A florid paranasal sinus reaction from a systemic disease

Publication date: Available online 19 April 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): G. Barrett, N. Keates, E. Kyrodimou, H. Wilson




https://ift.tt/2HvVI1c

Editorial Board

Publication date: June 2018
Source:Clinical Immunology, Volume 191





https://ift.tt/2JVh6LA

Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity

Publication date: Available online 18 April 2018
Source:Clinical Immunology
Author(s): Merve Iris, Pei-Suen Tsou, Amr H. Sawalha
Caffeine is a widely consumed pharmacologically active product. We focused on characterizing immunomodulatory effects of caffeine on peripheral blood mononuclear cells. Caffeine at high doses showed a robust downregulatory effect on cytokine activity and genes related to several autoimmune diseases including lupus and rheumatoid arthritis. Dose-dependent validation experiments showed downregulation at the mRNA levels of key inflammatory genes including STAT1, TNF, and PPARG. TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee. Cytokine levels of IL-8, MIP-1β, IL-6, IFN-γ, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment. Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment. Further studies exploring disease-modulating potential of caffeine in autoimmune diseases and further exploring the mechanisms involved are warranted.



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Laryngo-Rhino-Otologie 2018; S 02 Article in Thieme eJournals: Table of contents | Congress

Laryngo-Rhino-Otologie 2018; S 02

Article in Thieme eJournals:
Table of contents  |  Congress

https://ift.tt/2HJJH5X

A Case of Septicemia due to Nonocclusive Mesenteric Ischemia Occurring in Induction Chemotherapy

In nonocclusive mesenteric ischemia (NOMI), mesenteric ischemia and intestinal necrosis occur despite the absence of organic blockage in mesenteric blood vessels. As abdominal pain is often absent and few characteristic findings are seen in blood biochemistry, imaging diagnosis or other examinations, discovery is often delayed. With a mortality rate of 56–79%, NOMI is a very serious disease. However, few reports have described this pathology in association with chemotherapy regimens such as those used for malignant head and neck tumors. We encountered a case of NOMI during induction therapy combining cisplatin, docetaxel, and 5-fluorouracil. The patient was a 74-year-old man receiving chemotherapy for T2N2bM0 stage IVA oropharyngeal carcinoma. Febrile neutropenia appeared on treatment day 8. An antibacterial agent and a granulocyte colony-stimulating factor were administered, but septic shock developed and he was transferred to the intensive care unit. Abdominal distension was present and contrast-enhanced computed tomography of the abdomen suggested NOMI. Emergency surgery on day 9 resected the necrotized small intestine and created a single-hole ileostomy. The patient subsequently recovered with 2 weeks of continuous hemodiafiltration and other intensive therapies. Otolaryngological surgeons seldom encounter intestinal diseases, which are thus easily overlooked. The present case report may help in achieving early diagnosis.

https://ift.tt/2HKPYyb

Electroconvulsive therapy for depression in a patient with an inspire hypoglossal nerve stimulator device for obstructive sleep apnea: A case report

Obstructive sleep apnea (OSA) is a common disorder that affects 5–10% of the US adult population [1]. Affected patients report significant reduction in quality of life due to poor sleep quality, excessive daytime fatigue, and disruption of partner's sleep quality due to chronic snoring. In addition, moderate to severe OSA is highly associated with hypertension, insulin resistance, dyslipidemia, vascular disease, and cardiac dysrhythmias [1], and is an independent risk factor for all-cause mortality [2].

https://ift.tt/2qJ3avD

The fork in the road: A laryngeal filter airway foreign body

Upper aero-digestive tract foreign body management can be complicated and life threatening in both adult and pediatric populations. The variation seen with foreign bodies including shape, material, and duration of ingestion can impact clinical decision making and management. The objective of this report is to demonstrate a complicated case of upper airway obstruction by a plastic fork.

https://ift.tt/2Hbp7yt

Meat reintroduction in a patient with alpha-gal allergy

A 56-year-old woman presented to a drug allergy clinic for evaluation of a possible allergic reaction to acetaminophen. Two months before presentation the patient took 1000mg acetaminophen for pain relief and five hours later awoke with pruritic hives that resolved with diphenhydramine. Two weeks later, she took acetaminophen and developed pruritic hives four hours later, this time with vomiting, cramping, pruritic mouth, and sensation of throat closure. These symptoms resolved with diphenhydramine.

https://ift.tt/2Haq7Tn

Leaving the nest: improving food allergy management on college campuses

The transition from adolescence to young adulthood marks a developmental period where responsibility for management of chronic conditions such as food allergy shifts from the caregiver to the young adult. Fatal food-induced anaphylaxis is most common among adolescents and young adults. However, colleges are currently not well-positioned to provide integrated support for students with food allergies.

https://ift.tt/2HvZtnn

Rhinitis and Sinusitis in the Geriatric Population

Rhinitis and sinusitis are common medical conditions that affect the geriatric population and have a significant impact on their quality of life. Because few studies examine differences in the clinical management between the geriatric and general adult population, therapies should be based on current guidelines. Special considerations should be made when treating these patients in regards to multiple comorbidities and the potential for drug interactions from polypharmacy. Further research on the pathogenesis of sinusitis in the geriatric population may provide specific differences in the clinical management in this population.

https://ift.tt/2Hax9rp

Pneumolabyrinth, intracochlear and vestibular fluid loss after cochlear implantation

The present case was a 38-year-old male who presented with progressive hearing loss, resulting in profound bilateral hearing loss. He had a past history of childhood medulloblastoma, which was treated with posterior fossa craniotomy and radiotherapy. A ventriculoperitoneal (VP) shunt was put in place to manage the hydrocephalus. Cochlear implantation (CI) was carried out on his right ear by a standard procedure. At CI activation, the electric impedance of the electrode was very high, and computed tomography revealed that there was no area of liquid density, suggesting depletion of the perilymph in the cochlea and vestibule.

https://ift.tt/2EZufj8

Low frequency of soya allergy in peanut‐allergic children: Relevance to allergen labelling on medicines

Allergy, EarlyView.


https://ift.tt/2JXysra

Osteopenia and Multiple Fractures in an Infant With Harlequin Ichthyosis

This case report describes the occurrence of osteopenia and multiple fractures in an infant with harlequin ichthyosis.

https://ift.tt/2vxV0Mj

Error in Data

In the recent article by Ashchyan et al, there were errors in the Abstract, Results, and Discussion. The correct number (percentage) of patients with comorbidities is 238 (66.9%). The article has been corrected online.

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Association of Marital Status With T Stage and Management of Early-Stage Melanoma

This population-based study evaluates the association between marital status and T stage at the time of presentation and the decision for sentinel lymph node biopsy in patients with early-stage melanoma included in the Surveillance, Epidemiology, and End Results database.

https://ift.tt/2EXvtLC

Warty Fingers and Toes in a Child With Congenital Lymphedema

This case report describes the occurrence of warty fingers and toes in a child with congenital lymphedema.

https://ift.tt/2HKPxnN

Accuracy of Skin Cancer Diagnosis by Physician Assistants Compared With Dermatologists

This medical record review evaluates biopsy reports from skin cancer screening examinations to compare dermatologist vs physician assistant accuracy in diagnosing skin cancer in a large health care system.

https://ift.tt/2EYbYCH

Skin Examination Patterns and Thinner Nodular vs Superficial Spreading Melanoma at Diagnosis

This cross-sectional pooled analysis analyzes the association between skin examination practices and diagnosis with thin nodular or superficial spreading melanoma.

https://ift.tt/2HKPoRh

Erythematous Plaque on the Inferior Eyelid

A 40-year-old woman presented with an 8-year history of a growing erythematous plaque on the left lower eyelid; physical examination revealed a single plaque involving the left lower eyelid, including its border, and eyelashes were absent. What is your diagnosis?

https://ift.tt/2EXESCQ

Association of Celecoxib Use With Decreased Opioid Requirements After Head and Neck Cancer Surgery

This matched cohort study examines the association of the addition of celecoxib to the standard analgesia regimen with opioid use in patients after head and neck cancer surgery.

https://ift.tt/2H95Jly

Human papillomavirus: An unlikely etiologic factor in sinonasal inverted papilloma

The Laryngoscope, EarlyView.


https://ift.tt/2qLTmky

Photodynamic therapy induces antifibrotic alterations in primary human vocal fold fibroblasts

The Laryngoscope, EarlyView.


https://ift.tt/2Hayq1D

Long‐term outcome of selective neurectomy for refractory periocular synkinesis

The Laryngoscope, EarlyView.


https://ift.tt/2qGBQ0U

Treatment of chronic neurogenic cough with in‐office superior laryngeal nerve block

The Laryngoscope, EarlyView.


https://ift.tt/2Hay9M9

Sonographic assessment of swallowing in irradiated nasopharyngeal carcinoma patients

The Laryngoscope, EarlyView.


https://ift.tt/2qJ6l6t

The Probabilities of Trees and Cladograms under Ford’s -Model

Ford's -model is one of the most popular random parametric models of bifurcating phylogenetic tree growth, having as specific instances both the uniform and the Yule models. Its general properties have been used to study the behavior of phylogenetic tree shape indices under the probability distribution it defines. But the explicit formulas provided by Ford for the probabilities of unlabeled trees and phylogenetic trees fail in some cases. In this paper we give correct explicit formulas for these probabilities.

https://ift.tt/2vpkhbo

The DNA of Bacteria of the World Ocean and the Earth in Cosmic Dust at the International Space Station

Cosmic dust samples from the surface of the illuminator of the International Space Station (ISS) were collected by a crew member during his spacewalk. The sampler with tampon in a vacuum container was delivered to the Earth. Washouts from the tampon's material and the tampon itself were analyzed for the presence of bacterial DNA by the method of nested PCR with primers specific to DNA of the genus Mycobacteria, DNA of the strains of capsular bacteria Bacillus, and DNA encoding 16S ribosomal RNA. The results of amplification followed by sequencing and phylogenetic analysis indicated the presence of the bacteria of the genus Mycobacteria and the extreme bacterium of the genus Delftia in the samples of cosmic dust. It was shown that the DNA sequence of one of the bacteria of the genus Mycobacteria was genetically similar to that previously observed in superficial micro layer at the Barents and Kara seas' coastal zones. The presence of the wild land and marine bacteria DNA on the ISS suggests their possible transfer from the stratosphere into the ionosphere with the ascending branch of the global electric circuit. Alternatively, the wild land and marine bacteria as well as the ISS bacteria may all have an ultimate space origin.

https://ift.tt/2JV67BL

Molekulargenetische Diagnostik – zielgerichtete Therapie des malignen Melanoms

Zusammenfassung

Hintergrund

Mit der Identifizierung der Schlüsselrolle des MAPK-Signalwegs (MAPK „mitogen-activated protein kinase") für die Entstehung und Progression des malignen Melanoms gelang ein Durchbruch in dessen Behandlung. Die Entwicklung zielgerichteter Therapien und Immuntherapien führte zu einem breiten therapeutischen Spektrum in der Behandlung fortgeschrittener oder metastasierter Melanome.

Ziel

Dieser Artikel befasst sich mit der Wirksamkeit der aktuellen selektiven Kinaseinhibitoren bei der Behandlung des malignen Melanoms mit nachgewiesener BRAF-Mutation und auch den seltener vorkommenden Mutationen im NRAS- und cKIT-Gen. Die Ergebnisse neuester klinischer Studien einschließlich des Toxizitätsprofils sowie neue Therapieansätze werden beschrieben.

Material und Methoden

Diese Arbeit basiert auf einer selektiven Literaturrecherche in der Datenbank PubMed und ClinicalTrials zum Thema Behandlung des fortgeschrittenen Melanoms.

Ergebnisse

Eine Kombination von BRAF- und MEK-Inhibitoren führt zu einer Steigerung des Therapieansprechens und des Gesamtüberlebens im Vergleich zur Chemotherapie oder Monotherapie. Weitere spezifische Inhibitoren zeigen vielversprechende Resultate.

Diskussion

Durch die zielgerichtete Therapie und Checkpointblockade hat sich die Prognose des fortgeschrittenen und metastasierten Melanoms deutlich verbessert. Eine Kombination dieser therapeutischen Ansätze, könnte zukünftig in der Behandlung des Melanoms eine wichtige Rolle spielen. Sowohl eine detaillierte genetische Analyse des Tumors als auch ein besseres Verständnis der biologischen Prozesse sind notwendig, um insbesondere hinsichtlich der Resistenzmechanismen die Wirksamkeit moderner Melanomtherapien zu verbessern.

https://ift.tt/2J5tck1

A novel method for demonstrating cold agglutinin disease: a case report

Cold agglutinin disease is a rare disorder characterized by an autoimmune hemolytic anemia occurring at low temperatures. Physical examination findings, often limited to acrocyanosis, are combined with a therm...

https://ift.tt/2HHIcVM

Kaposi Sarcoma of the Ear in HIV-Negative Patients

https://ift.tt/2HuoMWS

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

Brownjohn, PW; Smith, J; Solanki, R; Lohmann, E; Houlden, H; Hardy, J; Dietmann, S; Brownjohn, PW; Smith, J; Solanki, R; Lohmann, E; Houlden, H; Hardy, J; Dietmann, S; Livesey, FJ; - view fewer (2018) Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem Cell Reports , 10 (4) pp. 1294-1307. 10.1016/j.stemcr.2018.03.003 . Green open access

https://ift.tt/2HKhtIr

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

Wall, RJ; Ferguson, DJP; Freville, A; Franke-Fayard, B; Brady, D; Zeeshan, M; Bottrill, AR; ... Tewari, R; + view all Wall, RJ; Ferguson, DJP; Freville, A; Franke-Fayard, B; Brady, D; Zeeshan, M; Bottrill, AR; Wheatley, S; Fry, AM; Janse, CJ; Yamano, H; Holder, AA; Guttery, DS; Tewari, R; - view fewer (2018) Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Scientific Reports , 8 , Article 5610. 10.1038/s41598-018-23871-9 . Green open access

https://ift.tt/2EYh7L8

Environmental benefits of bike sharing: A big data-based analysis

Zhang, Y; Mi, Z; (2018) Environmental benefits of bike sharing: A big data-based analysis. Applied Energy , 220 pp. 296-301. 10.1016/j.apenergy.2018.03.101 . (In press).

https://ift.tt/2HKKfsf

Machine Learning Based Localization and Classification with Atomic Magnetometers

Deans, C; Griffin, LD; Marmugi, L; Renzoni, F; (2018) Machine Learning Based Localization and Classification with Atomic Magnetometers. Physical Review Letters , 120 (3) , Article 033204. 10.1103/PhysRevLett.120.033204 . Green open access

https://ift.tt/2HHnYvq

A synthesis of the evidence on peer research with potentially vulnerable adults: how this relates to dementia

Di Lorito, C; Birt, L; Poland, F; Csipke, E; Gove, D; Diaz-Ponce, A; Orrell, M; (2017) A synthesis of the evidence on peer research with potentially vulnerable adults: how this relates to dementia. International Journal of Geriatric Psychiatry , 32 (1) pp. 58-67. 10.1002/gps.4577 . Green open access

https://ift.tt/2EUuEDj

Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis

Thust, SC; Hassanein, S; Bisdas, S; Rees, JH; Hyare, H; Maynard, JA; Brandner, S; ... Mancini, L; + view all Thust, SC; Hassanein, S; Bisdas, S; Rees, JH; Hyare, H; Maynard, JA; Brandner, S; Tur, C; Jäger, HR; Yousry, TA; Mancini, L; - view fewer (2018) Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis. European Radiology 10.1007/s00330-018-5351-0 . (In press). Green open access

https://ift.tt/2HIfV1w

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin

McWilliam, SJ; Antoine, DJ; Jorgensen, AL; Smyth, RL; Pirmohamed, M; (2018) Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin. Scientific Reports , 8 , Article 5094. 10.1038/s41598-018-23466-4 . Green open access

https://ift.tt/2EXtBT8

Relationship between Tibial conformation, cage size and advancement achieved in TTA procedure

Meeson, RL; Corah, L; Conroy, MC; Calvo, I; (2018) Relationship between Tibial conformation, cage size and advancement achieved in TTA procedure. BMC Veterinary Research , 14 , Article 104. 10.1186/s12917-018-1433-0 . Green open access

https://ift.tt/2HJ4dU5

Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts

Dubey, M; Brouwers, E; Hamilton, EMC; Stiedl, O; Bugiani, M; Koch, H; Kole, MHP; ... Min, R; + view all Dubey, M; Brouwers, E; Hamilton, EMC; Stiedl, O; Bugiani, M; Koch, H; Kole, MHP; Boschert, U; Wykes, RC; Mansvelder, HD; van der Knaap, MS; Min, R; - view fewer (2018) Seizures and disturbed brain potassium dynamics in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts. Annals of Neurology , 83 (3) pp. 636-649. 10.1002/ana.25190 . Green open access

https://ift.tt/2vmglIl

Dispersive magnetic and electronic excitations in iridate perovskites probed by oxygen K-edge resonant inelastic x-ray scattering

Lu, X; Olalde-Velasco, P; Huang, Y; Bisogni, V; Pelliciari, J; Fatale, S; Dantz, M; ... Schmitt, T; + view all Lu, X; Olalde-Velasco, P; Huang, Y; Bisogni, V; Pelliciari, J; Fatale, S; Dantz, M; Vale, JG; Hunter, EC; Chang, J; Strocov, VN; Perry, RS; Grioni, M; McMorrow, DF; Ronnow, HM; Schmitt, T; - view fewer (2018) Dispersive magnetic and electronic excitations in iridate perovskites probed by oxygen K-edge resonant inelastic x-ray scattering. [Rapid communication]. Physical Review B: Condensed Matter and Materials Physics , 97 (4) , Article 041102(R). 10.1103/PhysRevB.97.041102 . Green open access

https://ift.tt/2HKK8wP

Quality improvement initiatives for hospitalised small and sick newborns in low- and middle-income countries: a systematic review

Zaka, N; Alexander, EC; Manikam, L; Norman, ICF; Akhbari, M; Moxon, S; Ram, PK; ... Pearson, L; + view all Zaka, N; Alexander, EC; Manikam, L; Norman, ICF; Akhbari, M; Moxon, S; Ram, PK; Murphy, G; English, M; Niermeyer, S; Pearson, L; - view fewer (2018) Quality improvement initiatives for hospitalised small and sick newborns in low- and middle-income countries: a systematic review. Implementation Science , 13 , Article 20. 10.1186/s13012-018-0712-2 . Green open access

https://ift.tt/2EXts22

Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study

Bienertova-Vasku, J; Grulichova, M; Mikes, O; Zlamal, F; Prusa, T; Pohorala, A; Andryskova, L; Bienertova-Vasku, J; Grulichova, M; Mikes, O; Zlamal, F; Prusa, T; Pohorala, A; Andryskova, L; Pikhart, H; - view fewer (2018) Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study. Nutrition & Metabolism , 15 , Article 5. 10.1186/s12986-018-0240-8 . Green open access

https://ift.tt/2HenThy

Transcorneal electrical stimulation for the treatment of retinitis pigmentosa: results from the TESOLAUK trial

Wagner, SK; Jolly, JK; Pefkianaki, M; Gekeler, F; Webster, AR; Downes, SM; Maclaren, RE; (2017) Transcorneal electrical stimulation for the treatment of retinitis pigmentosa: results from the TESOLAUK trial. BMJ Open Ophthalmology , 2 (1) , Article e000096. 10.1136/bmjophth-2017-000096 . Green open access

https://ift.tt/2HLxKMU

Phacoemulsification plus endoscopic cyclophotocoagulation versus phacoemulsification alone in primary open-angle glaucoma

Pérez Bartolomé, F; Rodrigues, IA; Goyal, S; Bloch, E; S. Lim, W; Alaghband, P; Guajardo, J; ... S. Lim, K; + view all Pérez Bartolomé, F; Rodrigues, IA; Goyal, S; Bloch, E; S. Lim, W; Alaghband, P; Guajardo, J; Jones, S; S. Lim, K; - view fewer (2017) Phacoemulsification plus endoscopic cyclophotocoagulation versus phacoemulsification alone in primary open-angle glaucoma. European Journal of Ophthalmology 10.5301/ejo.5001034 . (In press).

https://ift.tt/2Hbz5vE

Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort

Bloch, E; Yonova-Doing, E; Jones-Odeh, E; Williams, KM; Kozareva, D; Hammond, CJ; (2017) Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort. JAMA Ophthalmology , 135 (1) pp. 31-38. 10.1001/jamaophthalmol.2016.4486 .

https://ift.tt/2HLb9As

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

Varrault, A; Dantec, C; Le Digarcher, A; Chotard, L; Bilanges, B; Parrinello, H; Dubois, E; ... Journot, L; + view all Varrault, A; Dantec, C; Le Digarcher, A; Chotard, L; Bilanges, B; Parrinello, H; Dubois, E; Rialle, S; Severac, D; Bouschet, T; Journot, L; - view fewer (2017) Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network. Nucleic Acids Research , 45 (18) pp. 10466-10480. 10.1093/nar/gkx672 . Green open access

https://ift.tt/2EWZlaU

The Neuropsychological Profile and Phenomenology of Late Onset Psychosis: A Cross-sectional Study on the Differential Diagnosis of Very-Late-Onset Schizophrenia-Like Psychosis, Dementia with Lewy Bodies and Alzheimer's Type Dementia with Psychosis

Van Assche, L; Van Aubel, E; Van de Ven, L; Bouckaert, F; Luyten, P; Vandenbulcke, M; (2018) The Neuropsychological Profile and Phenomenology of Late Onset Psychosis: A Cross-sectional Study on the Differential Diagnosis of Very-Late-Onset Schizophrenia-Like Psychosis, Dementia with Lewy Bodies and Alzheimer's Type Dementia with Psychosis. Archives of Clinical Neuropsychology 10.1093/arclin/acy034 . (In press).

https://ift.tt/2HGE6gB

Kaposi Sarcoma of the Ear in HIV-Negative Patients

https://ift.tt/2HuoMWS

Why Don’t Kids Use Their Asthma Medicines? Children, Caregivers and Clinicians Disagree on the Answer

In a new analysis of interviews conducted with children who have asthma, their caregivers and their clinicians, Johns Hopkins researchers found that there was significant lack of agreement about why the kids miss their needed daily anti-inflammatory medication.

https://ift.tt/2qDT3Ji

Kaposi Sarcoma of the Ear in HIV-Negative Patients

https://ift.tt/2JTaihL

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC min/+ mice

Abstract

Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC^min/+ mouse model. By breeding APC^min/+ mice with DEREG mice, which harbour a high affinity diphtheria toxin receptor under the control of the FOXP3 promoter, we were able to deplete Treg in tumor-bearing mice. Using adoptive transfer experiments, we could document a markedly increased migration of T cells specifically into Treg depleted tumors, and that Treg depletion results in increased production of the CXCR3 ligand CXCL10 from endothelial cells in the tumors. Furthermore, we were able to demonstrate that T cells use CXCR3 to migrate into intestinal tumors. In addition, human colon adenocarcinomas express high levels of mRNA CXCR3 ligands and tumor endothelial cells produce CXCL9 and CXCL10 ex vivo. In conclusion, this study demonstrates that Treg reduce endothelial CXCL10 production, inhibit T-cell migration into tumors and that CXCR3 mediated signalling is crucial for lymphocyte accumulation in intestinal tumors. Thus, immunotherapy aimed at Treg depletion may be effective by increasing not only T effector cell activity, but also their accumulation in tumors.

https://ift.tt/2qDybRs

IGEL Laryngeal Mask Airway Device Effectiveness in Irradiated Necks

Condition:   Laryngeal Masks
Intervention:   Device: IGEL Laryngeal mask
Sponsor:   NHS Lothian
Not yet recruiting

https://ift.tt/2JUMF8p

Comparative Study of Robot BABA Approach and Chest Breast Approach for Lateral Neck Dissection

Conditions:   Thyroid Carcinoma;   Robot Surgery;   Endoscopic Surgery
Interventions:   Device: Robot;   Device: Total endoscopic
Sponsor:   Fujian Medical University
Recruiting

https://ift.tt/2J80ZJz

Direct Electrical Current Used to Preferentially Inhibit Pain-Transmitting Neurons

Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that "direct electrical current" can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed.

https://ift.tt/2HIRwZr

Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases

Paracoccidioidomycosis is a fungal infection initially described in Brazil in 1908 by Adolfo Lutz. Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. It is characterized classically by cutaneous lesions, lymphadenopathy, and pulmonary involvement. It presents male predilection, which can be explained by the protective effect of female hormones. Classic presentation within oral cavity is a superficial ulcer characterized by hemorrhagic dots of moriform aspect. Treatment should be established individually and closely monitored. This manuscript aims at reporting five cases of this pathology.

https://ift.tt/2vpjN54

Disruptive behavior in the operating room: prevalence, consequences, prevention, and management

Purpose of review Disruptive workplace behavior can have serious consequences to clinicians, institutions, and patients. There is a range of disruptive behaviors, and the consequences are often underappreciated. The purpose of this manuscript is to review the definition, prevalence, consequences, prevention, and management of disruptive behavior in the operating room. Recent findings Although a small minority of operating room clinicians act disruptively, 98% of clinicians report having recently been exposed to disruptive behavior, with the average being 64 events per clinician per year. The causes include intrapersonal factors, workplace relationships, workplace logistics, and broader contextual factors. Disruptive behavior undermines patient care by decreasing individual and team clinical performance. It decreases clinician well being, sets a poor example for medical students who are susceptible to negative role models, and decreases hospital efficiency. The way that clinicians respond to disruptive behavior may either exacerbate or reduce the consequences of the behavior. In order to prevent disruptive behavior, the causes must be addressed. Institutions must have robust policies to deal with disruptive behavior and have preventive measures that include regular staff education. Whenever disruptive behavior does occur, it must be expeditiously addressed, which may include graded discipline. Summary Disruptive intraoperative behavior is prevalent and harms multiple parties in the operating room. Institutions require comprehensive measures to prevent the behavior and to mitigate consequences. Correspondence to Dr Eric Jacobsohn, MBChB, MHPE, FRCPC, AE215, Harry Medovy House – 671 William Avenue, Winnipeg, MB R3E 0Z2, Canada. Tel: +1 204 787 1518; e-mail: EJacobsohn@exchange.hsc.mb.ca Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2J7JXet

Islamization and trade in the Arabian Gulf in the age of Mohammad and Charlemagne

Carvajal Lopez, JC; (2017) Islamization and trade in the Arabian Gulf in the age of Mohammad and Charlemagne. In: Mitchell, J and Moreland, J and Leal, B, (eds.) Encounters, Excavations and Argosies. Essays for Richard Hodges. (pp. 73-90). Oxbow Books: Oxford, United Kingdom.

https://ift.tt/2JWZjE0

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H; Goncalves, A; Leha, A; Afzal, V; Alasoo, K; Ashford, S; Bala, S; ... Gaffney, DJ; + view all Kilpinen, H; Goncalves, A; Leha, A; Afzal, V; Alasoo, K; Ashford, S; Bala, S; Bensaddek, D; Casale, FP; Ulley, OJC; Danecek, P; Faulconbridge, A; Harrison, PW; Kathuria, A; McCarthy, D; McCarthy, SA; Meleckyte, R; Memari, Y; Moens, N; Soares, F; Mann, A; Streeter, I; Agu, CA; Alderton, A; Nelson, R; Harper, S; Patel, M; White, A; Patel, SR; Clarke, L; Halai, R; Kirton, CM; Kolb-Kokocinski, A; Beales, P; Birney, E; Danovi, D; Lamond, AI; Ouwehand, WH; Vallier, L; Watt, FM; Durbin, R; Stegle, O; Gaffney, DJ; - view fewer (2017) Common genetic variation drives molecular heterogeneity in human iPSCs. Nature , 546 (7658) pp. 370-375. 10.1038/nature22403 . Green open access

https://ift.tt/2J4TGSJ

Crowdsourcing quality control for Dark Energy Survey images

Melchior, P; Sheldon, E; Drlica-Wagner, A; Rykoff, ES; Abbott, TMC; Abdalla, FB; Allam, S; ... Zhang, Y; + view all Melchior, P; Sheldon, E; Drlica-Wagner, A; Rykoff, ES; Abbott, TMC; Abdalla, FB; Allam, S; Benoit-Levy, A; Brooks, D; Buckley-Geer, E; Carnero Rosell, A; Kind, MC; Carretero, J; Crocce, M; D'Andrea, CB; da Costa, LN; Desai, S; Doel, P; Evrard, AE; Finley, DA; Flaugher, B; Frieman, J; Gaztanaga, E; Gerdes, DW; Gruen, D; Gruendl, RA; Honscheid, K; James, DJ; Jarvis, M; Kuehn, K; Li, TS; Maia, MAG; March, M; Marshall, JL; Nord, B; Ogando, R; Plazas, AA; Romer, AK; Sanchez, E; Scarpine, V; Sevilla-Noarbe, I; Smith, RC; Soares-Santos, M; Suchyta, E; Swanson, MEC; Tarle, G; Vikram, V; Walker, AR; Wester, W; Zhang, Y; - view fewer (2016) Crowdsourcing quality control for Dark Energy Survey images. Astronomy and Computing , 16 pp. 99-108. 10.1016/j.ascom.2016.04.003 . Green open access

https://ift.tt/2JTK4eY

Data and evidence challenges facing place-based policing

Hutt, OK; Bowers, K; Johnson, S; Davies, T; (2018) Data and evidence challenges facing place-based policing. Policing: An International Journal of Police Strategies & Management 10.1108/PIJPSM-09-2017-0117 . (In press). Green open access

https://ift.tt/2J6wUdj

Roman Britain from the outside: comparing western and northern frontier cultures

Gardner, AN; (2017) Roman Britain from the outside: comparing western and northern frontier cultures. In: Gonzalez Sanchez, S and Guglielmi, A, (eds.) 'Romans' and 'barbarians' beyond the frontiers: archaeology, ideology and identities in the north. Oxbow Books: Oxford, United Kingdom.

https://ift.tt/2JTJQEE

Evaluating Dihydroazulene/Vinylheptafulvene Photoswitches for Solar Energy Storage Applications

Wang, Z; Udmark, J; Boerjesson, K; Rodrigues, R; Roffey, A; Abrahamsson, M; Nielsen, MB; Wang, Z; Udmark, J; Boerjesson, K; Rodrigues, R; Roffey, A; Abrahamsson, M; Nielsen, MB; Moth-Poulsen, K; - view fewer (2017) Evaluating Dihydroazulene/Vinylheptafulvene Photoswitches for Solar Energy Storage Applications. ChemSusChem , 10 (15) pp. 3049-3055. 10.1002/cssc.201700679 . Green open access

https://ift.tt/2HaPdNI

Ignore Mark Zuckerberg: His promise that new EU data privacy guidelines will be “rolled out” to American users is misleading

Veale, M; (2018) Ignore Mark Zuckerberg: His promise that new EU data privacy guidelines will be "rolled out" to American users is misleading. Slate

https://ift.tt/2JXxFq6

A Multi-scale Biophysical Approach to Develop Structure-Property Relationships in Oral Biofilms

Pattem, J; Davrandi, M; Aguayo, S; Allan, E; Spratt, D; Bozec, L; (2018) A Multi-scale Biophysical Approach to Develop Structure-Property Relationships in Oral Biofilms. Scientific Reports , 8 , Article 5691. 10.1038/s41598-018-23798-1 . Green open access

https://ift.tt/2H7KLiP

The Need for Sensemaking in Networked Privacy and Algorithmic Responsibility

Van Kleek, M; Seymour, W; Veale, M; Binns, R; Shadbolt, N; (2018) The Need for Sensemaking in Networked Privacy and Algorithmic Responsibility. In: (Proceedings) ACM Conference on Human Factors in Computing Systems (CHI'18). (In press). Green open access

https://ift.tt/2JXxpYa

Landscapes of Violence in Early Medieval Wessex: Towards a Reassessment of Anglo-Saxon Strategic Landscapes

Brookes, SJ; Baker, J; (2015) Landscapes of Violence in Early Medieval Wessex: Towards a Reassessment of Anglo-Saxon Strategic Landscapes. In: Lavelle, R and Roffey, S, (eds.) Danes in Wessex: The Scandinavian Impact on Southern England c 800-c 1100. Oxbow Books: Oxford, United Kingdom.

https://ift.tt/2HcVSqH

On theory-building in Roman archaeology: the potential for new approaches to materiality and practice

Gardner, AN; (2017) On theory-building in Roman archaeology: the potential for new approaches to materiality and practice. In: Van Oyen, A and Pitts, M, (eds.) Materialising Roman Histories: Beyond Instrumentalism and Representation. Oxbow Books: Oxford, United Kingdom.

https://ift.tt/2JXxevY

The association of abdominal muscle with outcomes after scheduled abdominal aortic aneurysm repair

Shah, N; Abeysundara, L; Dutta, P; Christodoulidou, M; Wylie, S; Richards, T; Schofield, N; (2017) The association of abdominal muscle with outcomes after scheduled abdominal aortic aneurysm repair. Anaesthesia , 72 (9) pp. 1107-1111. 10.1111/anae.13980 .

https://ift.tt/2J65KmQ

Efficacy of combination therapies of topical 5% imiquimod and liquid nitrogen for penile molluscum contagiosum

The Journal of Dermatology, EarlyView.


https://ift.tt/2qGBabP

Type 1 diabetes in a melanoma patient treated with ipilimumab after nivolumab

The Journal of Dermatology, EarlyView.


https://ift.tt/2Hap4mw

High-riding brachiocephalic (innominate) artery during surgical tracheostomy

Two cases of a high-riding innominate artery, which were found during routine surgical tracheostomy. A cartilage flap was applied to cover the significant vessel to prevent the life-threatening complications. These two cases were followed up for 2 months without any adverse events. We discussed the related vascular anatomy, imaging studies and brief literature review.

https://ift.tt/2qI8hNh

Rare case of hepatic haematoma following endoscopic retrograde cholangiopancreatography

Endoscopic retrograde cholangiopancreatography (ERCP) is a commonly used diagnostic and therapeutic technique but it is not free of complications. Subcapsular hepatic haematoma is a rare but potentially fatal complication. A 71-years-old male patient resorted to the emergency department 36 hours after an uneventful ERCP presenting with severe abdominal pain and haemoglobin drop. Abdominal ultrasound and CT scan diagnosed a subcapsular hepatic haematoma. The patient was haemodynamically normal and was successfully treated with a conservative management. Signs and symptoms of hepatic haematoma following ERCP are non-specific. The most common symptom is abdominal pain. Abdominal CT, ultrasound or MRI make the diagnosis. Conservative management is possible if the patient is stable, nevertheless invasive treatment such as surgery or angiographic embolisation, may be required. A low threshold of suspicion is crucial for an early diagnosis and treatment. Fatal cases have been described but most patients have a favourable outcome.

https://ift.tt/2qGhVQB

Transverse testicular ectopia with persistent mullerian duct syndrome

Persistent mullerian duct syndrome (PMDS) is a rare form of male pseudohermaphroditism caused by defects in synthesis or actions of mullerian inhibiting factor characterised by persistence of mullerian duct structures in a normal karyotype male. Transverse testicular ectopia (TTE) is a rare disease in which both testes are located in the same inguinal canal. We report a case of PMDS with TTE in a 1-year-old child who presented with non-palpable testis on right side with hernia on left side. Left herniotomy with bilateral trans-septal orchidopexy was done in this patient.

https://ift.tt/2vonHek

Ribavirin-induced anaemia reduced tacrolimus level in a hepatitis C patient receiving haemodialysis

A 37-year-old man with hepatitis C virus (HCV) genotype 3A developed renal failure. In 2007, the patient received a renal transplant and started receiving tacrolimus (Tac); the transplant subsequently failed. In April 2015, the patient restarted haemodialysis and in May initiated sofosbuvir 400 mg and ribavirin 400 mg daily. Baseline Tac level was 6.6 ng/mL and haemoglobin (Hb) was 10.3 g/dL. The patient then left the country for vacation and Hb was found to be dramatically low at 3.7 g/dL on return on 5 August. Ribavirin was put on hold, while darbepoetin dose was increased. On 23 August, Tac level was found undetectable; hence, dosage was increased. Hb eventually bounced back to >10 g/dL in October and Tac to 7.2 ng/mL; ribavirin was restarted at 200 mg three times weekly. HCV RNA level was undetectable at 3 months and remained undetectable 12 weeks after therapy finished.

https://ift.tt/2Hw6FQ8

A case of autoimmune haemolytic anaemia after 39 cycles of nivolumab

With growing use of nivolumab, rare but serious side effects have surfaced in some patients. We present a case of autoimmune haemolytic anaemia that developed after 39 cycles of nivolumab. A 78-year-old man with metastatic lung adenocarcinoma, refractory to multiple lines of chemotherapy was switched to nivolumab. After around 2 years of stable course on nivolumab, he developed transfusion-dependent anaemia with haemoglobin of 8.6 g/dL. Nivolumab was held immediately. Bone marrow biopsy findings were inconclusive of myelodysplastic syndrome. Further testing was suggestive of haemolysis with haptoglobin <10 mg/dL, elevated reticulocyte count and identification of immunoglobulin G antibody. Haemoglobin improved significantly with initiation of 1 mg/kg prednisone in addition to rituximab weekly x four doses. The development of transfusion-dependent anaemia with the exposure to cytotoxic chemotherapy usually raises the question for myelodysplastic syndrome. In contradiction, our patient was diagnosed to have a haematological autoimmune complication related to immunotherapy.

https://ift.tt/2J1eOJF

Haematometrocolpos and acute pelvic pain associated with cyclic uterine bleeding: OHVIRA syndrome

Obstructed hemivagina and ipsilateral renal agenesis syndrome is a complex urogenital malformation usually presenting with obstructed menses and pelvic pain during female adolescence. The diagnosis can be established preoperatively with relative certainty by MRI or ultrasonography, and outcomes are usually satisfactory following surgical resection of the septal portion of the obstructed hemivagina. Such cases are best managed in referral centres with expertise in anatomical disorders of the female genital tract.

https://ift.tt/2qGhQMN

A case of H3N2 complicated by acute kidney injury secondary to rhabdomyolysis

H3N2 was first detected in July 2011 in the USA. It is responsible for sporadic cases of influenza and localised outbreaks and has not yet taken over on an epidemic or pandemic scale. An 84-year-old man presented with a dry cough, fever and myalgia for 3 days. On examination, he had a pulse of 98 bpm and blood pressure of 124/88 mm Hg. The patient was tachypnoeic, SpO₂ was 90%. Auscultation revealed bilateral diffuse wheeze and crackles. He had generalised muscle tenderness on examination. On admission, creatinine was 1.9 mg/dL and CK(creatine kinase) was 44 000 U/L. Chest X-ray was suggestive of ARDS (acute respiratory distress syndrome). Throat swab was positive for H3N2. The patient was given intravenous fluids, oral sodium bicarbonate, oxygen and oseltamivir tablet. In view of ARDS, he was given intravenous methylprednisolone and bronchodilators for bronchospasm. The patient improved symptomatically; vitals and lab reports were normal at the time of discharge.

https://ift.tt/2vn8qud

Hydroxychloroquine-induced hypoglycaemia in non-diabetic renal patient on peritoneal dialysis

Hydroxychloroquine (HCQ) is a commonly used drug for the treatment of systemic lupus erythematosus (SLE). Renal involvement is common in SLE. We present a 25-year-old woman with lupus nephritis on peritoneal dialysis whose lupus was quite silent for almost three years, and secondary to HCQ she developed severe hypoglycaemic episodes, which were completely resolved after stopping HCQ.

https://ift.tt/2HsqYhw

Transient immune-mediated agranulocytosis following Mycoplasma pneumoniae infection

Mycoplasma pneumoniae is a common respiratory pathogen which may cause haematological manifestations including haemolytic anaemia and thrombocytopaenia. Severe neutropaenia is rare with very few cases reported in the literature. An 85-year-old man was transferred to our facility with agranulocytosis in the context of an infective exacerbation of chronic obstructive pulmonary disease with positive serological testing for M. pneumoniae. No alternative infective, autoimmune or lymphoproliferative cause of the neutropaenia was identified. Granulocyte autoantibody testing was performed with a positive result for neutrophil-bound IgG and IgM autoantibodies and significant agglutination reactions. The patient was treated with azithromycin and granulocyte colony-stimulating factor which resulted in a sustained resolution of his neutropaenia.

https://ift.tt/2J497KY

Nasal septal schwannoma: a rare sinonasal tumour with certain peculiarities

Sinonasal schwannomas constitute 4% of head and neck nerve sheath tumours; however, schwannomas involving the nasal septum are quite rare. We present a 57-year-old male patient with nasal septal schwannoma who was managed successfully by endoscopic excision. 32 cases of septal schwannoma have been reported so far in the literature. This report discusses certain peculiar features exhibited by schwannomas of the nasal septum. Septal schwannoma does not show any age, sex or side predilection. However, they tend to involve posterior part of the septum and presumed to arise from the nasopalatine branch of the trigeminal nerve. Imaging findings of the sinonasal schwannoma are non-specific, but the histopathological characteristics are diagnostic, with seldom need for immunohistochemistry. Endoscopic excision is the safe and effective treatment option for the septal schwannoma of any size and location. Recurrence has not been reported in the literature following endoscopic excision.

https://ift.tt/2qLX8v5

Lemierres syndrome: cavitary lung disease caused by uncommon bacteria

Description 

A 32-year-old Asian man with a history of gastritis presented to the emergency room with abdominal pain, fever, cough and dyspnoea, one episode of haemoptysis. He also reported a sore throat 3 days ago. The patient was a sushi chef and an active smoker. Early lab work was remarkable for leucocytosis of 21 x10⁹/L, lactic acidosis of 3 mmol/L, bandaemia of 19% with a procalcitonin of >100 and platelets of 74 x10⁹/L . CT of the lungs was performed without contrast and was significant for multiple cavity lesions throughout the lungs (figures 1 and 2). The patient was intubated due to respiratory failure. He was empirically started on vancomycin, cefepime and azithromycin. A right internal jugular central line was attempted for triple lumen catheter placement but the vessel was not compressible. A CT scan of the neck revealed a right internal jugular vein 9 mm thrombosis (figure 3). Blood culture grew Fusobacterium necrophorum....

https://ift.tt/2vnJJOl

Seizure-Associated ST Elevation Myocardial Infarction in Absence of Plaque Rupture

Acute coronary syndrome (ACS) is a very common cause of morbidity and mortality in the U.S. Here, we present a case of acute ST elevation myocardial infarction (STEMI) in the setting of seizure activity. In this rare case, we have data from optical coherence tomography (OCT) that showed no plaque disruption, showing the role of OCT in understanding the pathophysiology of STEMI and providing some ideas for the mechanism of this seizure-induced STEMI.

https://ift.tt/2H91TEX

Aflatoxin M 1 contamination of raw cow’s milk in five regions of Kosovo during 2016

Abstract

During February and August 2016 (winter and summer season), 192 samples of raw bulk tank milk have been collected from small dairy farms in five different regions of Kosova (Prishtina, Prizren, Peja, Mitrovica, and Gjilan). These samples were analyzed for aflatoxin M₁ (AFM₁) contamination level by ultra-high performance liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UHPLC–ESI–MS/MS). The limit of quantification for AFM1 was 0.02 μg/L and recovery at 0.1–0.5 μg/L was 90–95% (coefficient of variation 15–25%). A total of 74 milk samples (38%) were found to be contaminated with AFM₁ and 11 samples (5.7%) slightly exceeded the European Union maximum level of 0.05 μg/L. The maximum AFM₁ level was at 0.082 μg/L. There was no relevant difference between summer and winter with regard to AFM₁ frequency and levels. Although the frequency of AFM₁-positive samples varied between regions, from 7% (Prishtina) to 53% (Prizren), only minor regional differences were observed with regard to average and maximum toxin levels. The high percentage of milk samples which were non-compliant with AFM₁ maximum levels indicates that efforts to reduce the contamination levels of aflatoxin B₁ in cows feed in Kosovo are necessary.

https://ift.tt/2H7EZ4Z

Anaesthesia in High-Risk Patients

No abstract available

https://ift.tt/2J18JwP

Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers

Abstract

DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers. SGT included: acinic cell carcinoma (ACC, n = 15), secretory carcinoma (SC, n = 9), pleomorphic adenoma (PA, n = 49), carcinoma ex-PA (Ca ex-PA, n = 11), adenoid cystic carcinoma (AdCC, n = 20), polymorphous adenocarcinoma (PAC, n = 6), myoepithelioma (n = 6), myoepithelial carcinoma (MC, n = 2), basal cell adenoma (BCA, n = 14), canalicular adenoma (CA, n = 19), mucoepidermoid carcinoma (MEC, n = 11), oncocytoma (n = 2), adenocarcinoma NOS (AdNOS, n = 4), basal cell adenocarcinoma (BCAC, n = 2), salivary duct carcinoma (SDC, n = 3) and papillary cystadenocarcinoma (PCAC, n = 1). Normal acini and ACC (14/15) showed strong luminal DOG1 staining; SC were largely negative with only focal expression in 3/9 cases. Luminal staining was seen in PA (14/49), PAC (4/6), Ca ex-PA (4/11) and AdCC (6/20). 8/11 MEC showed luminal and/or mucous cell staining. No staining was seen in myoepithelioma, MC, CA, adNOS and BCAC. BCA showed strong staining of myoepithelial cells in some cases (5/14). Variable myoepithelial DOG1 staining was seen in PA, Ca ex PA, BCA, SDC and PCAC which was not as consistent as myoepithelial markers such as calponin, p63 and αSMA. Absence of DOG1 can differentiate ACC from SC, but staining is variable in PA, PLGA and Ca ex-PA. Myoepithelial staining in some tumours but not in normal gland suggests a wider distribution in SGT than originally envisaged.

https://ift.tt/2H7hHw5

Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India

Abstract

Chronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12 years (2006–2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study. Age of the patients ranged from 12 to 75 years (mean age: 37.1 ± 22.7 years). Of 15 cases, 9 (60.0%) were males and 6 (40.0%) were females. It was a unilateral presentation in all. The complaints observed were ear discharge in all followed by itching (86.7%), pain (46.7%), decreased hearing (26.7%) and blocking sensation (13.3%). Histomorphologic typing of fungus was possible in 13/15 patients. Isolated aspergillus was identified in eight patients while mucor alone was seen in three patients. Mixed infection with Aspergillus + Candida and Aspergillus + Mucor was seen in one patient each. Categorization of fungus could not be done in rest of the two patients due to paucity of fungal profiles. Histopathological identification of fungal organisms in otomycosis provides a quick and fairly reliable diagnosis. Culture is considered the gold standard but it may not always be available or fruitful. Less turnaround time and accurate diagnosis facilitates prompt and optimal therapy in fungal otitis media thus preventing adverse outcomes.

https://ift.tt/2qHaOq5

Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers

Abstract

DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers. SGT included: acinic cell carcinoma (ACC, n = 15), secretory carcinoma (SC, n = 9), pleomorphic adenoma (PA, n = 49), carcinoma ex-PA (Ca ex-PA, n = 11), adenoid cystic carcinoma (AdCC, n = 20), polymorphous adenocarcinoma (PAC, n = 6), myoepithelioma (n = 6), myoepithelial carcinoma (MC, n = 2), basal cell adenoma (BCA, n = 14), canalicular adenoma (CA, n = 19), mucoepidermoid carcinoma (MEC, n = 11), oncocytoma (n = 2), adenocarcinoma NOS (AdNOS, n = 4), basal cell adenocarcinoma (BCAC, n = 2), salivary duct carcinoma (SDC, n = 3) and papillary cystadenocarcinoma (PCAC, n = 1). Normal acini and ACC (14/15) showed strong luminal DOG1 staining; SC were largely negative with only focal expression in 3/9 cases. Luminal staining was seen in PA (14/49), PAC (4/6), Ca ex-PA (4/11) and AdCC (6/20). 8/11 MEC showed luminal and/or mucous cell staining. No staining was seen in myoepithelioma, MC, CA, adNOS and BCAC. BCA showed strong staining of myoepithelial cells in some cases (5/14). Variable myoepithelial DOG1 staining was seen in PA, Ca ex PA, BCA, SDC and PCAC which was not as consistent as myoepithelial markers such as calponin, p63 and αSMA. Absence of DOG1 can differentiate ACC from SC, but staining is variable in PA, PLGA and Ca ex-PA. Myoepithelial staining in some tumours but not in normal gland suggests a wider distribution in SGT than originally envisaged.

https://ift.tt/2H7hHw5

Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India

Abstract

Chronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12 years (2006–2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study. Age of the patients ranged from 12 to 75 years (mean age: 37.1 ± 22.7 years). Of 15 cases, 9 (60.0%) were males and 6 (40.0%) were females. It was a unilateral presentation in all. The complaints observed were ear discharge in all followed by itching (86.7%), pain (46.7%), decreased hearing (26.7%) and blocking sensation (13.3%). Histomorphologic typing of fungus was possible in 13/15 patients. Isolated aspergillus was identified in eight patients while mucor alone was seen in three patients. Mixed infection with Aspergillus + Candida and Aspergillus + Mucor was seen in one patient each. Categorization of fungus could not be done in rest of the two patients due to paucity of fungal profiles. Histopathological identification of fungal organisms in otomycosis provides a quick and fairly reliable diagnosis. Culture is considered the gold standard but it may not always be available or fruitful. Less turnaround time and accurate diagnosis facilitates prompt and optimal therapy in fungal otitis media thus preventing adverse outcomes.

https://ift.tt/2qHaOq5

The social condenser: again, again and again—the case for the Narkomfin Communal House, Moscow

Buchli, V; (2017) The social condenser: again, again and again—the case for the Narkomfin Communal House, Moscow. The Journal of Architecture , 22 (3) pp. 387-402. 10.1080/13602365.2017.1326679 .

https://ift.tt/2H9GHTc

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Kishore, M; Cheung, KCP; Fu, H; Bonacina, F; Wang, G; Coe, D; Ward, EJ; ... Marelli-Berg, FM; + view all Kishore, M; Cheung, KCP; Fu, H; Bonacina, F; Wang, G; Coe, D; Ward, EJ; Colamatteo, A; Jangani, M; Baragetti, A; Matarese, G; Smith, DM; Haas, R; Mauro, C; Wraith, DC; Okkenhaug, K; Catapano, AL; De Rosa, V; Norata, GD; Marelli-Berg, FM; - view fewer (2017) Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity , 47 (5) 875-889.e10. 10.1016/j.immuni.2017.10.017 . Green open access

https://ift.tt/2qGDm2Y

Production of a fluorescence resonance energy transfer (FRET) biosensor membrane for microRNA detection

Fu, Y; Chen, T; Wang, G; Gu, T; Xie, C; Huang, J; Li, X; ... Han, G; + view all Fu, Y; Chen, T; Wang, G; Gu, T; Xie, C; Huang, J; Li, X; Best, S; Han, G; - view fewer (2017) Production of a fluorescence resonance energy transfer (FRET) biosensor membrane for microRNA detection. Journal of Materials Chemistry B , 5 (34) pp. 7133-7139. 10.1039/c7tb01399j .

https://ift.tt/2HaecoN

Experimental study of beam distortion due to fiducial markers during salvage HIFU in the prostate

Bakaric, M; Martin, E; S Georgiou, P; T Cox, B; Payne, H; E Treeby, B; (2018) Experimental study of beam distortion due to fiducial markers during salvage HIFU in the prostate. Journal of Therapeutic Ultrasound , 6 , Article 1. 10.1186/s40349-018-0109-3 . Green open access

https://ift.tt/2qGjInP

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

Nadkarni, S; Smith, J; Sferruzzi-Perri, AN; Ledwozyw, A; Kishore, M; Haas, R; Mauro, C; ... Perretti, M; + view all Nadkarni, S; Smith, J; Sferruzzi-Perri, AN; Ledwozyw, A; Kishore, M; Haas, R; Mauro, C; Williams, DJ; Farsky, SHP; Marelli-Berg, FM; Perretti, M; - view fewer (2016) Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy. Proceedings of the National Academy of Sciences of the United States of America , 113 (52) E8415-E8424. 10.1073/pnas.1611944114 . Green open access

https://ift.tt/2HceIlO

Generation of an arrayed CRISPR-Cas9 library targeting epigenetic regulators: from high-content screens to in vivo assays

Henser-Brownhill, T; Monserrat, J; Scaffidi, P; (2017) Generation of an arrayed CRISPR-Cas9 library targeting epigenetic regulators: from high-content screens to in vivo assays. Epigenetics , 12 (12) pp. 1065-1075. 10.1080/15592294.2017.1395121 . Green open access

https://ift.tt/2qKxh5U

Luminescent CaTiO3:Yb,Er nanofibers co-conjugated with Rose Bengal and gold nanorods for potential synergistic photodynamic/photothermal therapy

Fu, Y; Liu, H; Ren, Z; Li, X; Huang, J; Best, S; Han, G; (2017) Luminescent CaTiO3:Yb,Er nanofibers co-conjugated with Rose Bengal and gold nanorods for potential synergistic photodynamic/photothermal therapy. Journal of Materials Chemistry B , 5 (26) pp. 5128-5136. 10.1039/c7tb01165b .

https://ift.tt/2HbWb9l

Improvement Science in Anaesthesia

Wagstaff, DT; Bedford, J; Moonesinghe, SR; (2017) Improvement Science in Anaesthesia. Current Anesthesiology Reports , 7 (4) pp. 432-439. 10.1007/s40140-017-0234-5 . Green open access

https://ift.tt/2qHeTKV

Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women

Batty, GD; Jung, KJ; Lee, S; Back, JH; Jee, SH; (2018) Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women. Journal of Epidemiology & Community Health 10.1136/jech-2017-210086 . (In press). Green open access

https://ift.tt/2H8bNe3

Facilitating fluency in adults who stutter

Crinion, JT; (2018) Facilitating fluency in adults who stutter. Brain , 141 (4) pp. 944-946. 10.1093/brain/awy075 . Green open access

https://ift.tt/2qFcRLx

Missing data in trial-based cost-effectiveness analysis: An incomplete journey

Leurent, B; Gomes, M; Carpenter, JR; (2018) Missing data in trial-based cost-effectiveness analysis: An incomplete journey. Health Economics 10.1002/hec.3654 . (In press). Green open access

https://ift.tt/2H8sshE

Fault-tolerant quantum computation with nondeterministic entangling gates

Auger, JM; Anwar, H; Gimeno-Segovia, M; Stace, TM; Browne, DE; (2018) Fault-tolerant quantum computation with nondeterministic entangling gates. Physical Review A , 97 (3) , Article 030301. 10.1103/PhysRevA.97.030301 . Green open access

https://ift.tt/2qIFuam

Flipping 419 Cybercrime Scams: Targeting the Weak and the Vulnerable

Mba, G; Onaolapo, J; Stringhini, G; Cavallaro, L; (2017) Flipping 419 Cybercrime Scams: Targeting the Weak and the Vulnerable. In: Barrett, R and Cummings, R and Agichtein, E and Gabrilovich, E, (eds.) Proceedings of the 26th International Conference on World Wide Web Companion. (pp. pp. 1301-1310). ACM Green open access

https://ift.tt/2H9lSHP

Improving number abilities in low achieving preschoolers: symbolic versus non-symbolic training programs

Van Herwegen, J; Costa, H; Nicholson, B; Donlan, C; (2018) Improving number abilities in low achieving preschoolers: symbolic versus non-symbolic training programs. Research in Developmental Disabilities , 77 pp. 1-11. 10.1016/j.ridd.2018.03.011 .

https://ift.tt/2qI5geX

An Investigation of General Dental Practitioners' Understanding and Perceptions of Minimally Invasive Dentistry

Mirsiaghi, F; Leung, A; Fine, PD; Blizard, B; Louca, C; (2018) An Investigation of General Dental Practitioners' Understanding and Perceptions of Minimally Invasive Dentistry. British Dental Journal (In press).

https://ift.tt/2HceDi0

Recognition memory and featural similarity between concepts: the pupil’s point of view

Montefinese, M; Vinson, D; Ambrosini, E; (2018) Recognition memory and featural similarity between concepts: the pupil's point of view. Biological Psychology (In press).

https://ift.tt/2qGSHkl

Perioperative Patient Blood Management to Improve Outcomes

Desai, N; Schofield, N; Richards, T; (2017) Perioperative Patient Blood Management to Improve Outcomes. Anesthesia & Analgesia 10.1213/ANE.0000000000002549 . (In press).

https://ift.tt/2H9l59P

Freud’s superpotential in general relativity and in Einstein-Cartan theory

Bohmer, CG; Hehl, FW; (2018) Freud's superpotential in general relativity and in Einstein-Cartan theory. Physical Review D , 97 (4) , Article 044028. 10.1103/PhysRevD.97.044028 . Green open access

https://ift.tt/2qH3SJv

Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging

Parker, TD; Slattery, CF; Zhang, J; Nicholas, JM; Paterson, RW; Foulkes, AJM; Malone, IB; ... Schott, JM; + view all Parker, TD; Slattery, CF; Zhang, J; Nicholas, JM; Paterson, RW; Foulkes, AJM; Malone, IB; Thomas, DL; Modat, M; Cash, DM; Crutch, SJ; Alexander, DC; Ourselin, S; Fox, NC; Zhang, H; Schott, JM; - view fewer (2018) Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging. Human Brain Mapping 10.1002/hbm.24056 . (In press). Green open access

https://ift.tt/2H8s170

Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis

Rao, M; Valentini, D; Zumla, A; Maeurer, M; (2018) Evaluation of the efficacy of valproic acid and suberoylanilide hydroxamic acid (vorinostat) in enhancing the effects of first-line tuberculosis drugs against intracellular Mycobacterium tuberculosis. International Journal of Infectious Diseases , 69 pp. 78-84. 10.1016/j.ijid.2018.02.021 . Green open access

https://ift.tt/2qKwa6e