Clinical &Experimental Allergy, EarlyView.
https://ift.tt/2H4AlEM
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Δευτέρα 16 Απριλίου 2018
Simultaneously elevated FeNO and blood eosinophils relate to asthma morbidity in asthmatics from NHANES 2007‐12
Erythrodermic psoriasis and secukinumab: Our clinical experience
Dermatologic Therapy, EarlyView.
https://ift.tt/2HxW874
To Study the Role of FNAC in Pre-operative Diagnostic Work Up and Management in Parotid Tumours
Abstract
Parotid gland is an important major salivary gland connected to the oral cavity. Salivary gland tumours are infrequent around less than 3% of head and neck tumours. Parotid gland is the most common site for the occurrence of salivary tumors. They are heterogeneous group of neoplasm characterized by the varying histological features and clinical behaviour. In our study we have examined the role of FNAC for preoperative diagnostic and management. We have concluded that Fine needle aspiration cytology is advocated routinely to know the type and nature of the tumour as an important pre-operatively diagnostic work up. It helps in preoperative identification of type of tumour neoplastic or benign, preoperative counselling of patient, planning of management of tumour, and preparing the patient and the surgical team for the more extensive procedure generally required for a high grade malignancy.
https://ift.tt/2qDPL82
Newborn Hearing Screening: Time to Act!
Abstract
The present study was carried out with the aim of assessing the outcomes of otoacoustic hearing screening in newborns coupled with the three stage protocol. It was a hospital based observational study which was conducted over a time period of twelve months at a tertiary care institute to screen 2000 live neonates for congenital hearing impairment using OAE, followed up by tympanometry and BERA, if required. 2000 neonates were screened for hearing impairment. 406 were in high risk group and the rest in non-high risk group. Seven neonates had absent V wave on BERA. Five of them were high risk babies and the rest two were non-high risk ones. In order to ensure that early detection and effective intervention are possible for all neonates with hearing impairment, UNHS should be performed. Three stage UNHS protocol using OAE and BERA showed that the implementation of UNHS for congenital childhood hearing loss for all neonates would be beneficial.
https://ift.tt/2H4bErX
Invasive Listeriosis of Intracardiac Device
Introduction. Listeria monocytogenes is a food-borne pathogen which can cause invasive infection in immunocompromised adults. Listeria has been known to cause infections during pregnancy and in older adults. Listeria endocarditis is a rare condition. A case of listeria-related intracardiac device infection is reported below. Case Report. A 74-year-old male with a past medical history of coronary artery disease, congestive cardiac failure, permanent atrial fibrillation status after nodal ablation, and placement of a biventricular pacemaker presented to the hospital with complaints of generalized fatigue. He was found to have listeria bacteremia, and transthoracic echocardiogram (TTE) showed pacemaker lead vegetation. The patient was treated with 6 weeks of vancomycin followed by oral suppression with amoxicillin. Discussion. Listeria can affect native valves, prosthetic valves, or nonvalvular intracardiac devices. The mean age of prosthetic valve endocarditis has been reported to be 67 years with male-to-female ratio 1.7 : 1 and mitral-to-aortic valve ratio 1.3 : 1. There have been case reports of listeria prosthetic valve endocarditis; however, there is paucity of literature on listeria-related pacemaker lead infection. Treatment is mostly a combination of penicillin and aminoglycosides for 4–6 weeks. Surgical removal of the infected device is preferred. Invasive listeriosis is a rare but fatal entity which should be identified and treated promptly to ensure a good outcome.
https://ift.tt/2ETj5fM
40 Millionen Euro für die medizinische Forschung
Die Hochschulmedizin in Deutschland soll für junge Wissenschaftler attraktiver werden. Den Startschuss dazu gibt jetzt nicht etwa die öffentliche Hand, sondern eine private Stiftung.
https://ift.tt/2JRRO18
Rezepte gestohlen? Schadensersatz droht!
Werden Rezepte und Stempel aus der Praxis gestohlen, sind Schadensersatzansprüche gegen Ärzte durchaus möglich — vorausgesetzt, sie haben ihre Sorgfaltspflicht verletzt.
https://ift.tt/2ES5ENc
Bei Krampfadern ist das Thromboserisiko erhöht
Varizen sollten, auch wenn sie keine Beschwerden verursachen, nicht nur als kosmetisches Problem angesehen werden: Sie sind mit einer erhöhten Rate von tiefen Venenthrombosen verknüpft.
https://ift.tt/2JRRK1o
Tagung Dermatologische Praxis 2018
Der Einsatz von Lasern in der ästhetischen Medizin ist vielfältig, wie jüngst auch wieder bei der Tagung Dermatologische Praxis 2018 gezeigt wurde. Die Weiterentwicklung der Methoden und die Kombination mit anderen Behandlungsformen verbessern die Ergebnisse zunehmend.
https://ift.tt/2JRRn70
Vitamin D schützt die Haut vor dem Altern, oder?
Die Literatur liefert widersprüchliche Ergebnisse zum Thema Vitamin D und Hautalterung. In-vitro-Experimente zeigen, dass Vitamin D die Haut vor dem Alter schützt, Populationsstudien demonstrieren das Gegenteil. Was stimmt?
https://ift.tt/2JQRwqZ
Gynäkomastie — Ursachen und mögliche Behandlungen
Die Gynäkomastie ist eine relativ verbreitete Veränderung der männlichen Brustdrüse. Vor einer Therapie sollten mögliche ursächliche Erkrankungen überprüft werden. Bei einer mäßiggradigen Ausprägung ist eine Volumenreduktion ohne Straffung der Umgebungshaut ausreichend, während bei ausgeprägteren Formen eine zusätzliche Straffung des überschüssigen Hautmantels erforderlich ist.
https://ift.tt/2vntFMF
To Study the Role of FNAC in Pre-operative Diagnostic Work Up and Management in Parotid Tumours
Abstract
Parotid gland is an important major salivary gland connected to the oral cavity. Salivary gland tumours are infrequent around less than 3% of head and neck tumours. Parotid gland is the most common site for the occurrence of salivary tumors. They are heterogeneous group of neoplasm characterized by the varying histological features and clinical behaviour. In our study we have examined the role of FNAC for preoperative diagnostic and management. We have concluded that Fine needle aspiration cytology is advocated routinely to know the type and nature of the tumour as an important pre-operatively diagnostic work up. It helps in preoperative identification of type of tumour neoplastic or benign, preoperative counselling of patient, planning of management of tumour, and preparing the patient and the surgical team for the more extensive procedure generally required for a high grade malignancy.
https://ift.tt/2qDPL82
Newborn Hearing Screening: Time to Act!
Abstract
The present study was carried out with the aim of assessing the outcomes of otoacoustic hearing screening in newborns coupled with the three stage protocol. It was a hospital based observational study which was conducted over a time period of twelve months at a tertiary care institute to screen 2000 live neonates for congenital hearing impairment using OAE, followed up by tympanometry and BERA, if required. 2000 neonates were screened for hearing impairment. 406 were in high risk group and the rest in non-high risk group. Seven neonates had absent V wave on BERA. Five of them were high risk babies and the rest two were non-high risk ones. In order to ensure that early detection and effective intervention are possible for all neonates with hearing impairment, UNHS should be performed. Three stage UNHS protocol using OAE and BERA showed that the implementation of UNHS for congenital childhood hearing loss for all neonates would be beneficial.
https://ift.tt/2H4bErX
Functional expansion pharyngoplasty: Technical update by unidirectional barbed sutures
Clinical Otolaryngology, EarlyView.
https://ift.tt/2J2gF0C
Epidemiological features of cancers of the oral cavity, oropharynx, hypopharynx and larynx cancer in Réunion Island
Publication date: Available online 16 April 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A. Delagranda, G. Leterme, E. Chirpaz, C. Ferdynus, C. Fernandez, F. Rubin
IntroductionThis study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature.Material and methodA retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island. Demographic characteristics and data on alcohol consumption, smoking habits and HPV infection were analyzed. Standardized incidences were calculated for the worldwide population for both genders.ResultsSex ratio was 7.7 and mean age was 60 years. Cancer consisted of squamous cell carcinoma in 99.1% of patients. Three hundred and forty over 375 patients (81.25%) showed alcohol abuse; 309/359 (86.1%) were smokers; 31/184 (16%) had HPV infection. On the International Agency for Research on Cancer (IARC) anatomic classification, the incidence of "other pharynx" locations was 9.3/100,000 for men and 0.7/100,000 for women, and incidence of "larynx" locations was 6.4/100,000 for men and 0.4/100,000 for women.ConclusionRéunion Island features some particularities in terms of incidence: women are less than half as likely as in Metropolitan France to develop any type of cancer, whereas incidence in males is among highest in France. The presentation of results in cancer registries could be improved in line with everyday practice in head and neck surgery.
https://ift.tt/2HFJmRA
Molecular characterization of qnrVC and their novel alleles in Vibrio spp. isolated from food products in China [PublishAheadOfPrint]
This study reported the prevalence of qnrVC genes in 74 ciprofloxacin-resistant Vibrio spp. isolates. Two novel functional qnrVC alleles, qnrVC8 and qnrVC9, sharing 98% and 99% nucleotide similarity with qnrVC6 and qnrVC7 respectively, were identified. Our findings suggested that carriage of qnrVC alleles, together with target mutations in gyrA and parC genes, may contribute to development of fluoroquinolone resistance in Vibrio species, posing serious threat to public health.
https://ift.tt/2ETh6bk
Characterization of extensively- or pandrug-resistant ST147 and ST101 OXA-48-producing Klebsiella pneumoniae isolates causing bloodstream infections in ICU patients [PublishAheadOfPrint]
Carbapenem-resistant Klebsiella pneumoniae cause important healthcare-associated infections worldwide. An outbreak of ST11 OXA-48-producing K. pneumoniae isolates (OXA-48-Kp) occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp recovered from 19 ICU patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. β-lactamase genes were detected by PCR. All isolates were typed by PFGE/MLST and 10 representative isolates by next generation sequencing (NGS). Of the 19 study patients, nine had previous hospitalizations and 10 carried OXA-48-Kp prior to BSI isolations; median time from ICU admission to BSI was 29 days. Four OXA-48-Kp belonged to PFGE profile A (ST147) and were pandrug-resistant (PDR), while 15 isolates exhibited PFGE profile B (ST101) and were extensively drug-resistant. NGS resistome analysis detected genes justifying resistances, except for tigecycline and fosfomycin. Insertional inactivation of mgrB (distinct per clone) conferred colistin resistance in all 19 isolates. NGS SNPs analysis validated the clonal relatedness of the ST147 and ST101 strains and revealed possible presence of two index ST147 strains and microevolution of ST101 strains. Distinct, but highly related, IncL OXA-48-encoding plasmid lineages were identified; plasmids of the ST147 strains were identical with that of ST11 OXA-48-Kp causing the 2012 outbreak. In conclusion, biclonal circulation of OXA-48-Kp and, alarmingly, emergence of a PDR clone are reported. These observations, along with the challenging phenotypic detection of OXA-48 producers and the high reported transmissibility of blaOXA-48, necessitate intensive efforts to prevent their further spread.
https://ift.tt/2JRRiQs
Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus [PublishAheadOfPrint]
Simeprevir is a novel NS3/4A protease inhibitor (PI) of hepatitis C virus (HCV). The baseline polymorphism NS3-Q80K is frequently observed in genotype (gt) 1a HCV and often associated with treatment failure in simeprevir-containing regimens. We aimed to elucidate mechanisms of treatment failure due to NS3-Q80K. We included a Q80R mutation in our study and generated a series of Huh-7.5 cells, each of which harbored either wild-type gt 1a H77S.3 or one of the variants, Q80K or Q80R. The cells were cultured with increasing concentrations of simeprevir, and NS3 domain sequences were determined. The mutations identified by sequence analyses were subsequently introduced into H77S.3. The sensitivity of each mutant to NS3/4A PIs simeprevir, asunaprevir, grazoprevir, and paritaprevir was analyzed. We introduced the mutations into gt 1b N.2 and compared the sensitivity to simeprevir with that in gt 1a H77S.3. While simeprevir treatment selected mutations at residue D168, such as D168A/V in the wild-type virus, an additional mutation at residue R155, R155K, was selected in Q80K/R variants at simeprevir concentrations lower than 2.5 μM. Sensitivity analyses showed that simeprevir concentrations of less than 1 μM significantly boosted the replication of Q80K/R+R155K variants. Interestingly, this boost was not observed with the other NS3/4A PIs, and not in Q80R+R155Q/G/T/W variants or gt 1b. The boosted replication of Q80K+R155K by simeprevir could be related to treatment failure in simeprevir-containing antiviral treatments in gt 1a HCV-infected patients with the NS3-Q80K polymorphism. This result provides a new insight into how resistance-associated variants can cause treatment failure.
https://ift.tt/2vjR3uq
The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension [PublishAheadOfPrint]
The metabolism of posaconazole is mediated mainly by uridine 5' -diphospho-glucuronosyltransferase (UGT) enzymes, especially the UGT1A4. The aim of this study was to investigate the effects of genetic polymorphisms on the posaconazole plasma concentration (PPC). This prospective study was conducted from September 2014 to August 2016. We enrolled patients with acute myeloid leukemia or myelodysplastic syndrome treated with posaconazole oral suspension (200 mg) three times daily for fungal prophylaxis. The multi-drug resistance gene 1 3435C>T and 2677G>T/A variations, and UGT1A4*3 were examined by direct sequencing of DNA from peripheral whole blood samples. We defined poor absorbers as those with PPCs <200 ng/mL and the optimal PPC as ≥700 ng/mL on day 8. The associations between genetic polymorphisms and the PPC were evaluated using multivariate logistic regression analysis including clinical variables. In the study period, 132 patients were enrolled. Six patients (4.5%) were defined as poor absorbers and 49 patients (37.1%) did not reach the optimal PPC on day 8. In multivariate analysis, the independent risk factors for a poor absorber were at least one UGT1A4*3 allele (adjusted odds ratio [lsqb]aOR[rsqb], 18.81; 95% confidence interval [lsqb]CI[rsqb], 1.09-324.44; p = 0.043) and poor oral food intake (aOR per -100 kcal, 1.44; 95% CI, 1.04-1.99; p = 0.029). There was no statistically significant association between the genetic polymorphisms and reaching the optimal PPC on day 8. The UGT1A4*3 polymorphism is an independent risk factor for being a poor absorber of posaconazole oral suspension in patients with hematologic malignancies.
https://ift.tt/2JQF9Ly
Characterising blood stage antimalarial drug minimum inhibitory concentrations in vivo using reinfection patterns [PublishAheadOfPrint]
The minimum inhibitory concentration (MIC) is an essential quantitative measure of the asexual blood stage effect of an antimalarial drug. In areas of high malaria transmission, and thus frequent individual infection, patients who are treated with slowly eliminated antimalarials become reinfected as drug concentrations decline. In the frequent relapse forms of P. vivax and in P. ovale malaria, recurrent infection occurs from relapses which begin to emerge from the liver approximately two weeks after the primary illness. An important determinant of the interval from starting treatment of a symptomatic infection to the patency of these recurrent infections is the in vivo concentration-response relationship and thus the in vivo MIC. Using mechanistic knowledge of parasite asexual replication and the pharmacokinetic and pharmacodynamic properties of the antimalarial drugs, a generative statistical model was derived which relates the concentration-response relationship to time of reinfection patency. This model was used to estimate the in vivo MIC of chloroquine in the treatment of Plasmodium vivax malaria.
https://ift.tt/2vjesMD
Spread of clonally related Escherichia coli harboring an IncA/C1 plasmid encoding IMP-8 and its recruitment into an unrelated MCR-1-containing isolate [PublishAheadOfPrint]
Ten IMP-8-producing Escherichia coli isolates were recovered from the surveillance cultures of a neonatal intensive care unit, of which eight were clonally related. A 168.2-kb-blaIMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13. This plasmid was detected in all isolates, even in those no clonally related. One unrelated isolate was also resistant to colistin and positive for mcr-1. This marker was located in a 62.7-kb-IncI2 plasmid, which was also fully sequenced.
https://ift.tt/2JT7IYK
HC2091 kills Mycobacterium tuberculosis by targeting the MmpL3 mycolic acid transporter [PublishAheadOfPrint]
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), is a deadly disease that requires a long course of treatment. The emergence of drug resistant strains has driven efforts to discover new small molecules that can kill the bacterium. Here we report characterizations of the compound HC2091 that kills Mtb in a time- and dose-dependent manner in vitro, as well as inhibiting Mtb growth in macrophages. Whole genome sequencing of spontaneous resistant mutants to HC2091 identified single nucleotide variants in the mmpL3 mycolic acid transporter gene. HC2091 resistant mutants do not exhibit cross-resistance with the well-characterized MmpL3 inhibitor SQ109, suggesting a distinct mechanism of interaction with MmpL3. Additionally, HC2091 does not modulate bacterial membrane potential or kill non-replicating Mtb, thus acting differently from other known MmpL3 inhibitors. RNA-seq transcriptional profiling and lipid profiling of Mtb treated with HC2091 or SQ109 show that both compounds target a similar pathway. HC2091 has a dissimilar chemical structure from previously described MmpL3 inhibitors, supporting that HC2091 is a new class of MmpL3 inhibitor.
https://ift.tt/2vlhEqN
Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in the Acute Pig Model of Cryptosporidium hominis [PublishAheadOfPrint]
Recent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute diarrhea caused by Cryptosporidium hominis, the species responsible for most human cases. Five day-treatment with BKI 1369 reduced signs of disease early during treatment compared with untreated animals. Piglets treated with BKI 1369 exhibited a significant reduction of oocyst excretion, mucosal colonization by C. hominis, and mucosal lesions, which resulted in considerable symptomatic improvement. BKI 1369 reduced parasite burden and disease severity in the gnotobiotic pig model. Together, these data suggest that the BKI-mediated therapeutic could potentially be an effective treatment against cryptosporidiosis.
https://ift.tt/2JRRhvS
Moxifloxacin replacement in contemporary tuberculosis drug regimens is ineffective against persistent Mycobacterium tuberculosis: Novel insights from the Cornell mouse model [PublishAheadOfPrint]
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a leading killer worldwide, and disease control is hampered by ineffective control of persistent infections. Substitution of moxifloxacin for isoniazid or ethambutol in standard TB regimens reduces treatment duration and relapse rates in animal studies and four-month regimens were not non-inferior in clinical trials. Resuscitation promoting factor (RPF) dependent bacilli have recently been implicated in M. tuberculosis persistence. We aimed to investigate the therapeutic effects of moxifloxacin substitution in the standard drug regimen for eradicating colony forming count (CFU) positive and RPF-dependent persistent M. tuberculosis using the Cornell murine model. M. tuberculosis infected mice were treated with regimens in which either isoniazid or ethambutol were replaced by moxifloxacin to the standard regimen. The efficacy of the regimens was compared to the standard regimen for bacterial CFU count elimination and removal of persistent tubercle bacilli evaluated using culture filtrate (CF) derived from M. tuberculosis strain H37Rv. We also measured disease relapse rates. Moxifloxacin-isoniazid substituted regimen achieved total organ CFU count clearance at 11 weeks post-treatment, faster than standard regimen (14 weeks), and with a 34% lower relapse rate. Moxifloxacin-ethambutol substituted regimen was similar to standard regimens in these regards. Importantly, neither moxifloxacin-substituted regimens nor the standard regimen could remove CF-dependent persistent bacilli. Evaluation of CF-dependent persistent M. tuberculosis requires confirmation in human studies, and has implications in future drug design, testing and clinical applications.
https://ift.tt/2vkGTJV
Treating Anthrax-Induced Meningitis in Rabbits [PublishAheadOfPrint]
Treatment of Anthrax is challenging, especially during the advanced stages of the disease. Recently the CDC updated its recommendations for post-exposure prophylaxis and treatment of exposed populations (pre and post symptoms onset). These recommendations distinguished, for the first time, between the systemic disease with and without meningitis, a common and serious complication of anthrax. The CDC considers all systemic patients as meningeal unless positively proven otherwise. The treatment of patients suffering from systemic Anthrax with suspected or confirmed meningitis includes the combination of three antibiotics -- a fluoroquinolone (Levofloxacin or Ciprofloxacin), a β-lactam (Meropenem or Imipenem) and a protein-synthesis inhibitor (Linezolid or Clindamycin). In addition, treatment with an antitoxin (αPA antibodies) and Dexamethasone should also be applied. Since the efficacy of most of these treatments was not demonstrated, especially in meningeal animal models, we developed an Anthrax-meningitis model in rabbits and tested several of these recommendations. We demonstrate that in this model, Ciprofloxacin, Linezolid and Meropenem are ineffective as single treatments while Clindamycin is highly effective. Furthermore, combined treatments of Ciprofloxacin and Linezolid, or Ciprofloxacin and Dexamethasone failed in treating meningeal rabbits. We demonstrate that Dexamethasone actually hinders the blood brain barrier penetration of antibiotics, reducing the effectiveness of antibiotic treatment of Anthrax-meningitis in the rabbit model.
https://ift.tt/2JSOLWs
Antimicrobial and antibiofilm efficacy of graphene oxide against chronic wound microorganisms [PublishAheadOfPrint]
Chronic wounds represent an increasing problem worldwide. Graphene oxide (GO) has been reported to exhibit strong antibacterial activity towards both Gram-positive and Gram-negative bacteria. The aim of this work was to investigate the in vitro antimicrobial and antibiofilm efficacy of GO against wound pathogens. Staphylococcus aureus PECHA 10, Pseudomonas aeruginosa PECHA 4 and Candida albicans X3 clinical isolates were incubated with 50 mg/L of GO for 2 and 24 h to evaluate the antimicrobial effect. Optical and Atomic force microscopy images were performed to visualize the GO effect on microbial cells. Moreover, the antibiofilm effect of GO was tested on biofilms both in formation and mature. When compared to the respective time controls, GO significantly reduced the S. aureus growth both at 2 and 24 h in a time dependent way, and displayed a bacteriostatic effect in respect to the GO t=0; an immediate (after 2 h) slowdown of bacterial growth was detected for P. aeruginosa whereas a tardive effect (after 24 h) was recorded for C. albicans. Atomic force microscopy images showed the complete wrapping of S. aureus and C. albicans with GO sheets that explains its antimicrobial activity. Moreover, significant inhibition of biofilm formation and a reduction of mature biofilm were recorded for each detected microorganism. The antibacterial and antibiofilm properties of GO against chronic wound microrganisms make it an interesting candidate to incorporate into wound bandages to treat and/or prevent microbial infections.
https://ift.tt/2EPhUxX
In vitro antimicrobial susceptibility of clinical isolates of Borrelia miyamotoi. [PublishAheadOfPrint]
Objectives: Borrelia miyamotoi is an emerging relapsing fever (RF) Borrelia species that is described to cause human disease in regions where Lyme borreliosis is endemic. We have recently shown that B. miyamotoi tick isolates are resistant to amoxicillin in vitro, however, clinical isolates have not been studied. Therefore, our aim was to show antimicrobial susceptibility of recently obtained clinical isolates of B. miyamotoi.
Methods: A dilution series of various antibiotics was made in MKP-F media. Susceptibility of different clinical B. miyamotoi, B. miyamotoi tick, RF Borrelia and B. burgdorferi sensu lato isolates were tested by measuring MICs through colorimetric change and by counting motile spirochetes by darkfield microscopy after 72 hours of incubation.
Results: The MIC ranges of the six tested clinical B. miyamotoi isolates to ceftriaxone and azithromycin were 0,03-0,06 mg/L and 0,0016-0,0032 mg/L, respectively. This is similar to MICs from RF Borrelia- and B. miyamotoi tick isolates. All tested RF Borrelia were susceptible to doxycycline (microscopic MIC range 0,0625-0,25 mg/L). In contrast to the MIC of the tested B. burgdorferi sl strains and in line with our previous findings, the MICs for amoxicillin (range 8-32mg/L) of all RF Borrelia -- including B. miyamotoi clinical isolates -- were above the clinical breakpoint for resistance (≤4 mg/L).
Conclusions: Clinical isolates of B. miyamotoi are highly susceptible to doxycycline, azithromycin and ceftriaxone in vitro. Interestingly, as earlier described for tick isolates, amoxicillin shows poor in vitro activity against clinical B. miyamotoi isolates.
https://ift.tt/2JN0yoZ
Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia [PublishAheadOfPrint]
APH(2")-Ia aminoglycoside resistance enzyme forms the C-terminal domain of the bifunctional AAC(6')-Ie/APH(2")-Ia enzyme and confers high-level resistance to natural 4,6-disubstituted aminoglycosides. In addition, reports have suggested that the enzyme can phosphorylate 4,5-disubstituted compounds and aminoglycosides with substitutions at the N1-position. Previously determined structures of the enzyme with aminoglycosides bound have not indicated how these non-canonical substrates could bind and be modified by the enzyme. We carried out crystallographic studies to directly observe the interaction of these compounds with the aminoglycoside-binding site and probe the means by which these non-canonical substrates interact with the enzyme. We find that APH(2")-Ia maintains a preferred mode of binding aminoglycosides using the conserved neamine rings when possible, with flexibility that allows it to accommodate additional rings. However, if this binding mode is made impossible because of additional substitutions to the standard 4,5- or 4,6-disubstituted aminoglycoside architecture as in lividomycin A or the N1-substituted aminoglycosides, it is still possible for these aminoglycosides to bind to the antibiotic-binding site, using alternate binding modes, explaining the low rates of non-canonical phosphorylation activities seen in enzyme assays. Furthermore, structural studies of a clinically-observed arbekacin-resistant mutant of APH(2")-Ia reveals an altered aminoglycoside binding site that can stabilize an alternative binding mode for N1-substituted aminoglycosides. This mutation could alter and expand the aminoglycoside resistance spectrum of the wildtype enzyme in response to newly developed aminoglycosides.
https://ift.tt/2vje4gS
Amikacin Inhalation as Salvage Therapy for Refractory Nontuberculous Mycobacterial Lung Disease [PublishAheadOfPrint]
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%). Macrolide resistance and baseline AMK resistance were identified in 63 (82%) patients and five (6%) patients, respectively. Twelve months after AMK inhalation therapy, 49% of patients had symptomatic improvement, whereas 42% had radiologic improvement. Sputum negative culture conversion occurred in 14 (18%) patients, and the culture conversion rate was higher in patients infected with macrolide-susceptible isolates (7/14, 50%) than with macrolide-resistant isolates (7/63, 11%, P = 0.003). Significant decreases in sputum semiquantitative culture positivity occurred after AMK inhalation therapy (P < 0.001). On multivariate analysis, sputum culture conversion was associated with mixed infections (P = 0.009), a forced expiratory volume in one second of greater than 60% (P = 0.008), and with the absence of macrolide resistance (P = 0.003). Thirty-eight percent of patients experienced adverse effects, with ototoxicity (n = 15) most common. AMK inhalation salvage therapy may improve treatment responses in some patients with refractory NTM-LD. However, considering the common adverse effects, further evaluation of optimal dosage and intervals for AMK inhalation is needed.
https://ift.tt/2JN0tlb
Refractory hypokalemia from syndrome of apparent mineralocorticoid excess on low-dose posaconazole [PublishAheadOfPrint]
A 67-year-old woman with acute myeloid leukemia experienced refractory hypokalemia while taking low-dose posaconazole....
https://ift.tt/2vkMAaP
Triclosan is an aminoglycoside adjuvant for the eradication of Pseudomonas aeruginosa biofilms [PublishAheadOfPrint]
One of the most important clinical obstacles in cystic fibrosis (CF) is antibiotic treatment failure due to biofilms produced by Pseudomonas aeruginosa. The ability of this pathogen to survive eradication by tobramycin and pathoadapt into a hyper-biofilm state leading to chronic infections is key to its success. Retrospective studies have demonstrated that preventing this pathoadaptation by improving eradication is essential to extend the lives of CF patients. To identify adjuvants that enhance tobramycin eradication of P. aeruginosa, we performed a high-throughput screen of 6,080 compounds from four drug repurposing libraries. We identified that the Food and Drug Administration (FDA) approved compound, triclosan, combined with tobramycin resulted in a 100-fold reduction of viable cells within biofilms at six hours, but neither compound alone had significant antimicrobial activity against biofilms. This synergistic treatment significantly accelerated killing of biofilms compared to tobramycin treatment alone, and the combination was effective against 6/7 CF clinical isolates compared to tobramycin treatment alone including a tobramycin resistant strain. Further, triclosan and tobramycin killed persister cells, causing a 100-fold reduction by 8-hrs and complete eradication by 24-hrs. Triclosan also enhances tobramycin killing of multiple Burkholderia cenocepacia and Staphylococcus aureus clinical isolates grown as biofilms. Additionally, triclosan synergized with other aminoglycosides such as gentamicin or streptomycin. Triclosan is a well-tolerated aminoglycoside adjuvant shown to be safe for human use that could improve treatment of biofilm-based infections.
https://ift.tt/2JN0p4V
Genetic diversity among S. aureus isolates showing oxacillin and/or cefoxitin resistance not linked to the presence of mec genes [PublishAheadOfPrint]
Methicillin-resistant Staphylococcus aureus isolates lacking mec-genes (n=32) collected from Belgian hospitals were characterized for their β-lactamase production and the presence of mutations in pbp-genes, the pbp4-promotor and genes (gdpP, yjbH) involved in PBP4-overproduction. Twelve isolates were β-lactamase hyperproducers (BHP), while 12 non-BHPs isolates may produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations at pbp genes. Few isolates showed also mutations at the pbp4-promoter.
https://ift.tt/2vq9zBw
Accelerating early anti-tuberculosis drug discovery by creating mycobacterial indicator strains that predict mode of action [PublishAheadOfPrint]
Due to the rise of drug resistant forms of tuberculosis there is an urgent need for novel antibiotics to effectively combat these cases and shorten treatment regimens. Recently, drug screens using whole cell analyses have been shown to be successful. However, current high-throughput screens focus mostly on stricto sensu life-death screening that give little qualitative information. In doing so, promising compound scaffolds or non-optimized compounds that fail to reach inhibitory concentrations are missed. To accelerate early TB drug discovery, we performed RNA sequencing on Mycobacterium tuberculosis and Mycobacterium marinum to map the stress responses that follow upon exposure to sub-inhibitory concentrations of antibiotics with known targets: ciprofloxacin, ethambutol, isoniazid, streptomycin and rifampicin. The resulting dataset comprises the first overview of transcriptional stress responses of mycobacteria to different antibiotics. We show that antibiotics can be distinguished based on their specific transcriptional stress fingerprint. Notably, this fingerprint was more distinctive in M. marinum. We decided to use this to our advantage and continue with this model organism. A selection of diverse antibiotic stress genes was used to construct stress reporters. In total, three functional reporters were constructed to respond to DNA damage, cell wall damage and ribosomal inhibition. Subsequently, these reporter strains were used to screen a small anti-TB compound library to predict the mode of action. In doing so, we could identify the putative mode of action for three novel compounds, which confirms our approach.
https://ift.tt/2JQusc5
Modeling and Simulation of Pretomanid Pharmacokinetics in Pulmonary Tuberculosis Patients [PublishAheadOfPrint]
Pretomanid is a nitroimidazole antibiotic in late phase clinical testing as a component of several novel antituberculosis (anti-TB) regimens. A population pharmacokinetic model for pretomanid was constructed using a Bayesian analysis of data from two phase 2 studies, PA-824-CL-007 and PA-824-CL-010, conducted with newly diagnosed adult (median age 27 years) pulmonary TB patients in Cape Town, South Africa. Combined, these studies included 63 males and 59 females administered once daily oral pretomanid doses of 50, 100, 150, 200, 600, 1000, or 1200 mg for 14 days. The observed pretomanid concentration-time profiles for all tested doses were described by a one-compartment model with first-order absorption and elimination, and a sigmoidal bioavailability dependent on dose, time, and predose fed state. Allometric scaling with body weight (normalized to 70 kg) was used for volume of distribution and clearance, with scaling exponents of 1 and 3/4, respectively. The posterior population geometric means for clearance and volume of distribution allometric constants were 4.8±0.2 L/h and 130±5 L, respectively, and 450±50 mg for the half-maximum effect dose for reduction of bioavailability. Interindividual variability, described by percent coefficient of variation, was 32±3% for clearance, 17±4% for volume of distribution, and 74±9% for half-maximum effect dose. This model provides a dose-exposure relationship for pretomanid in adult TB patients, with potential applications to dose selection in individuals and to further clinical testing of novel pretomanid-containing anti-TB regimens.
https://ift.tt/2EPhzLH
SOURCE OF THE FITNESS DEFECT IN RIFAMYCIN-RESISTANT M. TUBERCULOSIS RNA POLYMERASE AND THE MECHANISM OF COMPENSATION BY MUTATIONS IN THE {beta}'-SUBUNIT [PublishAheadOfPrint]
Mycobacterium tuberculosis (MTB) is a critical threat to human health due to the increased prevalence of rifampin resistance (RMPR). Fitness defects have been observed in RMPR mutants having amino acid substitutions in the β-subunit of RNA polymerase (RNAP). In clinical isolates, this fitness defect can be ameliorated by the presence of secondary mutations in the double-psi β-barrel (DPBB) domain of the β'-subunit of RNAP. To identify factors contributing to the fitness defects observed in vivo, several in vitro RNA transcription assays were utilized to probe initiation, elongation, termination, and 3' -RNA hydrolysis with the wild-type and RMPR MTB RNAPs. We found that the less prevalent RMPR mutants exhibit significantly poorer termination efficiencies relative to wild-type, an important factor for proper gene expression. We also found that several mechanistic aspects of transcription of the RMPR mutant RNAPs are impacted relative to wild-type. For the clinically most prevalent, βS450L mutant, these defects are mitigated by the presence of secondary/compensatory mutations in the DPBB domain of the β'-subunit.
https://ift.tt/2JN0buB
Association between nasopharyngeal carcinoma and risk of optic neuropathy: A population‐based cohort study
Head &Neck, EarlyView.
https://ift.tt/2H4jzkV
Analgetikabedarf bei Kindern im Alter zwischen 2 und 12 Jahren nach Tonsillenoperationen
Laryngo-Rhino-Otol
DOI: 10.1055/a-0596-7675
Hintergrund Mandeloperationen bei Kindern zählen zu den schmerzhaftesten Eingriffen. Altersgerechte Schmerzskalen sind die Kindliche Unbehagens- und Schmerzskala (KUSS), die Faces Pain Scale–Revised (FPS-R) und der kaum bekannte PPPM-D-Fragebogen. Ziel war Evaluation der Analgesie bei durch Eltern angeforderter Nichtopioid-Medikation (NOM) mit Ibuprofen (IBU) und Paracetamol (PCM) nach intrakapsulärer Tonsillektomie (TO) oder extrakapsulärer Tonsillektomie (TE). Als Rescue-Medikation (RM) wurde nach Prüfung der Schmerzskalen Piritramid appliziert. Endpunkte waren Anteil der Patienten (PAT), der die RM benötigte, Menge applizierter NOM, Übereinstimmung der Indikation in verschiedenen Schmerzskalen, Korrelation von Schmerzen mit Prämedikation und Eingriffsdauer. Material/Methoden Postoperativ erfolgten 3 Messungen täglich mit KUSS bei PAT ≤ 4 Jahre bzw. FPS-R ≥ 5 Jahre. Eltern füllten den PPPM-D aus. Bei einem Wert ≥ 4 bei KUSS bzw. FPS-R oder ≥ 6 im PPPM-D wurde die RM indiziert. Ergebnisse 68 PAT wurden in eine Zwischenauswertung eingeschlossen. Durchschnittliche tägliche NOM in den ersten 3 Tagen: nach TE 14,1–16,3 mg/Kg IBU und 4,2–12,4 mg/Kg PCM bzw. nach TO 10,8–14,7 mg/Kg IBU und 5,2–8,8 mg/Kg PCM. Bei 212 Visiten wurde die RM indiziert, davon 121 Mal nur durch den PPPM-D. Nach Ausschluss eventuell falsch-positiver Indikationen benötigten 67 % der PAT nach TE und 48 % der PAT nach TO mindestens einmal die RM. Die Studie wurde wegen des hohen RM-Bedarfs abgebrochen. Schlussfolgerungen Der Bedarf an NOM wurde unterschätzt. Der PPPM-D kombiniert mit etablierten Skalen kann die postoperative Schmerztherapie verbessern.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2vq5e16
Issue Information ‐ TOC
https://ift.tt/2vmdZZS
Seasonal variation in prey composition and digestion in small mammal predator assemblages
International Journal of Osteoarchaeology, EarlyView.
https://ift.tt/2JQRjEv
Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology
Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.
https://ift.tt/2qCVhHO
Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen.
Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations.
https://ift.tt/2H839fO
Functional and anatomical results of inside out approach for cholesteatoma surgery
To study the efficacy of inside-out approach in completely eradicating the cholesteatoma from middle ear and mastoid, preservation of hearing & and quality of life post mastoidectomy with regards to recurrent discharge, wax, granulations.
https://ift.tt/2IX3Gxy
Surgeon-performed ultrasound for the assessment of parotid masses
Studies on parotid gland ultrasound assessments performed specifically by surgeons are seldom reported.
https://ift.tt/2HsKwlW
Management of laryngeal cleft in mechanically ventilated children with severe comorbidities
Laryngeal clefts are rare congenital malformations of the posterior part of the larynx. The severities are correlated with the downward extension of the cleft and can involve numerous clinical symptoms including dysphagia and respiratory distress. As significant comorbidities may be present, individual treatments depend on the child's general condition and type of cleft involved. Herein, we describe two cases of children with laryngeal clefts and severe comorbidities requiring mechanical ventilation.
https://ift.tt/2qBgHFt
Extensive nevus comedonicus, complicated with recurrent abscesses, successfully treated with surgical resurfacing
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):33-37
Nevus comedonicus is a rare epidermal abnormality of the pilosebaceous unit, which is congenital in most patients but may also appear early in childhood. It may be localized or have an extensive involvement, the latter showing a unilateral predominance with only a few cases presenting bilaterally. Extensive nevus comedonicus can be associated with musculoskeletal defects, eye and neurological involvement, which constitutes nevus comedonicus syndrome. Uncomplicated nevus comedonicus can be treated with topical keratolytics, diode, erbium laser, and ultrapulse CO2 laser. Surgical excision can be performed to ensure complete removal and nonrecurrence. This case report refers to a young male patient with extensive nevus comedonicus present over left chest, left axilla, and left upper back without systemic involvement, treated with staged surgical excision and resurfacing.
https://ift.tt/2ESL538
Xanthelasma: An update on treatment modalities
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):1-6
Xanthelasmas are localized accumulation of lipid deposits on the eyelids. Lesions are typically asymptomatic and treatment is often sought for cosmetic purposes. Unfortunately, there is paucity of strong evidence in the literature for the effective treatment of normolipidemic xanthelasmas. A literature search using the term "xanthelasma" was carried out in PubMed and Medline databases. Only articles related to treatment were considered and analyzed for their data. Commonly cited treatments include topical trichloroacetic acid, liquid nitrogen cryotherapy, and various lasers including carbon dioxide, Er:YAG, Q-switched Nd:YAG, and pulse dye laser. However, traditional surgical excision has also been used. This article reviews these currently accepted modalities of treatment.
https://ift.tt/2qCca6e
Piercing ear keloid: Excision using loupe magnification and topical liquid silicone gel as adjuvant
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):7-12
Background: Keloid is an abnormal growth of scar at the site of skin injury, which usually does not regress. It proliferates beyond the original scar. The ear keloid usually develops after piercing injury to wear ornaments. A patient usually asks for removal of keloid, as it is aesthetically unpleasant. Patient may sometimes complain of itching and pain. Aim: The study was conducted to analyze results following excision of keloid with its tract and topical silicone gel as the postsurgical adjuvant. Materials and Methods: Ear keloids measuring less than 0.5cm or more than 5cm in maximum dimension were excluded from the study. Nonpiercing causes such as burns, trauma, and recurrent keloid were excluded from the study. The study was carried out on 22 patients who had keloid because of piercing injury, including 4 cases with both ear keloids. Of 26 ear keloids, 19 had the tract or connecting tissue. The lesion was excised under anesthesia using magnification. For all the operated cases, topical liquid silicone gel was used as postsurgical adjuvant therapy. The method of application of topical silicone gel was taught to each patient and was considered significant. Result: The magnification helped in identification of tract in 73% of the cases in this study. Twenty patients had successfully responded to proposed treatment, and two patients developed recurrence while using topical silicone gel as the adjuvant. These two patients were managed with conventional triamcinolone injection. Conclusion: The topical silicone gel as postsurgical adjuvant therapy avoided the use of painful postsurgical injection or radiotherapy for the 1–3cm primary ear keloids. The advantages of magnification were better clearance of keloid tissue, easier identification of tract and removal of keloid pseudopods, meticulous suturing, and comfortable elevation of a small local flap.
https://ift.tt/2EOKPlL
A practical modification of the fenestrated surgical drape for facial dermatologic surgery
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):40-41
https://ift.tt/2qCc52q
Suction blister epidermal grafting for vitiligo involving angles of lip: Experience of 112 patients
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):13-19
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip. Materials and Methods: This is a prospective study conducted on 112 patients with stable vitiligo involving angles of lip. SBG was carried out in all the patients using the standard procedure. Patients were advised to apply topical psoralen followed by sun exposure (PUVASOL) for 8–12 weeks after operation. The patients were followed up at 3, 6, 12, 18, and 24 months for assessment of pigmentation and overall satisfaction. Results: We found a pigmentation success rate of 83.7%, 84.9%, 85.7%, 78.3%, and 77.8% in the patients who were followed up at 3, 6, 12, 18, and 24 months, respectively. A total of 77.8% of patients who came for follow-up at the end of 24 months were very happy with the treatment. Discussion: Our data show clearance of vitiligo and persistence of pigmentation gained through SBG in 77.8% of cases at the end of 2 years as well as excellent patient satisfaction in the cohort of patients who followed up with us. Conclusion: SBG is an easy and cost-effective way of repigmentation of vitiligo involving angles of lip.
https://ift.tt/2vjuztD
Carpal tunnel syndrome caused by intraneural lipoma of the median nerve and arteriovenous malformation
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):29-32
Carpal tunnel syndrome can be the result of a wide variety of etiologic factors. Compressive causes are rare and tumors causing compression are even rarer. We present a case with a carpal tunnel syndrome caused by an intraneural lipoma and an arteriovenous malformation concomitantly. The lesions were excised, and the patient recovered with full hand function and entire disappearance of acroparesthesia. To our knowledge, this is the first case report of carpal tunnel syndrome caused by an intraneural lipoma and an arteriovenous malformation concomitantly.
https://ift.tt/2HrciiJ
Resurfacing of facial acne scars with a new variable-pulsed Er:YAG laser in Fitzpatrick skin types IV and V
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):20-25
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars. Records of the patients who had undergone four treatment sessions with VSP technology equipped with Er:YAG laser were extracted. Each patient had undergone a minimum of four sessions. Fractional mode at medium laser pulse (SP) and long pulse (LP) was employed for the depressed center of the scars to stimulate neocollagenogenesis. Short laser pulse (MSP) in nonfractionated mode was used for ablating the raised scar border and hypertrophic scars. Goodman and Baron global scarring grading system was used for qualitative and quantitative assessments. Patient's satisfaction to the treatment and observer's assessment of improvement (based on photographs) was graded as poor (<25% improvement), fair (25–50% improvement), good (51–75% improvement), and excellent (>75% improvement). Results: At the end of the four sessions, the number of patients in grade IV postacne scarring reduced from 16 to 2 and that in grade III from 47 to 29. The mean score significantly dropped from 36.94 to 27.5. Subjective assessment revealed that 78 of 80 patients had noticed more than 25% improvement, with 50 of them showing more than 50% improvement at the end of four sessions. Eight patients perceived an excellent response and 42 reported a good response. This is notably higher than the observer's grading, which showed an excellent response in only 2 patients and a good response in 35. Adverse effects were limited to prolonged erythema (two patients), prolonged crusting (one patient), and postinflammatory hyperpigmentation (one patient). Conclusion: Ninety-seven percent of the subjects in our study perceived at least a fair improvement. We also saw a significant change in the objective score with a fall of the mean quantitative score from 36.94 to 27.15. This underscores the new variable-pulsed Er:YAG laser's effectiveness in the treatment of acne scars. It also has the added advantage of lesser adverse events and faster healing.
https://ift.tt/2EQ55DF
Wooden spatula for pain reduction in upper lip laser hair removal
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):38-39
https://ift.tt/2Huiu9M
Scalp defect reconstruction with triple rotation flap: A case report
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):26-28
Scalp surgeries are some of the surgeries frequently performed in dermatosurgery department. These surgical procedures may leave large defects, especially when performed for malignant condition in which wide margin has to be excised. Such large defects are difficult to close primarily when reconstruction with local flap is essential. Here we report a case of epithelioid angiosarcoma of the scalp in a 24-year-old man where excision and reconstruction were performed using triple rotation flap.
https://ift.tt/2viwsqd
Reconstruction of an anterior auricular defect through a tunnelized preauricular transposition flap
Journal of Cutaneous and Aesthetic Surgery 2018 11(1):42-44
https://ift.tt/2Huimai
Comparison of tear proteome in allergic rhinoconjunctivitis patients and controls with respect to pollen season
Allergy, EarlyView.
https://ift.tt/2IWU0De
Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study
Allergy, EarlyView.
https://ift.tt/2HsOJWJ
Helicobacter pylori infection‐induced H3Ser10 phosphorylation in stepwise gastric carcinogenesis and its clinical implications
Helicobacter, EarlyView.
https://ift.tt/2IWHl3a
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply
Helicobacter, EarlyView.
https://ift.tt/2qDJLwE
Sentinel lymph node biopsy in 33 non‐melanoma skin cancers of the head and neck: A twelve‐year experience with long‐term follow‐up
Clinical Otolaryngology, EarlyView.
https://ift.tt/2HFnC8C
Hearing aids in patients with vestibular schwannoma: Interest of the auditory brainstem responses
Clinical Otolaryngology, EarlyView.
https://ift.tt/2H6XN09
Is routine histological tissue sampling during endoscopic dacryocystorhinostomy advantageous? A retrospective analysis of 213 patients
Clinical Otolaryngology, EarlyView.
https://ift.tt/2HHOpkM
Reliable sonographic features for nodal thyroglobulin to diagnose recurrent lymph node metastasis from papillary thyroid carcinoma
Clinical Otolaryngology, EarlyView.
https://ift.tt/2IY2zgS
The price of pain in chronic rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2EOpHff
Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2JOxnlu
Endoscopic and external approaches for orbital decompression: an analysis of trends from a U.S. perspective
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2vj7vLz
Factor analysis of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2JOxbTi
Partial resection of the middle turbinate during endoscopic sinus surgery for chronic rhinosinusitis does not lead to an increased risk of empty nose syndrome: a cohort study of a tertiary practice
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2EOpskl
Successful treatment with interleukin‐17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations
The Journal of Dermatology, EarlyView.
https://ift.tt/2qB0eks
Dacryocystitis mimicking erysipelas due to a giant dacryolith
The Journal of Dermatology, EarlyView.
https://ift.tt/2H3i9LJ
Pediatric case of generalized pustular psoriasis developing acute pancreatitis
The Journal of Dermatology, EarlyView.
https://ift.tt/2qD6IiJ
Linear immunoglobulin A bullous dermatosis limited to oral mucosa associated with ulcerative colitis
The Journal of Dermatology, EarlyView.
https://ift.tt/2H3CCQB
Efficacy and toxicity of ipilimumab used after nivolumab in patients with melanoma
The Journal of Dermatology, EarlyView.
https://ift.tt/2qCdWn6
Alteration of serum thymus and activation‐regulated chemokine level during biologic therapy for psoriasis: Possibility as a marker reflecting favorable response to anti‐interleukin‐17A agents
The Journal of Dermatology, EarlyView.
https://ift.tt/2H4qZch
Pilomatricoma with bullous‐like/anetodermic appearance: Possibly associated with matrix metalloproteinases
The Journal of Dermatology, Volume 45, Issue 4, Page 505-506, April 2018.
https://ift.tt/2qCVCKv
Issue Information
The Journal of Dermatology, Volume 45, Issue 4, Page 509-512, April 2018.
https://ift.tt/2H765sY
Expression of aurora kinase A expression in dermatofibrosarcoma protuberans
The Journal of Dermatology, Volume 45, Issue 4, Page 507-508, April 2018.
https://ift.tt/2qDVHxA
Issue Information
The Journal of Dermatology, Volume 45, Issue 4, Page i, 383-384, April 2018.
https://ift.tt/2H54Ydr
High‐intensity focused ultrasound treatment after cryolipolysis may be used to reduce pain: Two case report
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7iMUM
Exploring the combination of SSKI and topical heparin in a case of erythema nodosum migrans
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBE7KJ
Efficacy and tolerability of a lotion containing triethyl citrate, ethyl linoleate, and GT peptide‐10 in the adjuvant treatment of hidradenitis suppurativa: Real‐life data
Dermatologic Therapy, EarlyView.
https://ift.tt/2H3D4OX
The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment
Dermatologic Therapy, EarlyView.
https://ift.tt/2qBs2oO
Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey
Dermatologic Therapy, EarlyView.
https://ift.tt/2H4pI4Z
Two cases of large cell acanthoma successfully treated with photodynamic therapy
Dermatologic Therapy, EarlyView.
https://ift.tt/2qD58gN
Secukinumab: A positive outcome in a patient with severe psoriasis and HBV‐HCV co‐infection
Dermatologic Therapy, EarlyView.
https://ift.tt/2H7oR3a
Malleostapedotomy in stapes revision surgery: Is an endoscopic approach possible?
The Laryngoscope, EarlyView.
https://ift.tt/2HDs8Vb
Has the management of pediatric mucoepidermoid carcinoma of the parotid gland changed?
The Laryngoscope, EarlyView.
https://ift.tt/2H4Q7vk
Acute sialadenitis associated with 2017–2018 influenza A infection: A case series
The Laryngoscope, EarlyView.
https://ift.tt/2HGduME
Earfold: A New Technique for Correction of the Shape of the Antihelix
The Laryngoscope, EarlyView.
https://ift.tt/2H1ImWT
The influential factors on the morphological changes of upper airway associated with mouth opening
The Laryngoscope, EarlyView.
https://ift.tt/2HEOsNY
Comparison of the seventh and eighth edition american joint committee on cancer oral cavity staging systems
The Laryngoscope, EarlyView.
https://ift.tt/2IZEcQ4
Merkel cell carcinoma in a patient treated with infliximab: Beware of the subcutaneous nodule
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hslnrv
Clinical features and repair options for nonmelanoma skin cancers of the eyebrow
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2vkoltb
A retrospective clinico‐pathological study comparing lichen planus pigmentosus with ashy dermatosis
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2Hsli7b
Maculopapular drug eruption induced by linagliptin
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2ER6HNj
Lymphocytic thrombophilic arteritis complicated by systemic involvement
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2qwSGA7
Cutis tricolor parvimaculata in ring chromosome 15 syndrome: A case report
Pediatric Dermatology, EarlyView.
https://ift.tt/2JOgBD0
Bibbidi bobbidi bald: Two “hairowing” tales of Princess Package hairstyles
Pediatric Dermatology, EarlyView.
https://ift.tt/2vjpcKM
Atypical aluminium patch tests in children with persistent itching postvaccinal nodules
Pediatric Dermatology, EarlyView.
https://ift.tt/2Hp5ySu
Pyoderma gangrenosum in an infant: A case report and review of the literature
Pediatric Dermatology, EarlyView.
https://ift.tt/2vgzE5P
Colchicine may be of therapeutic benefit in prurigo pigmentosa
Pediatric Dermatology, EarlyView.
https://ift.tt/2qB52af
Perinuclear antineutrophil cytoplasmic antibody–positive vasculitis, oligoarthritis, tendinitis, and myositis associated with isotretinoin in a 15‐year‐old boy: Case report and review of literature
Pediatric Dermatology, EarlyView.
https://ift.tt/2EQ6R7K
Chromhidrosis due to exogenous oxidizing heavy metals: Clinical and laboratory findings
Pediatric Dermatology, EarlyView.
https://ift.tt/2HoIFyr
Efficacy and safety of a new 5% minoxidil formulation in male androgenetic alopecia: A randomized, placebo‐controlled, double‐blind, noninferiority study
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H39YPv
Absence of human skin irritation and allergenic potential after repeated patch applications of a lamellar moisturizer
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qEk2U3
Comparative thermographic analysis at pre‐ and postcryolipolysis treatment: Clinical case report
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H4YxHd
Oleic acid enhances keratinocytes differentiation via the upregulation of miR‐203 in human epidermal keratinocytes
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qDa45v
Granulomatous tattoo reactions in permanent makeup of the eyebrows
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2H0NvCC
Use of cosmetic products for treating certain diseases—Know the science
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2qD9TqR
Modified maxillary reconstruction technique for Brown's class III defects by subdividing a rhomboid shaped iliac crest into 2 subunits
Head &Neck, EarlyView.
https://ift.tt/2J0A42a
Efficacy of a clinical pathway for patients with thyroid cancer
Head &Neck, EarlyView.
https://ift.tt/2HqJPd0
Endoscopic Sinonasal Dissection Guide Roy R. Casiano Thieme Medical Publishers, New York, NY, 2012, USD $64.07, 128 pages
Head &Neck, EarlyView.
https://ift.tt/2H2j4YN
MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: Preliminary clinical study
Head &Neck, EarlyView.
https://ift.tt/2HrcuOU
Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival
Head &Neck, EarlyView.
https://ift.tt/2H4KEoi
Management of leaking tracheoesophageal puncture with hyaluronic acid injection
Head &Neck, EarlyView.
https://ift.tt/2Hs0qgd
Tongue cancer epidemiology in Brazil: incidence, morbidity and mortality
Head &Neck, EarlyView.
https://ift.tt/2J1MzKR
In vivo reflectance confocal microscopy combined with the ‘spaghetti technique’ for the identification of surgical margins of lentigo maligna: experience in 70 patients
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H4JysG
Generalized pustular psoriasis: a review and update on treatment
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2HqGydz
Who will treat inflammatory skin diseases in the year 2020?
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H3il9z
Oral psoriasis and SIBO: is there a link?
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2HqGtGN
Circular RNA expression profile analysis of severe acne by RNA‐Seq and bioinformatics
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2H4Jfy2
Google search trends in psoriasis: a pilot evaluation of global population interests
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2qBAAgt
Efficacy of suplatast tosilate in a case of recurrent eosinophilic annular erythema
International Journal of Dermatology, EarlyView.
https://ift.tt/2H1KuSt
Lichen striatus following scarlet fever in a 3‐year‐old female patient
International Journal of Dermatology, EarlyView.
https://ift.tt/2qH0nTJ
Granulocyte colony‐stimulating factor‐producing melanoma treated with the combination of dabrafenib and trametinib
International Journal of Dermatology, EarlyView.
https://ift.tt/2H35wAi
Vedolizumab‐induced acne in inflammatory bowel disease
International Journal of Dermatology, EarlyView.
https://ift.tt/2qH02jV
Concentric targetoid scaly plaques in a patient with severe rheumatoid arthritis
International Journal of Dermatology, EarlyView.
https://ift.tt/2H4U1sl
Heavily pigmented fibroepithelioma of Pinkus mimicking melanoma
International Journal of Dermatology, EarlyView.
https://ift.tt/2qC6isU
Gray‐bluish cutaneous pigmentation and ice‐pick scars induced by vandetanib therapy
International Journal of Dermatology, EarlyView.
https://ift.tt/2H4n5zQ
Transient improvement of skin symptoms in an adult patient with pediatric‐onset cutaneous mastocytosis treated with interferon‐α
International Journal of Dermatology, EarlyView.
https://ift.tt/2qGZnir
A review of bullous pemphigoid associated with PD‐1 and PD‐L1 inhibitors
International Journal of Dermatology, EarlyView.
https://ift.tt/2H30804
Issue Information
International Journal of Dermatology, Volume 57, Issue 5, Page i-iii,503-504, May 2018.
https://ift.tt/2qEieKL
Teaching & Learning Tips 7: small‐group discussion
International Journal of Dermatology, Volume 57, Issue 5, Page 583-586, May 2018.
https://ift.tt/2H3pRW3
A case of pigmentary mosaicism associated with diploid/triploid mixoploidy
International Journal of Dermatology, EarlyView.
https://ift.tt/2qBjRsM
Religious stigmata: a dermato‐psychiatric approach and differential diagnosis
International Journal of Dermatology, EarlyView.
https://ift.tt/2H37517
Lichen planus pigmentosus – An appraisal
International Journal of Dermatology, EarlyView.
https://ift.tt/2qCIbdz
Molecular interactions at the surface of extracellular vesicles
Abstract
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. One of the key features of extracellular vesicles is that they have relatively large surface compared to their volume. Some extracellular vesicle surface molecules are shared with those of the plasma membrane of the releasing cell, while other molecules are characteristic for extracellular vesicular surfaces. Besides proteins, lipids, glycans, and nucleic acids are also players of extracellular vesicle surface interactions. Being secreted and present in high number in biological samples, collectively extracellular vesicles represent a uniquely large interactive surface area which can establish contacts both with cells and with molecules in the extracellular microenvironment. Here, we provide a brief overview of known components of the extracellular vesicle surface interactome and highlight some already established roles of the extracellular vesicle surface interactions in different biological processes in health and disease.
https://ift.tt/2qABJob
Isolated splenic lymphangioma presenting as a huge mass causing anemia and abdominal distension in an adult patient: a case report
Lymphangiomas are uncommon benign lesions of lymphatic vessels very rarely affecting the spleen. Isolated involvement of the spleen in adult patients is rarely reported.
https://ift.tt/2qCsjaX
Impact of age on postoperative complication rates among elderly patients with hip fracture: a retrospective matched study
Abstract
This study was performed to assess the impact of age of ≥ 90 years on predicting postoperative complications. We retrospectively identified all patients aged ≥ 65 years who underwent surgical repair of hip fractures over a 4.5-year period in our hospital. In total, 261 patients were identified (mean age, 86.2 ± 6.8 years). Ninety-one patients were aged ≥ 90 years (oldest-old group), and the remaining 170 were aged < 89 years (control old group). Postoperative complications developed in 54 of 261 patients (20.7%). The oldest-old group had a significantly higher proportion of patients with a Japanese long-term care insurance need level and trochanteric fracture than the control group. Spinal anesthesia was more frequently performed in the oldest-old group. After propensity adjustment for these characteristics, postoperative complication rates in the oldest-old group remained significantly higher than those in the matched control group (odds ratio (OR) 2.76, 95% confidence interval (95% CI) 1.24–6.49; P = 0.011). Major complications also developed more frequently in the oldest-old group than control group (OR 9.78, 95% CI 1.31–4.36; P = 0.018). Anesthesiologists and surgeons should pay attention to potential complications following hip fracture surgery for patients aged ≥ 90 years regardless of American Society of Anesthesiologists class or social dependency.
https://ift.tt/2HqHU7W
Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis
Miliary histoplasmosis is a rare presentation that may mimic miliary tuberculosis. We report a case of miliary histoplasmosis in a 52-year-old male who was being treated with hydroxychloroquine, methotrexate, and sulfasalazine for his rheumatoid arthritis and presented to the emergency department with shortness of breath and fevers. Computed tomography (CT) chest revealed miliary pulmonary nodules. Urine Histoplasma antigen and serum Histoplasma antigen were negative; however, Coccidioides immitis complement immunofixation assay and Coccidioides IgM were positive. The patient was initiated on treatment for pulmonary coccidioidomycosis and immunosuppression was held. However, a few days later, Histoplasma capsulatum was isolated from cultures from bronchoscopy. This case highlights the difficulty in diagnosing histoplasmosis in immunocompromised patients and the importance of having a broad differential diagnosis for miliary pulmonary nodules. Tissue culture and histopathology remain the gold standard for the diagnosis of histoplasmosis. Further research needs to be conducted to determine the optimal duration of histoplasmosis treatment in immunocompromised patients.
https://ift.tt/2HBtUWE
Commentary on: Subjective cognitive decline is longitudinally associated with lower health-related quality of life
Cooper, C; (2017) Commentary on: Subjective cognitive decline is longitudinally associated with lower health-related quality of life. International Psychogeriatrics , 29 (12) p. 1937. 10.1017/S1041610217001995 . Green open access
https://ift.tt/2vhK4C2
Donor Variability in Growth Kinetics of Healthy hMSCs Using Manual Processing: Considerations for Manufacture of Cell Therapies
Detela, G; Bain, OW; Kim, H-W; Williams, DJ; Mason, C; Mathur, A; Wall, IB; (2018) Donor Variability in Growth Kinetics of Healthy hMSCs Using Manual Processing: Considerations for Manufacture of Cell Therapies. Biotechnology Journal , 13 (2) , Article 1700085. 10.1002/biot.201700085 . Green open access
https://ift.tt/2JOVAbr
Mathematical modelling of intensified extraction for spent nuclear fuel reprocessing
Bascone, D; Angeli, P; Fraga, ES; (2018) Mathematical modelling of intensified extraction for spent nuclear fuel reprocessing. Nuclear Engineering and Design , 332 pp. 162-172. 10.1016/j.nucengdes.2018.03.030 . (In press). Green open access
https://ift.tt/2EQMWp5
“I carry a serpent in my bosom, which devours me”: finance, morality and the public service in the Nine Years War, 1688-97
Graham, AB; (2018) "I carry a serpent in my bosom, which devours me": finance, morality and the public service in the Nine Years War, 1688-97. In: Felix, J, (ed.) The war within: finance and morality in earlymodern Europe. Palgrave Macmillan (In press).
https://ift.tt/2JQVb8o
Portuguese recommendations for the use of biological therapies in patients with psoriatic arthritis - 2015 update
Vieira-Sousa, E; Machado, PM; Costa, J; Ribeiro, A; Aguiar, R; Cerqueira, M; Neto, A; ... Portuguese Society of Rheumatology, .; + view all Vieira-Sousa, E; Machado, PM; Costa, J; Ribeiro, A; Aguiar, R; Cerqueira, M; Neto, A; Bernardo, A; Cordeiro, A; Duate, C; Vinagre, F; Canhão, H; Santos, H; Neves, JS; Cunha-Miranda, L; Silva, M; Santos, MJ; Bernardes, M; Bogas, M; Abreu, P; Viana-Queiroz, M; Barros, R; Falcão, S; Pimenta, S; Teixeira, V; Fonseca, JE; Barcelos, A; Portuguese Society of Rheumatology, .; - view fewer (2018) Portuguese recommendations for the use of biological therapies in patients with psoriatic arthritis - 2015 update. Acta Reumatologica Portuguesa , 2018 (1(Suppl)) pp. 36-51. Green open access
https://ift.tt/2vhoYDT
Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
Aaltonen, T; Abazov, VM; Abbott, B; Acharya, BS; Adams, M; Adams, T; Agnew, JP; ... Zucchelli, S; + view all Aaltonen, T; Abazov, VM; Abbott, B; Acharya, BS; Adams, M; Adams, T; Agnew, JP; Alexeev, GD; Alkhazov, G; Alton, A; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, JA; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Askew, A; Atkins, S; Auerbach, B; Augsten, K; Aurisano, A; Aushev, V; Aushev, Y; Avila, C; Azfar, F; Badaud, F; Badgett, W; Bae, T; Bagby, L; Baldin, B; Bandurin, DV; Banerjee, S; Barbaro-Galtieri, A; Barberis, E; Baringer, P; Barnes, VE; Barnett, BA; Barria, P; Bartlett, JF; Bartos, P; Bassler, U; Bauce, M; Bazterra, V; Bean, A; Bedeschi, F; Begalli, M; Behari, S; Bellantoni, L; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beri, SB; Bernardi, G; Bernhard, R; Bertram, I; Besancon, M; Beuselinck, R; Bhat, PC; Bhatia, S; Bhatnagar, V; Bhatti, A; Bland, KR; Blazey, G; Blessing, S; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boehnlein, A; Boline, D; Boos, EE; Borissov, G; Bortoletto, D; Borysova, M; Boudreau, J; Boveia, A; Brandt, A; Brandt, O; Brigliadori, L; Brochmann, M; Brock, R; Bromberg, C; Bross, A; Brown, D; Brucken, E; Bu, XB; Budagov, J; Budd, HS; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burkett, K; Busetto, G; Bussey, P; Buszello, CP; Butti, P; Buzatu, A; Calamba, A; Camacho-Perez, E; Camarda, S; Campanelli, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Casal, B; Casarsa, M; Casey, BCK; Castilla-Valdez, H; Castro, A; Catastini, P; Caughron, S; Cauz, D; Cavaliere, V; Cerri, A; Cerrito, L; Chakrabarti, S; Chan, KM; Chandra, A; Chapelain, A; Chapon, E; Chen, G; Chen, YC; Chertok, M; Chiarelli, G; Chlachidze, G; Cho, K; Cho, SW; Choi, S; Chokheli, D; Choudhary, B; Cihangir, S; Claes, D; Clark, A; Clarke, C; Clutter, J; Convery, ME; Conway, J; Cooke, M; Cooper, WE; Corbo, M; Corcoran, M; Cordelli, M; Couderc, F; Cousinou, M-C; Cox, CA; Cox, DJ; Cremonesi, M; Cruz, D; Cuevas, J; Culbertson, R; Cuth, J; Cutts, D; Das, A; d'Ascenzo, N; Datta, M; Davies, G; de Barbaro, P; de Jong, SJ; De La Cruz-Burelo, E; Deliot, F; Demina, R; Demortier, L; Deninno, M; Denisov, D; Denisov, SP; D'Errico, M; Desai, S; Deterre, C; DeVaughan, K; Devoto, F; Di Canto, A; Di Ruzza, B; Diehl, HT; Diesburg, M; Ding, PF; Dittmann, JR; Dominguez, A; Donati, S; D'Onofrio, M; Dorigo, M; Driutti, A; Drutskoy, A; Dubey, A; Dudko, LV; Duperrin, A; Dutt, S; Eads, M; Ebina, K; Edgar, R; Edmunds, D; Elagin, A; Ellison, J; Elvira, VD; Enari, Y; Erbacher, R; Errede, S; Esham, B; Evans, H; Evdokimov, A; Evdokimov, VN; Farrington, S; Faure, A; Feng, L; Ferbel, T; Fernandez Ramos, JP; Fiedler, F; Field, R; Filthaut, F; Fisher, W; Fisk, HE; Flanagan, G; Forrest, R; Fortner, M; Fox, H; Franc, J; Franklin, M; Freeman, JC; Frisch, H; Fuess, S; Funakoshi, Y; Galloni, C; Garbincius, PH; Garcia-Bellido, A; Garcia-Gonzalez, JA; Garfinkel, AF; Garosi, P; Gavrilov, V; Geng, W; Gerber, CE; Gerberich, H; Gerchtein, E; Gershtein, Y; Giagu, S; Giakoumopoulou, V; Gibson, K; Ginsburg, CM; Ginther, G; Giokaris, N; Giromini, P; Glagolev, V; Glenzinski, D; Gogota, O; Gold, M; Goldin, D; Golossanov, A; Golovanov, G; Gomez, G; Gomez-Ceballos, G; Goncharov, M; Gonzalez Lopez, O; Gorelov, I; Goshaw, AT; Goulianos, K; Gramellini, E; Grannis, PD; Greder, S; Greenlee, H; Grenier, G; Gris, P; Grivaz, J-F; Grohsjean, A; Grosso-Pilcher, C; Grunendahl, S; Grunewald, MW; Guillemin, T; da Costa, JG; Gutierrez, G; Gutierrez, P; Hahn, SR; Haley, J; Han, JY; Han, L; Happacher, F; Hara, K; Harder, K; Hare, M; Harel, A; Harr, RF; Harrington-Taber, T; Hatakeyama, K; Hauptman, JM; Hays, C; Hays, J; Head, T; Hebbeker, T; Hedin, D; Hegab, H; Heinrich, J; Heinson, AP; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herndon, M; Herner, K; Hesketh, G; Hildreth, MD; Hirosky, R; Hoang, T; Hobbs, JD; Hocker, A; Hoeneisen, B; Hogan, J; Hohlfeld, M; Holzbauer, JL; Hong, Z; Hopkins, W; Hou, S; Howley, I; Hubacek, Z; Hughes, RE; Husemann, U; Hussein, M; Huston, J; Hynek, V; Iashvili, I; Ilchenko, Y; Illingworth, R; Introzzi, G; Iori, M; Ito, AS; Ivanov, A; Jabeen, S; Jaffre, M; James, E; Jang, D; Jayasinghe, A; Jayatilaka, B; Jeon, EJ; Jeong, MS; Jesik, R; Jiang, P; Jindariani, S; Johns, K; Johnson, E; Johnson, M; Jonckheere, A; Jones, M; Jonsson, P; Joo, KK; Joshi, J; Jun, SY; Jung, AW; Junk, TR; Juste, A; Kajfasz, E; Kambeitz, M; Kamon, T; Karchin, PE; Karmanov, D; Kasmi, A; Kato, Y; Katsanos, I; Kaur, M; Kehoe, R; Kermiche, S; Ketchum, W; Keung, J; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, YN; Kilminster, B; Kim, DH; Kim, HS; Kim, JE; Kim, MJ; Kim, SH; Kim, SB; Kim, YJ; Kim, YK; Kimura, N; Kirby, M; Kiselevich, I; Kohli, JM; Kondo, K; Kong, DJ; Konigsberg, J; Kotwal, AV; Kozelov, AV; Kraus, J; Kreps, M; Kroll, J; Kruse, M; Kuhr, T; Kumar, A; Kupco, A; Kurata, M; Kurca, T; Kuzmin, VA; Laasanen, AT; Lammel, S; Lammers, S; Lancaster, M; Lannon, K; Latino, G; Lebrun, P; Lee, HS; Lee, JS; Lee, SW; Lee, WM; Lei, X; Lellouch, J; Leo, S; Leone, S; Lewis, JD; Li, D; Li, H; Li, L; Li, QZ; Lim, JK; Limosani, A; Lincoln, D; Linnemann, J; Lipaev, VV; Lipeles, E; Lipton, R; Lister, A; Liu, H; Liu, Q; Liu, T; Liu, Y; Lobodenko, A; Lockwitz, S; Loginov, A; Lokajicek, M; de Sa, RL; Lucchesi, D; Luca, A; Lueck, J; Lujan, P; Lukens, P; Luna-Garcia, R; Lungu, G; Lyon, AL; Lys, J; Lysak, R; Maciel, AKA; Madar, R; Madrak, R; Maestro, P; Magana-Villalba, R; Malik, S; Malyshev, VL; Manca, G; Manousakis-Katsikakis, A; Mansour, J; Marchese, L; Margaroli, F; Marino, P; Martinez-Ortega, J; Matera, K; Mattson, ME; Mazzacane, A; Mazzanti, P; McCarthy, R; McGivern, CL; McNulty, R; Mehta, A; Mehtala, P; Meijer, MM; Melnitchouk, A; Menezes, D; Mercadante, PG; Merkin, M; Mesropian, C; Meyer, A; Meyer, J; Miao, T; Miconi, F; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondal, NK; Moon, CS; Moore, R; Morello, MJ; Mukherjee, A; Mulhearn, M; Muller, T; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nagy, E; Nakano, I; Napier, A; Narain, M; Nayyar, R; Neal, HA; Negret, JP; Nett, J; Neustroev, P; Nguyen, HT; Nigmanov, T; Nodulman, L; Noh, SY; Norniella, O; Nunnemann, T; Oakes, L; Oh, SH; Oh, YD; Okusawa, T; Orava, R; Orduna, J; Ortolan, L; Osman, N; Pagliarone, C; Pal, A; Palencia, E; Palni, P; Papadimitriou, V; Parashar, N; Parihar, V; Park, SK; Parker, W; Partridge, R; Parua, N; Patwa, A; Pauletta, G; Paulini, M; Paus, C; Penning, B; Perfilov, M; Peters, Y; Petridis, K; Petrillo, G; Petroff, P; Phillips, TJ; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pleier, M-A; Podstavkov, VM; Pondrom, L; Popov, AV; Poprocki, S; Potamianos, K; Pranko, A; Prewitt, M; Price, D; Prokopenko, N; Prokoshin, F; Ptohos, F; Punzi, G; Qian, J; Quadt, A; Quinn, B; Ratoff, PN; Razumov, I; Redondo Fernandez, I; Renton, P; Rescigno, M; Rimondi, F; Ripp-Baudot, I; Ristori, L; Rizatdinova, F; Robson, A; Rodriguez, T; Rolli, S; Rominsky, M; Ronzani, M; Roser, R; Rosner, JL; Ross, A; Royon, C; Rubinov, P; Ruchti, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Sajot, G; Sakumoto, WK; Sakurai, Y; Sanchez-Hernandez, A; Sanders, MP; Santi, L; Santos, AS; Sato, K; Savage, G; Saveliev, V; Savitskyi, M; Savoy-Navarro, A; Sawyer, L; Scanlon, T; Schamberger, RD; Scheglov, Y; Schellman, H; Schlabach, P; Schmidt, EE; Schott, M; Schwanenberger, C; Schwarz, T; Schwienhorst, R; Scodellaro, L; Scuri, F; Seidel, S; Seiya, Y; Sekaric, J; Semenov, A; Severini, H; Sforza, F; Shabalina, E; Shalhout, SZ; Shary, V; Shaw, S; Shchukin, AA; Shears, T; Shepard, PF; Shimojima, M; Shkola, O; Shochet, M; Shreyber-Tecker, I; Simak, V; Simonenko, A; Skubic, P; Slattery, P; Sliwa, K; Smith, JR; Snider, FD; Snow, GR; Snow, J; Snyder, S; Soldner-Rembold, S; Song, H; Sonnenschein, L; Sorin, V; Soustruznik, K; Denis, RS; Stancari, M; Stark, J; Stefaniuk, N; Stentz, D; Stoyanova, DA; Strauss, M; Strologas, J; Sudo, Y; Sukhanov, A; Suslov, I; Suter, L; Svoisky, P; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, PK; Thom, J; Thomson, E; Thukral, V; Titov, M; Toback, D; Tokar, S; Tokmenin, VV; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Tsai, Y-T; Tsybychev, D; Tuchming, B; Tully, C; Ukegawa, F; Uozumi, S; Uvarov, L; Uvarov, S; Uzunyan, S; Van Kooten, R; van Leeuwen, WM; Varelas, N; Varnes, EW; Vasilyev, IA; Vazquez, F; Velev, G; Vellidis, C; Verkheev, AY; Vernieri, C; Vertogradov, LS; Verzocchi, M; Vesterinen, M; Vidal, M; Vilanova, D; Vilar, R; Vizan, J; Vogel, M; Vokac, P; Volpi, G; Wagner, P; Wahl, HD; Wallny, R; Wang, MHLS; Wang, SM; Warchol, J; Waters, D; Watts, G; Wayne, M; Weichert, J; Welty-Rieger, L; Wester, WC; Whiteson, D; Wicklund, AB; Wilbur, S; Williams, HH; Williams, MRJ; Wilson, GW; Wilson, JS; Wilson, P; Winer, BL; Wittich, P; Wobisch, M; Wolbers, S; Wolfmeister, H; Wood, DR; Wright, T; Wu, X; Wu, Z; Wyatt, TR; Xie, Y; Yamada, R; Yamamoto, K; Yamato, D; Yang, S; Yang, T; Yang, UK; Yang, YC; Yao, W-M; Yasuda, T; Yatsunenko, YA; Ye, W; Ye, Z; Yeh, GP; Yi, K; Yin, H; Yip, K; Yoh, J; Yorita, K; Yoshida, T; Youn, SW; Yu, GB; Yu, I; Yu, JM; Zanetti, AM; Zeng, Y; Zennamo, J; Zhao, TG; Zhou, B; Zhou, C; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L; Zucchelli, S; - view fewer (2018) Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron. Physical Review Letters , 120 (4) , Article 042001. 10.1103/PhysRevLett.120.042001 . Green open access
https://ift.tt/2JQUOe0
Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor
Frampton, D; Schwenzer, H; Marino, G; Butcher, LM; Pollara, G; Kriston-Vizi, J; Venturini, C; ... Fassati, A; + view all Frampton, D; Schwenzer, H; Marino, G; Butcher, LM; Pollara, G; Kriston-Vizi, J; Venturini, C; Austin, R; de Castro, KF; Ketteler, R; Chain, B; Goldstein, RA; Weiss, RA; Beck, S; Fassati, A; - view fewer (2018) Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell , 33 (4) 620-633.e6. 10.1016/j.ccell.2018.03.003 . Green open access
https://ift.tt/2vjKibP
Recommendations made by the Portuguese Society of Rheumatology: A contribution for a high-quality clinical practice
Machado, P; Santos, MJ; Fonseca, JE; (2018) Recommendations made by the Portuguese Society of Rheumatology: A contribution for a high-quality clinical practice. Acta Reumatologica Portuguesa , 2018 (1) pp. 19-20. (In press).
https://ift.tt/2JMR1hX
Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery
A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients.
https://ift.tt/2vj5UFw
Lethal Weapon: Data Show More Prehospital Deaths, a Potential Increase in Intensity of Violence
A new Johns Hopkins Medicine analysis of national trauma data shows that trauma patients were four times more likely to die from gunshot wounds and nearly nine times more likely to die from stab wounds before getting to a trauma center in 2014, compared with rates in 2007.
https://ift.tt/2JPaiis
Atypical Presentation of Meckel’s Diverticulum in a Hispanic Man: A Case Report
Abstract
The incidence of Meckel's diverticulum is 2% in the general population. Although most commonly found in children as painless rectal bleeding, in adults, obstruction, inflammation, and perforation are the usual manifestations. We present the case of a 32 year old man who arrived at our institution with hematochezia and symptomatic anemia. A large Meckel's diverticulum was encountered during work-up and treated by segmental small bowel resection. A literature review, including disease presentation, pathology findings, and treatment options is discussed.https://ift.tt/2vqTn2X
Evidence Mounts that Daily Opioid Users May Fare Worse After Spine Surgery, Study Finds
In a multicenter database study of adults who had undergone surgery for spinal deformities, researchers say that those who had used narcotics daily on average had worse outcomes, such as longer intensive care unit stays and more severe postop disability, compared with those who did not use opioids preoperatively.
https://ift.tt/2IZnnVh
Ambient Air Pollution and Asthma-Related Outcomes in Children of Color of the USA: a Scoping Review of Literature Published Between 2013 and 2017
Abstract
Purpose of Review
Given racial disparities in ambient air pollution (AAP) exposure and asthma risk, this review offers an overview of the literature investigating the ambient air pollution-asthma relationship in children of color between 2013 and 2017.
Recent Findings
AAP is likely a key contributor to the excess burden of asthma in children of color due to pervasive exposure before birth, at home, and in school. Recent findings suggest that psychosocial stressors may modify the relationship between AAP and asthma.
Summary
The effect of AAP on asthma in children of color is likely modulated by multiple unique psychosocial stressors and gene-environment interactions. Although children of color are being included in asthma studies, more research is still needed on impacts of specific criteria pollutants throughout the life course. Additionally, future studies should consider historical factors when analyzing current exposure profiles.
https://ift.tt/2HsCJ7A
Introduction: Articulating Intersections at the Global Crossroads of Religion and Migration
Fiddian-Qasmiyeh, E; Snyder, S; Saunders, J; (2016) Introduction: Articulating Intersections at the Global Crossroads of Religion and Migration. In: Saunders, J and Fiddian-qasmiyeh, E and Snyder, S, (eds.) Intersections of religion and migration: Issues at the global crossroad. Palgrave Macmillan: New York, New York.
https://ift.tt/2HBad1a
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Walzl, G; McNerney, R; Du Plessis, N; Bates, M; McHugh, TD; Chegou, NN; Zumla, A; (2018) Tuberculosis: advances and challenges in development of new diagnostics and biomarkers. The Lancet Infectious Diseases 10.1016/S1473-3099(18)30111-7 . (In press).
https://ift.tt/2J1xvg7
Regimes of Flow over Complex Structures of Endothelial Glycocalyx: A Molecular Dynamics Simulation Study
Jiang, XZ; Feng, M; Ventikos, Y; Luo, KH; (2018) Regimes of Flow over Complex Structures of Endothelial Glycocalyx: A Molecular Dynamics Simulation Study. Scientific Reports , 8 (1) , Article 5732. 10.1038/s41598-018-24041-7 . Green open access
https://ift.tt/2HEtT4n
Direct numerical simulation study of hydrogen/air auto-ignition in turbulent mixing layer at elevated pressures
Luo, K; Yao, T; Yang, W; (2018) Direct numerical simulation study of hydrogen/air auto-ignition in turbulent mixing layer at elevated pressures. Computers and Fluids 10.1016/j.compfluid.2018.03.075 . (In press). Green open access
https://ift.tt/2IYeg7d
Physically Active Lessons Improve Lesson Activity and On-Task Behavior: A Cluster-Randomized Controlled Trial of the "Virtual Traveller" Intervention
Norris, E; Dunsmuir, S; Duke-Williams, O; Stamatakis, E; Shelton, N; (2018) Physically Active Lessons Improve Lesson Activity and On-Task Behavior: A Cluster-Randomized Controlled Trial of the "Virtual Traveller" Intervention. Health Education & Behavior 10.1177/1090198118762106 . (In press). Green open access
https://ift.tt/2HCOI00
Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers
Winters, Z; Horsnell, J; Elvers, KT; Maxwell, AJ; Jones, LJ; Shaaban, AM; Schmid, P; ... Brunt, AM; + view all Winters, Z; Horsnell, J; Elvers, KT; Maxwell, AJ; Jones, LJ; Shaaban, AM; Schmid, P; Williams, NR; Beswick, A; Greenwood, R; Ingram, JC; Saunders, C; Vaidya, JS; Esserman, L; Jatoi, I; Brunt, AM; - view fewer (2018) Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers. British Journal of Surgery 10.1002/bjs5.53 . (In press).
https://ift.tt/2J1xj0n
Bank integration and co-movements across housing markets
Milcheva, S; Zhu, B; (2016) Bank integration and co-movements across housing markets. Journal of Banking & Finance , 72 (S) S148-S171. 10.1016/j.jbankfin.2015.07.002 . Green open access
https://ift.tt/2HD0Jmf
Bystander Responses to Bias‐Based Bullying in Schools: A Developmental Intergroup Approach
Palmer, SB; Abbott, N; (2018) Bystander Responses to Bias‐Based Bullying in Schools: A Developmental Intergroup Approach. Child Development Perspectives , 12 (1) pp. 39-44. 10.1111/cdep.12253 .
https://ift.tt/2H6TEsQ
Effect of Bearing Type on Taper Material Loss in Hips From 1 Manufacturer
Hothi, HS; Eskelinen, AP; Henckel, J; Kwon, Y-M; Blunn, GW; Skinner, JA; Hart, AJ; (2017) Effect of Bearing Type on Taper Material Loss in Hips From 1 Manufacturer. The Journal of Arthroplasty 10.1016/j.arth.2017.12.022 . (In press).
https://ift.tt/2HCOuGc
Delineating the psychiatric and behavioral phenotype of recurrent 2q13 deletions and duplications
Wolfe, K; McQuillin, A; Alesi, V; Boudry Labis, E; Cutajar, P; Dallapiccola, B; Dentici, ML; ... Bass, N; + view all Wolfe, K; McQuillin, A; Alesi, V; Boudry Labis, E; Cutajar, P; Dallapiccola, B; Dentici, ML; Dieux-Coeslier, A; Duban-Bedu, B; Duelund Hjortshøj, T; Goel, H; Loddo, S; Morrogh, D; Mosca-Boidron, A-L; Novelli, A; Olivier-Faivre, L; Parker, J; Parker, MJ; Patch, C; Pelling, AL; Smol, T; Tümer, Z; Vanakker, O; van Haeringen, A; Vanlerberghe, C; Strydom, A; Skuse, D; Bass, N; - view fewer (2018) Delineating the psychiatric and behavioral phenotype of recurrent 2q13 deletions and duplications. American Journal of Medical Genetics: Part B Neuropsychiatric Genetics 10.1002/ajmg.b.32627 . (In press). Green open access
https://ift.tt/2J1wTHl
Patient experience of nasal obstruction and its clinical assessment
Nip, L; Tan, M; Whitcroft, KL; Gupta, R; Leung, TS; Andrews, P; (2018) Patient experience of nasal obstruction and its clinical assessment. The Journal of Laryngology & Otology 10.1017/S0022215117002146 . (In press).
https://ift.tt/2HCOm9G
Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1
Tijchon, E; van Emst, L; Yuniati, L; van Ingen Schenau, D; Gerritsen, M; van der Meer, LT; Williams, O; ... van Leeuwen, FN; + view all Tijchon, E; van Emst, L; Yuniati, L; van Ingen Schenau, D; Gerritsen, M; van der Meer, LT; Williams, O; Hoogerbrugge, PM; Scheijen, B; van Leeuwen, FN; - view fewer (2018) Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1. Experimental Hematology , 60 57-62.e3. 10.1016/j.exphem.2018.01.006 .
https://ift.tt/2H6TaD2
Effective delivery of hydrophobic drugs to breast (MCF-7) and Liver (HepG2) cancer cells: A detailed investigation using Cytotoxicity assays, fluorescence imaging and flow cytometry
Manatunga, DC; de Silva, RM; Nalin de Silva, KM; Neelika Malavige, G; Wijeratne, DT; Williams, GR; Jayasinghe, CD; Manatunga, DC; de Silva, RM; Nalin de Silva, KM; Neelika Malavige, G; Wijeratne, DT; Williams, GR; Jayasinghe, CD; Udagama, PV; - view fewer (2018) Effective delivery of hydrophobic drugs to breast (MCF-7) and Liver (HepG2) cancer cells: A detailed investigation using Cytotoxicity assays, fluorescence imaging and flow cytometry. European Journal of Pharmaceutics and Biopharmaceutics 10.1016/j.ejpb.2018.04.001 . (In press).
https://ift.tt/2HEdoFE
Ambient Air Pollution and Asthma-Related Outcomes in Children of Color of the USA: a Scoping Review of Literature Published Between 2013 and 2017
Abstract
Purpose of Review
Given racial disparities in ambient air pollution (AAP) exposure and asthma risk, this review offers an overview of the literature investigating the ambient air pollution-asthma relationship in children of color between 2013 and 2017.
Recent Findings
AAP is likely a key contributor to the excess burden of asthma in children of color due to pervasive exposure before birth, at home, and in school. Recent findings suggest that psychosocial stressors may modify the relationship between AAP and asthma.
Summary
The effect of AAP on asthma in children of color is likely modulated by multiple unique psychosocial stressors and gene-environment interactions. Although children of color are being included in asthma studies, more research is still needed on impacts of specific criteria pollutants throughout the life course. Additionally, future studies should consider historical factors when analyzing current exposure profiles.
https://ift.tt/2HsCJ7A
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