https://ift.tt/2KrcUn7

Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

Dobson, AJ; He, X; Blanc, E; Bolukbasi, E; Feseha, Y; Yang, M; Piper, MDW; (2018) Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction. npj Aging and Mechanisms of Diseasevolume , 4 , Article 5. 10.1038/s41514-018-0024-4 . Green open access

https://ift.tt/2FxmnWl

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Kidger, AM; Sipthorp, J; Cook, SJ; (2018) ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway. Pharmacology and Therapeutics 10.1016/j.pharmthera.2018.02.007 . (In press).

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Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex

Dipoppa, M; Ranson, A; Krumin, M; Pachitariu, M; Carandini, M; Harris, KD; (2018) Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex. Neuron 10.1016/j.neuron.2018.03.037 . (In press). Green open access

https://ift.tt/2FwuQsT

Voluntary inhibitory motor control over involuntary tic movements

Ganos, C; Rothwell, J; Haggard, P; (2018) Voluntary inhibitory motor control over involuntary tic movements. Movement Disorders 10.1002/mds.27346 . (In press).

https://ift.tt/2KpSF9o

Voluntary inhibition of involuntary groaning in progressive supranuclear palsy

Mainka, T; Hidding, U; Buhmann, C; Haggard, P; Ganos, C; (2018) Voluntary inhibition of involuntary groaning in progressive supranuclear palsy. Movement Disorders Clinical Practice 10.1002/mdc3.12598 . (In press).

https://ift.tt/2FybFPh

Behaviour of Axially Restrained Concrete Slabs

Al-Hassani, Hisham Mohammed; (1978) Behaviour of Axially Restrained Concrete Slabs. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2KsmEgN

Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and Neck

Condition: Squamous Cell Carcinoma of the Head and Neck
Intervention: Radiation: Intensity Modulated Proton Therapy (IMPT) +/- Chemotherapy
Sponsors: Leiden University Medical Center; Holland Particle Therapy Centre (HollandPTC)
Not yet recruiting

https://ift.tt/2KuY7HU

Angiogenesis Inhibitors

A fact sheet that describes cancer-fighting agents that block the growth of blood vessels that support tumor growth.

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Researchers Call for Tougher Standards for Studies on Obesity Policies

When a new park is built, a tax is instituted on fast food or a ban put in place against soft drinks in a school, public health researchers must often rely on "after the fact" observational studies to evaluate the impact of such efforts on rates of obesity in a particular population and try to clearly identify and measure the factors that worked or didn't.

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Rhyme in the Odes of Horace

Blackett, Alfred Wilkinson; (1962) Rhyme in the Odes of Horace. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Utility of concurrent direct laryngoscopy and bronchoscopy with drug induced sleep endoscopy in pediatric patients with obstructive sleep apnea

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Morgan Bliss, Swati Yanamadala, Peter Koltai
ObjectivesThe goal of this report was to find the frequency of synchronous airway lesions (SAL) identified during microdirect laryngoscopy and bronchoscopy (MDLB) that influenced treatment decisions beyond the information provided by drug induced sleep endoscopy (DISE) alone in children with obstructive sleep apnea (OSA) at a tertiary care pediatric hospital.MethodsThis was a retrospective chart review of all pediatric patients who underwent drug induced sleep endoscopy in conjunction with direct laryngoscopy and bronchoscopy as part of a comprehensive airway evaluation for obstructive sleep apnea at a tertiary care pediatric hospital.ResultsThree hundred thirty-five patients with obstructive sleep apnea were evaluated with both sleep endoscopy and direct laryngoscopy with bronchoscopy. Five percent of patients had SAL identified on MDLB contributing to airway obstruction. Three patients (0.9%) who underwent MDLB for OSA required surgical correction of SAL that was identified.ConclusionIn a limited subset of patients, direct laryngoscopy with bronchoscopy provides additional positive findings to aid with treatment planning for obstructive sleep apnea.

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State of deaf children in West Bengal, India: What can be done to improve outcome

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Suniti Chakrabarti
ObjectivePrelingual deafness in children demands urgent action as best outcome is dependent on earliest possible diagnosis and intervention. Objective of this study was to determine age of suspicion, diagnosis, intervention, and outcome in a representative group of deaf children in West Bengal, India, and suggest ways of improving these parameters.MethodsIn this cross-sectional study, ages of suspicion, diagnosis, intervention and outcome of 303 randomly selected deaf children were elicited from a cohort of 1316 children with deafness identified in an earlier study.ResultsMedian ages of suspicion, diagnosis and amplification were 18, 72 and 84 months respectively. Age of suspicion was significantly related to parental education (p < 0.05); age of diagnosis to parental education and socio-economic status (p < 0.001) and children's geographic location (p < 0.01). Following diagnosis, 86% of children received hearing aids but only 6% used their aids consistently; 86% were non-verbal, 12% could communicate with a mixture of speech and gesture and only 2% with speech alone.ConclusionCurrent situation of deaf children in West Bengal, and evidence indicates, in much of India, is insupportable. However, widely diverse socio-economic conditions and scarcity of public health infrastructure preclude one solution of the problem for the whole country. In absence of the ideal universal newborn hearing screening, rigorously monitored and costed pilot programs of different models of early detection and intervention using newborn hearing screening, targeted screening and trial of calibrated noisemakers by primary care workers should be tried to see which works best where, so that successful programs can be scaled up over time.

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Head and neck presentation of Gardner Syndrome: A pediatric case series

Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Dawn Goral, Julie Highland, Mark A. Lovell, Kenny H. Chan

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Pre-operative evaluation of the adult patient undergoing elective noncardiac surgery: updated guideline from the European Society of AnaesthesiologyDirection and not directives

No abstract available

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Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology

The purpose of this update of the European Society of Anaesthesiology (ESA) guidelines on the pre-operative evaluation of the adult undergoing noncardiac surgery is to present recommendations based on the available relevant clinical evidence. Well performed randomised studies on the topic are limited and therefore many recommendations rely to a large extent on expert opinion and may need to be adapted specifically to the healthcare systems of individual countries. This article aims to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthesiologists all over Europe to integrate – wherever possible – this knowledge into daily patient care. The Guidelines Committee of the ESA formed a task force comprising members of the previous task force, members of ESA scientific subcommittees and an open call for volunteers was made to all individual active members of the ESA and national societies. Electronic databases were searched from July 2010 (end of the literature search of the previous ESA guidelines on pre-operative evaluation) to May 2016 without language restrictions. A total of 34 066 abtracts were screened from which 2536 were included for further analysis. Relevant systematic reviews with meta-analyses, randomised controlled trials, cohort studies, case-control studies and cross-sectional surveys were selected. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to assess the level of evidence and to grade recommendations. The final draft guideline was posted on the ESA website for 4 weeks and the link was sent to all ESA members, individual or national (thus including most European national anaesthesia societies). Comments were collated and the guidelines amended as appropriate. When the final draft was complete, the Guidelines Committee and ESA Board ratified the guidelines.

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Anaesthesia in High-Risk Patients

No abstract available

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A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth

Valet, C; Levade, M; Chicanne, G; Bilanges, B; Cabou, C; Viaud, J; Gratacap, M-P; ... Severin, S; + view all Valet, C; Levade, M; Chicanne, G; Bilanges, B; Cabou, C; Viaud, J; Gratacap, M-P; Gaits-Iacovoni, F; Vanhaesebroeck, B; Payrastre, B; Severin, S; - view fewer (2017) A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth. Blood , 130 (18) pp. 2032-2042. 10.1182/blood-2017-04-781641 .

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Diabetes Mellitus and Latent Tuberculosis infection: Baseline analysis of a large UK Cohort

Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; ... Abubakar, I; + view all Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; Deeks, JJ; Imran, A; Kon, OM; Mpofu, S; Nikolayevskyy, V; Rees-Roberts, M; Sitch, A; Sridhar, S; Tsou, C-Y; Whitworth, H; Abubakar, I; - view fewer (2018) Diabetes Mellitus and Latent Tuberculosis infection: Baseline analysis of a large UK Cohort. Thorax 10.1136/thoraxjnl-2017-211124 . (In press).

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How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis

Tomita, K; (2018) How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis. Current Genetics 10.1007/s00294-018-0836-6 . (In press). Green open access

https://ift.tt/2jhp9Gu

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C

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Impacts 2 years after a scalable early childhood development intervention to increase psychosocial stimulation in the home: A follow-up of a cluster randomised controlled trial in Colombia

Andrew, A; Attanasio, O; Fitzsimons, E; Grantham-McGregor, S; Meghir, C; Rubio-Codina, M; (2018) Impacts 2 years after a scalable early childhood development intervention to increase psychosocial stimulation in the home: A follow-up of a cluster randomised controlled trial in Colombia. PLoS Medicine , 15 (4) , Article e1002556. 10.1371/journal.pmed.1002556 . Green open access

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Neonatal immunization: Rationale, Current State, and Future Prospects

Whittaker, E; Goldblatt, D; McIntyre, P; Levy, O; (2018) Neonatal immunization: Rationale, Current State, and Future Prospects. [Review]. Frontiers in Immunology , 9 , Article 532. 10.3389/fimmu.2018.00532 . Green open access

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NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program

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Factors associated with medication adherence in school-aged children with asthma

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Reducing unplanned hospital admissions in patients with neuromuscular diseases: an NHS Re-audit

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Altered White-Matter Microstructure in Conduct Disorder Is Specifically Associated with Elevated Callous-Unemotional Traits

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Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction

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Effects of cleaning methods upon preservation of stable isotopes and trace elements in shells of Cyprideis torosa (Crustacea, Ostracoda): Implications for palaeoenvironmental reconstruction

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Schelling: Introduction

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German Idealism, Classical Pragmatism, and Kant's Third Critique

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Review: Acquiring Sociolinguistic Variation (2017). Eds G. De Vogelaer, M. Katerbow

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The effect of transport accessibility on the social inclusion of wheelchair users: A mixed method analysis

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Crossover from itinerant to localized magnetic excitations through the metal-insulator transition in NaOsO3

Vale, JG; Calder, S; Donnerer, C; Pincini, D; Shi, YG; Tsujimoto, Y; Yamaura, K; ... McMorrow, DF; + view all Vale, JG; Calder, S; Donnerer, C; Pincini, D; Shi, YG; Tsujimoto, Y; Yamaura, K; Moretti Sala, M; van den Brink, J; Christianson, AD; McMorrow, DF; - view fewer (2018) Crossover from itinerant to localized magnetic excitations through the metal-insulator transition in NaOsO3. Physical Review B (In press).

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