Editorial Board

Publication date: July 2018
Source:Clinical Immunology, Volume 192





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Radiological Study of the Ethmoidal Arteries in the Nasal Cavity and Its Pertinence to the Endoscopic Surgeon

Abstract

We studied the ethmoidal arteries using preexisting computer tomography of the paranasal sinuses (CT PNS) and statistically scrutinized data obtained between genders. A descriptive study from 77 CT PNS dated January 2016–December 2016 were collected and reviewed by two radiologists. A total of 54 (108 sides) CT PNS were studied of patients aged 18–77 years. 37 are male, 17 are female; with Bumiputera Sarawak predominance of 25 patients, 12 Malays, 16 Chinese and one Indian. Rate of identification are as follows: anterior ethmoidal artery (AEA)-100%, middle ethmoidal artery (MEA)-30%, posterior ethmoidal artery (PEA)-86%. The average distance from AEA–MEA is 8.1 ± 1.52 mm, MEA–PEA is 5.5 ± 1.29 mm and AEA–PEA is 12.9 ± 1.27 mm. The mean distance from PEA-the anterior wall of sphenoid is 7.7 ± 3.96 mm, and PEA-optic canal is 8.5 ± 3.1 mm with no statistical difference when compared between gender. AEA frequently presented with a long mesentery 57.4%, while 87.1% of PEA was hidden in a bony canal. The vertical distance of the AEA-skull base ranges from 0 to 12.5 mm whilst PEA-skull base is 0–4.7 mm. There is no statistical difference in distances of AEA, MEA nor PEA to skull base when analyzed between genders; t(82) = 1.663, p > 0.05, t(32) = 0.403, p > 0.05 and t(75) = 1.333, p > 0.05 respectively. We newly discovered, that 50% of MEA is hidden in a bony canal, and its distance to skull base ranged 0–5.3 mm. MEA and PEA less commonly have a short or long mesentery. Knowledge on the ethmoidal arteries especially in our unstudied population of diverse ethnicity, gains to assist surgeons worldwide, when embarking in endoscopic transnasal surgeries.

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Contact dermatitis with concomitant contact urticaria syndrome due to multiple ingredients of oxidative hair dye

Publication date: Available online 1 June 2018
Source:Allergology International
Author(s): Jun-ichi Iwata, Naoko Inomata, Megumi Sato, Mami Miyakawa, Toshiko Kawaguchi, Michiko Aihara




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The molecular allergology of subtropical grass pollen

Publication date: Available online 31 May 2018
Source:Molecular Immunology
Author(s): Thina Kailaivasan, Janet M. Davies
Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate climate zones. However, climate changes are altering the biogeographical distribution as well as timing and allergenicity of grass pollens. This provides an impetus for better understanding of the contribution of subtropical subfamilies of grasses to pollen allergy globally. Pollen of Chloridoideae (e.g. Cynodon dactylon; Bermuda grass) and Panicoideae (e.g. Paspalum notatum; Bahia grass or Sorghum halepense; Johnson grass) subfamilies are clinically important in subtropical zones of Australia, Asia, India, Africa, and America. These grasses differ ecologically and phylogenetically from temperate grasses and, importantly their allergen composition is qualitatively different. For example, subtropical grass pollens appear to lack the major group 5 grass pollen allergen family. In this review we summarize current knowledge of the epidemiology and immunology of subtropical Chloridoideae and Pancoideae pollen allergens, describe the biochemical characteristics of known isoforms and variants as well as properties and structures of subtropical pollen allergen components. Whilst only one subtropical allergen component; Cyn d 1 of Bermuda grass pollen, is available commercially for diagnostic use, in a natural purified form, a number of allergens of Panicoideae grass pollen; Zea m 1, Zea m 3 and Zea m 13 of maize, Pas n 1 and Pas n 13 of Bahia, as well as Sor h 1, Sor h 2, Sor h 13 and Sor h 23 of Johnson grass, have been discovered. Research effort is directed towards making available subtropical grass pollen allergen components as innovative treatment and diagnostic options that more specifically address the needs of patients from warmer regions of the globe.



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The Revision Rhinoplasty Consult: The Art of Managing Expectations.

Facial plast Surg 2018; 34: 287-289
DOI: 10.1055/s-0038-1655734

Rhinoplasty is widely acknowledged to be a challenging operation. The success of the operation has long been measured in anecdotal ways. As the surgeon—do I think the outcome is good? Does the patient tell me they are happy? At hand is an obvious issue with patients sometimes not returning to their original doctor. Other times they may have minor concerns that take minimal effort to correct. Does that constitute a revision? In most circles, the ultimate definition of revision rhinoplasty is a return to surgery with the intent to correct a functional or aesthetic concern that arose after the original procedure.
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Functional Compromise in the Middle Vault in the Management of Revision Rhinoplasty

Facial plast Surg 2018; 34: 239-244
DOI: 10.1055/s-0038-1654677

As rhinoplasty procedures become more common, the need for revision surgeries increases as well. Unlike primary rhinoplasties, revision rhinoplasties can be more challenging because of anatomic differences from initial surgery, a lack of available cartilage, tissue remodeling responses, and other complications. As such, surgeons should be prepared to address revision rhinoplasty patients differently from primary rhinoplasty patients. Here, the authors describe a generalizable approach to revision functional rhinoplasty patients and detail some of the surgical techniques that can be employed to achieve optimal outcomes, with particular attention paid to procedures that can be used in the middle vault.
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Use of Translucent Template in the Reconstruction of Nasal Defects: A Novel Technique

Facial plast Surg 2018; 34: 339-340
DOI: 10.1055/s-0038-1653991

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Failure of Synthetic Implants: Strategies and Management

Facial plast Surg 2018; 34: 245-254
DOI: 10.1055/s-0038-1654676

Dorsal augmentation with synthetic implants is the most commonly performed rhinoplasty procedure, especially in the East-Asian region. However, as in all other surgical procedures, complications are inevitable. Complications that need to be managed surgically include displacement, deviation, suboptimal aesthetic outcome, extrusion, inflammation, infection, and changes in skin quality. Most complications can be easily managed with revision surgery. After the removal of the synthetic implant from the nasal dorsum, different dorsal implant materials such as dermofat, alloderm, or fascia-wrapped diced cartilage, conchal cartilage with perichondrial attachment, and costal cartilage are preferred. An irreversible change in the skin/soft tissue envelope poses a challenge that usually requires reconstructive surgery with a local flap. Therefore, early detection and prompt management of the complication are essential for minimizing the severity of the deformity and the complexity of the surgical procedures.
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Bilateral Tessier Type 3 Cleft—Repairment in a Single Session

Facial plast Surg 2018; 34: 335-336
DOI: 10.1055/s-0038-1653985

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The Twisted Nose: What to Do When It's Not Straight

Facial plast Surg 2018; 34: 255-260
DOI: 10.1055/s-0038-1653987

Septorhinoplasty is among the most common facial plastic and reconstructive surgeries and its complexities are reflected in a relatively high revision rate. The patient with a postoperative twisted nose presents an additional challenge and requires that the surgeon display empathy and possess a deep knowledge of the aesthetic and functional intricacies of the nose. Correction of the twisted nose should be approached in a systematic fashion with unique considerations for each "third" of the nose. While there are many options in the overall surgical armamentarium, each surgeon will find specific techniques that are most efficacious and reproducible for their individual practice. This article discusses select surgical "pearls" and techniques that can aid the surgeon in their own surgical decision-making.
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Dissatisfaction with Nasal Tip Shape: Secondary Tip Maneuvers

Facial plast Surg 2018; 34: 278-286
DOI: 10.1055/s-0038-1653988

Dissatisfaction with the appearance of the nasal tip is a common compliant in patients seeking revision surgery after rhinoplasty. Revision rhinoplasty is more technically difficult and unpredictable given the frequent presence of scar contracture, impaired skin envelope quality, and missing alar cartilage. This article describes some of the more common causes for tip revision surgery and techniques to address these abnormalities.
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Dorsal Failures: From Saddle Deformity to Pollybeak

Facial plast Surg 2018; 34: 261-269
DOI: 10.1055/s-0038-1653990

The nasal dorsum is an important component of a rhinoplasty and may be the primary motivation for seeking surgery. The nasal dorsum is a complex three-dimensional shape that is shrouded by local anesthetic and edema during surgery. This makes an accurate assessment of the surgical changes challenging. Complications related to dorsal modification include imbalances from over- or underresection of the structures of the nasal dorsum, inadequate or overaugmentation, an open-roof deformity, pollybeak, saddle nose, inverted-V, warped cartilage, visible grafts, contour problems, graft malposition, and extrusion. This review will discuss the common problems that can occur with dorsal modification during rhinoplasty.
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Cleft Rhinoplasty: Strategies for the Multiply Operated Nose

Facial plast Surg 2018; 34: 290-297
DOI: 10.1055/s-0038-1653986

Rhinoplasty, as a surgical procedure to improve the appearance of the nose while preserving or improving function, is complicated and difficult to master. Revision cleft rhinoplasty offers another tier of challenge. The symmetry, proportions, and definition of the nose are affected by the native cleft deformity but also previous surgical scars, cartilage grafts, and skin excisions. Our preferred approach is to use structural cartilage grafting to establish septal and lower lateral cartilage resiliency. Internal lining deficiency is addressed with skin or lining transfer, while excess nasal tip thickness is contoured to improve definition. Of the utmost importance, the cleft nasal deformity cannot be considered in isolation, but rather a combined amalgamation of the lip muscle and scar, dentofacial occlusion, and skeletal maxillary deficiency.
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The Art of Camouflage: When Can a Revision Rhinoplasty Be Nonsurgical?

Facial plast Surg 2018; 34: 270-277
DOI: 10.1055/s-0038-1653989

Rhinoplasty surgery is known to have revision rates up to 20%. Surgical revisions include the risk of anesthesia and scarring. The skilled injector may offer nonsurgical alternatives to patients when considering revision surgery. Injections can be done to improve symmetry or improve/camouflage deformities that are possibly too minor for surgery but bothersome to the patient. Injections can be performed using different filler materials, but these treatments also carry inherent risks.
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Surgical Tips for the Management of the Wide Nasal Base

Facial plast Surg 2018; 34: 337-338
DOI: 10.1055/s-0038-1653984

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Rhinoplasty: Why Do Revisions Still Occur?

Facial plast Surg 2018; 34: 237-238
DOI: 10.1055/s-0038-1654678

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Satisfaction with Facial Appearance and Quality of Life after Treatment of Face Scars with a Transparent Facial Pressure Mask

Facial plast Surg
DOI: 10.1055/s-0038-1648249

Treatment of facial hypertrophic scars and deformities has developed from the use of elastic fabric hoods to transparent facemasks. The clinical effects of these masks have been described. However, the psychological impact of wearing such a mask is not well documented. The aim of this study was to assess patients' satisfaction with their current facial appearance, to assess the end result of facemask therapy, and to assess the decision to have undergone facemask therapy by means of four different FACE-Q questionnaires. Out of the eligible 87 patients who completed the facemask therapy between January 2012 and November 2017, 42 filled out the questionnaires. These patients wore a custom-fabricated facemask because of facial hypertrophic scars and severe postsurgical facial irregularities. Patients who wore the mask 12 to 16 hours per day were significantly more satisfied with the end result compared with those who wore it 4 to 8 hours daily. Also, patients who wore the mask 8 to 12 and 12 to 16 hours each day were more satisfied to have undergone therapy compared with those who wore it 4 to 8 hours daily. Furthermore, patients who finished therapy 3 to 4 years and 4 to 5 years ago reported a significant higher satisfaction with facial appearance compared with those who completed therapy in a time period shorter than 1 year ago. Patients who finished therapy 3 to 4 years ago reported higher satisfaction with their facial appearance compared with those who finished therapy 2 to 3 years ago. Additionally, the Patient and Observer Scar Assessments Score (POSAS) showed a significant reduction between start and end of therapy. This study shows facemask therapy to result in long-lasting stable results. It also shows a longer daily wearing of the facemask to result in the highest satisfaction according to patients.
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Food-induced Anaphylaxis in Infants and Children

Publication date: Available online 1 June 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Waheeda Samady, Jennifer Trainor, Bridget Smith, Ruchi Gupta
BackgroundRecent recommendations to introduce peanut products to infants for peanut allergy prevention requires a focused assessment of infant anaphylaxis.ObjectiveThis study describes the symptomatology of food-induced anaphylaxis (FIA) in infants (<12 months) compared to older pediatric cohorts.MethodsRetrospective review between June 2015 and June 2017 of children presenting with FIA at a large urban children's hospital emergency department (ED).ResultsA total of 357 cases of FIA were evaluated: 47 in infants (<12 months), 43 in toddlers (12 to 24 months), 96 in young children (2 to 6 years), and 171 in school-aged children (>6 years). Infants presented with gastrointestinal (GI) involvement more frequently than any other age group (89% vs 63% [P = .003], 60% [P <.001], and 58% [P <.001]). Additionally, infants and young children presented with skin involvement more frequently than school-aged children (94% and 91% vs 62% [P <.001]). Respiratory symptoms were more common in older cohorts (17% in infants vs 44% in young children [P <.001] and 54% in school-aged children [P <.001]). Egg and cow's milk were more common causes of FIA in infants compared to school-aged children (egg, 38% vs 1% [P <.001]; milk, 17% vs 7% [P =.03]). Only 21% of infants with FIA had eczema and 36% had a history of food allergy.ConclusionInfants with FIA primarily presented with GI and skin manifestations. Egg was the most common food trigger in infants. Most infants with FIA did not have eczema or a history of food allergy.



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Changes in chronic rhinosinusitis symptoms differentially associate with improvement in general health-related quality of life

Publication date: Available online 1 June 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Marlene M. Speth, Lloyd P. Hoehle BA, Katie M. Phillips, David S. Caradonna, Stacey T. Gray, Ahmad R. Sedaghat




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Are there different subtypes of eosinophilic esophagitis?

Publication date: Available online 1 June 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Jay Adam Lieberman




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Bedroom Exposure to Airborne Allergens in the Chicago Area Using a Patient-Operated Sampling Device

Publication date: Available online 1 June 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Julian Gordon, Paul Detjen, Sai Nimmagadda, Laura Rogers, Sanjay Patel, James Thompson, Rachel Reboulet, Prasanthi Gandhi
Background: In current practice, allergens in vacuum collected dust are used as surrogates for inhalable allergens. We developed an airsampling device that can be used by patients themselves for direct measurement of airborne allergen concentrations in their own homes.Objective: To demonstrate the use of this device to establish allergen concentration reference ranges in a target population. To evaluate relationships of patient-reported information to measured allergen concentrations.Methods: Patients from 5 allergist's practices in the Chicagoland region were provided with instructions, questionnaire, informed consent forms and samplers to run for 5 days in their bedrooms. Samples were collected from cartridges and assayed by multiplex immunoassays for 12 common household allergens and ELISA for ragweed.Results: Unique allergen profiles were obtained for 102 patient homes. Samples with allergen concentrations above the limit of detection were: total dust mite: 28%; cat, 61%; dog, 64%; mouse, 12%; rat, 0%; cockroach, 4%; Alternaria, 6%; Aspergillus, 21%; birch pollen 1%; grass, 8%; ragweed, 5%. Of those, 75 completed questionnaires, providing meta-data for further analysis. Pet allergens correlated significantly with number of pets owned. Humidity correlated with dust mite allergens, open windows with Alternaria and mouse allergens, HEPA filter use with reduced levels of several allergens. Many other variables showed no significant correlations.Conclusion: The combination of ease of use, high air sampling rate and sensitive immunoassays permitted the measurement of airborne allergens concentrations in homes and establishment of reference ranges. Patientreported information permitted identification of factors that could relate to allergen concentrations and suggest remedial measures.



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The extent of vestibular impairment is important in recovery of canal paresis of patients with vestibular neuritis

We questioned whether the extent of vestibular impairment affected the recovery of vestibular function in acute vestibular neuritis (VN). The objective of this study was to identify how the extent of vestibular impairment influenced the recovery from canal paresis (CP) in patients with VN.

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Reply to: comment on “Liquid nitrogen cryotherapy for chronic recalcitrant interdigital candidiasis of toe-spaces – an uncontrolled pilot study”

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About melanocyte activation in idiopathic guttate hypomelanosis by 5-fluorouracil tattooing

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Folliculitis Decalvans: Effectiveness of Therapies and Prognostic Factors In A Multicenter Series of 60 Patients With Long-Term Follow-Up

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Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w) in patients with seborrheic keratoses: results from two identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)

Capsule Summary

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Influence of age and marital status on stage at diagnosis and survival of patients with Merkel cell carcinoma: a SEER based cohort study

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A cross-sectional study of clinical distinctions between neuropathic and inflammatory pruritus

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REPLY to MS#JAAD-D-18-00380

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“Soft corn versus Candidiasis!”

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A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis

Previous studies found conflicting results about whether atopic dermatitis (AD) begins in adulthood.

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Post-Partum Thrombotic Thrombocytopenic Purpura (TTP) in a Patient with known Idiopathic (Immune) Thrombocytopenic Purpura: a case report and review of the literature

Incidences of immune thrombocytopenic purpura occur in 1 in every 1000–10,000 pregnancies accounting for 3% of all thrombocytopenic pregnancies. A pre-existing immune thrombocytopenic purpura is known to be a ...

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Postpartum acute fatty liver of pregnancy: a case report

Acute fatty liver of pregnancy can be a very dramatic clinical event with significant risk of mortality to healthy women. The pathogenesis is still unknown. It usually occurs in the third trimester or in the i...

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TNFAIP3 (A20) – The Immunological Rheostat

Publication date: Available online 1 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Asher Maroof, Dhavalkumar D. Patel




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Auto-antibodies to IgE and FceRI and the Natural Variability of SYK Expression in Basophils

Publication date: Available online 1 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Donald MacGlashan
BackgroundSecretion from human basophils and mast cells requires the activity of SYK but expression of SYK is highly variable in the general population and this variability predicts the magnitude of IgE-mediated secretion. One known mechanism of modulating SYK expression in human basophils is aggregation of FceRI.ObjectiveThis study examines the possibility that functional auto-antibodies are present in a wide variety of subjects and in particular, subjects whose basophils poorly express SYK. It also tests whether any found antibodies could modulate SYK expression in maturing basophils and whether interaction with FcgRIIb/CD32b modulates the effect.MethodsAn experimental algorithm for classifying the nature of histamine release induced by serum from 3 classes of subjects was developed.ResultsThe frequency of functional auto-antibodies that produce characteristics concordant with FceRI-mediated secretion was zero in 34 subjects without chronic spontaneous urticaria (CSU). In subjects with CSU, the frequency was lower than expected, approximately 7%. For the 5/68 unique CSU sera tested that contained anti-FceRI or anti-IgE Abs, these antibodies were found to induce down-regulation of SYK in both peripheral blood basophils and basophils developed from CD34+ progenitors. Blocking interaction of these antibodies with CD32b did not alter their ability to down-regulate SYK expression.ConclusionsThis study establishes that functional auto-antibodies to IgE/FceRI do not provide a good explanation for the variability in SYK expression in basophils in the general population. They do show that if antibodies with these characteristics are present, they are capable of modulating SYK expression in developing basophils.

Teaser

The wide variability in the critical signaling tyrosine kinase SYK observed in the general population is not explained by the presence of auto-antibodies to IgE or FceRIalpha.


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Hemodynamic Management of Patients During Endovascular Treatment of Acute Ischemic Stroke Under Conscious Sedation: A Retrospective Cohort Study

Background: Anesthetic modality and hemodynamic management during mechanical thrombectomy (MT) for acute ischemic stroke (AIS) are potential contributors to the success of revascularization. The aims of our study were to review the hemodynamic management by anesthesiologists and clinical outcomes in patients undergoing MT under conscious sedation. Methods: Retrospective cohort study of patients with anterior circulation AIS from January 2012 to March 2016. Primary outcome was hemodynamic intervention, defined as administration of vasoactive drugs to maintain systolic blood pressure (BP) between 140 and 180 mm Hg. The secondary outcome was poor hemodynamic control, defined as BP outside target for >15 minutes despite hemodynamic intervention. We performed regression analysis to determine the predictors of hemodynamic intervention and poor hemodynamic control. Results: A total of 126 patients were included in this study; 92% (116) receiving conscious sedation and 8% (10) no sedation. Upon arrival to the neuroradiology suite, systolic BP was 180 mm Hg in 14.3%. Hemodynamic intervention was required in 38.9% of patients; 15.1% for hypotension and 19.8% for hypertension. In the multivariate analysis, systolic BP on hospital admission (odds ratio, 1.02; 95% confidence interval, 1.00-1.04; P=0.019) constituted a predictor for hemodynamic intervention. Poor hemodynamic control occurred in 12.7% of patients, with lower baseline systolic BP being associated with higher risk of intraprocedural hypotension (odds ratio, 0.92; 95% confidence interval, 0.89-0.96; P

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A low cost and stepwise training model for skull base repair using a suturing and knotting technique during endoscopic endonasal surgery

Abstract

Purpose

Cerebrospinal fluid leakage is always the primary complication during the endoscopic endonasal skull base surgery. Dural suturing technique may supply a rescue method. However, suturing and knotting in such a deep and narrow space are difficult. Training in the model can improve skills and setting a stepwise curriculum can increase trainers' interest and confidence.

Methods

We constructed an easy model using silicone and acrylic as sphenoid sinus and using the egg-shell membrane as skull base dura. The training is divided into three steps: Step 1: extracorporeal knot-tying suture on the silicone of sphenoid sinus, Step 2: intra-nasal knot-tying suture on the same silicone, and Step 3: intra-nasal egg-shell membrane knot-tying suture. Fifteen experienced microneurosurgical neurosurgeons (Group A) and ten inexperienced PGY residents (Group B) were recruited to perform the tasks. Performance measures were time, suturing and knotting errors, and needle and thread manipulations. The third step was assessed through the injection of full water into the other side of the egg to verify the watertight suture. The results were compared between two groups.

Results

Group A finishes the first and second tasks in significantly less time (total time, 125.1 ± 10.8 vs 195.8 ± 15.9 min) and fewer error points (2.4 ± 1.3 vs 5.3 ± 1.0) than group B. There are five trainers in group A who passed the third step, this number in group B was only one.

Conclusions

This low cost and stepwise training model improved the suture and knot skills for skull base repair during endoscopic endonasal surgery. Experienced microneurosurgical neurosurgeons perform this technique more competent.

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Chapter 17 - Gunslingers, poker players, and chickens 3: Decision making under mental performance pressure in junior elite athletes

Parkin, BL; Walsh, V; (2017) Chapter 17 - Gunslingers, poker players, and chickens 3: Decision making under mental performance pressure in junior elite athletes. Progress in Brain Research , 234 pp. 339-359. 10.1016/bs.pbr.2017.08.011 .

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Chapter 16 - Gunslingers, poker players, and chickens 2: Decision-making under physical performance pressure in subelite athletes

Parkin, BL; Walsh, V; (2017) Chapter 16 - Gunslingers, poker players, and chickens 2: Decision-making under physical performance pressure in subelite athletes. Progress in Brain Research , 234 pp. 317-338. 10.1016/bs.pbr.2017.08.010 .

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Chapter 15 - Gunslingers, poker players, and chickens 1: Decision making under physical performance pressure in elite athletes

Parkin, BL; Warriner, K; Walsh, V; (2017) Chapter 15 - Gunslingers, poker players, and chickens 1: Decision making under physical performance pressure in elite athletes. Progress in Brain Research , 234 pp. 291-316. 10.1016/bs.pbr.2017.08.001 .

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Prognosis in Cardiac Amyloidosis by LGE

Fontana, M; (2016) Prognosis in Cardiac Amyloidosis by LGE. JACC: Cardiovascular Imaging , 9 (6) pp. 687-689. 10.1016/j.jcmg.2015.11.028 . Green open access

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Strategic investment explains patterns of cooperation and cheating in a microbe

Madgwick, PG; Stewart, B; Belcher, LJ; Thompson, CRL; Wolf, JB; (2018) Strategic investment explains patterns of cooperation and cheating in a microbe. Proceedings of the National Academy of Sciences of The United States of America (PNAS) , 115 (21) E4823-E4823. 10.1073/pnas.1716087115 . Green open access

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Erratum to: Safety of zidovudine/lamivudine scored tablets in children with HIV infection in Europe and Thailand

Bailey, H; Thompson, L; Childs, T; Collins, IJ; Tostevin, A; Goodall, R; Goetghebuer, T; ... Judd, A; + view all Bailey, H; Thompson, L; Childs, T; Collins, IJ; Tostevin, A; Goodall, R; Goetghebuer, T; Spoulou, V; Galli, L; Marczynska, M; Marques, L; Ene, L; Samarina, A; Rosenberg, V; Dodonov, K; Okhonskaia, L; Noguera Julian, A; Rojo Conejo, P; Ramos Amador, JT; Naver, L; Jourdain, G; Thorne, C; Giaquinto, C; Judd, A; - view fewer (2017) Erratum to: Safety of zidovudine/lamivudine scored tablets in children with HIV infection in Europe and Thailand. European Journal of Clinical Pharmacology , 73 (4) p. 469. 10.1007/s00228-017-2201-y . Green open access

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Assessment of the model refinement category in CASP12

Hovan, L; Oleinikovas, V; Yalinca, H; Kryshtafovych, A; Saladino, G; Gervasio, FL; (2017) Assessment of the model refinement category in CASP12. Proteins - Structure. Function and Bioinformatics , 86 pp. 152-167. 10.1002/prot.25409 .

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Episodic medication adherence in adolescents and young adults with perinatally acquired HIV: a within-participants approach

Hawkins, A; Evangeli, M; Sturgeon, K; Le Prevost, M; Judd, A; (2016) Episodic medication adherence in adolescents and young adults with perinatally acquired HIV: a within-participants approach. AIDS Care , 28 pp. 68-75. 10.1080/09540121.2016.1146210 . Green open access

https://ift.tt/2smAmdE

Evolving adoptive cellular therapies in urological malignancies

Wong, YNS; Joshi, K; Pule, M; Peggs, KS; Swanton, C; Quezada, SA; Linch, M; (2017) Evolving adoptive cellular therapies in urological malignancies. Lancet Oncology , 18 (6) E341-E353. 10.1016/S1470-2045(17)30327-3 . Green open access

https://ift.tt/2HdFwNM

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Biswas, A; Shouval, DS; Griffith, A; Goettel, JA; Field, M; Kang, YH; Konnikova, L; ... Snapper, SB; + view all Biswas, A; Shouval, DS; Griffith, A; Goettel, JA; Field, M; Kang, YH; Konnikova, L; Janssen, E; Redhu, NS; Thrasher, AJ; Chatila, T; Kuchroo, VK; Geha, RS; Notarangelo, LD; Pai, S-Y; Horwitz, BH; Snapper, SB; - view fewer (2018) WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nature Communications , 9 , Article 1779. 10.1038/s41467-018-03670-6 . Green open access

https://ift.tt/2kHzMTO

Verification bias

O'Sullivan, JW; Banerjee, A; Heneghan, C; Pluddemann, A; (2018) Verification bias. BMJ Evidence-Based Medicine , 23 (2) pp. 54-55. 10.1136/bmjebm-2018-110919 . Green open access

https://ift.tt/2HbptQL

Cardiac-Specific Expression of ΔH2-R15 Mini-Dystrophin Normalized All Electrocardiogram Abnormalities and the End-Diastolic Volume in a 23-Month-Old Mouse Model of Duchenne Dilated Cardiomyopathy

Wasala, NB; Shin, J-H; Lai, Y; Yue, Y; Montanaro, F; Duan, D; (2018) Cardiac-Specific Expression of ΔH2-R15 Mini-Dystrophin Normalized All Electrocardiogram Abnormalities and the End-Diastolic Volume in a 23-Month-Old Mouse Model of Duchenne Dilated Cardiomyopathy. Human Gene Therapy 10.1089/hum.2017.144 . (In press).

https://ift.tt/2kDOpr0

Multi-parametric mixed integer linear programming under global uncertainty

Charitopoulos, VM; Papageorgiou, LG; Dua, V; (2018) Multi-parametric mixed integer linear programming under global uncertainty. Computers and Chemical Engineering 10.1016/j.compchemeng.2018.04.015 . (In press). Green open access

https://ift.tt/2H8Asdv

Psychological therapies for treatment-resistant depression in adults

Ijaz, S; Davies, P; Williams, CJ; Kessler, D; Lewis, G; Wiles, N; (2018) Psychological therapies for treatment-resistant depression in adults. Cochrane Database of Systematic Reviews , 5 , Article CD010558. 10.1002/14651858.CD010558.pub2 .

https://ift.tt/2sk8nvp

Visual attention control differences in 12-month-old preterm infants

Downes, M; Kelly, D; Day, K; Marlow, N; de Haan, M; (2018) Visual attention control differences in 12-month-old preterm infants. Infant Behavior and Development , 50 pp. 180-188. 10.1016/j.infbeh.2018.01.002 .

https://ift.tt/2HalzYp

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma

Kieran, MW; Chisholm, J; Casanova, M; Brandes, AA; Aerts, I; Bouffet, E; Bailey, S; ... Geoerger, B; + view all Kieran, MW; Chisholm, J; Casanova, M; Brandes, AA; Aerts, I; Bouffet, E; Bailey, S; Leary, S; MacDonald, TJ; Mechinaud, F; Cohen, KJ; Riccardi, R; Mason, W; Hargrave, D; Kalambakas, S; Deshpande, P; Tai, F; Hurh, E; Geoerger, B; - view fewer (2017) Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma. Neuro-Oncology , 19 (11) pp. 1542-1552. 10.1093/neuonc/nox109 .

https://ift.tt/2spa2jd

Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data

Marioni, RE; Suderman, M; Chen, BH; Horvath, S; Bandinelli, S; Morris, T; Beck, S; ... Hägg, S; + view all Marioni, RE; Suderman, M; Chen, BH; Horvath, S; Bandinelli, S; Morris, T; Beck, S; Ferrucci, L; Pedersen, NL; Relton, CL; Deary, IJ; Hägg, S; - view fewer (2018) Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data. The Journals of Gerontology: Series A 10.1093/gerona/gly060 . (In press). Green open access

https://ift.tt/2sxvSAx

Miocene to recent extension in NW Sulawesi, Indonesia

Advokaat, EL; Hall, R; White, LT; Watkinson, IM; Rudyawan, A; BouDagher-Fadel, MK; (2017) Miocene to recent extension in NW Sulawesi, Indonesia. Journal of Asian Earth Sciences , 147 pp. 378-401. 10.1016/j.jseaes.2017.07.023 .

https://ift.tt/2kHxdko

Suite2p: beyond 10,000 neurons with standard two-photon microscopy

Pachitariu, M; Stringer, C; Dipoppa, M; Schröder, S; Rossi, LF; Dalgleish, H; Carandini, M; Pachitariu, M; Stringer, C; Dipoppa, M; Schröder, S; Rossi, LF; Dalgleish, H; Carandini, M; Harris, KD; - view fewer (2017) Suite2p: beyond 10,000 neurons with standard two-photon microscopy. BioRxiv: Cold Spring Harbor, NY, USA. Green open access

https://ift.tt/2sxKa3R

The role of partners' educational attainment in the association between HIV and education amongst women in seven sub-Saharan African countries

Harling, G; Bärnighausen, T; (2016) The role of partners' educational attainment in the association between HIV and education amongst women in seven sub-Saharan African countries. Journal of the International AIDS Society , 19 (1) , Article 20038. 10.7448/IAS.19.1.20038 . Green open access

https://ift.tt/2kII0Lo

A low cost and stepwise training model for skull base repair using a suturing and knotting technique during endoscopic endonasal surgery

Abstract

Purpose

Cerebrospinal fluid leakage is always the primary complication during the endoscopic endonasal skull base surgery. Dural suturing technique may supply a rescue method. However, suturing and knotting in such a deep and narrow space are difficult. Training in the model can improve skills and setting a stepwise curriculum can increase trainers' interest and confidence.

Methods

We constructed an easy model using silicone and acrylic as sphenoid sinus and using the egg-shell membrane as skull base dura. The training is divided into three steps: Step 1: extracorporeal knot-tying suture on the silicone of sphenoid sinus, Step 2: intra-nasal knot-tying suture on the same silicone, and Step 3: intra-nasal egg-shell membrane knot-tying suture. Fifteen experienced microneurosurgical neurosurgeons (Group A) and ten inexperienced PGY residents (Group B) were recruited to perform the tasks. Performance measures were time, suturing and knotting errors, and needle and thread manipulations. The third step was assessed through the injection of full water into the other side of the egg to verify the watertight suture. The results were compared between two groups.

Results

Group A finishes the first and second tasks in significantly less time (total time, 125.1 ± 10.8 vs 195.8 ± 15.9 min) and fewer error points (2.4 ± 1.3 vs 5.3 ± 1.0) than group B. There are five trainers in group A who passed the third step, this number in group B was only one.

Conclusions

This low cost and stepwise training model improved the suture and knot skills for skull base repair during endoscopic endonasal surgery. Experienced microneurosurgical neurosurgeons perform this technique more competent.

https://ift.tt/2J4syUm

Evaluating the impact of translated written discharge instructions for patients with limited English language proficiency

Publication date: August 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 111
Author(s): Minyoung Jang, Michal J. Plocienniczak, Kian Mehrazarin, Wasif Bala, Kevin Wong, Jessica R. Levi
IntroductionPatients with limited English language proficiency have indicated that they believe post-operative instructions written in their native language will improve comprehension over verbal translation alone, but the effect of this has not been previously studied. We hypothesize that providing written discharge instructions in Spanish for native Spanish speakers will improve comprehension regarding post-operative care after routine otolaryngologic procedures when compared to instructions written in English.MethodsThis prospective randomized controlled trial enrolled subjects who met criteria from June 2016 to November 2016. Subjects were Spanish-speaking parents and legal guardians of children undergoing tympanostomy tube insertion, adenoidectomy, and/or tonsillectomy. Subjects were given written discharge instructions in either English or Spanish. Both cohorts received standard verbal counseling in Spanish as well. Primary outcome was score on a standardized quiz assessing comprehension of discharge instructions. Patient satisfaction and preferences were secondary outcomes assessed through a survey. Participants underwent follow up one month after initial enrollment.ResultsTwenty subjects were enrolled, with ten receiving written discharge instructions in Spanish and ten receiving instructions written in English. There was no significant difference in comprehension scores between the two groups. Eleven participants completed the survey on patient satisfaction and preferences. Most subjects (91%, 10/11, p<0.01) preferred written instructions in their native language and subjectively felt this would improve their comprehension. However, there was no significant effect on patient satisfaction.ConclusionsSpanish-speaking patients indicate a strong preference for written discharge instructions in their native language, although there was no significant difference in short-term comprehension of instructions written in English vs. Spanish on objective evaluation. Accommodating these preferences may improve long-term comprehension and patient satisfaction, and ultimately build invaluable rapport between providers and patients.



https://ift.tt/2xBCdk8

A Call for Doctors to Lead the Charge for Antibiotic-Free Foods

Agricultural antibiotics are responsible for roughly 20 percent of resistant infections in humans according to the Centers for Disease Control and Prevention, however, its urgency as a public health concern has been understated. Martin Makary, M.D., M.P.H., a professor of surgery at the Johns Hopkins University School of Medicine, insists that doctors start leading the way for antibiotic-free foods in the same way they advocate for smoking cessation.

https://ift.tt/2LaIsNI

Pembrolizumab for Nasopharyngeal Carcinoma Patients With Detectable Plasma Epstein-Barr Virus DNA

Condition:   Immunotherapy With Pembrolizumab for Nasopharyngeal Carcinoma Patients
Intervention:   Drug: Pembrolizumab
Sponsors:   National Health Research Institutes, Taiwan;   National Taiwan University Hospital;   Koo Foundation Sun Yat-Sen Cancer Center;   Chang Gung Memorial Hospital;   Taichung Veterans General Hospital;   China Medical University Hospital;   Changhua Christian Hospital;   National Cheng-Kung University Hospital
Not yet recruiting

https://ift.tt/2IZ4YMK

PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL

Conditions:   Solid Tumor, Adult;   Head and Neck Cancer;   Non Small Cell Lung Cancer;   Pancreatic Cancer;   Diffuse Large B Cell Lymphoma
Intervention:   Drug: CX-2029
Sponsor:   CytomX Therapeutics
Not yet recruiting

https://ift.tt/2swd3gU

Histiocytic Necrotizing Lymphadenitis Involving the Neck: Radiology-Pathology Correlation

Abstract

Histiocytic necrotizing lymphadenitis is an uncommon autoimmune condition characterized by fever, leukopenia, and neck swelling. Diagnostic imaging, including ultrasound and CT, typically demonstrates conglomerates of enlarged cervical lymph nodes with hypervascular cortices and areas of necrosis. Ultimately, the diagnosis is confirmed with the histopathologic findings of paracortical coagulative necrosis with karyorrhectic debris, abundant histiocytes, and absence of neutrophils. Other potential etiologies, such as other causes of infectious lymphadenitis, tuberculosis, lymphoma, and systemic lupus erythematosus, must be excluded. These features are exemplified in this sine qua non radiology–pathology correlation article.

https://ift.tt/2sxrEsv

The Relationships Between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-Related Costs

BACKGROUND Recent changes in policies guiding allocation of transplant kidneys are predicted to increase sharing between distant geographic regions. The potential exists for an increase in cold ischemia time (CIT) with resulting increases in delayed graft function (DGF) and transplant-related costs (TRC). We sought to explore the impact of CIT on metrics that may influence TRC. METHODS Between 2006 and 2014, 81,945 adult solitary deceased donor kidney transplants (KT) were performed in the United States; 477 (0.6%) at our institution. Regression models were constructed to describe the relationship between CIT on DGF and length of stay (LOS). Using hospital accounting data, we created regression models to evaluate the effect of DGF on LOS and TRC. RESULTS In multivariable models, longer CIT was associated with an increased rate of DGF (odds ratio [OR] 1.41; 95% confidence interval [CI] 1.38-1.44) and increased LOS (1.04; 1.02-1.05). Recipients at our institution who developed DGF had longer LOS (1.71; 1.50-1.95), suggesting that the effect is partially mediated by DGF. After adjusting for LOS, neither CIT nor DGF were independently associated with increased TRC. However, an increased LOS resulted in an increase in TRC by $3422 (95% CI: $3180 - $3664) per additional day, indicating that the effect of CIT on TRC is partially mediated through LOS. CONCLUSION The prolongation of CIT is associated with an increase in DGF rates and LOS, resulting in increased TRC. This study raises the need to balance increased access of traditionally-underserved populations to KT with the inadvertent increase in TRC. Presented at the American Transplant Congress 2016 (Boston, MA). Correspondence: Oscar K. Serrano, MD, Department of Surgery, Division of Transplantation, 420 Delaware Street SE, Mayo Mail Code 195, Minneapolis, MN 55455. Email: serra01@umn.edu Authorship: •Participated in research design: Serrano, Vock, Matas, Finger. •Participated in the writing of the paper: Serrano, Vock, Finger. •Participated in the editing of the paper: Serrano, Vock, Chinnakotla, Dunn, Kandaswamy, Pruett, Feldman, Matas, Finger. •Participated in the performance of the research: Serrano, Chinnakotla, Dunn, Kandaswamy, Pruett, Matas, Finger. •Contributed new reagents or analytic tools: Vock, Feldman •Participated in data analysis: Serrano, Vock, Matas, Finger. Disclosure: The authors declare no conflicts of interest. Funding: The authors declare no funding received for this work. DISCLAIMER The data reported here have been supplied by the Minneapolis Medical Research Foundation (MMRF) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2soX05o

Donor Specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients

Introduction The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA detected by screening patients with a stable creatinine remains unclear. Methods 103 patients

https://ift.tt/2xwPlXI

Evaluation of surgery and surgical results of Baha® Attract system implantations – single centre experience of hundred twenty five cases

Publication date: Available online 31 May 2018
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Wojciech Gawęcki, Andrzej Balcerowiak, Ewelina Kalinowicz, Maciej Wróbel
IntroductionBone-anchored hearing aids are currently well-established solutions for treatment of hearing-impaired patients.ObjectiveTo evaluate the surgery of the Baha^® Attract system, healing process and soft tissue condition after the processor activation.Methods125 patients implanted with the Baha^® Attract system during a 4 year period in a single ENT department were analysed. Evaluated parameters comprised: details of surgery, healing process and soft tissue condition at the time of the processor activation and on subsequent follow-up visits.ResultsThe implantation was conducted under local anaesthesia in 96% of patients. The mean surgery time was 42min. Soft tissue reduction was performed in 43.2% of cases; bone polishing in 23.2% and bipolar coagulation in all the cases. Healing was uneventful in 92.8%. 10 days after the surgery, pain was reported in 48% of cases. On subsequent follow-up visits, 1 month and 3 months after the surgery, pain was present in 18.4% and 2.4% of cases respectively. Similarly, numbness and paresthesia, initially reported in 84% and 15.2%, were present in 60% and 11.2% after a month, and in 17.6% and 1.6% after three months. After the processor attachment, no serious problems were observed in the analysed group during follow-up visits. However, mild redness and/or mild pain over the magnet were observed in 9.6% of patients.ConclusionImplantation of the Baha^® Attract system is an easy and safe procedure. It can be performed under local anaesthesia in adults. There are no major surgical problems or complications, and the healing process proceeds efficiently in most patients. Postoperative pain is usually mild and gradually decreases in the following months. Numbness in the operated area is frequent, but as reinnervation occurs in time, the numb patch decreases in size and finally completely disappears in most cases.



https://ift.tt/2LOQIUS

Six-minute walk test (6MWT) in AL amyloidosis - baseline and 12-month follow-up after chemotherapy

Flatman, K; Foard, D; Pyart, E; Hughes, G; Gaudia, R; Kearney, C; Elmi, I; ... Lane, T; + view all Flatman, K; Foard, D; Pyart, E; Hughes, G; Gaudia, R; Kearney, C; Elmi, I; Bangova, A; Libo-On, P; Caringal-Galima, J; Rowles, E; Guillotte, C; Hawkins, P; Gillmore, J; Lane, T; - view fewer (2017) Six-minute walk test (6MWT) in AL amyloidosis - baseline and 12-month follow-up after chemotherapy. Presented at: 15th International Symposium on Amyloidosis, Uppsala, SWEDEN. Green open access

https://ift.tt/2soaiyW

Stable coronary disease: Cinderella must go to the ball

Banerjee, A; (2016) Stable coronary disease: Cinderella must go to the ball. European Heart Journal - Quality of Care and Clinical Outcomes , 2 (3) pp. 151-152. 10.1093/ehjqcco/qcw022 . Green open access

https://ift.tt/2sxNtIv

Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy

Namous, H; Peñagaricano, F; Del Corvo, M; Capra, E; Thomas, DL; Stella, A; Williams, JL; ... Khatib, H; + view all Namous, H; Peñagaricano, F; Del Corvo, M; Capra, E; Thomas, DL; Stella, A; Williams, JL; Marsan, PA; Khatib, H; - view fewer (2018) Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy. BMC Genomics , 19 , Article 123. 10.1186/s12864-018-4509-0 . Green open access

https://ift.tt/2kFISjJ

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

Hoffman, LM; Veldhuijzen van Zanten, SEM; Colditz, N; Baugh, J; Chaney, B; Hoffmann, M; Lane, A; ... Fouladi, M; + view all Hoffman, LM; Veldhuijzen van Zanten, SEM; Colditz, N; Baugh, J; Chaney, B; Hoffmann, M; Lane, A; Fuller, C; Miles, L; Hawkins, C; Bartels, U; Bouffet, E; Goldman, S; Leary, S; Foreman, NK; Packer, R; Warren, KE; Broniscer, A; Kieran, MW; Minturn, J; Comito, M; Broxson, E; Shih, C-S; Khatua, S; Chintagumpala, M; Carret, AS; Escorza, NY; Hassall, T; Ziegler, DS; Gottardo, N; Dholaria, H; Doughman, R; Benesch, M; Drissi, R; Nazarian, J; Jabado, N; Boddaert, N; Varlet, P; Giraud, G; Castel, D; Puget, S; Jones, C; Hulleman, E; Modena, P; Giagnacovo, M; Antonelli, M; Pietsch, T; Gielen, GH; Jones, DTW; Sturm, D; Pfister, SM; Gerber, NU; Grotzer, MA; Pfaff, E; von Bueren, AO; Hargrave, D; Solanki, GA; Jadrijevic Cvrlje, F; Kaspers, GJL; Vandertop, WP; Grill, J; Bailey, S; Biassoni, V; Massimino, M; Calmon, R; Sanchez, E; Bison, B; Warmuth-Metz, M; Leach, J; Jones, B; van Vuurden, DG; Kramm, CM; Fouladi, M; - view fewer (2018) Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries. Journal of Clinical Oncology 10.1200/JCO.2017.75.9308 . (In press).

https://ift.tt/2sDB5XB

Estotilandi taassünd

Kuldkepp, M; (2008) Estotilandi taassünd. Vihik. Eesti Kirjanduse Seltsi kvartaliajakiri , 13/14 pp. 66-72.

https://ift.tt/2kJpwdv

Assessing the Variance in Pupil Attainment: How Important is the School Attended?

Wilkinson, D; Bryson, A; Stokes, L; (2018) Assessing the Variance in Pupil Attainment: How Important is the School Attended? National Institute Economic Review , 243 (1) R4-R16. 10.1177/002795011824300110 . Green open access

https://ift.tt/2sDAXY7

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Swisher, EM; Lin, KK; Oza, AM; Scott, CL; Giordano, H; Sun, J; Konecny, GE; ... McNeish, IA; + view all Swisher, EM; Lin, KK; Oza, AM; Scott, CL; Giordano, H; Sun, J; Konecny, GE; Coleman, RL; Tinker, AV; O'Malley, DM; Kristeleit, RS; Ma, L; Bell-McGuinn, KM; Brenton, JD; Cragun, JM; Oaknin, A; Ray-Coquard, I; Harrell, MI; Mann, E; Kaufmann, SH; Floquet, A; Leary, A; Harding, TC; Goble, S; Maloney, L; Isaacson, J; Allen, AR; Rolfe, L; Yelensky, R; Raponi, M; McNeish, IA; - view fewer (2017) Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. Lancet Oncology , 18 (1) pp. 75-87. 10.1016/S1470-2045(16)30559-9 . Green open access

https://ift.tt/2sm0o0Y

‘A Close and Unbreachable Distance’: Witnessing Everything and Nothing

Harker, CG; (2007) 'A Close and Unbreachable Distance': Witnessing Everything and Nothing. An International Journal for Critical Geographies , 6 (1) pp. 51-72. Green open access

https://ift.tt/2syDtP0

Trustees, Tax and Disclosure - The HMRC Dimension

Agnew, SC; (2007) Trustees, Tax and Disclosure - The HMRC Dimension. [Review]. Jersey and Guernsey Law Review , 2007 (1) pp. 72-73.

https://ift.tt/2kH8Pj6

Barbara Drake Boehm and Jiří Fajt, eds. Prague: The Crown of Bohemia, 1347-1437

Zusi, PA; (2007) Barbara Drake Boehm and Jiří Fajt, eds. Prague: The Crown of Bohemia, 1347-1437. [Review]. Slavic and East European Journal , 51 (3) pp. 637-639. 10.2307/20459548 .

https://ift.tt/2HbuRDn

Postoperative Care Handbook of the Massachusetts General Hospital

No abstract available

https://ift.tt/2kGWF9G

Starving Patients Before Cataract Surgery Under Regional Anesthesia: Needed or Not?

No abstract available

https://ift.tt/2swuJZL

Race/Ethnicity and Sex Both Affect Opioid Administration in the Emergency Room

BACKGROUND: Although racial/ethnic and sex disparities have been examined in health care generally and pain management more specifically, the combined influence of these sociodemographic factors together has not been well documented. The aim of this study was to examine the association between administration of opioid analgesics in the emergency department (ED) and interaction of race/ethnicity and sex. METHODS: We conducted a retrospective cohort study using 2010–2014 Center for Disease Control-National Hospital Ambulatory Medical Care Survey data for patients 12–55 years of age presenting to EDs with a primary diagnosis of appendicitis or gallbladder disease as defined by International Classification of Diseases, Ninth Revision codes. The primary outcome was the receipt of opioid analgesic medications. Secondary outcomes included: receipt of nonopioids, receipt of antiemetic medications, wait time to see a provider, and length of visit in the ED. The association between sex and analgesic receipt within Caucasian non-Hispanic and non-Caucasian groups was evaluated adjusting for pain score on presentation, patient age, emergent status, city/noncity location, number of comorbidities, time of visit (month, day of the week, standard versus nonstandard working hours, year), and US region. RESULTS: After exclusions, a weighted sample of 553 ED visits was identified, representing 2,622,926 unique visits. The sample population was comprised of 1,858,035 (70.8%) females and 1,535,794 (58.6%) Caucasian non-Hispanics. In adjusted models, Caucasian non-Hispanic males 317,427/525,435 (60.4%) were slightly less likely to receive opioids than Caucasian non-Hispanic females 621,638/1,010,360 (61.5), odds ratio = 0.962, 95% CI, 0.955–0.970; P

https://ift.tt/2J0U09A

Fibrinogen Concentrate in Cardiovascular Surgery: A Meta-analysis of Randomized Controlled Trials

BACKGROUND: Postoperative bleeding remains a frequent complication after cardiovascular surgery and may contribute to serious morbidity and mortality. Observational studies have suggested a relationship between low endogenous plasma fibrinogen concentration and increased risk of postoperative blood loss in cardiac surgery. Although the transfusion of fibrinogen concentrate has been increasing, potential benefits and risks associated with perioperative fibrinogen supplementation in cardiovascular surgery are not fully understood. METHODS: PubMed, Cochrane Library, Ovid MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure were searched on January 15, 2017, with automated updates searched until February 15, 2018, to identify all randomized controlled trials (RCTs) of fibrinogen concentrate, whether for prophylaxis or treatment of bleeding, in adults undergoing cardiovascular surgery. All RCTs comparing fibrinogen infusion versus any other comparator (placebo/standard of care or another active comparator) in adult cardiovascular surgery and reporting at least 1 predefined clinical outcome were included. The random-effects model was used to calculate risk ratios and weighted mean differences (95% confidence interval [CI]) for dichotomous and continuous variables, respectively. Subgroup analyses by fibrinogen dose and by baseline risk for bleeding were preplanned. RESULTS: A total of 8 RCTs of fibrinogen concentrate in adults (n = 597) of mixed risk or high risk undergoing cardiovascular surgery were included. Compared to placebo or inactive control, perioperative fibrinogen concentrate did not significantly impact risk of all-cause mortality (risk ratio, 0.41; 95% CI, 0.12–1.38; I2 = 10%; P = .15). Fibrinogen significantly reduced incidence of allogeneic red blood cell transfusion (risk ratio, 0.64; 95% CI, 0.49–0.83; I2 = 0%; P = .001). No significant differences were found for other clinical outcomes. Subgroup analyses were unremarkable when analyzed according to fibrinogen dose, time of infusion initiation, mean cardiopulmonary bypass time, and rotational thromboelastometry/fibrinogen temogram use (all P values for subgroup interaction were nonsignificant). CONCLUSIONS: Current evidence remains insufficient to support or refute routine perioperative administration of fibrinogen concentrate in patients undergoing cardiovascular surgery. Fibrinogen concentrate may reduce the need for additional allogeneic blood product transfusion in cardiovascular surgery patients at high risk or with evidence of bleeding. However, no definitive advantage was found for reduction in risk of mortality or other clinically relevant outcomes. The small number of clinical events within existing randomized trials suggests that further well-designed studies of adequate power and duration to measure all-cause mortality, stroke, myocardial infarction, reoperation, and thromboembolic events should be conducted. Future studies should also address cost-effectiveness relative to standard of care. Accepted for publication April 30, 2018. Funding: This work was supported by the Department of Anesthesia and Perioperative Medicine, Western University. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Janet Martin, PharmD, MSc(HTA&M), Department of Anesthesia and Perioperative Medicine, Schulich School of Medicine & Dentistry, Western University, University Hospital, Room C3-412, 339 Windermere Rd, London, ON N6A 5A5, Canada. Address e-mail to jmarti83@uwo.ca. © 2018 International Anesthesia Research Society

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Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain

BACKGROUND: Neuropathic pain is often associated with depression. Enhancing endocannabinoids by fatty acid amide hydrolase (FAAH) inhibitors relieves neuropathic pain and stress-induced depressive-like behaviors in animal models. However, it is unclear whether FAAH inhibitor can relieve neuropathic pain–induced depression by or not by its antinociceptive effects. METHODS: Adult male Wistar rats with chronic constriction injury (CCI) to the sciatic nerve were treated with the systemic FAAH inhibitor URB597 (5.8 mg·kg−1·day−1, intraperitoneally) or peripherally acting FAAH inhibitor URB937 (1.6 mg·kg−1·d−1, intraperitoneally; n = 11–12). The treatment was applied from the 15th day after surgery and continued for 15 days. Mechanical withdrawal threshold was examined by Von Frey test before surgery and on the 28th day after CCI. Depressive-like behaviors were evaluated by forced swimming test (FST) and novelty-suppressed feeding (NSF) after 15-day treatment. The levels of anandamide and 2-arachidonoylglycerol in hippocampus were examined by liquid chromatography and mass spectrometry. Hippocampal neurogenesis including proliferation, differentiation, and survival of newborn cells was assessed by immunohistochemistry. RESULTS: After CCI injury, the rats developed significantly nociceptive and depressive-like behaviors, indicated by persistent mechanical hypersensitivity in Von Frey test, significantly prolonged immobility time in FST (sham: 84.2 ± 13.4 seconds versus CCI: 137.9 ± 18.8 seconds; P

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Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections: The VIPER-OCTA Randomized Clinical Pilot Trial

BACKGROUND: Thoracic aorta dissection is an acute critical condition associated with shock-induced endotheliopathy, coagulopathy, massive bleeding, and significant morbidity and mortality. Our aim was to compare the effect of coagulation support with solvent/detergent-treated pooled plasma (OctaplasLG) versus standard fresh frozen plasma (FFP) on glycocalyx and endothelial injury, bleeding, and transfusion requirements. METHODS: Investigator-initiated, single-center, blinded, randomized clinical pilot trial of adult patients undergoing emergency surgery for thoracic aorta dissection. Patients were randomized to receive OctaplasLG or standard FFP as coagulation factor replacement related to bleeding. The primary outcome was glycocalyx and endothelial injury. Other outcomes included bleeding, transfusions and prohemostatics at 24 hours, organ failure, length of stay in the intensive care unit and in the hospital, safety, and mortality at 30 and 90 days. RESULTS: Fifty-seven patients were included to obtain 44 evaluable on the primary outcome. The OctaplasLG group displayed significantly reduced damage to the endothelial glycocalyx (syndecan-1) and reduced endothelial tight junction injury (sVE-cadherin) compared to standard FFP. In the OctaplasLG group compared to the standard FFP, days on ventilator (1 day [interquartile range, 0–1] vs 2 days [1–3]; P = .013), bleeding during surgery (2150 [1600–3087] vs 2750 [2130–6875]; P = .046), 24-hour total transfusion and platelet transfusion volume (3975 mL [2640–6828 mL] vs 6220 mL [4210–10,245 mL]; P = .040, and 1400 mL [1050–2625 mL] vs 2450 mL [1400–3500 mL]; P = .027), and goal-directed use of prohemostatics (7/23 [30.4%] vs 13/21 [61.9%]; P = .036) were all significantly lower. Among the 57 patients randomized, 30-day mortality was 20.7% (6/29) in the OctaplasLG group and 25% (7/28) in the standard FFP group (P = .760). No safety concern was raised. CONCLUSIONS: In this randomized, clinical pilot trial of patients undergoing emergency surgery for thoracic aorta dissections, we found that OctaplasLG reduced glycocalyx and endothelial injury, reduced bleeding, transfusions, use of prohemostatics, and time on ventilator after surgery compared to standard FFP. An adequately powered multicenter trial is warranted to confirm the clinical importance of the findings. Accepted for publication May 8, 2018. Funding: This investigator-initiated trial was funded by internal department funds and an unrestricted research grant from Octapharma AG, the manufacturer of OctaplasLG, paid to and administered by Copenhagen University Hospital, Rigshospitalet, to support the execution of the trial covering expenses to assisting staff, on-call research assistants, blood samples, laboratory analyses, etc. Octapharma AG also supplied the investigational product of the trial free of charge. None of the authors involved have received ­personal income from Octapharma AG, have shares or financial interests in Octapharma AG, and Octapharma AG had no role in the design of this study, its execution, analysis, interpretation of the data, writing of the article, or decision to submit results. Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). The trial was registered before patient enrollment at clinicaltrials.gov (NCT02253082, principal investigator: J.S.; date of registration: October 1, 2014). Reprints will not be available from the authors. Address correspondence to Jakob Stensballe, PhD, Section for Transfusion Medicine, Capital Region Blood Bank and Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK-2100, Denmark. Address e-mail to jakob.stensballe@regionh.dk. © 2018 International Anesthesia Research Society

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Foreword

Mantouvalou, Virginia; (2018) Foreword. UCL Journal of Law and Jurisprudence , 7 (1) vi-vii. 10.14324/111.2052-1871.092 . Green open access

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Report on open access article processing charges paid from University College London’s open access funds, 2017-18

Sharp, CL; (2018) Report on open access article processing charges paid from University College London's open access funds, 2017-18. UCL Library Services: London, UK. Green open access

https://ift.tt/2Jky0G5

Report on open access for University College London papers funded by the UK Research Councils, 2017-18

Sharp, CL; (2018) Report on open access for University College London papers funded by the UK Research Councils, 2017-18. UCL Library Services: London, UK. Green open access

https://ift.tt/2Laf75U

Extracting the late-time kinetic Sunyaev-Zel'dovich effect

Munshi, D; Iliev, IT; Dixon, KL; Coles, P; (2016) Extracting the late-time kinetic Sunyaev-Zel'dovich effect. Monthly Notices of the Royal Astronomical Society (MNRAS) , 463 (3) pp. 2425-2442. 10.1093/mnras/stw2067 . Green open access

https://ift.tt/2JkBJna

Exploring the application domain of adaptive structures

Senatore, G; Duffour, P; Winslow, P; (2018) Exploring the application domain of adaptive structures. Engineering Structures , 167 pp. 608-628. 10.1016/j.engstruct.2018.03.057 . Green open access

https://ift.tt/2LeZ6Mi

3D weak lensing: Modified theories of gravity

Pratten, G; Munshi, D; Valageas, P; Brax, P; (2016) 3D weak lensing: Modified theories of gravity. Physical Review D , 93 (10) , Article 103524. 10.1103/PhysRevD.93.103524 . Green open access

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Learning in temporary multi-organizations: Improving performance and constructing identities

Sergeeva, N; Roehrich, J; (2018) Learning in temporary multi-organizations: Improving performance and constructing identities. Industrial Marketing Management (In press).

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A Dendritic Nickel Cobalt Sulfide Nanostructure for Alkaline Battery Electrodes

Li, W; Zhang, B; Lin, R; Ho-Kimura, S; He, G; Zhou, X; Hu, J; Li, W; Zhang, B; Lin, R; Ho-Kimura, S; He, G; Zhou, X; Hu, J; Parkin, IP; - view fewer (2018) A Dendritic Nickel Cobalt Sulfide Nanostructure for Alkaline Battery Electrodes. Advanced Functional Materials 10.1002/adfm.201705937 . (In press). Green open access

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Phase behaviour and applications of a binary liquid mixture of methanol and a thermotropic liquid crystal.

Serrano, LA; Fornerod, MJ; Yang, Y; Gaisford, S; Stellacci, F; Guldin, S; (2018) Phase behaviour and applications of a binary liquid mixture of methanol and a thermotropic liquid crystal. Soft Matter 10.1039/c8sm00327k . (In press). Green open access

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Innovation and storytelling

Sergeeva, N; (2017) Innovation and storytelling. In: (Proceedings) The XXVIII ISPIM Innovation Conference. ISPIM: Vienna. Green open access

https://ift.tt/2JkBc4E

Genomic epidemiology of Shigella in the United Kingdom shows transmission of pathogen sublineages and determinants of antimicrobial resistance

Baker, KS; Dallman, TJ; Field, N; Childs, T; Mitchell, H; Day, M; Weill, F-X; ... Thomson, N; + view all Baker, KS; Dallman, TJ; Field, N; Childs, T; Mitchell, H; Day, M; Weill, F-X; Lefèvre, S; Tourdjman, M; Hughes, G; Jenkins, C; Thomson, N; - view fewer (2018) Genomic epidemiology of Shigella in the United Kingdom shows transmission of pathogen sublineages and determinants of antimicrobial resistance. Science Reports , 8 (1) , Article 7389. 10.1038/s41598-018-25764-3 . Green open access

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Simulation Experiment Description Markup Language (SED-ML) Level 1 Version 3 (L1V3)

Bergmann, FT; Cooper, J; König, M; Moraru, I; Nickerson, D; Le Novère, N; Olivier, BG; ... Waltemath, D; + view all Bergmann, FT; Cooper, J; König, M; Moraru, I; Nickerson, D; Le Novère, N; Olivier, BG; Sahle, S; Smith, L; Waltemath, D; - view fewer (2018) Simulation Experiment Description Markup Language (SED-ML) Level 1 Version 3 (L1V3). Journal of Integrative Bioinformatics , 15 (1) , Article 20170086. 10.1515/jib-2017-0086 . Green open access

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Tuberculosis infection and disease in people living with HIV in countries with low tuberculosis incidence

Winter, JR; adamu, AL; Gupta, RK; Stagg, HR; Delpech, V; Abubakar, I; (2018) Tuberculosis infection and disease in people living with HIV in countries with low tuberculosis incidence. International Journal of Tuberculosis and Lung Disease 10.5588/ijtld.17.0672 . (In press).

https://ift.tt/2LbOFJ6

Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro

Wilson, ER; Kugathasan, U; Abramov, AY; Clark, AJ; Bennett, DLH; Reilly, MM; Greensmith, L; Wilson, ER; Kugathasan, U; Abramov, AY; Clark, AJ; Bennett, DLH; Reilly, MM; Greensmith, L; Kalmar, B; - view fewer (2018) Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro. Neurobiology of Disease , 117 pp. 1-14. 10.1016/j.nbd.2018.05.008 . Green open access

https://ift.tt/2JnegSf

Defining Street-based Local Area and measuring its effect on house price using a hedonic price approach: The case study of Metropolitan London

Law, S; (2017) Defining Street-based Local Area and measuring its effect on house price using a hedonic price approach: The case study of Metropolitan London. Cities , 60 (A) pp. 166-179. 10.1016/j.cities.2016.08.008 . Green open access

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Global statistics on alcohol, tobacco and illicit drug use: 2017 status report

Peacock, A; Leung, J; Larney, S; Colledge, S; Hickman, M; Rehm, J; Giovino, GA; ... Degenhardt, L; + view all Peacock, A; Leung, J; Larney, S; Colledge, S; Hickman, M; Rehm, J; Giovino, GA; West, R; Hall, W; Griffiths, P; Ali, R; Gowing, L; Marsden, J; Ferrari, AJ; Grebely, J; Farrell, M; Degenhardt, L; - view fewer (2018) Global statistics on alcohol, tobacco and illicit drug use: 2017 status report. Addiction 10.1111/add.14234 . (In press).

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PAPEETE: Private, Authorized, and Fast Personal Genomic Testing

Perillo, AM; De Cristofaro, E; (2018) PAPEETE: Private, Authorized, and Fast Personal Genomic Testing. In: (Proceedings) 15th International Conference on Security and Cryptography (SECRYPT 2018). (In press).

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Parents' Experiences of Caring for Their Child at the Time of Discharge After Cardiac Surgery and During the Postdischarge Period: Qualitative Study Using an Online Forum

Wray, J; Brown, K; Tregay, J; Crowe, S; Knowles, R; Bull, K; Gibson, F; (2018) Parents' Experiences of Caring for Their Child at the Time of Discharge After Cardiac Surgery and During the Postdischarge Period: Qualitative Study Using an Online Forum. Journal of Medical Internet Research , 20 (5) , Article e155. 10.2196/jmir.9104 . Green open access

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Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naive Patient: A Comprehensive Review of the Literature

Pimolbutr, K; Porter, S; Fedele, S; (2018) Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naive Patient: A Comprehensive Review of the Literature. BioMed Research International , 2018 , Article 8071579. 10.1155/2018/8071579 . Green open access

https://ift.tt/2L7TVxi

Aristotle on the Structure of Akratic Action

Cagnoli Fiecconi, E; (2018) Aristotle on the Structure of Akratic Action. Phronesis , 63 (3) pp. 229-256. 10.1163/15685284-12341350 .

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