Pediatric Dermatology, EarlyView.
https://ift.tt/2Hia1nG
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Παρασκευή 6 Απριλίου 2018
Apocrine hidrocystoma on the genitalia of a 9‐year‐old girl
Idiopathic facial aseptic granuloma—A diagnostic challenge in pediatric dermatology
Pediatric Dermatology, EarlyView.
https://ift.tt/2Esr4A2
A case of extensive acquired progressive lymphangioma
Pediatric Dermatology, EarlyView.
https://ift.tt/2Hi9z8Y
Occult dysraphism presenting with acro‐osteolysis
Pediatric Dermatology, EarlyView.
https://ift.tt/2Es0Uxm
Compound heterozygous mutations in desmoplakin associated with skin fragility, follicular hyperkeratosis, alopecia, and nail dystrophy
Pediatric Dermatology, EarlyView.
https://ift.tt/2Hi9qSY
Evidence‐based dosing of maintenance subcutaneous immunotherapy: a contemporary review of state‐of‐the‐art practice
International Forum of Allergy &Rhinology, EarlyView.
https://ift.tt/2qdWMwP
American Society for Enhanced Recovery: Advancing Enhanced Recovery and Perioperative Medicine
As the population ages, the increasing surgical volume and complexity of care are expected to place additional care delivery burdens in the perioperative setting. In this age of integrated multidisciplinary care of the surgical patients, there is increasing recognition that an evidence-based perioperative pathway is associated with the optimal outcomes. These pathways, collectively referred to as Enhanced Recovery Pathways, have resulted in shortened length of hospital stay, reduced complications, and variance in outcomes, as well as earlier return to baseline activities. The American Society for Enhanced Recovery (ASER) is a multispecialty, nonprofit international organization, dedicated to the practice of enhanced recovery in perioperative patients through education and research. Perioperative Quality Initiatives were formed whose intent is to organize a series of consensus conferences on topics of interest related to perioperative medicine. The journal affiliation between American Society for Enhanced Recovery and Anesthesia& Analgesia will enable these evidence-based practices to be disseminated widely and swiftly to the practicing perioperative health care professionals so they can be adopted to improve the quality of perioperative surgical care. Accepted for publication March 12, 2018. Funding: None. Conflicts of Interest: See Disclosures at the end of the article. Reprints will not be available from the authors. Address correspondence to Tong J. Gan, MD, MBA, MHS, FRCA, Department of Anesthesiology, Stony Brook University, HSC Level 4, Rm 060, Stony Brook, NY 11794. Address e-mail to tong.gan@stonybrookmedicine.edu. © 2018 International Anesthesia Research Society
https://ift.tt/2uRHhj3
https://ift.tt/2uRHhj3
Dezocine Alleviates Morphine-Induced Dependence in Rats
BACKGROUND: Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS: Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test. Buprenorphine and vehicle solution containing 20% (v/v) dimethyl sulfoxide were used for positive and negative control, respectively. The astrocytes activation in nucleus accumbens was assessed by immunofluorescence assay of glial fibrillary acidic protein. Effect of dezocine and buprenorphine on the internalization of κ opioid receptor (KOR) was investigated using Neuro2A expressing KOR fused to red fluorescent protein tdTomato (KOR-tdT). Buprenorphine and dezocine were screened against 44 G-protein–coupled receptors, ion channels, and transporter proteins using radioligand-binding assay to compare the molecular targets. RESULTS: The mean withdrawal score was reduced in rats treated with 1.25 mg·kg−1 dezocine compared to vehicle-treated control animals starting from the day 1 (mean difference: 7.8; 95% confidence interval [CI], 6.35–9.25; P
https://ift.tt/2JsGb02
https://ift.tt/2JsGb02
Diagnostic Accuracy of Point-of-Care Gastric Ultrasound
BACKGROUND: Pulmonary aspiration of gastric contents is associated with significant perioperative morbidity and mortality. Previous studies have investigated the validity, reliability, and possible clinical impact of gastric ultrasound for the assessment of gastric content at the bedside. In the present study, we examined the accuracy (evaluated as sensitivity, specificity, and likelihood ratios) of point-of-care gastric ultrasound to detect a "full stomach" in a simulated scenario of clinical equipoise. METHODS: After a minimum fasting period of 8 hours, 40 healthy volunteers were randomized in a 1:1 ratio to either remain fasted or ingest a standardized quantity of clear fluid or solid. Each subject was randomized twice on 2 independent study sessions at least 24 hours apart. A gastric ultrasound examination was performed by a blinded sonographer following a standardized scanning protocol. Using a combination of qualitative and quantitative findings, the result was summarized in a dichotomous manner as positive (any solid or >1.5 mL/kg of clear fluid) or negative (no solid and ≤1.5 mL/kg of clear fluid) for full stomach. RESULTS: Data from 80 study sessions were analyzed. In this simulated clinical scenario with a pretest probability of 50%, point-of-care gastric ultrasound had a sensitivity of 1.0 (95% confidence interval [CI], 0.925–1.0), a specificity of 0.975 (95% CI, 0.95–1.0), a positive likelihood ratio of 40.0 (95% CI, 10.33–∞), a negative likelihood ratio of 0 (95% CI, 0–0.072), a positive predictive value of 0.976 (95% CI, 0.878–1.0), and a negative predictive value of 1.0 (95% CI, 0.92–1.0). CONCLUSIONS: Our results suggest that bedside gastric ultrasound is highly sensitive and specific to detect or rule out a full stomach in clinical scenarios in which the presence of gastric content is uncertain. Accepted for publication February 27, 2018. Funding: This study was supported by a peer-reviewed grant from Physician Services Incorporated, Ontario, Canada. Conflicts of Interest: See Disclosures at the end of the article. Trial Registry Number: Registration ID: NCT02588495. Reprints will not be available from the authors. Address correspondence to Anahi Perlas, MD, FRCPC, Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Department of Anesthesia, University of Toronto, 399 Bathurst St, McLaughlin Pavilion 2–405, Toronto, ON M5T 2S8, Canada. Address e-mail to anahi.perlas@uhn.ca. © 2018 International Anesthesia Research Society
https://ift.tt/2qbEFrq
https://ift.tt/2qbEFrq
Profound Intraoperative Hypotension Associated With Transfusion via the Belmont Fluid Management System
This retrospective observational case series conducted at 2 large academic centers over a 4-year period consists of 15 cases of profound hypotension in surgical patients immediately after initiation of the Belmont Fluid Management System for rapid transfusion of blood products. Halting the infusion and administering vasoactive agents led to resolution of hypotension. Repeat transfusion with the Belmont system resulted in repeat hypotension unless counteracted with vasopressors. No etiology was elucidated. This represents the largest documented association of acute hypotensive transfusion reaction with any rapid infusion system in surgical patients. Accepted for publication February 1, 2018. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Joanna Miller, MD, Mount Sinai Hospital, 1 Gustave Levy Pl, New York, NY 10129. Address e-mail to joanna.miller@mountsinai.org. © 2018 International Anesthesia Research Society
https://ift.tt/2ErII71
https://ift.tt/2ErII71
Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial
BACKGROUND: In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with propofol. METHODS: Forty-eight patients were enrolled and randomly assigned to either a dexmedetomidine group (n = 24), which received a loading dose of 1 μg/kg dexmedetomidine over 10 minutes, followed by a continuous infusion of 0.1–0.5 μg·kg−1·hour−1, or a propofol group (n = 24), which received a continuous infusion of propofol via a target-controlled infusion to maintain the effect-site concentration within a range of 0.5–2.0 μg/mL. The drug infusion rate was determined according to the sedation level, targeting a modified observer's assessment of alertness/sedation score of 3 or 4. The cumulative amounts of fentanyl administered via intravenous patient-controlled analgesia were recorded at 24 and 48 hours postoperatively (primary outcome). The postoperative numerical rating scale for pain was assessed at 6, 12, 24, and 48 hours (secondary outcome). The postoperative use of additional rescue analgesic (ketoprofen) and antiemetic drugs was also compared between the 2 groups at 24 and 48 hours. RESULTS: Dexmedetomidine significantly reduced postoperative fentanyl consumption (median [interquartile range]) during 0–24 hours (45 [30–71] vs 150 [49–248] μg, P = .004; median difference = −105 μg [99.98% CI, 210–7.5]), 24–48 hours (90 [45–143] vs 188 [75–266] μg, P = .005; median difference = −98 μg [99.98% CI, 195–45]), and 0–48 hours (135 [68–195] vs 360 [146–480] μg, P = .003; median difference = −225 μg [99.98% CI, 405–7.5]). The numerical rating scale (median [interquartile range]) was lower at 6 hours (1 [0–2] vs 2 [1–3], P = .003), 12 hours (1 [1–2] vs 3 [2–3], P
https://ift.tt/2ErU1fE
https://ift.tt/2ErU1fE
Urban versus Rural Residency and Allergy Prevalence among Adult Women: Iowa Women's Health Study
The association between residence and allergy has been well studied in children living on a farm; however, studies of this association in late adulthood are lacking.
https://ift.tt/2uQNf3o
Treatment of nevoid hyperkeratosis of the areola and nipple with topical tacalcitol: A case report
Dermatologic Therapy, EarlyView.
https://ift.tt/2ErHN6K
Reconstruction of a buttock defect after excision of inflammatory linear verrucous epidermal nevus
Dermatologic Therapy, EarlyView.
https://ift.tt/2HhChqw
Impact of oncogene panel results on surgical management of cytologically indeterminate thyroid nodules
Head &Neck, EarlyView.
https://ift.tt/2qc5ZVz
Behaviors of active sunbeds users and their knowledge on the potential health risks; results of cross‐sectional study in Poland
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2GCqmX7
Effect of voice therapy on vocal fold polyp treatment
Abstract
Purpose
To investigate the role of voice therapy (VT) and factors that may affect the response to VT in the treatment of vocal fold polyps, especially as a complement to phonosurgery.
Methods
Retrospective review of patients with vocal fold polyp undergoing surgery and/or VT in a tertiary medical center. The demographic data, phoniatric history, videolaryngostroboscopic findings, polyp characteristics, VHI-10 and GRB scores, and voice analysis data were recorded before and after the treatment. The patients were grouped as those who had undergone endolaryngeal microsurgery only (Group S), those who had first received VT then undergone surgery due to inadequate VT outcome (Group VTpS), and those who had only undergone VT with a follow-up plan (Group VT).
Results
Data were reviewed from 211 (108 M, 103 F) patients with a mean age of 41.3 ± 11 years. The improvement in all voice-related variables observed in the S and VTpS groups was significantly greater compared to the VT group despite the degree of improvement achieved in this group. At the end of the treatment period, improvements in G-R-B, VHI-10 and stroboscopy scores were significantly greater in the VTpS group than in the S and VT groups.
Conclusion
Voice therapy can improve voice quality to some extent during the treatment of vocal fold polyps. However, VT alone is unsatisfactory compared to surgery alone. Pre-surgical VT can enhance the ultimate success of treatment. A young age, small polyps, and short duration of dysphonia may increase the possibility of benefiting from VT.
https://ift.tt/2Hg2plu
Molecular markers in well-differentiated thyroid cancer
Abstract
Purpose
Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described.
Methods
PubMed was used to search relevant articles. The key terms "thyroid nodules", "thyroid cancer papillary", "carcinoma papillary follicular", "carcinoma papillary", "adenocarcinoma follicular" were searched in MeSH, and "molecular markers", "molecular testing", mutation, BRAF, RAS, RET/PTC, PAX 8, miRNA, NIFTP in title and abstract fields. Multiple combinations were done and a group of experts in the subject from the International Head and Neck Scientific Group extracted the relevant articles and formulated the review.
Results
There has been considerable progress in the understanding of thyroid carcinogenesis and the emergence of numerous molecular markers in the recent years with potential to be used in the diagnostic algorithm of these nodules. However, their precise role in routine clinical practice continues to be a contentious issue. Majority of the studies in this context are retrospective and impact of these mutations is not independent of other prognostic factors making the interpretation difficult.
Conclusion
The prevalence of these mutations in thyroid nodule is high and it is a continuously evolving field. Clinicians should stay informed as recommendation on the use of these markers is expected to evolve.
https://ift.tt/2uQiYSp
New Gene Test Reduces Skin Reactions to Carbamazepine
A new gene variant test to guide treatment decisions led to reductions in the incidence of cutaneous adverse reactions to carbamazepine, a new study shows.
Medscape Medical News
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Gastric Emptying During the Labour
Conditions: Pregnancy; Healthy Volunteers; Parturition
Intervention: Other: Ultrasound assessment of gastric emptying of a flavoured yoghourt.
Sponsor: Hospices Civils de Lyon
Not yet recruiting
https://ift.tt/2uN286M
Intervention: Other: Ultrasound assessment of gastric emptying of a flavoured yoghourt.
Sponsor: Hospices Civils de Lyon
Not yet recruiting
https://ift.tt/2uN286M
Avelumab With Chemoradiation for Stage II/III Resectable Esophageal Cancer
Condition: Resectable Esophageal Cancer
Interventions: Combination Product: Avelumab combined with Chemoradiation; Drug: Carboplatin; Drug: Paclitaxel; Radiation: Radiation
Sponsors: University of Wisconsin, Madison; National Cancer Institute (NCI)
Not yet recruiting
https://ift.tt/2HgsmBw
Interventions: Combination Product: Avelumab combined with Chemoradiation; Drug: Carboplatin; Drug: Paclitaxel; Radiation: Radiation
Sponsors: University of Wisconsin, Madison; National Cancer Institute (NCI)
Not yet recruiting
https://ift.tt/2HgsmBw
Topical timolol for Kaposi sarcoma: An innovation
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2GCE5NI
2q24 deletion in a 9-month old girl with anal atresia, hearing impairment, and hypotonia
Publication date: June 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 109
Author(s): Peiwei Zhao, Bing Mao, Xiaonan Cai, Jun Jiang, Zhisheng Liu, Jun Lin, Xuelian He
Deletion of 2q24.2 is a rare cytogenetic aberration in patients, exhibiting heterogeneous clinical features, and common phenotypes included developmental delay, intellectual disability, hypotonia, and mild dysmorphic features. Hearing impairment and anal atresia are rarely described. Here we described a 9-month-old female patient with hypotonia in all four limbs, developmental delay, and intellectual disability. In addition, congenital anal atresia was diagnosed and treated after birth, and hearing impairment was found in right ear. Single nucleotide polymorphisms (SNP) array detected a 5.2 Mb deletion on 2q24.2q24.3, including 19 genes (ITGB6; TBR1; SLC4A10; KCNH7 SCN3A; SCN2A et al.). Among these genes, it is affirmative that TBR1 is a causative gene for intellectual disability; however, the pathogenic genes of other phenotypes remain unclear. We briefly review the knowledge of genes likely involved in these clinical features, including hearing impairment, anal atresia, and developmental delay.
https://ift.tt/2Iz1tbi
Urban versus Rural Residency and Allergy Prevalence among Adult Women: Iowa Women's Health Study
Source:Annals of Allergy, Asthma & Immunology
Author(s): Niharika P. Patel, Anna E. Prizment, Bharat Thyagarajan, Evan Roberts, Heather H. Nelson, Timothy R. Church, DeAnn Lazovich
BackgroundThe association between residence and allergy has been well studied in children living on a farm; however, studies of this association in late adulthood are lacking.ObjectiveThis study examined the association between residence and allergy in 25,393 women aged 55-69 years in the large prospective Iowa Women's Health Study (IWHS).MethodsIWHS questionnaires collected information on socio-demographic and anthropometric characteristics, medical history, lifestyle behaviors, dietary intake, residence and allergy. Residence reported at baseline (1986) was categorized into 5 groups based on living on a farm, rural, or urban areas and population size. Allergy was determined from four self-reported questions about physician-diagnosed asthma, hay fever, skin allergy, and other allergy. Logistic regression was used to determine significant risk factors for allergy and prevalence odds ratios (OR) and 95% confidence intervals (CI) for allergy associated with residence.ResultsCompared to large city of >10,000 residents, those living on farm, rural and smaller urban areas had decreased odds ratios of overall, skin, and other allergy in age and multivariable-adjusted models. The multivariable ORs (95% CI) for farm versus large city were decreased for overall allergy: 0.72 (0.66, 0.78) and all allergy types including asthma: 0.87 (0.75, 1.00), hay fever: 0.77 (0.69, 0.88), skin: 0.76 (0.68, 0.86), and other allergy: 0.76 (0.68, 0.86).ConclusionThis study supports a hypothesis that farm living is inversely associated with allergy, suggesting that environmental exposures may protect against allergy not only in childhood, but also in late adulthood.
https://ift.tt/2H4jPnC
Asthma-chronic obstructive pulmonary disease overlap (ACO): An emerging entity in allergic respiratory diseases
Publication date: April 2018
Source:Allergology International, Volume 67, Issue 2
Author(s): Jun Tamaoki, Kenji Izuhara
https://ift.tt/2JoQPoJ
In vitro effect of Porphyromonas gingivalis combined with influenza A virus on respiratory epithelial cells
Source:Archives of Oral Biology
Author(s): Xin Li, Chen Li, Jun-chao Liu, Ya-ping Pan, Yong-gang Li
ObjectiveRespiratory epithelial cells are the first natural barrier against bacteria and viruses; hence, the interactions among epithelial cells, bacteria, and viruses are associated with disease occurrence and development. The effect of co-infection by P. gingivalis and influenza A virus (IAV) on respiratory epithelial cells remains unknown. The aim of this study was to analyze in vitro cell viability and apoptosis rates in respiratory epithelial A549 cells infected with P. gingivalis or IAV alone, or a combination of both pathogens.DesignA549 cells were first divided into a control group, a P. gingivalis group, an IAV group, and a P. gingivalis + IAV group, to examine cell viability and apoptosis rates, the levels of microtubule associated protein 1 light chain 3 B (LC3-II), microtubule associated protein 1 light chain 3A (LC3-I), and sequestosome 1 (P62), and the formation of autophagosomes. The autophagy inhibitor, 3-methyladenine (3MA), was used to assess autophagy and apoptosis in A549 cells infected with P. gingivalis or IAV.ResultsAn MTT assay revealed that cell viability was significantly lower in the IAV group than in the P. gingivalis + IAV group (P < 0.05). Flow cytometry indicated that the apoptosis rate was significantly higher in the IAV group than in the P. gingivalis + IAV group (P < 0.05). The fluorescence levels of GFP-LC3 increased significantly, the LC3-II/LC3-I ratio was significantly higher, and the P62 protein levels were statistically lower in the P. gingivalis + IAV group compared with the IAV group (all P < 0.05). Western blotting revealed that the LC3- II/LC3-I ratio was significantly lower, and caspase-3 levels were significantly higher in the 3MA + P. gingivalis + IAV group compared to the P. gingivalis + IAV group (all P < 0.05).ConclusionIn vitro studies showed that infection by P. gingivalis combined with IAV temporarily inhibited apoptosis in respiratory epithelial cells, and this may be related to the initiation of autophagy.
https://ift.tt/2qaNvWh
Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones
Bahou, C; Richards, DA; Maruani, A; Love, EA; Javaid, F; Caddick, S; Baker, JR; Bahou, C; Richards, DA; Maruani, A; Love, EA; Javaid, F; Caddick, S; Baker, JR; Chudasama, V; - view fewer (2018) Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones. Organic & Biomolecular Chemistry , 16 (8) pp. 1359-1366. 10.1039/c7ob03138f .
https://ift.tt/2uQYDwg
Agency modulates interactions with automation technologies
Le Goff, K; Rey, A; Haggard, P; Oullier, O; Berberian, B; (2018) Agency modulates interactions with automation technologies. Ergonomics (In press).
https://ift.tt/2H08wwn
Design, Numerical Simulation, and Experimental Evaluation of a Rocking Damage-Free Steel Column Base with Friction Devices
Freddi, F; Dimopoulos, C; Karavasilis, T; (2018) Design, Numerical Simulation, and Experimental Evaluation of a Rocking Damage-Free Steel Column Base with Friction Devices. In: Proceedings of 16th European Conference on Earthquake Engineering. (In press).
https://ift.tt/2IxPPgO
A Bayesian dynamic method to estimate the thermophysical properties of building elements in all seasons, orientations and with reduced error
Gori, V; Biddulph, PD; Elwell, CA; (2018) A Bayesian dynamic method to estimate the thermophysical properties of building elements in all seasons, orientations and with reduced error. Energies , 11 (4) , Article 802. 10.3390/en11040802 . Green open access
https://ift.tt/2q8la34
Homeopathy, Western medicine and the discourse of evidence: negotiating legitimacy in a public online forum
Gibson, WJ; (2019) Homeopathy, Western medicine and the discourse of evidence: negotiating legitimacy in a public online forum. Current Sociology (In press).
https://ift.tt/2uRjYFL
Seismic Performance of Dual Systems with Buckling-Restrained Braces and Moment-Resisting Frames
Tubaldi, E; Freddi, F; Alessandro, Z; Andrea, D; (2018) Seismic Performance of Dual Systems with Buckling-Restrained Braces and Moment-Resisting Frames. In: Proceedings of 16th European Conference on Earthquake Engineering. (In press).
https://ift.tt/2H3tOcw
The effect of composite floor on the robustness of steel self-centering MRFs under column loss
Dimopoulos, C; Freddi, F; Karavasilis, T; Vasdravellis, G; (2018) The effect of composite floor on the robustness of steel self-centering MRFs under column loss. In: Proceedings of 12th International Conference on Advances in Steel-Concrete Composite Structures (ASCCS 2018). Universitat Politècnica de València: València, Spain. (In press).
https://ift.tt/2Ius899
The Use of Picture Cards to Elicit Postgraduate Dental Student Feedback
Fine, PD; Leung, A; Francis, J; Francis, J; Louca, C; (2018) The Use of Picture Cards to Elicit Postgraduate Dental Student Feedback. Dentistry Journal , 6 (2) , Article 7. 10.3390/dj6020007 . Green open access
https://ift.tt/2qcfUeD
Feedforward neural control of toe walking in humans
Lorentzen, J; Willerslev-Olsen, M; Hüche Larsen, H; Svane, C; Forman, C; Frisk, R; Farmer, SF; ... Nielsen, JB; + view all Lorentzen, J; Willerslev-Olsen, M; Hüche Larsen, H; Svane, C; Forman, C; Frisk, R; Farmer, SF; Kersting, U; Nielsen, JB; - view fewer (2018) Feedforward neural control of toe walking in humans. Journal of Physiology 10.1113/JP275539 . (In press).
https://ift.tt/2IyA7lC
Suitability of different approaches for analyzing and predicting the behavior of decomposed volcanic rocks
Okewalale, IA; Coop, MR; (2018) Suitability of different approaches for analyzing and predicting the behavior of decomposed volcanic rocks. Journal of Geotechnical and Geoenvironmental Engineering (In press).
https://ift.tt/2qcfDs7
Observance, Notes Towards Decipherability
Smith, MD; (2018) Observance, Notes Towards Decipherability. Journal of Visual Culture (In press). Green open access
https://ift.tt/2IB0Yh4
Exploring nest structures of acorn dwelling ants with x-ray microtomography and surface based 3D visibility graph analysis
Varoudis, T; Swenson, AG; Kirkton, SD; Waters, JS; (2018) Exploring nest structures of acorn dwelling ants with x-ray microtomography and surface based 3D visibility graph analysis. Philosophical Transactions B: Biological Sciences (In press). Green open access
https://ift.tt/2qcfoNJ
On The Application of Digital Moving Target Indication Techniques to Short-Range FMCW Radar Data
Ash, M; Ritchie, M; Chetty, K; (2018) On The Application of Digital Moving Target Indication Techniques to Short-Range FMCW Radar Data. IEEE Sensors Journal (In press).
https://ift.tt/2uTni3m
Experimental Support That Natural Selection Has Shaped the Latitudinal Distribution of Mitochondrial Haplotypes in Australian Drosophila melanogaster
Camus, MF; Wolff, JN; Sgrò, CM; Dowling, DK; (2017) Experimental Support That Natural Selection Has Shaped the Latitudinal Distribution of Mitochondrial Haplotypes in Australian Drosophila melanogaster. Molecular Biology and Evolution , 34 (10) pp. 2600-2612. 10.1093/molbev/msx184 .
https://ift.tt/2q8j3vY
Mitonuclear epistasis and mitochondrial disease
Morrow, EH; Camus, MF; (2017) Mitonuclear epistasis and mitochondrial disease. Mitochondrion , 35 pp. 119-122. 10.1016/j.mito.2017.06.001 .
https://ift.tt/2uTn8Ji
German Public Support for Tobacco Control Policy Measures: Results from the German Study on Tobacco Use (DEBRA), a Representative National Survey
Boeckmann, M; Kotz, D; Shahab, L; Brown, J; Kastaun, S; (2018) German Public Support for Tobacco Control Policy Measures: Results from the German Study on Tobacco Use (DEBRA), a Representative National Survey. International Journal of Environmental Research and Public Health (In press).
https://ift.tt/2GZ3e4q
From the development of an open-source energy modelling tool to its application and the creation of communities of practice: The example of OSeMOSYS
Gardumi, F; Shivakumar, A; Morrison, R; Taliotis, C; Broad, O; Beltramo, A; Sridharan, V; ... Alfstad, T; + view all Gardumi, F; Shivakumar, A; Morrison, R; Taliotis, C; Broad, O; Beltramo, A; Sridharan, V; Howells, M; Hörsch, J; Niet, T; Almulla, Y; Ramos, E; Burandt, T; Balderrama, GP; Moura, GNPD; Zepeda, E; Alfstad, T; - view fewer (2018) From the development of an open-source energy modelling tool to its application and the creation of communities of practice: The example of OSeMOSYS. Energy Strategy Reviews , 20 pp. 209-228. 10.1016/j.esr.2018.03.005 .
https://ift.tt/2IydvS6
AbDb: Antibody structure database - A database of PDB derived antibody structures
Ferdous, S; Martin, ACR; (2018) AbDb: Antibody structure database - A database of PDB derived antibody structures. Database : the Journal of Biological Databases and Curation (In press).
https://ift.tt/2GVbm67
Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis
Jacob, J; Odink, A; Brun, AL; Macaluso, C; de Lauretis, A; Kokosi, M; Desai, S; ... Wells, A; + view all Jacob, J; Odink, A; Brun, AL; Macaluso, C; de Lauretis, A; Kokosi, M; Desai, S; Devaraj, A; Renzoni, E; Wells, A; - view fewer (2018) Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis. Respiratory Medicine (In press).
https://ift.tt/2uTmZFK
The symbolic violence of setting: A Bourdieusian analysis of mixed methods data on secondary students' views about setting
Archer, L; Francis, B; Miller, S; Taylor, B; Tereschenko, A; Mazenod, A; Pepper, D; Archer, L; Francis, B; Miller, S; Taylor, B; Tereschenko, A; Mazenod, A; Pepper, D; Travers, M-C; - view fewer (2018) The symbolic violence of setting: A Bourdieusian analysis of mixed methods data on secondary students' views about setting. British Educational Research Journal , 44 (1) pp. 119-140. 10.1002/berj.3321 .
https://ift.tt/2q9qXFv
Different ventilation techniques and hemodynamic optimization to maintain regional cerebral oxygen saturation (rScO 2 ) during laparoscopic bariatric surgery: a prospective randomized interventional study
Abstract
Purpose
The purpose of this study was to assess the changes in regional cerebral oxygen saturation (rScO2) in response to different ventilation strategies: inspired oxygen concentration (FiO2), end-tidal carbon dioxide (EtCO2), and positive end expiratory pressure (PEEP) in addition to optimizing mean arterial pressure (MAP) in obese patients subjected to laparoscopic bariatric surgery in the reverse trendelenburg position.
Methods
50 obese patients were randomly assigned into one of two groups. Each group is 25 patients. Control patients subjected to a ventilation strategy aimed to maintain FiO2 0.4 and EtCO2 30 mmHg without PEEP. Study patients were assigned to specific protocol; T0, baseline rScO2; T1, 5 min following induction; T2, PP/RTP (10 min after pneumoperitoneum and reverse trendelenburg position); T3, PEEP 10 cmH2O; T4, FiO2 1.0; T5, EtCO2 40 mmHg and T6, MAP/BL; MAP back to baseline in both groups.
Main results
10 min after PP/RTP, there was a significant decrease in rScO2 in both groups. At T4, with FiO2 1.0, there was significant improvement in rScO2 when compared to T2. At T5, with EtCO2 40 mmHg, rScO2 significantly enhanced when compared to EtCO2 30 mmHg. At T4 and T5, we observed highly significance difference between both groups. At the end of the procedure and when MAP increased back to baseline (T6) in both groups, rScO2 statistically increased in both groups when compared to T2.
Conclusion
In obese patients, subjected to laparoscopic bariatric surgery in reverse trendelenburg position, adjustment of ventilation strategies and hemodynamic optimization succeeded to improve rScO2.
https://ift.tt/2IxY0cX
Development and worldwide use of non-lethal, and minimal population-level impact, protocols for the isolation of amphibian chytrid fungi
Fisher, M; Ghosh, P; Shelton, J; Bates, K; Brookes, L; Wierzbicki, C; Rosa, G; ... Garner, TWJ; + view all Fisher, M; Ghosh, P; Shelton, J; Bates, K; Brookes, L; Wierzbicki, C; Rosa, G; Farrer, R; Aanensen, D; Alvarado-Rybak, M; Bataille, A; Berger, L; Böll, S; Bosch, J; Clare, F; Courtois, E; Crottini, A; Cunningham, A; Doherty-Bone, T; Gebresenbet, F; Gower, D; Hoglund, J; James, T; Jenkinson, T; Kosch, T; Lambertini, C; Laurila, A; Lin, C-F; Loyau, A; Martel, A; Meurling, S; Miaud, C; Minting, P; Ndriantsoa, S; Pasmans, F; Rakotonanahary, T; Rabenmananjara, F; Ribeiro, L; Schmeller, D; Schmidt, B; Skerratt, L; Smith, F; Soto-Azat, C; Tessa, G; Felipe Toledo, L; Valenzuela-Sánchez, A; Verster, R; Voros, J; Waldman, B; Webb, R; Weldon, C; Wombwell, E; Zamudio, K; Longcore, J; Garner, TWJ; - view fewer (2018) Development and worldwide use of non-lethal, and minimal population-level impact, protocols for the isolation of amphibian chytrid fungi. Scientific Reports (In press).
https://ift.tt/2GXjqmG
Palaeoanthropology: The dawn of Homo floresiensis
Gomez-Robles, A; (2016) Palaeoanthropology: The dawn of Homo floresiensis. [Letter]. Nature , 534 (7606) pp. 188-189. 10.1038/534188a . Green open access
https://ift.tt/2IwXbkx
Age and Gender Differences in Social Network Composition and Social Support Among Older Rural South Africans: Findings From the HAALSI Study
Harling, G; Morris, KA; Manderson, L; Perkins, JM; Berkman, LF; (2018) Age and Gender Differences in Social Network Composition and Social Support Among Older Rural South Africans: Findings From the HAALSI Study. The Journals of Gerontology: Series B 10.1093/geronb/gby013 . (In press). Green open access
https://ift.tt/2H40W3Z
Predicting language outcomes after stroke: is structural disconnection a useful predictor?
Hope, TMH; Leff, AP; Price, C; (2018) Predicting language outcomes after stroke: is structural disconnection a useful predictor? NeuroImage: Clinical (In press).
https://ift.tt/2IxtQ9M
Applying Positive Psychology Principles to Soccer Interventions for People with Mental Health Difficulties
Friedrich, B; Mason, O; (2018) Applying Positive Psychology Principles to Soccer Interventions for People with Mental Health Difficulties. Psychology , 9 pp. 372-384. 10.4236/psych.2018.93023 . Green open access
https://ift.tt/2H4oZ2Z
Delivering cognitive behavioural therapy to advanced cancer patients: A qualitative exploration into therapists' experiences within a UK psychological service
Hassan, S; Bennett, K; Serfaty, M; (2018) Delivering cognitive behavioural therapy to advanced cancer patients: A qualitative exploration into therapists' experiences within a UK psychological service. Clinical Psychology & Psychotherapy 10.1002/cpp.2190 . (In press).
https://ift.tt/2uPqk8C
Repeated touch and needle prick stimulation in the neonatal period increases the baseline mechanical sensitivity and post-injury hypersensitivity of adult spinal sensory neurons
van den Hoogen, NJ; Patijn, J; Tibboel, D; Joosten, BA; Fitzgerald, M; Kwok, CH; (2018) Repeated touch and needle prick stimulation in the neonatal period increases the baseline mechanical sensitivity and post-injury hypersensitivity of adult spinal sensory neurons. Pain 10.1097/j.pain.0000000000001201 . (In press). Green open access
https://ift.tt/2GXTdEF
The effectiveness and cost-effectiveness of screening for latent tuberculosis among migrants in the EU/EEA: a systematic review
Zenner, D; (2018) The effectiveness and cost-effectiveness of screening for latent tuberculosis among migrants in the EU/EEA: a systematic review. Eurosurveillance , 23 (14) , Article pii=17-00543. 10.2807/1560-7917.ES.2018.23.14.17-00543 . Green open access
https://ift.tt/2uMJz2G
Efficacy and safety of intravitreal anti-tumour necrosis factor drugs in adults with non-infectious uveitis - a systematic review
Leal, I; Rodrigues, FB; Sousa, DC; Romão, VC; Duarte, GS; Carreño, E; Dick, AD; ... Fonseca, JE; + view all Leal, I; Rodrigues, FB; Sousa, DC; Romão, VC; Duarte, GS; Carreño, E; Dick, AD; Marques-Neves, C; Costa, J; Fonseca, JE; - view fewer (2018) Efficacy and safety of intravitreal anti-tumour necrosis factor drugs in adults with non-infectious uveitis - a systematic review. Acta Ophthalmologica 10.1111/aos.13699 . (In press).
https://ift.tt/2q7XYSm
The effectiveness and cost-effectiveness of screening for active tuberculosis among migrants in the EU/EEA: a systematic review
Zenner, D; (2018) The effectiveness and cost-effectiveness of screening for active tuberculosis among migrants in the EU/EEA: a systematic review. Eurosurveillance , 23 (14) , Article pii=17-00542. 10.2807/1560-7917.ES.2018.23.14.17-00542 . Green open access
https://ift.tt/2IylWx3
Corneal transplant follow-up study II (CTFS II): a prospective clinical trial to determine the influence of HLA class II matching on corneal transplant rejection: baseline donor and recipient characteristics
Armitage, WJ; Winton, HL; Jones, MNA; Crewe, JM; Rogers, CA; Tole, DM; Dick, AD; (2018) Corneal transplant follow-up study II (CTFS II): a prospective clinical trial to determine the influence of HLA class II matching on corneal transplant rejection: baseline donor and recipient characteristics. British Journal of Ophthalmology 10.1136/bjophthalmol-2017-311342 . (In press). Green open access
https://ift.tt/2H1bnoV
Introduction: Historical boom and bust--and the (British) Jewish question
Berkowitz, M; (2018) Introduction: Historical boom and bust--and the (British) Jewish question. Jewish Historical Studies: Transactions of the Jewish Historical Society of England 10.14324/111.444.JHS.2017.V49.041 . (In press).
https://ift.tt/2uM5A1u
Histories of Technology, the Environment and Modern Britain
Agar, JE and Ward, J (Eds). (2018) Histories of Technology, the Environment and Modern Britain. [Book]. UCL Press: London, UK. Green open access
https://ift.tt/2H4ZGNU
The freedom of the Etruscans: Etruria between Hellenization and Orientalization
Riva, C; (2018) The freedom of the Etruscans: Etruria between Hellenization and Orientalization. International Journal of the Classical Tradition 10.1007/s12138-018-0464-z . (In press).
https://ift.tt/2IwDYQ1
Responses of fishes and lampreys to the re-creation of meanders in a small English chalk stream
Champkin, JD; Copp, GH; Sayer, CD; Clilverd, HM; George, L; Vilizzi, L; Godard, MJ; ... Walker, AM; + view all Champkin, JD; Copp, GH; Sayer, CD; Clilverd, HM; George, L; Vilizzi, L; Godard, MJ; Clarke, J; Walker, AM; - view fewer (2017) Responses of fishes and lampreys to the re-creation of meanders in a small English chalk stream. River Research and Applications , 34 (1) pp. 34-43. 10.1002/rra.3216 .
https://ift.tt/2H0AsjO
Probabilistic approach for collision risk analysis of powered vessel with offshore platforms
Mujeeb-Ahmed, MP; Seo, JK; Paik, JK; (2018) Probabilistic approach for collision risk analysis of powered vessel with offshore platforms. Ocean Engineering , 151 pp. 206-221. 10.1016/j.oceaneng.2018.01.008 .
https://ift.tt/2uN5w1H
Universal stability curve for pattern formation in pulsed gas-solid fluidized beds of sandlike particles
de Martin, L; Ottevanger, C; van Ommen, JR; Coppens, M-O; (2018) Universal stability curve for pattern formation in pulsed gas-solid fluidized beds of sandlike particles. Physical Review Fluids , 3 (3) , Article 034303. 10.1103/PhysRevFluids.3.034303 . Green open access
https://ift.tt/2H4ZmyG
Measuring what matters MOST: Validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer (ROC)
King, MT; Stockler, M; O'Connell, R; Buizen, L; Joly, F; Lanceley, A; Hilpert, F; ... Friedlander, M; + view all King, MT; Stockler, M; O'Connell, R; Buizen, L; Joly, F; Lanceley, A; Hilpert, F; Okamato, A; AOTANI, E; Bryce, J; Donnellan, P; Oza, A; Avall-Lundquist, M; Berek, J; Feeney, A; Berton-Rigaud, D; Sehouli, J; Friedlander, M; - view fewer (2018) Measuring what matters MOST: Validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer (ROC). Quality of Life Research , 27 (1) pp. 59-74. 10.1007/s11136-017-1729-8 .
https://ift.tt/2uS8ou3
Islands of vulnerability and resilience: Manufactured stereotypes?
Kelman, I; (2018) Islands of vulnerability and resilience: Manufactured stereotypes? Area (In press).
https://ift.tt/2H0zWSU
ILC2s in infectious diseases and organ-specific fibrosis
Abstract
Type 2 immune responses evolved to provide host protection against parasitic infections and to support the repair of infection-induced tissue injury. However, persistent chronic organ damage can result in dysregulated production of critical type 2 cytokines supporting tissue remodeling and fibrosis development. Recently, group 2 innate lymphoid cells (ILC2s) were newly described as central innate mediators of type 2 responses. In particular, by secretion of the cytokines IL-5, IL-9, and IL-13 and the growth factor amphiregulin in response to the release of tissue-derived alarmins, ILC2s have been shown to substantially contribute to both the dismissal of metazoan parasites and the repair of infection-dependent or sterile tissue damage. Conversely, cytokine production by ILC2s emerged as a driving force for tissue remodeling and excessive fibrosis in several organ systems including the lung, liver, and skin. In this review, we discuss how ILC2s are specifically implicated in the body's immune response to different pathogenic infections and how dysregulated ILC2s may promote organ-specific fibrosis.
https://ift.tt/2uNwlTy
Utility of PET-CT in detecting nodal metastasis in cN0 early stage oral cavity squamous cell carcinoma
Source:Oral Oncology, Volume 80
Author(s): Han Zhang, Hadi Seikaly, Vincent L. Biron, Caroline C. Jeffery
BackgroundManagement of the clinically node-negative neck (cN0) in patients with early stage oral cavity squamous cell carcinoma (OCSCC) is challenging. Accurate imaging alternatives to elective neck dissections would help reduce surgical morbidity. While pooled studies suggest that imaging modalities have similar accuracy in predicting occult nodal disease, no study has examined the utility of PET-CT in this specific population of low-volume, clinically T1 and T2 OCSCC patients.MethodsA retrospective review of patients in the Alberta Cancer Registry who were diagnosed with cT1 or T2N0M0 OCSCC who underwent elective unilateral or bilateral neck dissections was performed. Pre-operative PET-CT and CT necks were reviewed for number of radiographically suspicious lymph nodes. Surgical pathology reports were reviewed to obtain the total number of nodes sampled and number of malignant nodes.ResultsBetween 2009 and 2013, 148 patients were diagnosed with cT1 or T2N0M0 OCSCC. Of these, 96 patients underwent elective neck dissections. All patients underwent preoperative CT of the neck with 32 patients having undergone additional preoperative PET-CT. Based on finally surgical pathology, the overall rate of occult metastasis was 13.5% (13/96). The overall sensitivity and specificity of PET-CT in this cohort was 21.4% and 98.4%, respectively with a negative predictive value of 99.1%. Although sensitivity improved in patients with tumors ≥2 cm and depth ≥4 mm, specificity remained unchanged.ConclusionIn patients with cT1 and T2N0 OCSCC, PET-CT has high negative predictive value. These patients can be considered for treatment with single modality surgical resection and elective neck dissection.
https://ift.tt/2GFSkwU
Asthma Across the Lifespan: Time for a Paradigm Shift
Publication date: Available online 5 April 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Stanley J. Szefler
We have a unique opportunity to significantly reduce the worldwide burden of asthma in children and impact respiratory outcomes in adults. However, this will require a paradigm shift that is directed at altering the natural history of asthma, reducing asthma exacerbations and preventing long-term adverse outcomes of childhood asthma. Attention should continue to be directed toward minimizing risk as well as impairment with a goal to achieve optimal control. Based on several NIH studies conducted over the last 10 years we now have the tools necessary to accomplish this goal. The tools include: assessment of lung function over time or defining trajectories of lung growth, the Composite Asthma Severity Score (CASI), a panel of useful biomarkers, the Seasonal Asthma Exacerbation Prediction Index (SAEPI), and rapidly advancing technology that includes adherence monitoring. Future guidelines revisions should consider incorporating recommendations to follow spirometry over time and defining trajectories of lung growth to assess risk for reduced lung growth and early decline, asthma burden, using biomarkers to select and monitor therapy, assessing social determinants of health, evaluating risk for seasonal exacerbations, and consideration of electronic adherence monitoring for asthma that is difficult to manage. Guidelines should continue to include a core dedicated to the diagnosis and treatment of intermittent and mild and moderate persistent asthma and include additional sections dedicated to the management of severe asthma.
https://ift.tt/2uQU0SL
A Jagged1-Notch4 Molecular Switch Mediates Airway Inflammation by Ultrafine Particles
Publication date: Available online 5 April 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Mingcan Xia, Hani Harb, Arian Saffari, Constantinos Sioutas, Talal A. Chatila
BackgroundExposure to traffic-related particulate matter (PM) promotes asthma and allergic diseases. However, the precise cellular and molecular mechanisms by which PM exposure acts to mediate these effects remain unclear.ObjectiveWe sought to elucidate the cellular targets and signaling pathways critical for the augmentation of allergic airway inflammation induced by ambient ultra fine particles (UFP).MethodsWe employed in vitro cell culture assays using lung-derived antigen presenting cells and allergen-specific T cells, and in vivo mouse models of allergic airway inflammation that employed myeloid lineage-specific gene deletions, cellular reconstitution approaches and antibody inhibition studies.ResultsWe identified lung alveolar macrophage (AM) as the key cellular target of UFP in promoting airway inflammation. Aryl hydrocarbon receptor (AhR)-dependent induction of Jagged 1 (Jag1) expression in AM was necessary and sufficient for the augmentation of allergic airway inflammation by UFP. UFP promoted Th2 and Th17 cell differentiation of allergen-specific T cells in a Jag1- and Notch4-dependent manner. Treatment of mice with an anti-Notch 4 antibody abrogated the exacerbation of allergic airway inflammation induced by UFP.ConclusionUFP exacerbate allergic airway inflammation by promoting a Jag1-Notch4-dependent interaction between Alveolar Macrophages and Allergen-Specific T cells, leading to augmented Th cell differentiation.
Graphical abstract
Teaser
Traffic related particulate matter induce the expression of Jagged1 on alveolar macrophages in an aryl hydrocabron receptor-dependent manner, which in turn interacts with Notch4 on Allergen-Specific T cells to promote allergic airway inflammation.https://ift.tt/2HcKID9
Viral induced overproduction of epithelial TSLP: Role in exacerbations of asthma and COPD?
Source:Journal of Allergy and Clinical Immunology
Author(s): Lena Uller, Carl Persson
https://ift.tt/2uQQNCJ
A rare case of a lingual mass in a neonate
Abstract
A large lingual cyst was noted on the 22-week antenatal ultrasound, which grew in proportion to the foetus on serial imaging. An elective c-section was performed in view of possible airway obstruction, and the neonate initially required oxygen to maintain saturations. Aged 1 month, the baby developed significant breastfeeding difficulties secondary to rapid cyst and secondary tongue enlargement, completely filling the oral cavity. Fifteen millilitres of fluid were aspirated in clinic, resulting in reduction of tongue size and immediate improvement in feeding. The patient subsequently underwent surgical excision of the cyst, which filled most of the anterior two-thirds of the tongue up to the foramen caecum. Histology supported the diagnosis of lingual thyroglossal duct cyst. A rare variant of thyroglossal duct cysts, these cysts can be potentially difficult to manage. More commonly located in the tongue base, we present an even rarer variant, that of an anterior tongue cyst.https://ift.tt/2HfSY5i
Obstructive hydrocephalus secondary to odontoid pannus: case report and review of literature
Abstract
Odontoid pannus or periodontoid pseudotumour is associated with a variety of rheumatological conditions. We report a case of an 80-year old man who presented with acute hydrocephalus following an emergency operation to amputate his infected left big toe. Imaging revealed a large tissue mass causing severe compression at the cervico-medullary junction and obstruction of CSF flow. The acute hydrocephalus was presumed to be related to neck manoeuvring during general anaesthesia. Following an initial emergency CSF diversion through external ventricular drainage catheter insertion, the patient subsequently underwent ventriculo-peritoneal insertion and posterior spinal decompression and fixation. To our knowledge, there have been no reported cases of tophaceous gout of the odontoid pannus causing acute hydrocephalus.https://ift.tt/2uQkaVZ
Two patients with spontaneous transomental hernia treated with laparoscopic surgery: a review
Abstract
Here, we report two patients with transomental hernia who were successfully treated with laparoscopic surgery. The first patient was a 58-year-old female who presented to our hospital with abdominal pain and vomiting; she had no history of abdominal surgery. Enhanced computed tomography revealed strangulation ileus due to an internal hernia. The second patient was a 36-year-old male who presented to our hospital with abdominal pain and no history of abdominal surgery. Enhanced computed tomography indicated transomental hernia. Emergency laparoscopic surgery in both patients revealed incarcerated bowel loops through defects in the greater omentum. The bowel segments were laparoscopically released, and the patients were uneventfully discharged on postoperative Days 4 and 8. Laparoscopic surgery is useful for the diagnosis and treatment of small bowel obstruction due to transomental hernia through the greater omentum.https://ift.tt/2HcKOe8
Giant anorectal condyloma acuminatum of Buschke–Löwenstein presents difficult management decisions
Abstract
Condyloma acuminata, or anogenital warts, caused by human papillomavirus are the most common sexually transmitted disease. In rare cases, the disease could progress to an extensive neoplasm called Buschke–Löwenstein tumor (BLT), also known as giant condyloma acuminatum. BLT differs from normal condyloma acuminata by presenting with locally invasive growth, lack of spontaneous resolution, tendency for recurrence after treatment and potential for malignant transformation. We examine a BLT case reaching large dimensions in the anorectal region treated with neoadjuvant chemoradiation therapy and surgical excision of residual lesions. Furthermore, continuous follow-up care can help identify and prevent recurrence or malignant transformation of the tumor.https://ift.tt/2Epmnab
Laparoscopic approach to non-communicating intestinal duplication cyst in adult
Abstract
Intestinal duplication is rare congenital pathology generally diagnosed in infancy or early childhood. Presentation in adults is extremely rare. We present a case of a 36-year-old otherwise healthy female patient without any past medical history. She presented with a month of lower abdominal pain, clinical examination revealed pain and a palpable mass in the lower abdomen. CT scan confirmed a cystic mass dependent of the cecum wall and colonoscopy showed an extrinsic compression of the lateral wall of the ascending colon. However, the mucosa and the rest of the colon appeared normal. Since pain became more intense laparoscopy was performed and a cystic mass dependent on the cecum was discovered. Laparoscopic hemicolectomy was performed. Patient underwent full recovery. On follow up controls, pathology described intestinal cystic duplication of the colonic wall.https://ift.tt/2HfSV9C
Mitral valve replacement for Libman–Sacks endocarditis in a patient with antiphospholipid syndrome secondary to systemic lupus erythematosus
Abstract
Libman–Sacks endocarditis is a relatively rare sterile verrucous vegetative lesion observed in systemic lupus erythematosus (SLE)/antiphospholipid syndrome (APLS) patients. Most patients with this condition are asymptomatic. Here we report a case of a 46-year-old woman with APLS secondary to SLE complicated with frequent thromboembolic events due to a mitral valve mass. We performed minimally invasive mitral valve replacement with a mechanical prosthetic valve, and she was successfully discharged 14 days after surgery. Thus, Libman–Sacks endocarditis may be an indication for mitral valve replacement.https://ift.tt/2EmjtD7
Inguinal hernia causing extrinsic compression of bilateral ureters leading to chronic obstructive uropathy
Abstract
Ureteral inguinal hernias are a well-documented cause of obstructive uropathy with ureteric involvement in the hernia sac. In this unique case, the left-sided inguinal hernia causes extrinsic compression of bilateral ureters outside of the hernia sac leading to chronic obstructive uropathy, which is demonstrated on non-contrast CT and cystogram. This patient was managed with nephrostomy and subsequently antegrade stenting with nephrostomy removal. Prior to nephrostomy removal, nephrostogram demonstrated tapering of the left ureter in the pelvis. The patient's renal function continues to improve and is awaiting repair if his inguinal hernia after which he will have his ureteric stent removed.https://ift.tt/2HfT9gY
Massive chronic irreducible rectal prolapse successfully treated with Altemeier’s procedure
Abstract
The guideline for the treatment of rectal prolapse recommends that surgeons select appropriate surgical procedures individually based on each patient's overall status. However, in cases of irreducible or incarcerated rectal prolapse, surgical options are quite limited. Here we present a case of an elderly woman with massive chronic irreducible rectal prolapse. An 87-year-old woman presented to our hospital with a complaint of massive rectal prolapse. The prolapsed rectum was over 20 cm long, and completely irreducible. She underwent perineal rectosigmoidectomy with levatorplasty known as Altemeier's procedure. More than 30 cm of rectosigmoid colon was resected. After the operation, rectal prolapse was resolved completely. Her postoperative course was uneventful, and her quality of life and bowel movements improved. She has since been healthy without recurrence for over 2 years. Altemeier's procedure is applicable even in cases of irreducible rectal prolapse and features acceptable safety and a satisfactory outcome.https://ift.tt/2Eoq9kt
Abdominal wall extra-adrenal myelolipoma, a case report and review of the literature
Abstract
Extra-adrenal myelolipomas (EAMLs) are extremely rare soft tissue tumours that constitute <15% of all myelolipomas. We present a 70-year-old patient with a midline swelling of the anterior abdominal wall. It was clinically diagnosed as an incisional hernia, though the computerized scan indicated an internal hernia. During laparoscopy a soft tissue tumour of the abdominal wall was identified and excised. Pathology confirmed an extra-adrenal myelolipoma of the anterior abdominal wall through the presence of adipocytes and trilineage haematopoetic cell lines. EAMLs are rare mesenchymal soft tissue tumours with less than a hundred cases reported in the English literature. Pathological diagnosis shows the presence of mature adipocytes as well as myeloid and erythroid cell lines. This is the first case report of an EAML of the anterior abdominal wall. This case report is made even more rare as it is present in a male patient.https://ift.tt/2HfSPig
Paraganglioma or pheochromocytoma? A peculiar diagnosis
Abstract
Paragangliomas and pheochromocytomas are rare catecholamine secreting neoplasms that arise in the extra-adrenal autonomic paraganglia and adrenal medulla, respectively. Although typically presenting with paroxysms of headaches, palpitations, diaphoresis and hypertension, a broad spectrum of clinical manifestations may occur. Diagnosis relies on biochemical studies followed by adequate imaging investigation. Cross sectional morphological and functional imaging modalities have improved diagnostic accuracy and are crucial in the surgical planning. The authors report on a case of a 64-year-old female that presented with severe hypertension, palpitations and fatigue as the manifestations of a catecholamine secreting neoplasm. Abdominal contrast enhanced computer tomography revealed a right sided 78 mm adrenal medullary tumor suggestive of a pheochromocytoma. Standard therapeutical strategies were initially unsuccessful, and additional investigation and therapy were required to cure the patient. The challenges faced by the multidisciplinary team in the pre-operative evaluation, medical management and surgical treatment are reported.https://ift.tt/2uQ3ZYH
CGRP Monoclonal Antibodies for the Preventative Treatment of Migraine
Abstract
Purpose of Review
CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have been developed and are currently under investigation for episodic (EM) and chronic migraine (CM) prevention. Here, we report data from these clinical trials.
Recent Findings
Placebo-controlled, randomized double-blind phase studies of CGRP mAbs in episodic and chronic migraine have shown that the specific blockade of the peptide or the CGRP receptor are both powerful mechanisms to reduce migraine frequency. Along with the reduction of acute migraine-specific medication intake, early onset of efficacy of mAbs has been demonstrated. Most common adverse events are injection sider reactions. Depending on the mAb, the administration mode is a monthly or even less frequently s.c. or I.V. formulation.
Summary
Phase II studies in EM and CM demonstrate that CGRP mAbs are effective anti-migraine preventatives with a beneficial adverse event profile. Further detailed results from larger phase III clinical trials are expected soon.
https://ift.tt/2qbDCad
Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review
Abstract
Purpose
To improve the diagnoses of the salivary gland tumors, a dynamic-enhanced MRI (dMRI) was investigated.
Methods
We conducted a retrospective chart review of 93 cases of salivary gland tumors. The histological diagnoses were obtained from all patients using a surgical specimen and/or an open biopsy specimen. The dMRI as well as fine-needle aspiration cytology (FNAC) and intraoperative frozen section (IFS) were analyzed. This study focused on the time-intensity curve (TIC) after injection, peak time (Tpeak), washout ratio (WR) as well as the gradient of enhancement and washout profile.
Results
The histological diagnoses included pleomorphic adenoma (PMA) in 53 cases, the Warthin tumors (WT) in 14 cases and malignant tumors (MT) in 26 cases. Incorrect diagnosis rate of FNAC and IFS were 5.2 and 8.3%, respectively. The TIC revealed differences among the three types of tumors. Tpeak as well as WR also revealed significant differences (p < 0.001). Tpeak were lower in order of WT, MT, PMA, respectively. WR of TICs at 30, 45 and 105 s after Tpeak were higher in order of WT, MT, PMA, respectively (p < 0.001). The gradient of increment and washout in the TIC curve was also an important parameter to distinguish the three types of tumors. In MT, the rapid enhancement pattern was found in high or intermediate histological grade tumors, whereas the slow enhancement pattern was exhibited in low grade tumors.
Conclusions
Our findings indicate that using Tpeak and WR, it is possible to distinguish between WT, PMA and MT. Additionally, a rapid enhancement pattern may be a potential marker for these tumors.
https://ift.tt/2JoWOKq
Detection of Beak and feather disease virus in native and introduced parrots and consequent implications for conservation and the pet bird trade
Fogell, DJ; Martin, RO; Bunbury, N; Lawson, B; Sells, J; McKeand, AM; Tatayah, V; ... Groombridge, JJ; + view all Fogell, DJ; Martin, RO; Bunbury, N; Lawson, B; Sells, J; McKeand, AM; Tatayah, V; Trung, CT; Groombridge, JJ; - view fewer (2018) Detection of Beak and feather disease virus in native and introduced parrots and consequent implications for conservation and the pet bird trade. Conservation Biology (In press).
https://ift.tt/2EoCiFQ
The future-gazing potential of digital personalisation in young children’s reading: views from education professionals and app designers
Kucirkova, N; Flewitt, R; (2018) The future-gazing potential of digital personalisation in young children's reading: views from education professionals and app designers. Early Child Development and Care (In press).
https://ift.tt/2GYZVKk
British Neuropathological Society and International Society of Forensic Radiology and Imaging Expert Consensus Statement for Post-mortem Neurological Imaging
Shelmerdine, SC; Hutchinson, JC; Al-Sarraj, S; Cary, N; Dawson, T; Plessis, DD; Ince, PG; ... International Society of Forensic Radiology and Imaging, .; + view all Shelmerdine, SC; Hutchinson, JC; Al-Sarraj, S; Cary, N; Dawson, T; Plessis, DD; Ince, PG; McLaughlin, S; Palm, L; Smith, C; Stoodley, N; van Rijn, R; Arthurs, OJ; Jacques, TS; British Neuropathological Society, .; International Society of Forensic Radiology and Imaging, .; - view fewer (2018) British Neuropathological Society and International Society of Forensic Radiology and Imaging Expert Consensus Statement for Post-mortem Neurological Imaging. Neuropathology and Applied Neurobiology 10.1111/nan.12482 . (In press).
https://ift.tt/2GCI3l7
COPD as a Risk Factor for Cardiovascular Disease: A View from the SUMMIT
Hurst, JR; Sin, DD; (2018) COPD as a Risk Factor for Cardiovascular Disease: A View from the SUMMIT. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201802-0347ED . (In press). Green open access
https://ift.tt/2Jpn1s8
Imaging complex ventral hernias, their surgical repair, and their complications
Halligan, S; Parker, SG; Plumb, AA; Windsor, ACJ; (2018) Imaging complex ventral hernias, their surgical repair, and their complications. European Radiology 10.1007/s00330-018-5328-z . (In press). Green open access
https://ift.tt/2Eo97mx
Cutting Materials in Half: A Graph Theory Approach for Generating Crystal Surfaces and Its Prediction of 2D Zeolites
Witman, M; Ling, S; Boyd, P; Barthel, S; Haranczyk, M; Slater, B; Smit, B; (2018) Cutting Materials in Half: A Graph Theory Approach for Generating Crystal Surfaces and Its Prediction of 2D Zeolites. ACS Central Science , 4 (2) pp. 235-245. 10.1021/acscentsci.7b00555 . Green open access
https://ift.tt/2JprfQo
Dissimilarity for functional data clustering based on smoothing parameter commutation
Tzeng, S; Hennig, C; Li, Y-F; Lin, C-J; (2018) Dissimilarity for functional data clustering based on smoothing parameter commutation. Statistical Methods in Medical Research 10.1177/0962280217710050 . (In press). Green open access
https://ift.tt/2ElieUV
Housing privatization and the return of the state: changing governance in China
Wu, F; (2018) Housing privatization and the return of the state: changing governance in China. Urban Geography 10.1080/02723638.2018.1440126 . (In press). Green open access
https://ift.tt/2H09CZ7
What are the factors that contribute to road accidents? An assessment of law enforcement views, ordinary drivers' opinions, and road accident records
Rolison, JJ; Regev, S; Moutari, S; Feeney, A; (2018) What are the factors that contribute to road accidents? An assessment of law enforcement views, ordinary drivers' opinions, and road accident records. Accident Analysis & Prevention , 115 pp. 11-24. 10.1016/j.aap.2018.02.025 . Green open access
https://ift.tt/2GFsCc6
The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial
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Propagation of Beta/Gamma Rhythms in the Cortico-Basal Ganglia Circuits of the Parkinsonian Rat
West, TO; Berthouze, L; Halliday, DM; Litvak, V; Sharott, A; Magill, PJ; Farmer, SF; (2018) Propagation of Beta/Gamma Rhythms in the Cortico-Basal Ganglia Circuits of the Parkinsonian Rat. Journal of Neurophysiology 10.1152/jn.00629.2017 . (In press). Green open access
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Bulbous Bows for Energy Efficient Ships: A Novel Approach
Grech La Rosa, A; Thomas, G; Muk-Pavic, E; Dinham-Peren, T; (2015) Bulbous Bows for Energy Efficient Ships: A Novel Approach. In: Energy Efficient Ships 2015. RINA: London.
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Antimicrobial activity of tellurium-loaded polymeric fiber meshes
Matharu, RK; Charani, Z; Ciric, L; Illangakoon, UE; Edirisinghe, M; (2018) Antimicrobial activity of tellurium-loaded polymeric fiber meshes. Journal of Applied Polymer Science 10.1002/app.46368 . (In press). Green open access
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Educational technology: revolutionizing surgical education
DeLacy, FB; Nehme, J; Lacy, AM; Chand, M; (2017) Educational technology: revolutionizing surgical education. British Journal of Hospital Medicine , 78 (8) pp. 426-427. 10.12968/hmed.2017.78.8.426 . Green open access
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The United Kingdom Primary Immune Deficiency (UKPID) Registry 2012 to 2017
Shillitoe, B; Bangs, C; Guzman, D; Gennery, AR; Longhurst, HJ; Slatter, M; Edgar, DM; ... Buckland, M; + view all Shillitoe, B; Bangs, C; Guzman, D; Gennery, AR; Longhurst, HJ; Slatter, M; Edgar, DM; Thomas, M; Worth, A; Huissoon, A; Arkwright, PD; Jolles, S; Bourne, H; Alachkar, H; Savic, S; Kumararatne, DS; Patel, S; Baxendale, H; Noorani, S; Yong, PFK; Waruiru, C; Pavaladurai, V; Kelleher, P; Herriot, R; Bernatonienne, J; Bhole, M; Steele, C; Hayman, G; Richter, A; Gompels, M; Chopra, C; Garcez, T; Buckland, M; - view fewer (2018) The United Kingdom Primary Immune Deficiency (UKPID) Registry 2012 to 2017. Clinical and Experimental Immunology 10.1111/cei.13125 . (In press).
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