The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta‐analysis

Helicobacter, EarlyView.


https://ift.tt/2MRBna6

Pemphigus vulgaris as the first manifestation of multiple myeloma: a case report

The association between pemphigus and malignancy has been well documented for decades but an association between pemphigus vulgaris and multiple myeloma is unusual. We report a case of pemphigus vulgaris revea...

https://ift.tt/2MTrrN7

Untersuchung der Qualität der Hörgeräteversorgung bei Senioren unter Berücksichtigung kognitiver Einflussfaktoren

Laryngo-Rhino-Otol
DOI: 10.1055/a-0671-2295

In der Gruppe der über 65-Jährigen ist die Hörminderung eines der häufigsten gesundheitlichen Probleme. Um die Kommunikationsfähigkeit in dieser Population aufrecht zu erhalten, ist eine adäquate Hörgeräteversorgung essentiell. Das Ziel der vorliegenden Studie war die Überprüfung der Qualität der Hörgeräteversorgung bei Senioren in Bezug auf die Wiederherstellung der Sprachdiskrimination. Weiterhin sollte der Einfluss des Alters und einiger kognitiver Parameter auf das Sprachverstehen betrachtet werden. Es wurden 40 Probanden im Alter von 66 bis 88 Jahren mit ein- oder beidseitiger Hörgeräteversorgung untersucht. Es wurde der gemittelte Hörverlust der Frequenzen 0,5–1-2–4 kHz und der gemittelte Hochton-Hörverlust bei den Frequenzen 2–4-6 kHz sowie das maximale Einsilberverstehen (mEV) und das hörgeräteversorgte Sprachverstehen bei 65 dB betrachtet. Um mögliche kognitive Einflussfaktoren zu ermitteln, wurden ein Demenzscreening-Verfahren (DemTect-Test) und ein Test zur Prüfung des Arbeitsgedächtnisses angewendet. Zwar zeigte sich ein Gewinn durch die Hörgeräteversorgung in 82 % der untersuchten Fälle, die nach Hilfsmittelrichtlinie geforderte Verbesserung von mindestens 20 % gegenüber der unversorgten Situation wurde jedoch in 56 % der Fälle nicht erreicht. Weiterhin wurde das individuelle mEV mit Abweichung von höchstens zehn Prozentpunkten von 81 % aller Fälle nicht erreicht. Signifikante Korrelationen zwischen Zahlenfolgen-Merkspanne bzw. DemTect-Ergebnis und mEV konnten nicht festgestellt werden. Im untersuchten Probandenkollektiv ergaben sich auch keine Hinweise für eine Abhängigkeit des Ergebnisses der Hörgeräteversorgung vom Lebensalter oder von (milder) kognitiver Beeinträchtigung sowie reduzierter Arbeitsgedächtnisleistung.
[...]

Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

https://ift.tt/2CrbuJj

Tofacitinib for the Treatment of Alopecia Areata in Preadolescent Children

https://ift.tt/2M7P3IZ

Reply to MS#JAAD-D-18-01527

https://ift.tt/2NlILKe

Ruxolitinib for the treatment of severe alopecia areata

https://ift.tt/2wMx8Sr

Lightening Becker’s nevus: Role of topical therapies

https://ift.tt/2NpP6Ev

Trichloroacetic acid as a treatment for persistent oral mucosal lesions in pemphigus vulgaris

https://ift.tt/2wPvBuP

Previously undiagnosed Darier disease complicated by bilateral ecthyma gangrenosum masquerading as a vasculopathy with retiform eschar formation

We present the case of a 57-year-old incarcerated man with a history of hepatitis C and life-long presumed atopic dermatitis who presented with a two month history of painful, progressive, ulcerations with overlying eschars on his bilateral lower extremities. He had been treated unsuccessfully with oral trimethoprim-sulfamethoxazole and clindamycin before admission. Upon admission, he was found to have leukocytosis but was otherwise hemodynamically stable and afebrile. On exam, he had erythematous hyperkeratotic papules coalescing into plaques on the neck, chest, abdomen, back, and extremities, with a flexural predominance, and retiform ulcerations with overlying eschars on the bilateral lower legs.

https://ift.tt/2NlIHtY

Onychogryphosis: A case report and review of the literature

Patient history: A 67-year-old man presented with a 30-year history of severe thickening, curving, and yellow discoloration of his left great toenail. He stated that the nail broke off midway and regrew every six months. It had become more painful recently and was impinging on his second toe, making it difficult to walk and put on socks. There is no history of trauma, tinea pedis or family history of onychomycosis. Physical examination was notable for thickening and lateral deviation of the left first toenail.

https://ift.tt/2M5aTNa

Peristomal pyoderma gangrenosum in a patient with chronic ulcerative colitis: Case report

Introduction: Peristomal pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that could be difficult to diagnose and treat. A painful necrotic ulcer surrounding an area of abdominal stoma with rapidly progression is the clinical hallmark. It is almost exclusively associated with inflammatory bowel disease (IBD). In this report, we present a 63-year-old man previously diagnosed of chronic ulcerative colitis (CUC) that develop a peristomal pyoderma gangrenosum 2 years after surgery.

https://ift.tt/2MW7HZl

Necrotisans erythema nodosum leprosum with systemic manifestations

Introduction: Erythema nodosum leprosum (ENL) is an acute reaction that generally occurs during the treatment of multibacillary leprosy. Severe cases can lead to necrotic ulcers and cause extra cutaneous manifestations. One case of necrotisans erythema nodosum leprosum (NENL) is reported to show that leprosy late diagnosis and treatment can cause severe cutaneous and systemic manifestations.

https://ift.tt/2wNqivJ

Pruritus in patients under targeted anticancer therapy: Multidimensional analysis using the 5-D itch scale

Background: Pruritus is very common symptom in patients under anticancer therapy. However, the characteristics of pruritus according to anticancer agents have not been known well.

https://ift.tt/2Nuf4qF

Platelet-rich plasma for skin rejuvenation: A systematic review of the clinical evidence

Background: Recently, platelet-rich plasma (PRP) has been used as an off-label treatment for a variety of clinical conditions including skin rejuvenation (SR). The effectiveness of PRP for SR is unclear due to lack of standardization for PRP administration. We aimed to assess the level of evidence (LOE) for safety and efficacy of PRP for SR.

https://ift.tt/2wPx7x0

Patient experience of the “two-week wait” cancer referral pathway in a large secondary care department in England

Background: The 2-week wait (2WW) system has been implemented across the NHS in England to enable rapid referral of patients with squamous cell carcinoma and malignant melanoma from primary to secondary care. Patients are told that the referral is to exclude skin cancer. In our secondary care dermatology department, a 2-week lag between referral and dermatology consultation represents a 19-week reduction in wait time (WT) from a standard referral. Little is currently known about the patients' perception of this streamlining, how WT impacts patient quality of life, and how appropriate patients consider this WT when being referred for suspected malignancy.

https://ift.tt/2MUBKki

Nonmelanoma skin cancer in HIV-positive patients: A six-year single-institution retrospective review

Background: HIV-positive (HIV+) patients have been demonstrated to have an increased incidence of nonmelanoma skin cancer (NMSC) at 2.1-2.8 times the rate found in HIV negative (HIV-) populations. Rates of NMSC with aggressive subclinical extension (ASE), defined as extensive subclinical tumor spread revealed during Mohs micrographic surgery (MMS), have not been found to be significantly different in HIV+ and HIV− populations in a previous study. However, HIV disease progression (CD4 and CD8 levels and viral load) and NMSC characteristics and their relationship to presence of NMSC with ASE within the HIV+ population remain unclear.

https://ift.tt/2M50e4U

Process of standardized postoperative telephone follow-up implementation for Mohs micrographic surgery

Mohs micrographic surgery (MMS) is an effective outpatient procedure for skin cancer removal with low reported complication rates. Identifying both major and minor postoperative complications is necessary to improve the quality of Mohs-based surgical care. There are currently no established standards for regular patient follow-up after MMS. Therefore, there exists a need to determine standardized, cost-effective, and reproducible follow-up strategies. The objective of this study was to determine whether routine telephone follow-up is an effective tool to capture postoperative complications and other patient-reported concerns.

https://ift.tt/2NovQXW

Predicting therapy outcome by HLA-Cw6 genotyping in psoriasis patients treated with secukinumab

Introduction: A possible correlation of genetic markers and response to treatment has been proclaimed. The strongest association has been shown between HLA-Cw6 and ustekinumab. So far it is unclear whether this effect can be also found in IL-17.

https://ift.tt/2M8A6WO

Pigmented eccrine poroma: A clinical dermoscopy challenge

Eccrine poroma is a benign neoplasia originated from the intraepidermal portion of the sweat gland duct. It is characterized by a papule, plaque or nodule, normochromic or erythematous, exophytic or hyperkeratotic. Although its pathogenesis is still unknown, it seems to be related to radiation, trauma or scars. The pigmented variant, more frequent in blacks and affecting mainly nonacral areas, is responsible for 17% of the cases. Various clinical-dermatoscopic features have been described, directing its differential diagnosis to other benign and malignant neoplasia, such as seborrheic keratosis, epithelized pyogenic granuloma, basal-cell and squamous-cell carcinoma, angiofibroma, and melanoma.

https://ift.tt/2MUBIZI

Pediatric melanoma immunotherapy: A retrospective examination of a decade of clinical experience at a tertiary care center

Background: Pediatric or adolescent melanoma, defined as melanoma in patients below age 20, is an infrequent occurrence that represents 0.4% of the approximately 87,110 new cases of melanoma diagnosed in the United States annually. As a result, few data exist to guide therapy that prolong survival, in particular with more recently developed immune therapies, such as immune checkpoint inhibitors. This lack of data is especially important as there is growing evidence that pediatric melanoma differs in its presentation, gene expression, and behavior from adult melanoma, and that response to therapy may vary by age.

https://ift.tt/2wS5cwe

Painful subcutaneous lesions in a patient with metastatic melanoma

Introduction: We present the case of a patient with metastatic melanoma (MM) treated with combined therapy (vemurafenib + cobimetinib), who develops painful subcutaneous lesions compatible with secondary panniculitis.

https://ift.tt/2MUwAos

Old is gold—Revisiting the efficacy of topical psoralen–ultraviolet A phototherapy for palmoplantar dermatoses

Palmoplantar involvement of dermatoses such as atopic dermatitis and psoriasis has significant impact on quality of life. While systemic treatment options have increased in recent years, topical psoralen ultraviolet A (tPUVA) therapy remains a viable option when topical treatments have failed and potential systemic adverse events outweigh benefits. Literature on tPUVA efficacy is sparse. Our objectives were to report the efficacy of tPUVA after an initial treatment course and to identify associated clinical factors.

https://ift.tt/2M7nnDK

Nicolau syndrome appears after filling hyaluronic acid with the use of blanching technique

A 34-year-old woman was treated in our clinic for mild acne and scars. Two years before, oral isotretinoin was given to the patient with a complete healing of the acne but numerous 2–3-mm scars remained in both cheeks. Two sessions of a nonablative CO2 laser was performed one year after the termination of the isotretinoin treatment with partial improvement of the scars. After that, a blanching technique with hyaluronic acid was offered to the patient. She was injected with a low reticulated hyaluronic acid with lidocaine using a 30 Gy needle doing a blanching technique to fill the scars presented in her cheeks.

https://ift.tt/2MSvedV

Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish

ABSTRACT

Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5–7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10–15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms⁻². Larval zebrafish also exhibited decreased habituation to startle-inducing stimuli following noise exposure. The noise-induced sensitization was not due to changes in absolute hearing thresholds, but was specific to the auditory-evoked escape responses. The observed noise-induced sensitization was disrupted by AMPA receptor blockade using DNQX, but not NMDA receptor blockade. Together, these experiments suggest a complex effect of noise exposure on the neural circuits mediating auditory-evoked behaviors in larval zebrafish.

https://ift.tt/2NSJ1O1

The Stress Response in the Non-sensory Cells of the Cochlea Under Pathological Conditions—Possible Role in Mediating Noise Vulnerability

Abstract

Various stressors, such as loud sounds and the effects of aging, impair the function and viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological changes in the cochlear non-sensory cells as well. We have here studied the stress response mounted in the lateral wall of the cochlea during acute noise stress and during age-related chronic stress. We have used the activation of JNK/c-Jun, ERK, and NF-κB pathways as a readout of the stress response, and the expression of the FoxO3 transcription factor as a possible additional player in cellular stress. In the aging cochlea, NF-κB transcriptional activity was strongly induced in the stria vascularis of the lateral wall. This induction was linked with the atrophy of the stria vascularis, suggesting a role for NF-κB signaling in mediating age-related strial degeneration. Acutely following noise exposure, the JNK/c-Jun, ERK, and NF-κB pathways were activated in the spiral ligament of the lateral wall of CBA/Ca mice. This activation was concomitant with the morphological transformation of macrophages, suggesting that the upregulation of stress signaling leads to macrophage activation. In contrast, C57BL/6J mice lacked these responses. Only the combination of noise exposure and a systemic stressor, lipopolysaccharide, exceeded the threshold for the activation of stress signaling in the lateral wall of C57BL/6J mice. In addition, we found that, at the young adult age, outer hair cells of CBA/Ca mice are much more vulnerable to loud sounds compared to these cells of C57BL/6J mice. These results suggest that the differential stress response in the lateral wall of the two mouse strains underlies, in part, the differential noise vulnerability of their outer hair cells. Together, we propose that the molecular stress response in the lateral wall modulates the outcome of the stressed cochlea.

https://ift.tt/2wQcoKm

The RNA-Specific Adenosine Deaminase ADAR1 Inhibits Human Protein Kinase R Activation

Viral Immunology, Volume 31, Issue 7, Page 537-538, September 2018.


https://ift.tt/2CtLlcQ

Interaction of S17 Antibody with the Functional Binding Region of the Hepatitis B Virus Pre-S2 Epitope

Viral Immunology, Volume 31, Issue 7, Page 492-499, September 2018.


https://ift.tt/2wQOf6d

Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish

ABSTRACT

Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5–7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10–15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms⁻². Larval zebrafish also exhibited decreased habituation to startle-inducing stimuli following noise exposure. The noise-induced sensitization was not due to changes in absolute hearing thresholds, but was specific to the auditory-evoked escape responses. The observed noise-induced sensitization was disrupted by AMPA receptor blockade using DNQX, but not NMDA receptor blockade. Together, these experiments suggest a complex effect of noise exposure on the neural circuits mediating auditory-evoked behaviors in larval zebrafish.

https://ift.tt/2NSJ1O1

Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals

Abstract

Bilateral cochlear implant (CI) users have poor perceptual sensitivity to interaural time differences (ITDs), which limits their ability to localize sounds and understand speech in noisy environments. This is especially true for high-rate (> 300 pps) periodic pulse trains, which are used as carriers in CI processors. Here, we investigate a novel stimulation strategy in which extra pulses are added to high-rate periodic pulse trains to introduce short inter-pulse intervals (SIPIs). We hypothesized that SIPIs can improve neural ITD sensitivity similarly to the effect observed by randomly jittering IPIs (Hancock et al., J. Neurophysiol. 108:714–28, 2012). To test this hypothesis, we measured ITD sensitivity of single units in the inferior colliculus (IC) of unanesthetized rabbits with bilateral CIs. Introducing SIPIs into high-rate pulse trains significantly increased firing rates for ~ 60 % of IC neurons, and the extra spikes tended to be synchronized to the SIPIs. The additional firings produced by SIPIs uncovered latent ITD sensitivity that was comparable to that observed with low-rate pulse trains. In some neurons, high spontaneous firing rates masked the ITD sensitivity introduced by SIPIs. ITD sensitivity in these neurons could be revealed by emphasizing stimulus-synchronized spikes with a coincidence detection analysis. Overall, these results with SIPIs are consistent with the effects observed previously with jittered pulse trains, with the added benefit of retaining control over the timing and number of SIPIs. A novel CI processing strategy could incorporate SIPIs by inserting them at selected times to high-rate pulse train carriers. Such a strategy could potentially improve ITD perception without degrading speech intelligibility and thereby improve outcomes for bilateral CI users.

https://ift.tt/2M0yX3G

The Stress Response in the Non-sensory Cells of the Cochlea Under Pathological Conditions—Possible Role in Mediating Noise Vulnerability

Abstract

Various stressors, such as loud sounds and the effects of aging, impair the function and viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological changes in the cochlear non-sensory cells as well. We have here studied the stress response mounted in the lateral wall of the cochlea during acute noise stress and during age-related chronic stress. We have used the activation of JNK/c-Jun, ERK, and NF-κB pathways as a readout of the stress response, and the expression of the FoxO3 transcription factor as a possible additional player in cellular stress. In the aging cochlea, NF-κB transcriptional activity was strongly induced in the stria vascularis of the lateral wall. This induction was linked with the atrophy of the stria vascularis, suggesting a role for NF-κB signaling in mediating age-related strial degeneration. Acutely following noise exposure, the JNK/c-Jun, ERK, and NF-κB pathways were activated in the spiral ligament of the lateral wall of CBA/Ca mice. This activation was concomitant with the morphological transformation of macrophages, suggesting that the upregulation of stress signaling leads to macrophage activation. In contrast, C57BL/6J mice lacked these responses. Only the combination of noise exposure and a systemic stressor, lipopolysaccharide, exceeded the threshold for the activation of stress signaling in the lateral wall of C57BL/6J mice. In addition, we found that, at the young adult age, outer hair cells of CBA/Ca mice are much more vulnerable to loud sounds compared to these cells of C57BL/6J mice. These results suggest that the differential stress response in the lateral wall of the two mouse strains underlies, in part, the differential noise vulnerability of their outer hair cells. Together, we propose that the molecular stress response in the lateral wall modulates the outcome of the stressed cochlea.

https://ift.tt/2wQcoKm

Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media

Abstract

The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. The AOM was established by transbullar injection of nontypeable Haemophilus influenzae. The TM surface vibration was measured in control (uninfected) animals and two AOM groups of animals: 4 days (4D) and 8 days (8D) post inoculation. To quantify the effect of middle ear pressure in those infected ears, the SLDV measurement was first conducted in unopened AOM ears and then in middle ear pressure released ears. Results showed that middle ear infection generally reduced the TM displacement across the entire surface, but the reduction in the umbo displacement over the time course, from 4 to 8 days post inoculation, was less than the reduction in the displacement at the center of each quadrant. The presence of middle ear fluid shifted the occurrence of traveling-wave-like motion on the TM surface to lower frequencies. The observation of the spatial variations of TM surface motion from this study will help refine our understanding of the middle ear sound transmission characteristics in relation to AOM.

https://ift.tt/2MToV9X

Does the King Airway system signal the end of intubation skills?

Our co-hosts tackle the topic of supraglottic airways, and the best way to approach them in the field

https://ift.tt/2Ma8roI

Sex Education | Age Appropriate Topics

Sex education is important for all children but knowing what topics to cover at each age is difficult for many parents. At what age should you tell your children about the birds and the bees? How much detail do they really need? Dr. Sarah Garwood provides some age appropriate topics to discuss with your children as they mature.

The post Sex Education | Age Appropriate Topics appeared first on ChildrensMD.

https://ift.tt/2wMVxYU

Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals

Abstract

Bilateral cochlear implant (CI) users have poor perceptual sensitivity to interaural time differences (ITDs), which limits their ability to localize sounds and understand speech in noisy environments. This is especially true for high-rate (> 300 pps) periodic pulse trains, which are used as carriers in CI processors. Here, we investigate a novel stimulation strategy in which extra pulses are added to high-rate periodic pulse trains to introduce short inter-pulse intervals (SIPIs). We hypothesized that SIPIs can improve neural ITD sensitivity similarly to the effect observed by randomly jittering IPIs (Hancock et al., J. Neurophysiol. 108:714–28, 2012). To test this hypothesis, we measured ITD sensitivity of single units in the inferior colliculus (IC) of unanesthetized rabbits with bilateral CIs. Introducing SIPIs into high-rate pulse trains significantly increased firing rates for ~ 60 % of IC neurons, and the extra spikes tended to be synchronized to the SIPIs. The additional firings produced by SIPIs uncovered latent ITD sensitivity that was comparable to that observed with low-rate pulse trains. In some neurons, high spontaneous firing rates masked the ITD sensitivity introduced by SIPIs. ITD sensitivity in these neurons could be revealed by emphasizing stimulus-synchronized spikes with a coincidence detection analysis. Overall, these results with SIPIs are consistent with the effects observed previously with jittered pulse trains, with the added benefit of retaining control over the timing and number of SIPIs. A novel CI processing strategy could incorporate SIPIs by inserting them at selected times to high-rate pulse train carriers. Such a strategy could potentially improve ITD perception without degrading speech intelligibility and thereby improve outcomes for bilateral CI users.

https://ift.tt/2M0yX3G

Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media

Abstract

The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. The AOM was established by transbullar injection of nontypeable Haemophilus influenzae. The TM surface vibration was measured in control (uninfected) animals and two AOM groups of animals: 4 days (4D) and 8 days (8D) post inoculation. To quantify the effect of middle ear pressure in those infected ears, the SLDV measurement was first conducted in unopened AOM ears and then in middle ear pressure released ears. Results showed that middle ear infection generally reduced the TM displacement across the entire surface, but the reduction in the umbo displacement over the time course, from 4 to 8 days post inoculation, was less than the reduction in the displacement at the center of each quadrant. The presence of middle ear fluid shifted the occurrence of traveling-wave-like motion on the TM surface to lower frequencies. The observation of the spatial variations of TM surface motion from this study will help refine our understanding of the middle ear sound transmission characteristics in relation to AOM.

https://ift.tt/2MToV9X

Inflammation cutanée de contiguïté : situations diverses et contours flous

Publication date: Available online 5 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): P. del Giudice

https://ift.tt/2NNVd2m

Comparison of Opioid Utilization Patterns After Major Head and Neck Procedures

This observational study compares postoperative use of opioids between the United States and Hong Kong in patients undergoing head and neck surgery.

https://ift.tt/2wOZHiO

Validation of Haptic Properties of Materials for Endoscopic Sinus and Skull Base Surgery Simulation—Reply

In Reply In their analysis of our study, Dr Favier and colleagues suggest improvements in methodology to focus on haptic feedback fidelity through mechanical testing. We appreciate this thoughtful commentary and agree that both subjective and quantifiable measures are needed to optimally evaluate surgical simulators. As seen in their study evaluating mechanical characteristics of 3-dimensionally (3D)-printed material for skull base procedures, certain 3D-printed materials may differ in mechanical forces compared with human cadaver bone. Further, cadaver bone may not realistically represent in vivo sinus lamellae. Accordingly, although objective measurements of mechanical force are ideal, the intended audience of the simulator must also participate in the evaluation to assist in determining realism of the haptic feedback. Although we acknowledge that study participants were mostly resident physicians, surgical trainees are frequently the intended audience for surgical simulation and should be included in the development of such simulators. One method for evaluating the qualifications of study participants would be to choose a set number of live surgical experiences and statistically evaluate whether surgical experience affects participant rating of haptic feedback. Unfortunately, given the small sample size in our study, meaningful conclusions would be difficult to draw with these limited data.

https://ift.tt/2CqpEdD

Validation of Haptic Properties of Materials for Endoscopic Sinus and Skull Base Surgery Simulation

To the Editor In the field of rhinology and skull base surgery, many 3-dimensionally (3D)-printed simulators have been described. In their study, Hsieh and colleagues consider a material, VeroWhite, for endoscopic sinus and skull base surgical model 3D-printing. The aim was to study the anatomical accuracy and haptic feedback of the model to validate its use for surgical learning. Its anatomical accuracy was scientifically determined, thanks to a double comparison: segmentation of real patient anatomy compared with segmentation of the 3D-printed model; image-guided navigation on the model using the patient's original computed tomographic (CT) findings, to assess the accuracy of 13 important surgical landmarks. The authors concluded that VeroWhite was suitable to print accurate anatomical 3D models of the skull base and sinuses.

https://ift.tt/2oLDDBa

Association of Cognition and Age-Related Hearing Impairment

This cohort study investigates the link between age-related hearing impairment and cognitive decline and explores untreated hearing loss and social isolation as potential explanations in a cohort of individuals 50 years or older from the United Kingdom.

https://ift.tt/2wO2Sql

Symptom Burden Associated With Late Lower Cranial Neuropathy in Long-term Oropharyngeal Cancer Survivors

This cross-sectional survey study of oropharyngeal cancer survivors investigates the association of late lower cranial neuropathy with severity of cancer treatment–related symptoms and general functional impairment.

https://ift.tt/2oJj8VM

Preoperative Imaging in Primary Hyperparathyroidism

This narrative review describes the advantages and disadvantages of current and emerging preoperative imaging technologies for primary hyperparathyroidism.

https://ift.tt/2Cptwvv

Invisible Empire of Hate: Gender Differences in the Ku Klux Klan's Online Justifications for Violence

Violence and Gender, Ahead of Print.


https://ift.tt/2wNYMhX

Regulatory T cell deficiency and autoimmune skin disease: beyond scurfy mouse and IPEX

Publication date: Available online 6 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Takashi Hashimoto, Hayato Takahashi, Shimon Sakaguchi

https://ift.tt/2NoWb8e

RhoA/ROCK Signaling Modulates Lineage Commitment of Mesenchymal Stem Cells in Asthma through Lef1

Publication date: Available online 5 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Xia Ke, Danh C. Do, Changjun Li, Yilin Zhao, Marian Kollarik, Qingling Fu, Mei Wan, Peisong Gao

ABSTRACT

Rationale

Mesenchymal stem cells (MSCs) are increased in the airways after allergen challenge. RhoA/ROCK signaling is critical in determining the lineage fate of MSCs in tissue repair/remodeling.

Objectives

To investigate the role of RhoA/ROCK signaling in lineage commitment of MSCs during allergen-induced airway remodeling and delineate the underlying mechanisms.

Methods

Active RhoA expression in asthmatic lung tissues and its role in cockroach allergen-induced airway inflammation and remodeling were investigated. The RhoA/ROCK signaling-mediated MSC lineage commitment was assessed in an asthma mouse model using MSC lineage tracing mice (nestin-Cre; ROSA26-EYFP). The role of RhoA/ROCK in MSC lineage commitment was also examined by MSCs expressing constitutively active RhoA (RhoA-L63) or dominant negative RhoA (RhoA-N19). Downstream RhoA-regulated genes were identified using the stem cell signaling array.

Results

Lung tissues from asthmatic mice showed increased expression of active RhoA when compared with those from controls. Inhibition of RhoA/ROCK signaling with fasudil, a RhoA/ROCK inhibitor, reversed established cockroach allergen-induced airway inflammation and remodeling as assessed by more collagen deposition/fibrosis. Furthermore, fasudil inhibited MSC differentiation into fibroblasts/myofibroblasts, but promoted MSC differentiation into epithelial cells in asthmatic nestin-Cre; ROSA26-EYFP mice. Consistently, expression of RhoA-L63 facilitated the differentiation of MSCs to fibroblasts/myofibroblasts, whereas expression of RhoA-19 switched the differentiation toward epithelial cells. Gene Array identified the Wnt signaling effector Lef1 as the most up-regulated gene in RhoA-L63-transfected MSCs. Knockdown of Lef1 induced MSC differentiation away from fibroblasts/myofibroblasts but towards epithelial cells.

Conclusions

These findings uncover a previously unrecognized role of RhoA/ROCK signaling in MSC-involved airway repair/remodeling in asthma.

https://ift.tt/2PGtMYM

Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency

Publication date: Available online 5 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Donald B. Kohn, Michael S. Hershfield, Jennifer M. Puck, Alessandro Aiuti, Annaliesse Blincoe, H. Bobby Gaspar, Luigi D. Notarangelo, Eyal Grunebaum

Abstract

Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined immunodeficiency (SCID), known as ADA-SCID. Most affected infants can be diagnosed while still asymptomatic by a SCID newborn screening test, allowing early initiation of therapy. We reviewed the evidence currently available and propose a consensus management strategy. In addition to the treatment of the immune deficiency of ADA-SCID, patients should be followed for specific non-infectious respiratory, neurological and biochemical complications associated with ADA deficiency. All patients should initially receive enzyme replacement therapy (ERT), followed by definitive treatment with either of two equal first line options. If an HLA matched sibling donor (MSD) or matched family donor (MFD) is available, allogeneic hematopoietic stem cell transplantation (HSCT) should be pursued. The excellent safety and efficacy observed in over 100 ADA-SCID patients who received gamma-retrovirus or lentivirus mediated autologous hematopoietic stem cell gene therapy (HSC-GT) since 2000 now positions HSC-GT as an equal alternative. If MSD/MFD HSCT or HSC-GT are not available or have failed, ERT can be continued or re-instituted, and HSCT using alternative donors should be considered. The outcomes of novel HSCT, ERT and HSC-GT strategies should be evaluated prospectively in "real life" conditions to further inform these management guidelines.

https://ift.tt/2MTPSdx

Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patients

Publication date: Available online 5 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Emma Guttman-Yassky, Robert Bissonnette, Benjamin Ungar, Mayte Suárez-Fariñas, Marius Ardeleanu, Hitokazu Esaki, Maria Suprun, Yeriel Estrada, Hui Xu, Xiangyu Peng, Jonathan I. Silverberg, Alan Menter, James G. Krueger, Rick Zhang, Usman Chaudhry, Brian Swanson, Neil M.H. Graham, Gianluca Pirozzi, George D. Yancopoulos, Jennifer D.D. Hamilton

ABSTRACT

Background

Dupilumab is an IL-4Rα monoclonal antibody inhibiting signaling of IL-4/IL-13, key drivers of Type 2-driven inflammation, as demonstrated by its efficacy in atopic/allergic diseases.

Objective

This placebo-controlled, double-blind trial (NCT01979016) evaluated efficacy, safety, and effects of dupilumab on molecular/cellular lesional and nonlesional skin phenotypes and systemic Type 2 biomarkers of moderate-to-severe atopic dermatitis (AD) patients.

Methods

Skin biopsies and blood were evaluated from 54 patients randomized 1:1 to weekly subcutaneous 200 mg dupilumab or placebo for 16 weeks.

Results

Dupilumab (versus placebo) significantly improved AD clinical signs and symptoms, was well tolerated, and progressively shifted the lesional transcriptome toward a nonlesional phenotype (weeks 4–16). Mean improvements in a meta-analysis-derived AD transcriptome (genes differentially expressed between lesional and nonlesional skin) were 68.8% and 110.8% with dupilumab and −10.5% and 55.0% with placebo (weeks 4 and 16, respectively; P<0.001). Dupilumab significantly reduced expression of genes involved in Type 2 inflammation (IL-13/IL-31/CCL17/CCL18/CCL26), epidermal hyperplasia (K16/MKi67), T-cells, dendritic cells (ICOS/CD11c/CTLA4), and Th17/Th22 activity (IL-17A/IL-22/S100As) and concurrently increased expression of epidermal differentiation, barrier, and lipid-metabolism genes (FLG/LOR/claudins/ELOVL3). Dupilumab reduced lesional epidermal thickness versus placebo (week 4, P=0.001; week 16, P=0.0002). Improvements in clinical and histological measures correlated significantly with modulation of gene expression. Dupilumab also significantly suppressed Type 2 serum biomarkers, including CCL17, CCL18, periostin, and total and allergen-specific IgEs.

Conclusion

Dupilumab-mediated inhibition of IL-4/IL-13 signaling via IL-4Rα blockade significantly and progressively improved disease activity, suppressed cellular/molecular cutaneous markers of inflammation and systemic measures of Type 2 inflammation, and reversed AD-associated epidermal abnormalities.

https://ift.tt/2PIpu34

Paraben exposures and asthma-related outcomes among children from the U.S. general population

Publication date: Available online 5 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Lesliam Quirós-Alcalá, Nadia N. Hansel, Meredith C. McCormack, Elizabeth C. Matsui

ABSTRACT

Background

Parabens are synthetic preservatives present in many consumer products. Their antimicrobial and endocrine disrupting properties have raised concerns that they may play a role in respiratory and allergic diseases; however, studies exploring these associations are scarce.

Objective

We examined the cross-sectional association between parabens and asthma morbidity among 450 children with asthma and with asthma prevalence among 4,023 children in the U.S. general population, participating in the National Health and Nutrition Examination Survey (2005-2014).

Methods

We conducted multivariable logistic regression to examine associations between urinary paraben biomarker concentrations (butyl-BP, ethyl-EP, methyl-MP, and propyl-PP) and asthma attacks and emergency department (ED) visits among children with asthma, and with current asthma diagnosis among all children. We also examined heterogeneity of associations by sex.

Results

We observed an increased prevalence odds of reporting ED visits for every 10-fold increase in MP and PP concentrations among boys with asthma (adjusted prevalence odds ratio, aPOR:2.61, 95% confidence interval, CI:1.40, 4.85 and aPOR:2.18, 95%CI:1.22, 3.89, respectively; p_{interaction-MP}=0.002; p_{interaction-PP}=0.003); associations remained after adjusting for other phenolic compounds previously linked to respiratory outcomes. No other dimorphic effects of exposure by sex were observed. Among children in the general population, no overall associations with current asthma were observed, although there was a positive trend with PP and current asthma diagnosis.

Conclusion

We identified differential effects of exposure to select parabens by sex on asthma morbidity. Further studies are needed to replicate these findings, and elucidate mechanisms by which parabens could impact respiratory health and elicit dimorphic effects by sex.

https://ift.tt/2MTPMmb

Acute respiratory infections in early childhood and risk of asthma at 7 years of age

Publication date: Available online 5 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Laura Toivonen, Ville Forsström, Matti Waris, Ville Peltola

https://ift.tt/2PK90aN

Midostaurin in patients with indolent systemic mastocytosis: An open-label phase 2 trial

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Bjorn van Anrooij, Joanne N.G. Oude Elberink, Lambert F.R. Span, Jan G.R. de Monchy, Stefano Rosati, André B. Mulder, Johanna C. Kluin-Nelemans

https://ift.tt/2MP8fQN

Insulin decreases expression of the proinflammatory receptor proteinase-activated receptor-2 on human airway epithelial cells

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Vivek D. Gandhi, Nami Shrestha Palikhe, Shereen M. Hamza, Jason R.B. Dyck, Jean Buteau, Harissios Vliagoftis

https://ift.tt/2NPl2ip

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population-based cohort study

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Jung Min Bae, Hyuck Sun Kwon, Gyong Moon Kim, Kyung-Su Park, Ki-Jo Kim

https://ift.tt/2MP1j6h

Deconstructive somatic cell nuclear transfer reveals novel regulatory T-cell subsets

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Manching Ku, Eugene Ke, Mohsen Sabouri-Ghomi, Justin R. Abadejos, Brent Freeman, Amy Nham, Nathaniel Phillips, Kevin Y. Yang, Kathy O. Lui, Oktay Kirak

https://ift.tt/2PK8WI5

Aspergillosis, eosinophilic esophagitis, and allergic rhinitis in signal transducer and activator of transcription 3 haploinsufficiency

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Mukil Natarajan, Amy P. Hsu, Michael A. Weinreich, Yuan Zhang, Julie E. Niemela, John A. Butman, Stefania Pittaluga, Janyce Sugui, Amanda L. Collar, Jean K. Lim, Tirdad Zangeneh, Tara Carr, Andrew J. Oler, Morgan Similuk, Lindsey B. Rosen, Jigar V. Desai, Alexandra F. Freeman, Steven M. Holland, Kyung J. Kwon-Chung, Joshua D. Milner

https://ift.tt/2MTzFVM

Association of ST2 polymorphisms with atopy, asthma, and leukemia

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Melissa H. Bloodworth, Mark Rusznak, Lisa Bastarache, Janey Wang, Joshua C. Denny, R. Stokes Peebles

https://ift.tt/2PK2fps

Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Anna Berekméri, Anne Latzko, Adewonuola Alase, Tom Macleod, Joseph S. Ainscough, Philip Laws, Mark Goodfield, Andrew Wright, Philip Helliwell, Sara Edward, Gordon D. Brown, Delyth M. Reid, Joerg Wenzel, Martin Stacey, Miriam Wittmann

https://ift.tt/2MUtCA0

Context matters: TH2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Lorenz Aglas, Stefanie Gilles, Renate Bauer, Sara Huber, Galber R. Araujo, Geoffrey Mueller, Sandra Scheiblhofer, Marie Amisi, Hieu-Hoa Dang, Peter Briza, Barbara Bohle, Jutta Horejs-Hoeck, Claudia Traidl-Hoffmann, Fatima Ferreira

https://ift.tt/2PHshtn

Micro RNAs are required for Langerhans cell, skin- and lung-resident macrophage ontogeny

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Yi Yao, Carly Martin, Congcong Yin, Chunyuan Guo, Zheng Dong, Li Zhou, Qing-Sheng Mi

https://ift.tt/2MRlYXf

AllergoOncology: Generating a canine anticancer IgE against the epidermal growth factor receptor

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Judit Fazekas-Singer, Josef Singer, Kristina M. Ilieva, Miroslawa Matz, Ina Herrmann, Edzard Spillner, Sophia N. Karagiannis, Erika Jensen-Jarolim

https://ift.tt/2PK8Joh

Reference values for peripheral blood lymphocyte subsets of healthy children in China

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Yuan Ding, Lina Zhou, Yu Xia, Wei Wang, Ying Wang, Li Li, Zhongxiang Qi, Linqing Zhong, Jinqiao Sun, Wenjing Tang, Fangfang Liang, Haijuan Xiao, Tao Qin, Ying Luo, Xuezhen Zhao, Zhou Shu, Ying Ru, Rongxin Dai, Hong Wang, Yanping Wang

https://ift.tt/2NnpE2j

Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Chloé Michaudel, Claire Mackowiak, Isabelle Maillet, Louis Fauconnier, Cezmi A. Akdis, Milena Sokolowska, Anita Dreher, Hern-Tze Tina Tan, Valérie F. Quesniaux, Bernhard Ryffel, Dieudonnée Togbe

Background

IL-33 plays a critical role in regulation of tissue homeostasis, injury, and repair. Whether IL-33 regulates neutrophil recruitment and functions independently of airways hyperresponsiveness (AHR) in the setting of ozone-induced lung injury and inflammation is unclear.

Objective

We sought to examine the role of the IL-33/ST2 axis in lung inflammation on acute ozone exposure in mice.

Methods

ST2- and Il33–deficient, IL-33 citrine reporter, and C57BL/6 (wild-type) mice underwent a single ozone exposure (1 ppm for 1 hour) in all studies. Cell recruitment in lung tissue and the bronchoalveolar space, inflammatory parameters, epithelial barrier damage, and airway hyperresponsiveness (AHR) were determined.

Results

We report that a single ozone exposure causes rapid disruption of the epithelial barrier within 1 hour, followed by a second phase of respiratory barrier injury with increased neutrophil recruitment, reactive oxygen species production, AHR, and IL-33 expression in epithelial and myeloid cells in wild-type mice. In the absence of IL-33 or IL-33 receptor/ST2, epithelial cell injury with protein leak and myeloid cell recruitment and inflammation are further increased, whereas the tight junction proteins E-cadherin and zonula occludens 1 and reactive oxygen species expression in neutrophils and AHR are diminished. ST2 neutralization recapitulated the enhanced ozone-induced neutrophilic inflammation. However, myeloid cell depletion using GR-1 antibody reduced ozone-induced lung inflammation, epithelial cell injury, and protein leak, whereas administration of recombinant mouse IL-33 reduced neutrophil recruitment in Il33–deficient mice.

Conclusion

Data demonstrate that ozone causes an immediate barrier injury that precedes myeloid cell–mediated inflammatory injury under the control of the IL-33/ST2 axis. Thus IL-33/ST2 signaling is critical for maintenance of intact epithelial barrier and inflammation.

Graphical abstract

https://ift.tt/2NTJSOk

Efficacy of lentivirus-mediated gene therapy in an Omenn syndrome recombination-activating gene 2 mouse model is not hindered by inflammation and immune dysregulation

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Valentina Capo, Maria Carmina Castiello, Elena Fontana, Sara Penna, Marita Bosticardo, Elena Draghici, Luigi P. Poliani, Lucia Sergi Sergi, Rosita Rigoni, Barbara Cassani, Monica Zanussi, Paola Carrera, Paolo Uva, Kerry Dobbs, Nicolò Sacchetti, Luigi D. Notarangelo, Niek P. van Til, Gerard Wagemaker, Anna Villa

Background

Omenn syndrome (OS) is a rare severe combined immunodeficiency associated with autoimmunity and caused by defects in lymphoid-specific V(D)J recombination. Most patients carry hypomorphic mutations in recombination-activating gene (RAG) 1 or 2. Hematopoietic stem cell transplantation is the standard treatment; however, gene therapy (GT) might represent a valid alternative, especially for patients lacking a matched donor.

Objective

We sought to determine the efficacy of lentiviral vector (LV)–mediated GT in the murine model of OS (Rag2^R229Q/R229Q) in correcting immunodeficiency and autoimmunity.

Methods

Lineage-negative cells from mice with OS were transduced with an LV encoding the human RAG2 gene and injected into irradiated recipients with OS. Control mice underwent transplantation with wild-type or OS-untransduced lineage-negative cells. Immunophenotyping, T-dependent and T-independent antigen challenge, immune spectratyping, autoantibody detection, and detailed tissue immunohistochemical analyses were performed.

Results

LV-mediated GT allowed immunologic reconstitution, although it was suboptimal compared with that seen in wild-type bone marrow (BM)−transplanted OS mice in peripheral blood and hematopoietic organs, such as the BM, thymus, and spleen. We observed in vivo variability in the efficacy of GT correlating with the levels of transduction achieved. Immunoglobulin levels and T-cell repertoire normalized, and gene-corrected mice responded properly to challenges in vivo. Autoimmune manifestations, such as skin infiltration and autoantibodies, dramatically improved in GT mice with a vector copy number/genome higher than 1 in the BM and 2 in the thymus.

Conclusions

Our data show that LV-mediated GT for patients with OS significantly ameliorates the immunodeficiency, even in an inflammatory environment.

https://ift.tt/2NnpCHJ

An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome

Publication date: September 2018

Source: Journal of Allergy and Clinical Immunology, Volume 142, Issue 3

Author(s): Aleksandra Gil-Krzewska, Mezida B. Saeed, Anna Oszmiana, Elizabeth R. Fischer, Kathryn Lagrue, William A. Gahl, Wendy J. Introne, John E. Coligan, Daniel M. Davis, Konrad Krzewski

Background

Chediak-Higashi syndrome (CHS) is a rare disorder caused by biallelic mutations in the lysosomal trafficking regulator gene (LYST), resulting in formation of giant lysosomes or lysosome-related organelles in several cell types. The disease is characterized by immunodeficiency and a fatal hemophagocytic lymphohistiocytosis caused by impaired function of cytotoxic lymphocytes, including natural killer (NK) cells.

Objective

We sought to determine the underlying biochemical cause of the impaired cytotoxicity of NK cells in patients with CHS.

Methods

We generated a human cell model of CHS using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. We used a combination of classical techniques to evaluate lysosomal function and cell activity in the model system and super-resolution microscopy to visualize F-actin and lytic granules in normal and LYST-deficient NK cells.

Results

Loss of LYST function in a human NK cell line, NK92mi, resulted in inhibition of NK cell cytotoxicity and reproduced other aspects of the CHS cellular phenotype, including the presence of significantly enlarged lytic granules with defective exocytosis and impaired integrity of endolysosomal compartments. The large granules had an acidic pH and normal activity of lysosomal enzymes and were positive for the proteins essential for lytic granule exocytosis. Visualization of the actin meshwork openings at the immunologic synapse revealed that the cortical actin acts as a barrier for secretion of such large granules at the cell-cell contact site. Decreasing the cortical actin density at the immunologic synapse or decreasing the lytic granule size restored the ability of LYST-deficient NK cells to degranulate and kill target cells.

Conclusion

The cortical actin and granule size play significant roles in NK cell cytotoxic function. We present evidence that the periodicity of subsynaptic actin is an important factor limiting the release of large lytic granules from NK cells from patients with CHS and could be a novel target for pharmaceutical intervention.

https://ift.tt/2NSvpCm

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Abstract

Background

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16^INK4, pRB, cyclin D1 and p53. The objective of this study was to assess cell cycle proteins as potential surrogate markers for HR-HPV DNA testing to identify OPSCC with favorable prognosis after resection.

Methods

Tissue microarray cores of 313 surgically treated OPSCC were stained for p16^INK4a, pRB, cyclin D1 and p53 using immunohistochemistry. Protein expression was scored as high or low based on the proportion of positive carcinoma cells. Tumor samples were analysed for HR-HPV DNA with polymerase chain reaction-based testing. Associations between cell cycle protein expression and HR-HPV DNA status were evaluated by calculating sensitivity, specificity, predictive values, and diagnostic odds ratios (DOR). Kaplan-Meier and Cox regression analysis were applied to evaluate associations between cell cycle protein expression and patient outcome.

Results

High expression of p16^INK4a, cyclin D1, pRB and p53 in tumor cells were observed in 51.8%, 51.4%, 41.9% and 33.5% of OPSCC, respectively. HR-HPV DNA positive were 158/313 (50.5%) tumor samples (HPV16: 147, HPV18: 1, HPV33: 5, HPV35: 2, HPV56: 2, and HPV59: 1). P16^INK4a showed a higher DOR to predict HR-HPV DNA positivity than pRB, cyclin D1 and p53. Both the p16^INK4a/pRB and the p16^INK4a/pRB/cyclin D1/p53 signatures had lower DOR than p16^INK4a alone. Improved 5-year overall and disease-specific survival were associated with HR-HPV DNA positivity, high p16^INK4a, low pRB, low cyclin D1, and low p53 expression. Associations with improved outcome were also observed for the marker combinations high p16^INK4a/positive HR-HPV DNA, high p16^INK4a/low pRB and high p16^INK4a/low pRB/low cyclin D1/low p53. In a multivariate analysis adjusted for age, smoking history, pT and pN category, high p16^INK4a expression showed the lowest hazard ratio for death.

Conclusions

High p16^INK4a expression is a reliable marker for survival prognostication in surgically treated OPSCC patients. Protein signatures including the pRB, cyclin D1 and p53 proteins do not further increase the prognostic performance of p16^INK4a as a single marker.

https://ift.tt/2NTEn2j

Sequential Eruptions Triggered by Flux Emergence: Observations and Modeling

Dacie, S; Torok, T; Demoulin, P; Linton, MG; Downs, C; van Driel-Gesztelyi, L; Long, DM; Dacie, S; Torok, T; Demoulin, P; Linton, MG; Downs, C; van Driel-Gesztelyi, L; Long, DM; Leake, JE; - view fewer (2018) Sequential Eruptions Triggered by Flux Emergence: Observations and Modeling. The Astrophysical Journal , 862 (2) , Article 117. 10.3847/1538-4357/aacce3 . Green open access

https://ift.tt/2wR3QTg

Myocardial extracellular volume quantified by magnetic resonance is increased in cirrhosis and related to poor outcome.

Wiese, S; Hove, J; Mo, S; Mookerjee, RP; Petersen, CL; Vester-Andersen, MK; Mygind, ND; ... Møller, S; + view all Wiese, S; Hove, J; Mo, S; Mookerjee, RP; Petersen, CL; Vester-Andersen, MK; Mygind, ND; Goetze, JP; Kjaer, A; Bendtsen, F; Møller, S; - view fewer (2018) Myocardial extracellular volume quantified by magnetic resonance is increased in cirrhosis and related to poor outcome. Liver International , 38 (9) pp. 1614-1623. 10.1111/liv.13870 .

https://ift.tt/2wLWyiN

Managing intrinsic motivation in a long-run relationship

Eliaz, K; Spiegler, R; (2018) Managing intrinsic motivation in a long-run relationship. Economics Letters , 165 pp. 6-9. 10.1016/j.econlet.2018.01.018 .

https://ift.tt/2oMvwV6

Stellar Streams Discovered in the Dark Energy Survey

Shipp, N; Drlica-Wagner, A; Balbinot, E; Ferguson, P; Erkal, D; Li, TS; Bechtol, K; ... Wechsler, RH; + view all Shipp, N; Drlica-Wagner, A; Balbinot, E; Ferguson, P; Erkal, D; Li, TS; Bechtol, K; Belokurov, V; Buncher, B; Carollo, D; Kind, MC; Kuehn, K; Marshall, JL; Pace, AB; Rykoff, ES; Sevilla-Noarbe, I; Sheldon, E; Strigari, L; Vivas, AK; Yanny, B; Zenteno, A; Abbott, TMC; Abdalla, FB; Allam, S; Avila, S; Bertin, E; Brooks, D; Burke, DL; Carretero, J; Castander, FJ; Cawthon, R; Crocce, M; Cunha, CE; D'Andrea, CB; da Costa, LN; Davis, C; De Vicente, J; Desai, S; Diehl, HT; Doel, P; Evrard, AE; Flaugher, B; Fosalba, P; Frieman, J; Garcia-Bellido, J; Gaztanaga, E; Gerdes, DW; Gruen, D; Gruendl, RA; Gschwend, J; Gutierrez, G; Hartley, W; Honscheid, K; Hoyle, B; James, DJ; Johnson, MD; Krause, E; Kuropatkin, N; Lahav, O; Lin, H; Maia, MAG; March, M; Martini, P; Menanteau, F; Miller, CJ; Miquel, R; Nichol, RC; Plazas, AA; Romer, AK; Sako, M; Sanchez, E; Santiago, B; Scarpine, V; Schindler, R; Schubnell, M; Smith, M; Smith, RC; Sobreira, F; Suchyta, E; Swanson, MEC; Tarle, G; Thomas, D; Tucker, DL; Walker, AR; Wechsler, RH; - view fewer (2018) Stellar Streams Discovered in the Dark Energy Survey. The Astrophysical Journal , 862 (2) , Article 114. 10.3847/1538-4357/aacdab . Green open access

https://ift.tt/2wQAq6W

Buridanic competition

Bachi, B; Spiegler, R; (2017) Buridanic competition. Games and Economic Behavior , 107 pp. 298-315. 10.1016/j.geb.2017.10.024 .

https://ift.tt/2oMaiqe

The Chemistry of Phosphorus-bearing Molecules under Energetic Phenomena

Jimenez-Serra, I; Viti, S; Quenard, D; Holdship, J; (2018) The Chemistry of Phosphorus-bearing Molecules under Energetic Phenomena. The Astrophysical Journal , 862 (2) , Article 128. 10.3847/1538-4357/aacdf2 . Green open access

https://ift.tt/2Cs1Kys

Spillover Effects of Mass Layoffs

Schoenberg, U; Helm, I; Gathmann, C; (2018) Spillover Effects of Mass Layoffs. Journal of the European Economic Association (In press).

https://ift.tt/2oMRNlK

First Data Release of the COSMOS Ly alpha Mapping and Tomography Observations: 3D Ly alpha Forest Tomography at 2.05 < z < 2.55

Lee, K-G; Krolewski, A; White, M; Schlegel, D; Nugent, PE; Hennawi, JF; Muller, T; ... Tran, K-VH; + view all Lee, K-G; Krolewski, A; White, M; Schlegel, D; Nugent, PE; Hennawi, JF; Muller, T; Pan, R; Prochaska, JX; Font-Ribera, A; Suzuki, N; Glazebrook, K; Kacprzak, GG; Kartaltepe, JS; Koekemoer, AM; Le Fevre, O; Lemaux, BC; Maier, C; Nanayakkara, T; Rich, RM; Sanders, DB; Salvato, M; Tasca, L; Tran, K-VH; - view fewer (2018) First Data Release of the COSMOS Ly alpha Mapping and Tomography Observations: 3D Ly alpha Forest Tomography at 2.05 . Green open access

https://ift.tt/2wIpo3I

Behavioral Economics and the Atheoretical Style

Spiegler, R; (2019) Behavioral Economics and the Atheoretical Style. American Economic Journal: Microeconomics (In press). Green open access

https://ift.tt/2oMRqYo

The Progression of the Stargardt Disease Type 4 (ProgStar-4) Study: Design and Baseline Characteristics (ProgStar-4 Report No. 1)

Strauss, RW; Muñoz, B; Ahmed, MI; Bittencourt, M; Schönbach, EM; Michaelides, M; Birch, D; ... for the ProgStar-4 Study Group, ; + view all Strauss, RW; Muñoz, B; Ahmed, MI; Bittencourt, M; Schönbach, EM; Michaelides, M; Birch, D; Zrenner, E; Ervin, A-M; Charbel Issa, P; Kong, J; Wolfson, Y; Shah, M; Bagheri, S; West, S; Scholl, HPN; for the ProgStar-4 Study Group, ; - view fewer (2018) The Progression of the Stargardt Disease Type 4 (ProgStar-4) Study: Design and Baseline Characteristics (ProgStar-4 Report No. 1). Ophthalmic Research 10.1159/000491791 . (In press).

https://ift.tt/2wIpcS2

Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in root s=13 TeV pp collisions with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; ... Zwalinski, L; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Akesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; AlconadaVerzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; AlvarezGonzalez, B; AlvarezPiqueras, D; Alviggi, MG; Amadio, BT; AmaralCoutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor DosSantos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; 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Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bianchi, RM; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, NV; Biglietti, M; Billoud, TRV; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, DM; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blumenschein, U; Blunier, D; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Bock, C; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Bonilla, JSB; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; BossioSola, JD; Boudreau, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bozson, AJ; Bracinik, J; Brahimi, N; Brandt, A; Brandt, G; Brandt, O; Braren, F; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Brickwedde, B; Briglin, DL; Bristow, TM; Britton, D; Britzger, D; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brost, E; Broughton, JH; deRenstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, F; Bugge, MK; Bulekov, O; Bullock, D; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Buescher, D; Buescher, V; Buschmann, E; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabras, G; CabreraUrban, S; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; CalventeLopez, S; Calvet, D; Calvet, S; Calvet, TP; Calvetti, M; CamachoToro, R; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; CanoBret, M; Cantero, J; Cao, T; Cao, Y; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Casadei, D; Casado, MP; Casha, AF; Casolino, M; Casper, DW; Castelijn, R; CastilloGimenez, V; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; CerdaAlberich, L; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, DC; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, H; Chen, J; Chen, S; Chen, SJ; Chen, X; Chen, Y; Chen, Y-H; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; ElMoursli, RC; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, I; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Cinca, D; Cindro, V; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Clark, A; Clark, MR; Clark, PJ; Clarke, RN; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Coimbra, AEC; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Conde Muino, P; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corrigan, EE; Corriveau, F; Cortes-Gonzalez, A; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Crane, J; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; CuhadarDonszelmann, T; Cukierman, AR; Curatolo, M; Cuth, J; Czekierda, S; Czodrowski, P; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dahbi, S; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; D'amen, G; Dandoy, JR; Daneri, MF; Dang, NP; Dann, ND; Danninger, M; Dao, V; Darbo, G; Darmora, S; Dartsi, O; Dattagupta, A; Daubney, T; D'Auria, S; Davey, W; David, C; Davidek, T; Davis, DR; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Debenedetti, C; Dedovich, DV; Dehghanian, N; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Della Pietra, M; della Volpe, D; Dell'Acqua, A; Dell'Asta, L; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Denisov, SP; Denysiuk, D; D'Eramo, L; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; 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Enari, Y; Ennis, JS; Epland, MB; Erdmann, J; Ereditato, A; Errede, S; Escalier, M; Escobar, C; Esposito, B; EstradaPastor, O; Etienvre, AI; Etzion, E; Evans, H; Ezhilov, A; Ezzi, M; Fabbri, F; Fabbri, L; Fabiani, V; Facini, G; Faisca Rodrigues Pereira, RM; Fakhrutdinov, RM; Falciano, S; Falke, PJ; Falke, S; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feickert, M; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, M; Fenton, MJ; Fenyuk, AB; Feremenga, L; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filthaut, F; Fincke-Keeler, M; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, C; Fischer, J; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Flores, LM; Castillo, LRF; Fomin, N; Forcolin, GT; 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Heim, S; Heim, T; Heinemann, B; Heinrich, JJ; Heinrich, L; Heinz, C; Hejbal, J; Helary, L; Held, A; Hellesund, S; Hellman, S; Helsens, C; Henderson, RCW; Heng, Y; Henkelmann, S; HenriquesCorreia, AM; Herbert, GH; Herde, H; Herget, V; HernandezJimenez, Y; Herr, H; Herten, G; Hertenberger, R; Hervas, L; Herwig, TC; Hesketh, GG; Hessey, NP; Hetherly, JW; Higashino, S; Higon-Rodriguez, E; Hildebrand, K; Hill, E; Hill, JC; Hiller, KH; Hillier, SJ; Hils, M; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hlaluku, DR; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, MC; Hoecker, A; Hoeferkamp, MR; Hoenig, F; Hohn, D; Hohov, D; Holmes, TR; Holzbock, M; Homann, M; Honda, S; Honda, T; Hong, TM; Hoenle, A; Hooberman, BH; Hopkins, WH; Horii, Y; Horn, P; Horton, AJ; Horyn, LA; Hostachy, J-Y; Hostiuc, A; Hou, S; Hoummada, A; Howarth, J; Hoya, J; Hrabovsky, M; Hrdinka, J; Hristova, I; Hrivnac, J; Hrynevich, A; Hryn'ova, T; Hsu, PJ; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huebner, M; 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Measurements of b-jet tagging efficiency with the ATLAS detector using tt¯ events at √s=13 TeV

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Arabidze, G; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aperio Bella, L; Arabidze, G; - view fewer (2018) Measurements of b-jet tagging efficiency with the ATLAS detector using tt¯ events at √s=13 TeV. Journal of High Energy Physics , 2018 (8) , Article 089. 10.1007/JHEP08(2018)089 . Green open access

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Antinuclear Antibody‐Negative Systemic Lupus Erythematosus in an International Inception Cohort

Choi, MY; Clarke, AE; St Pierre, Y; Hanly, JG; Urowitz, MB; Romero-Diaz, J; Gordon, C; ... Fritzler, MJ; + view all Choi, MY; Clarke, AE; St Pierre, Y; Hanly, JG; Urowitz, MB; Romero-Diaz, J; Gordon, C; Bae, S-C; Bernatsky, S; Wallace, DJ; Merrill, JT; Isenberg, DA; Rahman, A; Ginzler, EM; Petri, M; Bruce, IN; Dooley, MA; Fortin, PR; Gladman, DD; Sanchez-Guerrero, J; Steinsson, K; Ramsey-Goldman, R; Khamashta, MA; Aranow, C; Alarcón, GS; Manzi, S; Nived, O; Zoma, AA; van Vollenhoven, RF; Ramos-Casals, M; Ruiz-Irastorza, G; Lim, SS; Kalunian, KC; Inanc, M; Kamen, DL; Peschken, CA; Jacobsen, S; Askanase, A; Stoll, T; Buyon, J; Mahler, M; Fritzler, MJ; - view fewer (2018) Antinuclear Antibody‐Negative Systemic Lupus Erythematosus in an International Inception Cohort. Arthritis Care & Research 10.1002/acr.23712 . (In press).

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Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort

Pelchen-Matthews, A; Ryom, L; Borges, ÁH; Edwards, S; Duvivier, C; Stephan, C; Sambatakou, H; ... EuroSIDA study, ; + view all Pelchen-Matthews, A; Ryom, L; Borges, ÁH; Edwards, S; Duvivier, C; Stephan, C; Sambatakou, H; Maciejewska, K; Portu, JJ; Weber, J; Degen, O; Calmy, A; Reikvam, DH; Jevtovic, D; Wiese, L; Smidt, J; Smiatacz, T; Hassoun, G; Kuznetsova, A; Clotet, B; Lundgren, J; Mocroft, A; EuroSIDA study, ; - view fewer (2018) Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort. AIDS 10.1097/QAD.0000000000001967 . (In press).

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SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups

Baruteau, A-E; Kyndt, F; Behr, ER; Vink, AS; Lachaud, M; Joong, A; Schott, J-J; ... Probst, V; + view all Baruteau, A-E; Kyndt, F; Behr, ER; Vink, AS; Lachaud, M; Joong, A; Schott, J-J; Horie, M; Denjoy, I; Crotti, L; Shimizu, W; Bos, JM; Stephenson, EA; Wong, L; Abrams, DJ; Davis, AM; Winbo, A; Dubin, AM; Sanatani, S; Liberman, L; Kaski, JP; Rudic, B; Kwok, SY; Rieubland, C; Tfelt-Hansen, J; Van Hare, GF; Guyomarc'h-Delasalle, B; Blom, NA; Wijeyeratne, YD; Gourraud, J-B; Le Marec, H; Ozawa, J; Fressart, V; Lupoglazoff, J-M; Dagradi, F; Spazzolini, C; Aiba, T; Tester, DJ; Zahavich, LA; Beauséjour-Ladouceur, V; Jadhav, M; Skinner, JR; Franciosi, S; Krahn, AD; Abdelsayed, M; Ruben, PC; Yung, T-C; Ackerman, MJ; Wilde, AA; Schwartz, PJ; Probst, V; - view fewer (2018) SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. European Heart Journal , 39 (31) pp. 2879-2887. 10.1093/eurheartj/ehy412 .

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Socio-economic variations in anticipated adverse reactions to testing HPV positive: Implications for the introduction of primary HPV-based cervical screening

O'Connor, M; O'Leary, E; Waller, J; Gallagher, P; Martin, CM; O'Leary, JJ; Sharp, L; O'Connor, M; O'Leary, E; Waller, J; Gallagher, P; Martin, CM; O'Leary, JJ; Sharp, L; Irish Cervical Screening Research Consortium (CERVIVA), ; - view fewer (2018) Socio-economic variations in anticipated adverse reactions to testing HPV positive: Implications for the introduction of primary HPV-based cervical screening. Preventive Medicine , 115 pp. 90-96. 10.1016/j.ypmed.2018.08.017 . (In press).

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Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa

Majonga, ED; Rehman, AM; McHugh, G; Mujuru, HA; Nathoo, K; Patel, MS; Munyati, S; ... Ferrand, RA; + view all Majonga, ED; Rehman, AM; McHugh, G; Mujuru, HA; Nathoo, K; Patel, MS; Munyati, S; Odland, JO; Kranzer, K; Kaski, JP; Ferrand, RA; - view fewer (2017) Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa. International Journal of Cardiology , 248 pp. 409-413. 10.1016/j.ijcard.2017.06.109 . Green open access

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