Case 16-2018: A 45-Year-Old Man with Fever, Thrombocytopenia, and Elevated Aminotransferase Levels

Presentation of Case. Dr. Alyssa Sclafani (Medicine): A 45-year-old man presented to the emergency department of this hospital during the summer with fever, thrombocytopenia, and elevated aminotransferase levels. Three weeks before presentation, fever occurred (with temperatures as high as 40.0°C),…

https://ift.tt/2GJonvp

Evolution of pituitary surgery in a tertiary centre

Clinical Otolaryngology, EarlyView.


https://ift.tt/2koKvCd

Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2LnHPBc

Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2xe9gKC

Chronic Urticaria: Comparisons of US, European, and Asian Guidelines

Abstract

Purpose of Review

Chronic urticaria is a common dermatological condition that has significant impact on quality of life. Multiple international societies have published guidelines, and although these guidelines generally agree on the definition of urticaria, as well as approach to diagnosis and management, there have been notable differences to date. These differences have been reconciled by the recent publication of the 2017 revision and update published by the EAACI/GA2LEN/EDF/WAO.

Recent Findings

The 2017 revision and update to the guidelines for chronic urticaria are the most comprehensive consensus document to date, and reconcile previously existing differences between the US, European, and Asian guidelines.

Summary

The purpose of our review is to present basic background on urticaria and discuss classification, diagnosis, and most importantly, management. We present differences from previous US, European, and Asian guidelines and reconcile the previous differences by summarizing the 2017 revision and update published by the EAACI/GA2LEN/EDF/WAO.

https://ift.tt/2IGR028

FACE‐Q Skin Cancer Module for measuring patient‐reported outcomes following facial skin cancer surgery

British Journal of Dermatology, EarlyView.


https://ift.tt/2LqBepR

Chronic Urticaria: Comparisons of US, European, and Asian Guidelines

Abstract

Purpose of Review

Chronic urticaria is a common dermatological condition that has significant impact on quality of life. Multiple international societies have published guidelines, and although these guidelines generally agree on the definition of urticaria, as well as approach to diagnosis and management, there have been notable differences to date. These differences have been reconciled by the recent publication of the 2017 revision and update published by the EAACI/GA2LEN/EDF/WAO.

Recent Findings

The 2017 revision and update to the guidelines for chronic urticaria are the most comprehensive consensus document to date, and reconcile previously existing differences between the US, European, and Asian guidelines.

Summary

The purpose of our review is to present basic background on urticaria and discuss classification, diagnosis, and most importantly, management. We present differences from previous US, European, and Asian guidelines and reconcile the previous differences by summarizing the 2017 revision and update published by the EAACI/GA2LEN/EDF/WAO.

https://ift.tt/2IGR028

Bullous pemphigoid complicated by necrotising fasciitis successfully treated with systemic corticosteroids and antibiotics in combination with i.v. immunoglobulin

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2IFuhDv

Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2GJm1g1

Prediction of skin anti‐aging clinical benefits of an association of ingredients from marine and maritime origins: Ex vivo evaluation using a label‐free quantitative proteomic and customized data processing approach

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2x7VNEf

A prospective observational study of pigmented naevi changes in psoriasis patients on biologic therapy

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2J4GC3x

Sublingual immunotherapy for pediatric allergic conjunctivitis: a meta‐analysis of randomized controlled trials

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2s9C5SG

Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2J6w8Rn

Comparison of outcomes following culture‐directed vs non–culture‐directed antibiotics in treatment of acute exacerbations of chronic rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2xawtO4

Evolving patterns in the diagnosis and management of allergy‐mediated disorders

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2kmhG9L

Serum zonulin is associated with presence and severity of atopic dermatitis in children, independent of total IgE and eosinophil

Clinical &Experimental Allergy, EarlyView.


https://ift.tt/2LoDTA4

Acute generalized exanthematous pustulosis due to terbinafine

Dermatologic Therapy, EarlyView.


https://ift.tt/2KRnrrh

The genome sequence of a SNP type 3K strain of Mycobacterium leprae isolated from a seventh‐century Hungarian case of lepromatous leprosy

International Journal of Osteoarchaeology, EarlyView.


https://ift.tt/2s9xTlU

A probable example of cranial dysraphism from New Orleans, Louisiana

International Journal of Osteoarchaeology, EarlyView.


https://ift.tt/2IIurKo

Precision medicine

Marcio Nakanishi
Braz J Otorhinolaryngol.2018;84:263-4

Texto Completo - PDF

https://ift.tt/2xdFyp4

How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel

Otávio Bejzman Piltcher, Eduardo Macoto Kosugi, Eulalia Sakano, Olavo Mion, José Ricardo Gurgel Testa, Fabrizio Ricci Romano, Marco Cesar Jorge Santos, Renata Cantisani Di Francesco, Edson Ibrahim Mitre, Thiago Freire Pinto Bezerra, Renato Roithmann, Francini Greco Padua, Fabiana Cardoso Pereira Valera, José Faibes Lubianca Neto, Leonardo Conrado Barbosa Sá, Shirley Shizue Nagata Pignatari, Melissa Ameloti Gomes Avelino, Juliana Alves de Souza Caixeta, Wilma Terezinha Anselmo‐Lima, Edwin Tamashiro
Braz J Otorhinolaryngol.2018;84:265-79

Resume - Texto Completo - PDF

https://ift.tt/2IJBvGo

Effects of distractors on upright balance performance in school‐aged children with attention deficit hyperactivity disorder, preliminary study

Fatma Esen Aydinli, Tuna Çak, Meltem Çiğdem Kirazli, Betül Çiçek Çinar, Alev Pektaş, Ebru Kültür Çengel, Songül Aksoy
Braz J Otorhinolaryngol.2018;84:280-9

Resume - Texto Completo - PDF

https://ift.tt/2IIhDiS

Breaking paradigms in severe epistaxis: the importance of looking for the S‐point

Eduardo Macoto Kosugi, Leonardo Balsalobre, João Mangussi‐Gomes, Miguel Soares Tepedino, Daniel Marcus San‐da‐Silva, Erika Mucciolo Cabernite, Diego Hermann, Aldo Cassol Stamm
Braz J Otorhinolaryngol.2018;84:290-7

Resume - Texto Completo - PDF

https://ift.tt/2LpDjlY

Obstructive sleep apnea is associated with increased QT corrected interval dispersion: the effects of continuous positive airway pressure

Nagihan Bilal, Nursel Dikmen, Fulsen Bozkus, Aylin Sungur, Selman Sarica, Israfil Orhan, Anil Samur
Braz J Otorhinolaryngol.2018;84:298-304

Resume - Texto Completo - PDF

https://ift.tt/2IJsbhZ

Peritonsillar and deep neck infections: a review of 330 cases

Paula Martínez Pascual, Paloma Pinacho Martinez, Eviatar Friedlander, Carlos Martin Oviedo, Bartolome Scola Yurrita
Braz J Otorhinolaryngol.2018;84:305-10

Resume - Texto Completo - PDF

https://ift.tt/2LpD6iG

Nasal mucociliary transportability of male and female smokers

Juliana Souza Uzeloto, Dionei Ramos, Ana Paula C.F. Freire, Diego G.D. Christofaro, Ercy Mara C. Ramos
Braz J Otorhinolaryngol.2018;84:311-7

Resume - Texto Completo - PDF

https://ift.tt/2ILaDlz

Comparison between clinical and audiological results of tympanoplasty with modified sandwich technique and underlay technique

Sanjana Vijay Nemade, Kiran Jaywant Shinde, Chetana Shivadas Naik, Haris Qadri
Braz J Otorhinolaryngol.2018;84:318-23

Resume - Texto Completo - PDF

https://ift.tt/2LrhUZu

Retrospective analysis of skin complications related to bone‐anchored hearing aid implant: association with surgical technique, quality of life, and audiological benefit

Daniel Peñaranda, Juan Manuel Garcia, Maria Leonor Aparicio, Felipe Montes, Clemencia Barón, Roberto C. Jiménez, Augusto Peñaranda
Braz J Otorhinolaryngol.2018;84:324-31

Resume - Texto Completo - PDF

https://ift.tt/2x4mny9

Ototoxicity of boric acid powder in a rat animal model

Murat Salihoglu, Salim Dogru, Enver Cesmeci, Halil Caliskan, Onuralp Kurt, Zafer Kuçukodaci, Atila Gungor
Braz J Otorhinolaryngol.2018;84:332-7

Resume - Texto Completo - PDF

https://ift.tt/2LpChGC

The analysis of expression of p16 protein in group of 53 patients treated for sinonasal inverted papilloma

Roland Zydroń, Andrzej Marszałek, Magdalena Bodnar, Paweł Kosikowski, Grażyna Greczka, Małgorzata Wierzbicka
Braz J Otorhinolaryngol.2018;84:338-43

Resume - Texto Completo - PDF

https://ift.tt/2ILasGV

Translation and adaptation of the Radiotherapy Edema Rating Scale to Brazilian Portuguese

Débora dos Santos Queija, Lica Arakawa‐Sugueno, Bruna Mello Chamma, Marco Aurélio Vamondes Kulcsar, Rogério Aparecido Dedivitis
Braz J Otorhinolaryngol.2018;84:344-50

Resume - Texto Completo - PDF

https://ift.tt/2IGAyPq

Evaluation of pre‐ and post‐pyriform plasty nasal airflow

Oscimar Benedito Sofia, Ney P. Castro Neto, Fernando S. Katsutani, Edson I. Mitre, José E. Dolci
Braz J Otorhinolaryngol.2018;84:351-9

Resume - Texto Completo - PDF

https://ift.tt/2x5TMIT

Hearing in Noise Test, HINT‐Brazil, in normal‐hearing children

Carolina Lino Novelli, Nádia Giulian de Carvalho, Maria Francisca Colella‐Santos
Braz J Otorhinolaryngol.2018;84:360-7

Resume - Texto Completo - PDF

https://ift.tt/2IElrWp

Effect of antioxidant supplementation on the auditory threshold in sensorineural hearing loss: a meta‐analysis

Maria Eduarda Di Cavalcanti Alves de Souza, Klinger Vagner Teixeira da Costa, Paulo Augusto Vitorino, Nassib Bezerra Bueno, Pedro de Lemos Menezes
Braz J Otorhinolaryngol.2018;84:368-80

Resume - Texto Completo - PDF

https://ift.tt/2ILagYd

Effect of caffeine on vestibular evoked myogenic potential: a systematic review with meta‐analysis

Maria Eduarda Di Cavalcanti Alves de Souza, Klinger Vagner Teixeira da Costa, Pedro de Lemos Menezes
Braz J Otorhinolaryngol.2018;84:381-8

Resume - Texto Completo - PDF

https://ift.tt/2IHCbMu

Undifferentiated high‐grade pleomorphic sarcoma of ethmoid sinus: a case report and literature review

Yupeng Zhu, Dapeng Hao, Xiaoyan Tang, Lei Sun
Braz J Otorhinolaryngol.2018;84:389-92

Texto Completo - PDF

https://ift.tt/2IGJr7u

Genomic profile of a squamous cell carcinoma ex pleomorphic adenoma compared to a head and neck squamous cell carcinoma

Fernanda Viviane Mariano, Luis Fernando Vidal Saccomani, Karina Giovanetti, André Del Negro, Luiz Paulo Kowalski, Ana Cristina Victorino Krepischi, Albina Altemani
Braz J Otorhinolaryngol.2018;84:393-7

Texto Completo - PDF

https://ift.tt/2IJlvEJ

Unusual coexisting thyroglossal duct cyst and second branchial cleft fistula in an adult

Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul Lim
Braz J Otorhinolaryngol.2018;84:398-9

Texto Completo - PDF

https://ift.tt/2x4lRAd

A comparison of intraoperative haemostatic techniques during tonsillectomy: Suture vs electrocautery—A study to assess postoperative pain scores and duration to resumption of normal diet

Clinical Otolaryngology, EarlyView.


https://ift.tt/2IJpaOH

Comorbid inner ear disorders in 50 patients with congenital nystagmus

Clinical Otolaryngology, EarlyView.


https://ift.tt/2s1vLOc

Use of silicone gel to enhance skin wound healing by secondary intention following tumour excision on the scalp and extremities

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IFWUQV

Thyroid function in hidradenitis suppurativa: a population‐based cross‐sectional study from Denmark

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2x7rAVL

Erythrodermic pityriasis rubra pilaris managed at home: intensive community care followed by ustekinumab

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2LoHpe5

Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IGDLKt

Immunohistochemical and molecular analysis of spitzoid neoplasms with pulverocyte subclones

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IHqhT5

Chilblains accompanying interleukin‐1 receptor‐associated kinase (IRAK)‐4 deficiency

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IMhATa

Perforating folliculitis in association with liver impairment in a patient with chronic ductopenic rejection of liver transplant

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2LqVAPO

Pemphigus foliaceus and acquired haemophilia: a rare but important association with life‐threatening consequences

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IMaH4E

A painless nodule on the lower leg

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Lobs5q

Sun‐protection awareness in patients with chronic lymphocytic leukaemia

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2x7rk9f

Development of angio‐oedema after omalizumab injections in a patient with chronic spontaneous urticaria

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IIn3yE

Syphilis screening before initiation of immunosuppressive and biologic therapy for psoriasis and psoriatic arthritis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IM4k0T

Disseminated interstitial granuloma annulare associated with hepatocellular carcinoma

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IJfV5f

Intravenous immunoglobulins in dermatology. Part 1: biological mechanisms and methods of administration

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2IMaBdi

Intravenous immunoglobulins in dermatology. Part 2: clinical indications and outcomes

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2LpAUYn

Long‐term real‐life safety profile and effectiveness of fumaric acid esters in psoriasis patients: a single‐centre, retrospective, observational study

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2x7Tgdo

Comparison of PCR‐based methods for the diagnosis of cutaneous leishmaniasis in two different epidemiological scenarios: Spain and Morocco

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2IKEkr6

When passion hurts: adverse cutaneous reaction to tattoo in a FC Barcelona soccer fan (‘Culé Dermatitis’)

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2IL4OVf

Current practices for the prophylaxis against bone mineral density loss in patients with autoimmune blistering disease treated with corticosteroids: an expert survey

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2IH2kLB

Cutaneous melanoma in France in 2015 attributable to solar ultraviolet radiation and the use of sunbeds

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2IGCJ1i

Characterization of asthma in the adolescent population

Allergy, EarlyView.


https://ift.tt/2s2G8kO

Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis

Allergy, EarlyView.


https://ift.tt/2KOlqff

Atopic asthma after rhinovirus‐induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter

Allergy, EarlyView.


https://ift.tt/2sa27q7

Efficacy and absorption of topical sirolimus for the treatment of vascular anomalies in children: A case series

Pediatric Dermatology, EarlyView.


https://ift.tt/2J4sbfR

Eosinophilic annular erythema treated with dupilumab

Pediatric Dermatology, EarlyView.


https://ift.tt/2s82bFR

Self‐initiated use of topical cannabidiol oil for epidermolysis bullosa

Pediatric Dermatology, EarlyView.


https://ift.tt/2J4s8Rd

Sensitivity and specificity of ex vivo dermatoscopy: a case series

International Journal of Dermatology, EarlyView.


https://ift.tt/2x5PwJf

Hypocomplementemic urticarial vasculitis occurring in a patient with relapsing polychondritis

International Journal of Dermatology, EarlyView.


https://ift.tt/2klqtIS

Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis

International Journal of Dermatology, EarlyView.


https://ift.tt/2x69N1c

“The Evolution of Eyebrow Morphology: The Westmore Model Revisited”

International Journal of Dermatology, EarlyView.


https://ift.tt/2J3hlXe

Multiple facial translucent papules

International Journal of Dermatology, EarlyView.


https://ift.tt/2x6qZns

Dermoscopic patterns of filiform papillae of the tongue in patients with and without connective tissue autoimmune diseases

International Journal of Dermatology, EarlyView.


https://ift.tt/2IZKJ0B

Ertapenem – a potent treatment for clinical and quality of life improvement in patients with hidradenitis suppurativa

International Journal of Dermatology, EarlyView.


https://ift.tt/2s94xEi

A man with easy bruising, heart failure, and organomegaly

International Journal of Dermatology, EarlyView.


https://ift.tt/2klq7lw

Pityriasis rotunda. A clinical study in Jordan: experience of 10 years

International Journal of Dermatology, EarlyView.


https://ift.tt/2s795vb

Conservative thickness layers in Mohs micrographic surgery

International Journal of Dermatology, EarlyView.


https://ift.tt/2J4rLWP

Table of contents

The Laryngoscope, Volume 128, Issue 6, Page iii-vii, June 2018.


https://ift.tt/2IMeTB2

Masthead

The Laryngoscope, Volume 128, Issue 6, Page i-ii, June 2018.


https://ift.tt/2s2ENdM

Is depression screening in patients with acne critical?

British Journal of Dermatology, EarlyView.


https://ift.tt/2II9rz8

In the first line of her book, Dr. Feemster writes, “vaccines represent one of the greatest public health...

In the first line of her book, Dr. Feemster writes, "vaccines represent one of the greatest public health advances of the past 100 years." Still, significant disparities continue to exist in widespread availability, adherence, and acceptance of vaccines, despite profound decreases and even eradication of preventable diseases since Jenner's renowned smallpox experiments in 1796.

https://ift.tt/2ki8x1Y

The Amish have Decreased Asthma and Allergic Diseases Compared to Old Order Mennonites

The prevalence of allergic diseases is increasing worldwide, particularly in Westernized regions. Epidemiologic studies from several continents have shown an association between infants born into farming environments and significantly decreased frequency of asthma and allergic diseases. The protective factors in farming environments remain poorly understood but may include animal exposure and farm (unprocessed) milk ingestion 1,2. The Amish, Old Order Mennonites (OOM), and Hutterites are distinct Anabaptist traditional agrarian cultures.

https://ift.tt/2s2OpnU

Nonpharmacologic Considerations in the Management of Allergies and Asthma

A considerable amount of literature has been published on optimal management of patients who have allergy and/or asthma related diseases. While major progress has been reported with new and exciting pharmacological therapies which include biologically derived agents, this does not replace the need for an effective patient-provider interpersonal relationship [1]. Aside from our expertise derived from state-of-the art education (both in graduate medical education and continuing medical education) and clinical experience, there is more to optimal management of our patients' health besides the right prescription at the right time.

https://ift.tt/2J1V9wM

Provider Practices in Screening for Mental Health Concerns in Caregivers of Patients with Primary Immunodeficiency

Primary immunodeficiency disorders (PID) are a diverse group of diseases that impact the immune system and require intensive treatment. The psychosocial impact of PID may be particularly pronounced among caregivers of children diagnosed with PID who often experience disruption to work and family responsibilities related to diagnosis and treatment, and face ongoing uncertainty regarding recurrent infections, hospitalizations, and life-threatening treatment. The psychological impact of chronic diseases may influence patient medical and psychosocial outcomes as well.

https://ift.tt/2x2q5Z0

ddY Mice Fed 10% Fat Diet Exhibit High p27KIP Expression and Delayed Hepatocyte DNA Synthesis During Liver Regeneration

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2IJiJLq

Pyramidal Artery: An Artery to Pyramidal Lobe—A New Nomenclature

Abstract

Thyroid lobes are supplied by superior and inferior thyroid arteries. We dissected out a specific arterial pattern always present along with a well developed pyramidal lobe. Authors named this as "Pyramidal Artery". This may be a common unnoticed bleeding site during surgery. Thyroid anomalies are commonly observed as incidental finding during surgery. Presence of pyramidal lobe is the most common finding among other thyroid anomalies due to persistence of thyroglossal duct. Present study reported incidence of pyramidal lobe in 41.46% cases and pyramidal lobe branches off more frequently from left lobe than right. Special attention has to be paid during total thyroidectomy in order not to leave the thyroid tissue. Few such anatomical variations and surgical importance of vascular pattern in such cases is discussed in paper.

https://ift.tt/2J4t8EM

Pyramidal Artery: An Artery to Pyramidal Lobe—A New Nomenclature

Abstract

Thyroid lobes are supplied by superior and inferior thyroid arteries. We dissected out a specific arterial pattern always present along with a well developed pyramidal lobe. Authors named this as "Pyramidal Artery". This may be a common unnoticed bleeding site during surgery. Thyroid anomalies are commonly observed as incidental finding during surgery. Presence of pyramidal lobe is the most common finding among other thyroid anomalies due to persistence of thyroglossal duct. Present study reported incidence of pyramidal lobe in 41.46% cases and pyramidal lobe branches off more frequently from left lobe than right. Special attention has to be paid during total thyroidectomy in order not to leave the thyroid tissue. Few such anatomical variations and surgical importance of vascular pattern in such cases is discussed in paper.

https://ift.tt/2J4t8EM

Histone modifications and their role in epigenetics of atopy and allergic diseases

This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this develop...

https://ift.tt/2LrF1D9

Association between fractional exhaled nitric oxide, sputum induction and peripheral blood eosinophil in uncontrolled asthma

The fractional exhaled nitric oxide (FeNO) and blood eosinophils are biomarkers of eosinophilic airway inflammation used in the diagnosis and management of asthma, although induced sputum is the gold standard ...

https://ift.tt/2x9J0Bm

Ketamine and electroconvulsive therapy: so happy together?

Purpose of review Anesthetics, such as thiopental, methohexital, propofol and ketamine have been used to induce unconsciousness for electroconvulsive therapy (ECT), each with its advantages and disadvantages. Only until recently was it discovered that ketamine may have inherent antidepressant effects. We reviewed the side effect profile of ketamine and examined the literature for whether or not ketamine augments the antidepressant effects of ECT. Recent findings Systematic reviews and meta-analyses of randomized controlled trials of the potential benefits of adding ketamine to ECT treatment have generated varied conclusions. Currently there is a lack of clear evidence that ketamine with ECT is more efficacious than ECT alone. Summary Large, multicenter randomized controlled trials are needed to further investigate the potential advantages of adding ketamine to ECT for patients with severe or refractory depression. The addition of ketamine to ECT treatment may have some early beneficial effect in patients with acute depressive disorders. Most likely, ECT itself is responsible for lasting remission from severe depression. Ketamine's side effect profile may be undesirable in certain patient populations, and so the risks and benefits of the addition of this drug to ECT treatment must be weighed. Correspondence to Kathryn Cobb, MD, N2198 UNC Hospitals, CB# 7010, Chapel Hill, NC 27599-7010, USA. Tel: +1 919 966 5136; e-mail: kathryn_cobb@med.unc.edu Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2kl4nGA

Treatment of ventriculoperitoneal shunt infection and ventriculitis caused by Acinetobacter baumannii: a case report

Acinetobacter baumannii (A. baumannii) infections are a recognized problem in healthcare, causing ventriculoperitoneal shunt infection and ventriculitis. Such infections are serious intracranial infection that ca...

https://ift.tt/2x6ejNv

Linear Keratotic Lesions in a Young Woman

A woman in her 20s presented with linear hyperkeratotic papules on her right arm in a Blaschkoid pattern. What is your diagnosis?

https://ift.tt/2IGUi5c

Topical Sirolimus to Treat Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) causes the formation of hamartomatous tumors in multiple organs. Facial angiofibromas frequently arise during childhood and can be a source of patient distress owing to bleeding and effects on appearance. The standard treatment is surgical, delivered by multiple modalities, including lasers, shave excision, dermabrasion, electrosurgery, or cryosurgery. These approaches are effective but can create concerns about the potential for scarring, pain, anesthesia risk, postoperative recovery, and the need for repeated procedures delivered in the office or operating room. Consequently, there has been interest in the development of a topical therapy for home use that is painless and nonscarring. In this issue, Koenig and collaborators show that topical 0.1% or 1.0% sirolimus (rapamycin) applied once daily is safe and effective for treating facial angiofibromas. This is welcome news for many with TSC. Furthermore, these results are expected to fuel investigations into other uses for sirolimus in dermatology. The story of how topical sirolimus became a treatment option for TSC is based in scientific discoveries of its molecular target and that target's role in relevant diseases.

https://ift.tt/2s70uIU

Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa

This cross-sectional cohort analysis of electronic health records from a large US database evaluates overall and subgroup prevalence of Crohn disease among patients with hidradenitis suppurativa.

https://ift.tt/2khANS6

Mogamilizumab Prior to Allogeneic Hematopoietic Stem Cell Transplantation

This case series describes characteristics of 8 patients with mycosis fungoides or Sézary syndrome who received mogamulizumab before allogeneic hematopoietic stem cell transplantation and any resulting graft-vs-host disease–related complications.

https://ift.tt/2GIcSV3

Topical Rapamycin in Patients With Facial Angiofibromas

This randomized clinical trial examines the efficacy and safety of topical rapamycin therapy for treatment of patients with tuberous sclerosis complex–related facial angiofibromas.

https://ift.tt/2IDKCZb

Immunotherapy-Related Eruption Limited to Sites of Melanoma Metastases

This case report describes 2 patients with cutaneous eruptions secondary to immunotherapy for metastatic melanoma limited to sites of locoregional melanoma metastases.

https://ift.tt/2GINDlf

Perioperative Hyperchloremia and its Association With Postoperative Acute Kidney Injury After Craniotomy for Primary Brain Tumor Resection: A Retrospective, Observational Study

Background: Hyperchloremia is known to influence postoperative outcomes and may result in postoperative acute kidney injury (AKI). This study sought to investigate whether hyperchloremia was associated with postoperative AKI in patients who underwent surgery for primary brain tumor resection. Materials and Methods: This is a retrospective, observational study of patients who underwent craniotomy for primary brain tumor resection at a single tertiary care hospital between January 2005 and October 2017. Maximum levels of serum chloride (mmol/L) measured on postoperative days (PODs) 0 to 3 and increase in serum chloride (mmol/L), (maximum serum chloride−baseline serum chloride before surgery) were measured. We examined whether perioperative hyperchloremia was associated with postoperative AKI during PODs 0 to 3. Univariate and multivariate logistic regression analyses were used in this study. Results: A total of 726 patients were included in the analysis; of these, 39 (5.4%) were diagnosed with postoperative AKI during PODs 0 to 3. The risk of postoperative AKI was associated with maximum chloride levels (odds ratio, 1.10; 95% confidence interval, 1.02-1.19; P=0.015) and with an increase in serum chloride levels during PODs 0 to 3 (odds ratio, 1.11; 95% confidence interval, 1.04-1.19; P=0.004). Conclusions: Our study shows that perioperative hyperchloremia during PODs 0 to 3 was associated with an increased risk of postoperative AKI during this period after craniotomy for primary brain tumor resection. The authors have no funding or conflicts of interest to disclose. Address correspondence to: Sang-Hwan Do, MD, PhD, Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166, Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, South Korea (e-mail: shdo@snu.ac.kr). Received January 31, 2018 Accepted April 19, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

https://ift.tt/2s0BeEY

Ultrasound-guided single injection versus continuous sciatic nerve blockade on pain management and mobilisation after total knee arthroplasty (CoSinUS trial): A randomised, triple-blinded controlled trial

BACKGROUND Combining continuous femoral nerve blockade with single injection sciatic nerve blockade is standard peripheral nerve block practice for total knee arthroplasty (TKA) during the first 24 postoperative hours. OBJECTIVES To assess the analgesic benefits and mobilisation capability of continuous sciatic blockade in conjunction with continuous femoral nerve blockade for 72 h after arthroplasty. DESIGN Randomised, triple-blinded controlled trial. SETTING Single-Centre, German University Hospital. PATIENTS In total, 50 patients receiving continuous femoral nerve blockade (5 ml h−1 ropivacaine 0.2%) for TKA under general anaesthesia. INTERVENTIONS Patients were randomised to receive a sciatic nerve catheter with an initial dose of 10 ml ropivacaine 0.2% followed by either continuous double-blinded application of 5 ml h−1 ropivacaine 0.2% (CO) or 5 ml h−1 saline infusion (SIN). MAIN OUTCOME Measures primary endpoint: cumulative morphine consumption until 48 h postoperatively. Further endpoints included morphine consumption, pain scores, mobilisation, dynamometry until postoperative day 3. RESULTS Median [25th to 75th percentiles] cumulative morphine consumption at postoperative day 2 differed significantly between groups (CO 15 mg [11 to 25] versus SIN, 43 mg [27 to 67.5, P 

https://ift.tt/2GJPbvd

Pathogens, prejudice, and politics: the role of the global health community in the European refugee crisis

Khan, MS; Osei-Kofi, A; Omar, A; Kirkbride, H; Kessel, A; Abbara, A; Heymann, D; ... Dar, O; + view all Khan, MS; Osei-Kofi, A; Omar, A; Kirkbride, H; Kessel, A; Abbara, A; Heymann, D; Zumla, A; Dar, O; - view fewer (2016) Pathogens, prejudice, and politics: the role of the global health community in the European refugee crisis. Lancet Infectious Diseases , 16 (8) e173-e177. 10.1016/S1473-3099(16)30134-7 . Green open access

https://ift.tt/2x87VVK

Hepatitis C: global epidemiology and strategies for control

Lanini, S; Easterbrook, PJ; Zumla, A; Ippolito, G; (2016) Hepatitis C: global epidemiology and strategies for control. Clinical Microbiology and Infection , 22 (10) pp. 833-838. 10.1016/j.cmi.2016.07.035 . Green open access

https://ift.tt/2IEAJKY

Functional assessment of AIPL1 variations identified in Leber Congenital Amaurosis patients

Sacristan-Reviriego, A; Bellingham, J; Prodromou, C; van der Spuy, J; (2017) Functional assessment of AIPL1 variations identified in Leber Congenital Amaurosis patients. Presented at: 2017 ARVO Annual Meeting, Baltimore, USA. Green open access

https://ift.tt/2x7BwPj

Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study

Lanini, S; Portella, G; Vairo, F; Kobinger, GP; Pesenti, A; Langer, M; Kabia, S; ... Ippolito, G; + view all Lanini, S; Portella, G; Vairo, F; Kobinger, GP; Pesenti, A; Langer, M; Kabia, S; Brogiato, G; Amone, J; Castilletti, C; Miccio, R; Capobianchi, MR; Strada, G; Zumla, A; Di Caro, A; Ippolito, G; - view fewer (2017) Relationship Between Viremia and Specific Organ Damage in Ebola Patients: A Cohort Study. Clinical Infectious Diseases , 66 (1) pp. 36-44. 10.1093/cid/cix704 .

https://ift.tt/2IEeNzE

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma

MacGregor, TP; Carter, R; Gillies, RS; Findlay, JM; Kartsonaki, C; Castro-Giner, F; Sahgal, N; ... Sharma, RA; + view all MacGregor, TP; Carter, R; Gillies, RS; Findlay, JM; Kartsonaki, C; Castro-Giner, F; Sahgal, N; Wang, LM; Chetty, R; Maynard, ND; Cazier, JB; Buffa, F; McHugh, PJ; Tomlinson, I; Middleton, MR; Sharma, RA; - view fewer (2018) Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma. Scientific Reports , 8 , Article 7265. 10.1038/s41598-018-24232-2 . Green open access

https://ift.tt/2x60gY4

Income inequality and the labour market in Britain and the US

Blundell, R; Joyce, R; Norris Keiller, A; Ziliak, JP; (2018) Income inequality and the labour market in Britain and the US. Journal of Public Economics 10.1016/j.jpubeco.2018.04.001 . (In press). Green open access

https://ift.tt/2LniFTa

Functional assessment of AIPL1 variations identified in Leber congenital amaurosis patients.

Sacristan-Reviriego, A; Bellingham, J; Prodromou, C; van der Spuy, J; (2016) Functional assessment of AIPL1 variations identified in Leber congenital amaurosis patients. Presented at: XVII International Symposium on Retinal Degeneration, Kyoto, Japan.

https://ift.tt/2IHvKVL

Innovation in Solar Thermal Chimney Power Plants

Cottam, PJ; (2018) Innovation in Solar Thermal Chimney Power Plants. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2Lo9Bxq

Impact of the external window crack structure on indoor PM2.5 mass concentration

Chen, Z; Chen, C; Wei, S; Wu, Y; Wang, Y; Wan, Y; (2016) Impact of the external window crack structure on indoor PM2.5 mass concentration. Building and Environment , 108 (C) pp. 240-251. 10.1016/j.buildenv.2016.08.031 . Green open access

https://ift.tt/2IIz2rU

Is there sufficient evidence to repeal three decades of clinical research on chronic hepatitis C?

Ippolito, G; Zumla, A; Lanini, S; (2018) Is there sufficient evidence to repeal three decades of clinical research on chronic hepatitis C? Clinical Microbiology and Infection , 24 (4) pp. 328-331. 10.1016/j.cmi.2018.01.001 .

https://ift.tt/2Lo9jXm

Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease

Santos e Sousa, P; Bennett, CL; Chakraverty, R; (2018) Unraveling the Mechanisms of Cutaneous Graft-Versus-Host Disease. Frontiers In Immunology , 9 , Article 963. 10.3389/fimmu.2018.00963 . Green open access

https://ift.tt/2IIynXi

Design and Characterisation of a Scale-Down Platform for the Recovery of Periplasmic Fab’ From E.coli

Ahmad, Asma; (2018) Design and Characterisation of a Scale-Down Platform for the Recovery of Periplasmic Fab' From E.coli. Doctoral thesis (Eng.D), UCL (University College London).

https://ift.tt/2IDdkcF

Short-term economic impact of the Zika virus outbreak

Macciocchi, D; Lanini, S; Vairo, F; Zumla, A; Moraes Figueiredo, LT; Lauria, FN; Strada, G; ... Ippolito, G; + view all Macciocchi, D; Lanini, S; Vairo, F; Zumla, A; Moraes Figueiredo, LT; Lauria, FN; Strada, G; Brouqui, P; Puro, V; Krishna, S; Kremsner, P; Scognamiglio, P; Kohler, C; Nicastri, E; Di Caro, A; Cieri, RM; Ioannidis, JPA; Kobinger, G; Burattini, MN; Ippolito, G; - view fewer (2016) Short-term economic impact of the Zika virus outbreak. New Microbiologica , 39 (4) pp. 287-289. Green open access

https://ift.tt/2x53WJz

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE

Yadak, R; Cabrera-Pérez, R; Torres-Torronteras, J; Bugiani, M; Haeck, JC; Huston, MW; Bogaerts, E; ... de Coo, IFM; + view all Yadak, R; Cabrera-Pérez, R; Torres-Torronteras, J; Bugiani, M; Haeck, JC; Huston, MW; Bogaerts, E; Goffart, S; Jacobs, EH; Stok, M; Leonardelli, L; Biasco, L; Verdijk, RM; Bernsen, MR; Ruijter, G; Martí, R; Wagemaker, G; van Til, NP; de Coo, IFM; - view fewer (2018) Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE. Molecular Therapy: Methods & Clinical Development , 8 pp. 152-165. 10.1016/j.omtm.2018.01.001 . Green open access

https://ift.tt/2IG88oG

Cecil Helman: GP, anthropologist, writer, poet, teacher, and internationalist

Singh, S; Rosenthal, J; (2009) Cecil Helman: GP, anthropologist, writer, poet, teacher, and internationalist. British Journal of General Practice , 59 (567) , Article 790. 10.3399/bjgp09X472782 .

https://ift.tt/2x2Stu9

Mapping the mechanisms of retinal degeneration caused by mutations in the co-chaperone AIPL1

Sacristan-Reviriego, A; Bellingham, J; Michaelides, M; Bainbridge, J; Prodromou, C; van der Spuy, J; (2017) Mapping the mechanisms of retinal degeneration caused by mutations in the co-chaperone AIPL1. Presented at: EMBO Conference: Protein Quality Control: Success and Failure in Health and Disease (2017), Sant Feliu de Guixols, Spain.

https://ift.tt/2IHmGEo

Democracy in the primary classroom: an interpretative phenomenological analysis of three teachers’ experiences of sharing decision-making with pupils

Rowe, Mary Geraldine Ruth; (2018) Democracy in the primary classroom: an interpretative phenomenological analysis of three teachers' experiences of sharing decision-making with pupils. Doctoral thesis (EdD), UCL (University College London). Green open access

https://ift.tt/2IGKpAt

Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Biasco, L; Rothe, M; Büning, H; Schambach, A; (2018) Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy. Molecular Therapy: Methods & Clinical Development , 8 pp. 21-30. 10.1016/j.omtm.2017.10.002 . Green open access

https://ift.tt/2IDJfK4

What is Fichte's Thesis of the Primacy of the Practical and How does he Argue for this Thesis?

Phillips, Rory; (2017) What is Fichte's Thesis of the Primacy of the Practical and How does he Argue for this Thesis? Masters thesis (M.Phil.Stud), UCL (University College London).

https://ift.tt/2IKJb7h

USEUM: Making art accessible with crowdsourcing and gamification

Valeonti, Foteini; (2018) USEUM: Making art accessible with crowdsourcing and gamification. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2LoOCul

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation, function and EBV immunity

Publication date: Available online 22 May 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Emily S.J. Edwards, Julia Bier, Theresa S. Cole, Melanie Wong, Peter Hsu, Lucinda J. Berglund, Kaan Boztug, Anthony Lau, Emma Gostick, David A. Price, Michael O'Sullivan, Isabelle Meyts, Sharon Choo, Paul Gray, Steven M. Holland, Elissa K. Deenick, Gulbu Uzel, Stuart G. Tangye
BackgroundGermline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110δ subunit of phosphatidylinositol-3 kinase, result in hyperactivation of the PI3K-AKT-mTOR pathway and underlie a novel inborn error of immunity. Affected individuals exhibit perturbed humoral and cellular immunity, manifesting as recurrent infections, autoimmunity, hepatosplenomegaly, uncontrolled EBV and/or CMV infection, and an increased incidence of B-cell lymphoproliferation and/or lymphoma. Mechanisms underlying disease pathogenesis remain unknown.ObjectiveUnderstanding the cellular and molecular mechanisms underpinning inefficient surveillance of EBV-infected B cells is required to understand disease in individuals with PIK3CD GOF mutations, identify key molecules required for cell mediated immunity against EBV, and develop immunotherapeutic interventions for the treatment of this as well as other EBV-opathies.MethodsWe studied the consequences of PIK3CD GOF mutations on the generation, differentiation and function of CD8⁺ T cells and NK cells, which are implicated in host defense against infection with herpesviruses including EBV.ResultsPIK3CD GOF total and EBV-specific CD8⁺ T cells were skewed towards an effector phenotype, with exaggerated expression of markers associated with premature immunosenescence/exhaustion, and increased susceptibility to re-activation induced cell death. These findings were recapitulated in a novel mouse model of PI3K GOF. NK cells in PIK3CD GOF individuals also exhibited perturbed expression of differentiation-associated molecules. Both CD8⁺ T cells and NK cells had reduced capacity to kill EBV-infected B cells. PIK3CD GOF B cells had increased expression of CD48, PDL-1/2 and CD70.ConclusionsPIK3CD GOF mutations aberrantly induce exhaustion and/or senescence and impair cytotoxicity of CD8+ T and NK cells. These defects may contribute to clinical features of affected individuals, such as impaired immunity to herpesviruses and tumor surveillance.

Graphical abstract

https://ift.tt/2IH8c3l

Prognostic Significance of Lymph Node Yield and Lymph Node Ratio Prospective Observational Study

Condition:   Head and Neck Cancer
Intervention:   Diagnostic Test: Lymph Node Yield (LNY) and Lymph Node Ratio (LNR)
Sponsor:   Oreste Iocca, M.D., D.D.S.
Not yet recruiting

https://ift.tt/2ki5WF3

Spontaneous acalculous gallbladder perforation post-cardiac transplantation

Spontaneous acalculous gallbladder perforation is a rare radiological and clinical phenomenon with life-threatening consequences. In the setting of recent cardiac transplantation, the condition is increasingly uncommon and difficult to diagnose preoperatively. We describe a case of spontaneous acalculous gallbladder perforation in an intensive care unit (ICU) patient, most likely due to a combination of cardiac transplantation and immunosuppression. There are no such documented cases in the literature with an established preoperative diagnosis, to the best of our knowledge. Abdominal CT and targeted ultrasound proved complimentary in establishing the diagnosis, facilitating successful and timely treatment with urgent cholecystectomy.

https://ift.tt/2IDtAdL

Stuck guidewire due to soft tissue imposition: a rare complication of central line catheter placement

Central venous catheter (CVC) placement is a commonly done procedure but is associated with a few complications, and guidewire-related complications are one of them. In our case after induction of general anaesthesia, we planned to insert a CVC in the right internal jugular vein under ultrasound guidance. After the insertion of the introducer needle, when we tried to insert the guidewire, it got stuck and was neither moving forward nor in a backward direction. Too much force was not applied to remove the guidewire as it might have caused shearing of the guidewire and further complicated the picture. This problem was solved by simultaneous withdrawal of guidewire along with the needle, and on examination we found soft tissue debris lodged within the lumen which was preventing the guidewire movement in both directions. So, it is suggested that guidewire should be removed along with needle as a single unit if it is required.

https://ift.tt/2s4SVCs

Neuromyelitis optica spectrum disorder presenting as rhomboencephalitis

Rhomboencephalitis, at least in its acute phase, is often a severely disabling syndrome, and can be life threatening. A range of underlying conditions can lead to this clinical syndrome. Rapid diagnosis to initiate treatment early is key to a beneficial outcome. We report the case of a 22 year old Afro-Caribbean woman, who presented with a two -week history of walking difficulties, upper limb incoordination and slurred speech. Her brainstem function deteriorated at pace, and she developed hypersomnia. A broad diagnostic approach led to prophylactic treatment for the most common infectious causes. This did not improve her symptoms. Non-infectious inflammatory causes were therefore considered and plasma exchange treatment was initiated leading to marked improvement within days. Screening for autoimmune conditions confirmed aquaporin-4 positive neuromyelitis optica spectrum disorder (NMOSD) as the underlying cause. Immunotherapy with rituximab was started. So far, no relapse has been observed. While the definition of NMOSD continues to be refined, aquaporin-4 testing should be considered early in patients presenting with rhomboencephalitis who do not respond to antibiotic and antiviral treatment. Vigilance and early intervention are key to limit morbidity and mortality from NMOSD.

https://ift.tt/2IFQJfN

Cerebral Microbleeds: Imaging and Clinical Significance

Haller, S; Vernooij, MW; Kuijer, JPA; Larsson, E-M; Jager, HR; Barkhof, F; (2018) Cerebral Microbleeds: Imaging and Clinical Significance. Radiology , 287 (1) pp. 11-28. 10.1148/radiol.2018170803 .

https://ift.tt/2J4ySPa

Education, Work and Crime: Evidence from Educational Reforms

Vieira Marques Da Costa, RM; (2018) Education, Work and Crime: Evidence from Educational Reforms. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2s5y8hX

Measurable Residual Disease at Induction Redefines Partial Response in Acute Myeloid Leukemia and Stratifies Outcomes in Patients at Standard Risk Without NPM1 Mutations

Freeman, SD; Hills, RK; Virgo, P; Khan, N; Couzens, S; Dillon, R; Gilkes, A; ... Russell, NH; + view all Freeman, SD; Hills, RK; Virgo, P; Khan, N; Couzens, S; Dillon, R; Gilkes, A; Upton, L; Nielsen, OJ; Cavenagh, JD; Jones, G; Khwaja, A; Cahalin, P; Thomas, I; Grimwade, D; Burnett, AK; Russell, NH; - view fewer (2018) Measurable Residual Disease at Induction Redefines Partial Response in Acute Myeloid Leukemia and Stratifies Outcomes in Patients at Standard Risk Without NPM1 Mutations. Journal of Clinical Oncology , 36 (15) pp. 1486-1497. 10.1200/JCO.2017.76.3425 .

https://ift.tt/2kk1YMk

Going Beyond Relevance: Role of effort in Information Retrieval

Verma, Manisha; (2017) Going Beyond Relevance: Role of effort in Information Retrieval. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2s6Bn8N

TOWARDS A THEORY OF URBAN DESIGN UNDER NEOLIBERALISM. The Urban Revolution as methodology

Vergara Perucich, JF; (2018) TOWARDS A THEORY OF URBAN DESIGN UNDER NEOLIBERALISM. The Urban Revolution as methodology. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2J4yEaM

#MeToo and the promise and pitfalls of challenging rape culture through digital feminist activism

Mendes, K; Ringrose, JL; Keller, J; (2018) #MeToo and the promise and pitfalls of challenging rape culture through digital feminist activism. European Journal of Women's Studies , 25 (2) pp. 236-246. 10.1177/1350506818765318 . Green open access

https://ift.tt/2x0CzAm

Expression and localization of NUB1 in Tauopathy and Alzheimer’s disease models

Guarascio, R; Edwards, F; Salih, D; van der Spuy, J; (2017) Expression and localization of NUB1 in Tauopathy and Alzheimer's disease models. In: UCL 2015 Neuroscience Symposium Poster Abstract Booklet. UCL Green open access

https://ift.tt/2J4y7FO

The role of NUB1 in the clearance of tau aggregates in Alzheimer's disease

Guarascio, R; van der Spuy, J; (2017) The role of NUB1 in the clearance of tau aggregates in Alzheimer's disease. Presented at: Alzheimer's Association International Conference (AAIC) 2017, London, UK.

https://ift.tt/2s5xPUl

The effect of an optical network on-chip on the performance of chip multiprocessors

Van Laer, Anouk; (2018) The effect of an optical network on-chip on the performance of chip multiprocessors. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2J4y0Ko

Impact of occupant behaviour on the energy-saving potential of retrofit measures for a public building in the UK

Wei, S; Hassan, TM; Firth, SK; Fouchal, F; (2017) Impact of occupant behaviour on the energy-saving potential of retrofit measures for a public building in the UK. Intelligent Buildings International , 9 (2) pp. 97-106. 10.1080/17508975.2016.1139538 . Green open access

https://ift.tt/2x4Y6Ij

Integration of environmental aspects in modelling and optimisation of water supply chains

Koleva, MN; Calderón, AJ; Zhang, D; Styan, CA; Papageorgiou, LG; (2018) Integration of environmental aspects in modelling and optimisation of water supply chains. Science of The Total Environment , 636 pp. 314-338. 10.1016/j.scitotenv.2018.03.358 .

https://ift.tt/2J4xUT2

Social Media Use in the Australian Energy and Resources Sectors

Styan, C; (2018) Social Media Use in the Australian Energy and Resources Sectors. In: Proceedings of the APPEA 2018 Conference and Exhibition. Australian Petroleum Production and Exploration Association: Adelaide, Australia. (In press).

https://ift.tt/2s7qRy6

Of Kids & Parents. By Emil Hakl. Translated by Marek Tomin. Pp. 153. Prague: Twisted Spoon Press. 2008. £13.00. ISBN: 978-8-086-26430-1

Zusi, PA; (2009) Of Kids & Parents. By Emil Hakl. Translated by Marek Tomin. Pp. 153. Prague: Twisted Spoon Press. 2008. £13.00. ISBN: 978-8-086-26430-1. [Review]. Central Europe , 7 (2) pp. 185-186. 10.1179/147909609X12490449629285 . Green open access

https://ift.tt/2kjxI4k

Motor Cortex Stimulation for Deafferentation Pain

Abstract

Purpose of Review

Since the early 1990s, motor cortex stimulation (MCS) has been a unique treatment modality for patients with drug-resistant deafferentation pain. While underpowered studies and case reports have limited definitive, data-driven analysis of MCS in the past, recent research has brought new clarity to the MCS literature and has helped identify appropriate indications for MCS and its long-term efficacy.

Recent Findings

In this review, new research in MCS, repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) are analyzed and compared with historical landmark papers. Currently, MCS is effective in providing relief to 40–64% of patients, with decreasing analgesic effect over time addressed by altering stimulation settings. rTMS and tDCS, two historic, non-invasive stimulation techniques, are providing new alternatives for the treatment of deafferentation pain, with rTMS finding utility in identifying MCS responders. Future advances in electrode arrays, neuro-navigation, and high-definition tDCS hold promise in providing pain relief to growing numbers of patients.

Summary

Deafferentation pain is severe, disabling, and remains a challenge for patients and providers alike. Over the last several years, the MCS literature has been revitalized with studies and meta-analyses demonstrating MCS effectiveness and providing guidance in identifying responders. At the same time, rTMS and tDCS, two time-honored non-invasive stimulation techniques, are finding new utility in managing deafferentation pain and identifying good MCS candidates. As the number of potential therapies grow, the clinician's role is shifting to personalizing treatment to the unique pain of each patient. With new treatment modalities, this form of personalized medicine is more possible than ever before.

https://ift.tt/2IZ8qq1

Introduction of a laser safety checklist in the ENT operating theatre—our experience across twenty cases

Clinical Otolaryngology, EarlyView.


https://ift.tt/2s3ERcr

Undergraduate ear, nose and throat training: How do we inspire the next generation?

Clinical Otolaryngology, EarlyView.


https://ift.tt/2J6mfmm

Multiparametric Whole Blood Dissection: A one-shot comprehensive picture of the human hematopoietic system

Basso-Ricci, L; Scala, S; Milani, R; Migliavacca, M; Rovelli, A; Bernardo, ME; Ciceri, F; ... Biasco, L; + view all Basso-Ricci, L; Scala, S; Milani, R; Migliavacca, M; Rovelli, A; Bernardo, ME; Ciceri, F; Aiuti, A; Biasco, L; - view fewer (2017) Multiparametric Whole Blood Dissection: A one-shot comprehensive picture of the human hematopoietic system. Cytometry Part A , 91 (10) pp. 952-965. 10.1002/cyto.a.23148 . Green open access

https://ift.tt/2KM2opP

Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer's Disease Patients

Ketter, N; Brashear, HR; Bogert, J; Di, J; Miaux, Y; Gass, A; Purcell, DD; ... Arrighi, HM; + view all Ketter, N; Brashear, HR; Bogert, J; Di, J; Miaux, Y; Gass, A; Purcell, DD; Barkhof, F; Arrighi, HM; - view fewer (2017) Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer's Disease Patients. Journal of Alzheimer's Disease , 57 (2) pp. 557-573. 10.3233/JAD-160216 . Green open access

https://ift.tt/2LkWmh4

Warning systems as social processes for Bangladesh cyclones

Kelman, I; Ahmed, B; Esraz-Ul-Zannat, M; Saroar, MM; Fordham, M; Shamsudduha, M; (2018) Warning systems as social processes for Bangladesh cyclones. Disaster Prevention & Management (In press).

https://ift.tt/2GHtBHK

Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types

Zhang, Y; Jonkman, L; Klauser, A; Barkhof, F; Yong, VW; Metz, LM; Geurts, JJG; (2016) Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types. Multiple Sclerosis Journal , 22 (12) pp. 1569-1577. 10.1177/1352458515624771 . Green open access

https://ift.tt/2LlV1qo

Guest editorial - Development and climate change in Small Island Developing States

Moncada, S; Briguglio, LP; Bambrick, H; Kelman, I; (2018) Guest editorial - Development and climate change in Small Island Developing States. International Journal of Climate Change Strategies and Management 10.1108/IJCCSM-03-2018-184 . (In press).

https://ift.tt/2KJ2Q8r

A Longitudinal Study on Resting State Functional Connectivity in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease

Hafkemeijer, A; Moller, C; Dopper, EGP; Jiskoot, LC; van den Berg-Huysmans, AA; van Swieten, JC; van der Flier, WM; ... Rombouts, SARB; + view all Hafkemeijer, A; Moller, C; Dopper, EGP; Jiskoot, LC; van den Berg-Huysmans, AA; van Swieten, JC; van der Flier, WM; Vrenken, H; Pijnenburg, YAL; Barkhof, F; Scheltens, P; van der Grond, J; Rombouts, SARB; - view fewer (2017) A Longitudinal Study on Resting State Functional Connectivity in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. Journal of Alzheimer's Disease , 55 (2) pp. 521-537. 10.3233/JAD-150695 . Green open access

https://ift.tt/2LlIiE0

Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

Tillema, JM; Hust, HE; Rocca, MA; Vrenken, H; Steenwijk, MD; Damjanovic, D; Enzinger, C; ... Barkhof, F; + view all Tillema, JM; Hust, HE; Rocca, MA; Vrenken, H; Steenwijk, MD; Damjanovic, D; Enzinger, C; Ropele, S; Tedeschi, G; Gallo, A; Ciccarelli, O; Rovira, A; Montalban, X; de Stefano, N; Stromillo, ML; Filippi, M; Barkhof, F; - view fewer (2016) Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study. Multiple Sclerosis Journal , 22 (7) pp. 901-909. 10.1177/1352458515607650 . Green open access

https://ift.tt/2KIE7AU

Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis

Moller, C; Pijnenburg, YAL; van der Flier, WM; Versteeg, A; Tijms, B; de Munck, JC; Hafkemeijer, A; ... Wink, AM; + view all Moller, C; Pijnenburg, YAL; van der Flier, WM; Versteeg, A; Tijms, B; de Munck, JC; Hafkemeijer, A; Rombouts, SARB; van der Grond, J; van Swieten, J; Dopper, E; Scheltens, P; Barkhof, F; Vrenken, H; Wink, AM; - view fewer (2016) Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis. Radiology , 279 (3) pp. 838-848. 10.1148/radiol.2015150220 . Green open access

https://ift.tt/2LoEFgr

Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission

Hui, DS; Azhar, EI; Kim, YJ; Memish, ZA; Oh, MD; Zumla, A; (2018) Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission. The Lancet Infectious Diseases 10.1016/S1473-3099(18)30127-0 . (In press).

https://ift.tt/2GGeP4j

Sociodemographic variation in a novel behavioural risk factor index for cancer

Quaife, S; Waller, J; Stevens, C; Vrinten, C; Smith, S; Shahab, L; von Wagner, C; (2018) Sociodemographic variation in a novel behavioural risk factor index for cancer. In: SBM 39th Annual Meeting Abstract Supplement. (pp. S704-S704). OXFORD UNIV PRESS INC

https://ift.tt/2IWIPxZ

Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease

Cover, KS; Vanschijndel, RA; Versteeg, A; Leung, KK; Mulder, ER; Jong, RA; Visser, PJ; ... Alzheimer's Disease Neuroimaging Initiative (neuGRID), .; + view all Cover, KS; Vanschijndel, RA; Versteeg, A; Leung, KK; Mulder, ER; Jong, RA; Visser, PJ; Redolfi, A; Revillard, J; Grenier, B; Manset, D; Damangir, S; Bosco, P; Vrenken, H; van Dijk, BW; Frisoni, GB; Barkhof, F; Alzheimer's Disease Neuroimaging Initiative (neuGRID), .; - view fewer (2016) Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease. Psychiatry Research: Neuroimaging , 252 pp. 26-35. 10.1016/j.pscychresns.2016.04.006 . Green open access

https://ift.tt/2GGezlR

Microcosm and the Virgilian persona

Mac Góráin, F; (2009) Microcosm and the Virgilian persona. Camenae , 7

https://ift.tt/2IZTyHT

Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators

Sumner, RP; Ren, H; Ferguson, BJ; Smith, GL; (2016) Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators. Vaccine , 34 (40) pp. 4827-4834. 10.1016/j.vaccine.2016.08.002 . Green open access

https://ift.tt/2Lk6yGu

Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

Vijverberg, EGB; Dols, A; Krudop, WA; Peters, A; Kerssens, CJ; van Berckel, BNM; Wattjes, MP; ... Pijnenburg, YAL; + view all Vijverberg, EGB; Dols, A; Krudop, WA; Peters, A; Kerssens, CJ; van Berckel, BNM; Wattjes, MP; Barkhof, F; Gossink, F; Prins, ND; Stek, ML; Scheltens, P; Pijnenburg, YAL; - view fewer (2016) Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome. Dementia and Geriatric Cognitive Disorders , 41 (3-4) pp. 210-219. 10.1159/000444849 . Green open access

https://ift.tt/2GJV1ga

Parity of access to memory services in London for the BAME population: a cross-sectional study.

Cook, L; Mukherjee, S; McLachlan, T; Shah, R; Livingston, G; Mukadam, N; (2018) Parity of access to memory services in London for the BAME population: a cross-sectional study. Aging Ment Health 10.1080/13607863.2018.1442413 . (In press).

https://ift.tt/2IYMMlL

The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era

Floyd, K; Glaziou, P; Zumla, A; Raviglione, M; (2018) The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era. Lancet Respiratory Medicine , 6 (4) pp. 299-314. 10.1016/S2213-2600(18)30057-2 .

https://ift.tt/2GFVRul

Kucher, Primus-Heinz, Hrsg., Literatur und Kultur im Österreich der Zwanziger Jahre

Zusi, PA; (2009) Kucher, Primus-Heinz, Hrsg., Literatur und Kultur im Österreich der Zwanziger Jahre. Monatshefte: fuer deutschsprachige literatur und kultur , 101 (2) pp. 285-287.

https://ift.tt/2KNOYK2

White Matter Diffusion Changes during the First Year of Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis

Wiebenga, OT; Schoonheim, MM; Hulst, HE; Nagtegaal, GJA; Strijbis, EMM; Steenwijk, MD; Polman, CH; ... Geurts, JJG; + view all Wiebenga, OT; Schoonheim, MM; Hulst, HE; Nagtegaal, GJA; Strijbis, EMM; Steenwijk, MD; Polman, CH; Pouwels, PJW; Barkhof, F; Geurts, JJG; - view fewer (2016) White Matter Diffusion Changes during the First Year of Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis. American Journal Of Neuroradiology , 37 (6) pp. 1030-1037. 10.3174/ajnr.A4690 . Green open access

https://ift.tt/2IYZl0u

Hlukhovych, Adrianna, “. . . wie ein dunkler sprung durch eine helle tasse . . .” Rainer Maria Rilkes Poetik des Blinden. Eine ukrainische Spur

Zusi, PA; (2009) Hlukhovych, Adrianna, ". . . wie ein dunkler sprung durch eine helle tasse . . ." Rainer Maria Rilkes Poetik des Blinden. Eine ukrainische Spur. Monatshefte: fuer deutschsprachige literatur und kultur , 101 (3) pp. 437-438.

https://ift.tt/2GHffY8

B cells or T cells in TB: a continuing conundrum

Maeurer, M; Rao, M; Zumla, A; (2018) B cells or T cells in TB: a continuing conundrum. Lancet Respiratory Medicine , 6 (4) pp. 237-238. 10.1016/S2213-2600(18)30080-8 .

https://ift.tt/2J3d5Hi