Frontiers in the Expansion of Bioproducts

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QuiO’s Smartinjector Connected Drug Delivery Device Anticipates 2017 Release

With the launch of QuiO's initial Smartinjector product, the Si One, the company aims to provide the first real-time, connected drug delivery device for injectable therapies. Their Internet of Things (IoT) enabled device and its companion software, which allows medical professionals to monitor adherence and support treatment remotely, looks to offer a long overdue improvement to in-home injection administration technology.

The company was co-founded in early 2014 by CEO Alexander Dahmani, at the time pursuing his Ph.D. in Microbiology and Immunology from Columbia University, and lead engineer Jared Schwartzentruber, himself studying at Columbia's School of Engineering. The pair developed the original functional prototype in Schwartzentruber's bedroom, utilizing a 3D printer than ran continuously for 18 months. QuiO, now based in the Brooklyn Navy Yard and operating out of the New Lab entrepreneurial design and technology center, has come a long way in the time since. Their final prototype device is currently being produced via an FDA-certified development and manufacturing firm, the associated software is finalized pending minor user interface changes, and the company announced last month that they had secured $1.05 million  in funding to enable a 2017 release of the Si One device.

The Si One is capable of administering any type of syringe-based medication, and can in fact be cleared to deliver multiple approved injections in the same syringe by virtue of its designation as a General Use Injector. The technology is designed to prevent against the most frequent self-injection mistakes, such as partial dose delivery. Dose administration is monitored automatically and in real-time via the connected QuiO Cloud HIPAA-compliant software platform. Communication and data transmission between the device and the cloud-based software requires no setup, syncing, or additional components, and is conducted over a cellular connection, rather than through Bluetooth pairing. The QuiO Cloud software, meanwhile, provides web-based dashboards for observing individual patient health status and supporting patient populations. Currently, the QuiO Cloud platform consists of a Care Dashboard, for clinicians and pharmacists to directly track patient injection administration, and an Enterprise Dashboard, through which organizations can monitor drug performance, adherence, and outcomes.

Contacted for an exclusive statement regarding the device and its design process, Dahmani told Medgadget:

"We gave ourselves two very important design constraints with our lead Smartinjector device, the Si One. First off, don't change the drug or syringe, because that slows adoption by pharma and prevents payers and providers from being able to deploy it. Secondly, don't burden the patient, because that reduces clinical efficacy and leads to unreliable data collection. All of the competing devices that we've seen so far break one or both of these rules, which is one of the main reasons we haven't seen much traction in the market to-date. We believe the Si One will be the first solution to be deployed at scale because we made it easy for organizations to adopt and even easier for patients to use."

Currently, QuiO is planning a pilot study to identify the extent to which their Smartinjector platform incentivizes and improves adherence for injectable therapies, as well as to quantify improvements in medical outcomes and patient satisfaction. The Si One is anticipated to receive 510(K) clearance as a Class II General Use Injector in 2017.

More information: QuiO…

This post QuiO's Smartinjector Connected Drug Delivery Device Anticipates 2017 Release appeared first on Medgadget.

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Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up. The AST/ALT ratio increased with increasing BNP levels. And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL). There were 250 all-cause deaths including 79 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without. Conclusions. The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population. Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.

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Diagnostic Utility of ANG in Coronary Heart Disease Complicating Chronic Heart Failure: A Cross-Sectional Study

Angiogenin (ANG) has been shown to be elevated in several cardiovascular diseases. To detect its levels and diagnostic capacity in coronary heart disease (CHD) patients complicating chronic heart failure (CHF), we performed this cross-sectional study and enrolled 616 CHD patients and 53 healthy controls. According to complicating CHF or not, the patients were divided into CHF group () and CHD disease controls (), in which the CHF group was subdivided as heart failure with reduced ejection fraction (HFrEF) group or heart failure with preserved ejection fraction (HFpEF) group on the basis of left ventricular ejection fraction (LVEF), or as different NYHA class group. Their plasma ANG levels were detected using enzyme-linked immunosorbent assay (ELISA). Plasma ANG was 342.8 (IQR []), 304.5 (IQR []), and 279.7 (IQR []) ng/mL in the CHF group, CHD disease controls, and healthy controls, respectively, significantly higher in the CHF group compared with the others. Furthermore, among CHF group, ANG is dramatically higher in the HFrEF patients compared with the HFpEF patients. As for the diagnostic capacity of ANG, the area under the receiver operating characteristic curve was 0.71 (95% CI 0.63–0.78). We concluded that plasma ANG is elevated in CHD complicating CHF patients and may be a moderate discriminator of CHF from CHD or the healthy.

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Structural characterization of natural diamond shocked to 60GPa; implications for Earth and planetary systems

Jones, AP; McMillan, PF; Salzmann, CG; Alvaro, M; Nestola, F; Prencipe, M; Dobson, D; Jones, AP; McMillan, PF; Salzmann, CG; Alvaro, M; Nestola, F; Prencipe, M; Dobson, D; Hazael, R; Moore, M; - view fewer (2016) Structural characterization of natural diamond shocked to 60GPa; implications for Earth and planetary systems. Lithos 10.1016/j.lithos.2016.09.023 . (In press).

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Presentation for care and antenatal management of HIV in the UK, 2009-2014

French, CE; Thorne, C; Byrne, L; Cortina-Borja, M; Tookey, PA; (2016) Presentation for care and antenatal management of HIV in the UK, 2009-2014. HIV Medicine 10.1111/hiv.12410 . (In press). Green open access

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Ridgelet transform on the sphere

McEwen, J; (2015) Ridgelet transform on the sphere. IEEE Transactions on Signal Processing

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Second-Generation Curvelets on the Sphere

Chan, J; Leistedt, B; Kitching, T; McEwen, J; (2016) Second-Generation Curvelets on the Sphere. IEEE Transactions on Signal Processing p. 1. 10.1109/TSP.2016.2600506 .

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From Multilateral to Unilateral Lines of Attack: The Sustainability of Offshore Tax Havens and Financial Centres in the International Legal Order

Chiu, H; (2016) From Multilateral to Unilateral Lines of Attack: The Sustainability of Offshore Tax Havens and Financial Centres in the International Legal Order. Connecticut Journal of International Law (In press).

http://ift.tt/2fnc6Eo

How Do Contextual Factors Influence Implementation and Receipt of Positive Youth Development Programs Addressing Substance Use and Violence? A Qualitative Meta-Synthesis of Process Evaluations

Dickson, K; Melendez-Torres, GJ; Fletcher, A; Hinds, K; Thomas, J; Stansfield, C; Murphy, S; Dickson, K; Melendez-Torres, GJ; Fletcher, A; Hinds, K; Thomas, J; Stansfield, C; Murphy, S; Campbell, R; Bonell, C; - view fewer (2016) How Do Contextual Factors Influence Implementation and Receipt of Positive Youth Development Programs Addressing Substance Use and Violence? A Qualitative Meta-Synthesis of Process Evaluations. American Journal of Health Promotion 10.1177/0890117116670302 . (In press).

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Transcending Regulatory Fragmentation and the Construction of an Economy-Society Discourse: Implications for Regulatory Policy Derived from a Functional Approach to Understanding Shadow Banking

Chiu, H; (2016) Transcending Regulatory Fragmentation and the Construction of an Economy-Society Discourse: Implications for Regulatory Policy Derived from a Functional Approach to Understanding Shadow Banking. Journal of Corporation Law Green open access

http://ift.tt/2fngrr9

Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap

Planck Collaboration, T; Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap. Astronomy & Astrophysics 10.1051/0004-6361/201628636 . (In press).

http://ift.tt/2f5sxS4

Psychological distress in mid-life: evidence from the 1958 and 1970 British birth cohorts

Ploubidis, GB; Sullivan, A; Brown, M; Goodman, A; (2016) Psychological distress in mid-life: evidence from the 1958 and 1970 British birth cohorts. Psychological Medicine 10.1017/S0033291716002464 . (In press).

http://ift.tt/2fnfleZ

Optimising the validity and completion of adherence diaries: a multiple case study and randomised crossover trial

Frost, RH; McClurg, D; Brady, M; Williams, B; (2016) Optimising the validity and completion of adherence diaries: a multiple case study and randomised crossover trial. Trials , 17 , Article 489. 10.1186/s13063-016-1615-7 . Green open access

http://ift.tt/2f5uT3r

Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth

Collaboration, P; Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth. Astronomy & Astrophysics 10.1051/0004-6361/201628890 . (In press).

http://ift.tt/2fnfoHD

Planck intermediate results. XLVII.Constraints on reionization history

McEwen, J; (2016) Planck intermediate results. XLVII.Constraints on reionization history. Astronomy and Astrophysics 10.1051/0004-6361/201628897 .

http://ift.tt/2f5r2mJ

Planck intermediate results. XLIX. Parity-violation constraints from polarization data

Gruppuso, A; Planck intermediate results. XLIX. Parity-violation constraints from polarization data. Astronomy & Astrophysics 10.1051/0004-6361/201629018 . (In press).

http://ift.tt/2fngyTJ

Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies

Remazeilles, M; Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies. Astronomy & Astrophysics 10.1051/0004-6361/201629022 . (In press).

http://ift.tt/2f5uca0

Planck intermediate results. L. Evidence for spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis

McEwen, J; (2016) Planck intermediate results. L. Evidence for spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis. Astronomy and Astrophysics

http://ift.tt/2fni2x1

Planck intermediate results. LI. Features in the cosmic microwave background temperature power spectrum and shifts in cosmological parameters

McEwen, J; (2016) Planck intermediate results. LI. Features in the cosmic microwave background temperature power spectrum and shifts in cosmological parameters. Astronomy and Astrophysics

http://ift.tt/2f5s5Dk

A coalgebraic view on decorated traces

Bonchi, F; Bonsangue, M; Caltais, G; Rutten, J; Silva, A; (2016) A coalgebraic view on decorated traces. Mathematical Structures in Computer Science , 26 (7) pp. 1234-1268. 10.1017/S0960129514000449 .

http://ift.tt/2fn9aI0

Drug Utilisation Patterns in Children Admitted to a Paediatric General Medical Ward in Five Countries.

Rashed, AN; Wong, IC; Wilton, L; Tomlin, S; Neubert, A; Drug Utilisation Patterns in Children Admitted to a Paediatric General Medical Ward in Five Countries. Drugs Real World Outcomes , 2 (4) pp. 397-410. 10.1007/s40801-015-0049-y .

http://ift.tt/2f5skhF

Reflections on Ulrich Beck's legacy in the field of youth transitions and employment

Evans, K; (2016) Reflections on Ulrich Beck's legacy in the field of youth transitions and employment. Work, Employment and Society , 30 (5) pp. 891-892. 10.1177/0950017016645733 . Green open access

http://ift.tt/2fnch2H

Understanding the impact of interventions to prevent antimicrobial resistant infections in the long-term care facility; a review and practical guide to mathematical modelling

Rosello Gilchrist, A; Horner, C; Hopkins, S; Hayward, AC; Deeny, SR; (2016) Understanding the impact of interventions to prevent antimicrobial resistant infections in the long-term care facility; a review and practical guide to mathematical modelling. Infection Control & Hospital Epidemiology (In press).

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Structural characterization of natural diamond shocked to 60GPa; implications for Earth and planetary systems

Jones, AP; McMillan, PF; Salzmann, CG; Alvaro, M; Nestola, F; Prencipe, M; Dobson, D; Jones, AP; McMillan, PF; Salzmann, CG; Alvaro, M; Nestola, F; Prencipe, M; Dobson, D; Hazael, R; Moore, M; - view fewer (2016) Structural characterization of natural diamond shocked to 60GPa; implications for Earth and planetary systems. Lithos 10.1016/j.lithos.2016.09.023 . (In press).

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Stage-specific Embryonic Antigen-4 (SSEA-4) as a novel marker of ductal cells of human eccrine sweat glands

Summary

Background

Different populations of unipotent or multipotent stem cells were identified in human epidermis and its appendages. It is well documented that these cells maintain tissue homeostasis and actively participate in epidermal regeneration after injury. However, there is no evidence of the presence of pluripotent stem cells in human epidermis.

Objective

In this study, we investigated whether cells positive for embryonic stem cell marker SSEA-4 are present in adult human epidermis and if so, whether they are pluripotent and may correspond to the population of primitive stem cells.

Methods

The expression of SSEA-4 antigen and pluripotency transcription factors were analysed using flow cytometry. By means of immunohistochemical staining, we studied the exact localization of these cells in human skin sections.

Results

We show that a population of SSEA-4⁺ cells is present in human epidermis. In contrast to a commonly accepted belief, the expression of SSEA-4 antigen is not connected with the pluripotent character of the isolated cells. We found that these SSEA-4⁺ cells are localized in the ducts of eccrine sweat glands.

Conclusion

Our results indicate that the SSEA-4 antigen is a novel marker identifying the ductal cells of human sweat glands. The surface character of the antigen provides for simple method of isolation of this cell population and suggests the application of SSEA-4 for future cell therapy research.

This article is protected by copyright. All rights reserved.

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Geometric morphometrics of different malocclusions in lateral skull radiographs

Abstract

Background

To evaluate the role of craniofacial shape in malocclusion by application of geometric morphometrics to a set of two-dimensional landmarks and semilandmarks obtained from lateral skull radiographs.

Methods

Cephalometric radiograph tracings of 88 untreated Caucasians (age range 7–39 years) were assigned to four groups according to their occlusion: neutrocclusion, distocclusion, mesiocclusion, and anterior open bite. The geometric morphometric shape analysis incorporated 66 landmarks and semilandmarks, which underwent generalized Procrustes analysis, between-groups principal component analysis, thin-plate spline deformation grid visualization, permutation tests, and receiver operating characteristic curves.

Results

The position and shape of the mandible contributed to differences between the distocclusion and mesiocclusion groups, whereas the maxillary shape showed less variation. The growth-related shape alteration during adolescence was most pronounced in the mesiocclusion group and least pronounced in the neutrocclusion group. The open bite group was associated with an altered orientation of the mandibular body and the maxilla,  showed the most hyperdivergent maxillomandibular pattern but was not an own skeletal entity. Despite clear differences in mean shape across the four groups, the individual distribution of craniofacial shape overlapped between the groups without discrete clusters.

Conclusions

Craniofacial shape was clearly associated with dental malocclusion and showed considerable variation. Geometric morphometrics was a powerful research tool but for diagnosing individual malocclusion standard cephalometric measurements including overjet and overbite were equally or more efficient than geometric morphometric descriptors.

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DOMINO, doxycycline 40mg vs minocycline 100mg in the treatment of rosacea: a randomised, single blinded, non-inferiority trial, comparing efficacy and safety

Summary

Background

There is lack of evidence for minocycline in the treatment of rosacea.

Objectives

To compare the efficacy and safety of doxycycline 40mg versus minocycline 100mg in papulopustular rosacea.

Methods

In this randomised single centre, 1:1 allocation, assessor blinded, non-inferiority trial, patients with a mild to severe papulopustular rosacea, were randomly allocated to either oral doxycycline 40mg or minocycline 100mg for a 16-week period with 12 weeks of follow up.

Our primary outcomes were the change in lesion count and change in patient's Health Related Quality of Life (HRQoL): RosaQoL scores.

Our secondary outcomes were: Patient's Global Assessment (PaGA) success ("excellent" or "good" improvement), Investigator Global Assessment (IGA) success ("clear" or "near clear"), Clinicians Erythema Assessment (CEA) success (at least one point decrease), the relapse rate at follow up and safety profile of the treatment drugs.

Intention to treat (ITT) and per protocol analyses (PPA) were performed.

Results

Of the 80 patients randomised, (40 for minocycline and 40 for doxycycline) 71 patients were treated for 16 weeks. 68 patients completed the study.

At week 16, the median change in lesion count was comparable in both groups: doxycycline versus minocycline respectively 13 versus 14 lesions less. (Non-inferiority difference 3, 90% Confidence interval (CI) -2 to 8). The RosaQoL scores were decreased for both doxycycline and minocycline, respectively 0.62 and 0.86. (Non-inferiority difference 0.15, 90% CI -0.09 to 0.42).

Secondary outcomes were comparable except for IGA success, which was assessed significantly more often in the minocycline group than in the doxycycline group (respectively 60% and 17.5%; p<0.001).

At week 28, outcomes were comparable, except for RosaQoL scores and PaGA, which were significantly different in favour of minocycline (P=0.005 and P=0.043 respectively), and less relapses were recorded in the minocycline group than in the doxycycline group (respectively 6.7% and 48%; p<0.001). In this study no serious adverse reactions (SAEs) were reported.

Conclusions

Minocycline 100mg is non-inferior to doxycycline 40mg in efficacy over a 16- week treatment period. Furthermore, at follow up, RosaQoL scores and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100mg gives longer remission than doxycycline 40mg. In this study there was no significant difference in safety between these treatments, however, based on previous literature minocycline has a lower risk/benefit ratio than doxycycline. Minocycline 100mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40mg.

This article is protected by copyright. All rights reserved.

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Presentation for care and antenatal management of HIV in the UK, 2009-2014

French, CE; Thorne, C; Byrne, L; Cortina-Borja, M; Tookey, PA; (2016) Presentation for care and antenatal management of HIV in the UK, 2009-2014. HIV Medicine 10.1111/hiv.12410 . (In press). Green open access

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Ridgelet transform on the sphere

McEwen, J; (2015) Ridgelet transform on the sphere. IEEE Transactions on Signal Processing

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Second-Generation Curvelets on the Sphere

Chan, J; Leistedt, B; Kitching, T; McEwen, J; (2016) Second-Generation Curvelets on the Sphere. IEEE Transactions on Signal Processing p. 1. 10.1109/TSP.2016.2600506 .

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From Multilateral to Unilateral Lines of Attack: The Sustainability of Offshore Tax Havens and Financial Centres in the International Legal Order

Chiu, H; (2016) From Multilateral to Unilateral Lines of Attack: The Sustainability of Offshore Tax Havens and Financial Centres in the International Legal Order. Connecticut Journal of International Law (In press).

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How Do Contextual Factors Influence Implementation and Receipt of Positive Youth Development Programs Addressing Substance Use and Violence? A Qualitative Meta-Synthesis of Process Evaluations

Dickson, K; Melendez-Torres, GJ; Fletcher, A; Hinds, K; Thomas, J; Stansfield, C; Murphy, S; Dickson, K; Melendez-Torres, GJ; Fletcher, A; Hinds, K; Thomas, J; Stansfield, C; Murphy, S; Campbell, R; Bonell, C; - view fewer (2016) How Do Contextual Factors Influence Implementation and Receipt of Positive Youth Development Programs Addressing Substance Use and Violence? A Qualitative Meta-Synthesis of Process Evaluations. American Journal of Health Promotion 10.1177/0890117116670302 . (In press).

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Transcending Regulatory Fragmentation and the Construction of an Economy-Society Discourse: Implications for Regulatory Policy Derived from a Functional Approach to Understanding Shadow Banking

Chiu, H; (2016) Transcending Regulatory Fragmentation and the Construction of an Economy-Society Discourse: Implications for Regulatory Policy Derived from a Functional Approach to Understanding Shadow Banking. Journal of Corporation Law Green open access

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The expression of serine protease inhibitors in epidermal keratinocytes is increased by calcium, but not 1,25(OH)2 vitamin D3 or retinoic acid

Summary

Background

In the human skin, the serine proteases kallikrein-related peptidases (KLK) 5 and KLK7 degrade corneodesmosome proteins, which leads to desquamation. The serine protease activity of the skin is tightly regulated by the interplay between such proteases and serine protease inhibitors, which include lympho-epithelial Kazal-type related inhibitor (LEKTI) encoded by SPINK5, secretory leukocyte peptidase inhibitor (SLPI), and elafin. The expression of KLK5 and KLK7 is controlled and up-regulated by stimulants such as calcium, 1,25(OH)₂ vitamin D₃ (1,25(OH)₂VD₃), and retinoic acid (RA).

Objectives

To understand the effect of calcium, 1,25(OH)₂VD₃, and RA on the expression of serine protease inhibitors in epidermal keratinocytes.

Methods

We stimulated normal human epidermal keratinocytes (NHEKs) with high calcium, 1,25(OH)₂VD₃, or RA and then analysed the expression of serine protease inhibitors using quantitative real-time-PCR, ELISA, and immunocytofluorescence. We also analysed trypsin- and chymotrypsin-like serine protease activities in stimulated NHEKs.

Results

High calcium, but not 1,25(OH)₂VD₃ or RA, significantly induced the expression of LEKTI, SLPI, and elafin at both transcript and protein levels in NHEKs. These inductions were time- and dose-dependent. The activities of trypsin- and chymotrypsin-like serine proteases were significantly up- and down-regulated by high calcium, respectively, in NHEKs.

Conclusions

High calcium, but not 1,25(OH)₂VD₃ or RA, increases the expression of serine protease inhibitors in epidermal keratinocytes. Our findings contribute to the understanding of the mechanisms by which serine protease activities are regulated by serine proteases and related inhibitors in epidermal keratinocytes.

This article is protected by copyright. All rights reserved.

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Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap

Planck Collaboration, T; Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap. Astronomy & Astrophysics 10.1051/0004-6361/201628636 . (In press).

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Psychological distress in mid-life: evidence from the 1958 and 1970 British birth cohorts

Ploubidis, GB; Sullivan, A; Brown, M; Goodman, A; (2016) Psychological distress in mid-life: evidence from the 1958 and 1970 British birth cohorts. Psychological Medicine 10.1017/S0033291716002464 . (In press).

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Optimising the validity and completion of adherence diaries: a multiple case study and randomised crossover trial

Frost, RH; McClurg, D; Brady, M; Williams, B; (2016) Optimising the validity and completion of adherence diaries: a multiple case study and randomised crossover trial. Trials , 17 , Article 489. 10.1186/s13063-016-1615-7 . Green open access

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Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth

Collaboration, P; Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth. Astronomy & Astrophysics 10.1051/0004-6361/201628890 . (In press).

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Planck intermediate results. XLVII.Constraints on reionization history

McEwen, J; (2016) Planck intermediate results. XLVII.Constraints on reionization history. Astronomy and Astrophysics 10.1051/0004-6361/201628897 .

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Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies

Remazeilles, M; Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies. Astronomy & Astrophysics 10.1051/0004-6361/201629022 . (In press).

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Planck intermediate results. XLIX. Parity-violation constraints from polarization data

Gruppuso, A; Planck intermediate results. XLIX. Parity-violation constraints from polarization data. Astronomy & Astrophysics 10.1051/0004-6361/201629018 . (In press).

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Planck intermediate results. L. Evidence for spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis

McEwen, J; (2016) Planck intermediate results. L. Evidence for spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis. Astronomy and Astrophysics

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Planck intermediate results. LI. Features in the cosmic microwave background temperature power spectrum and shifts in cosmological parameters

McEwen, J; (2016) Planck intermediate results. LI. Features in the cosmic microwave background temperature power spectrum and shifts in cosmological parameters. Astronomy and Astrophysics

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A coalgebraic view on decorated traces

Bonchi, F; Bonsangue, M; Caltais, G; Rutten, J; Silva, A; (2016) A coalgebraic view on decorated traces. Mathematical Structures in Computer Science , 26 (7) pp. 1234-1268. 10.1017/S0960129514000449 .

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Drug Utilisation Patterns in Children Admitted to a Paediatric General Medical Ward in Five Countries.

Rashed, AN; Wong, IC; Wilton, L; Tomlin, S; Neubert, A; Drug Utilisation Patterns in Children Admitted to a Paediatric General Medical Ward in Five Countries. Drugs Real World Outcomes , 2 (4) pp. 397-410. 10.1007/s40801-015-0049-y .

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Reflections on Ulrich Beck's legacy in the field of youth transitions and employment

Evans, K; (2016) Reflections on Ulrich Beck's legacy in the field of youth transitions and employment. Work, Employment and Society , 30 (5) pp. 891-892. 10.1177/0950017016645733 . Green open access

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Medgadget Review: FlipPad, A Rugged Antimicrobial iPad Case

FlipPad is a product of a Chelmsford, Essex, UK-based company called FutureNova. The case is designed to enclose iPad Air 2 & the 9.7″ iPad Pro, and provide all sorts of fluid and chemical protections for these tablets when clinicians, caregivers, company reps and others use them around patients.

Contact precautions and infection control work both ways: you don't want your device to get contaminated in a messy environment, and you don't want it to become a focus of infection in a total joint replacement operating room. Yet, when you bring your device home, you definitely don't want a one year old MRSA leaking off the iPad screen. It's better to keep the iPad behind a wall of protection, and that's what the company believes it offers with the FlipPad. They say the FlipPad provides water and chemical resistance, drop protection, and, thanks to an antimicrobial Corning Gorilla Glass Screen embedded with ionic silver, the device provides antimicrobial resistance. Because the silver ions are permanently embedded into the screen, the effect lasts throughout the lifetime of the device.

A Medgadget editor has tested the device for three weeks doing regular clinical work in the hospital and in the OR, and overall he was very pleased with the device. The case is easy to open and close. After a couple of inadvertent falls, the iPad has survived. The case feels veryrugged, and once the device is positioned inside, it's either surrounded by empty space or securely in contact with a very thick and sturdy looking plastic reinforced by rubber and foam.

We tested the device for splash protection by dunking the entire rig into a bucket of water for about a second. The iPad inside stayed completely dry.

The FlipPad has a specially designed rear handle that also functions as a stand. It's very convenient when holding the device in the air, and it works well as a stand. The little openings for ports are easy to open and close, and they provide a convenient way to charge the iPad while keeping things looking neat.

The touchscreen is crystal clear and is responsive to finger input even when we tested the device with surgical gloves on. Scrolling was easy, but typing was not perfect. Using the virtual keyboard required extra pressure with and without the gloves, and felt inconvenient when we initially started using the FlipPad. After a week or so, typing became a bit more mundane.

The FlipPad is not your typical iPad case, for sure: it comes in a large box, and it's rather bulky. It's not for going out, but it's for the clinical environment where functionality and safety precede beauty. We think the device could be really beneficial for clinicians on rounds and for biomed company reps who attend clinical procedures in sterile areas. It could also be useful to personnel that deal with device processing and sterilization, pathology labs, and other areas where iPads are used for inventory tracking. Morgues and dissection labs are places where FlipPads can also blossom, if you ask us.

Pros: Easy to use rugged antimicrobial case. Responsive clear glass screen. Water and chemicals resistant. Made with FDA approved materials, and, according to the company, tested with the following standard infection control sprays:

• 3000ppm Bleach for 1hr
• 0.75% Sporocidal Active Chlorine for 1hr
• 6% Hydrogen Peroxide for 1hr
• Amonium Chloride + Biguanide for 1hr
•  70% Ethanol for 1hr

Cons: Could be difficult to type, requires extra pressure. The device is not autoclavable. According to the company, "… most of the FlipPad's materials are suitable for autoclaving, but it is not designed for or tested at this high level. We are looking at designing a version of the FlipPad that meets these standards in the future."

Conclusion: If you need to keep your iPad perfectly clean and useful in a clinical environment, the FlipPad is about the only real choice out there. The various usability features make it practical and ergonomic for daily use, something the FlipPad has proven to us during our three weeks with it in the hospital.

 Product page: FlipPad…

This post Medgadget Review: FlipPad, A Rugged Antimicrobial iPad Case appeared first on Medgadget.

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