Button battery removed from the stomach resulting in a missed aortoesophageal fistula – a multidisciplinary approach to rescuing a very young patient: a case report

While coins are still the most common foreign bodies swallowed by children, ingestion of batteries has become more frequent among children due to the increasing access to electronic toys and devices.

https://ift.tt/2P0Gyoz

A painless glomus tumor: a case report

Glomus tumor is a benign and vascular hamartoma that originates from the neuromyoarterial cells of the normal glomus apparatus in the reticular dermis. The etiology of glomus tumors is unknown. It usually pres...

https://ift.tt/2PF1y1b

Ideal treatment strategy for chylous mesenteric cyst: a case report

A mesenteric chylous cyst is defined as a cyst occurring in the mesentery of the gastrointestinal tract anywhere from the duodenum to the rectum and is diagnosed most often during the fifth decade of life.

https://ift.tt/2P0GsNJ

Bilateral Spontaneous Hyphemas in a Patient with Aplastic Anemia

Bilateral spontaneous hyphemas are a rare ophthalmic event. Aplastic anemia is a hematologic condition with well-documented manifestations in the posterior segment but not the anterior segment. We present a patient with aplastic anemia without obvious risk factors for hyphema who developed bilateral spontaneous hyphemas. To our knowledge, this is the first reported case of bilateral spontaneous hyphemas in a patient with aplastic anemia.
Case Rep Ophthalmol 2018;9:444–448

https://ift.tt/2J5SwaW

Detection of Candida Endophthalmitis in a Newborn Using Handheld Spectral-Domain Optical Coherence Tomography

In a newborn with candidemia, two retinal lesions were seen without external inflammatory signs or reaction in the anterior chamber or vitreous. However, handheld spectral domain-optical coherence tomography (HH SD-OCT) images show that one of the retinal lesions had a "firework display" projecting to the vitreous that was not identified in indirect ophthalmoscopy. This finding suggested a Candida endophthalmitis. HH SD-OCT findings allowed us to make an accurate diagnosis and, therefore, modified the decision-making process in the treatment of the pathology.
Case Rep Ophthalmol 2018;9:439–443

https://ift.tt/2OyWfDW

Thrombus straddling a patent foramen ovale, pulmonary embolism and paradoxical embolism: a rare trifecta

Description 

A 55-year-old male presented to the emergency room after awakening with left facial droop, left-sided weakness and garbled speech. Vitals were significant for hypotension (73/43 mm Hg) and hypothermia (35.3°C). Physical examination was significant for left facial droop, dysarthria, bilateral upper extremity strength 4/5, bilateral lower extremity strength 3/5. Laboratory tests were significant for leucocytosis of 16.9x10⁹/L thou/mcL, lactic acid 2.5 mmol/L, creatinine 3.07 mg/dL and troponin 0.07 ng/mL.

Chest X-ray revealed no acute process. Head CT revealed no acute process with old right basal ganglia and right frontal lobe infarcts. Head and neck magnetic resonance angiography (MRA) revealed no blockages or aneurysmal dilatations. Brain MRI revealed three areas of diffusion restriction in left temporal occipital lobe, compatible with acute infarcts. Tissue plasminogen activator was not given since he was outside the window. Stroke work-up was ordered, pancultures were sent, broad-spectrum antibiotics were started, and he was sent to the intensive care unit.

Transthoracic...

https://ift.tt/2J3ZE7Q

Pelvic hydatid: the great masquerader

Description 

A 52-year-old man presented with urinary frequency and occasional lower abdominal pain for 4 months. His uroflow study and postvoid residual urine were normal and his digital rectal examination had grade 2 prostatic enlargement. His urinary symptoms were attributed to benign prostatic hyperplasia, and he was prescribed tamsulosin (0.4 mg) and solifenacin (5 mg) for his symptoms. One week later he only had partial relief of symptoms, thus an ultrasound was done that showed a cystic lesion abutting the urinary bladder in the region of right iliac fossa (figure 1). A contrast-enhanced CT (CECT) scan was then done, which showed a cystic lesion (3.8x4 cm) with enhancing internal septa and peripheral wall enhancement abutting the urinary bladder (figure 2). There was no other cyst in the abdomen so a provisional diagnosis of primary pelvic peritoneal hydatid cyst was made. We then carried out a cystoscopy to...

https://ift.tt/2Oz4Wy7

Development of acquired haemophilia A in a patient treated with alemtuzumab for multiple sclerosis

This case illustrates a 36-year-old man who presented with a factor VIII (FVIII) inhibitor (acquired haemophilia A) with cutaneous bleeding and a significant thigh haematoma. No traditional risk factors for the development of a FVIII inhibitor were identified. However, previous treatment with alemtuzumab for multiple sclerosis was noted in the patient's history. Alemtuzumab is an anti-CD52 monoclonal antibody and is known to be associated with the development of a number of autoimmune conditions, with a delay in onset of these conditions as long as 5 years after the cessation of treatment. To our knowledge, there have only been three previously documented cases of a FVIII inhibitor in the setting of alemtuzumab therapy. This case adds further evidence to the current body of literature suggesting alemtuzumab as a causative agent for the development of an FVIII inhibitor.

https://ift.tt/2J2xqu0

Meningococcemia: rare but life-threatening

Description 

A previously healthy 5-month old girl, presented at the emergency department with high fever (40°C), vomiting and nasal congestion. She had no abnormalities on physical exam and was discharged home with diagnosis of a probable viral infection, after excluding urinary infection.

Ten hours later, the infant was readmitted with purpuric lesions and prostration (figure 1), rapidly presenting with labial cyanosis, capillary refill of 6 s, tachycardia, hypotension and anuria (cold shock). The patient was empirically treated with ceftriaxone and vancomycin, started inotropic and ventilator support, having been transferred to a hospital with a paediatric intensive care unit with a refractory shock, purpuric rash and disseminated intravascular coagulation (figure 2).

Figure 1

Petechiae and purpuric lesions only on the thoracoabdominal region.

Figure 2

Purpura fulminans with necrosis of extremities.

Blood workout revealed leucopenia (2.600/mm³) with neutropenia (2.00/mm³),...

https://ift.tt/2Ow59C3

Endoscopic resection of a huge orbital ethmoidal mucocele masquerading as dacryocystocele

Paranasal mucoceles are cystic masses lined with epithelium thought to result from chronic obstruction of an impaired sinus ostia. If sufficiency large, they can cause ophthalmological sequelae including diplopia, visual acuity, globe displacement as well as the rhinological symptoms of facial pain and headache. We present the case of a 57-year-old man who presented with a 1-year history of epiphora and right globe prominence with associated diplopia. Imaging demonstrated a mass located within the medial aspect of the orbit, closely associated to the lamina papyracea and nasolacrimal duct consistent with a dacryocystocele. An alternate diagnosis of an ethmoidal mucocele was considered preoperatively following rhinologist opinion. Complete endoscopic resection of the cyst was undertaken. Histopathology confirmed diagnosis of an ethmoidal mucocele. Our report highlights mucocele should be considered in patients with chronic symptoms secondary to a mass situated in the nasolacrimal duct without radiological orbital bone destruction.

https://ift.tt/2J4FXwz

Influenza A: another cause of SIADH?

The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a frequent cause of hyponatraemia. It is a dilutional hyponatraemia secondary to impaired urinary dilution in the absence of renal disease or any identifiable non-osmotic stimulus known to induce antidiuretic hormone secretion. SIADH can arise secondary to various respiratory tract infections; however, the association between SIADH and influenza A infection is described in only a few cases in the literature. The authors present a case report of influenza A that may have caused a profound SIADH-related hyponatraemia.

https://ift.tt/2OwPmmE

Verruciform xanthoma overlying inflammatory linear verrucous epidermal nevus and in broad segmental distribution

A 17-year-old woman presented with moderately itchy, non-progressive, linearly arranged verrucous plaques over dorsum of left foot since early childhood. Two years ago, she developed slowly increasing, verrucous exophytic growth in posterior most aspect of linear verrucous plaque. One year ago, she also developed multiple, linearly arranged, fleshy plaques with surface crusting over lateral aspect of right leg extending to thigh. Biopsy from both verrucous lesion on left foot and fleshy plaque on right leg showed an exophytic growth with significant papillomatosis, neutrophils in stratum corneum, acanthosis and infiltration of papillary dermis with foamy macrophages that were CD 68 positive, features compatible with verruciform xanthoma (VX). Biopsy from linear verrucous plaque over left foot was consistent with inflammatory linear verrucous epidermal nevus (ILVEN). A diagnosis of segmental VX and VX overlying ILVEN was made.

https://ift.tt/2J5rfpd

Churg-Strauss vasculitis presenting with steroid-responsive left ventricular cardiac mass

A 35-year-old black Saudi man, with a known case of bronchial asthma and allergic rhinitis since childhood, presented with joint pain and swelling, orthopnoea, paroxysmal nocturnal dyspnoea and lower extremity oedema. On examination, we found jugular venous distension, bilateral basal crepitation, wheezing and diffuse synovitis. Investigations were notable for peripheral blood eosinophilia, pericardial effusion and elongated structure in the left ventricular outflow tract on echocardiography, mediastinal and hilar lymphadenopathy and right upper lobe infiltrate on high-resolution CT scan. Pulmonary infiltrate biopsy confirmed eosinophilic vasculitis. Intracardiac mass resolved shortly after pulse steroids indicating an inflammatory mass.

https://ift.tt/2OtKwqa

Correction: Vacuum-assisted right atrial infected clot extraction due to persistent bacteraemia: a percutaneous approach for the management of right-sided endocarditis

Ahmed M, Montford JH, Lau E. Vacuum-assisted right atrial infected clot extraction due to persistent bacteraemia: a percutaneous approach for the management of rightsided endocarditis. BMJ. doi:10.1136/bcr-2018-226493.

The previous version of this manuscript contains an error in author's surname namely Jaime Hernandez Montford. It should read as:

Jaime Hernandez Montfort

instead of

Jaime Hernandez Montford

Also, the location of Baystate Medical Center should read as:

Baystate Medical Center, Springfield, MA, USA

Instead of

Baystate Medical Center, Springfield, Illinois, USA

https://ift.tt/2J1OtMG

Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease

A 69-year-old woman suffering from exophthalmos and facial pain came to us referred for aetiological diagnosis of exophthalmos. Orbital MRI showed thinned extrinsic ocular musculature, intraconal fat infiltration, retro-ocular compression and thickening of maxillary and sphenoid sinus walls. She had been suffering from diabetes insipidus for the last 7 years. During our diagnosis process, she presented signs of cardiac tamponade. Transthoracic heart ultrasound revealed large pericardial effusion and a heterogeneous mass that compressed the right ventricle. No osteosclerotic lesions on appendicular bones were present. Pericardiocentesis temporarily controlled tamponade and corticoid therapy temporarily abated exophthalmos. Pericardiectomy definitively resolved tamponade. Histological examination of pericardial tissue was conclusive of Erdheim-Chester disease. Exophthalmos responded to pegylated interferon-alpha-2a. Facial bone pain disappeared after zoledronic acid and interferon treatment. During interferon therapy, the patient suffered from a severe generalised desquamative exanthema that slowly resolved after discontinuing interferon. Diabetes insipidus remains controlled with desmopressin.

https://ift.tt/2OyRzxS

Regulation of metabolic supply and demand during B cell activation and subsequent differentiation

Takeshi Egawa | Deepta Bhattacharya

https://ift.tt/2yNoBzk

Forced oscillatory parameters in reversibility testing as predictors for chronic cough responsive to ICS/LABA

The cough guidelines recommend that asthma should always be considered as a potential etiology of chronic cough.1,2 The presence of airway hyperresponsiveness is consistent with, but not diagnostic of, cough due to mild asthma.A definitive diagnosis cannot be made until resolution of cough is achieved with specific therapy, including inhaled corticosteroid/long-acting β2 agonist (ICS/LABA) or ICS. Airway reversibility testing is often used to diagnose cough due to mild asthma; however, reversibility of forced expiratory volume in 1 second (FEV1) is smaller in mild asthma than in moderate asthma because baseline FEV1 values are normal or nearly normal in most patients with mild asthma.

https://ift.tt/2OvIeXy

Tumor necrosis factor-alpha inhibitors for the treatment of pyoderma gangrenosum not associated with inflammatory bowel diseases: a multicenter retrospective study

https://ift.tt/2Cql4e4

Use of multifilament nylon floss in onychocryptosis

https://ift.tt/2CP1dpP

Vulvar Cancer Association with Groin Hidradenitis Suppurativa: A Large, Urban, Midwestern U.S. Patient Population Study

https://ift.tt/2Cqgtsl

Hydrocolloid Dressing Application for the Treatment of Pediatric Onychodystrophies

https://ift.tt/2CP16dT

Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials

https://ift.tt/2CqgnAZ

What do Patients Undergoing Mohs Micrographic Surgery Value? Results of a Patient Values Survey based on OAS-CAHPS

https://ift.tt/2CP0VPL

Epidemiology of Nickel Sensitivity: Retrospective Cross-Sectional Analysis of North American Contact Dermatitis Group (NACDG) Data 1994-2014

Detailed analyses of trends in nickel sensitivity in North America are lacking. Clinicians should be aware of a significant increase in nickel sensitivity over time (14.3% to 20.1% from 1994 to 2014) and significant increase in current clinical relevance of reactions over time (44.1% to 51.6% from 1994 to 2014).

https://ift.tt/2Cqght7

Pumpkin Carving Alternatives | Halloween Safety Tips for Parents

Looking for safe alternatives to carving pumpkins this year? We've recruited a few helpers to demonstrate our favorite pumpkin decorating techniques that are safe for the whole family. We'll also discuss other ways to make your family's Halloween fun and safe, beyond just pumpkin carving. Happy Haunting!

The post Pumpkin Carving Alternatives | Halloween Safety Tips for Parents appeared first on ChildrensMD.

https://ift.tt/2QUJtMA

APACT & WCC 2018: Tobacco Control, Oral Cancer and the Sustainable Development Goals in the Asia-Pacific

Tobacco Control, Oral Cancer and Sustainable Development in the Asia-Pacific

https://ift.tt/2ECeR10

Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia

Viral Immunology, Ahead of Print.


https://ift.tt/2R0wRnp

The expression of MHC class II molecules on murine breast tumors delays T-cell exhaustion, expands the T-cell repertoire, and slows tumor growth

Abstract

The expression of MHC class II molecules (MHCII) on tumor cells correlates with survival and responsiveness to immunotherapy. However, the mechanisms underlying these observations are poorly defined. Using a murine breast tumor line, we showed that MHCII-expressing tumors grew more slowly than controls and recruited more functional CD4⁺ and CD8⁺ T cells. In addition, MHCII-expressing tumors contained more TCR clonotypes expanded to a larger degree than control tumors. Functional CD8⁺ T cells in tumors depended on CD4⁺ T cells. However, both CD4⁺ and CD8⁺ T cells eventually became exhausted, even in MHCII-expressing tumors. Treatment with anti-CTLA4, but not anti-PD-1 or anti-TIM-3, promoted complete eradication of MHCII-expressing tumors. These results suggest tumor cell expression of MHCII facilitates the local activation of CD4⁺ T cells, indirectly helps the activation and expansion of CD8⁺ T cells, and, in combination with the appropriate checkpoint inhibitor, promotes tumor regression.

https://ift.tt/2PDYXEJ

Association of Caffeine and Caffeinated Coffee Intake With Risk of Incident Rosacea in Women

This large cohort study of participants in the Nurses' Health Study II evaluates the association between risk of incident rosacea in women and caffeine intake, including caffeinated coffee consumption.

https://ift.tt/2RUpRJP

One More Reason to Continue Drinking Coffee—It May Be Good for Your Skin

Who does not love a study that validates one of life's habitual pleasures? Whether it is an iced latte, a double espresso, or simply a hot cup of brown liquid in the hospital cafeteria, many of us in medicine have an emotional attachment as well as a physiologic dependence on coffee.

https://ift.tt/2EtLE8w

Utility of Test Result Monitoring in Patients Taking Terbinafine or Griseofulvin for Dermatophyte Infections

This study assesses the rate and utility of monitoring laboratory test result abnormalities in adults and children taking terbinafine and griseofulvin for treatment of dermatophyte infections.

https://ift.tt/2RXJQaO

Cicatrizing Blepharoconjunctivitis During Dupilumab Treatment and an Algorithm for Its Management

This case report describes a patient who developed cicatrizing blepharoconjunctivitis while undergoing dupilumab treatment and proposes an algorithm for the management of dupilumab-associated conjunctivitis.

https://ift.tt/2EutbsG

Open-Label, Multicenter, Phase Ⅱ Study of Docetaxel and Cisplatin Combined With Nimotuzumab As First-Line Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma

Condition:   Over Survival
Intervention:   Drug: Docetaxel and Cisplatin and Nimotuzumab
Sponsor:   Sun Yat-sen University
Not yet recruiting

https://ift.tt/2yqWy9H

Phase II Study of Perioperative Immunotherapy in Patients With Advanced Non-Virally Associated Squamous Cell Carcinoma

Conditions:   Cancer;   Carcinoma;   Squamous Cell Carcinoma;   Head and Neck Cancer
Interventions:   Biological: Atezolizumab;   Biological: Emactuzumab
Sponsors:   University of California, San Francisco;   Genentech, Inc.
Not yet recruiting

https://ift.tt/2yFYSsK

Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea

Thyroid, Ahead of Print.


https://ift.tt/2yMtysa

Sequential Segmental Analysis of the Crocodilian Heart

Cook, AC; Tran, V-H; Spicer, DE; Rob, JMH; Sridharan, S; Taylor, A; Anderson, RH; Cook, AC; Tran, V-H; Spicer, DE; Rob, JMH; Sridharan, S; Taylor, A; Anderson, RH; Jensen, B; - view fewer (2017) Sequential Segmental Analysis of the Crocodilian Heart. Journal of Anatomy , 231 (4) pp. 484-499. 10.1111/joa.12661 . Green open access

https://ift.tt/2PJGqa8

Stresses and strains on the human fetal skeleton during development

Verbruggen, SW; Kainz, B; Shelmerdine, SC; Hajnal, JV; Rutherford, MA; Arthurs, OJ; Phillips, ATM; Verbruggen, SW; Kainz, B; Shelmerdine, SC; Hajnal, JV; Rutherford, MA; Arthurs, OJ; Phillips, ATM; Nowlan, NC; - view fewer (2018) Stresses and strains on the human fetal skeleton during development. Interface , 15 (138) , Article 20170593. 10.1098/rsif.2017.0593 . Green open access

https://ift.tt/2P4DibH

Constraints on off-shell Higgs boson production and the Higgs boson total width in ZZ → 4ℓ and ZZ → 2ℓ2ν final states with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... et alia, et al; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adam, L; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambler, A; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aparisi Pozo, JA; et alia, et al; - view fewer (2018) Constraints on off-shell Higgs boson production and the Higgs boson total width in ZZ → 4ℓ and ZZ → 2ℓ2ν final states with the ATLAS detector. Physics Letters B , 786 pp. 223-244. 10.1016/j.physletb.2018.09.048 . Green open access

https://ift.tt/2PFtaD5

Ssri and Snri Withdrawal Symptoms Reported on an Internet Forum

Stockmann, T; Odegbaro, D; Timimi, S; Moncrieff, J; (2018) Ssri and Snri Withdrawal Symptoms Reported on an Internet Forum. International Journal of Risk and Safety in Medicine , 29 (3-4) pp. 175-180. 10.3233/JRS-180018 . Green open access

https://ift.tt/2P1iPod

Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors

Verbruggen, SW; Kainz, B; Shelmerdine, SC; Arthurs, OJ; Hajnal, JV; Rutherford, MA; Phillips, ATM; Verbruggen, SW; Kainz, B; Shelmerdine, SC; Arthurs, OJ; Hajnal, JV; Rutherford, MA; Phillips, ATM; Nowlan, NC; - view fewer (2018) Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors. Journal of Biomechanics , 78 pp. 1-9. 10.1016/j.jbiomech.2018.07.016 . Green open access

https://ift.tt/2PFt0LZ

Informal caregiving and markers of adiposity in the UK Household Longitudinal Study

Lacey, RE; McMunn, A; Webb, E; (2018) Informal caregiving and markers of adiposity in the UK Household Longitudinal Study. Presented at: Society for Longitudinal and Lifecourse Studies: SLLS International Conference 2017, University of Stirling, Scotland, UK.

https://ift.tt/2P6LRmf

From the Editor's Desk....: December 2018

Moreau, R; Bataller, R; Berg, T; Lotersztajn, S; Zucman-Rossi, J; Jalan, R; (2018) From the Editor's Desk....: December 2018. [Editorial comment]. Journal of Hepatology (In press).

https://ift.tt/2PAnwCs

Parental Separation and Adult Psychological Distress: The Role of Material and Relational Pathways: Evidence from Two British Birth Cohorts

Lacey, RE; (2017) Parental Separation and Adult Psychological Distress: The Role of Material and Relational Pathways: Evidence from Two British Birth Cohorts. Presented at: Society for Longitudinal and Lifecourse Studies: SLLS International Conference 2017, University of Stirling, Scotland, UK.

https://ift.tt/2P624bp

Reply regarding 'Presentation to publication: institutional and individual factors'

Shelmerdine, SC; Arthurs, OJ; (2017) Reply regarding 'Presentation to publication: institutional and individual factors'. Pediatric Radiology , 47 (2) pp. 247-248. 10.1007/s00247-016-3744-2 . Green open access

https://ift.tt/2PEHGez

The Humility of Plaster

Ruggaber, K; (2018) The Humility of Plaster. Presented at: Humility of Plaster, Cambridge, UK.

https://ift.tt/2P9vgOy

Open access? Widening access to chimeric antigen receptor (CAR) therapy for ALL

Ghorashian, S; Amrolia, P; Veys, P; (2018) Open access? Widening access to chimeric antigen receptor (CAR) therapy for ALL. Experimental Hematology , 66 pp. 5-16. 10.1016/j.exphem.2018.07.002 .

https://ift.tt/2PEHwDZ

Kinetics of degradation of non-recycled and recycled contemporary paper

Coppola, F; Modelli, A; Strlic, M; Andretta, M; Scagnolari, F; (2018) Kinetics of degradation of non-recycled and recycled contemporary paper. Cellulose , 25 (9) pp. 5337-5347. 10.1007/s10570-018-1951-8 .

https://ift.tt/2P7vdTu

Extent of resection of peritumoral diffusion tensor imaging-detected abnormality as a predictor of survival in adult glioblastoma patients

Yan, J-L; van der Hoorn, A; Larkin, TJ; Boonzaier, NR; Matys, T; Price, SJ; (2017) Extent of resection of peritumoral diffusion tensor imaging-detected abnormality as a predictor of survival in adult glioblastoma patients. Journal of neurosurgery , 126 (1) pp. 234-241. 10.3171/2016.1.JNS152153 . Green open access

https://ift.tt/2PEH6gT

STACKing the odds for adolescent survival: health service factors associated with full retention in care and adherence amongst adolescents living with HIV in South Africa

Cluver, L; Pantelic, M; Toska, E; Orkin, M; Casale, M; Bungane, N; Sherr, L; (2018) STACKing the odds for adolescent survival: health service factors associated with full retention in care and adherence amongst adolescents living with HIV in South Africa. Journal of the International AIDS Society , 21 (9) , Article e25176. 10.1002/jia2.25176 . Green open access

https://ift.tt/2P7v6Y4

Numeracy skills and the numerate environment: Affordances and demands

Mallows, D; Evans, J; Yasukawa, K; Creese, B; (2017) Numeracy skills and the numerate environment: Affordances and demands. Adults Learning Mathematics: an International Journal , 12 (1) pp. 17-26. Green open access

https://ift.tt/2PEHkVh

JINGLE, a JCMT legacy survey of dust and gas for galaxy evolution studies – I. Survey overview and first results

Saintonge, A; Wilson, CD; Xiao, T; Lin, L; Hwang, HS; Tosaki, T; Bureau, M; ... Zheng, Z; + view all Saintonge, A; Wilson, CD; Xiao, T; Lin, L; Hwang, HS; Tosaki, T; Bureau, M; Cigan, PJ; Clark, CJR; Clements, DL; Looze, ID; Dharmawardena, T; Gao, Y; Gear, WK; Greenslade, J; Lamperti, I; Lee, JC; Li, C; Michałowski, MJ; Mok, A; Pan, HA; Sansom, AE; Sargent, M; Matthew, MW; Williams, T; Yang, C; Zhu, M; Accurso, G; Barmby, P; Brinks, E; Bourne, N; Brown, T; Chung, A; Chung, EJ; Cibinel, A; Coppin, K; Davies, J; Davis, TA; Eales, S; Fanciullo, L; Fang, T; Gao, Y; Glass, DHW; Gomez, HL; Greve, T; He, J; Ho, LC; Huang, F; Jeong, H; Jiang, X; Jiao, Q; Kemper, F; Kim, JH; Kim, M; Kim, T; Ko, J; Kong, X; Lacaille, K; Lacey, CG; Lee, B; Lee, JH; Lee, WK; Masters, K; Oh, SH; Papadopoulos, P; Park, C; Park, SJ; Parsons, H; Rowlands, K; Scicluna, P; Scudder, JM; Sethuram, R; Serjeant, S; Shao, Y; Sheen, YK; Shi, Y; Shim, H; Smith, CMA; Spekkens, K; Tsai, AL; Verma, A; Urquhart, S; Violino, G; Viti, S; Wake, D; Wang, J; Wouterloof, J; Yang, Y; Yim, K; Yuan, F; Zheng, Z; - view fewer (2018) JINGLE, a JCMT legacy survey of dust and gas for galaxy evolution studies – I. Survey overview and first results. Monthly Notices of the Royal Astronomical Society , 481 (3) pp. 3497-3519. 10.1093/mnras/sty2499 . Green open access

https://ift.tt/2P7v16I

Effect of Lidocaine on Local Invasion of Oral Cancer

Rozaimee, R; Leeson, R; Nomikou, N; (2018) Effect of Lidocaine on Local Invasion of Oral Cancer. Presented at: 96th General Session & Exhibition of the IADR, London, England.

https://ift.tt/2PCN2qt

Parenting, the other oldest profession in the world - a cross-sectional study of parenting and child outcomes in South Africa and Malawi

Sherr, L; Macedo, A; Cluver, LD; Meinck, F; Skeen, S; Hensels, IS; Sherr, LTS; ... Tomlinson, M; + view all Sherr, L; Macedo, A; Cluver, LD; Meinck, F; Skeen, S; Hensels, IS; Sherr, LTS; Roberts, KJ; Tomlinson, M; - view fewer (2017) Parenting, the other oldest profession in the world - a cross-sectional study of parenting and child outcomes in South Africa and Malawi. Health Psychology and Behavioral Medicine , 5 (1) pp. 145-165. 10.1080/21642850.2016.1276459 . Green open access

https://ift.tt/2P7goAc

Sharing caregiving for older adults & paid work: Couples in the UK Longitudinal Study

Lacey, RE; (2017) Sharing caregiving for older adults & paid work: Couples in the UK Longitudinal Study. Presented at: British Society for Population Studies Conference 2017, University of Liverpool, UK.

https://ift.tt/2PLFKAI

Measurement of the cross section for isolated-photon plus jet production in pp collisions at root √s=13 TeV using the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... 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Zenis, T; Zerwas, D; Zhang, D; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, M; Zhou, M; Zhou, N; Zhou, Y; Zhu, CG; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, NI; Zimmermann, C; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Zivkovic, L; Zobernig, G; Zoccoli, A; Zou, R; zur Nedden, M; Zwalinski, L; - view fewer (2018) Measurement of the cross section for isolated-photon plus jet production in pp collisions at root √s=13 TeV using the ATLAS detector. Physics Letters B , 780 pp. 578-602. 10.1016/j.physletb.2018.03.035 . Green open access

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Secukinumab is Superior to Ustekinumab in Clearing Skin in Patients with Moderate to Severe Plaque Psoriasis (16-Week CLARITY Results)

Abstract

Introduction

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate to severe plaque psoriasis. Here, we report 16-week results from CLARITY, a second head-to-head trial comparing secukinumab with ustekinumab.

Methods

In the phase 3b CLARITY study, patients were randomized 1:1 to receive subcutaneous secukinumab 300 mg or ustekinumab per label. The co-primary objectives were to demonstrate the superiority of secukinumab over ustekinumab at Week 12 in relation to the proportion of patients with (1) 90% or more improvement from baseline Psoriasis Area and Severity Index (PASI 90) and (2) a score of 0/1 (clear/almost clear) on the modified Investigator's Global Assessment (IGA mod 2011 0/1). Key secondary objectives were also assessed, as was Dermatology Life Quality Index (DLQI) 0/1 (no impact of skin disease on patients' quality of life) response. Missing values were handled by multiple imputation except for DLQI 0/1, where last observation carried forward techniques were utilized.

Results

Both co-primary objectives were met: secukinumab was superior to ustekinumab for the proportion of patients achieving a PASI 90 (66.5% vs. 47.9%) and IGA mod 2011 0/1 response (72.3% vs. 55.4%) at Week 12 (p < 0.0001). PASI 90 responses were greater with secukinumab compared to ustekinumab from as early as Week 4 (16.7% vs. 4.0%) and out to Week 16 (76.6% vs. 54.2%). Similarly, IGA mod 2011 0/1 findings were greater with secukinumab at Week 4 (26.9% vs. 7.8%) and at Week 16 (78.6% vs. 59.1%). DLQI 0/1 response rates were also greater with secukinumab compared to ustekinumab at Week 4 (33.9% vs. 18.0%), Week 12 (64.0% vs. 51.7%), and Week 16 (68.4% vs. 55.9%).

Conclusion

The results of this study confirm the superior efficacy of secukinumab over ustekinumab in treating patients with moderate to severe psoriasis.

Trial Registration

Clinicaltrials.gov Identifier, NCT02826603.

Funding

Novartis Pharma AG, Basel, Switzerland.

https://ift.tt/2NMRHV1

Les toxidermies graves sont-elles évitables ?

Publication date: Available online 16 October 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): J.-L. Schmutz

https://ift.tt/2EqpmEP

Intraoperative Hypothermia is Associated With Reduced Acute Kidney Injury After Spine Surgery Under General Anesthesia: A Retrospective Observational Study

Background: Although hypothermia is known to have protective effects against ischemic injuries, the effects of hypothermia on kidney injury have not yet been elucidated. Therefore, this study aimed to identify the association between intraoperative hypothermia and postoperative acute kidney injury (AKI) in patients who underwent spine surgery under general anesthesia. Methods: In this retrospective observational study, we analyzed the medical records of adult patients who underwent elective spine surgery between January 2010 and March 2018. Patients were classified into the normothermia group (36.5 to 37.5°C), mild hypothermia group (35 to 36.5°C), and hypothermia group (

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Cognitive Aids for the Diagnosis and Treatment of Neuroanesthetic Emergencies: Consensus Guidelines on Behalf of the Society for Neuroscience in Anesthesiology and Critical Care (SNACC) Education Committee

Cognitive aids and evidence-based checklists are frequently utilized in complex situations across many disciplines and sectors. The purpose of such aids is not simply to provide instruction so as to fulfill a task, but rather to ensure that all contingencies related to the emergency are considered and accounted for and that the task at hand is completed fully, despite possible distractions. Furthermore, utilization of a checklist enhances communication to all team members by allowing all stakeholders to know and understand exactly what is occurring, what has been accomplished, and what remains to be done. Here we present a set of evidence-based critical event cognitive aids for neuroanesthesia emergencies developed by the Society for Neuroscience in Anesthesiology and Critical Care (SNACC) Education Committee. The authors have no funding or conflicts of interest to disclose. Address correspondence to: Amie L. Hoefnagel, MD, Department of Anesthesiology, University of Florida College of Medicine—Jacksonville, 2nd Floor, Clinical Center, 655 West 8th Street, C72, Jacksonville, FL 32209 (e-mail: amie.hoefnagel@jax.ufl.edu). Received August 7, 2018 Accepted August 27, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

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Regional Versus General Anesthesia: Effect of Anesthetic Techniques on Clinical Outcome in Lumbar Spine Surgery A Prospective Randomized Controlled Trial

Background: There are only a few prospective clinical trials investigating the effects of different anesthetic techniques on clinical outcomes after lumbar spine surgery. The purpose of this study was to evaluate clinical outcomes in patients receiving general (GA) and regional anesthesia (RA) for lumbar spine surgery. Methods: This was a single-center, 2-arm, trial in which 100 patients undergoing lumbar spine surgery were randomized to receive either RA or GA (50 per group). The primary endpoint was morphine consumption during the first postoperative 48 hours. In addition, anesthesia time, transition time (defined as time from end of surgery to admission to the postoperative anesthesia care unit), visual analogue scale (VAS) for pain, and patient satisfaction at hospital discharge were recorded. Results: There was no difference in the primary endpoint (cumulative morphine consumption at 48 h) between the 2 anesthesia types. Anesthesia and transition times were significantly shorter in the RA compared with the GA group—anesthesia time 125.4±23.6 minutes for GA versus 99.4±13.5 minutes for RA, transition time 22.5 minutes for GA versus 10.0 minutes for RA (both P

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Is Running Better than Walking for Reducing Hip Joint Loads?

Purpose Knowledge of hip biomechanics during locomotion is necessary for designing optimal rehabilitation programs for hip-related conditions. The purpose of this study was to: 1) determine how lower-limb muscle contributions to the hip contact force (HCF) differed between walking and running; and 2) compare both absolute and per-unit-distance (PUD) loads at the hip during walking and running. Methods Kinematic and ground reaction force data were captured from eight healthy participants during overground walking and running at various steady-state speeds (walking: 1.50 ± 0.11 m·s−1 and 1.98 ± 0.03 m·s−1; running: 2.15 ± 0.18 m·s−1 and 3.47 ± 0.11 m·s−1). A three-dimensional musculoskeletal model was used to calculate the HCF as well as lower-limb muscular contributions to the HCF in each direction (posterior–anterior; inferior–superior; lateral–medial). The impulse of the resultant HCF was calculated as well as the PUD impulse (BW·s·m−1) and PUD force (BW·m−1). Results For both walking and running, HCF magnitude was greater during stance than swing and was largest in the inferior–superior direction and smallest in the posterior–anterior direction. Gluteus medius, iliopsoas, and gluteus maximus generated the largest contributions to the HCF during stance, whereas iliopsoas and hamstrings generated the largest contributions during swing. When comparing all locomotion conditions, the impulse of the resultant HCF was smallest for running at 2.15 m·s−1 with an average magnitude of 2.14 ± 0.31 BW·s, whereas the PUD impulse and force were smallest for running at 3.47 m·s−1 with average magnitudes of 0.95 ± 0.18 BW·s·m−1 and 1.25 ± 0.24 BW·m−1, respectively. Conclusions Hip PUD loads were lower for running at 3.47 m·s−1 compared with all other locomotion conditions because of a greater distance travelled per stride (PUD impulse) or a shorter stride duration combined with a greater distance travelled per stride (PUD force).

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Resistance Exercise Selectively Mobilizes Monocyte Subsets: Role of Polyphenols

Purpose To examine the impact of polyphenol supplementation on the recruitment, mobilization, and activation of monocyte subsets after resistance exercise. Methods Thirty-eight recreationally active males (22.1 ± 3.1 yr; 173.9 ± 7.9 cm; 77.8 ± 14.5 kg) were assigned to 28 d of polyphenol blend (PPB) supplementation, placebo (PL), or control (CON). Blood samples were obtained before (PRE) postresistance exercise, immediately (IP) postresistance exercise, 1 h (1H) postresistance exercise, 5 h (5H) postresistance exercise, 24 h (24H) postresistance exercise, and 48 h (48H) postresistance exercise (PPB/PL) or rest (CON). Fine-needle biopsies were obtained from the vastus lateralis at PRE, 1H, 5H, and 48H. Circulating concentrations of macrophage chemoattractant protein-1 (MCP-1) and fractalkine, as well as intramuscular MCP-1 were analyzed via multiplex assay. Changes in the proportions and expression of CD11b on monocyte subsets were assessed via flow cytometry. Results Circulating MCP-1 increased in PPB and PL at IP with further increases at 5H. Intramuscular MCP-1 was increased at 1H, 5H, and 48H in all groups. Classical monocyte proportions were reduced in PPB and PL at IP, and increased at 1H. Nonclassical monocytes were increased in PPB and PL at IP, whereas intermediate monocytes were increased at IP, and reduced at 1H. Intermediate monocytes were increased in PPB at 24H and 48H. CD11b expression was reduced on PPB compared with PL and CON at PRE on intermediate and nonclassical monocytes. Conclusions Resistance exercise may elicit selective mobilization of intermediate monocytes at 24H and 48H, which may be mediated by tissue damage. Additionally, polyphenol supplementation may suppress CD11b expression on monocyte subsets at rest.

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Impact of a Graded Exercise Program on V˙O2peak and Survival in Heart Failure Patients

Introduction Although exercise therapy has the potential to improve health outcomes of patients with chronic heart failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines 1 yr after cardiac rehabilitation. We aimed to assess the effects of an extended cardiac rehabilitation program with 12 months of graded exercise therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. Methods This prospective cohort study included 60 CHF patients between 2009 and 2010. The GET-RT program consisted of exercise sessions at 6 d·wk−1. Total training time of aerobic exercises increased incrementally every other week without changing exercise intensity. Resistance exercise training consisted of 8 exercises with a durable resistance band. Guidance consisted of a step-down approach from in-hospital to home-based training. Cardiopulmonary exercise tests were performed at baseline, 3, 6, and 12 months. Subsequently, patients were propensity score matched on a 1:2 ratio with controls (n = 117) from a CHF registry of patients from the same clinic receiving usual out-patient care and the incidence of all-cause mortality was compared between both groups. Results Baseline V˙O2 peak was 15.0 mL·min−1·kg−1 and significantly elevated at 3 months (+1.1 mL·min−1·kg−1 (95% CI, 0.4–1.8), 6 months (+2.9 mL·min−1·kg−1 (95% CI, 1.1–2.9) and 12 months (+2.6 mL·min−1·kg−1 (95% CI, 1.4–3.8). During 8 yr of follow-up 23 (38.3%) patients of the GET-RT program died versus 63 (53.8%) patients of the control group (P = 0.063). Conclusions The 12-month GET-RT program was associated with an improved fitness during 1-yr follow-up, whereas a tendency toward better survival rates was observed during long-term follow-up.

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Ciliated HPV-Related Carcinoma: A Diagnostic Challenge on Frozen Section

Abstract

Oropharyngeal squamous cell carcinomas associated with high risk HPV show a wide morphological spectrum, including papillary, adenosquamous, lymphoepithelioma-like and sarcomatoid. We report an interesting case of ciliated HPV-related carcinoma arising from tonsillar tissue in a 55-year-old man which was associated with HPV33. This rare variant has been described in only a handful of cases in the literature, and to our knowledge this is the first case specifically associated with HPV33. The presence of cilia is a potential diagnostic problem as it has been traditionally considered a feature of benignancy, and could pose a particular challenge on frozen section. The diagnostic challenges, differential diagnosis of this tumor and the association with HPV33 are discussed.

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The profiling of axial spondyloarthritis patient candidate to a biologic therapy: Consensus from a Delphi-panel of Italian experts

Publication date: Available online 16 October 2018

Source: Autoimmunity Reviews

Author(s): Ennio Giulio Favalli, Andrea Becciolini, Roberto Caporali, Monica Todoerti, Florenzo Iannone, Liliana Dinoia, Marco Sebastiani, Amelia Spinella, Elisa Gremese, Francesco Cianci, Fabiola Atzeni, Francesca Bandinelli, Gianfranco Ferraccioli, Giovanni Lapadula, GISEA Study Group

Abstract

Objective

The project aimed to collect expert consensus statements for the profiling of patients with axial spondyloarthritis (axSpA) candidate to biologic agents (bDMARDs) treatment, in order to better define the drivers for the best treatment choice.

Methods

The 6 more interesting topics about axSpA patient profiling were identified by the project steering committee and a panel of axSpA Italian experts. A systematic literature review (SLR) was performed for each of the selected topics according to the PICO format. Two rounds of a modified Delphi process were conducted. In the 1st round, the steering committee evaluated the results of the SLR in order to formulate statements for each topic. In the 2nd round, the experts panel discussed, rephrased when needed, and voted the level of agreement (on a 5-point Likert-type scale) for each statement. Consensus was defined as ≥66% agreement.

Results

The topics selected for the analysis were the differential efficacy of available bDMARDs on enthesitis/dactylitis, uveitis, radiographic progression and cardiovascular involvement, and the clinical response in non radiographic-axSpA and in patients receiving a second-line bDMARD. The Delphi rounds formulated 19 statements, all reaching the defined level of consensus in a second round including 25 rheumatologists highly skilled in the management of axSpA.

Conclusion

Identified consensus statements can help clinicians to apply to routine-care settings the results from clinical studies and international recommendations, providing a guide for individualization of treatment strategy in axSpA patients.

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The styloglossus muscle: A critical landmark in onclogy and mandibular preservation surgery for squamous cell carcinoma of the lateral oropharynx

Publication date: Available online 16 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): O. Laccourreye, R.K. Orosco, F. Rubin, F.C. Holsinger

Abstract

Goal

To document the role of the styloglossus muscle (SG) in the oncologic staging and mandibular preservation surgery for squamous cell carcinoma of the lateral oropharynx (SCCLO).

Method

Based on a search conducted within the Pubmed, Embase, and Cochrane databases, using the key words SG muscle, parapharyngeal space and oropharynx, the authors discuss the embryology, physiology, anatomy and radiology of this muscle as well as its role in the oncologic staging and mandibular preservation surgery of SCCLO.

Results

The most specific radiologic exam to evaluate the involvement of SG muscle in SCCLO is magnetic resonance imaging (MRI). Radiologic invasion of the SG muscle, at the time of MRI, leads to reclassify as T4a many tumors considered as T1-3 at the time of clinical and/or on computerized tomography evaluation. This must lead to extreme care when comparing oncologic results from series published prior and after the MRI era. When transoral resection of the SG muscle is advocated for SCCLO, one must know that this maneuver brings numerous arterial and venous structures within the operative field. If difficulties to achieve safe margins of resection and/or to control bleeding are encountered, a simple trans cervical maneuver described herein is most useful.

Conclusion

The importance of the SG muscle should be emphasized as a touchstone for staging and surgeon's guide to mandibular preservation surgery of SCCLO. The various approaches allowing the control of this muscle and its vascular environment must be taught at the time of initial training.

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The speech perception after cochlear implantation: The hearing gain difference according to the implant systems is important?

Publication date: Available online 16 October 2018

Source: Auris Nasus Larynx

Author(s): Jeong Hun Jang, Hyoung Ah Mun, Oak-Sung Choo, Hun Yi Park, Yun-Hoon Choung

Abstract

Objective

The outcome of cochlear implantation (CI) is affected by various factors, including the manufacturer of the device. We validated the factors contributing to postoperative performance and evaluated the influence of different company devices on pure tone thresholds and postoperative performance.

Methods

Our study included 56 postlingually deaf adults who underwent CI between June 2005 and March 2016. The ears were divided into groups according to the implant manufacturer: A (n = 32 ears) and B (n = 24 ears) groups. The prognostic factors for CI outcome were evaluated using speech perception at 3, 6 and 12 months postoperatively and compared across devices.

Results

The duration of hearing aid use, age at CI, and mean pure tone threshold with the implant were correlated with postoperative speech perception. The mean pure tone thresholds with the implant (averages of 0.25, 0.5, 1, 2, 4 and 6 kHz) were 27.9 ± 3.7 dB HL in the group A and 33.5 ± 5.6 dB HL in the group B (P < 0.01). The open-set monosyllabic word, open-set disyllabic word and open-set sentence scores were not significantly different between the groups at 3, 6 and 12 months postoperatively.

Conclusion

The mean pure tone threshold with implant differed between the devices; however, no device-related effect on postoperative performance was observed. Additional multifactorial analyses are needed to clarify the relationship between free-field pure tone threshold with implant and postoperative speech perception.

https://ift.tt/2CSku9G

Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour

Publication date: December 2018

Source: Oral Oncology, Volume 87

Author(s): Justin A. Bishop, William H. Westra

Abstract

Human papillomavirus (HPV) is well established as a causative factor in most squamous cell carcinomas of the oropharynx (OPSCC). Indeed, a growing awareness over the past two decades that HPV-OPSCC is a distinct form of head and neck cancer has had a profound impact on diagnostic and clinical practices. The sinonasal tract is a second anatomic "hot spot" for HPV-related head and neck carcinomas, but certain pathologic features and the clinical behavior of HPV-related carcinomas at this site remain unclear. The enigmatic nature of HPV-positive sinonasal carcinomas is especially true for an emerging form recently designated as HPV-related multiphenotypic sinonasal carcinoma (HMSC). HMSC has come to the attention of the pathology community largely owing to its highly unusual microscopic appearance: it exhibits mixed salivary gland (e.g. adenoid cystic carcinoma) and squamous differentiation. At the same time, HMSC is largely unknown by the clinical community despite an unexpected clinical behavior that could affect therapy. HMSC is characterized by high grade histologic features, locally destructive growth, advanced T stage, and a propensity for local recurrence; and yet it appears to have little potential for metastatic spread or lethal behavior. This review will describe the unique pathologic features of HMSC, discuss its distinction from adenoid cystic carcinoma and squamous cell carcinoma, and draw attention to a behavior that departs from the expected clinical course of most high grade carcinomas of the head and neck.

https://ift.tt/2J1TuF7

Immunosuppression for immunodeficiency- getting smarter

Publication date: Available online 17 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Duan Lucy, Grunebaum Eyal

https://ift.tt/2P4riXH

RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization

Publication date: Available online 17 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Norimasa Tamehiro, Kyoko Nishida, Yu Sugita, Kunihiro Hayakawa, Hiroyo Oda, Takeshi Nitta, Miwa Nakano, Akiko Nishioka, Reiko Yanobu-Takanashi, Motohito Goto, Tadashi Okamura, Reiko Adachi, Kazunari Kondo, Akimichi Morita, Harumi Suzuki

Abstract

Background

RhoH is a membrane-bound adaptor protein involved in proximal TCR signaling. Therefore, RhoH plays critical roles in the differentiation of T cells, however the function of RhoH in effecter phase of T cell response have not been fully characterized.

Objective

To explore the role of RhoH in inflammatory immune responses, we investigated the involvement of RhoH in the pathogenesis of psoriasis.

Method

We analyzed effector T cell and systemic inflammation in wild-type and RhoH-null mice. RhoH expression in T cells in human PBMC was quantified by RT-PCR.

Results

RhoH deficiency in mice induced T_H17 polarization during effector T cell differentiation, thereby inducing psoriasis-like chronic dermatitis. Ubr5 and nr2f6 expression levels decreased in RhoH-deficient T cells, resulting in increased protein levels and DNA binding activity of RORγt. The consequential increase in IL-17 and IL-22 production induced T cells to differentiate into T_H17 cells. Furthermore, IL-22BP/Fc chimeric protein reduced psoriatic inflammation in RhoH deficient mice. Expression of RhoH in T cells was lower in psoriatic patients with much severe symptoms.

Conclusion

Our results indicated that RhoH inhibits T_H17 differentiation and thereby plays a role in the pathogenesis of psoriasis. Additionally, IL-22BP has therapeutic potential for the treatment of psoriasis.

Graphical abstract

https://ift.tt/2PBXiPO

Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency

Publication date: Available online 17 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Jan Dudeck, Julia Froebel, Johanna Kotrba, Christian H.K. Lehmann, Diana Dudziak, Stephan Speier, Sergei A. Nedospasov, Burkhart Schraven, Anne Dudeck

ABSTRACT

Background

Mast cells (MCs) are best known as key effector cells of allergic reactions but they also play an important role in host defense against pathogens. Despite increasing evidence for a critical impact of MCs on adaptive immunity, the underlying mechanisms are poorly understood.

Objective

Here, we monitored MC intercellular communication with dendritic cells (DCs), MC activation and degranulation and tracked the fate of exocytosed MC granules during skin inflammation.

Methods

Using a strategy to stain intracellular MC granules in vivo we tracked the MC granules fate following skin inflammation induced MC degranulation. Further, exogenous MC granules were applied to MC-deficient mice by intradermal injection. MC granule effects on DC functionality and adaptive immune responses in vivo were assessed by combining intravital multiphoton microscopy with flow cytometry and functional assays.

Results

We demonstrate that dermal DCs engulf the intact granules exocytosed by MCs upon skin inflammation. Subsequently, the engulfed MC granules are actively shuttled to skin-draining lymph nodes (LNs) and finally degraded inside DCs within the lymphoid tissue. Most importantly, MC-granule uptake promotes DC maturation and migration to skin-draining LNs, partially via MC-derived TNF, and boosts their T cell priming efficiency. Surprisingly, exogenous MC granules alone are sufficient to induce a prominent DC activation and T cell responses.

Conclusion

Our study highlights a unique feature of peripheral MCs to impact on lymphoid tissue borne adaptive immunity over distance by modifying DC functionality via the delivery of granule-stored mediators.

Graphical abstract

https://ift.tt/2P332oN

Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)

Publication date: Available online 16 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Katherine N. Cahill, Katherine Murphy, Joseph Singer, Elliot Israel, Joshua A. Boyce, Tanya M. Laidlaw

https://ift.tt/2PAvStH

In Utero Diagnoses of Strikingly Similar Presentations of Complete Atrioventricular Septal Defects in a Pair of Dizygotic Twins Concordant for Trisomy 21

Trisomy 21, or Down syndrome (DS), is a genetic disorder affecting approximately 1 in 500–750 live births. The prevalence of DS has increased over the past two decades, correlating with a rise in the proportion of pregnancies complicated by advanced maternal age. There is also a correlation between advanced maternal age and dizygotic twinning rates. There is an increased risk of at least one twin being affected in dizygotic pregnancies compared to singletons. However, despite this greater relative risk, reports of concordance of DS in both dizygotic twins are very rare. Congenital heart disease (CHD) occurs in roughly 40% of individuals with DS, but there can be considerable phenotypic variation. The most common, atrioventricular septal defect accounts for only 40% of CHD seen in DS. There is also a higher incidence of CHD in twins, but also with a low incidence of concordance. There have been only five reported cases of concordant DS in dizygotic twins with confirmed chromosomal analyses; none of which describe concordant congenital heart disease. Here, we describe an unusual case of dizygotic twins of differing genders concordant for both Down syndrome and congenital heart disease of a strikingly similar presentation.

https://ift.tt/2OrTcNP

Correction to: Abstracts

In Poster Sessions, the author name G. Khlestova was incorrectly presented as 'K. Galina' in the authorship group for Abstract PS-18-017 (page S151). The name has been corrected in the authorship group shown above.

https://ift.tt/2QQPcmC

Ciliated HPV-Related Carcinoma: A Diagnostic Challenge on Frozen Section

Abstract

Oropharyngeal squamous cell carcinomas associated with high risk HPV show a wide morphological spectrum, including papillary, adenosquamous, lymphoepithelioma-like and sarcomatoid. We report an interesting case of ciliated HPV-related carcinoma arising from tonsillar tissue in a 55-year-old man which was associated with HPV33. This rare variant has been described in only a handful of cases in the literature, and to our knowledge this is the first case specifically associated with HPV33. The presence of cilia is a potential diagnostic problem as it has been traditionally considered a feature of benignancy, and could pose a particular challenge on frozen section. The diagnostic challenges, differential diagnosis of this tumor and the association with HPV33 are discussed.

https://ift.tt/2PDdVuB

RecordDNA: In the digital era what is the concept of the record and what implications are there for the usability of the future the evidence base?

Lomas, EJ; McLeod, J; (2018) RecordDNA: In the digital era what is the concept of the record and what implications are there for the usability of the future the evidence base? ARC: Records Management and Information Governance (In press).

https://ift.tt/2AeP8Yi

On the quality evaluation of behavioural models for building performance applications

Mahdavi, A; Tahmasebi, F; (2016) On the quality evaluation of behavioural models for building performance applications. Journal of Building Performance Simulation , 10 (5-6) pp. 554-564. 10.1080/19401493.2016.1230148 . Green open access

https://ift.tt/2QU9jAA

Association of MAPT haplotype‐tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: A preliminary study in a Croatian cohort

Babić Leko, M; Willumsen, N; Nickolac Perkovic, M; Klepac, N; Borovečki, F; Hof, P; Sonicki, Z; ... Šimić, G; + view all Babić Leko, M; Willumsen, N; Nickolac Perkovic, M; Klepac, N; Borovečki, F; Hof, P; Sonicki, Z; Pivac, N; de Silva, R; Šimić, G; - view fewer (2018) Association of MAPT haplotype‐tagging polymorphisms with cerebrospinal fluid biomarkers of Alzheimer's disease: A preliminary study in a Croatian cohort. Brain and Behavior 10.1002/brb3.1128 . (In press). Green open access

https://ift.tt/2AfcEEx

Biparty Decision Theory for Dialogical Argumentation

Hadoux, E; Hunter, A; Polberg, S; (2018) Biparty Decision Theory for Dialogical Argumentation. In: Modgil, Sanjay and Budzynska, Katarzyna and Lawrence, John, (eds.) Computational Models of Argument. Proceedings of COMMA 2018. (pp. pp. 233-240). IOS Press: Amsterdam, Netherlands. Green open access

https://ift.tt/2QZbvqv

Esaú E Jacob E Memorial De Aires: Manuscritos Que Viajam

Silva, ACS; (2019) Esaú E Jacob E Memorial De Aires: Manuscritos Que Viajam. Machado de Assis em Linha : Revista Eletrônica de Estudos Machadianos (In press).

https://ift.tt/2AeYCTK

Usage of Purchased Self-tests for Hiv Infections Among Migrants Living in the Uk, France and the Netherlands: a Cross-sectional Study

Bil, JP; Prins, M; Fakoya, I; Volny-Anne, A; Burns, F; Zuure, FR; (2018) Usage of Purchased Self-tests for Hiv Infections Among Migrants Living in the Uk, France and the Netherlands: a Cross-sectional Study. Sexually Transmitted Infections 10.1136/sextrans-2018-053583 . (In press). Green open access

https://ift.tt/2QSPDgj

Chatbot Design for Argument Harvesting

Chalaguine, LA; Hunter, A; (2018) Chatbot Design for Argument Harvesting. In: Modgil, Sanjay and Budzynska, Katarzyna and Lawrence, John, (eds.) Computational Models of Argument. Proceedings of COMMA 2018. (pp. pp. 457-458). IOS Press: Amsterdam, Netherlands. Green open access

https://ift.tt/2AeORoe

Arginine Side-Chain Hydrogen Exchange: Quantifying Arginine Side-Chain Interactions in Solution

Mackenzie, HW; Flemming Hansen, D; (2018) Arginine Side-Chain Hydrogen Exchange: Quantifying Arginine Side-Chain Interactions in Solution. ChemPhysChem 10.1002/cphc.201800598 . (In press). Green open access

https://ift.tt/2QWhood

Identification of C-Terminal Binding Protein 1 as a Novel NMDA Receptor Interactor

Cousins, SL; Stephenson, FA; (2018) Identification of C-Terminal Binding Protein 1 as a Novel NMDA Receptor Interactor. Neurochemical Research 10.1007/s11064-018-2633-5 . (In press). Green open access

https://ift.tt/2AeyFUd

A preliminary study of representing the inter-occupant diversity in occupant modelling

O'Brien, W; Gunay, HB; Tahmasebi, F; Mahdavi, A; (2016) A preliminary study of representing the inter-occupant diversity in occupant modelling. Journal of Building Performance Simulation , 10 (5-6) pp. 509-526. 10.1080/19401493.2016.1261943 . Green open access

https://ift.tt/2QWvsOG

Children, Time Allocation, and Consumption Insurance

Blundell, R; Pistaferri, L; Saporta-Eksten, I; (2018) Children, Time Allocation, and Consumption Insurance. Journal of Political Economy , 126 (S1) S73-S115. 10.1086/698752 .

https://ift.tt/2AeQjHg

Dynamic Prognostication in Critically Ill Cirrhotic Patients With Multiorgan Failure in ICUs in Europe and North America: A Multicenter Analysis

Karvellas, CJ; Garcia-Lopez, E; Fernandez, J; Saliba, F; Sy, E; Jalan, R; Pavesi, M; ... Chronic Liver Failure Consortium and European Foundation for the, ; + view all Karvellas, CJ; Garcia-Lopez, E; Fernandez, J; Saliba, F; Sy, E; Jalan, R; Pavesi, M; Gustot, T; Ronco, JJ; Arroyo, V; Chronic Liver Failure Consortium and European Foundation for the, ; - view fewer (2018) Dynamic Prognostication in Critically Ill Cirrhotic Patients With Multiorgan Failure in ICUs in Europe and North America: A Multicenter Analysis. Critical Care Medicine 10.1097/CCM.0000000000003369 .

https://ift.tt/2QWhaxn

Behavioral and Neural Signatures of Reduced Updating of Alternative Options in Alcohol-Dependent Patients during Flexible Decision-Making

Reiter, AMF; Deserno, L; Kallert, T; Heinze, H-J; Heinz, A; Schlagenhauf, F; (2016) Behavioral and Neural Signatures of Reduced Updating of Alternative Options in Alcohol-Dependent Patients during Flexible Decision-Making. Journal of Neuroscience , 36 (43) pp. 10935-10948. 10.1523/JNEUROSCI.4322-15.2016 . Green open access

https://ift.tt/2AggEEW

Confinement Facilitated Protein Stabilization As Investigated by Small-Angle Neutron Scattering

Siefker, J; Biehl, R; Kruteva, M; Feoktystov, A; Coppens, M-O; (2018) Confinement Facilitated Protein Stabilization As Investigated by Small-Angle Neutron Scattering. Journal of the American Chemical Society , 140 (40) pp. 12720-12733. 10.1021/jacs.8b08454 . Green open access

https://ift.tt/2QWh0Gh

Data‐driven multi‐objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications

Konstantinidis, S; Welsh, JP; Titchener-Hooker, NJ; Roush, DJ; Velayudhan, A; (2018) Data‐driven multi‐objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications. Biotechnology Progress 10.1002/btpr.2673 . (In press). Green open access

https://ift.tt/2AeNLJt

Multiscale tomographic analysis of the thermal failure of Na-Ion batteries

Robinson, JB; Heenan, TMM; Jervis, JR; Tan, C; Kendrick, E; Brett, DJL; Shearing, PR; (2018) Multiscale tomographic analysis of the thermal failure of Na-Ion batteries. Journal of Power Sources , 400 pp. 360-368. 10.1016/j.jpowsour.2018.07.098 .

https://ift.tt/2QWgSqh

Fast spectrophotometry of WD1145+017

Izquierdo, P; Rodríguez-Gil, P; Gänsicke, BT; Mustill, AJ; Toloza, O; Tremblay, PE; Wyatt, M; ... Zwart, SP; + view all Izquierdo, P; Rodríguez-Gil, P; Gänsicke, BT; Mustill, AJ; Toloza, O; Tremblay, PE; Wyatt, M; Chote, P; Eggl, S; Farihi, J; Koester, D; Lyra, W; Manser, CJ; Marsh, TR; Pallé, E; Raddi, R; Veras, D; Villaver, E; Zwart, SP; - view fewer (2018) Fast spectrophotometry of WD1145+017. Monthly Notices of the Royal Astronomical Society , 481 (1) pp. 703-714. 10.1093/mnras/sty2315 . (In press). Green open access

https://ift.tt/2AeNE0v

Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis

Welton, NJ; McAleenan, A; Thom, HHZ; Davies, P; Hollingworth, W; Higgins, JPT; Okoli, G; ... Sofat, R; + view all Welton, NJ; McAleenan, A; Thom, HHZ; Davies, P; Hollingworth, W; Higgins, JPT; Okoli, G; Sterne, JAC; Feder, G; Eaton, D; Hingorani, A; Fawsitt, C; Lobban, T; Bryden, P; Richards, A; Sofat, R; - view fewer (2017) Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis. Health Technology Assessment , 21 (29) 10.3310/hta21290 . Green open access

https://ift.tt/2QQqXoK

Ciliated HPV-Related Carcinoma: A Diagnostic Challenge on Frozen Section

Abstract

Oropharyngeal squamous cell carcinomas associated with high risk HPV show a wide morphological spectrum, including papillary, adenosquamous, lymphoepithelioma-like and sarcomatoid. We report an interesting case of ciliated HPV-related carcinoma arising from tonsillar tissue in a 55-year-old man which was associated with HPV33. This rare variant has been described in only a handful of cases in the literature, and to our knowledge this is the first case specifically associated with HPV33. The presence of cilia is a potential diagnostic problem as it has been traditionally considered a feature of benignancy, and could pose a particular challenge on frozen section. The diagnostic challenges, differential diagnosis of this tumor and the association with HPV33 are discussed.

https://ift.tt/2PDdVuB

Anti-neutrophil cytoplasmic antibody-associated hypertrophic cranial pachymeningitis and otitis media: a review of literature

Abstract

Background and objective

It has been recognized that anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides may lead to hypertrophic pachymeningitis (HP) or intractable otitis media (OM). To our knowledge, few cases of coexistent ANCA-related HP and OM have been described previously. To increase awareness of this disease, we reviewed the literature describing patients with HP and intractable OM in a population with AAV to guide clinical decision making for otolaryngologists.

Methods

 PubMed was searched with the following terms: ANCA-associated vasculitis, otitis media, and hypertrophic pachymeningitis. Only patients with concomitant AAV, OM and HP were considered and included in this review.

Results

A total of 243 articles were reviewed, and of these, 6 met inclusion criteria. Headache, cranial polyneuropathy, and intractable OM with effusion or granulation were common. Serum MPO–ANCA positivity was most common in Asian patients. Almost all patients had dural mater thickening on gadolinium-enhanced magnetic resonance imaging of the brain. Corticosteroids plus an immunosuppressant was more effective and most patients had improved hearing after treatment, but approximately 50% of subjects had disease relapse.

Conclusion

In this review, we summarized the current knowledge on the clinical features, diagnosis, treatment, and pathogenesis of this disease. We should carefully detect the potential cases of ANCA-related HP and OM in patients with intractable OM, HP, or AAV, and make the optimal treatment plan to avoid long-term neurological complications and irreversible hearing loss. Furthermore, due to an increased possibility of relapse, close follow-up, including a hearing test, ANCA titers, imaging examination, and detection of toxic and side effects of immunosuppressive therapy, are necessary.

https://ift.tt/2RWYwql