Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study

Thyroid, Ahead of Print.


https://ift.tt/2pHhyVp

Study of Pre and Post Operative Videostroboscopic Evaluation of Benign Vocal Cord Lesions

Abstract

To determine pre and postoperative vocal fold vibratory changes using videostroboscopy (VS) and effect of surgery on functional, physical and emotional levels of voice using voice handicap index (VHI). To determine correlation between VHI and VS in patients with benign vocal fold pathology. This is a prospective study done at Pushpagiri Medical College. 40 patients in the age group of 14–75 years who presented with complaints of voice change were included. VS and VHI of patients done preoperatively in 40 patients. Patients were re-evaluated postoperatively at 1 month by VHI and VS. All patients underwent microlaryngoscopic excision of the benign vocal cord lesion with biopsy under GA in the conventional manner. One month postoperatively, these patients were evaluated by VS and VHI and the findings noted. There was statistically significant improvement in the stroboscopy ratings and VHI scores post operatively (p < 0.0001). The mucosal wave was diminished or absent in 100% of the studied TVC cysts and present in approximately 60% of vocal polyps. There was no significant correlation found between preoperative VHI scores and stroboscopy ratings except for mucosal waves. Whereas there was significant correlation noted between the VHI subscales and total scores with stroboscopic scores postoperatively except for symmetry. All but 6 patients in this study benefitted from surgery and 85% had a normal voice post-operatively. Pre and post operative assessment of patients with benign vocal fold lesions by stroboscopy and VHI is a useful way to determine the degree of improvement following surgery.

https://ift.tt/2I5hSUD

Study of Pre and Post Operative Videostroboscopic Evaluation of Benign Vocal Cord Lesions

Abstract

To determine pre and postoperative vocal fold vibratory changes using videostroboscopy (VS) and effect of surgery on functional, physical and emotional levels of voice using voice handicap index (VHI). To determine correlation between VHI and VS in patients with benign vocal fold pathology. This is a prospective study done at Pushpagiri Medical College. 40 patients in the age group of 14–75 years who presented with complaints of voice change were included. VS and VHI of patients done preoperatively in 40 patients. Patients were re-evaluated postoperatively at 1 month by VHI and VS. All patients underwent microlaryngoscopic excision of the benign vocal cord lesion with biopsy under GA in the conventional manner. One month postoperatively, these patients were evaluated by VS and VHI and the findings noted. There was statistically significant improvement in the stroboscopy ratings and VHI scores post operatively (p < 0.0001). The mucosal wave was diminished or absent in 100% of the studied TVC cysts and present in approximately 60% of vocal polyps. There was no significant correlation found between preoperative VHI scores and stroboscopy ratings except for mucosal waves. Whereas there was significant correlation noted between the VHI subscales and total scores with stroboscopic scores postoperatively except for symmetry. All but 6 patients in this study benefitted from surgery and 85% had a normal voice post-operatively. Pre and post operative assessment of patients with benign vocal fold lesions by stroboscopy and VHI is a useful way to determine the degree of improvement following surgery.

https://ift.tt/2I5hSUD

The purinergic P2X7 ion channel receptor—a ‘repair’ receptor in bone

Niklas Rye Jørgensen

https://ift.tt/2GckyTO

Anosmia and nasal obstruction

Publication date: Available online 26 March 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): J.J. Braun, S. Riehm




https://ift.tt/2pKUDIV

Correlation between body mass index and obstructive sleep apnea severity indexes — A retrospective study

To evaluate if Body Mass Index (BMI) is correlated to Apnea-Hypopnea Index (AHI), mean arterial oxygen saturation (SaO2) and Nadir SaO2, which are all indexes defining the severity of the respiratory stress associated with Obstructive Sleep Apnea (OSA).

https://ift.tt/2GfetlA

Trend in otolaryngological surgeries in an era of super-aging: Descriptive statistics using a Japanese inpatient database

To reveal the age distribution and capture the longitudinal trend in otolaryngological surgeries performed in Japan, where society is rapidly aging.

https://ift.tt/2IaJFmF

Dilemmas for the pathologist in the oncologic assessment of pancreatoduodenectomy specimens

Abstract

A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival. However, different guidelines diverge on important issues, such as the diagnostic criteria for evaluating the completeness of resection. The macroscopic assessment of the site of origin in periampullary tumors and cystic lesions is influenced by the grossing method. Bi-sectioning of the head of the pancreas may offer an advantage in this respect, as this method allows for optimal visualization of the periampullary area. However, a head-to-head comparison of the assessment of clinically relevant parameters, using axial slicing versus bi-sectioning, is not available yet and the gold standard to compare both techniques prospectively might be subject of debate. Further studies are required to validate the various dissection protocols used for pancreatoduodenectomy specimens and their specific value in the assessment of pathological parameters relevant for prognosis.

https://ift.tt/2pNoaRd

Subungual Atypical Lentiginous Melanocytic Proliferations in Children and Adolescents: A Clinicopathologic Study

Most subungual melanocytic lesions in children are benign, but some are difficult to classify due to prominent lentiginous growth and high-grade cytologic atypia.

https://ift.tt/2IUwLu5

Malignant melanoma associated with chronic once daily aspirin exposure in males: a large, single-center, urban, U.S. patient population cohort study from the Research on Adverse Drug events And Reports (RADAR) project

https://ift.tt/2GfXy29

A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort

Little is known about the impact of nutrition on youthful appearance., Adherence to a recommended healthy diet associates with less wrinkling in women whereas an unhealthy population driven dietary pattern is associated with more facial wrinkling., Dietary recommendations for skin aging preventing strategies could additionally help improve overall health.

https://ift.tt/2IUsk2B

Wound care for Stevens-Johnson Syndrome and toxic epidermal necrolysis; A Systematic Review

https://ift.tt/2pHWopg

An ex-vivo evaluation of cytotoxicity and melanocyte viability after A-101 hydrogen peroxide topical solution 40% or cryosurgery treatment in Seborrheic Keratosis lesions

https://ift.tt/2IUs1ot

Correlation between body mass index and obstructive sleep apnea severity indexes — A retrospective study

Publication date: Available online 27 March 2018
Source:American Journal of Otolaryngology
Author(s): Domenico Ciavarella, Michele Tepedino, Claudio Chimenti, Giuseppe Troiano, Manuela Mazzotta, Maria Pia Foschino Barbaro, Lorenzo Lo Muzio, Michele Cassano
PurposeTo evaluate if Body Mass Index (BMI) is correlated to Apnea-Hypopnea Index (AHI), mean arterial oxygen saturation (SaO2) and Nadir SaO2, which are all indexes defining the severity of the respiratory stress associated with Obstructive Sleep Apnea (OSA).Materials and methodsSeventy-five adult patients (mean age 51.4) referred for polysomnography were retrospectively recruited. BMI was calculated for each patient, as well as AHI, SaO2, and Nadir SaO2 recorded during polysomnography. Spearman's Rho test was used to evaluate if OSA severity was correlated to BMI values. First type error was set as p < 0.025.ResultsNo correlation was observed between BMI and AHI, and between BMI and SaO2. A statistically significant negative correlation (r² = 0.424; p < 0.001) was found between the BMI index and the Nadir SaO2.ConclusionsHigher BMI values were correlated with lower Nadir SaO2 during overnight polysomnography. Since hypoxia stress is a risk factor for cardiovascular diseases and alters the lipid metabolism, dietary consulting should be recommended in association with other treatment modalities for OSA.



https://ift.tt/2DXqLgA

Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2pPbl9g

Anthropometrics and Allometry: Beyond Body Mass Index

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2GcndNj

Comparative Study in Oral, Breast Approach and Open Thyroidectomy

Condition:   Thyroid Neoplasms
Intervention:   Procedure: Thyroid Surgical Methods
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

https://ift.tt/2I7Llgx

Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?

Conditions:   Mild Traumatic Brain Injury;   Balance; Distorted;   Gait, Unsteady;   Quality of Life;   Veterans
Intervention:   Behavioral: Rehabilitation
Sponsors:   Oregon Health and Science University;   United States Department of Defense
Not yet recruiting

https://ift.tt/2GfWJe0

Structure of the catalytic F1 head of the F1-Fo ATP synthase from Trypanosoma brucei [Biological Sciences]

Trypanosoma brucei is the causative agent of sleeping sickness, which is responsible for thousands of deaths per year in developing countries. The single-cell eukaryotic parasite has an elaborate life cycle that involves both an insect vector and a mammalian host. The mitochondrial F1-Fo ATP synthase is crucial for cell survival...

https://ift.tt/2GfwSCI

Listen to the whisper of the rocks, telling their ancient story [Physical Sciences]

Rovere et al. (1) determine the mass of two megaboulders on Eleuthera and calculate hydrologic flow rates based on a tsunami wave model (2). The authors (1) suggest that a rate of ∼10 m/s is required to "lift or roll" these boulders from the cliff-top strata. Their findings ostensibly dispute...

https://ift.tt/2GcSVKy

Reply to Katsu and Baker: Using zebrafish PDX to screen drug sensitivity of endocrine-dependent cancers [Biological Sciences]

Katsu and Baker (1) highlight a potential weakness in using zebrafish patient-derived xenografts (zPDX) (2) for endocrine-dependent tumors. Katsu and Baker (1) report that, unlike human estrogen receptor (ER), progesterone may activate zebrafish mineralocorticoid receptor (MR) instead of inhibiting it (3). Treatment of zPDXs with progesterone would, therefore, possibly activate...

https://ift.tt/2GfwOCY

Reply to Hearty and Tormey: Use the scientific method to test geologic hypotheses, because rocks do not whisper [Physical Sciences]

Hearty and Tormey (1) challenge our conclusions (2), incorrectly arguing that the megaboulders we discuss were shown to originate from the cliff bottom. A number of mischaracterizations are made by Hearty and Tormey (1) in their letter. First, we do not use a "tsunami wave model." Second, we do not...

https://ift.tt/2pJKiMi

Progesterone activation of zebrafish mineralocorticoid receptor may influence growth of some transplanted tumors [Biological Sciences]

Fior et al. (1, 2) provide strong evidence for the benefits of studying the effects of drugs on the growth of human colon cancer explants in zebrafish to identify those drugs that will be effective in treating a specific patient's tumor. Moreover, their work suggests that a similar approach using...

https://ift.tt/2I4Hf8U

Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi [Biochemistry]

The Tudor domain-containing (Tdrd) family proteins play a critical role in transposon silencing in animal gonads by recognizing the symmetrically dimethylated arginine (sDMA) on the (G/A)R motif of the N-terminal of PIWI family proteins via the eTud domains. Papi, also known as "Tdrd2," is involved in Zucchini-mediated PIWI-interacting RNA (piRNA)...

https://ift.tt/2IW8lAq

Correction for Slik et al., Phylogenetic classification of the world’s tropical forests [Correction]

ECOLOGY Correction for "Phylogenetic classification of the world's tropical forests," by J. W. Ferry Slik, Janet Franklin, Víctor Arroyo-Rodríguez, Richard Field, Salomon Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin-Ichiro Aiba, Luciana F. Alves, Anitha K, Andres Avella, Francisco Mora, Gerardo A. Aymard C., Selene Báez, Patricia Balvanera, Meredith L. Bastian, Jean-François...

https://ift.tt/2pKYl4c

Correction for Hoffecker, The complexity of Neanderthal technology [Correction]

COMMENTARY Correction for "The complexity of Neanderthal technology," by John F. Hoffecker, which was first published February 12, 2018; 10.1073/pnas.1800461115 (Proc Natl Acad Sci USA 115:1959–1961). The author notes that, due to a printer's error, the heading of Table 1 appeared incorrectly. "Computational technic of the Paleolithic" should have instead...

https://ift.tt/2IYdDeF

Complex electrophysiological remodeling in postinfarction ischemic heart failure [Physiology]

Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in...

https://ift.tt/2Gc9aaO

Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration [Neuroscience]

Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of "druggable" targets, and the access-limiting blood–retinal barrier (BRB) present major hurdles toward effective therapy development. Here, we address these challenges...

https://ift.tt/2GfwEvm

Cross-resistance to dicamba, 2,4-D, and fluroxypyr in Kochia scoparia is endowed by a mutation in an AUX/IAA gene [Agricultural Sciences]

The understanding and mitigation of the appearance of herbicide-resistant weeds have come to the forefront of study in the past decade, as the number of weed species that are resistant to one or more herbicide modes of action is on the increase. Historically, weed resistance to auxin herbicides has been...

https://ift.tt/2GeRYS0

Linking imaging to omics utilizing image-guided tissue extraction [Medical Sciences]

Phenotypic heterogeneity is commonly observed in diseased tissue, specifically in tumors. Multimodal imaging technologies can reveal tissue heterogeneity noninvasively in vivo, enabling imaging-based profiling of receptors, metabolism, morphology, or function on a macroscopic scale. In contrast, in vitro multiomics, immunohistochemistry, or histology techniques accurately characterize these heterogeneities in the cellular...

https://ift.tt/2I9b2gG

Noncatalytic aspartate at the exonuclease domain of proofreading DNA polymerases regulates both degradative and synthetic activities [Biochemistry]

Most replicative DNA polymerases (DNAPs) are endowed with a 3′-5′ exonuclease activity to proofread the polymerization errors, governed by four universally conserved aspartate residues belonging to the Exo I, Exo II, and Exo III motifs. These residues coordinate the two metal ions responsible for the hydrolysis of the last phosphodiester...

https://ift.tt/2pJK9Zg

Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks [Neuroscience]

Network oscillations across and within brain areas are critical for learning and performance of memory tasks. While a large amount of work has focused on the generation of neural oscillations, their effect on neuronal populations' spiking activity and information encoding is less known. Here, we use computational modeling to demonstrate...

https://ift.tt/2GfIsxW

Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements [Genetics]

RNA-sequencing (RNA-seq) is commonly used to identify genetic modules that respond to perturbations. In single cells, transcriptomes have been used as phenotypes, but this concept has not been applied to whole-organism RNA-seq. Also, quantifying and interpreting epistatic effects using expression profiles remains a challenge. We developed a single coefficient to...

https://ift.tt/2GeRWJS

Transcriptome landscape of a bacterial pathogen under plant immunity [Plant Biology]

Plant pathogens can cause serious diseases that impact global agriculture. The plant innate immunity, when fully activated, can halt pathogen growth in plants. Despite extensive studies into the molecular and genetic bases of plant immunity against pathogens, the influence of plant immunity in global pathogen metabolism to restrict pathogen growth...

https://ift.tt/2GeROdm

CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells [Immunology and Inflammation]

Recent findings demonstrated proinflammatory functions of interleukin (IL)-9–producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expression pattern and, especially, diversity of murine antigen-specific Th9...

https://ift.tt/2pJK8Vc

Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria [Microbiology]

The chemical diversity of physiological DNA modifications has expanded with the identification of phosphorothioate (PT) modification in which the nonbridging oxygen in the sugar-phosphate backbone of DNA is replaced by sulfur. Together with DndFGH as cognate restriction enzymes, DNA PT modification, which is catalyzed by the DndABCDE proteins, functions as...

https://ift.tt/2IV6v2G

Cyclin-dependent kinase activity is required for type I interferon production [Immunology and Inflammation]

Recognition of nucleic acids results in the production of type I IFNs, which activate the JAK/STAT pathway and promote the expression of IFN-stimulated genes. In a search for modulators of this pathway, we discovered an unexpected requirement for cyclin-dependent kinases (CDK) in the production of type I IFN following nucleic...

https://ift.tt/2GeRUle

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy [Neuroscience]

Low-dose ketamine, an open-channel N-methyl d-aspartate receptor (NMDAR) antagonist, mediates rapid antidepressant effects in humans that are mimicked in preclinical rodent models. Disinhibition of pyramidal cells via decreased output of fast-spiking GABAergic interneurons has been proposed as a key mechanism that triggers the antidepressant response. Unfortunately, to date, disinhibition has...

https://ift.tt/2pLV1FY

The Impact of Natural Disasters on Domestic Violence: An Analysis of Reports of Simple Assault in Florida (1999–2007)

Violence and Gender, Ahead of Print.


https://ift.tt/2pOJ2sn

The Importance of the Saphenous Nerve Block for Analgesia Following Major Ankle Surgery: A Randomized, Controlled, Double-Blind Study

Background and Objectives Major ankle surgery causes intense postoperative pain, and whereas the importance of a sciatic nerve block is well established, the clinical significance of a supplemental saphenous nerve block has never been determined in a prospective, randomized, double-blind, placebo-controlled trial. We hypothesized that a saphenous nerve block reduces the proportion of patients experiencing significant clinical pain after major ankle surgery. Methods Eighteen patients were enrolled and received a popliteal sciatic nerve block. Patients were randomized to single-injection saphenous nerve block with 10 mL 0.5% bupivacaine with 1:200,000 epinephrine or 10 mL saline (Fig. 1). Primary outcome was the proportion of patients reporting significant clinical pain, defined as a score greater than 3 on the numerical rating scale. Secondary outcomes were maximal pain and analgesia of the cutaneous territory of the infrapatellar branch of the saphenous nerve. Results Eight of 9 patients in the placebo group reported significant clinical pain versus 1 of 9 patients in the bupivacaine-epinephrine group (P = 0.003). Maximal pain was significantly lower in the active compared with the placebo group (median, 0 [0–0] vs 5 [4–6]; P = 0.001). Breakthrough pain from the saphenous territory began within 30 minutes after surgery in all cases. Sensory testing of the cutaneous territory of the infrapatellar branch of the saphenous nerve showed correlation between pain reported in the anteromedial ankle region and the intensity of cutaneous sensory block in the anteromedial knee region. Conclusions The saphenous nerve is an important contributor to postoperative pain after major ankle surgery, with significant clinical pain appearing within 30 minutes after surgery. Clinical Trials Registration This study has been registered at ClinicalTrials.gov, identifier NCT02697955. Accepted for publication November 20, 2017. Address correspondence to: Thomas Fichtner Bendtsen, MD, PhD, Department of Anesthesiology and Intensive Care Medicine, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus, Denmark (e-mail: tfb@dadlnet.dk). Funding was received from the A. P. Møller and Chastine Mc-Kinney Møller Foundation. The content is solely the responsibility of the authors. The authors declare no conflict of interest. Copyright © 2018 by American Society of Regional Anesthesia and Pain Medicine.

https://ift.tt/2Gsy05B

Too Deep or Not Too Deep?: A Propensity-Matched Comparison of the Analgesic Effects of a Superficial Versus Deep Serratus Fascial Plane Block for Ambulatory Breast Cancer Surgery

Background and Objectives Serratus fascial plane block can reduce pain following breast surgery, but the question of whether to inject the local anesthetic superficial or deep to the serratus muscle has not been answered. This cohort study compares the analgesic benefits of superficial versus deep serratus plane blocks in ambulatory breast cancer surgery patients at Women's College Hospital between February 2014 and December 2016. We tested the joint hypothesis that deep serratus block is noninferior to superficial serratus block for postoperative in-hospital (pre-discharge) opioid consumption and pain severity. Methods One hundred sixty-six patients were propensity matched among 2 groups (83/group): superficial and deep serratus blocks. The cohort was used to evaluate the effect of blocks on postoperative oral morphine equivalent consumption and area under the curve for rest pain scores. We considered deep serratus block to be noninferior to superficial serratus block if it were noninferior for both outcomes, within 15 mg morphine and 4 cm·h units margins. Other outcomes included intraoperative fentanyl requirements, time to first analgesic request, recovery room stay, and incidence of postoperative nausea and vomiting. Results Deep serratus block was associated with postoperative morphine consumption and pain scores area under the curve that were noninferior to those of the superficial serratus block. Intraoperative fentanyl requirements, time to first analgesic request, recovery room stay, and postoperative nausea and vomiting were not different between blocks. Conclusions The postoperative in-hospital analgesia associated with deep serratus block is as effective (within an acceptable margin) as superficial serratus block following ambulatory breast cancer surgery. These new findings are important to inform both current clinical practices and future prospective studies. Accepted for publication November 27, 2017. Address correspondence to: Faraj W. Abdallah, MD, The Ottawa Hospital General Campus, 501 Smyth Rd, Ottawa, Ontario, Canada K1H 8L6 (e-mail: FAbdallah@toh.ca). This work was supported by departmental funding. F.W.A. and R.B. are supported by the Merit Award Program, Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada. R.B. also receives research support from the Evelyn Bateman Cara Operations Endowed Chair in Ambulatory Anesthesia and Women's Health, Women's College Hospital, Toronto. The authors declare no conflict of interest. Copyright © 2018 by American Society of Regional Anesthesia and Pain Medicine.

https://ift.tt/2Ghk5M2

When a transfusion in an emergency service is not really urgent: hyperhaemolysis syndrome in a child with sickle cell disease

A 13-month-old boy with sickle cell disease (SCD) from Equatorial Guinea, who had recently arrived in Spain, presented with fever. He had suffered from malaria and had received a blood transfusion. Following physical examination and complementary tests, intravenous antibiotics and a red blood cell (RBC) transfusion were administered. Soon after a second transfusion 5 days later, the haemoglobin level fell below pretransfusion levels, together with reticulocytopenia, and haematuria—the so-called hyperhaemolysis syndrome—requiring intensive care and treatment with intravenous immunoglobulins and corticosteroids, with resolution of the complication. We want to emphasise the importance of suspecting this rare, though severe complication that can appear after any RBC transfusion especially in patients with SCD, as the clinical syndrome can simulate other more common complications of these patients and a further transfusion is contraindicated. There is no standardised treatment, but intravenous immunoglobulin and corticosteroids are usually effective.

https://ift.tt/2I4KCNl

Brucellosis accompanied by haemophagocytic lymphohistiocytosis and multiple splenic abscesses in a patient with depression

A 39-year-old woman was being treated for depression in our clinic. She subsequently developed a fever and was diagnosed with pancytopenia and moderate splenomegaly. Laboratory and bone marrow results, including markedly increased serum ferritin levels, suggested haemophagocytic lymphohistiocytosis. CT showed multiple splenic abscesses and ovarian vein thrombosis. All laboratory values returned to normal after treatment for culture-positive brucellosis.

https://ift.tt/2IVBFag

Re: “A Follow-Up Strategy for Patients with Excellent Response to Initial Therapy for Differentiated Thyroid Carcinoma” by Jeon et al. (Thyroid 2018;28:187–192)

Thyroid, Ahead of Print.


https://ift.tt/2pIHlfX

Digitalisierung und Big Data – Was nun?

https://ift.tt/2GtAmB9

Natural saliva as an adjuvant in a secondary caries model based on Streptococcus mutans

Publication date: Available online 27 March 2018
Source:Archives of Oral Biology
Author(s): Franziska Hetrodt, Julian Lausch, Hendrik Meyer-Lueckel, Christian Apel, Georg Conrads
ObjectiveTwo factors for secondary caries formation were evaluated using an artificial biofilm model, saliva as additive in culture medium and bonding procedures of composite materials for artificial gap creation.DesignStandardized cavities were prepared in bovine tooth samples (n = 44), treated with two different bonding pretreatments, restored and after artificial ageing incubated with Streptococcus mutans in a Mueller-Hinton-Broth-Sugar medium with or without human saliva for seven days. Secondary caries formation was analyzed using confocal laser scanning microscopy and transversal microradiography.ResultsLesions were significantly pronounced in groups using saliva, but were not influenced by the bonding pretreatments.ConclusionsThe results indicate that the addition of saliva, but not the type of bonding procedure influences the outcome in the present biofilm-based secondary caries model.



https://ift.tt/2GukHS9

Bevacizumab-induced intestinal perforation in a patient with inoperable breast cancer: a case report and review of the literature

Gastrointestinal perforation is known as a serious adverse event, but, for breast cancer, there are very few reports of gastrointestinal perforation. This report highlights gastrointestinal perforation caused ...

https://ift.tt/2uohZZn

TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis

Publication date: Available online 26 March 2018
Source:Allergology International
Author(s): Chuyen Thi Hong Nguyen, Naotomo Kambe, Ikuko Ueda-Hayakawa, Izumi Kishimoto, Nhung Thi My Ly, Kana Mizuno, Hiroyuki Okamoto
BackgroundSarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4⁺ T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown. The objective of this study is to elucidate the role of TARC in sarcoidosis by investigating its expression in peripheral blood and at inflammatory sites. We also examined its relationship with clinical features.MethodsSerum levels of TARC, soluble interleukin 2 receptor, angiotensin-converting enzyme, and lysozyme were measured in 82 sarcoidosis patients. The Th1 and Th2 balance in circulating CD4⁺ T cells was evaluated by flow cytometry. The immunohistochemical staining of TARC and CCR4 was performed in order to identify the source of TARC in affected skin tissues.ResultsTARC serum levels were elevated in 78% of patients and correlated with disease severity. The percentage of CCR4⁺ cells and the CCR4⁺/CXCR3⁺ cell ratios were significantly higher in sarcoidosis patients than in normal subjects (P = 0.002 and P = 0.015, respectively). Moreover, TARC was expressed by monocyte/macrophage lineage cells within granulomas. The abundancy as well as distribution of TARC staining correlated with its serum levels.ConclusionsThe present results suggest that elevations in TARC drive an imbalanced Th2- weighted immune reaction and might facilitate prolonged inflammatory reactions in sarcoidosis.



https://ift.tt/2GsaGVB

Standardising a Moving Target: The Development and Evolution of IoT Security Standards

Brass, I; Tanczer, L; Carr, M; Elsden, M; Blackstock, J; (2018) Standardising a Moving Target: The Development and Evolution of IoT Security Standards. In: (Proceedings) Living in the Internet of Things: A PETRAS, IoTUK & IET Conference, Forum & Exhibition. IET (In press).

https://ift.tt/2Gda6eK

Beliefs and attitudes about addressing alcohol consumption in health care: a population survey in England.

O'Donnell, A; Abidi, L; Brown, J; Karlsson, N; Nilsen, P; Roback, K; Skagerström, J; O'Donnell, A; Abidi, L; Brown, J; Karlsson, N; Nilsen, P; Roback, K; Skagerström, J; Thomas, K; - view fewer (2018) Beliefs and attitudes about addressing alcohol consumption in health care: a population survey in England. BMC Public Health , 18 (1) , Article 391. 10.1186/s12889-018-5275-2 . Green open access

https://ift.tt/2unOmaF

A multicentre, open-label, phase-I/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma

Palmer, DH; Ma, YT; Peck-Radosavljevic, M; Ross, P; Graham, J; Fartoux, L; Deptala, A; ... Meyer, T; + view all Palmer, DH; Ma, YT; Peck-Radosavljevic, M; Ross, P; Graham, J; Fartoux, L; Deptala, A; Studeny, M; Schnell, D; Hocke, J; Loembé, A-B; Meyer, T; - view fewer (2018) A multicentre, open-label, phase-I/randomised phase-II study to evaluate safety, pharmacokinetics, and efficacy of nintedanib vs. sorafenib in European patients with advanced hepatocellular carcinoma. British Journal of Cancer 10.1038/s41416-018-0051-8 . (In press).

https://ift.tt/2GeZPyE

Front-line therapy of advanced ovarian cancer: new approaches

Ledermann, JA; (2017) Front-line therapy of advanced ovarian cancer: new approaches. Annals of Oncology , 28 (Suppl. 8) viii46-viii50. 10.1093/annonc/mdx452 .

https://ift.tt/2uoBWiL

Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model

Jones-Hughes, T; Snowsill, T; Haasova, M; Coelho, H; Crathorne, L; Cooper, C; Mujica-Mota, R; ... Anderson, R; + view all Jones-Hughes, T; Snowsill, T; Haasova, M; Coelho, H; Crathorne, L; Cooper, C; Mujica-Mota, R; Peters, J; Varley-Campbell, J; Huxley, N; Moore, J; Allwood, M; Lowe, J; Hyde, C; Hoyle, M; Bond, M; Anderson, R; - view fewer (2016) Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model. Health Technology Assessment , 20 (62) 10.3310/hta20620 . Green open access

https://ift.tt/2GbHfYr

Potential for harvesting electrical energy from swing and revolving door use

Partridge, JS; Bucknall, RWG; (2018) Potential for harvesting electrical energy from swing and revolving door use. Cogent Engineering (In press).

https://ift.tt/2uoBPUn

Retrieval and registration of long-range overlapping frames for scalable mosaicking of in vivo fetoscopy

Peter, L; Tella-Amo, M; Shakir, DI; Attilakos, G; Wimalasundera, R; Deprest, J; Ourselin, S; Peter, L; Tella-Amo, M; Shakir, DI; Attilakos, G; Wimalasundera, R; Deprest, J; Ourselin, S; Vercauteren, T; - view fewer (2018) Retrieval and registration of long-range overlapping frames for scalable mosaicking of in vivo fetoscopy. International Journal of Computer Assisted Radiology and Surgery 10.1007/s11548-018-1728-4 . (In press). Green open access

https://ift.tt/2GbjRtV

The effects of zinc supplementation on primary human retinal pigment epithelium

Pao, P-J; Emri, E; Abdirahman, SB; Soorma, T; Zeng, H-H; Hauck, SM; Thompson, RB; Pao, P-J; Emri, E; Abdirahman, SB; Soorma, T; Zeng, H-H; Hauck, SM; Thompson, RB; Lengyel, I; - view fewer (2018) The effects of zinc supplementation on primary human retinal pigment epithelium. Journal of Trace Elements in Medicine and Biology 10.1016/j.jtemb.2018.02.028 . (In press).

https://ift.tt/2uoPZ7R

Factors influencing treatment escalation from long-acting muscarinic antagonist monotherapy to triple therapy in patients with COPD: a retrospective THIN-database analysis

Hurst, JR; Dilleen, M; Morris, K; Hills, S; Emir, B; Jones, R; (2018) Factors influencing treatment escalation from long-acting muscarinic antagonist monotherapy to triple therapy in patients with COPD: a retrospective THIN-database analysis. International Journal of Chronic Obstructive Pulmonary Disease , 13 pp. 781-792. 10.2147/COPD.S153655 . Green open access

https://ift.tt/2GbfOxQ

Hypertrophy Regression with N-AcetyLcysTeine in Hypertrophic CardioMyopathy (HALT-HCM): A Randomized Placebo Controlled Double Blind Pilot Study

Marian, AJ; Tan, Y; Li, L; Chang, JT; Syrris, P; Hessabi, M; Rahbar, MH; ... Nagueh, SF; + view all Marian, AJ; Tan, Y; Li, L; Chang, JT; Syrris, P; Hessabi, M; Rahbar, MH; Willerson, JT; Cheong, BY; Liu, C-Y; Kleiman, NS; Bluemke, DA; Nagueh, SF; - view fewer (2018) Hypertrophy Regression with N-AcetyLcysTeine in Hypertrophic CardioMyopathy (HALT-HCM): A Randomized Placebo Controlled Double Blind Pilot Study. Circulation Research 10.1161/CIRCRESAHA.117.312647 . (In press).

https://ift.tt/2uthbSW

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

Zhang, Y; Tech, L; George, LA; Acs, A; Durrett, RE; Hess, H; Walker, LSK; ... Toellner, K-M; + view all Zhang, Y; Tech, L; George, LA; Acs, A; Durrett, RE; Hess, H; Walker, LSK; Tarlinton, DM; Fletcher, AL; Hauser, AE; Toellner, K-M; - view fewer (2018) Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. Journal of Experimental Medicine , 215 (3) 10.1084/jem.20160832 . Green open access

https://ift.tt/2Gc63j9

Communicable disease surveillance and control in the context of conflict and mass displacement in Syria

Ismail, SA; Abbara, A; Collin, SM; Orcutt, M; Coutts, AP; Maziak, W; Sahloul, Z; ... Fouad, FM; + view all Ismail, SA; Abbara, A; Collin, SM; Orcutt, M; Coutts, AP; Maziak, W; Sahloul, Z; Dar, O; Corrah, T; Fouad, FM; - view fewer (2016) Communicable disease surveillance and control in the context of conflict and mass displacement in Syria. International Journal of Infectious Diseases , 47 pp. 15-22. 10.1016/j.ijid.2016.05.011 . Green open access

https://ift.tt/2uoBzon

Genetic basis of arrhythmogenic cardiomyopathy

Karmouch, J; Protonotarios, A; Syrris, P; (2018) Genetic basis of arrhythmogenic cardiomyopathy. Current Opinion in Cardiology 10.1097/HCO.0000000000000509 . (In press).

https://ift.tt/2GebdLu

Hepatitis C virus treatment as prevention in people who inject drugs

Abubakar, II; White, PJ; (2018) Hepatitis C virus treatment as prevention in people who inject drugs. [Rapid communication]. Lancet Infectious Diseases , 18 (4) p. 379. 10.1016/S1473-3099(18)30130-0 .

https://ift.tt/2umqrbN

Non-invasive brain stimulation techniques for chronic pain

O' Connell, NE; Marston, L; Spencer, S; De Souza, LH; Wand, BM; (2018) Non-invasive brain stimulation techniques for chronic pain. Cochrane Database of Systematic Reviews (In press).

https://ift.tt/2Gclsjr

Offer and Use of Smoking-Cessation Support by Depression/Anxiety Status: A Cross-Sectional Survey

Jennifer, M; Brown, J; West, R; Brose, L; Shahab, L; (2018) Offer and Use of Smoking-Cessation Support by Depression/Anxiety Status: A Cross-Sectional Survey. Journal of Smoking Cessation 10.1017/jsc.2018.1 . (In press).

https://ift.tt/2unM9fg

Multi-wavelength campaign on NGC 7469 IV. The broad-band X-ray spectrum

Middei, R; Cappi, M; Petrucci, P-O; Ursini, F; Arav, N; Behar, E; Branduardi Raymont, G; ... Ponti, G; + view all Middei, R; Cappi, M; Petrucci, P-O; Ursini, F; Arav, N; Behar, E; Branduardi Raymont, G; Costantini, E; De Marco, B; Di Gesu, L; Ebrero, J; Kaastra, J; Kaspi, S; Kriss, GA; Mao, J; Mehdipour, M; Paltani, S; Peretz, U; Ponti, G; - view fewer (2018) Multi-wavelength campaign on NGC 7469 IV. The broad-band X-ray spectrum. Astronomy and Astrophysics (In press). Green open access

https://ift.tt/2GagLGN

Bio Mapping: How can we use emotion to articulate cities?

Nold, C; (2018) Bio Mapping: How can we use emotion to articulate cities? Livingmaps Review , 4 Green open access

https://ift.tt/2urUfUi

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

Stickel, F; Buch, S; Nischalke, HD; Weiss, KH; Gotthardt, D; Fischer, J; Rosendahl, J; ... Hampe, J; + view all Stickel, F; Buch, S; Nischalke, HD; Weiss, KH; Gotthardt, D; Fischer, J; Rosendahl, J; Deltenre, P; Marot, A; Elamly, M; Casper, M; Lammert, F; McQuillin, A; Zopf, S; Spengler, U; Marhenke, S; Kirstein, MM; Vogel, A; Eyer, F; von Felden, J; Wege, H; Buch, T; Schafmayer, C; Braun, F; Berg, T; Morgan, MY; Hampe, J; - view fewer (2018) Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis. The American Journal of Gastroenterology 10.1038/s41395-018-0041-8 . (In press).

https://ift.tt/2GeZHPG

Long-term in-situ measurement on an east-facing filled cavity wall in a residential building in the UK

Gori, V; Biddulph, P; Elwell, C; (2018) Long-term in-situ measurement on an east-facing filled cavity wall in a residential building in the UK. [Dataset]. UCL Energy Institute: London, UK.

https://ift.tt/2unm9Ro

Rolle des angeborenen Immunsystems bei Otitis media

Zusammenfassung

Die Otitis media (OM) gehört zu den häufigsten Krankheiten im Kindesalter und ist für mehr Arztbesuche, chirurgische Eingriffe und Medikamentenverordnungen verantwortlich als jede andere Infektionskrankheit. Neuesten Forschungsergebnissen zufolge nimmt das angeborene Immunsystem bei der Bekämpfung der Mittelohrentzündung eine entscheidende Rolle ein. Die Mukosa des Mittelohrs identifiziert das eindringende Pathogen, indem sie „pathogenassoziierte molekulare Muster" (PAMP) über Rezeptoren wie die Toll-like-Rezeptoren (TLR) erkennt. Diese generieren umgehend eine antimikrobielle Immunantwort sowie die Freisetzung von Zytokinen und führen somit zu einer Entzündungsreaktion, wie sie bei der akuten und chronischen OM zu beobachten ist. Durch Interaktion zwischen den verschiedenen TLR kann der Heilungsprozess im Mittelohr sowohl verstärkt als auch gehemmt werden. Um eine Überreaktion auf der einen Seite und eine mangelnde Immunantwort auf der anderen Seite zu verhindern, muss das Signalnetzwerk der Toll-like-Rezeptoren über positive und negative Feedbackschleifen kontrolliert und vernetzt sein. Nur dann kann eine angemessene Immunantwort auf die Infektion im Mittelohr garantiert werden. In der vorliegenden Literaturübersicht liegt das Augenmerk auf der Rolle des angeborenen Immunsystems und der TLR sowie deren Bedeutung bei der Entwicklung von neuen Impfstrategien bzw. Immuntherapien.

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Guía clínica sobre implantes cocleares

Publication date: Available online 26 March 2018
Source:Acta Otorrinolaringológica Española
Author(s): Manuel Manrique, Ángel Ramos, Carlos de Paula Vernetta, Elisa Gil-Carcedo, Luis Lassaleta, Isabel Sanchez-Cuadrado, Juan Manuel Espinosa, Ángel Batuecas, Carlos Cenjor, María José Lavilla, Faustino Núñez, Laura Cavalle, Alicia Huarte
IntroducciónEn la última década son numerosos los hospitales que han iniciado su actividad en pacientes candidatos a un implante coclear (IC), y se han producido numerosos y relevantes avances para el tratamiento de la hipoacusia neurosensorial que han desembocado en una ampliación de las indicaciones de los IC.ObjetivosOfrecer a los especialistas de otorrinolaringología, de otras especialidades médicas, autoridades sanitarias y a la sociedad en general una guía clínica sobre implantes cocleares.MétodosLas comisiones científicas de otología, otoneurología y audiología de la Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello (SEORL-CCC), de manera coordinada y consensuada, han llevado a cabo una revisión del estado actual de los IC basándose en las reglamentaciones existentes y en las publicaciones científicas que se referencian en la bibliografía del documento elaborado.ResultadosLa guía clínica sobre implantes cocleares aporta información sobre: a) definición y descripción sobre IC; b) indicaciones de los IC; y c) requisitos organizativos para un programa de IC.ConclusionesSe ha elaborado por un comité de expertos de la SEORL-CCC una Guía clínica sobre implantes cocleares que aporta coordenadas de actuación para todos aquellos agentes de la sanidad en la toma de decisiones en el ámbito de los IC como forma de tratamiento de la discapacidad auditiva.IntroductionIn the last decade numerous hospitals have started to work with patients who are candidates for a cochlear implant (CI) and there have been numerous and relevant advances in the treatment of sensorineural hearing loss that extended the indications for cochlear implants.ObjectivesTo provide a guideline on cochlear implants to specialists in otorhinolaryngology, other medical specialities, health authorities and society in general.MethodsThe Scientific Committees of Otology, Otoneurology and Audiology from the Spanish Society of Otolaryngology and Head and Neck Surgery (SEORL-CCC), in a coordinated and agreed way, performed a review of the current state of CI based on the existing regulations and in the scientific publications referenced in the bibliography of the document drafted.ResultsThe clinical guideline on cochlear implants provides information on: a) Definition and description of Cochlear Implant; b) Indications for cochlear implants; c) Organizational requirements for a cochlear implant programme.ConclusionsA clinical guideline on cochlear implants has been developed by a Committee of Experts of the SEORL-CCC, to help and guide all the health professionals involved in this field of CI in decision-making to treathearing impairment.



https://ift.tt/2pHPMYD

Floating fifth metacarpal: give conservative management a try!

Abstract

We describe a case of double dislocation of fifth metacarpal (floating metacarpal) in a young adult presenting immediately after injury. He was treated conservatively by closed reduction and immobilization with a wrist brace for 3 weeks. Following above mentioned conservative management, he was pain free and he regained full range of motion and power comparable to contralateral side. Reports on floating metacarpal are rare till date and all of them have been managed surgically. We report a case of such dislocation which was managed successfully with conservative treatment. We advocate conservative management for floating metacarpal if it presents early and if reduction is stable.

https://ift.tt/2Gb9c2y

Malignant transformation of a urachal cyst—a case report and literature review

Abstract

Urachal remnant diseases are very uncommon pathologies which are mostly benign. Rarely they can progress to a very aggressive form of Urachal cancer. The rarity of this condition has precluded large studies to help guide the diagnostic and therapeutic management of these potentially malignant lesions. In this case, a urachal cyst was discovered and conservative management was employed after a biopsy proved the lesion was benign. Unfortunately this patient represented several years later with a locally advanced urachal cancer. To date, this is the first clearly documented case of malignant transformation. The available literature surrounding these urachal cysts and cancers will be reviewed to determine if anything could have been done differently in this case and in the future should a similar case present.

https://ift.tt/2I6Pp0x

Prostatic malakoplakia: a case report with review of the literature

Abstract

Prostatic malakoplakia is a rare benign tumor with few reported cases in the literature. A 61-year-old male with a history of Escherichia coli urinary tract infection (UTI) and gross hematuria presented for evaluation with prostate-specific antigen (PSA) level of 16.0 ng/mL and a 1.5 cm palpable prostatic nodule highly suggestive of prostate cancer. Cystoscopy was unremarkable. Transrectal ultrasound-guided biopsy was performed. Pathologic analysis demonstrated prostatic malakoplakia without evidence of associated malignancy. The patient remains on surveillance with regular physical examination and PSA serum testing. Prostatic malakoplakia is a rare diagnosis with clinical examination findings highly suggestive of prostate cancer and without known associated malignancy risk.

https://ift.tt/2Gamnk8

Johns Hopkins Investigators Unravel Biological Roots of Pulmonary Hypertension

Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death.

https://ift.tt/2ITXs24

A quality improvement project to increase self-administration of medicines in an acute hospital

Garfield, S; Bell, H; Nathan, C; Randall, S; Husson, F; Boucher, C; Taylor, A; ... Franklin, BD; + view all Garfield, S; Bell, H; Nathan, C; Randall, S; Husson, F; Boucher, C; Taylor, A; Lloyd, J; Backhouse, A; Ritchie, L; Franklin, BD; - view fewer (2018) A quality improvement project to increase self-administration of medicines in an acute hospital. International Journal for Quality in Health Care 10.1093/intqhc/mzy035 . (In press). Green open access

https://ift.tt/2DXUxll

Precursors of attachment security

Fearon, RMP; Belsky, J; (2018) Precursors of attachment security. In: Cassidy, J and Shaver, P, (eds.) Handbook of Attachment Theory, Research, and Clinical Applications. (pp. 291-313). Guilford Publications: New York. (In press).

https://ift.tt/2GyVrKn

Reconciling Psychoanalytic Ideas with Attachment Theory

Fonagy, P; Luyten, P; Allison, E; Campbell, C; (2018) Reconciling Psychoanalytic Ideas with Attachment Theory. In: Shaver, P and Cassidy, J, (eds.) Handbook of Attachment. Guilford Press: New York, NY, United States. (In press).

https://ift.tt/2I9ljtv

Testing of timber-to-timber screw-connections in hybrid configurations

Sebastian, W; Schiro, G; Giongo, I; Riccadonna, D; Piazza, M; (2018) Testing of timber-to-timber screw-connections in hybrid configurations. Construction and Building Materials , 171 pp. 170-186. 10.1016/j.conbuildmat.2018.03.078 .

https://ift.tt/2GwbmZT

Attachment, mentalization, and the self

Fonagy, P; Luyten, P; (2018) Attachment, mentalization, and the self. In: Livesley, WJ and Larstone, R, (eds.) Handbook of personality disorders. Guilford Press: New York, NY, USA. (In press).

https://ift.tt/2DY5Fih

Ethnopharmacology – From Mexican Hallucinogens to a Global Transdisciplinary Science

Heinrich, M; Casselman, I; (2018) Ethnopharmacology – From Mexican Hallucinogens to a Global Transdisciplinary Science. In: McKenna, D and Prance, G and De Loenen, B and Davis, W, (eds.) Ethnopharmacologic Search for Psychoactive Drugs: 50 Years of Research (1967-2017). Synergetic Press, in association with Heffter Research Institute: Santa Fe, NM, USA. (In press). Green open access

https://ift.tt/2GtFh4T

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction

Tewari, S; Renney, G; Brewin, J; Gardner, K; Kirkham, F; Inusa, B; Barrett, JE; ... Rees, DC; + view all Tewari, S; Renney, G; Brewin, J; Gardner, K; Kirkham, F; Inusa, B; Barrett, JE; Menzel, S; Thein, SL; Ward, M; Rees, DC; - view fewer (2018) Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction. Haematologica , 103 (4) 10.3324/haematol.2018.187815 . (In press). Green open access

https://ift.tt/2DWe9Gw

Association of Progressive Multifocal Leukoencephalopathy Lesion Volume With JC Virus Polymerase Chain Reaction Results in Cerebrospinal Fluid of Natalizumab-Treated Patients With Multiple Sclerosis

Wijburg, MT; Kleerekooper, I; Lissenberg-Witte, BI; de Vos, M; Warnke, C; Uitdehaag, BMJ; Barkhof, F; ... Wattjes, MP; + view all Wijburg, MT; Kleerekooper, I; Lissenberg-Witte, BI; de Vos, M; Warnke, C; Uitdehaag, BMJ; Barkhof, F; Killestein, J; Wattjes, MP; - view fewer (2018) Association of Progressive Multifocal Leukoencephalopathy Lesion Volume With JC Virus Polymerase Chain Reaction Results in Cerebrospinal Fluid of Natalizumab-Treated Patients With Multiple Sclerosis. JAMA Neurology 10.1001/jamaneurol.2018.0094 . (In press).

https://ift.tt/2unQ3ot

New beginnings: A time-limited, group intervention for high-risk infants and mothers

Baradon, T; Sleed, M; Atkins, R; Campbell, C; Fagin, A; Van Schaick, R; Fonagy, P; (2017) New beginnings: A time-limited, group intervention for high-risk infants and mothers. In: Steele, H and Steele, M, (eds.) Handbook of attachment-based interventions. Guilford Press: New York, NY, USA.

https://ift.tt/2Gxno5i

Learning from Interactions with Prisoners

Gishen, FS; Smolicz, I; Mayhew, J; (2018) Learning from Interactions with Prisoners. The Clinical Teacher (In press).

https://ift.tt/2uk9crC

Naiyena Engol 2 (West Turkana, Kenya): a Case Study on Variability in the Oldowan

Roche, H; de la Torre, I; Arroyo, A; Brugal, J-P; Harmand, S; (2018) Naiyena Engol 2 (West Turkana, Kenya): a Case Study on Variability in the Oldowan. African Archaeological Review , 35 (1) pp. 57-85. 10.1007/s10437-018-9283-5 .

https://ift.tt/2GsKgmz

Attachment and mentalization efforts to promote creative learning in kindergarten through fifth grade elementary school students with broad extension to all grades and some organizations

Twemlow, S; Fonagy, P; Campbell, C; Sacco, FC; (2017) Attachment and mentalization efforts to promote creative learning in kindergarten through fifth grade elementary school students with broad extension to all grades and some organizations. In: Steele, H and Steele, M, (eds.) Handbook of attachment-based interventions. Guilford Press: New York, NY, USA.

https://ift.tt/2uov2tJ

Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity

Zarouchlioti, C; Sanchez-Pintado, B; Hafford Tear, NJ; Klein, P; Liskova, P; Dulla, K; Semo, M; ... Davidson, AE; + view all Zarouchlioti, C; Sanchez-Pintado, B; Hafford Tear, NJ; Klein, P; Liskova, P; Dulla, K; Semo, M; Vugler, AA; Muthusamy, K; Dudakova, L; Levis, HJ; Skalicka, P; Hysi, P; Cheetham, ME; Tuft, SJ; Adamson, P; Hardcastle, AJ; Davidson, AE; - view fewer (2018) Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity. The American Journal of Human Genetics 10.1016/j.ajhg.2018.02.010 . (In press). Green open access

https://ift.tt/2GALQTc

Discrete-choice experiment to analyse preferences for centralizing specialist cancer surgery services

Vallejo-Torres, L; Melnychuk, M; Vindrola-Padros, C; Aitchison, M; Clarke, CS; Fulop, NJ; Hines, J; ... Morris, S; + view all Vallejo-Torres, L; Melnychuk, M; Vindrola-Padros, C; Aitchison, M; Clarke, CS; Fulop, NJ; Hines, J; Levermore, C; Maddineni, SB; Perry, C; Pritchard-Jones, K; Ramsay, AIG; Shackley, DC; Morris, S; - view fewer (2018) Discrete-choice experiment to analyse preferences for centralizing specialist cancer surgery services. British Journal of Surgery 10.1002/bjs.10761 . Green open access

https://ift.tt/2ujyS7q

The neurochemistry of agitation in Alzheimer's disease: a systematic review

Liu, KY; Stringer, AE; Reeves, SJ; Howard, RJ; (2018) The neurochemistry of agitation in Alzheimer's disease: a systematic review. Ageing Research Reviews , 43 pp. 99-107. 10.1016/j.arr.2018.03.003 .

https://ift.tt/2GvcrkB

Prevalence and associated factors of preoperative functional disability in elective surgical patients over 55 years old: a prospective cohort study

Abstract

Purpose

In preoperative settings, patients may have functional disabilities due to the disease for which surgery is being performed or comorbidities, but the associated and predictive factors remain unknown. This study examined the prevalence of preoperative functional disability and clarified the associated factors.

Methods

Individuals aged ≥ 55 years who were scheduled to undergo surgery in a tertiary-care hospital in Japan between April 2016 and September 2016 were eligible for enrolment in the study. Patients with the diseases requiring psychiatric treatment and patients unable to complete the questionnaire without help were excluded. After obtaining informed consent, each patient was asked to complete the 12-item World Health Organization Disability Assessment Schedule-2.0, which is a standardized evaluation tool for assessing comprehensive living function. Data from these questionnaires and the patients' characteristics were evaluated. Multiple logistic regression analysis was conducted to determine independent factors associated with preoperative functional disability.

Results

Of 1201 recruited patients, 912 (75.9%) were included in our analysis. The prevalence of preoperative functional disability was 29.2%. Regression analysis identified six independent associated factors for preoperative functional disability: body mass index ≥ 30 kg m⁻², mixed lung disease, serum albumin values, malnutrition, risk of malnutrition, and preoperative use of corticosteroids.

Conclusions

In total, 29.2% of preoperative patients had functional disability. Obesity, nutritional deficiency, respiratory complications, and low serum albumin values were determined as potentially modifiable factors.

https://ift.tt/2Ggg0b6

Streptococcus pyogenes primary peritonitis

Streptococcus pyogenes, a Gram-positive bacterium, is a rare cause of primary peritonitis. Diagnosed on imaging and with positive growth in blood cultures, a case of primary peritonitis caused by S. pyogenes is discussed here, with a brief literature review, and used to discuss several key principles of antibiotic use, including selection of antibiotic, investigations and non-pharmacological management of infection.

https://ift.tt/2uoinXJ

Intrathecal spinal abscesses due to Candida albicans in an immunocompetent man

Infections of the central nervous system due to Candida albicans are uncommon and are usually only observed in special circumstances, such as following neurosurgery or penetrating head trauma, in immunosuppressed patients, premature infants or in patients with ventriculoperitoneal shunts. The author reports a case of an immunocompetent man who presented with a thoracic intraspinal abscess due to C. albicans. Despite surgical drainage and 6 weeks of high-dose fluconazole therapy, the abscess extended and recurred in the cervical spine, requiring a second operation to arrest the infection.

https://ift.tt/2IY1lD0

Severe immune thrombocytopaenia in a patient taking benznidazole for chronic Chagas disease

Chagas disease is a parasitic disease that mostly affects Latin American countries, but it has currently become a worldwide epidemic due to migration. Both drugs marketed for its treatment (benznidazole and nifurtimox) are associated with a high rate of adverse reactions. Benznidazole is preferred initially because of its more favourable toxicity profile and perceived greater efficacy. Hypersensitivity dermatological reactions, gastrointestinal and neurological disturbances represent the most common drug-related adverse events. General symptoms such as fever, arthralgia, myalgia or bone marrow depression (leucopaenia) are seen less frequently. We describe the case of a 33-year-old woman with chronic Chagas disease who presented with acute gingival bleeding and severe thrombocytopaenia, probably related to benznidazole treatment. Temporal association with drug initiation and recovery after treatment withdrawal were demonstrated. Clinicians should be aware of the possible association between immune thrombocytopaenia and benznidazole, even though the pathogenesis remains unclear at present.

https://ift.tt/2uswrzs

Therapeutic plasma exchange for severe hyperlipidaemia in a patient with poorly controlled diabetes

Description

Hypertriglyceridaemia (HTG) is a common condition in the USA and is often caused or exacerbated by uncontrolled diabetes mellitus (DM), obesity and other metabolic disorders. It is usually asymptomatic until triglycerides exceed 1000 mg/dL. Signs include gastrointestinal pain, nausea, vomiting and dyspnoea. In type I DM, insulin deficiency leads to an inhibition of lipoprotein lipase (LpL).1 Control with insulin restores LpL function and reduces triglyceride levels. While initiating glucose control, therapeutic plasma exchange (TPE) can be used adjunctively, with intravenous insulin, to rapidly decrease triglyceride levels and prevent acute pancreatitis.

A man of 30 with poorly controlled type I DM, secondary to gallstone pancreatitis, presented for treatment of abdominal pain, nausea, vomiting and HTG. His father also has HTG, but no genetic testing for inherited lipid disorders has been pursued. The patient's initial glucose level was 335 mg/dL and his HbA1c was 14.2%. His lipid panel included...

https://ift.tt/2IY1eY6

Leiomyosarcoma: a rare sinonasal malignancy

Leiomyosarcomas (LMS) are rare sinonasal malignant tumours with 20 cases of nasal LMS previously reported in the literature. An 81-year-old man presented with an incidental left nasal lesion associated with left nasal obstruction and occasional left-sided blood-stained rhinorrhoea. Nasendoscopic examination showed green coloured polyps filling the left nasal cavity with biopsies showing LMS. CT imaging did not show any bony erosion. No metastases were found on positron emission tomography imaging. The patient underwent endoscopic resection and all surgical margins were clear of disease. The patient was declined postoperative radiotherapy, and serial follow-up has not shown any recurrence to date. Nasal LMS are rare sinonasal smooth muscle tumours and symptoms and radiological findings are often non-specific. Therefore, diagnosis is made on histopathological and immunohistochemical analysis. Due to their invasive nature, the treatment of choice is complete surgical resection, with adjuvant therapy reserved for patients with locally advanced or metastatic disease.

https://ift.tt/2IY19DM

Episodes of extreme lower leg pain caused by intraosseous varicose veins

We present a case of a 67-year-old man with episodes of extreme pain of the right lower extremity that prevented him from walking and sleeping. The patient had a history of varices in both legs. Physical examination showed a pretibial varix of the right leg inferiorly from a painful spot. X-ray of the right lower leg showed a cortex disruption at this spot. MRIs confirmed the disruption of the cortex of the right tibia and demonstrated an intraosseous vessel. The diagnosis intraosseous varices was made and the vein was surgically resected. Follow-up took place after 3 years and the patient was free from any symptoms related to the intraosseous varicose vein. The pathophysiology causing the pain symptoms is hard to understand, partly due to the limited cases presented with such anomalies. We demonstrate our case in the hope to generate more knowledge about this disorder.

https://ift.tt/2un1LQh

Alveolar rhabdomyosarcoma presenting as a lung mass: an uncommon presentation of a less common tumor

Description

Case: a male in his early 20s presented to the emergency department with back pain and abdominal pain for 1 month. The patient also complained of progressively worsening cough and shortness of breath. CT of the chest showed a very large enhancing destructive right lung mass with massive right pleural effusion, which caused a shift of mediastinal structures to the left as well as the significant mass effect on organs in the upper abdomen (figures 1 and 2). CT-guided biopsy of the mass and thoracocentesis was then performed. Histopathology showed nests of small round cells with hyperchromatic nuclei and surrounded by fibrous trabeculae. The tissue had areas of loss of cellular cohesion forming spaces suggestive of an alveolar pattern (figures 3 and 4). It containedPeriodic Acid-Schiff (PAS)positive glycogen as well. According to the TNM Classification of malignant tumours (TNM), it...

https://ift.tt/2IWzeED

Regression of human cirrhosis: an update, 18 years after the pioneering article by Wanless et al.

Abstract

Cirrhosis has been traditionally viewed as an irreversible, end-stage condition. Eighteen years ago, Wanless, Nakashima, and Sherman published a study that was based on the concept that hepatic architecture is under constant remodeling in the course of chronic liver diseases, even during their most advanced stages; depending on the balance between injury and repair, the histologic changes might be progressing or regressing. These authors described in detail the morphologic features of regressing cirrhosis, identified a set of histologic features of regression that they called the "hepatic repair complex," and provided convincing morphologic evidence that incomplete septal cirrhosis represents regressed cirrhosis. In the years that followed publication of this pioneering article, a number of clinical studies with performance of pre- and post-treatment liver biopsies provided abundant evidence that cirrhosis can regress after successful therapy of chronic hepatitis B, chronic hepatitis C, autoimmune hepatitis, and genetic hemochromatosis. Evidence for other chronic liver diseases may also be provided in the future, pending ongoing studies. Successful therapy allows resorption of fibrous septa, which can be followed by loss of nodularity and architectural improvement; however, many vascular lesions of cirrhotic livers are not thought to regress. Cases of cirrhosis that are considered more likely to improve than others include those of recent onset, with relatively thin fibrous septa and mild vascular changes. Histologic examination of liver biopsy specimens from patients with chronic liver diseases provides the opportunity to appreciate the features of the hepatic repair complex on a routine diagnostic basis; however, interpretation is often difficult, and can be aided by immunohistochemical stains. Clinicopathologic correlation is essential for a meaningful assessment of such cases. For many patients, cirrhosis is not an end-stage condition anymore; therefore, use of the term "cirrhosis" has been challenged, almost 200 years after its invention. However, regression of cirrhosis does not imply regression of molecular changes involved in hepatocarcinogenesis; therefore, surveillance for hepatocellular carcinoma should be continued in these patients.

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Tinea capitis und Onychomykose durch Trichophyton soudanense

Zusammenfassung

Zwei afrikanische Mädchen, die erst vor ca. 4 Wochen nach Deutschland gezogen waren, stellten sich mit juckenden und schuppenden Hautveränderungen an der behaarten Kopfhaut vor. Das gesamte Kapillitium war mit einer weißen, trockenen, schuppenden Kruste überzogen. An den Oberschenkeln sah man trockene, kreisrunde, randbetonte, erythematosquamöse Läsionen. Der linke Daumennagel des jüngeren Mädchens war oberflächlich weißlich verfärbt. Das unter dem Verdacht auf eine Tinea capitis et corporis sowie Onychomykose durchgeführte Blankophor-Präparat aus Kopfschuppen, Hautschuppen vom Oberschenkel und Nagelspänen vom Daumen war positiv. Kulturell ließ sich aus 3 Haut- und Nagelproben Trichophyton (T.) soudanense isolieren. Die Pilzisolate wurden zur Bestätigung der Identifizierung einer Sequenzierung der Internal-Transcribed-Spacer(ITS)-Region der ribosomalen Desoxyribonukleinsäure (rDNA) sowie des TEF1α(„translation elongation factor 1α")-Gens unterzogen. Die Speziesidentifizierung T. soudanense wurde bestätigt. Im phylogenetischen Stammbaum – Dendrogramm – unterschieden sich die T.-soudanense-Stämme genetisch klar von T. rubrum. Dagegen erlaubte die Sequenzierung des TEF1α-Gens keine Unterscheidung zwischen T. soudanense und T. rubrum. Beide Mädchen wurden systemisch antimykotisch mit Fluconazol behandelt. Topisch kamen bei beiden Mädchen Ciclopiroxolamin und Terbinafin (jeweils 1‑mal täglich) als Lösung bzw. Creme zur Anwendung. Nach 8 Wochen oraler Fluconazol-Therapie war die Dermatomykose der Haut, Haare und des Daumennagels bei beiden Kindern komplett geheilt. T. soudanense ist ein aus Afrika stammender anthropophiler Dermatophyt, mit dem in Deutschland und Europa zunehmend gerechnet werden muss. Die kulturelle Identifizierung des Erregers ist relativ einfach. Molekulare Methoden erlauben zudem die genaue Unterscheidung von T. violaceum und T. rubrum.

https://ift.tt/2GwRSo0

Antiphospholipid syndrome presenting as acute mesenteric venous thrombosis involving a variant inferior mesenteric vein and successful treatment with rivaroxaban

Acute mesenteric venous thrombosis (MVT) is the rarest cause of acute mesenteric ischaemia, so thrombosis of a variant inferior mesenteric vein (IMV) is especially uncommon in the setting of antiphospholipid syndrome (APS). Here, we present such a case of seronegative APS initially manifesting as an anomalous IMV thrombosis in a 76-year-old woman. Although guidelines support anticoagulation with vitamin K antagonists in these patients, we anticoagulated with rivaroxaban (a direct oral anticoagulant (DOAC)) due to patient preference, which resulted in complete clinical and endoscopic resolution. IMV thrombosis is a rare form of MVT, only two case reports describe successful anticoagulation with DOACs in the setting of MVT and none report APS as an underlying aetiology. Therefore, this case provides the opportunity to review the pathophysiology of MVT, APS and their medical management including current trends in anticoagulation.

https://ift.tt/2GbaPgK

Investing in Time-to-Build Projects With Uncertain Revenues and Costs: A Real Options Approach

Kauppinen, L; Siddiqui, AS; Salo, A; (2018) Investing in Time-to-Build Projects With Uncertain Revenues and Costs: A Real Options Approach. IEEE Transactions on Engineering Management 10.1109/TEM.2018.2803304 . (In press). Green open access

https://ift.tt/2GyV7LT

Giving Children’s Views “Due Weight” in Medical Law

Alderson, P; (2018) Giving Children's Views "Due Weight" in Medical Law. International Journal of Children's Rights , 26 pp. 16-37. 10.1163/15718182-02601001 .

https://ift.tt/2pJXT6n

Supporting future-proof healthcare design by narrowing the design space of solutions using building information modelling

Krystallis, I; Demian, P; Price, A; (2013) Supporting future-proof healthcare design by narrowing the design space of solutions using building information modelling. In: Smith, SD and Ahiaga-Dagbui, DD, (eds.) Proceedings of the 29th Annual ARCOM Conference 2013. Association of Researchers in Construction Management (ARCOM) Green open access

https://ift.tt/2GsonUi

A notation for describing the steps in indicator expansion

Spring, JM; (2014) A notation for describing the steps in indicator expansion. In: 2013 APWG eCrime Researchers Summit. IEEE Green open access

https://ift.tt/2pKxhSC

Market Power with Combined Heat and Power Production in the Nordic Energy System

Virasjoki, V; Siddiqui, AS; Zakeri, B; Salo, A; (2018) Market Power with Combined Heat and Power Production in the Nordic Energy System. IEEE Transactions on Power Systems 10.1109/TPWRS.2018.2811959 . (In press). Green open access

https://ift.tt/2Gu7hW1

Modeling malicious domain name take-down dynamics: Why eCrime pays

Spring, JM; (2014) Modeling malicious domain name take-down dynamics: Why eCrime pays. In: 2013 APWG eCrime Researchers Summit. IEEE Green open access

https://ift.tt/2GhiW7d

Review of Children, Citizenship and Environment: Nurturing a Democratic Imagination in a Changing World, written by Bronwyn Hayward

Alderson, P; (2018) Review of Children, Citizenship and Environment: Nurturing a Democratic Imagination in a Changing World, written by Bronwyn Hayward. [Review]. The International Journal of Children's Rights , 26 pp. 186-188. 10.1163/15718182-02601009 .

https://ift.tt/2GrMLpd

Hurricane Risks, Health Consequences and Response Challenges for Small Island Based Populations: Observations from the 2017 Atlantic Hurricane Season

Shultz, JM; Kossin, JP; Shepherd, JM; Ransdell, JM; Walshe, R; Kelman, I; Galea, S; (2018) Hurricane Risks, Health Consequences and Response Challenges for Small Island Based Populations: Observations from the 2017 Atlantic Hurricane Season. Disaster Medicine and Public Health Preparedness (In press).

https://ift.tt/2pLqGHF

The socio-economics of cuneiform scholarship after the “end of archives”: views from Borsippa and Uruk

Robson, E; (2017) The socio-economics of cuneiform scholarship after the "end of archives": views from Borsippa and Uruk. In: Heffron, Y and Stone, A and Worthington, M, (eds.) At the Dawn of History: Ancient Near Eastern Studies in Honour of J.N. Postgate. (pp. 459-474). Eisenbrauns: Winona Lake, Indiana, United States.

https://ift.tt/2GvRENL

Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome

Sellar, R; Gale, R; Khwaja, A; Garbowski, M; Loddo, M; Stoeber, K; Williams, GH; Sellar, R; Gale, R; Khwaja, A; Garbowski, M; Loddo, M; Stoeber, K; Williams, GH; Linch, D; - view fewer (2018) Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome. British Journal of Haematology (In press).

https://ift.tt/2GhEdOs

Predicting outcome in idiopathic pulmonary fibrosis using automated CT analysis

Jacob, J; Bartholmai, B; Rajagopalan, S; van Moorsel, C; van Es, H; van Beek, F; Struik, M; ... Wells, A; + view all Jacob, J; Bartholmai, B; Rajagopalan, S; van Moorsel, C; van Es, H; van Beek, F; Struik, M; Kokosi, M; Egashira, R; Brun, AL; Nair, A; Walsh, S; Cross, G; Barnett, J; de Lauretis, A; Judge, E; Desai, S; Karwoski, R; Ourselin, S; Renzoni, E; Maher, T; Altmann, A; Wells, A; - view fewer (2018) Predicting outcome in idiopathic pulmonary fibrosis using automated CT analysis. American Journal of Respiratory and Critical Care Medicine (In press).

https://ift.tt/2GvRrtX

Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model

Khan, A; Shekh-Ahmad, T; Khalilova, A; Walker, M; Ali, AB; (2018) Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model. British Journal of Pharmacology (In press).

https://ift.tt/2GeYGDs

Callous-unemotional traits and autism

Allen, JL; Jones, A; (2018) Callous-unemotional traits and autism. Psychology Review Magazine , 23 (4)

https://ift.tt/2Gqd7bd

Ambivalent men: male dilemmas and fertility control in Senegal

Randall, SC; Mondain, N; Diagne, A; (2017) Ambivalent men: male dilemmas and fertility control in Senegal. In: Kreager, P and Bochow, A, (eds.) Fertility, Conjuncture, Difference Anthropological Approaches to the Heterogeneity of Modern Fertility Declines. (pp. 164-192). Berghahn: Oxford, United Kingdom.

https://ift.tt/2GdFMg7

Sowing the seeds of the future: Policies for financing tomorrow's innovations

Grilli, L; Mazzucato, M; Meoli, M; Scellato, G; (2018) Sowing the seeds of the future: Policies for financing tomorrow's innovations. Technological Forecasting and Social Change , 127 pp. 1-7. 10.1016/j.techfore.2017.10.021 .

https://ift.tt/2Gy1zCy

A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response

Gillissen, JJJ; Jackman, JA; Tabaei, SR; Cho, N-J; (2018) A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response. Analytical Chemistry , 90 (3) pp. 2238-2245. 10.1021/acs.analchem.7b04607 .

https://ift.tt/2pKxEgb

A Gaussian Process Model for Knowledge Propagation in Web Ontologies

Minervini, P; Damato, C; Fanizzi, N; Esposito, F; (2015) A Gaussian Process Model for Knowledge Propagation in Web Ontologies. In: (Proceedings) 2014 IEEE International Conference on Data Mining (ICDM),. (pp. pp. 929-934). IEEE Green open access

https://ift.tt/2Gv6UdT

Effect of Glucose on the Mobility of Membrane-Adhering Liposomes

Gillissen, JJJ; Tabaei, SR; Jackman, JA; Cho, N-J; (2018) Effect of Glucose on the Mobility of Membrane-Adhering Liposomes. Langmuir , 34 (1) pp. 503-511. 10.1021/acs.langmuir.7b03364 .

https://ift.tt/2pKxq8P

How to stay entangled in a world of flows: Flexible subjects and mobile knowledge in the new media industries

Knox, H; (2015) How to stay entangled in a world of flows: Flexible subjects and mobile knowledge in the new media industries. In: Flexible Capitalism: Exchange and Ambiguity at Work. (pp. 146-172). Berghahn: Oxford, United Kingdom.

https://ift.tt/2GxTI8k

The Making of a Story-Teller: Shakespeare, Hans Christian Andersen and Family Reading in the Nineteenth Century

Stougaard-Nielsen, J; (2015) The Making of a Story-Teller: Shakespeare, Hans Christian Andersen and Family Reading in the Nineteenth Century. In: (Proceedings) Shakespeare and Scandinavia: International academic conference.

https://ift.tt/2pK3YzM