Αρχειοθήκη ιστολογίου

Σάββατο 5 Μαΐου 2018

Assessing the International Landscape of Cancer Research through Successful Partnership

On April 11th, 2018 the NCI Center for Research Strategy, in coordination with CGH, hosted the Annual Meeting of the International Cancer Research Partnership (ICRP). The meeting marked 18 years of a successful partnership, representing 124 organizations that fund cancer research projects in 145 countries.



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Measuring Knowledge of Disease Management in Adolescents with Cystic Fibrosis: Initial Psychometric Evaluation

Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.


https://ift.tt/2wgaJQj

Philosophy of Management Between Scientism and Technology

Abstract

This article addresses the difficulty in pursuing a philosophical engagement with management without falling into the trap of scientism. It also explores the option to turn management theorists away from science to seek insights from technology. The article is organized in four parts: a preliminary discussion on management from a philosophical viewpoint, a crucial distinction between philosophy of management as a mode of inquiry and a field of study, an analysis of the risk of scientism in the current philosophical work on management, and an initial inspection across the waters separating management and philosophy of technology.



https://ift.tt/2r56KAi

Doing Away with the Agential Bias: Agency and Patiency in Health Monitoring Applications

Abstract

Mobile health devices pose novel questions at the intersection of philosophy and technology. Many such applications not only collect sensitive data, but also aim at persuading users to change their lifestyle for the better. A major concern is that persuasion is paternalistic as it intentionally aims at changing the agent's actions, chipping away at their autonomy. This worry roots in the philosophical conviction that perhaps the most salient feature of living autonomous lives is displayed via agency as opposed to patiency—our lives go well in virtue of what we do, rather than what happens to us. Being persuaded by a device telling us how to conduct our lives seemingly renders the agent passive, an inert recipient of technological commands. This agential bias, however, has led to a marginalization of patiential characteristics that are just as much part of our lives as are agential characteristics. To appreciate the inherent interlocking of acting and being acted upon, it is vital to acknowledge that agency and patiency are correlates, not mutually exclusive opposites. Furthermore, it is unclear whether an action can only count as agential so long as its causes are internal. Drawing on the extended mind and extended will framework, I argue that mHealth applications merely serve as volitional aids to the agent's internal cognition. Autonomously set goals can be achieved more effectively via technology. To be persuaded by an mHealth device does not mainly—let alone exclusively—emphasize patiency; on the contrary, it can be an effective tool for technologically enhancing agency.



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How Stone Tools Shaped Us: Post-Phenomenology and Material Engagement Theory

Abstract

The domain of early hominin stone tool making and tool using abilities has received little scholarly attention in mainstream philosophy of technology. This is despite the fact that archeological evidence of stone tools is widely seen today as a crucial source of information about the evolution of human cognition. There is a considerable archeological literature on the cognitive dimensions of specific hominin technical activities. However, within archeology and the study of human evolution the standard perception is stone tools are mere products of the human mind (or brain or innate cognitive capacities). A number of recent approaches to cognition challenges this simplistic one-way-causal-arrow view and emphasizes instead the functional efficiency of tools or artifacts in transforming and augmenting human (or hominin) cognitive capacities. As a result, the very idea that tools or artifacts are intimately tied to human cognitive processes is fast becoming an alternative within the cognitive sciences and a few allied disciplines. The present study intends to explore its implications for philosophy of technology. The central objective of this paper is to examine the dynamic and intricate tool-mediated activities of the early hominins through the lens of Don Ihde's post-phenomenological theory of human-technology relations and Lambros Malafouris' Material Engagement Theory. Highlighting the key points where these two research approaches, despite their subtle nuances, converge and look capable of mutually catalyzing each other, the paper attempts to show why it is important to bring these approaches together for a more refined understanding of the controversial role these stone tools played in human evolution.



https://ift.tt/2qQVVCs

Technological Environmentality: Conceptualizing Technology as a Mediating Milieu

Abstract

After several technological revolutions in which technologies became ever more present in our daily lives, the digital technologies that are currently being developed are actually fading away from sight. Information and Communication Technologies (ICTs) are not only embedded in devices that we explicitly "use" but increasingly become an intrinsic part of the material environment in which we live. How to conceptualize the role of these new technological environments in human existence? And how to anticipate the ways in which these technologies will mediate our everyday lives? In order to answer these questions, we draw on two approaches that each offers a framework to conceptualize these new technological environments: Postphenomenology and Material Engagement Theory. As we will show, each on their own, these approaches fail to do justice to the new environmental role of technology and its implications for human existence. But by bringing together Postphenomenology's account of technological mediation and Material Engagement Theory's account of engaging with environments, it becomes possible to sufficiently account for the new environmental workings of technology. To do justice to these new workings of environmental technologies, we introduce and develop the concept of "Technological Environmentality."



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Shaping a universally broad antibody response to influenza amidst a variable immunoglobulin landscape

Sarah F Andrews | Adrian B McDermott

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Influenza vaccines: ‘tailor-made’ or ‘one fits all’

Giulietta Saletti | Thomas Gerlach | Guus F Rimmelzwaan

https://ift.tt/2HYSL6l

Immune evasion of the CD1d/NKT cell axis

Randy R Brutkiewicz | Laura Yunes-Medina | Jianyun Liu

https://ift.tt/2HXvphm

FDA approves new uses for two drugs administered together for the treatment of BRAF-positive anaplastic thyroid cancer

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The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive). Read the FDA's press release for more information.

The post FDA approves new uses for two drugs administered together for the treatment of BRAF-positive anaplastic thyroid cancer appeared first on American Thyroid Association.



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Epidemiology of epistaxis in the emergency department of a southern European tertiary care hospital

Publication date: Available online 5 May 2018
Source:Acta Otorrinolaringológica Española
Author(s): Luis Roque Reis, Filipe Correia, Luis Castelhano, Pedro Escada
ObjectiveEpistaxis is the most common rhinological emergency seen in the emergency department. The purpose of this study was to evaluate epidemiological data of epistaxis in a southern European tertiary care hospital.MethodsA retrospective study was conducted during the period between January 2009 and December 2015. We analyzed the distribution by cross-referencing the demographic variables, destination after medical discharge, inpatient characteristics (major comorbid diseases, medication, bleeding localization and treatment) and health-care costs with the disease.ResultsEpistaxis accounted for approximately 1 in 30 visits to the ED and 77 out of a population of 100,000 was served by that ED. Overall, 71,624 patients were treated and 2371 patients presented with epistaxis (3.31%). One-thousand three-hundred and twenty-seven cases were male and 1044 female (p <.001). The mean age was 56 years (±26). Age distribution was bimodal, with peaks among those <10 years and >70 (p <.001). Epistaxis was more common in the winter months (p < 0.001). The main referral destinations (6.8%) included outpatient (2.9%) and inpatient (1.9%) services. Hospitalization was more frequent between the ages of 60 and 80 years (p =.029), and the major comorbidity was hypertension (47.8%). Medication interfering with haemostasis was documented in 30.4%. Most inpatient epistaxis was managed in a non-interventional manner and only. 5% of patients needed surgery. The mean total health-care cost was 69.8 € per episode.ConclusionEmergency epistaxis was more frequent in men, the elderly, patients with underlying comorbidities, during the winter months, and showed a higher risk of referral and hospitalization with increasing age (as a result of an aging population in western countries). The main hospital expenses for epistaxis are related to hospitalization and health care costs.



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Selective Neck Dissection Technique in the Treatment of Recurrent Pyriform Sinus Fistula

Abstract

The 3rd and 4th branchial arch fistulas are rare conditions which are due to embryological persistence or incomplete developmental anomalies. They have a typical course as described by the embryological development but the presentation of cases with true course as per embryology is rare. These patients usually present with repeated infections, inadequate surgical interventions and recurrences. We present two index cases of 3rd and 4th pyriform sinus fistulas with their varied anatomical course and clinical presentation who were treated by selective neck dissection technique.



https://ift.tt/2JTzvrk

Selective Neck Dissection Technique in the Treatment of Recurrent Pyriform Sinus Fistula

Abstract

The 3rd and 4th branchial arch fistulas are rare conditions which are due to embryological persistence or incomplete developmental anomalies. They have a typical course as described by the embryological development but the presentation of cases with true course as per embryology is rare. These patients usually present with repeated infections, inadequate surgical interventions and recurrences. We present two index cases of 3rd and 4th pyriform sinus fistulas with their varied anatomical course and clinical presentation who were treated by selective neck dissection technique.



https://ift.tt/2JTzvrk

Multicentric Castleman’s disease in human immunodeficiency virus infection: two case reports

Castleman's Disease is a rare B-cell lymphoproliferative disease. It is mostly benign and is characterized by non-neoplastic lymph node hypertrophy, associated with infection by human herpesvirus-8 in people w...

https://ift.tt/2HRY4IO

Outcome of Septorhinoplasty in Deviated Nose Deformity: One Year Cross-Sectional Study

Abstract

To evaluate outcome of Septorhinoplasty in Deviated nose deformity using Nasal Obstruction Symptom Evaluation (NOSE) scale and Rhinoplasty outcome evaluation score (ROE). This observational study was conducted in the department of Otorhinolaryngology and Head and Neck Surgery of KLE University's Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and Medical Research Center, Belagavi from January 2015 to December 2015. Forty patients were evaluated and comparisons were made for NOSE score preoperatively and postoperatively. Comparison of decrease in NOSE score with age distribution, sex distribution, type of septorhinoplasty, ROE score of patients and ROE score of surgeons were also made. ROE score of patients and ROE score of surgeons were correlated. Their statistical significance (p value) and Cohen's kappa (k) were calculated. Out of 40 patients, there were total of 16 Open Septorhinoplasty cases and 24 Close septorhinoplasty cases. NOSE score preoperatively and postoperatively showed statistically significant i.e., total score (p = 0.001). ROE score of patients and surgeons had poor correlation (k = 0.1; p = 0.2). Decrease in NOSE score postoperatively with ROE score of patients showed statistically significant (p = 0.01). There was no significance on comparison of decrease in NOSE score postoperatively with ROE score of surgeons (p = 0.09), age distribution (p = 0.1), sex distribution (p = 0.2) and septorhinoplasty (open/close) (p = 0.2). The outcome of septorhinoplasty has been validated with NOSE scale and ROE score and has been proven that there is improvement in nasal obstruction and quality of life after septorhinoplasty. The quality of life scoring is essential for patients subjected to septorhinoplasty for assessing success of the surgery.



https://ift.tt/2KD57Tl

Outcome of Septorhinoplasty in Deviated Nose Deformity: One Year Cross-Sectional Study

Abstract

To evaluate outcome of Septorhinoplasty in Deviated nose deformity using Nasal Obstruction Symptom Evaluation (NOSE) scale and Rhinoplasty outcome evaluation score (ROE). This observational study was conducted in the department of Otorhinolaryngology and Head and Neck Surgery of KLE University's Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and Medical Research Center, Belagavi from January 2015 to December 2015. Forty patients were evaluated and comparisons were made for NOSE score preoperatively and postoperatively. Comparison of decrease in NOSE score with age distribution, sex distribution, type of septorhinoplasty, ROE score of patients and ROE score of surgeons were also made. ROE score of patients and ROE score of surgeons were correlated. Their statistical significance (p value) and Cohen's kappa (k) were calculated. Out of 40 patients, there were total of 16 Open Septorhinoplasty cases and 24 Close septorhinoplasty cases. NOSE score preoperatively and postoperatively showed statistically significant i.e., total score (p = 0.001). ROE score of patients and surgeons had poor correlation (k = 0.1; p = 0.2). Decrease in NOSE score postoperatively with ROE score of patients showed statistically significant (p = 0.01). There was no significance on comparison of decrease in NOSE score postoperatively with ROE score of surgeons (p = 0.09), age distribution (p = 0.1), sex distribution (p = 0.2) and septorhinoplasty (open/close) (p = 0.2). The outcome of septorhinoplasty has been validated with NOSE scale and ROE score and has been proven that there is improvement in nasal obstruction and quality of life after septorhinoplasty. The quality of life scoring is essential for patients subjected to septorhinoplasty for assessing success of the surgery.



https://ift.tt/2KD57Tl

The characteristics and clinical significance of REM<10% in children with sleep-disordered breathing

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Publication date: July 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 110
Author(s): Liqiang Yang, Zhenyun Huang, Jianwen Zhong, Shuyao Qiu, Dabo Liu
ObjectiveFractional time in REM sleep <20% ('little REM sleep') is indicative of more severe sleep-disordered breathing (SDB) in adults. We examined if other REM% is predictive of more severe SDB in children.MethodsIn this retrospective study of 616 pediatric SDB patients, age, sex ratio, BMI, sleep efficiency, awakening frequency, sleep latency, apnea-hypopnea index (AHI), obstructive apnea index (OAI), and lowest oxygen pulse saturation (LSpO2) were compared among groups stratified according to REM%: REM≥20%, REM<20%, 15% ≤ REM<20%, 10% ≤ REM<15%, and REM<10%. Correlations with AHI, OAI, LSpO2, sleep efficiency, and awakening frequency were examined in REM<20% and REM<10% groups. Associations of these parameters with REM<10% were examined by single- and multifactor regression.ResultsPediatric SDB patients with little REM sleep demonstrated poorer sleep quality than patients with REM≥20%, while patients with REM<10% also exhibited more severe SDB. Specifically, the REM<20% group exhibited higher number of awakenings and lower sleep efficiency than the REM≥20% group (both P ≤ 0.001), as did each REM%<20% subgroup (lower sleep efficiency: all P < 0.05; higher awakening frequency: all P < 0.001). Moreover, compared to the REM≥20% group, the REM<10% also exhibited higher AHI (P = 0.025) and lower LSpO2 (P = 0.019). In the REM<10% group, individual REM% was negatively correlated with AHI (r = −0.216, P = 0.031) and positively with LSpO2 (r = 0.2, P = 0.046). Multifactor logistic regression correcting for age and BMI identified AHI as an independent predictor of REM<10% (P = 0.012, OR = 1.016, 95% CI [1.004,1.029]).ConclusionREM% <10% is associated with poor sleep quality and SDB severity in children, suggesting that this threshold should define "little REM sleep" in pediatric patients.



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Diagnostic Evaluation of Chronic Nasal Obstruction Based on Nasal Endoscopy and CT Scan Paranasal Sinus

Abstract

Evaluation of the accuracy of objective diagnostic modalities for nasal obstruction and their comparison to each other to reach the correct diagnosis with minimum cost and highest accuracy. This study was conducted in the Department of Otorhinolaryngology and Head Neck Surgery, Chirayu Medical College and Hospital, Bhopal from August 2016 to September 2017. A total of 50 patients from age group 1–70 years irrespective of sex with complaints of chronic nasal obstruction, which were unresponsive to routine appropriate medical therapy, were selected for this study. Comparative study among findings of nasal endoscopy and CT scan of the paranasal sinuses done. After clinical examination, patients were subjected to high resolution computed tomography (HRCT) of paranasal sinuses and diagnostic nasal endoscopy (DNE). The diagnostic results of both modalities were compared. The most common symptoms were nasal obstruction and nasal discharge 100%, followed by post nasal drip 62%. The complaints related to eye and ears were less frequent, found in 4% only. CRS (Chronic Rhinosinusitis) was most common pathology of nose for nasal obstruction which is in 72% cases. Sinonasal polyp is present in 20% of cases. Inverted papilloma in 4% cases. Granulomatous disease (Rhinosporidiosis) in 2% cases. Malignancy in 2% cases. In this series of 50 cases, nasal endoscopy revealed various pathological abnormalities mainly in the osteomeatal area. These include mucopurulent discharge in middle meatus seen in 100% of cases (50 patients). This could not be revealed in HRCT. Oedematous and polypoid infundibular mucosa/polyp in nasal cavity in 28% cases (14 patients) where it was not diagnosed in HRCT in three patients. Hence DNE proved superior to HRCT. Other abnormalities detected on nasal endoscopy were septal deviation 80% of cases (40 patients), inferior turbinate hypertrophy 66% of cases (33 patients), middle turbinate hypertrophy/concha bullosa in 48% of cases (24 patients). DNS was diagnosed in 42 patients in HRCT other causes of nasal obstruction such as Agar nasi cell is detected in 16% (8 patients), medialised uncinate process in 16% (8 patients), paradoxical MT in 30% cases were diagnosed more accurately in nasal endoscopy than HRCT. So nasal endoscopy proved better than CT scan. Nasal obstruction is the most common presenting complaint in day to day otolaryngology practice. Nobody would disagree with the role of CT scan and diagnostic nasal endoscopy in diagnosing the nasal and paranasal pathologies. But as a treating physician we are always concerned about early diagnosis and cost effectiveness. At the same time we also have to consider about patient waiting and work load. In this study we attempted to find out whether diagnostic nasal endoscopy can be better then CT scan, so that we can treat our patient appropriately. Though there has been an increased demand for imaging the paranasal sinuses with coronal CT because of functional endoscopic sinus surgery, nasal endoscopy is a better option in diagnosing and assessing the extent of disease and anatomy.



https://ift.tt/2HREGLZ

Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma—a feasibility study using full slide staining

Abstract

Diffuse large B-cell lymphoma (DLBCL) is subdivided by gene expression analysis (GEP) into two molecular subtypes named germinal center B-cell-like (GCB) and activated B-cell-like (ABC) after their putative cell-of-origin (COO). Determination of the COO is considered mandatory in any new-diagnosed DLBCL, not otherwise specified according to the updated WHO classification. Despite the fact that pathologists are free to choose the method for COO classification, immunohistochemical (IHC) assays are most widely used. However, to the best of our knowledge, no round-robin test to evaluate the interlaboratory variability has been published so far. Eight hematopathology laboratories participated in an interlaboratory test for COO classification of 10 DLBCL tumors using the IHC classifier comprising the expression of CD10, BCL6, and MUM1 (so-called Hans classifier). The results were compared with GEP for COO signature and, in a subset, with results obtained by image analysis. In 7/10 cases (70%), at least seven laboratories assigned a given case to the same COO subtype (one center assessed one sample as not analyzable), which was in agreement with the COO subtype determined by GEP. The results in 3/10 cases (30%) revealed discrepancies between centers and/or between IHC and GEP subtype. Whereas the CD10 staining results were highly reproducible, staining for MUM1 was inconsistent in 50% and for BCL6 in 40% of cases. Image analysis of 16 slides stained for BCL6 (N = 8) and MUM1 (N = 8) of the two cases with the highest disagreement in COO classification were in line with the score of the pathologists in 14/16 stainings analyzed (87.5%). This study describes the first round-robin test for COO subtyping in DLBCL using IHC and demonstrates that COO classification using the Hans classifier yields consistent results among experienced hematopathologists, even when variable staining protocols are used. Data from this small feasibility study need to be validated in larger cohorts.



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Reliability and validity of the Japanese translation of the DN4 Diagnostic Questionnaire in patients with neuropathic pain

Abstract

Background

The Douleur Neuropathique 4 questionnaire (DN4) is a simple and objective tool developed by the French Neuropathic Pain Group to screen for neuropathic pain.

Methods

This prospective observational study was undertaken in three hospitals to assess the validity of a Japanese translation of the DN4. We first translated the DN4 into Japanese using a forward–backward method. Pain specialists then examined patients independently and diagnosed them with neuropathic or non-neuropathic pain, according to the International Association for the Study of Pain definitions. The Japanese version of the DN4 questionnaire was then given to each patient.

Results

Of 187 patients that met our inclusion criteria, 100 and 87 were diagnosed with neuropathic and non-neuropathic pain, respectively. The test–retest intra-class correlation coefficient (95% confidence interval) was 0.827 (0.769–0.870). Among patients with identical diagnoses of neuropathic or non-neuropathic pain, receiver-operating characteristic curve analysis revealed an area under the curve of 0.89. A cut-off point of equal or greater than 4 resulted in a sensitivity of 71% and specificity of 92%.

Conclusion

The Japanese version of the DN4 was found to be a helpful tool for discriminating between neuropathic and non-neuropathic pain.



https://ift.tt/2rlcNkX

Treatment of Tympanic Membrane Retraction Pockets by Excision and Cartilage Tympanoplasty: A Prospective Study

Abstract

To assess the role of cartilage tympanoplasty in management of retraction pockets of the pars flaccida. This was a prospective study at a tertiary care centre. Twenty patients having grade III or grade IV retraction pockets were included in the study. Retraction pockets were treated by excision and cartilage tympanoplasty. Findings noted on follow-up were recorded and analysed. Graft was taken up in 18 (90%) cases with residual perforation in 2 (10%) cases. Recurrence of retraction pockets was observed in 6 (30%) cases. Hearing was improved up to 15 dB in 16 (80%) cases. It is concluded that grade III and IV retraction pockets can be well managed by excision and cartilage tympanoplasty.



https://ift.tt/2jveMyY

Diagnostic Evaluation of Chronic Nasal Obstruction Based on Nasal Endoscopy and CT Scan Paranasal Sinus

Abstract

Evaluation of the accuracy of objective diagnostic modalities for nasal obstruction and their comparison to each other to reach the correct diagnosis with minimum cost and highest accuracy. This study was conducted in the Department of Otorhinolaryngology and Head Neck Surgery, Chirayu Medical College and Hospital, Bhopal from August 2016 to September 2017. A total of 50 patients from age group 1–70 years irrespective of sex with complaints of chronic nasal obstruction, which were unresponsive to routine appropriate medical therapy, were selected for this study. Comparative study among findings of nasal endoscopy and CT scan of the paranasal sinuses done. After clinical examination, patients were subjected to high resolution computed tomography (HRCT) of paranasal sinuses and diagnostic nasal endoscopy (DNE). The diagnostic results of both modalities were compared. The most common symptoms were nasal obstruction and nasal discharge 100%, followed by post nasal drip 62%. The complaints related to eye and ears were less frequent, found in 4% only. CRS (Chronic Rhinosinusitis) was most common pathology of nose for nasal obstruction which is in 72% cases. Sinonasal polyp is present in 20% of cases. Inverted papilloma in 4% cases. Granulomatous disease (Rhinosporidiosis) in 2% cases. Malignancy in 2% cases. In this series of 50 cases, nasal endoscopy revealed various pathological abnormalities mainly in the osteomeatal area. These include mucopurulent discharge in middle meatus seen in 100% of cases (50 patients). This could not be revealed in HRCT. Oedematous and polypoid infundibular mucosa/polyp in nasal cavity in 28% cases (14 patients) where it was not diagnosed in HRCT in three patients. Hence DNE proved superior to HRCT. Other abnormalities detected on nasal endoscopy were septal deviation 80% of cases (40 patients), inferior turbinate hypertrophy 66% of cases (33 patients), middle turbinate hypertrophy/concha bullosa in 48% of cases (24 patients). DNS was diagnosed in 42 patients in HRCT other causes of nasal obstruction such as Agar nasi cell is detected in 16% (8 patients), medialised uncinate process in 16% (8 patients), paradoxical MT in 30% cases were diagnosed more accurately in nasal endoscopy than HRCT. So nasal endoscopy proved better than CT scan. Nasal obstruction is the most common presenting complaint in day to day otolaryngology practice. Nobody would disagree with the role of CT scan and diagnostic nasal endoscopy in diagnosing the nasal and paranasal pathologies. But as a treating physician we are always concerned about early diagnosis and cost effectiveness. At the same time we also have to consider about patient waiting and work load. In this study we attempted to find out whether diagnostic nasal endoscopy can be better then CT scan, so that we can treat our patient appropriately. Though there has been an increased demand for imaging the paranasal sinuses with coronal CT because of functional endoscopic sinus surgery, nasal endoscopy is a better option in diagnosing and assessing the extent of disease and anatomy.



https://ift.tt/2HREGLZ

Treatment of Tympanic Membrane Retraction Pockets by Excision and Cartilage Tympanoplasty: A Prospective Study

Abstract

To assess the role of cartilage tympanoplasty in management of retraction pockets of the pars flaccida. This was a prospective study at a tertiary care centre. Twenty patients having grade III or grade IV retraction pockets were included in the study. Retraction pockets were treated by excision and cartilage tympanoplasty. Findings noted on follow-up were recorded and analysed. Graft was taken up in 18 (90%) cases with residual perforation in 2 (10%) cases. Recurrence of retraction pockets was observed in 6 (30%) cases. Hearing was improved up to 15 dB in 16 (80%) cases. It is concluded that grade III and IV retraction pockets can be well managed by excision and cartilage tympanoplasty.



https://ift.tt/2jveMyY

How Best to Manage Facial Synkinesis?

Abstract

Purpose of Review

Facial synkinesis is a sequela of facial nerve injury that results in involuntary facial movement occurring simultaneously with volitional facial movement. Inability to control facial movement has functional and psychological consequences and can be socially isolating. This review discusses the involved facial nerves and musculature, evaluation of the synkinetic face, and different treatment options.

Recent Findings

We reviewed the literature for advancements and outcomes in assessment, rehabilitation, and non-surgical and surgical treatments for facial synkinesis while highlighting anatomical correlates and movement patterns of commonly affected facial musculature.

Summary

Understanding facial muscular anatomy, including the intended vectors of movement, guides appropriate therapeutic intervention and improves outcomes. Chemodenervation and rehabilitation continue to be the main treatment strategy for facial synkinesis. In select cases, other techniques, such as selective neurolysis, selective myectomy, nerve grafting, or free muscle transfer, are also available.



https://ift.tt/2JX0Glh

Association of reperfusion with brain edema in patients with acute ischemic stroke: A secondary analysis of the MR CLEAN Trial

Kimberly, WT; Dutra, BG; Boers, AMM; Alves, HCBR; Berkhemer, OA; Van Den Berg, L; Sheth, KN; ... Ganpat, RJ; + view all Kimberly, WT; Dutra, BG; Boers, AMM; Alves, HCBR; Berkhemer, OA; Van Den Berg, L; Sheth, KN; Roos, YBWEM; Van Der Lugt, A; Beenen, LFM; Dippel, DWJ; Van Zwam, WH; Van Oostenbrugge, RJ; Lingsma, HF; Marquering, H; Majoie, CBLM; Koudstaal, PJ; Van Den Berg, LA; Nederkoorn, PJ; Beumer, D; Staals, J; Boiten, J; Wermer, MJH; Kappelle, LJ; Van Dijk, EJ; Schonewille, WJ; Hofmeijer, J; Van Oostayen, JA; Vroomen, PC; De Kort, PLM; Keizer, K; De Bruijn, SF; Van Den Berg, JSP; Schreuder, THCML; Aerden, LAM; Flach, HZ; Visser, MC; Den Hertog, HM; Brouwer, PA; Emmer, BJ; Sprengers, MES; Van Den Berg, R; Nijeholt, GJL; Van Walderveen, MAA; Lo, RH; De Vries, J; Vos, JA; Eshghi, O; Tielbeek, AV; Van Dijk, LC; Van Hasselt, BAAM; Heijboer, RJJ; Dallinga, RJ; Bot, JCJ; Gerrits, DG; Fransen, PSS; Marquering, HA; Steyerberg, EW; Yoo, AJ; Jenniskens, SFM; Van Den Berg-Vos, RM; Karas, GB; Brown, MM; Liebig, T; Stijnen, T; Andersson, T; Mattle, H; Wahlgren, N; Van Der Heijden, E; Ghannouti, N; Fleitour, N; Hooijenga, I; Puppels, C; Pellikaan, W; Geerling, A; Lindl-Velema, A; Van Vemde, G; Klinieken, I; De Ridder, A; Greebe, P; De Bont-Stikkelbroeck, J; De Meris, J; Janssen, K; Struijk, W; Licher, S; Boodt, N; Ros, A; Venema, E; Slokkers, I; Ganpat, RJ; - view fewer (2018) Association of reperfusion with brain edema in patients with acute ischemic stroke: A secondary analysis of the MR CLEAN Trial. JAMA Neurology , 75 (4) pp. 453-461. 10.1001/jamaneurol.2017.5162 .

https://ift.tt/2JWCLCb

Feasibility of fluorescence lymph node imaging in colon cancer: FLICC.

Chand, M; Keller, DS; Joshi, HM; Devoto, L; Rodriguez-Justo, M; Cohen, R; (2018) Feasibility of fluorescence lymph node imaging in colon cancer: FLICC. Techniques in Coloproctology 10.1007/s10151-018-1773-6 . (In press).

https://ift.tt/2IdatGr

Angiogenesis and vascular leakage in diabetic retinopathy

Laughlin, William Edward; (2018) Angiogenesis and vascular leakage in diabetic retinopathy. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2JWCLlF

Big data: geodemographics and representation

Lansley, Guy David; (2018) Big data: geodemographics and representation. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2rmqDUh

Less is more: the efficacy of gene therapy to treat Fabry disease

Lambert, JRA; (2018) Less is more: the efficacy of gene therapy to treat Fabry disease. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2JQUACT

Downstream etching of silicon nitride using continuous-wave and pulsed remote plasma sources sustained in Ar/NF3/O-2 mixtures

Huang, S; Volynets, V; Hamilton, JR; Nam, SK; Song, I-C; Lu, S; Tennyson, J; Huang, S; Volynets, V; Hamilton, JR; Nam, SK; Song, I-C; Lu, S; Tennyson, J; Kushner, MJ; - view fewer (2018) Downstream etching of silicon nitride using continuous-wave and pulsed remote plasma sources sustained in Ar/NF3/O-2 mixtures. Journal of Vacuum Science & Technology A , 36 (2) , Article 021305. 10.1116/1.5019673 .

https://ift.tt/2rkkGY2

Empirical Analyses on the Economics of Criminal Justice

Lai, Kit To Keith; (2018) Empirical Analyses on the Economics of Criminal Justice. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2JRWL9g

High-accuracy water potential energy surface for the calculation of infrared spectra

Mizus, II; Kyuberis, AA; Zobov, NF; Makhnev, VY; Polyansky, OL; Tennyson, J; (2018) High-accuracy water potential energy surface for the calculation of infrared spectra. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences , 376 (2115) , Article 20170149. 10.1098/rsta.2017.0149 . Green open access

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Enhancing Registration for Image-Guided Neurosurgery

Kochan, Martin; (2018) Enhancing Registration for Image-Guided Neurosurgery. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Critical evaluation of measured rotational-vibrational transitions of four sulphur isotopologues of (SO2)-O-16

Tobias, R; Furtenbacher, T; Csaszar, AG; Naumenko, OV; Tennyson, J; Flaud, J-M; Kumar, P; Tobias, R; Furtenbacher, T; Csaszar, AG; Naumenko, OV; Tennyson, J; Flaud, J-M; Kumar, P; Poirier, B; - view fewer (2018) Critical evaluation of measured rotational-vibrational transitions of four sulphur isotopologues of (SO2)-O-16. Journal of Quantitative Spectroscopy and Radiative Transfer , 208 pp. 152-163. 10.1016/j.jqsrt.2018.01.006 .

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High Accuracy ab initio Calculations of Rotational-Vibrational Levels of the HCN/HNC System

Makhnev, VY; Kyuberis, AA; Zobov, NF; Lodi, L; Tennyson, J; Polyansky, OL; (2018) High Accuracy ab initio Calculations of Rotational-Vibrational Levels of the HCN/HNC System. Journal of Physical Chemistry A , 122 (5) pp. 1326-1343. 10.1021/acsjpca.7b10483 .

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Functional properties of GAD65 neurons in the lateral hypothalamus

Kosse, CL; (2018) Functional properties of GAD65 neurons in the lateral hypothalamus. Doctoral thesis (Ph.D), UCL (University College London).

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Effects of Fibre Inclusion on Stress Strain Behaviour of a Compacted Over-consolidated Clay From Lambeth Group

Ekinci, A; Ferreira, PMV; (2012) Effects of Fibre Inclusion on Stress Strain Behaviour of a Compacted Over-consolidated Clay From Lambeth Group. In: Indraratna, B and Rujikiatkamjorn, C and Vinod, JS, (eds.) Proceedings of the International Conference on Ground Improvement & Ground Control Transport Infrastructure Development and Natural Hazards Mitigation. Research Publishing Services: Australia.

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Averaged electron collision cross sections for thermal mixtures of beta-alanine conformers in the gas phase

Fujimoto, MM; de Lima, EVR; Tennyson, J; (2017) Averaged electron collision cross sections for thermal mixtures of beta-alanine conformers in the gas phase. Journal of Physics B: Atomic, Molecular and Optical Physics , 50 (19) , Article 195201. 10.1088/1361-6455/aa87bc .

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The Orthodontic-Oral Surgery interface: Part One: A service evaluation and an overview of the diagnosis and management of common anomalies

Sharif, MO; Lyne, A; Parker, K; Chia, M; (2018) The Orthodontic-Oral Surgery interface: Part One: A service evaluation and an overview of the diagnosis and management of common anomalies. British Dental Journal (In press).

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