Author index∗∗July, pp. 1-196; August, pp. 197-390; September, pp. 391-590; October, pp. 591-794; November, pp. 795-994; December, pp. 995-1252.

Aboul-Fettouh N, Hinojosa J, Tovar-Garza A, Pandya AG. The majority of patients presenting with vitiligo have a clinical sign of activity. 2017;77:774-5 (Research letter)

http://ift.tt/2zyDJ5G

Subject index

Academic medical centers

http://ift.tt/2higrH8

Editorial Board

http://ift.tt/2zxXESu

Topical 15% resorcinol for hidradenitis suppurativa: An uncontrolled prospective trial with clinical and ultrasonographic follow-up

To the Editor: Boer and Jemec first described the use of topical 15% resorcinol for hidradenitis suppurativa (HS) in a small retrospective study in 2010,1 reporting a marked decrease in pain and mean duration of the lesions. In this study we assessed the effects of resorcinol in a prospective open trial in HS by using both clinical measures and ultrasonography. Ultrasound examination in HS provides anatomic information that is clinically unavailable and may be helpful for follow-up.2,3 We recruited participants with Hurley stage I and II HS.

http://ift.tt/2hm7UD6

The water-drop test for the diagnosis of koilonychia

Koilonychia is a common concave nail dystrophy in which the nail plate is depressed centrally and elevated laterally.1 The term has Greek origins, with koilos meaning spoon. The pathophysiology of koilonychia, or spoon nails, is poorly understood. It has been associated with dermatologic disorders such as alopecia areata, psoriasis, and lichen planus; endocrinopathies such as hypothyroidism, hyperthyroidism, and diabetes mellitus; nutritional deficiencies, notably iron deficiency anemia; genodermatoses; and traumatic and occupational exposures.

http://ift.tt/2zA52gh

Doctors' mental health, burnout, and suicidality: Professional and ethical issues in the workplace

This case scenario engenders multiple ethical and professional issues for practicing dermatologists and dermatology residents, the most central of which are mental health and suicidality among physicians. When a physician's mental health is compromised, so may the safety and quality of the medical care provided. If a physician's mental state deteriorates to the point that his or her practice becomes impaired and professional obligations cannot be safely carried out, and the physician refuses to seek help, there is an ethical responsibility for a colleague(s) to report the impaired practitioner to an appropriate body or licensing authority.

http://ift.tt/2hks7Jf

Cover Sheet for Index

http://ift.tt/2zyDBDe

Circumventing iPLEDGE: Circumventing ethical responsibility?

Prescribing isotretinoin in the United States is regulated through iPLEDGE, a program aimed at reducing the risk for fetal exposure to isotretinoin. Isotretinoin is a pregnancy category X medication and is associated with major birth defects affecting 4%-28% of exposed fetuses.1,2 This Food and Drug Administration—approved program strives to ensure that no woman of child-bearing potential starts the medication while pregnant or becomes pregnant while on the medication. It is a centralized pregnancy risk management program requiring registration from all parties involved in the chain of distribution: wholesalers, prescribers, pharmacies, and patients.

http://ift.tt/2hm7Q6k

Injection of filler for volume replacement of the whole face using a single-entry method

Many practitioners use the standard approach of injecting fillers through multiple points into the area of a defect. In the midface, physicians will inject the cheeks and the tear troughs through different sets of entry points. Although the results of this method are acceptable, the risk of bruising is high.

http://ift.tt/2zyDA28

Dermatology Calendar

http://ift.tt/2hl2LeA

Iotaderma #286

http://ift.tt/2zyDxDu

Lymphedema

Lymphedema is a localized form of tissue swelling resulting from excessive retention of lymphatic fluid in the interstitial compartment and caused by impaired lymphatic drainage. Lymphedema is classified as primary or secondary. Primary lymphedema is caused by developmental lymphatic vascular anomalies. Secondary lymphedema is acquired and arises as a result of an underlying systemic disease, trauma, or surgery. We performed PubMed and Google Scholar searches of the English-language literature (1966-2017) using the terms lymphedema, cancer-related lymphedema, and lymphatic complications.

http://ift.tt/2hl2IPW

A novel clinical sign to aid in the diagnosis of superficial basal cell carcinoma

Basal cell carcinoma (BCC) is the most common type of skin cancer worldwide.1 The diagnosis of BCC is often made clinically and confirmed histologically. Superficial BCCs, which represent a common histologic subtype, characteristically present as bright pink plaques or patches with variable scale.2 Even for experienced dermatologists, some superficial BCCs might elude early detection because of their variable color, ranging from skin-colored to bright pink. Early superficial BCCs are easier to treat and associated with less morbidity.

http://ift.tt/2zwPqtT

Inpatient dermatology consultations: Motivation and practice of requesting providers

To the Editor: Given limited access to inpatient dermatology services, inpatient dermatologic management is handled by primary teams.1-4 These teams (eg, medicine, intensive care services, surgery) must decide when it is necessary to request dermatologic expert opinion, though many hospitals lack access to inpatient dermatology consults.4 When available, the decision to call a consult is unique and complex, shaped by patient-driven and provider-driven factors. Our aim was to survey inpatient providers prospectively to capture the factors that inform their decision to request dermatology consults and to characterize the perceived utility of the inpatient consult service.

http://ift.tt/2hl2Gri

The hungry caterpillar flap: A variant of the V-to-Y island pedicle flap

Subcutaneous and myocutaneous island pedicle flaps are versatile closure options that are able to close large surgical defects with robust vascular supply.1 However, one of the shortcomings of these closures is the formation of triangular scars. Straight lines are visually arresting and the triangular scars created by island pedicle flaps can be distinctly conspicuous.

http://ift.tt/2zzXvOb

Information for Readers

http://ift.tt/2hl2DM8

Correction of vermilion lip retraction after mucosal advancement flap: A countertraction technique

Squamous cell carcinoma of the lip accounts for a third of all oral cavity cancers in the United States, and the lower lip is the most frequent site of occurence.1 Surgical resection is the mainstay of treatment. Several size-dependent options can be utilized for repair: a small defect can be closed with a simple primary closure, whereas a local flap or skin graft is required for massive tissue loss. The mucosal advancement flap is a useful method with satisfactory results for large vermilion lip defects.

http://ift.tt/2zyDt6I

High-risk category for early annual ophthalmology screening of patients receiving hydroxychloroquine

To the Editor: Although the recent article "Updated recommendations on the use of hydroxychloroquine in dermatologic practice" by Fernandez was overall both excellent and timely,1 I wish to offer a comment of clarification on the use of annual screening among hydroxychloroquine users. In the article, the author states, "Annual ocular toxicity screening is recommended to begin only after 5 years of use unless patients are considered high-risk or develop ophthalmologic symptoms." However, there are 2 caveats to this statement.

http://ift.tt/2hm7EnC

November iotaderma (#285)

http://ift.tt/2zyDiZ6

Reply to: Comment on “Efficacy and safety of etanercept and adalimumab with and without a loading dose for psoriasis: A systematic review”

To the Editor: We would like to thank Dr Asahina and Dr Nakagawa1 for taking interest in our publication entitled "Efficacy and safety of etanercept and adalimumab with and without a loading dose for psoriasis: A systematic review."2 In our initial assessment of their clinical trial report (M04-688; NCT00338754), we were not able to infer any statistical difference in efficacy between the 2 dosing regimens, 40 mg every other week (EOW) and 80-mg loading dose followed by 40 mg EOW.3 However, we are pleased to learn that a statistical analysis directly comparing the efficacy of the 2 groups was completed and established a more rapid improvement of psoriatic plaques with the regimen including a loading dose.

http://ift.tt/2hkXIdZ

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid , Vol. 0, No. 0.


http://ift.tt/2yqJzmg

Are Evidence-Based Guidelines Reflected in Clinical Practice? An Analysis of Prospectively Collected Data of the Italian Thyroid Cancer Observatory

Thyroid , Vol. 0, No. 0.


http://ift.tt/2AzGMIW

Editorial Board

Publication date: December 2017
Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 28, Issue 4





http://ift.tt/2i2OS5q

Contents

Publication date: December 2017
Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 28, Issue 4





http://ift.tt/2AtIJpK

Future and recent issues

Publication date: December 2017
Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 28, Issue 4





http://ift.tt/2i4e4Z3

Information for authors

Publication date: December 2017
Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 28, Issue 4





http://ift.tt/2AtC5zI

Masthead

Publication date: December 2017
Source:Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 28, Issue 4





http://ift.tt/2i33e5P

Highlights in immune response, microbiome and precision medicine in allergic disease and asthma

Milena Sokolowska | Cezmi A. Akdis

http://ift.tt/2jjmGOV

Eine seltene Differentialdiagnose des supraglottischen Larynxödems

Laryngo-Rhino-Otol
DOI: 10.1055/s-0043-121343

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

http://ift.tt/2meTB8p

New routes of allergen immunotherapy

Publication date: Available online 10 November 2017
Source:Allergologia et Immunopathologia
Author(s): C.R. Juesas, C.M. Aguilar, S. Vieths




http://ift.tt/2mfOUv0

Dermatology and its unique diagnostic heuristics

http://ift.tt/2jfRXT3

Unrelated immunodeficiency states may impact outcomes and immune checkpoint molecule expression in patients with mycosis fungoides: A clinicopathologic case-control study

Immunodeficiency (ID) correlates with worse outcomes and decreased immune checkpoint molecule expression in melanoma. The impact of ID in mycosis fungoides (MF) is unknown.

http://ift.tt/2yqWa9a

Adherence with epinephrine autoinjector prescriptions in primary care

The aim of this study was to estimate primary adherence for epinephrine autoinjector (EA) prescriptions in primary care practices in Manitoba, Canada.

http://ift.tt/2AzC3XZ

An infrequent case of anaphylaxis

We present the case of a 40-year-old woman with no relevant background. On December 29, 2014, immediately after eating pizza (made with turkey, cheese, onion, tomato, buckwheat, and oregano) and eggplant with baked cheese, she presented with intense diaphoresis, generalized erythema, abdominal pain, dyspnea, foreign body sensation in the throat, and unconsciousness with urinary and fecal incontinence for 15 minutes.

http://ift.tt/2yRQ9Xh

Tailored resections in oral and oropharyngeal cancer using narrow band imaging

In a previous pilot study we observed that intra-operative narrow-band imaging (NBI) helps achieve clear superficial resection margins. The aim of this study was to verify if the use of intra-operative NBI can help to obtain tailored resections and if it is influenced by the lesion site, aspects not investigated in our previous study.

http://ift.tt/2jglNH8

Cancer Pioneer Donald Coffey, Ph.D., Dies at 85

Donald Coffey, a distinguished Johns Hopkins professor and prostate cancer expert, who was the former director of the Brady Urological Research Laboratory and deputy director of the Johns Hopkins Kimmel Cancer Center, died on Nov. 9 at the age of 85.

http://ift.tt/2AzYJak

Intrahepatic biliary cystadenoma mimicking hydatid cyst of liver: a clinicopathologic study of six cases

Intrahepatic biliary cystadenomas are rare hepatic neoplasms, which are usually cystic. These tumors are often misdiagnosed as simple liver cysts and hydatid cysts clinically and radiologically owing to nonspe...

http://ift.tt/2i1W0it

Monocyte-Derived Procoagulant Microvesicles Induced by High Glucose Can Be Attenuated by the Antioxidant N-Acetyl-L-Cysteine, Partly Through the P38/MAPK Pathway

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.


http://ift.tt/2hqhys6

Blood glucose concentrations in prehospital trauma patients with traumatic shock: A retrospective analysis

BACKGROUND Deranged glucose metabolism after moderate to severe trauma with either high or low concentrations of blood glucose is associated with poorer outcome. Data on prehospital blood glucose concentrations and trauma are scarce. OBJECTIVES The primary aim was to describe the relationship between traumatic shock and prehospital blood glucose concentrations. The secondary aim was to determine the additional predictive value of prehospital blood glucose concentration for traumatic shock when compared with vital parameters alone. DESIGN Retrospective analysis of the predefined, observational database of a nationwide Helicopter Emergency Medical Service (34 bases). SETTING Emergency trauma patients treated by Helicopter Emergency Medical Service between 2005 and 2013 were investigated. PATIENTS All adult trauma patients (≥18 years) with recorded blood glucose concentrations were enrolled. OUTCOMES Primary outcome: upper and lower thresholds of blood glucose concentration more commonly associated with traumatic shock. Secondary outcome: additional predictive value of prehospital blood glucose concentrations when compared with vital parameters alone. RESULTS Of 51 936 trauma patients, 20 177 were included. In total, 220 (1.1%) patients died on scene. Hypoglycaemia (blood glucose concentration 2.8 mmol l−1 or less) was observed in 132 (0.7%) patients, hyperglycaemia (blood glucose concentration exceeding 15 mmol l−1) was observed in 265 patients (1.3%). Blood glucose concentrations more than 10 mmol l−1 (n = 1308 (6.5%)) and 2.8 mmol l−1 or less were more common in patients with traumatic shock (P 

http://ift.tt/2mfIqws

The Authors’ Reply

No abstract available

http://ift.tt/2hioP9v

Should persistent hepatitis E virus replication in transplant patients be tolerated?

No abstract available

http://ift.tt/2zytkaj

Developing A Risk Score to Predict Long-Term Adverse Outcomes After Kidney Transplantation

No abstract available

http://ift.tt/2hjwCDT

Chronic airway fibrosis in orthotopic mouse lung transplantation models - an experimental reappraisal?

No abstract available

http://ift.tt/2zxNlO4

The Authors’ Reply

No abstract available

http://ift.tt/2hiYLLl

Reconstruction of oral cavity defect using versatile buccinator myomucosal flaps in the treatment of cT2–3, N0 oral cavity squamous cell carcinoma: Feasibility, morbidity, and functional/oncological outcomes

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Dongbin Ahn, Gil Joon Lee, Jin Ho Sohn
ObjectivesTo evaluate the results of oral cavity reconstruction using various types of buccinator myomucosal flap (BMMF) for the treatment of cT2–3 oral cavity squamous cell carcinoma (OCSCC).Materials and methodsTwenty-two consecutive patients who underwent surgical management for OCSCC and reconstruction using various types of BMMF were enrolled. Surgical results, complications, speech/swallowing outcomes, and recurrence were evaluated.ResultsThe mean flap harvest time was 28.6 min. Complete flap necrosis occurred in one (4.5%) patient in whom an island flap was used. There were no other major complications. All patients demonstrated normal speech and swallowing functions, with articulation correctness >90% and a mean swallowing satisfaction score of 9.6. Occult neck lymph node metastasis was found in three (13.6%) patients; however, no recurrence at level I was observed.ConclusionsReconstruction of the oral cavity using various types of BMMF is feasible for treatment of cT2–3 OCSCC, and yields favorable outcomes with minimal morbidity.



http://ift.tt/2i1T2KC

Prognostic value of masticatory muscle involvement in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Min Kang, Pingting Zhou, Xueyin Liao, Meng Xu, Rensheng Wang
Background and PurposeIn 2017, the 8th edition of the nasopharyngeal carcinoma (NPC) staging manual published by the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) defined new rules regarding the involvement of anatomical masticatory muscles (MM). The purpose of this study is to evaluate the validity of the current T-staging system after the addition of revisions regarding MM involvement.MethodsWe performed a retrospective review of 608 patients, who were newly diagnosed with NPC and treated with intensity-modulated radiotherapy (IMRT) between January 2008 and March 2010.ResultsWe found MM involvement in 398 NPC cases (65.4%). We observed a significant difference in overall survival (OS; 75.6% vs. 86.7%, P = .043) and in local relapse-free survival (LRFS; 81.5% vs. 88.6%, P = .048) between patients with and without MM involvement, but no difference in distant metastasis-free survival (DMFS; 80.3% vs. 85.0%, P = .147) or disease-free survival (DFS; 77.9% vs. 81.6%, P = .081). Significant differences in OS and LRFS were also found among different types of MM involvement. Compared with patients who had concurrent involvement of the lateral pterygoid muscle (LP), patients with tumors invading only the medial pterygoid muscle (MP) had a higher OS and LRFS rates, according to univariate and multivariate analysis (P < .05).ConclusionsMM involvement is an independent prognostic factor for OS and LRFS. We conclude that the decision to down-stage MP as T2 in the 8th edition staging system is valid. However, tumors with LP involvement were more rational classified into a higher T-staging category than tumors with only-MP involvement.



http://ift.tt/2AsCwKH

Oncogenic DNA viruses found in salivary gland tumors

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Alyce A. Chen, Tarik Gheit, Marco Stellin, Valentina Lupato, Giacomo Spinato, Roberto Fuson, Anna Menegaldo, Sandrine Mckay-Chopin, Elisa Dal Cin, Giancarlo Tirelli, Maria Cristina Da Mosto, Massimo Tommasino, Paolo Boscolo-Rizzo
BackgroundPrevious investigations studying the association of DNA viruses with salivary gland tumors (SGTs) have led to conflicting results. The aim of this study was to determine the prevalence of different DNA viruses by using a highly sensitive assay in a multi-center series of over 100 fresh frozen salivary gland samples.MethodsDNA was isolated from 84 SGTs (80 parotid tumors and 4 submandibular gland tumors) and 28 normal salivary tissue samples from 85 patients in Northeast Italy. Using a highly sensitive type-specific multiplex genotyping assay, we analyzed the samples for the presence of DNA from 62 different viruses including 47 papillomaviruses, 10 polyomaviruses, and 5 herpesviruses.ResultsWe observed a high prevalence of beta human papillomavirus DNA in malignant tumors. In contrast, polyomavirus DNA was present in benign, malignant, and non-tumor control samples. Most striking was the significant distribution of herpesvirus DNA in the SGT samples, in particular the high prevalence of Epstein-Barr type 1 and type 2 DNA in Warthin's tumor samples.ConclusionOur data provides evidence for the presence of DNA viruses in SGTs. Mechanistic studies are needed to further attribute tumor formation to these viruses.



http://ift.tt/2i1BkXJ

Construction of mass spectra database and diagnosis algorithm for head and neck squamous cell carcinoma

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Kei Ashizawa, Kentaro Yoshimura, Hisashi Johno, Tomohiro Inoue, Ryohei Katoh, Satoshi Funayama, Kaname Sakamoto, Sen Takeda, Keisuke Masuyama, Tomokazu Matsuoka, Hiroki Ishii
ObjectivesIntraoperative identification of tumor margins is essential to achieving complete tumor resection. However, the process of intraoperative pathological diagnosis involves cumbersome procedures, such as preparation of cryosections and microscopic examination, thus requiring more than 30 min. Moreover, intraoperative diagnoses made by examining cryosections are occasionally inconsistent with postoperative diagnoses made by examining paraffin-embedded sections because the former are of poorer quality. We sought to establish a more rapid accurate method of intraoperative assessment.Materials and methodsA diagnostic algorithm of head and neck squamous cell carcinoma (HNSCC) using machine learning was constructed by mass spectra obtained from 15 non-cancerous and 19 HNSCC specimens by probe electrospray ionization mass spectrometry (PESI-MS). The clinical validity of this system was evaluated using intraoperative specimens of HNSCC and normal mucosa.ResultsA total of 114 and 141 mass spectra were acquired from non-cancerous and cancerous specimens, respectively, using both positive- and negative-ion modes of PESI-MS. These data were fed into partial least squares-logistic regression (PLS-LR) to discriminate tumor-specific spectral patterns. Leave-one-patient-out cross validation of this algorithm in positive- and negative-ion modes showed accuracies in HNSCC diagnosis of 90.48% and 95.35%, respectively. In intraoperative specimens of HNSCC, this algorithm precisely defined the borders of the cancerous regions; these corresponded with those determined by examining histologic sections. The procedure took approximately 5 min.ConclusionThis diagnostic system, based on machine learning, enables accurate discrimination of cancerous regions and has the potential to provide rapid intraoperative assessment of HNSCC margins.



http://ift.tt/2i2J8st

Targeting and suppression of HER3-positive breast cancer by T lymphocytes expressing a heregulin chimeric antigen receptor

Abstract

Chimeric antigen receptor-modulated T lymphocytes (CAR-T) have emerged as a powerful tool for arousing anticancer immunity. Endogenous ligands for tumor antigen may outperform single-chain variable fragments to serve as a component of CARs with high cancer recognition efficacy and minimized immunogenicity. As heterodimerization and signaling partners for human epidermal growth factor receptor 2 (HER2), HER3/HER4 has been implicated in tumorigenic signaling and therapeutic resistance of breast cancer. In this study, we engineered T cells with a CAR consisting of the extracellular domain of heregulin-1β (HRG1β) that is a natural ligand for HER3/HER4, and evaluated the specific cytotoxicity of these CAR-T cells in cultured HER3 positive breast cancer cells and xenograft tumors. Our results showed that HRG1β-CAR was successfully constructed, and T cells were transduced at a rate of 50%. The CAR-T cells specifically recognized and killed HER3-overexpressing breast cancer cells SK-BR-3 and BT-474 in vitro, and displayed potent tumoricidal effect on SK-BR-3 xenograft tumor models. Our results suggest that HRG1β-based CAR-T cells effectively suppress breast cancer driven by HER family receptors, and may provide a novel strategy to overcome cancer resistance to HER2-targeted therapy.

http://ift.tt/2yOJf54

Vocal fold augmentation under local anesthesia using autologous fascia

Abstract

Vocal fold augmentation by injection of autologous fascia has been used since the 1990s with excellent safety record in 500 operations done under general anaesthesia. It is safe from risks arising from allergic or other foreign body adverse reactions. Fascia provides long-term augmentation and remains stable 3-10 years after injection.

Vocal fold augmentation under local anaesthesia is excellent alternative for those unfit for general anaesthesia, providing aid to fragile and weak persons with vocal fold paralysis. However, all of available synthetic materials resorb within 6-24 months.

Fascia injection under local anaesthesia provides the possibility for a long-term vocal fold medialization while avoiding risk of general anaesthesia. Fascia lata harvesting and processing is easily done (as shown in video) followed by injection into the vocal fold. The whole procedure is done under local anaesthesia. Procedure offers long-term vocal fold medialization, fine tuning the amount of the medialization by immediate feedback from the patient's voice. Operation time is one hour.

This article is protected by copyright. All rights reserved.

http://ift.tt/2zymHCQ

Book Review—Diagnostic pathology: thoracic, 2nd edition

http://ift.tt/2AzMqLm

Treatment of chronic spontaneous urticaria: Immunomodulatory approaches

Publication date: Available online 9 November 2017
Source:Clinical Immunology
Author(s): de Montjoye Laurence, Herman Anne, Nicolas Jean-François, Baeck Marie
This paper summarizes and reviews the mechanisms of action and data concerning efficacy of recommended treatments as well as other treatments that have been tested, independently of the outcomes, in the management of chronic spontaneous urticaria. Due to the central role of mast cells and histamine in the pathophysiology of this disease, H1-antihistamines remain the first-line treatment. However, current knowledge about this complex disease, also recognizes an important role for T lymphocytes, B lymphocytes, and autoantibodies. Implications of these others mediators thus provide further targets for treatment. Indeed, agents previously used to treat other autoimmune and inflammatory diseases, have demonstrated efficacy in chronic spontaneous urticaria and are therefore potential therapeutic alternatives for antihistamine unresponsive patients.



http://ift.tt/2zzbNfW

mTOR inhibitor rapamycin induce polymorphonuclear myeloid-derived suppressor cells mobilization and function in protecting against acute graft-versus-host disease after bone marrow transplantation

Publication date: Available online 10 November 2017
Source:Clinical Immunology
Author(s): Yu Lin, Binsheng Wang, Wei Shan, Yamin Tan, Jingjing Feng, Lin Xu, Limengmeng Wang, Biqing Han, Mingming Zhang, Jian Yu, Xiaohong Yu, He Huang
The mammalian target of rapamycin (mTOR) inhibitor rapamycin (RAPA) has been shown to be an effective immunosuppressor in the management of acute graft-versus-host disease (aGVHD) after bone marrow transplantation. Myeloid-derived suppressor cells (MDSCs) also have a protective effect in aGVHD regulation. However, the relationship between RAPA and MDSCs in aGVHD models is unclear. Meanwhile, the effect of RAPA on different subgroups of MDSCs is also less well described. In this study, we demonstrate that in vivo administration of RAPA results in the expansion and functional enhancement of polymorphonuclear MDSCs (PMN-MDSCs) in a murine model of aGVHD. RAPA treatment can enhance the suppressive function of PMN-MDSCs via up-regulation of arginase1 (Arg1) and induced nitric oxide synthase (iNOS) at later time points. Moreover, RAPA can also induce a strong immunosuppressive function in PMN-MDSCs from murine bone marrow in vitro, but has a contrary effect on monocytic MDSCs (M-MDSCs). We found that RAPA-treated PMN-MDSCs can restrain the differentiation of Th1/Th2 cells and promote induction of regulatory T cells in in vitro studies.



http://ift.tt/2yr0AwQ

Tailored resections in oral and oropharyngeal cancer using narrow band imaging

Publication date: Available online 10 November 2017
Source:American Journal of Otolaryngology
Author(s): Giancarlo Tirelli, Marco Piovesana, Alberto Vito Marcuzzo, Annalisa Gatto, Matteo Biasotto, Rossana Bussani, Lorenzo Zandonà, Fabiola Giudici, Francesca Boscolo Nata
PurposeIn a previous pilot study we observed that intra-operative narrow-band imaging (NBI) helps achieve clear superficial resection margins. The aim of this study was to verify if the use of intra-operative NBI can help to obtain tailored resections and if it is influenced by the lesion site, aspects not investigated in our previous study.Materials and methodsThe resection margins of 39 oral and 22 oropharyngeal squamous cell carcinomas were first set at 1.5cm from the macroscopic lesion boundary (white light, WL, tattoo). Then, the superficial tumor extension was more precisely defined with NBI, giving rise to three possible situations: NBI tattoo larger than the WL tattoo, NBI tattoo coinciding with the WL tattoo, or NBI tattoo smaller than the WL tattoo. For each of these situations the space comprised between the NBI and WL tattoos was defined "NBI positive", "NBI null", and "NBI negative", respectively. Resections were performed following the outer tattoo. The number of clear superficial resection margins, and the pathological response on the "NBI-positive" and the "NBI-negative" areas were recorded.ResultsWe obtained 80.3% negative superficial resection margins. NBI provided a more precise definition of superficial tumor extension in 43 patients. Sensitivity, specificity, positive and negative predictive values were 94.4%, 64%, 79.1% and 88.9%, respectively; a test of proportions demonstrated they were not influenced by tumor site.ConclusionsNBI could allow for real-time definition of superficial tumor extension with possible tailored resections and fewer positive superficial resection margins; it is not influenced by tumor site.



http://ift.tt/2AxIdaS

Reconstruction of preauricular soft tissue defects using a superiorly based rotation advancement scalp flap - A novel approach to the surgical treatment of preauricular sinuses

Publication date: Available online 10 November 2017
Source:American Journal of Otolaryngology
Author(s): Bernard Tan, Lee Tee Sin, Ian Loh




http://ift.tt/2jjgmab

A Cross-sectional Epidemiological Study of Hidradenitis Suppurativa in an Irish Population

Abstract

Background

Hidradenitis suppurativa (HS), a chronic inflammatory disease that affects apocrine gland–bearing skin, has a significant impact on patient quality of life. Estimates of the epidemiologic prevalence of HS are highly variable, and clinical data on disease characteristics and patient burden of disease remain limited.

Objective

The primary objective of this study was to determine the number of patients with HS attending dermatology clinics in a hospital setting in Ireland (within a 6-month time period). Secondary objectives included the assessment of disease characteristics and the collection of patient responses on disease burden and work productivity.

Methods

This was an epidemiologic, non-interventional, cross-sectional study across 4 dermatology clinics in Ireland over a 6-month time period. The disease prevalence was estimated by calculating the percentage of total patients with a diagnosis of HS (the primary population) across the selected sites. Secondary analyses were performed using the full analysis set, which consisted of eligible adults (≥18 years of age) from the primary population who provided informed consent. Data from these analyses are presented as descriptive summary statistics, with the use of an analysis of covariance for continuous endpoints.

Results

The prevalence of HS across the 4 selected sites was estimated at 1.4% (95% CI, 1.24–1.62). One hundred fifty eligible patients comprised the full analysis set. The majority of participants were white (95%), female (70%), cigarette smokers (56%), and overweight or obese (body mass index ≥25 kg/m², 82%). Most patients presented with Hurley stage II (45%), and more than a third had a relative with HS (35%). Questionnaire responses revealed a profound impact on quality of life, including diminished work productivity and various psychological comorbidities.

Conclusion

This study offers insight into the clinical features and disease burden of hidradenitis suppurativa in an Irish population.

This article is protected by copyright. All rights reserved.

http://ift.tt/2jj5Akf

Milker's nodule:an occupational infection and threat to the immunocompromised

Abstract

Milker's nodule virus, also called paravaccinia virus is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5-15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker's nodules are self-limited in immunocompetent individuals and heal without scarring within 8 weeks.

Another member of the Parapoxvirus genus, the orf virus, is also transmitted from animals to humans by direct-contact. While complications are rare, hematopoietic stem cell transplant recipients are at risk of graft-versus-host disease, as the parapoxvirus may trigger these complications in immunocompromised individuals. In addition, paravaccinia may serve as the antigen source for the development of erythema multiforme.

The unique structure and replication process of viruses in the Poxvirus family, while includes the Parapoxvirus genus, have been a focus for treatment of infections and cancer. Manipulation of these viruses has demonstrated promising therapeutic possibilities as vectors for vaccines and oncologic therapy.

This article is protected by copyright. All rights reserved.

http://ift.tt/2hp3oau

Integration of dermoscopy and reflectance confocal microscopy for distinguishing melanomas from nevi of the breast area

Abstract

Background

Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathologic features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions in order to avoid unnecessary excisions.

Objectives

The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area.

Methods

Dermoscopic and confocal images from consecutive patients with at least 1 clinically and/or dermoscopically equivocal melanocytic skin lesion of the breast area were retrospectively evaluated. In this case-control study, only histopathologically-proven melanomas (cases) and nevi (controls) were included. Spearman's coefficients were first calculated to flag significant correlation; then univariate and multivariate logistic regression analysis were performed to assess which factors were independently associated with the histopathological diagnosis. Finally, a mixed dermoscopic/confocal score was created to distinguish nevi from melanomas on the breast area.

Results

The study population included 55 skin lesions of the breast area, 34 (61.8%) nevi and 21 (38.2%) melanomas. Among dermoscopic criteria, atypical network and irregular pigmentation resulted independently associated with melanoma diagnosis (OR: 11.1; 95%CI 1.0-119.9; P:.048 and OR: 6.5; 95%CI 1.1-37.5; P:.037, respectively). Furthermore, on RCM examination the presence of pagetoid cells was an independent positive predictor for melanoma (OR: 38.5; 95%CI 3.9-379.6; P:.002). The mixed score showed high levels of sensitivity and specificity, 95.2% and 82.4%, respectively, which were higher than dermoscopic and confocal evaluations alone.

Conclusion

The combined use of dermoscopy and confocal microscopy in the triage of pigmented lesions of the breast area may help in increasing the diagnostic accuracy and avoiding unnecessary excisions.

This article is protected by copyright. All rights reserved.

http://ift.tt/2jgwgCi

Micrognathia with temporomandibular joint ankylosis and obstructive sleep apnea treated with mandibular distraction osteogenesis using skeletal anchorage: a case report

Abstract

Background

We describe the case of a 16-year-old female patient with micrognathia, temporomandibular joint (TMJ) ankylosis, and obstructive sleep apnea, who was treated with mandibular distraction osteogenesis (DO) combined with sliding genioplasty, using skeletal anchorage.

Case presentation

We first performed interpositional arthroplasty, in which an interposition of fascia temporalis and surrounding fat tissue was inserted into the defect after bilateral condylectomy, increasing the maximum mouth opening from 5.0 to 32.0 mm. Subsequently, orthodontic treatment and advancement of the mandible were carried out by mandibular DO, using miniscrews and miniplates. Finally, sliding genioplasty was performed to bring the tip of the mandible forward. The total amount of mandibular advancement at the menton was 16.0 mm. An improved facial appearance and good occlusion were eventually achieved, and the apnea-hypopnea index decreased from 37.1 to 8.7. There was no obvious bone resorption or pain in the temporomandibular region, limited mouth opening (maximum mouth opening: 33.0 mm), myofascial pain or headache, downward rotation of the mandible, or lateral shift of mandibular position evident at 5 years and 6 months after mandibular DO.

Conclusion

Mandibular DO using skeletal anchorage with intermaxillary elastics is useful for preventing extrusion of the upper and lower anterior teeth, thereby preventing rotation of the mandible. In addition, mandibular DO combined with sliding genioplasty is effective at improving both dentofacial deformities and impaired respiratory function.

http://ift.tt/2AqwHNO

The influence of immediately loaded implant treatment in the atrophic edentulous maxilla on oral health related quality of life of edentulous patients: 3-year results of a prospective study

Abstract

Background

To evaluate oral health related quality of life (OHQoL) in edentulous patients treated with immediately loaded implants in the maxilla.

Methods

Fifty-one edentulous patients in two centers received six maxillary implants each were loaded within 24 h with provisional restoration. Definitive restoration was delivered 20–24 weeks later. OHQoL was evaluated preoperatively with the Oral Health Impact Profile 49 questionnaire (OHIP-49) and on five subsequent occasions. OHIP-49 includes seven domains representing functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap. A reduction in OHIP scores indicated an improved OHQoL.

Results

Forty-five patients reached the three-year follow up. OHQoL improved after treatment. A plateau of OHQoL improvement was observed at 12 months after surgery. The seven domains improved at different pace, 12 weeks to 12 months after treatment. OHIP showed continuously low scores with no significant changes at consecutive visits 12 months to three years after treatment. Dental status with removable prosthesis in the mandible had a negative impact on OHQoL prior to and during treatment, but did not affect OHQoL after permanent restoration was placed. Patients age or gender did not affect OHQoL.

Conclusions

Patients with edentulous maxilla who received prosthetic rehabilitation on immediately loaded implants experienced the highest improved OHQoL 12 months after implant installation. Quality of life related to oral health continued to be high after three years. Edentulous patients with atrophy of the maxilla experience an improved OHQoL after implant treatment with immediate loading protocol.

Trial registration

ClinicalTrials.gov Identifier NCT00711022.

http://ift.tt/2hZvy94

Reduziertes Blickfeld infolge benigner Neubildung am Oberlid

http://ift.tt/2zx4KED

Ancient colonization of marginal habitats. A comparative analysis of case studies from the Ancient World

Wiebke, B; Beck, D; Gerlach, I; Klein, T; Knitter, D; Kohlmeyer, K; Krause, J; ... Wulf-Rheidt, U; + view all Wiebke, B; Beck, D; Gerlach, I; Klein, T; Knitter, D; Kohlmeyer, K; Krause, J; Marzoli, D; Meister, J; Muller-Neuhof, B; Naeser, C; von Rummel, P; Sack, D; Schmid, SG; Schutt, B; Wulf-Rheidt, U; - view fewer (2016) Ancient colonization of marginal habitats. A comparative analysis of case studies from the Ancient World. eTopoi. Journal of Ancient Studies , 6 pp. 1-44. Green open access

http://ift.tt/2AzvSCY

Leadership in Inclusive Special Education: A Qualitative Exploration of the SENCO Role in Post-Primary Schools in Ireland

Fitzgerald, Johanna; (2017) Leadership in Inclusive Special Education: A Qualitative Exploration of the SENCO Role in Post-Primary Schools in Ireland. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2jiicYZ

Multiscale computing in the exascale era

Alowayyed, S; Groen, D; Coveney, PV; Hoekstra, AG; (2017) Multiscale computing in the exascale era. Journal of Computational Science , 22 pp. 15-25. 10.1016/j.jocs.2017.07.004 . Green open access

http://ift.tt/2AynTX1

Teaching and learning practices and reported experiences of teachers and students in high, middle and low ability maths classes.

Warrington, P; (2017) Teaching and learning practices and reported experiences of teachers and students in high, middle and low ability maths classes. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2jgiGPk

Exploring dissociative water adsorption on isoelectronically BN doped graphene using alchemical derivatives

Al-Hamdani, YS; Michaelides, A; von Lilienfeld, OA; (2017) Exploring dissociative water adsorption on isoelectronically BN doped graphene using alchemical derivatives. Journal of Chemical Physics , 147 (16) , Article 164113. 10.1063/1.4986314 .

http://ift.tt/2Azfti5

Reciprocal Teaching: An Exploration of its Effectiveness in Improving the Vocabulary and Reading Comprehension of Key Stage Two Pupils with and without English as an Additional Language

Relton, SK; (2017) Reciprocal Teaching: An Exploration of its Effectiveness in Improving the Vocabulary and Reading Comprehension of Key Stage Two Pupils with and without English as an Additional Language. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2jeNEY9

Nano- and Micro-Auxetic Plasmonic Materials

Valente, J; Plum, E; Youngs, IJ; Zheludev, NI; (2016) Nano- and Micro-Auxetic Plasmonic Materials. Advanced Materials , 28 (26) pp. 5176-5180. 10.1002/adma.201600088 . Green open access

http://ift.tt/2Axpts2

Educational psychologists and youth offending services: Working together to improve the educational outcomes of young offenders. An action research project.

Parnes, H; (2017) Educational psychologists and youth offending services: Working together to improve the educational outcomes of young offenders. An action research project. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2jihZoF

An evaluation of the effectiveness of the Local Early Autism Programme (LEAP)

Limbert, Elizabeth Mary; (2017) An evaluation of the effectiveness of the Local Early Autism Programme (LEAP). Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2AzfjY1

Fault-tolerance thresholds for the surface code with fabrication errors

Auger, JM; Anwar, H; Gimeno-Segovia, M; Stace, TM; Browne, DE; (2017) Fault-tolerance thresholds for the surface code with fabrication errors. Physical Review A , 96 (4) , Article 042316. 10.1103/PhysRevA.96.042316 . Green open access

http://ift.tt/2jgxQUA

Capturing the Voices of Looked-After Children via Computerised Assisted Self-Interviewing Technology: A Longitudinal Approach

Johnson, Emily; (2017) Capturing the Voices of Looked-After Children via Computerised Assisted Self-Interviewing Technology: A Longitudinal Approach. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2AyACJb

Straw poll: Painting is fluid but is it porous?

Rideal, L; (2017) Straw poll: Painting is fluid but is it porous? In: Hartshorne, I and Moloney, D and Quaife, M, (eds.) Teaching Painting: A Conference. Black Dog Publishing Ltd: London, UK.

http://ift.tt/2jfuRfn

How to raise 'hope' in young people from a moderate learning difficulties special school?

Cheong, Mei Yan; (2017) How to raise 'hope' in young people from a moderate learning difficulties special school? Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2Azf9jn

Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.

Fryer, TD; Ejaz, S; Jensen-Kondering, U; Williamson, DJ; Sitnikov, S; Sawiak, SJ; Aigbirhio, FI; ... Baron, J-C; + view all Fryer, TD; Ejaz, S; Jensen-Kondering, U; Williamson, DJ; Sitnikov, S; Sawiak, SJ; Aigbirhio, FI; Hong, YT; Baron, J-C; - view fewer (2017) Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies. PLoS One , 12 (11) , Article e0187087. 10.1371/journal.pone.0187087 . Green open access

http://ift.tt/2jfMYSs

Impact of constitutional polymorphisms in immune effector mechanisms on clinical response to rituximab therapy in patients with follicular lymphoma

Lowry, LM; (2017) Impact of constitutional polymorphisms in immune effector mechanisms on clinical response to rituximab therapy in patients with follicular lymphoma. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2AyAp8R

A configurational approach to vernacular domestic architecture: 'Traditional' Houses in Turkey, Japan and Britain

Uyar, G; Griffiths, S; (2017) A configurational approach to vernacular domestic architecture: 'Traditional' Houses in Turkey, Japan and Britain. In: Proceedings of the 11th Space Syntax Symposium. (pp. 32.1-32.16). International Space Syntax Symposia: Lisbon, Portugal. Green open access

http://ift.tt/2jewBoZ

Finite volume approximations of the Euler system with variable congestion

Degond, P; Minakowski, P; Navoret, L; Zatorska, E; (2017) Finite volume approximations of the Euler system with variable congestion. Computers and Fluids 10.1016/j.compfluid.2017.09.007 . (In press). Green open access

http://ift.tt/2AyAg5j

Gender and absentee slave-ownership in late eighteenth- and early nineteenth-century Britain

Young, Hannah Louise; (2017) Gender and absentee slave-ownership in late eighteenth- and early nineteenth-century Britain. Doctoral thesis , UCL (University College London).

http://ift.tt/2jihXNz

Thermal conductivity of thermoelectric material beta-Cu2Se: Implications on phonon thermal transport

Namsani, S; Auluck, S; Singh, JK; (2017) Thermal conductivity of thermoelectric material beta-Cu2Se: Implications on phonon thermal transport. AIP Applied Physics Letters , 111 (16) , Article 163903. 10.1063/1.4999405 . Green open access

http://ift.tt/2AyAb1v

Gyration Spun Polymeric Fibres for Antibacterial Applications

Xu, Zewen; (2017) Gyration Spun Polymeric Fibres for Antibacterial Applications. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2jfMYlq

Wip1 regulates blood-brain barrier function and neuro-inflammation induced by lipopolysaccharide via the sonic hedgehog signaling signaling pathway

Publication date: January 2018
Source:Molecular Immunology, Volume 93
Author(s): Hong Zhen, Lize Zhao, Zhangjun Ling, Li Kuo, Xiarui Xue, Jiaxiu Feng
The blood brain barrier (BBB) is a diffusion barrier that maintains the brain environment. Wip1 is a nuclear phosphatase induced by many factors and involved in various stresses, tumorigenesis, organismal aging, and neurogenesis. Wip1's role in BBB integrity has not been thoroughly investigated. The purpose of the present study was to investigate the effect and mechanism of Wip1 on lipopolysaccharide (LPS)-induced BBB dysfunction and inflammation in an in vitro BBB model. The in vitro BBB model was established by co-culturing human brain-microvascular endothelial cells and human astrocytes and then exposing them to 1μg/ml LPS for 6, 12, 18, 24, and 48h. Wip1 expression was significantly elevated by LPS treatment. Knockdown of Wip1 aggravated the increased permeability and decreased transepithelial electrical resistance, protein expression of ZO-1, and occludin induced by LPS. Wip1 silencing augmented the elevated inflammatory cytokines TNF-α, IL-1β, IL-12, and IL-6 of the BBB induced by LPS, whereas overexpression of Wip1 showed a contrary effect. Sonic hedgehog signaling (SHH) was activated by Wip1 overexpression and inhibited by Wip1 silencing. Additionally, activating or inhibiting the SHH pathway by purmorphamine or cyclopamine, respectively, abolished the Wip1-induced changes in transepithelial electrical resistance and permeability and inflammatory responses in the LPS-injured BBB model. Our results demonstrate that Wip1 may protect the BBB against LPS-induced integrity disruption and inflammatory response through the SHH signaling pathway.



http://ift.tt/2hnhARi

Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast

Abstract

Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms comprising 0.3–1.0% of all primary breast tumours. The majority of PTs are benign and generally well managed with surgery. However, malignant PTs, and occasionally borderline PTs, can behave in a clinically aggressive manner by metastasizing to distant organs. Although distant metastasis is rare, the prognosis of patients with metastasis is dismal as many are unresponsive to standard chemotherapy and the risk of death is high. In this study, we correlated clinicopathological parameters to survival outcomes in a cohort of patients diagnosed with malignant PTs in our institution. The study cohort comprised 83 cases of malignant PTs diagnosed at the Department of Anatomical Pathology, Singapore General Hospital from 1994 to 2015. Clinicopathological features and follow-up were obtained from hospital records. Metastasis-free survival (MFS) and overall survival (OS) were estimated with the Kaplan-Meier method and compared between groups using the log-rank test. Cox regression was carried out to identify factors predictive for metastasis. Mean and median age of patients was 48 years (range 21–71 years). Tumour size measured from 30 to 220 mm (mean 90 mm, median 77 mm). Follow-up data was available for 68 patients. Mean and median follow-up was 90 and 57 months, respectively, with a maximum of 291 months. Distant metastasis occurred in 16 out of 68 patients (23.5%). The most common site of metastasis was the lung. Malignant heterologous elements were observed in 16 (19.3%) cases. Individual clinicopathological parameters had no impact on outcome. On Kaplan-Meier analysis, women with large tumours and presence of malignant heterologous elements showed trends for poorer MFS (p = 0.217 and p = 0.566, respectively). However, the combination of large tumours (≥ 90 mm) containing malignant heterologous elements disclosed significantly worse MFS (p = 0.043) and a trend for poorer OS (p = 0.238). On multivariate analysis, large tumours harbouring malignant heterologous elements independently predicted metastasis (95% CI 1.041–12.517, HR 2.434, p = 0.049). Our study demonstrates that tumour size and presence of malignant heterologous elements predicted metastasis in malignant PTs. Further work needs to be done in determining if protein biomarkers and genomic aberrations are able to additionally refine metastatic risk and define therapeutic targets.

http://ift.tt/2zvldv7

Classification of eosinophilic disorders of the small and large intestine

Abstract

Eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic gastroenteritis and eosinophilic colitis, have been increasing in prevalence in Western countries in recent years. Eosinophils are normally scanty in the gastrointestinal tract, and increased numbers of eosinophils can denote pathology. Normal values for tissue eosinophils vary widely between different segments of the colon, thus location of the biopsy is critically important for the interpretation of findings. However, no standard diagnostic criteria have been proposed for the diagnosis of eosinophilic gastroenteritis or eosinophilic colitis. Gut eosinophilia encompasses entitites that are predominantly immunoglobulin E (IgE)-mediated, the primary EGIDs and those that are secondary and not IgE-mediated. A final diagnosis of eosinophilic gastrointestinal diseases requires careful pathological assessment, clinical correlation and exclusion of several differential diagnoses.

http://ift.tt/2hkaGsy

Shalfak Archaeological Mission (SAM): The 2017 field season

Naeser, C; Becker, P; Kossatz, K; Karrar, OKE; (2017) Shalfak Archaeological Mission (SAM): The 2017 field season. Journal of Egyptian Archaeology , 103 (In press).

http://ift.tt/2AqYPAt

A focused ultrasound treatment system for moving targets (part I): generic system design and in-silico first-stage evaluation

Schwenke, M; Strehlow, J; Demedts, D; Haase, S; Barrios Romero, D; Rothlübbers, S; von Dresky, C; ... Preusser, T; + view all Schwenke, M; Strehlow, J; Demedts, D; Haase, S; Barrios Romero, D; Rothlübbers, S; von Dresky, C; Zidowitz, S; Georgii, J; Mihcin, S; Bezzi, M; Tanner, C; Sat, G; Levy, Y; Jenne, J; Günther, M; Melzer, A; Preusser, T; - view fewer (2017) A focused ultrasound treatment system for moving targets (part I): generic system design and in-silico first-stage evaluation. Journal of Therapeutic Ultrasound , 5 (1) , Article 20. 10.1186/s40349-017-0098-7 . Green open access

http://ift.tt/2hZfR1t

Constructing Participatory Environments: a Behavioural Model for Design

Spyropoulos, Theodore; (2017) Constructing Participatory Environments: a Behavioural Model for Design. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2AqrVzD

Help-seeking behaviours, opportunistic treatment and psychological implications of adolescent acne: cross-sectional studies in schools and hospital outpatient departments in the UK

Desai, KP; Martyn-Simmons, C; Viner, R; Segal, T; (2017) Help-seeking behaviours, opportunistic treatment and psychological implications of adolescent acne: cross-sectional studies in schools and hospital outpatient departments in the UK. BMJ Open , 7 (9) , Article e016964. 10.1136/bmjopen-2017-016964 . Green open access

http://ift.tt/2hZBFdF

Longitudinal analysis framework of DWI data for reconstructing structural brain networks with application to multiple sclerosis

Charalambous, T; Prados Carrasco, F; Tur Gomez, C; Kanber, B; Ourselin, S; Chard, D; Clayden, JD; ... Toosy, A; + view all Charalambous, T; Prados Carrasco, F; Tur Gomez, C; Kanber, B; Ourselin, S; Chard, D; Clayden, JD; Wheeler-Kingshott, CAM; Thompson, AJ; Toosy, A; - view fewer (2017) Longitudinal analysis framework of DWI data for reconstructing structural brain networks with application to multiple sclerosis. In: (Proceedings) MICCAI: International Conference on Medical Image Computing and Computer-Assisted Intervention - Computational Diffusion MRI, MICCAI Workshop. Springer: Switzerland, Cham. (In press).

http://ift.tt/2AqTnxf

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers

Stefan, CJ; Trimble, WS; Grinstein, S; Drin, G; Reinisch, K; De Camilli, P; Cohen, S; ... McBride, HM; + view all Stefan, CJ; Trimble, WS; Grinstein, S; Drin, G; Reinisch, K; De Camilli, P; Cohen, S; Valm, AM; Lippincott-Schwartz, J; Levine, TP; Iaea, DB; Maxfield, FR; Futter, CE; Eden, ER; Judith, D; van Vliet, AR; Agostinis, P; Tooze, SA; Sugiura, A; McBride, HM; - view fewer (2017) Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC Biology , 15 (1) , Article 102. 10.1186/s12915-017-0432-0 . Green open access

http://ift.tt/2hZBwH9

The role of the transcription factor Gli3 and Hedgehog signalling in fetal B cell and thymocyte development

Solanki, ASN; (2017) The role of the transcription factor Gli3 and Hedgehog signalling in fetal B cell and thymocyte development. Doctoral thesis , UCL (University College London).

http://ift.tt/2AqYCxb

Towards a unifying theory of generalization

Schulz, Eric; (2017) Towards a unifying theory of generalization. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2i1ut0G

Methods used to address fidelity of receipt in health intervention research: a citation analysis and systematic review

Rixon, L; Baron, J; McGale, N; Lorencatto, F; Francis, J; Davies, A; (2016) Methods used to address fidelity of receipt in health intervention research: a citation analysis and systematic review. BMC Health Services Research , 16 (1) , Article 663. 10.1186/s12913-016-1904-6 . Green open access

http://ift.tt/2AqYyNX

Turán problems in graphs and hypergraphs

Sanitt, Adam; (2017) Turán problems in graphs and hypergraphs. Doctoral thesis , UCL (University College London). Green open access

http://ift.tt/2i0HwPC

STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis post-transcriptionally and is essential for lung myofibroblast differentiation

Papaioannou, I; Xu, S; Denton, CP; Abraham, D; Ponticos, M; (2017) STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis post-transcriptionally and is essential for lung myofibroblast differentiation. Molecular Biology of the Cell (In press). Green open access

http://ift.tt/2ArEScF

Regulation of TNFR1 signalling by LUBAC-dependent and -associated proteins

Reichert, Matthias; (2017) Regulation of TNFR1 signalling by LUBAC-dependent and -associated proteins. Doctoral thesis , UCL (University College London).

http://ift.tt/2i0BjmT

Association between Systemic Lupus Erythematosus and Periodontitis A Systematic Review And Meta-Analysis

Rutter-Locher, Z; Smith, TO; Giles, I; Sofat, N; (2017) Association between Systemic Lupus Erythematosus and Periodontitis A Systematic Review And Meta-Analysis. Frontiers in Immunology , 8 , Article 1295. 10.3389/fimmu.2017.01295 . Green open access

http://ift.tt/2AracIk

A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2

Meera, P; Pulst, S; Otis, T; (2017) A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2. eLife , 6 , Article e26377. 10.7554/eLife.26377.001 . Green open access

http://ift.tt/2hZARFF

Heavy Ion Results from ATLAS

Jia, J; Aaboud, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; ... Zwalinski, L; + view all Jia, J; Aaboud, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Agatonovic-Jovin, T; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahlen, SP; Ahmadov, F; Aielli, G; Akatsuka, S; Akerstedt, H; Akesson, TPA; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Verzini, MJA; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, SP; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, M; Gonzalez, BA; Piqueras, DA; Alviggi, MG; Amadio, BT; Coutinho, YA; Amelung, C; Amidei, D; Dos Santos, SPA; Amorim, A; Amoroso, S; Amundsen, G; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Anjos, N; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, DJ; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Ferraz, VA; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, AJ; Armitage, LJ; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagnaia, P; Bahrasemani, H; Baines, JT; Bajic, M; Baker, OK; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Banas, E; Banerjee, S; Bannoura, AAE; Barak, L; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barklow, T; Barlow, N; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Navarro, LB; Barreiro, F; da Costa, JBG; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, R; Beck, HP; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, AJ; Beddall, A; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bemlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertram, IA; Bertsche, C; Bertsche, D; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Betancourt, C; Bethani, A; Bethke, S; Bevan, AJ; Beyer, J; Bianchi, RM; Bianco, M; Biebel, O; Biedermann, D; Bielski, R; Biesuz, NV; Biglietti, M; De Mendizabal, JB; Billoud, TRV; Bilokon, H; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, DM; Black, CW; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blum, W; Blumenschein, U; Blunier, S; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Bock, C; Boehler, M; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Sola, JDB; Boudreau, J; Bouffard, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; As, KB; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Briglin, DL; Bristow, TM; Britton, D; Britzger, D; Brochu, FM; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brosamer, J; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, E; Bugge, MK; Bulekov, O; Bullock, D; Burch, TJ; Burckhart, H; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Busato, E; Buscher, D; Buscher, V; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Urban, SC; Caforio, D; Cairo, VM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Lopez, SC; Calvet, D; Calvet, S; Calvet, TP; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Bret, MC; Cantero, J; Cao, T; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Carvalho, J; Casadei, D; Casado, MP; Casolino, M; Casper, DW; Castelijn, R; Gimenez, VC; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Alberich, LC; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Cheatham, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, H; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; El Moursli, RC; Chernyatin, V; Cheu, E; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Christodoulou, V; Chromek-Burckhart, D; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Ciftci, AK; Cinca, D; Cindro, V; Cioara, IA; Ciocca, C; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Ciubancan, M; Clark, A; Clark, BL; Clark, MR; Clark, PJ; Clarke, RN; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Colombo, T; Muino, PC; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conti, G; Conventi, F; Cooke, M; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corriveau, F; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cribbs, WA; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Cummings, J; Curatolo, M; Cuth, J; Czirr, H; Czodrowski, P; D'amen, G; D'Auria, S; D'Onofrio, M; De Sousa, MJDCS; Da Via, C; Dabrowski, W; Dado, T; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Dandoy, JR; Dang, NP; Daniells, AC; Dann, NS; Danninger, M; Hoffmann, MD; Dao, V; Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davies, M; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Dearnaley, WJ; Debbe, R; Debenedetti, C; Dedovich, DV; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Del Prete, T; Delgove, D; Deliot, F; Delitzsch, CM; Dell'Acqua, A; Dell'Asta, L; Dell'Orso, M; Della Pieta, M; della Volpe, D; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Demilly, A; Denisov, SP; Denysiuk, D; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Diaz, MA; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, JI; do Vale, MAB; Dobos, D; Dobre, M; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dris, M; Du, Y; Duarte-Campderros, J; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duhrssen, M; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Yildiz, HD; Duren, M; Durglishvili, A; Duschinger, D; Dutta, B; Dyndal, M; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Elles, S; Ellinghaus, F; Elliot, AA; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Endner, OC; Ennis, JS; Erdmann, J; Ereditato, A; Ernis, G; Ernst, M; Errede, S; Escalier, M; Escobar, C; Esposito, B; Pastor, OE; Etienvre, AI; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Facini, G; Fakhrutdinov, RM; Falciano, S; Falla, RJ; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, C; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, H; Fenton, MJ; Fenyuk, AB; Feremenga, L; Martinez, PF; Perez, SF; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filipuzzi, M; Filthaut, F; Fincke-Keeler, M; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, A; Fischer, C; Fischer, J; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Castillo, LRF; Flowerdew, MJ; Foerster, FA; Forcolin, GT; Formica, A; Forti, A; Foster, AG; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Franchino, S; Francis, D; Franconi, L; Franklin, M; Frate, M; Fraternali, M; Freeborn, D; Fressard-Batraneanu, SM; Freund, B; Froidevaux, D; Frost, JA; Fukunaga, C; Torregrosa, EF; Fusayasu, T; Fuster, J; Gabaldon, C; Gabizon, O; Gabrielli, A; Gabrielli, A; Gach, GP; Gadatsch, S; Gadomski, S; Gagliardi, G; Gagnon, LG; Galea, C; Galhardo, B; Gallas, EJ; Gallop, BJ; Gallus, P; Galster, G; Gan, KK; Ganguly, S; Gao, Y; Gao, YS; Walls, FMG; Garcia, C; Navarro, JEG; Garcia-Sciveres, M; Gardner, RW; Garelli, N; Garonne, V; Bravo, AG; Gasnikova, K; Gatti, C; Gaudiello, A; Gaudio, G; Gavrilenko, IL; Gay, C; Gaycken, G; Gazis, EN; Gee, CNP; Geisen, J; Geisen, M; Geisler, MP; Gellerstedt, K; Gemme, C; Genest, MH; Geng, C; Gentile, S; Gentsos, C; George, S; Gerbaudo, D; Gershon, A; Ghasemi, S; Ghneimat, M; Giacobbe, B; Giagu, S; Giannetti, P; Gibson, SM; Gignac, M; Gilchriese, M; Gillberg, D; Gilles, G; Gingrich, DM; Giokaris, N; Giordani, MP; Giorgi, FM; Giraud, PF; Giromini, P; Giugni, D; Giuli, F; Giuliani, C; Giulini, M; Gjelsten, BK; Gkaitatzis, S; Gkialas, I; Gkougkousis, EL; Gkountoumis, P; Gladilin, LK; Glasman, C; Glatzer, J; Glaysher, PCF; Glazov, A; Goblirsch-Kolb, M; Godlewski, J; Goldfarb, S; Golling, T; Golubkov, D; Gomes, A; Goncalo, R; Gama, RG; Da Costa, JGPF; Gonella, G; Gonella, L; Gongadze, A; de la Hoz, SG; Gonzalez-Sevilla, S; Goossens, L; Gorbounov, PA; Gordon, HA; Gorelov, I; Gorini, B; Gorini, E; Gorisek, A; Goshaw, AT; Gossling, C; Gostkin, MI; Gottardo, CA; Goudet, CR; Goujdami, D; Goussiou, AG; Govender, N; Gozani, E; Graber, L; Grabowska-Bold, I; Gradin, POJ; Gramling, J; Gramstad, E; Grancagnolo, S; Gratchev, V; Gravila, PM; Gray, C; Gray, HM; Greenwood, ZD; Grefe, C; Gregersen, K; Gregor, IM; Grenier, P; Grevtsov, K; Griffiths, J; Grillo, AA; Grimm, K; Grinstein, S; Gris, P; Grivaz, J-F; Groh, S; Gross, E; Grosse-Knetter, J; Grossi, GC; Grout, ZJ; Grummer, A; Guan, L; Guan, W; Guenther, J; Guescini, F; Guest, D; Gueta, O; Gui, B; Guido, E; Guillemin, T; Guindon, S; Gul, U; Gumpert, C; Guo, J; Guo, W; Guo, Y; Gupta, R; Gupta, S; Gustavino, G; Gutierrez, P; Ortiz, NGG; Gutschow, C; Guyot, C; Guzik, MP; Gwenlan, C; Gwilliam, CB; Haas, A; Haber, C; Hadavand, HK; Haddad, N; Hadef, A; Hagebock, S; Hagihara, M; Hakobyan, H; Haleem, M; Haley, J; Halladjian, G; Hallewell, GD; Hamacher, K; Hamal, P; Hamano, K; Hamilton, A; Hamity, GN; Hamnett, PG; Han, L; Han, S; Hanagaki, K; Hanawa, K; Hance, M; Haney, B; Hanke, P; Hansen, JB; Hansen, JD; Hansen, MC; Hansen, PH; Hara, K; Hard, AS; Harenberg, T; Hariri, F; Harkusha, S; Harrington, RD; Harrison, PF; Hartjes, F; Hartmann, NM; Hasegawa, M; Hasegawa, Y; Hasib, A; Hassani, S; Haug, S; Hauser, R; Hauswald, L; Havener, LB; Havranek, M; Hawkes, CM; Hawkings, RJ; Hayakawa, D; Hayden, D; Hays, CP; Hays, JM; Hayward, HS; Haywood, SJ; Head, SJ; Heck, T; Hedberg, V; Heelan, L; Heidegger, KK; Heim, S; Heim, T; Heinemann, B; Heinrich, JJ; Heinrich, L; Heinz, C; Hejbal, J; Helary, L; Held, A; Hellman, S; Helsens, C; Henderson, RCW; Heng, Y; Henkelmann, S; Correia, AMH; Henrot-Versille, S; Herbert, GH; Herde, H; Herget, V; Jimenez, YH; Herten, G; Hertenberger, R; Hervas, L; Herwig, TC; Hesketh, GG; Hessey, NP; Hetherly, JW; Higashino, S; Higon-Rodriguez, E; Hill, E; Hill, JC; Hiller, KH; Hillier, SJ; Hils, M; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, MC; Hodgson, P; Hoecker, A; Hoeferkamp, MR; Hoenig, F; Hohn, D; Holmes, TR; Homann, M; Honda, S; Honda, T; Hong, TM; Hooberman, BH; Hopkins, WH; Horii, Y; Horton, AJ; Hostachy, J-Y; Hou, S; Hoummada, A; Howarth, J; Hoya, J; Hrabovsky, M; Hrdinka, J; Hristova, I; Hrivnac, J; Hryn'ova, T; Hrynevich, A; Hsu, PJ; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huffman, TB; Hughes, EW; Hughes, G; Huhtinen, M; Huo, P; Huseynov, N; Huston, J; Huth, J; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Idrissi, Z; Iengo, P; Igonkina, O; Iizawa, T; Ikegami, Y; Ikeno, M; Ilchenko, Y; Iliadis, D; Ilic, N; Introzzi, G; Ioannou, P; Iodice, M; Iordanidou, K; Ippolito, V; Isacson, MF; Ishijima, N; Ishino, M; Ishitsuka, M; Issever, C; Istin, S; Ito, F; Ponce, JMI; Iuppa, R; Iwasaki, H; Izen, JM; Izzo, V; Jabbar, S; Jackson, P; Jacobs, RM; Jain, V; Jakobi, KB; Jakobs, K; Jakobsen, S; Jakoubek, T; Jamin, DO; Jana, DK; Jansky, R; Janssen, J; Janus, M; Janus, PA; Jarlskog, G; Javadov, N; Javurek, T; Javurkova, M; Jeanneau, F; Jeanty, L; Jejelava, J; Jelinskas, A; Jenni, R; Jeske, C; Jezequel, S; Ji, H; Jia, J; Jiang, H; Jiang, Y; Jiang, Z; Jiggins, S; Pena, JJ; Jin, S; Jinaru, A; Jinnouchi, O; Jivan, H; Johansson, P; Johns, KA; Johnson, CA; Johnson, WJ; Jon-And, K; Jones, RWL; Jones, SD; Jones, S; Jones, TJ; Jongmanns, J; Jorge, PM; Jovicevic, J; Ju, X; Rozas, AJ; Kohler, MK; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kahn, SJ; Kaji, T; Kajomovitz, E; Kalderon, CW; Kaluza, A; Kama, S; Kamenshchikov, A; Kanaya, N; Kanjir, L; Kantserov, VA; Kanzaki, J; Kaplan, B; Kaplan, LS; Kar, D; Karakostas, K; Karastathis, N; Kareem, MJ; Karentzos, E; Karpov, SN; Karpova, ZM; Karthik, K; Kartvelishvili, V; Karyukhin, AN; Kasahara, K; Kashif, L; Kass, RD; Kastanas, A; Kataoka, Y; Kato, C; Katre, A; Katzy, J; Kawade, K; Kawagoe, K; Kawamoto, T; Kawamura, G; Kay, EF; Kazanin, VF; Keeler, R; Kehoe, R; Keller, JS; Kempster, JJ; Keoshkerian, H; Kepka, O; Kersevan, BP; Kersten, S; Keyes, RA; Khader, M; Khalil-zada, F; Khanov, A; Kharlamov, AG; Kharlamova, T; Khodinov, A; Khoo, TJ; Khovanskiy, V; Khramov, E; Khubua, J; Kido, S; Kilby, CR; Kim, HY; Kim, SH; Kim, YK; Kimura, N; Kind, OM; King, BT; Kirchmeier, D; Kirk, J; Kiryunin, AE; Kishimoto, T; Kisielewska, D; Kiuchi, K; Kivemyk, O; Kladiva, E; Klapdor-Kleingrothaus, T; Klein, MH; Klein, M; Klein, U; Kleinknecht, K; Klimek, P; Klimentov, A; Klingenberg, R; Klingl, T; Klioutchnikova, T; Kluge, E-E; Kluit, P; Kluth, S; Kneringer, E; Knoops, EBFG; Knue, A; Kobayashi, A; Kobayashi, D; Kobayashi, T; Kobel, M; Kocian, M; Kodys, P; Koffas, T; Koffeman, E; Kohler, NM; Koi, T; Kolb, M; Koletsou, I; Komar, AA; Komori, Y; Kondo, T; Kondrashova, N; Koneke, K; Konig, AC; Kono, T; Konoplich, R; Konstantinidis, N; Kopeliansky, R; Koperny, S; Kopp, AK; Korcyl, K; Kordas, K; Korn, A; Korol, AA; Korolkov, I; Korolkova, EV; Kortner, O; Kortner, S; Kosek, T; Kostyukhin, VV; Kotwal, A; Koulouris, A; Kourkoumeli-Charalampidi, A; Kourkoumelis, C; Kourlitis, E; Kouskoura, V; Kowalewska, AB; Kowalewski, R; Kowalski, TZ; Kozakai, C; Kozanecki, W; Kozhin, AS; Kramarenko, VA; Kramberger, G; Krasnopevtsev, D; Krasny, MW; Krasznahorkay, A; Krauss, D; Kremer, JA; Kretzschmar, J; Kreutzfeldt, K; Krieger, P; Krizka, K; Kroeninger, K; Kroha, H; Kroll, J; Kroll, J; Kroseberg, J; Krstic, J; Kruchonak, U; Kruger, H; Krumnack, N; Kruse, MC; Kubota, T; Kucuk, H; Kuday, S; Kuechler, JT; Kuehn, S; Kugel, A; Kuger, F; Kuhl, T; Kukhtin, V; Kukla, R; Kulchitsky, Y; Kuleshov, S; Kulinich, YP; Kuna, M; Kunigo, T; Kupco, A; Kuprash, O; Kurashige, H; Kurchaninov, LL; Kurochkin, YA; Kurth, MG; Kus, V; Kuwertz, ES; Kuze, M; Kvita, J; Kwan, T; Kyriazopoulos, D; La Rosa, A; Navarro, JLLR; La Rotonda, L; Lacasta, C; Lacava, F; Lacey, J; Lacker, H; Lacour, D; Ladygin, E; Lafaye, R; Laforge, B; Lagouri, T; Lai, S; Lammers, S; Lampl, W; Lancon, E; Landgraf, U; Landon, MPJ; Lanfermann, MC; Lang, VS; Lange, JC; Langenberg, RJ; Lankford, AJ; Lanni, F; Lantzsch, K; Lanza, A; Lapertosa, A; Laplace, S; Laporte, JF; Lari, T; Manghi, FL; Lassnig, M; Laurelli, P; Lavrijsen, W; Law, AT; Laycock, P; Lazovich, T; Lazzaroni, M; Le, B; Le Dortz, O; Le Guirriec, E; Le Quilleuc, EP; LeBlanc, M; LeCompte, T; Ledroit-Guillon, F; Lee, CA; Lee, GR; Lee, SC; Lee, L; Lefebvre, B; Lefebvre, G; Lefebvre, M; Legger, F; Leggett, C; Lehan, A; Miotto, GL; Lei, X; Leight, WA; Leite, MAL; Leitner, R; Lellouch, D; Lemmer, B; Leney, KJC; Lenz, T; Lenzi, B; Leone, R; Leone, S; Leonidopoulos, C; Lerner, G; Leroy, C; Lesage, AAJ; Lester, CG; Levchenko, M; Leveque, J; Levin, D; Levinson, LJ; Levy, M; Lewis, D; Leyton, M; Li, B; Li, C; Li, H; Li, L; Li, Q; Li, S; Li, X; Li, Y; Liang, Z; Liberti, B; Liblong, A; Lie, K; Liebal, J; Liebig, W; Limosani, A; Lin, SC; Lin, TH; Lindquist, BE; Lionti, AE; Lipeles, E; Lipniacka, A; Lisovyi, M; Liss, TM; Lister, A; Litke, AM; Liu, B; Liu, H; Liu, H; Liu, JKK; Liu, J; Liu, JB; Liu, K; Liu, L; Liu, M; Liu, YL; Liu, Y; Livan, M; Lleres, A; Merino, JL; Lloyd, SL; Lo, CY; Lo Sterzo, F; Lobodzinska, EM; Loch, P; Loebinger, FK; Loew, KM; Loginov, A; Lohse, T; Lohwasser, K; Lokajicek, M; Long, BA; Long, JD; Long, RE; Longo, L; Looper, KA; Lopez, JA; Mateos, DL; Paz, IL; Solis, AL; Lorenz, J; Martinez, NL; Losada, M; Losel, PJ; Lou, X; Lounis, A; Love, J; Love, PA; Lu, H; Lu, N; Lu, YJ; Lubatti, HJ; Luci, C; Lucotte, A; Luedtke, C; Luehring, F; Lukas, W; Luminari, L; Lundberg, O; Lund-Jensen, B; Luzi, PM; Lynn, D; Lysak, R; Lytken, E; Lyubushkin, V; Ma, H; Ma, LL; Ma, Y; Maccarrone, G; Macchiolo, A; Macdonald, CM; Macek, B; Miguens, JM; Madaffari, D; Madar, R; Mader, WF; Madsen, A; Maeda, J; Maeland, S; Maeno, T; Maevskiy, A; Magradze, E; Mahlstedt, J; Maiani, C; Maidantchik, C; Maier, AA; Maier, T; Maio, A; Majewski, S; Makida, Y; Makovec, N; Malaescu, B; Malecki, P; Maleev, VP; Malek, F; Mallik, U; Malon, D; Malone, C; Maltezos, S; Malyukov, S; Mamuzic, J; Mancini, G; Mandelli, L; Mandic, I; Maneira, J; de Andrade Filho, LM; Ramos, JM; Mann, A; Manousos, A; Mansoulie, B; Mansour, JD; Mantifel, R; Mantoani, M; Manzoni, S; Mapelli, L; Marceca, G; March, L; Marchese, L; Marchiori, G; Marcisovsky, M; Marjanovic, M; Marley, DE; Marroquim, F; Marsden, SP; Marshall, Z; Martensson, MUF; Marti-Garcia, S; Martin, CB; Martin, TA; Martin, VJ; Latour, BMD; Martinez, M; Outschoorn, VIM; Martin-Haugh, S; Martoiu, VS; Martyniuk, AC; Marzin, A; Masetti, L; Mashimo, T; Mashinistov, R; Masik, J; Maslennikov, AL; Massa, L; Mastrandrea, R; Mastroberardino, A; Masubuchi, T; Mattig, P; Maurer, J; Maxfield, SJ; Maximov, DA; Mazini, R; Maznas, I; Mazza, SM; Mc Fadden, NC; Mc Goldrick, G; Mc Kee, SP; McCarn, A; McCarthy, RL; McCarthy, TG; McClymont, LI; McDonald, BF; Mcfayden, JA; Mchedlidze, G; McMahon, SJ; McNamara, PC; McPherson, RA; Meehan, S; Megy, TJ; Mehlhase, S; Mehta, A; Meideck, T; Meier, K; Melrose, B; Melini, D; Garcia, BRM; Mellenthin, JD; Melo, M; Meloni, F; Menary, SB; Meng, L; Meng, XT; Mengarelli, A; Menke, S; Meoni, E; Mergelmeyer, S; Mermod, P; Merola, L; Meroni, C; Merritt, FS; Messina, A; Metcalfe, J; Mete, AS; Meyer, C; Meyer, J-P; Meyer, J; Theenhausen, HMZ; Miano, F; Middleton, RP; Miglioranzi, S; Mijovio, L; Mikenberg, G; Mikestikova, M; Mikuz, M; Milesi, M; Milic, A; Miller, DW; Mills, C; Milov, A; Milstead, DA; Minaenko, AA; Minami, Y; Minashvili, IA; Mincer, AI; Mindur, B; Mineev, M; Minegishi, Y; Ming, Y; Mir, LM; Mistry, KP; Mitani, T; Mitrevski, J; Mitsou, VA; Miucci, A; Miyagawa, PS; Mizukami, A; Mjornmark, JU; Mkrtchyan, T; Mlynarikova, M; Moa, T; Mochizuki, K; Mogg, P; Mohapatra, S; Molander, S; Moles-Valls, R; Monden, R; Mondragon, MC; Monig, K; Monk, J; Monnier, E; Montalbano, A; Berlingen, JM; Monticelli, F; Monzani, S; Moore, RW; Morange, N; Moreno, D; Llacer, MM; Morettini, P; Morgenstern, S; Mori, D; Mori, T; Morii, M; Morinaga, M; Morisbak, V; Morley, AK; Mornacchi, G; Morris, JD; Morvaj, L; Moschovakos, P; Mosidze, M; Moss, HJ; Moss, J; Motohashi, K; Mount, R; Mountricha, E; Moyse, EJW; Muanza, S; Mudd, RD; Mueller, F; Mueller, J; Mueller, RSP; Muenstelluann, D; Mullen, P; Mullier, GA; Sanchez, FJM; Murray, WJ; Musheghyan, H; Muskinja, M; Myagkov, AG; Myska, M; Nachman, BP; Nackenhorst, O; Nagai, K; Nagai, R; Nagano, K; Nagasaka, Y; Nagata, K; Nagel, M; Nagy, E; Nairz, AM; Nakahama, Y; Nakamura, K; Nakamura, T; Nakano, I; Garcia, RFN; Narayan, R; Villar, DIN; Naryshkin, I; Naumann, T; Navarro, G; Nayyar, R; Neal, HA; Nechaeva, PY; Neep, TJ; Negri, A; Negrini, M; Nektarijevic, S; Nellist, C; Nelson, A; Nelson, ME; Nemecek, S; Nemethy, P; Nessi, M; Neubauer, MS; Neumann, M; Newman, PR; Ng, TY; Manh, TN; Nickerson, RB; Nicolaidou, R; Nielsen, J; Nikolaenko, V; Nikolic-Audit, I; Nikolopoulos, K; Nilsen, JK; Nilsson, P; Ninomiya, Y; Nisati, A; Nishu, N; Nisius, R; Nobe, T; Noguchi, Y; Nomachi, M; Nomidis, I; Nomura, MA; Nooney, T; Nordberg, M; Norjoharuddeen, N; Novgorodova, O; Nowak, S; Nozaki, M; Nozka, L; Ntekas, K; Nurse, E; Nuti, F; O'connor, K; O'Neill, DC; O'Rourke, AA; O'Shea, V; Oakharn, FG; Oberlack, H; Obermann, T; Ocariz, J; Ochi, A; Ochoa, I; Ochoa-Ricoux, JP; Oda, S; Odaka, S; Ogren, H; Oh, A; Oh, SH; Ohm, CC; Ohman, H; Oide, H; Okawa, H; Okumura, Y; Okuyama, T; Olariu, A; Seabra, LFO; Pino, SAO; Damazio, DO; Olszewski, A; Olszowska, J; Onofre, A; Onogi, K; Onyisi, PUE; Oreglia, MJ; Oren, Y; Orestano, D; Orlando, N; Orr, ORS; Osculati, B; Ospanov, R; Otero y Garzon, G; Otono, H; Ouchrif, M; Ould-Saada, F; Ouraou, A; Oussoren, KP; Ouyang, Q; Owen, M; Owen, RE; Ozcan, VE; Ozturk, N; Pachal, K; Pages, AP; Rodriguez, LP; Aranda, CP; Griso, SP; Paganini, M; Paige, F; Palacino, G; Palazzo, S; Palestini, S; Palka, M; Pallin, D; St Panagiotopoulou, E; Panagoulias, I; Pandini, CE; Vazquez, JGP; Pani, P; Panitkin, S; Pantea, D; Paolozzi, L; Papadopoulou, TD; Papageorgiou, K; Paramonov, A; Hernandez, DP; Parker, AJ; Parker, MA; Parker, KA; Parodi, F; Parsons, JA; Parzefall, U; Pascuzzi, VR; Pasner, JM; Pasqualucci, E; Passaggio, S; Pastore, F; Pataraia, S; Pater, JR; Pauly, T; Pearson, B; Lopez, SP; Pedro, R; Peleganchuk, SV; Penc, O; Peng, C; Peng, H; Penwell, J; Peralva, BS; Perego, MM; Perepelitsa, DV; Perini, L; Pernegger, H; Perrella, S; Peschke, R; Peshekhonov, VD; Peters, K; Peters, RFY; Petersen, BA; Petersen, TC; Petit, E; Petridis, A; Petridou, C; Petroff, P; Petrolo, E; Petrov, M; Petrucci, F; Pettersson, NE; Peyaud, A; Pezoa, R; Phillips, FH; Phillips, PW; Piacquadio, G; Pianori, E; Picazio, A; Piccaro, E; Pickering, MA; Piegaia, R; Pilcher, JE; Pilkington, AD; Pin, AWJ; Pinamonti, M; Pinfold, JL; Pirumov, H; Pitt, M; Plazak, L; Pleier, M-A; Pleskot, V; Plotnikova, E; Pluth, D; Podberezko, P; Poettgen, R; Poggi, R; Poggioli, L; Poh, D; Polesello, G; Poley, A; Policicchio, A; Polifka, R; Polini, A; Pollard, CS; Polychronakos, V; Pommes, K; Ponomarenko, D; Pontecorvo, L; Pope, BG; Popeneciu, GA; Poppleton, A; Pospisil, S; Potamianos, K; Potrap, IN; Potter, CJ; Potter, CT; Poulard, G; Poulsen, T; Poveda, J; Astigarraga, MEP; Pralavorio, P; Pranko, A; Prell, S; Price, D; Price, LE; Primavera, M; Prince, S; Proklova, N; Prokofiev, K; Prokoshin, F; Protopopescu, S; Proudfoot, J; Przybycien, M; Puri, A; Puzo, P; Qian, J; Qin, G; Qin, Y; Quadt, A; Quayle, WB; Queitsch-Maitland, M; Quilty, D; Raddum, S; Radeka, V; Radescu, V; Radhakrishnan, SK; Radloff, P; Rados, P; Ragusa, F; Rahal, G; Raine, JA; Rajagopalan, S; Rangel-Smith, C; Rashid, T; Raspopov, S; Ratti, MG; Rauch, DM; Rauscher, F; Rave, S; Ravinovich, I; Rawling, JH; Raymond, M; Read, AL; Readioff, NP; Reale, M; Rebuzzi, DM; Redelbach, A; Redlinger, G; Reece, R; Reed, RG; Reeves, K; Rehnisch, L; Reichert, J; Reiss, A; Rembser, C; Ren, H; Rescigno, M; Resconi, S; Resseguie, ED; Rettie, S; Reynolds, E; Rezanova, OL; Reznicek, P; Rezvani, R; Richter, R; Richter, S; Richter-Was, E; Ricken, O; Ridel, M; Rieck, R; Riegel, CJ; Rieger, J; Rifki, A; Rijssenbeek, M; Rimoldi, A; Rimoldi, M; Rinaldi, L; Ripellino, G; Ristio, B; Ritsch, E; Riu, I; Rizatdinova, F; Rizvi, E; Rizzi, C; Roberts, RT; Robertson, SH; Robichaud-Veronneau, A; Robinson, D; Robinson, JEM; Robson, A; Rocco, E; Roda, C; Rodina, Y; Bosca, SR; Perez, AR; Rodriguez, DR; Roe, S; Rogan, CS; Rohne, O; Roloff, J; Romaniouk, A; Romano, M; Saez, SMR; Adam, ER; Rompotis, N; Ronzani, M; Roos, L; Rosati, S; Rosbach, K; Rose, P; Rosien, N-A; Rossi, E; Rossi, LP; Rosten, JHN; Rosten, R; Rotaru, M; Roth, I; Rothberg, J; Rousseau, D; Rozanov, A; Rozen, Y; Ruan, X; Rubbo, F; Ruhr, F; Ruiz-Martinez, A; Rurikova, Z; Rusakovich, NA; Russell, HL; Rutherfoord, JP; Ruthmann, N; Ryabov, YF; Rybar, M; Rybkin, G; Ryu, S; Ryzhov, A; Rzehorz, GF; Saavedra, AF; Sabato, G; Sacerdoti, S; Sadrozinski, HF-W; Sadykov, R; Tehrani, FS; Saha, R; Sahinsoy, M; Saimpert, M; Saito, M; Saito, T; Sakamoto, H; Sakurai, Y; Salamanna, G; Loyola, JES; Salek, D; De Bruin, PHS; Salihagic, D; Salnikov, A; Salt, J; Salvatore, D; Salvatore, F; Salvucci, A; Salzburger, A; Sammel, D; Sampsonidis, D; Sampsonidou, D; Sanchez, J; Martinez, VS; Pineda, AS; Sandaker, H; Sandbach, RL; Sander, CO; Sandhoff, M; Sandoval, C; Sankey, DPC; Sannino, M; Sansoni, A; Santoni, C; Santonico, R; Santos, H; Castillo, IS; Sapronov, A; Saraiva, JG; Sarrazin, B; Sasaki, O; Sato, K; Sauvan, E; Savage, G; Savard, P; Savic, N; Sawyer, C; Sawyer, L; Saxon, J; Sbarra, C; Sbrizzi, A; Scanlon, T; Scannicchio, DA; Scarcella, M; Scarfone, V; Schaarschmidt, J; Schacht, P; Schachtner, BM; Schaefer, D; Schaefer, L; Schaefer, R; Schaeffer, J; Schaepe, S; Schaetzel, S; Schafer, U; Schaffer, AC; Schaile, D; Schamberger, RD; Scharf, V; Schegelsky, VA; Scheirich, D; Schernau, M; Schiavi, C; Schier, S; Schildgen, LK; Schillo, C; Schioppa, M; Schlenker, S; Schmidt-Sommerfeld, KR; Schmieden, K; Schmitt, C; Schmitt, S; Schmitz, S; Schnoor, U; Schoeffel, L; Schoening, A; Schoenrock, BD; Schopf, E; Schott, M; Schouwenberg, JFP; Schovancova, J; Schramm, S; Schuh, N; Schulte, A; Schultens, MJ; Schultz-Coulon, H-C; Schulz, H; Schumacher, M; Schumm, BA; Schune, P; Schwartzman, A; Schwarz, TA; Schweiger, H; Schwemling, P; Schwienhorst, R; Schwindling, J; Sciandra, A; Sciolla, G; Scuri, F; Scutti, F; Searcy, J; Seema, P; Seidel, SC; Seiden, A; Seixas, JM; Sekhniaidze, G; Sekhon, K; Sekula, SJ; Semprini-Cesari, N; Senkin, S; Serfon, C; Serin, L; Serkin, L; Sessa, M; Seuster, R; Severini, H; Sfiligoj, T; Sforza, F; Sfyrla, A; Shabalina, E; Shaikh, NW; Shan, LY; Shang, R; Shank, JT; Shapiro, M; Shatalov, PB; Shaw, K; Shaw, SM; Shcherbakova, A; Shehu, CY; Shen, Y; Sherwood, P; Shi, L; Shimizu, S; Shimmin, CO; Shimojima, M; Shipsey, IPJ; Shirabe, S; Shiyakova, M; Shlomi, J; Shmeleva, A; Saadi, DS; Shochet, MJ; Shojaii, S; Shope, DR; Shrestha, S; Shulga, E; Shupe, MA; Sicho, P; Sickles, AM; Sidebo, PE; Haddad, ES; Sidiropoulou, O; Sidoti, A; Siegert, F; Sijacki, D; Silva, J; Silverstein, SB; Simak, V; Simic, L; Simion, S; Simioni, E; Simmons, B; Simon, M; Sinervo, P; Sinev, NB; Sioli, M; Siragusa, G; Siral, I; Sivoklokov, SY; Sjolin, J; Skinner, MB; Skubic, P; Slater, M; Slavicek, T; Slawinska, M; Sliwa, K; Slovak, R; Smakhtin, V; Smart, BH; Smiesko, J; Smirnov, N; Smirnov, SY; Smirnov, Y; Smirnova, LN; Smirnova, O; Smith, JW; Smith, MNK; Smith, RW; Smizanska, M; Smolek, K; Snesarev, AA; Snyder, IM; Snyder, S; Sobie, R; Socher, F; Soffer, A; Soh, DA; Sokhrannyi, G; Sanchez, CAS; Solar, M; Soldatov, EY; Soldevila, U; Solodkov, AA; Soloshenko, A; Solovyanov, OV; Solovyev, V; Sommer, P; Son, H; Sopczak, A; Sosa, D; Sotiropoulou, CL; Soualah, R; Soukharev, AM; South, D; Sowden, BC; Spagnolo, S; Spalla, M; Spangenberg, M; Spano, F; Sperlich, D; Spettel, F; Spieker, TM; Spighi, R; Spigo, G; Spiller, LA; Spousta, M; St Denis, RD; Stabile, A; Stamen, R; Stamm, S; Stanecka, E; Stanek, RW; Stanescu, C; Stanitzki, MM; Stapnes, S; Starchenko, EA; Stark, GH; Stark, J; Stark, SH; Staroba, P; Starovoitov, P; Starz, S; Staszewski, R; Steinberg, P; Stelzer, B; Stelzer, HJ; Stelzer-Chilton, O; Stenzel, H; Stewart, GA; Stockton, MC; Stoebe, M; Stoicea, G; Stolte, P; Stonjek, S; Stradling, AR; Straessner, A; Stramaglia, ME; Strandberg, J; Strandberg, S; Strauss, M; Strizenec, P; Strohmer, R; Strom, DM; Stroynowski, R; Strubig, A; Stucci, SA; Stugu, B; Styles, NA; Su, D; Su, J; Suchek, S; Sugaya, Y; Suk, M; Sulin, VV; Sultan, DMS; Sultansoy, S; Sumida, T; Sun, S; Sun, X; Suruliz, K; Suster, CJE; Sutton, MR; Suzuki, S; Svatos, M; Swiatlowski, M; Swift, SP; Sykora, I; Sykora, T; Ta, D; Tackmann, K; Taenzer, J; Taffard, A; Tafirout, R; Taiblum, N; Takai, H; Takashima, R; Takasugi, EH; Takeshita, T; Takubo, Y; Talby, M; Talyshev, AA; Tanaka, J; Tanaka, M; Tanaka, R; Tanaka, S; Tanioka, R; Taimenwald, BB; Araya, ST; Tapprogge, S; Tarem, S; Tartarelli, GF; Tas, P; Tasevsky, M; Tashiro, T; Tassi, E; Delgado, AT; Tayalati, Y; Taylor, AC; Taylor, GN; Taylor, PTE; Taylor, W; Teixeira-Dias, P; Temple, D; Ten Kate, H; Teng, PK; Teoh, JJ; Tepel, F; Terada, S; Terashi, K; Tenon, J; Terzo, S; Testa, M; Teuscher, RJ; Theveneaux-Pelzer, T; Thomas, JP; Thomas-Wilsker, J; Thompson, PD; Thompson, AS; Thomsen, LA; Thomson, E; Tibbetts, MJ; Tones, RET; Tikhomirov, VO; Tikhonov, YA; Timoshenko, S; Tipton, P; Tisserant, S; Todome, K; Todorova-Nova, S; Tojo, J; Tokar, S; Tokushuku, K; Tolley, E; Tomlinson, L; Tomoto, M; Tompkins, L; Toms, K; Tong, B; Tomambe, P; Torrence, E; Torres, H; Pastor, ET; Toth, J; Touchard, F; Tovey, DR; Treado, CJ; Trefzger, T; Tresoldi, F; Tricoli, A; Trigger, IM; Trincaz-Duvoid, S; Tripiana, MF; Trischuk, W; Trocme, B; Trofymov, A; Troncon, C; Trottier-McDonald, M; Trovatelli, M; Truong, L; Trzebinski, M; Trzupek, A; Tsang, KW; Tseng, JC-L; Tsiareshka, PV; Tsipolitis, G; Tsirintanis, N; Tsiskaridze, S; Tsiskaridze, V; Tskhadadze, EG; Tsui, KM; Tsukerman, II; Tsulaia, V; Tsuno, S; Tsybychev, D; Tu, Y; Tudorache, A; Tudorache, V; Tulbure, TT; Tuna, AN; Tupputi, SA; Turchikhin, S; Turgeman, D; Cakir, IT; Tuna, R; Tuts, PM; Ucchielli, G; Ueda, I; Ughetto, M; Ukegawa, F; Unal, G; Undrus, A; Unel, G; Ungaro, FC; Unno, Y; Unverdorben, C; Urban, J; Urquijo, P; Urrejola, R; Usai, G; Usui, J; Vacavant, L; Vacek, V; Vachon, B; Valderanis, C; Santurio, EV; Valentinetti, S; Valero, A; Valery, L; Valkar, S; Vanier, A; Ferrer, JAV; Van den Wollenberg, W; van der Graaf, H; van Gemmeren, P; Van Nieuwkoop, J; van Vulpen, I; van Woerden, MC; Vanadia, M; Vandelli, W; Vaniachine, A; Vankov, P; Vardanyan, G; Vari, R; Varnes, EW; Varni, C; Varo, T; Varouchas, D; Vartapetian, A; Varvell, KE; Vasquez, JG; Vasquez, GA; Vazeille, F; Schroeder, TV; Veatch, J; Veeraraghavan, V; Veloce, LM; Veloso, F; Veneziano, S; Ventura, A; Venturi, M; Venturi, N; Venturini, A; Vercesi, V; Verducci, M; Verkerke, W; Vermeulen, JC; Vetterli, MC; Maira, NV; Viazlo, O; Vichou, I; Vickey, T; Boeriu, OEV; Viehhauser, GHA; Viel, S; Vigani, L; Villa, M; Perez, MV; Vilucchi, E; Vincter, MG; Vinogradov, VB; Vishwakarma, A; Vittori, C; Vivarelli, I; Vlachos, S; Vlasak, M; Vogel, M; Vokac, R; Volpi, G; Volpi, M; von der Schmitt, H; von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Voss, R; Vossebeld, JH; Vranjes, N; Milosavljevic, MV; Vrba, V; Vreeswijk, M; Vuillermet, R; Vukotic, I; Wagner, P; Wagner, W; Wagner-Kuhr, J; Wahlberg, H; Wahrmund, S; Wakabayashi, J; Walder, J; Walker, R; Walkowiak, W; Wallangen, V; Wang, C; Wang, C; Wang, F; Wang, H; Wang, H; Wang, J; Wang, J; Wang, Q; Wang, R; Wang, SM; Wang, T; Wang, W; Wang, W; Wang, Z; Wanotayaroj, C; Warburton, A; Ward, CP; Wardrope, DR; Washbrook, A; Watkins, PM; Watson, AT; Watson, MF; Watts, G; Watts, S; Waugh, BM; Webb, AF; Webb, S; Weber, MS; Weber, SW; Weber, SA; Webster, JS; Weidberg, AR; Weinert, B; Weingarten, J; Weirich, M; Weiser, C; Weits, H; Wells, PS; Wenaus, T; Wengler, T; Wenig, S; Wermes, N; Werner, MD; Werner, P; Wessels, M; Whalen, K; Whallon, NL; Wharton, AM; White, AS; White, A; White, MJ; White, R; Whiteson, D; Wickens, FJ; Wiedenmann, W; Wielers, M; Wiglesworth, C; Wiik-Fuchs, LAM; Wildauer, A; Wilk, F; Wilkens, HG; Williams, HH; Williams, S; Willis, C; Willocq, S; Wilson, JA; Wingerter-Seez, I; Winkels, E; Winklmeier, F; Winston, OJ; Winter, BT; Wittgen, M; Wobisch, M; Wolf, TMH; Wolff, R; Wolter, MW; Wolters, H; Wong, VWS; Worm, SD; Wosiek, BK; Wotschack, J; Wozniak, KW; Wu, M; Wu, SL; Wu, X; Wu, Y; Wyatt, TR; Wynne, BM; Xella, S; Xi, Z; Xia, L; Xu, D; Xu, L; Yabsley, B; Yacoob, S; Yamaguchi, D; Yamaguchi, Y; Yamamoto, A; Yamamoto, S; Yamanaka, T; Yamauchi, K; Yamazaki, Y; Yan, Z; Yang, H; Yang, H; Yang, Y; Yang, Z; Yao, W-M; Yap, YC; Yasu, Y; Yatsenko, E; Wong, KHY; Ye, J; Ye, S; Yeletskikh, I; Yigitbasi, E; Yildirim, E; Yorita, K; Yoshihara, K; Young, C; Young, CJS; Yu, DR; Yu, J; Yu, J; Yuen, SPY; Yusuff, I; Zabinski, B; Zacharis, G; Zaidan, R; Zaitsev, AM; Zakharchuk, N; Zalieckas, J; Zaman, A; Zambito, S; Zanzi, D; Zeitnitz, C; Zemla, A; Zeng, JC; Zeng, Q; Zenin, O; Enig, T; Zerwas, D; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, M; Zhou, M; Zhou, N; Zhu, CG; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, NI; Zimmermann, C; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Zivkovic, L; Zobernig, G; Zoccoli, A; Zou, R; zur Nedden, M; Zwalinski, L; - view fewer (2017) Heavy Ion Results from ATLAS. Nuclear Physics A , 967 pp. 51-58. 10.1016/j.nuclphysa.2017.05.076 . Green open access

http://ift.tt/2AqJRKz

Detection and characterisation of integrons, gene cassettes and cassette-located antibiotic resistance genes in the human oral metagenome

Rahman, MA; (2017) Detection and characterisation of integrons, gene cassettes and cassette-located antibiotic resistance genes in the human oral metagenome. Doctoral thesis , UCL (University College London).

http://ift.tt/2i0AA59

The Cultural Politics of Englishness: John Gordon Hargrave, the Kibbo Kift and Social Credit, 1920-1939

Qugana, Hana Fe; (2017) The Cultural Politics of Englishness: John Gordon Hargrave, the Kibbo Kift and Social Credit, 1920-1939. Doctoral thesis , UCL (University College London).

http://ift.tt/2AqJTlF

An App to Help Young People Self-Manage When Feeling Overwhelmed (ReZone): Protocol of a Cluster Randomized Controlled Trial

Edbrooke-Childs, J; Smith, J; Rees, J; Edridge, C; Calderon, A; Saunders, F; Wolpert, M; Edbrooke-Childs, J; Smith, J; Rees, J; Edridge, C; Calderon, A; Saunders, F; Wolpert, M; Deighton, J; - view fewer (2017) An App to Help Young People Self-Manage When Feeling Overwhelmed (ReZone): Protocol of a Cluster Randomized Controlled Trial. JMIR Research Protocols , 6 (11) , Article e213. 10.2196/resprot.7019 .

http://ift.tt/2i0Ao5V

Return to the Fourth Nile Cataract: Fieldwork on Sherari Island, 2016

Naeser, C; Weschenfelder, J; Janotte, L; Kossatz, K; Karrar, OKE; (2017) Return to the Fourth Nile Cataract: Fieldwork on Sherari Island, 2016. Sudan & Nubia , 21 pp. 211-219. (In press).

http://ift.tt/2AqrOnH

British policy towards Russian refugees in the aftermath of the Bolshevik Revolution

Multanen, Elina Hannele; (2000) British policy towards Russian refugees in the aftermath of the Bolshevik Revolution. Doctoral thesis (Ph.D), UCL (University College London). Green open access

http://ift.tt/2i0A9b1

The Next 19 Years of the American Head and Neck Society.

The Next 19 Years of the American Head and Neck Society.

JAMA Otolaryngol Head Neck Surg. 2017 Nov 09;:

Authors: Myers JN

Abstract
Jeffrey N. Myers, MD, PhD, president of the American Head and Neck Society (AHNS) for 2016 to 2017, offered his perspectives on the AHNS's history, present-day activities, and future plans at this year's annual meeting of the society. The society was created from the 1998 merger of 2 societies, the Society for Head and Neck Surgeons (SHNS), founded in 1954, and the American Society for Head and Neck Surgery (ASHNS), founded in 1959, to become the largest organization in North America for the advancement of research and education in head and neck oncology. At a recent AHNS leadership retreat, a clear mission statement and core values were codified: the mission of the AHNS is to advance education, research, and the quality of care for head and neck oncology patients, and the core values are patient-centric, ethical, collaborative, innovative, value-based, and global. The educational mission of the society includes its annual meeting held at the Combined Otolaryngology Spring Meetings, and an International Conference on Head and Neck Cancer and hands-on instructional courses in head and neck ultrasonography and transoral robotic surgery. There are also web-based educational opportunities, including surgical videos and a journal club, as well as the oversight of the training of Fellows in Oncologic Head and Neck Surgery through the Advanced Training Council (ATC). The ATC conducts site visits to evaluate each training program every 5 years and is currently focused on developing core curricula for our training programs. Research is another mission critical activity of the AHNS. Each year, the research committee reviews applications from established researchers and trainees for several grants totaling more than $80 000 annually. Prior to this year, the money to support these awards has come from general operating funds from the AHNS annual budget. However, the Research and Education Foundation of the AHNS recently completed one of its major goals of raising $3 million. The interest on this corpus will now provide enough money to make these awards every year in perpetuity, thereby freeing up the AHNS's general operating funds to support other mission critical activities. Given these significant advances in education, research, and fundraising, the AHNS is in "great health" and has a tremendous future in the hands of a talented and diverse group of current and emerging leaders.

PMID: 29121199 [PubMed - as supplied by publisher]

http://ift.tt/2yoSG6W

Granulomatosis With Polyangiitis-A Moral Impetus for Change.

Granulomatosis With Polyangiitis-A Moral Impetus for Change.

JAMA Otolaryngol Head Neck Surg. 2017 Nov 09;:

Authors: Lubitz MG

PMID: 29121164 [PubMed - as supplied by publisher]

http://ift.tt/2AAgMxm

Association Between Cognitive Function and Quality of Life in Patients With Head and Neck Cancer.

Association Between Cognitive Function and Quality of Life in Patients With Head and Neck Cancer.

JAMA Otolaryngol Head Neck Surg. 2017 Nov 09;:

Authors: Williams AM, Lindholm J, Cook D, Siddiqui F, Ghanem TA, Chang SS

Abstract
Importance: There is a dearth of research examining the associations between cognitive function and quality of life (QoL) in patients with head and neck cancer (HNC), despite much research examining QoL and some research examining cognitive function in this population.
Objective: To identify the associations between cognitive functioning and QoL in patients prior to treatment for HNC within a multidisciplinary care team.
Design, Setting, and Participants: Case series with planned data collection of cognitive function, QoL, and psychosocial variables at an urban Midwest academic medical center including 83 patients with a diagnosis of HNC between August 2015 and December 2016 who underwent a pretreatment assessment with a clinical health psychologist and a speech and language pathologist.
Main Outcomes and Measures: At pretreatment assessment, the Montreal Cognitive Assessment and Functional Assessment of Cancer Therapy-Head & Neck, version 4, were administered along with a semistructured interview to gather data on psychiatric symptoms, social support, and substance use. Patient demographic, clinical, and psychosocial variables were extracted via medical record review.
Results: Of 83 patients (64 [77%] male; mean age, 59.54 [95% CI, 57.23-61.73] years), cognitive impairment was identified in 55% (n = 46) at pretreatment. Number of depressive symptoms (mean, 2.43 [95% CI, 2.06-2.89] symptoms) was associated with impairments in delayed recall (r = -0.28; 95% CI, -0.47 to -0.07) and all domains of QoL. Cognitive impairment in delayed recall was associated with lower QoL in both overall QoL and the domains of emotional and functional well-being. Current benzodiazepine use, history of heavy alcohol use, and current and past tobacco use were also associated with lower QoL in specific domains.
Conclusions and Relevance: Cognitive impairment is common in patients with HNC and is associated with QoL and psychosocial variables. Together with previous research indicating that cognitive function and QoL can influence treatment adherence and outcomes, the results argue for the incorporation of cognitive screening and QoL assessment as part of pretreatment assessment for patients.

PMID: 29121151 [PubMed - as supplied by publisher]

http://ift.tt/2yoVJvT

A Systematic Process for Weaning Children With Aspiration From Thickened Fluids.

A Systematic Process for Weaning Children With Aspiration From Thickened Fluids.

JAMA Otolaryngol Head Neck Surg. 2017 Nov 09;:

Authors: Wolter NE, Hernandez K, Irace AL, Davidson K, Perez JA, Larson K, Rahbar R

Abstract
Importance: Thickening of fluids is a common strategy for feeding patients with oropharyngeal dysphagia but has known risks and should be stopped once it is safe to do so. Weaning children from thickened fluids safely can be challenging, and novel methods are required.
Objective: To describe the use of a systematic weaning process (SWP) for children who received thickened liquids owing to oropharyngeal dysphagia and identified risk of aspiration.
Design, Setting, and Participants: Retrospective case series (2010 to 2015) at a tertiary care center of 50 children with documented aspiration by clinical swallowing assessment, airway evaluation, and videofluoroscopic swallow study with at least 4 months of follow-up. All patients were initially receiving thickened fluids. A 10% reduction in thickness was made every 2 weeks based on clinical symptoms. Caregivers progressed to the next incremental level if there were no signs or symptoms of aspiration.
Main Outcomes and Measures: Number of patients weaned to a thin-fluid diet.
Results: Of 50 children (32 [64%] male; median [interquartile range] age, 0.7 [1.0] y at presentation and 1.8 [1.3] y at start of wean) using the SWP, 44 (88%) were able to reduce the amount of thickener used. A successful wean from thickened fluids to thin fluids was completed in 39 (78%). The mean (SD) duration of a successful wean was 0.9 (0.6) years. Five patients tolerated a reduction in thickener but not a full wean to thin fluids. For 6 patients, weaning failed and they continued to receive thickened fluids. Of those whose weaning failed, 2 patients developed pneumonia. Of the 39 successfully weaned patients, 14 (36%) experienced a temporary stall but eventually tolerated thin fluids. Only 2 (5%) developed pneumonia while all other successfully weaned patients (n = 37 [95%]) did not experience any substantial respiratory issues. Overall, 46 (92%) of children required 2 or fewer videofluoroscopic swallow study evaluations.
Conclusions and Relevance: Patients with oropharyngeal dysphagia and aspiration should be gradually weaned off of thickened fluids. The SWP uses small incremental steps to gradually reduce the amount of thickener. Using this method, most children tolerated a reduction in thickeners and a thin-fluid diet. The SWP presents a safe and effective way of gradually returning children to a more normal diet.

PMID: 29121147 [PubMed - as supplied by publisher]

http://ift.tt/2AyGke9