Comparison of Supraclavicular and Infraclavicular Brachial Plexus Block: A Systemic Review of Randomized Controlled Trials.

BACKGROUND: Supraclavicular (SC) and infraclavicular (IC) brachial plexus block (BPB) are commonly used for upper extremity surgery. Recent clinical studies have compared the effect of SC- and IC-BPB, but there have been controversies over spread of sensory blockade in each of the 4 peripheral nerve branches of brachial plexus. METHODS: This study included a systemic review, using the Medline and EMBASE database from their inceptions through March 2016. Randomized controlled trials (RCTs) comparing SC- and IC-BPB were included. The prespecified primary outcome was the incidences of incomplete sensory blockade in each of the 4 terminal nerve branches of brachial plexus. Secondary outcome included the incidence of successful blockade, performance time, onset of sensory block, duration of analgesia, and complication rates. RESULTS: Ten RCTs involving 676 patients were included. Pooled analyses showed the incidence of incomplete block at 30 minutes in radial nerve territory was significantly higher in IC-BPB, favoring SC-BPB (risk ratio 0.39; 95% confidence interval [0.17-0.88], P = .02, I2 = 0%). However, subgroup analysis according to the number of injections of IC-BPB showed that double or triple injections IC-BPB yielded no difference in the incomplete radial block. Furthermore, the incidence of incomplete ulnar block at 30 minutes was significantly lower in IC-BPB when using double or triple injection IC-BPB. There was no difference in the secondary outcomes between SC- and IC-BPB groups, with the exception of complication rates. The incidence of paresthesia/pain on local anesthetic injection, phrenic nerve palsy, and Horner syndrome was significantly higher in the SC group, favoring IC-BPB. CONCLUSIONS: This meta-analysis demonstrated that IC-BPB showed a significantly high incidence of incomplete radial nerve sensory block at 30 minutes, which may be avoided by double or triple injection. Furthermore, IC-BPB with multiple injection technique showed significantly lower incidence of incomplete ulnar block than SC-BPB. There were no differences in the incidence of successful blockade, block onset, and duration of analgesia between SC- and IC-BPB. Procedure-related paresthesia/pain and adjacent nerve-related complications were more frequent in SC-BPB. However, because of the small sample size, publication bias remains a concern when interpreting our results. Further studies with sufficient sample size and reporting large number of outcomes are required. (C) 2016 International Anesthesia Research Society

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Comparison_of_Supraclavicular_and_Infraclavicular.97802.pdf

New Applications for Your Mobile Device.

No abstract available

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/New_Applications_for_Your_Mobile_Device_.97803.pdf

Surveying the Literature: Synopsis of Recent Key Publications.

No abstract available

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Surveying_the_Literature___Synopsis_of_Recent_Key.97804.pdf

Perioperative Anesthesia Care and Tumor Progression.

This narrative review discusses the most recent up-to-date findings focused on the currently available "best clinical practice" regarding perioperative anesthesia care bundle factors and their effect on tumor progression. The main objective is to critically appraise the current literature on local anesthetics, regional outcome studies, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) and their ability to decrease recurrence in patients undergoing cancer surgery. A brief discussion of additional topical perioperative factors relevant to the anesthesiologist including volatile and intravenous anesthetics, perioperative stress and anxiety, nutrition, and immune stimulation is included. The results of several recently published systematic reviews looking at the association between cancer recurrences and regional anesthesia have yielded inconclusive data and provide insufficient evidence regarding a definitive benefit of regional anesthesia. Basic science data suggests an anti tumor effect induced by local anesthetics. New refined animal models show that opioids can safely be used for perioperative pain management. Preliminary evidence suggests that NSAIDs should be an essential part of multimodal analgesia. Volatile anesthetics have been shown to increase tumor formation, whereas preclinical and emerging clinical data from propofol indicate tumor protective qualities. The perioperative period in the cancer patient represents a unique environment where surgically mediated stress response leads to immune suppression. Regional anesthesia techniques when indicated in combination with multimodal analgesia that include NSAIDs, opioids, and local anesthetics to prevent the pathophysiologic effects of pain and neuroendocrine stress response should be viewed as an essential part of balanced anesthesia. (C) 2016 International Anesthesia Research Society

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Perioperative_Anesthesia_Care_and_Tumor.97805.pdf

Individualized Perioperative Bleeding Management.

No abstract available

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Individualized_Perioperative_Bleeding_Management_.97801.pdf

Intranasal Medication Administration Using a Squeeze Bottle Atomizer Results in Overdosing if Deployed in Supine Patients.

BACKGROUND: Vasoconstrictors and local anesthetics are commonly administered using a squeeze bottle atomizer to the nasal mucosa to reduce edema, limit bleeding, and provide analgesia. Despite widespread use, there are few clinical guidelines that address technical details related to safe administration. The purpose of this study was to quantify, via simulation, the amount of liquid delivered to the nasal mucosa when patients are in the supine and upright positions and administration parameters that would reliably provide the desired amount of medication per spray. METHODS: A convenience sample of 10 anesthesia residents was studied. Providers were instructed to use a 25-mL dip and tube nasal squeeze bottle to administer the test solution (sterile water) to a mannequin in the upright (90[degrees] elevation) and supine (0[degrees] elevation) position. After mannequin testing, additional testing was completed with the spray bottles at 0[degrees], 15[degrees], 30[degrees], 45[degrees], and 90[degrees] to determine the relationship between the angles of administration and the amount of liquid dispensed. RESULTS: The mean volume delivered per spray was substantially greater when administered in the supine position (0.56 +/- 0.22 mL) compared with the upright position (0.041 +/- 0.02 mL, difference = 0.52 mL, 95% confidence interval [CI], 0.37-0.67 mL, P =45[degrees]; however, we recommend administering the drug with the patient in the sitting position and the bottle at 90[degrees] because only a small change in angle below 45[degrees] will result in a substantial increase in medication delivered. (C) 2016 International Anesthesia Research Society

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Intranasal_Medication_Administration_Using_a.97806.pdf

Effects of Epidural Labor Analgesia With Low Concentrations of Local Anesthetics on Obstetric Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

BACKGROUND: Low concentrations of local anesthetics (LCLAs) are increasingly popular for epidural labor analgesia. The effects of epidural analgesia with low concentrations of anesthetics on the duration of the second stage of labor and the instrumental birth rate, however, remain controversial. A systematic review was conducted to compare the effects of epidural analgesia with LCLAs with those of nonepidural analgesia on obstetric outcomes. METHODS: The databases of PubMed, Embase, and the Cochrane controlled trials register were independently searched by 2 researchers, and randomized controlled trials that compared epidural labor analgesia utilizing LCLAs with nonepidural analgesia were retrieved. The primary outcomes were the duration of the second stage of labor and the instrumental birth rate; secondary outcomes included the cesarean delivery rate, the spontaneous vaginal delivery rate, and the duration of the first stage of labor. RESULTS: Ten studies (1809 women) were included. There was no significant difference between groups in the duration of the second stage of labor (mean difference = 5.71 minutes, 95% confidence interval [CI]: -6.14 to 17.83; P = .36) or the instrumental birth rate (risk ratio [RR] = 1.52, 95% CI: 0.97-2.4; P = .07). There was no significant difference between groups in the cesarean delivery rate (RR = 0.8, 95% CI: 0.6-1.05; P = .11), the spontaneous vaginal delivery rate (RR = 0.98, 95% CI: 0.91-1.06; P = .62), or the duration of the first stage of labor (mean difference = 17.34 minutes, 95% CI -5.89 to 40.56; P = .14). CONCLUSIONS: Compared with nonepidural analgesia, epidural analgesia with LCLAs is not associated with a prolonged duration of the second stage of labor or an increased instrumental birth rate. The results of this meta-analysis are based on small trials of low quality. These conclusions require confirmation by large-sample and high-quality trials in the future. (C) 2016 International Anesthesia Research Society

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Effects_of_Epidural_Labor_Analgesia_With_Low.97807.pdf

A Pilot Assessment of 3 Point-of-Care Strategies for Diagnosis of Perioperative Lung Pathology.

BACKGROUND: Lung ultrasonography is superior to clinical examination and chest X-ray (CXR) in diagnosis of acute respiratory pathology in the emergency and critical care setting and after cardiothoracic surgery in intensive care. Lung ultrasound may be useful before cardiothoracic surgery and after discharge from intensive care, but the proportion of significant respiratory pathology in this setting is unknown and may be too low to justify its routine use. The aim of this study was to determine the proportion of clinically significant respiratory pathology detectable with CXR, clinical examination, and lung ultrasound in patients on the ward before and after cardiothoracic surgery. METHODS: In this prospective observational study, patients undergoing elective cardiothoracic surgery who received a CXR as part of standard care preoperatively or after discharge from the intensive care unit received a standardized clinical assessment and then a lung ultrasound examination within 24 hours of the CXR by 2 clinicians. The incidence of collapse/atelectasis, consolidation, alveolar-interstitial syndrome, pleural effusion, and pneumothorax were compared between clinical examination, CXR, and lung ultrasound (reference method) based on predefined diagnostic criteria in 3 zones of each lung. RESULTS: In 78 participants included, presence of any pathology was detected in 56% of the cohort by lung ultrasound; 24% preoperatively and 94% postoperatively. With lung ultrasound as a reference, the sensitivity of the 5 different pathologies ranged from 7% to 69% (CXR), 7% to 76% (clinical examination), and 14% to 94% (combined); the specificity of the 5 different pathologies ranged from 91% to 98% (CXR), from 90% to 99% (clinical examination), and from 82% to 97% (combined). For clinical examination and lung ultrasound, intraobserver agreements beyond chance ranged from 0.28 to 0.70 and from 0.84 to 0.97, respectively. The agreements beyond chance of pathologic diagnoses between modalities ranged from 0.11 to 0.64 (CXR and lung ultrasound), from 0.08 to 0.7 (CXR and lung ultrasound), and from 0 to 0.58 (clinical examination and CXR). CONCLUSIONS: Clinically important respiratory pathology is detectable by lung ultrasound in a substantial number of noncritically ill, pre or postoperative cardiothoracic surgery participants with high estimate of interobserver agreement beyond that expected by chance, and we showed clinically significant diagnoses may be missed by the contemporary practice of clinical examination and CXR. (C) 2016 International Anesthesia Research Society

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/A_Pilot_Assessment_of_3_Point_of_Care_Strategies.97808.pdf

Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.

BACKGROUND: Inhalation agents are being used in place of intravenous agents to provide sedation in some intensive care units. We performed a systematic review and meta-analysis of prospective randomized controlled trials, which compared the use of volatile agents versus intravenous midazolam or propofol in critical care units. METHODS: A search was conducted using MEDLINE (1946-2015), EMBASE (1947-2015), Web of Science index (1900-2015), and Cochrane Central Register of Controlled Trials. Eligible studies included randomized controlled trials comparing inhaled volatile (desflurane, sevoflurane, and isoflurane) sedation to intravenous midazolam or propofol. Primary outcome assessed the effect of volatile-based sedation on extubation times (time between discontinuing sedation and tracheal extubation). Secondary outcomes included time to obey verbal commands, proportion of time spent in target sedation, nausea and vomiting, mortality, length of intensive care unit, and length of hospital stay. Heterogeneity was assessed using the I2 statistic. Outcomes were assessed using a random or fixed-effects model depending on heterogeneity. RESULTS: Eight trials with 523 patients comparing all volatile agents with intravenous midazolam or propofol showed a reduction in extubation times using volatile agents (difference in means, -52.7 minutes; 95% confidence interval [CI], -75.1 to -30.3; P

http://pdfs.journals.lww.com/anesthesia-analgesia/9000/00000/Safety_and_Efficacy_of_Volatile_Anesthetic_Agents.97809.pdf

Elbow arthroscopy: setup and portals

Elbow arthroscopy is becoming more and more popular. Compared to open elbow procedure, this surgical technique has several advantages: able to see better, improved access, magnification (a microscope of the elbow), minimal "collateral damage," less scarring, decreased risk of infection, and less postoperative pain. But it also includes some risks that are more common compared to an open procedure like compartment syndrome and transient or permanent nerve injuries.

https://biblio.ugent.be/publication/8135275

Targeted therapy for older patients with uncontrolled severe asthma: current and future prospects

Severe asthma in the elderly places a high burden on affected individuals and society. Emerging therapies target specific phenotypes of the asthma disease spectrum, and can be beneficial for older asthmatics, albeit their response might be altered due to age-related characteristics. Paradoxically, these characteristics are often ground for exclusion from clinical trials. The question thus arises how the senior asthmatic population can successfully enter the era of targeted therapy. Therefore, we highlight characteristics of this population relevant to effective treatment, and review the evidence for targeted therapy in elderly patients. For targeted therapy it is important to account for aging, as this affects the distribution of phenotypes (e.g. late-onset asthma, non-eosinophilic asthma) and may alter biomarkers and drug metabolism. Elderly asthmatics suffer from age-related comorbidities and subsequent polypharmacy. A systematic search into targeted asthma therapy yielded no randomized clinical trials dedicated to older asthmatics. Post hoc analyses of the anti-immunoglobulin E agent omalizumab indicate similar efficacy in both younger and older adults. Conference abstracts on anti-interleukin-5 and anti-interleukin-13 therapy suggest even more pronounced effects of targeted treatments in late-onset disease and in asthmatic patients 65 years or older, but full reports are lacking. For non-eosinophilic asthma in the elderly, there is not yet high-level evidence for targeted therapy, but macrolides may offer a viable option. In conclusion, there is a gap in knowledge regarding the effect of older age on the safety and efficacy of targeted asthma therapy. Further investigations in the elderly are needed, with special emphasis on both late-onset asthma and therapeutics for non-eosinophilic asthma.

https://biblio.ugent.be/publication/8133949

De Europese Unie

https://biblio.ugent.be/publication/8131297

Factors involved in vocal fatigue: a pilot study

https://biblio.ugent.be/publication/8135354

Noot onder Arrondissementsrechtbank Antwerpen 13 november 2015

https://biblio.ugent.be/publication/8131284

Physical examination of the elbow

The evaluation of elbow pain in the athlete can be challenging because of the complexity of the joint and its central location in the upper extremity. Although the elbow is not a weight bearing joint, it is subjected to significant loads, especially in overhead and throwing athletes.

https://biblio.ugent.be/publication/8135291

Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary

Abstract

Microcystic stromal tumors (MCST), first described in 2009 by Irving et al., are rare ovarian neoplasms. The entity was introduced into the 2014 WHO classification of tumors of female reproductive organs in the group of sex cord-stromal tumors, which is rather heterogeneous. We studied three cases of ovarian tumor with the characteristic morphological features and immunohistochemical marker profiles of MCST. The three tumors showed micro, and macrocystic patterns with solid areas, and were composed of small round to spindle-shaped cells, without atypia. The tumors diffusely and strongly expressed CD10, FOXL2, and nuclear β-catenin, but without immmunoreactivity for hormone receptors, calretinin, or inhibin. Genome analyses showed no somatic mutation of exon 1 of the FOXL2 gene and of exons 24 and 25 of DICER1 gene, the latter not having been reported previously. The patients are well, without evidence of tumor progression 1 to 10 years after diagnosis.

The absence of FOXL2 and DICER1 gene mutation, along with strong FOXL2 immunoreactivity provides additional evidence to place MCST within pure gonadal stromal rather than sex cord ovarian tumors.

http://link.springer.com/10.1007/s00428-016-2038-2

Μέν in the Roman and Byzantine papyri. Syntax, semantics and pragmatics

In the first part of this article, I discuss the syntax and semantics of the particle μέν in the Roman and Byzantine papyri (I-VI AD). As previous studies have shown, μέν went ouf of use early on in the Post-classical period. However, the particle is not entirely absent in the documentary papyri: this especially concerns 'co-ordinate' μέν, but examples of 'solitary' μέν can also be found. In the second part, I go into the pragmatics of this particle, discussing the social context in which μέν was used. For this purpose, I turn to Systemic Functional theory, which provides an integrated socio-linguistic framework (Hasan 2009).

https://biblio.ugent.be/publication/8131058

Memory unbound: tracing the dynamics of memory studies

Though still a relatively young field, memory studies has undergone significant transformations since it first coalesced as an area of inquiry. Increasingly, scholars understand memory to be a fluid, dynamic, unbound phenomenon—a process rather than a reified object. Embodying just such an elastic approach, this state-of-the-field collection systematically explores the transcultural, transgenerational, transmedial, and transdisciplinary dimensions of memory—four key dynamics that have sometimes been studied in isolation but never in such an integrated manner. Memory Unbound places leading researchers in conversation with emerging voices in the field to recast our understanding of memory's distinctive variability.

https://biblio.ugent.be/publication/8130403

Heritage and gentrification: remaking urban landscapes in the name of culture and historic preservation

This special issue explores the relationship between heritagization, shifting economies, and urban struggles in different cities around the globe. Our aim is to examine the conditions that have brought history, culture, an old/new urban aesthetics, real estate values, and housing struggles in a relational nexus by looking at the ways in which differently-situated actors mobilize the language of cultural heritage to act upon urban spaces. Ideas of what constitutes a beautiful and livable city are changing along with capital accumulation strategies and urban social geographies. The growing heritagization of historic neighborhoods enables local governments and real-estate developers to engender massive spatial and social changes in the urban landscape. City authorities renovate last swaths of urban fabrics in the name of historic preservation and of the 'common good', but this often means that local residents are evicted while private developers allied with these authorities realize huge profits by 'regenerating' depressed areas. Yet, local residents also resort to the language of cultural heritage to combat the destruction of their urban worlds. What are the consequences for those who cannot afford to live in the newly restored quarters? What kinds of heritage rhetoric are being mobilized by involved actors? How do rooted political cultures shape the local instantiation of this globalizing phenomenon? Recent urban struggles in the Middle East and Europe reveal an inextricable link between heritagization, gentrification, and urban politics. We invite contributors to submit papers dealing with such links between heritagization and housing struggles, evictions, cultural capitalism, and changing urban aesthetics. ​

https://biblio.ugent.be/publication/8131222

Introduction: memory on the move

This introductory essay situates the four sections of the book in ongoing discussions on the methods, ethics, and politics of memory studies. Starting from the observation that memory is increasingly being studied as a dynamic process rather than a static product, it identifies the four main dimensions of mnemonic mobility in a globalized and digitalized world: transcultural, transgenerational, transmedial, and transdisciplinary. Underlining that these four dimensions cannot be studied in isolation from each other, it contends that attention to the interrelations between them is indispensable for the study of memory today. The essay shows how all twelve chapters in the book contribute to the project of capturing the dynamics of memory.

https://biblio.ugent.be/publication/8130407

Prof. dr. Marcel Van Der Straeten (12 september 1924-3 december 2015)

https://biblio.ugent.be/publication/8134334

Gustaaf Hulstaert (1900-1990), autor de manuales escolares en el Congo: pionero paradójico y controversial

https://biblio.ugent.be/publication/8131190

Stabilization of microcirculation in patients with early systemic sclerosis with diffuse skin involvement following rituximab treatment: an open-label study

https://biblio.ugent.be/publication/8133712

Language legislation in the Belgian Colonial Charter of 1908: a textual-historical analysis

https://biblio.ugent.be/publication/8131165

'Même absent, il était présent': Hilaire Delobel (1889-1958) come autor de manuales escolares

https://biblio.ugent.be/publication/8131182

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study

COPD is the third leading cause of death in the world and its global burden is predicted to increase further. Even though the prevalence of COPD is well studied, only few studies examined the incidence of COPD in a prospective and standardized manner. In a prospective population-based cohort study (Rotterdam Study) enrolling subjects aged aeyen45, COPD was diagnosed based on a pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). In absence of an interpretable spirometry within the Rotterdam Study, cases were defined as having COPD diagnosed by a physician on the basis of clinical presentation and obstructive lung function measured by the general practitioner or respiratory physician. Incidence rates were calculated by dividing the number of incident cases by the total number of person years of subjects at risk. In this cohort of 14,619 participants, 1993 subjects with COPD were identified of whom 689 as prevalent ones and 1304 cases as incident ones. The overall incidence rate (IR) of COPD was 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4-9.4. The IR was higher in males and in smokers. The proportion of female COPD participants without a history of smoking was 27.2 %, while this proportion was 7.3 % in males. The prevalence of COPD in the Rotterdam Study is 4.7 % and the overall incidence is approximately 9/1000 PY, with a higher incidence in males and in smokers. The proportion of never-smokers among female COPD cases is substantial.

https://biblio.ugent.be/publication/8133739

Introduction

https://biblio.ugent.be/publication/8131056

Лексема 'общественность' в словарях русского языка

В статье идет речь об истории словарных дефиниций и литературных фиксаций лексемы "общественность" с ее появления в 19 веке до наших дней. Делается попытка новой дефиниции названной лексемы с учетом всех ее старых и современных значений.

https://biblio.ugent.be/publication/7162802

Politieke partijen

https://biblio.ugent.be/publication/8131286

Living tissue and organ donation by minors: suggestions to improve the regulatory framework in Europe

https://biblio.ugent.be/publication/8130396

Five-year survival after endosonography vs mediastinoscopy for mediastinal nodal staging of lung cancer

https://biblio.ugent.be/publication/8134219

AZALEA trial highlights antibiotic overuse in acute asthma attacks

https://biblio.ugent.be/publication/8133943

Long-term outcome and health-related quality of life in difficult-to-wean patients with and without ventilator dependency at ICU discharge: a retrospective cohort study

Background: Long-term outcome and quality of life (QOL) in patients requiring prolonged mechanical ventilation after failure to wean in the ICU is scarcely documented. We aimed to evaluate long-term survival and QOL in patients discharged from the ICU with a tracheostomy for difficult weaning, and with or without ventilator dependency at ICU discharge. Methods: We retrospectively investigated post-ICU trajectories and survival in patients requiring tracheostomy for difficult weaning admitted to the medical ICU of a tertiary center between 1999 and 2013, discriminating between patients who were ventilator dependent or were weaned at ICU discharge. In 2014, a QOL assessment was done in survivors with the use of the Short Form Health Survey (SF-36) and the Severe Respiratory Insufficiency questionnaire. Results: A total of 114 patients was included, of whom 59 were ventilator dependent and 55 were weaned at ICU discharge. One-year survival rates were 73 % and 69 %, respectively. Overall QOL scores for physical functioning were low, and not significantly different between patients ventilated and those weaned at ICU discharge; scores for social functioning and mental health were less below norm and similar between both groups. Conclusions: Long-term survival in patients discharged from the ICU with tracheostomy and ventilator dependency after failure to wean was not significantly different from that of patients with tracheostomy and weaned at ICU discharge. Despite the physical QOL scores being low in both groups, mental QOL was acceptable. Given the intrinsic limitations of this retrospective study, prospective and preferentially multicenter studies are required to confirm these preliminary results.

https://biblio.ugent.be/publication/8133929

Serum phosphate is related to all-cause, cardiovascular and COPD mortality in men: the Rotterdam study

https://biblio.ugent.be/publication/8133915

Changes in initial COPD treatment choice over time and factors influencing prescribing decisions in UK primary care: in UK primary care: a real-world, retrospective, observational

Prescribing patterns in chronic obstructive pulmonary disease (COPD) are often inconsistent with published guidelines. This retrospective, observational study utilised data from the Optimum Patient Care Research Database to examine the changes in COPD prescribing patterns over time and to identify predictors of physician treatment choice for patients newly diagnosed with COPD. Initial therapy was defined as the treatment(s) prescribed at or within 1 year before COPD diagnosis. Changes over time were assessed in three cohorts based on the date of diagnosis: (1) 1997-2001; (2) 2002-2006; and (3) 2007-2010. Factors affecting the odds of being prescribed any initial therapy or any initial maintenance therapy were identified by univariable and multivariable logistic regression. The analysis included 20,154 patients, 45% of whom were prescribed an initial regimen containing an inhaled corticosteroid (ICS), whereas 28% received no initial pharmacological treatment. Prescribing of ICS monotherapy decreased over time, as did the proportion of patients receiving no therapy at or within 1 year before diagnosis. Comorbid asthma, a high exacerbation rate, increased symptoms and poor lung function each increased the likelihood of being prescribed any initial therapy or initial maintenance therapy; comorbid asthma and an annual rate of >= 3 exacerbations were the strongest predictors. In conclusion, our analyses revealed major differences between actual prescribing behaviour and guideline recommendations for patients with newly diagnosed COPD, with many patients receiving no treatment and large numbers of patients receiving ICS-containing regimens. Predictors of initial therapy were identified.

https://biblio.ugent.be/publication/8133863

Prostaglandin D₂ receptor antagonism: a novel therapeutic option for eosinophilic asthma?

https://biblio.ugent.be/publication/8113757

Using a bronchial airway gene expression classifier

https://biblio.ugent.be/publication/8133796

213th ENMC international workshop: Outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18-20 September 2015

https://biblio.ugent.be/publication/8133819

Complementary distribution patterns of arthropod detritivores (woodlice and millipedes) along forest edge-to-interior gradients

1. Worldwide, forest fragmentation induces edge effects, thereby strongly altering the forest microclimate and abiotic characteristics in the forest edge compared to the forest interior. The impact of edge-to-interior gradients on abiotic parameters has been extensively studied, but we lack insights on how biodiversity, and soil communities in particular, are structured along these gradients. 2. Woodlice (Isopoda) and millipedes (Diplopoda) are dominant macro-detritivores in temperate forests with acidic sandy soils. 3. We investigated the distribution of these macro-detritivores along forest edge-to-interior gradients in six different forest stands with sandy soils in northern Belgium. 4. Woodlouse abundance decreased exponentially with distance from the forest edge, whereas millipede abundance did not begin to decrease until 7 m inside the forest stands. Overall, these patterns were highly species specific and could be linked to the species' desiccation tolerance. Whereas the observed abundance patterns were independent from forest stand and dominant tree species, tree species had a large effect on community structure. 5. Edge gradients in macro-detritivores may consequently have implications for nutrient cycling, especially in smaller forest fragments with a large edge-to-interior ratio.

https://biblio.ugent.be/publication/8136333

Trump Wins Presidency and Chance to Dump ACA

The real-estate magnate and reality-TV star who told raucous crowds that he would 'Make America Great Again' now will try to fulfil his promise to dismantle President Barack Obama's signature legislation.
Medscape Medical News

http://www.medscape.com/viewarticle/871580?src=rss

Using a novel spiral-filter press technology to biorefine horticultural by-products: the case of tomato, part II: evaluation of the process impact on the physical tomato juice quality

https://biblio.ugent.be/publication/8136269

Using a novel spiral-filter press technology to biorefine horticultural by-products: the case of tomato, part I: process optimization and evaluation of the process impact on the antioxidative capacity

https://biblio.ugent.be/publication/8136259

Extraction and bioconversion of kaempferol metabolites from cauliflower outer leaves through fungal fermentation

https://biblio.ugent.be/publication/7204779

On the supranational spell of PISA in policy

Baird, J-A; Johnson, S; Hopfenbeck, TN; Isaacs, T; Sprague, T; Stobart, G; Yu, G; (2016) On the supranational spell of PISA in policy. EDUCATIONAL RESEARCH , 58 (2) pp. 121-138. 10.1080/00131881.2016.1165410 .

http://discovery.ucl.ac.uk/1525179/

Flawed self-assessment: Investigating self-and other-perception of second language speech

Trofimovich, P; Isaacs, T; Kennedy, S; Saito, K; Crowther, D; (2016) Flawed self-assessment: Investigating self-and other-perception of second language speech. Bilingualism , 19 (1) pp. 122-140. 10.1017/S1366728914000832 .

http://discovery.ucl.ac.uk/1525231/

Inclusion of Ethnic Minorities in Telehealth Trials for Type 2 Diabetes: Protocol for a Systematic Review Examining Prevalence and Language Issues

Edwards, L; Rooshenas, L; Isaacs, T; (2016) Inclusion of Ethnic Minorities in Telehealth Trials for Type 2 Diabetes: Protocol for a Systematic Review Examining Prevalence and Language Issues. JMIR Research Protocols , 5 (1) , Article e43. 10.2196/resprot.5195 . Green open access

http://discovery.ucl.ac.uk/1525260/

The inclusion of ethnic minority patients and the role of language in telehealth trials for type 2 diabetes: A systematic review

Isaacs, T; Hunt, D; Ward, D; Rooshenas, L; Edwards, L; (2016) The inclusion of ethnic minority patients and the role of language in telehealth trials for type 2 diabetes: A systematic review. Journal of Medical Internet Research , 18 (9) 10.2196/jmir.6374 . Green open access

http://discovery.ucl.ac.uk/1525271/

Lexical correlates of comprehensibility versus accentedness in second language speech

Saito, K; Webb, S; Trofimovich, P; Isaacs, T; (2016) Lexical correlates of comprehensibility versus accentedness in second language speech. Bilingualism , 19 (3) pp. 597-609. 10.1017/S1366728915000255 .

http://discovery.ucl.ac.uk/1525283/

The Epidemiology of First-Episode Psychosis in Early Intervention in Psychosis Services: Findings From the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study

Kirkbride, JB; Hameed, Y; Ankireddypalli, G; Ioannidis, K; Crane, CM; Nasir, M; Kabacs, N; Kirkbride, JB; Hameed, Y; Ankireddypalli, G; Ioannidis, K; Crane, CM; Nasir, M; Kabacs, N; Metastasio, A; Jenkins, O; Espandian, A; Spyridi, S; Ralevic, D; Siddabattuni, S; Walden, B; Adeoye, A; Perez, J; Jones, PB; - view fewer (2016) The Epidemiology of First-Episode Psychosis in Early Intervention in Psychosis Services: Findings From the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study. The American Journal of Psychiatry 10.1176/appi.ajp.2016.16010103 . (In press).

http://discovery.ucl.ac.uk/1527407/

City networks: breaking gridlocks or forging (new) lock-ins?

Acuto, M; Rayner, S; (2016) City networks: breaking gridlocks or forging (new) lock-ins? International Affairs , 92 (5) pp. 1147-1166. 10.1111/1468-2346.12700 . Green open access

http://discovery.ucl.ac.uk/1515989/

Assessing demand for faecal sludge management (FSM) services in Freetown

Parikh, PH; Forte, J; Parkinson, J; Boot, N; (2016) Assessing demand for faecal sludge management (FSM) services in Freetown. Waterlines , 35 (4) pp. 336-356. 10.3362/1756-3488.2016.025 .

http://discovery.ucl.ac.uk/1527408/

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

Scholefield, J; Henriques, R; Savulescu, AF; Fontan, E; Boucharlat, A; Laplantine, E; Smahi, A; Scholefield, J; Henriques, R; Savulescu, AF; Fontan, E; Boucharlat, A; Laplantine, E; Smahi, A; Israël, A; Agou, F; Mhlanga, MM; - view fewer (2016) Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti. Nature Communications , 7 , Article 12629. 10.1038/ncomms12629 . Green open access

http://discovery.ucl.ac.uk/1514419/

Two concepts of justice – and of its scope

Meckled-Garcia, S; (2016) Two concepts of justice – and of its scope. Critical Review of International Social and Political Philosophy , 19 (5) pp. 534-554. 10.1080/13698230.2016.1183750 .

http://discovery.ucl.ac.uk/1515909/

Research timeline: Pronunciation assessment

Isaacs, T; Harding, L; (2017) Research timeline: Pronunciation assessment. Language Teaching (In press). Green open access

http://discovery.ucl.ac.uk/1525434/

All that glisters is not an endophenotype: rethinking endophenotypes in anorexia nervosa

Micali, N; Dahlgren, CL; (2016) All that glisters is not an endophenotype: rethinking endophenotypes in anorexia nervosa. European Child & Adolescent Psychiatry , 25 (11) pp. 1149-1150. 10.1007/s00787-016-0910-x .

http://discovery.ucl.ac.uk/1527413/

Olfactory attraction of Drosophila suzukii by symbiotic acetic acid bacteria

Some species of acetic acid bacteria (AAB) play relevant roles in the metabolism and physiology of Drosophila spp. and in some cases convey benefits to their hosts. The pest Drosophila suzukii harbors a set of AAB similar to those of other Drosophila species. Here, we investigate the potential to exploit the ability of AAB to produce volatile substances that attract female D. suzukii. Using a two-way olfactometer bioassay, we investigate the preference of D. suzukii for strains of AAB, and using solid-phase microextraction gas chromatography-mass spectrometry we specifically characterize their volatile profiles to identify attractive and non-attractive components produced by strains from the genera Acetobacter, Gluconobacter, and Komagataeibacter. Flies had a preference for one strain of Komagataeibacter and two strains of Gluconobacter. Analyses of the volatile profiles from the preferred Gluconobacter isolates found that acetic acid is distinctively emitted even after 2 days of bacterial growth, confirming the relevance of this volatile in the profile of this isolate for attracting flies. Analyses of the volatile profile from the preferred Komagataeibacter isolate showed that a different volatile in its profile could be responsible for attracting D. suzukii. Moreover, variation in the concentration of butyric acid derivatives found in some strains may influence the preference of D. suzukii. Our results indicate that Gluconobacter and Komagataeibacter strains isolated from D. suzukii have the potential to provide substances that could be exploited to develop sustainable mass-trapping-based control approaches.

https://biblio.ugent.be/publication/8136129

Follow the N and P road: high-resolution nutrient flow analysis of the Flanders region as precursor for sustainable resource management

https://biblio.ugent.be/publication/8134674

Environmental impact of non-certified versus certified (ASC) intensive Pangasius aquaculture in Vietnam, a comparison based on a statistically supported LCA

https://biblio.ugent.be/publication/8134204