USB Dermatoscope as an Oculoscopy tool

http://ift.tt/2nCptSP

Demographics and Outcomes of Stage I-II Merkel Cell Carcinoma Treated with Mohs Micrographic Surgery Compared with Wide Local Excision in the National Cancer Data Base

The optimal surgical approach (wide local excision (WLE) vs. Mohs micrographic surgery (MOHS)) for treating Merkel cell carcinoma (MCC) is yet to be determined.

http://ift.tt/2nCprdF

Use of Sterile Urine Cups as Sharps Containers During Mohs Stages

http://ift.tt/2BTfOLL

Using smooth forceps for assisting incision and drainage of an infected epidermoid cyst

http://ift.tt/2BTspP5

Response to comment: Eustachian tube diameter: Is it associated with chronic otitis media development?

We would like to thank the observer for the interest and comments for our research. We also think that Chronic Otitis Media (COM) is a multifactorial disease and there were many factors involved in the pathogenesis. Upper airway infections, recurrent otitis media, dysfunction of the Eustachian Tube (ET) and nasopharynx, ciliary dysfunction, and allergy are among the investigated probable risk factors [1]. Also Chronic Rhinosinusitis (CRS) and Laryngopharyngeal Reflux (LPR) were proven to be involved in the pathogenesis [2,3].

http://ift.tt/2E2xeHX

International survey and consensus (ICON) on ambulatory surgery in rhinology

Publication date: Available online 3 February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): L. de Gabory, L.J. Sowerby, J.M. DelGaudio, A. Al-Hussaini, C. Hopkins, E. Serrano
ObjectivesDay-case surgery is the gold standard to several surgical procedures in Rhinology. However, few data and guidelines have been published except in the Anglo-Saxon countries and France. The aim of this survey was to propose a list of issues arising during day-case surgery in order to analyze the different constraints encountered around the world.Material and methodIt was a prospective multicenter international email survey. The method was based on the formalized expert consensus methodology. A list of 11 issues was based on literature data and was sent by e-mail to 265 key opinion leaders (KOL) who attended the IFOS congress.ResultsThe response rate was 20% from 27 countries without statistical difference between continents concerning the score on each item. The mean age of KOL was 50±10 years. Their mean length of experience was 21±10 years. Issues in relation with technical resources and experience showed that the last time at which ambulatory surgery in the day is possible was 4:00 PM but responses varied depending the availability of technical resources. Bleeding or hematoma occurred most frequently between the third and fourth postoperative day whatever the surgical procedure. A strong agreement and consensus was obtained concerning the nasal packing, septal contention and their schedule of removal which were not a contraindication of day-case. Also 75% of participants were agreeing with a therapeutic education program to improve the performance of postoperative care and decrease readmission rates. A relative agreement without consensus were obtained for the distance between the day-case unit and home, the role of surgery duration and the impact of anticoagulant and/or antiplatelet drugs in overnight admission and readmission rates.ConclusionPractice varies widely owing to local organization constraints and the availability of a dedicated day-case unit seems to be the main limiting factor.



http://ift.tt/2s0L784

International consensus (ICON) on management of otitis media with effusion in children

Publication date: Available online 3 February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): F. Simon, M. Haggard, R.M. Rosenfeld, H. Jia, S. Peer, M.-N. Calmels, V. Couloigner, N. Teissier
Otitis media with effusion (OME) is a common childhood disease defined as the presence of liquid in the middle ear without signs or symptoms of acute ear infection. Children can be impacted mainly with hearing impairment and/or co-occurring recurrent acute otitis media (AOM) thus requiring treatment. Although many meta-analyses and national guidelines have been issued, management remains difficult to standardize, and use of surgical and medical treatments continue to vary. We convened an international consensus conference as part of the 2017 International Federation of Oto-rhino-laryngological Societies Congress, to identify best practices in OME management. Overall, regional differences were minor and consensual management was obtained on several important issues. At initial assessment, although a thorough medical examination is necessary to seek reflux, allergy or nasal obstruction symptoms; an age-appropriate auditory test is the only assessment required in children without abnormal history. Non-surgical treatments poorly address the underlying problem of an age-dependent dysfunctional Eustachian tube; auto-inflation seems to be the only beneficial, low-risk and low-cost non-surgical therapy. There was a clear international recommendation against using steroids, antibiotics, decongestants or antihistamines to treat OME, because of side-effects, cost issues and no convincing evidence of long-term effectiveness. Decisions to insert tympanostomy ventilation tubes should be based on an auditory test but also take into account the child's context and overall hearing difficulties. Tubes significantly improve hearing and reduce the number of recurrent AOM with effusion while in place. Adjuvant adenoidectomy should be considered in children over four years of age, and in those with significant nasal obstruction or infection.



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Erratum to the article “Write your first article, but …” Published in the issue (2017;134(6):371–72), in European Annals of Otorhinolaryngology, Head and Neck diseases. http://ift.tt/2GHZ5yG

Publication date: February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 1





http://ift.tt/2s4QuTI

Hypopharyngeal reconstruction using a circular stapler

Publication date: Available online 2 February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): P. Schultz, A. Dupret-Bories, S. Ciftci, L. Fath
Distal anastomosis by tubed free flap is one of the main technical difficulties encountered during hypopharyngeal reconstruction. Although high flap survival probability can be achieved by experienced surgical teams, two complications are commonly observed at the flap-oesophagus junction: fistula and stenosis. Use of a circular stapler reduced the frequency of these complications by ensuring a perfectly circular and resistant suture line. Salivary stent placement is therefore unnecessary, allowing earlier resumption of feeding. The stapling procedure is simple, but a few technical skills are required, as the stapler is not specifically designed for this purpose. We describe the indications, surgical procedure and global results based on our series. We consider the forearm flap to be the gold standard for this reconstruction, but thicker flaps, such as pectoralis major flap, can also be used, but with poorer results in terms of healing and swallowing performance.



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Editorial Board

Publication date: February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 1





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Contents

Publication date: February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 1





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International consensus (ICON) on basic voice assessment for unilateral vocal fold paralysis

Publication date: Available online 3 February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A. Mattei, G. Desuter, M. Roux, B.-J. Lee, M.-A. Louges, E. Osipenko, B. Sadoughi, B. Schneider-Stickler, A. Fanous, A. Giovanni
There is a growing need for evaluation tools allowing the quantification of the outcome after voice surgeries. Since the end of the 1990s, multiple unfruitful attempts have been made to reach a consensus, including the Dejonckere protocol for the European Laryngological Society in 2001. This suggested to perform objective and quantifiable measures in the following domains: perception, acoustic, aerodynamic, self-evaluation by the patient and videolaryngostroboscopy. But in a PubMed^® search with the keywords "Voice Assessment" and "Voice Outcome" since 2001 retrieving 452 articles, only 33 of them were using methods taking into account the first four dimensions proposed by Dejonckere. To elaborate a new and simpler protocol, we chose to focus on unilateral vocal fold paralyses (UVFP), which represents a homogeneous disease in terms of physiology. This protocol was elaborated on the basis of a review of the literature and of the database and experience of the IFOS panel members. In summary, our group recommends the use and implementation of the ELS "basic protocol" with some minor modifications. Voice audio recordings are an indispensable prerequisite, and may even have medico-legal implications. We recommend the systematic use of the Voice Handicap Index (VHI). Perceptual analysis must be performed by using Hirano's GRB scale and voice breathiness has to be prioritized. Currently, acoustic analysis remains optional given the lack of data to support clinical usefulness. Aerodynamic studies should include at a minimum an evaluation of the Maximum Phonation Time, calculated in seconds following multiple trials in order to obtain a recording representing the patient's best possible glottis closure.



http://ift.tt/2GJnGTS

Thanks to reviewers

Publication date: February 2018
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 1





http://ift.tt/2s2YIvr

A prospective study comparing patients with early and late relapsing pemphigus treated with rituximab

Rituximab (RTX) is an effective therapy for patients with pemphigus. However it does not prevent relapse.

http://ift.tt/2BRLhhC

Efficacy and Safety of Oxymetazoline Cream 1.0% for Treatment of Persistent Facial Erythema Associated With Rosacea: Findings From the 52-Week Open Label REVEAL Trial

Limited treatments are available for persistent erythema of rosacea.

http://ift.tt/2nzoOBH

Prognostic value of sentinel lymph node biopsy according to Breslow thickness for cutaneous melanoma

Sentinel lymph node biopsy (SLNB) is widely performed for melanoma of certain histologic parameters and offers important prognostic and staging information. Breslow thickness (BT) by itself also provides meaningful prognostic information.

http://ift.tt/2BQkxxP

Editorial Board

Publication date: February 2018
Source:Autoimmunity Reviews, Volume 17, Issue 2





http://ift.tt/2s2JjLw

Interaction between microbiome and host genetics in psoriatic arthritis

Publication date: Available online 3 February 2018
Source:Autoimmunity Reviews
Author(s): Maria Sole Chimenti, Carlo Perricone, Lucia Novelli, Francesco Caso, Luisa Costa, Dimitrios Bogdanos, Paola Conigliaro, Paola Triggianese, Cinzia Ciccacci, Paola Borgiani, Roberto Perricone
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, seen in combination with psoriasis. Both genetic and environmental factors are responsible for the development of PsA, however little is known about the different weight of these two distinctive components in the pathogenesis of the disease. Genomic variability in PsA is associated with the disease and/or some peculiar clinical phenotypes. Candidate genes involved are crucial in inflammation, immune system, and epithelial permeability. Moreover, the genesis and regulation of inflammation are influenced by the composition of the human intestinal microbiome that is able to modulate both mucosal and systemic immune system. It is possible that pro-inflammatory responses initiated in gut mucosa could contribute to the induction and progression of autoimmune conditions. Given such premises, the aim of this review is to summarize immune-mediated response and specific bacterial changes in the composition of fecal microbiota in PsA patients and to analyze the relationships between bacterial changes, immune system, and host genetic background.

Graphical abstract

http://ift.tt/2GHM34x

Systematic review of hearing loss after traumatic brain injury without associated temporal bone fracture

While hearing loss following temporal bone fracture is a well-described phenomenon, few data exist on auditory dysfunction in patients with traumatic brain injury (TBI) without temporal bone fracture. Herein, we aim to systematically review hearing loss after TBI without bony fracture and describe its etiologies.

http://ift.tt/2GKbu5n

Psoriasis and cardiovascular disease risk factors. The HUNT Study, Norway

Abstract

Background

Studies have examined the associations between psoriasis and cardiovascular diseases and their risk factors, but the results are conflicting, especially in the general population.

Objectives

To investigate the association of psoriasis, and in particular psoriasis severity, with objectively measured cardiovascular disease risk factors and cardiovascular morbidity in a large population-based cross-sectional study.

Methods

We linked data on 50 245 persons in the HUNT3 Study, Norway with information from the National Prescription Database to obtain information on use of psoriasis medication. A total of 2 894 persons reported to have psoriasis; 2 643 were classified as mild and 251 as moderate/severe psoriasis. We used linear and logistic regression to estimate adjusted associations with 95% confidence intervals (CIs) between psoriasis and cardiovascular disease risk factors and morbidity.

Results

We observed a positive association between psoriasis and objective measures of body mass index (BMI), waist circumference and high-sensitivity C-reactive protein (hsCRP), but no clear association with blood pressure and blood lipids. People with moderate/severe psoriasis had an odds ratio for being overweight of 1.94 (95% CI 1.42, 2.67), whereas the odds ratio for metabolic syndrome was 1.91 (95% CI 1.47, 2.49). Psoriasis was also positively associated with self-reported diabetes, myocardial infarction and angina pectoris.

Conclusions

In this population-based study we found that psoriasis was positively associated with measures of adiposity, as well as with a clustering of cardiovascular disease risk factors. Overall, these associations were strongest for people with moderate/severe psoriasis.

This article is protected by copyright. All rights reserved.

http://ift.tt/2nyGI7A

Hereditary palmoplantar keratodermas. Part II. Syndromic palmoplantar keratodermas. Diagnostic algorithm and principles of therapy

Abstract

Hereditary palmoplantar keratodermas (PPKs) comprise a large and heterogeneous group of disorders characterized by persistent thickening of the epidermis at palmar and plantar surfaces. Clinical and genetic features of isolated and complex PPKs have been reviewed in part I of this 2-part review. Here we focus on clinical and molecular classification of syndromic PPKs which are recognized by additional extracutaneous manifestations, in particular deafness, specific mucosal lesions, cardiomyopathy, inborn errors of metabolism, involvement of internal organs or disorders of sexual development. Other genetic diseases which may show palmoplantar involvement, such as selected subtypes of hereditary epidermolysis bullosa, various hereditary ichthyoses and other keratinization disorders, several ectodermal dysplasias and some multisystem genetic disorders, are also briefly summarized. PPK diagnosis is based on inheritance pattern, age at onset, morphology, distribution and severity of hyperkeratosis, pattern of additional dermatological and systemic manifestations and laboratory findings. Molecular analysis is at present the gold standard to confirm the diagnosis in PPK forms due to mutations in known causative genes. No specific and curative therapy is currently available for PPKs which highly impair patients' quality of life. Topical treatments are symptomatic and offer only temporary relief. Among systemic treatments, retinoids improve disease symptoms in the majority of patients.

This article is protected by copyright. All rights reserved.

http://ift.tt/2nyD0KW

Sensitive skin in france: a study on prevalence, relationship with age and skin type and impact on quality of life

Abstract

Background

Many epidemiological studies have been performed, but a potential increase in the prevalence of sensitive skin as well as its relationship with age and skin type and the impact of sensitive skin on quality of life are still debated.

Objective

To answer these unresolved questions

Methods

An opinion poll was conducted on a representative French 5000-person sample.

Results

Fifty-nine percent of the people declared very sensitive or fairly sensitive skin (together: sensitive skin), and women (66%) declared sensitive skin more frequently than men (51.9%). The results also showed that sensitive skin is more common (more than 60%) in younger people (<35 years old), and there was a decrease in the following age groups. The univariate analysis demonstrated that sensitive skin was more likely to be reported by people with fair skin (OR=1.83) and by people with an atopic predisposition (OR=2.51). The risk of sensitive skin is higher for people with dry skin (OR= 6.18 compared with normal skin), but sensitive skin can occur in other skin types (OR=2.45 for mixed skin and OR=2.16 for greasy skin). Quality of life was clearly altered in patients with sensitive skin, as assessed by SF-12 and DLQI.

Conclusion

This large study demonstrates that sensitive skin can alter quality of life and is more common in young people and in women as well as patients with dry skin or fair skin or an atopic predisposition. It also suggests that there is an increase in the prevalence of sensitive skin.

This article is protected by copyright. All rights reserved.

http://ift.tt/2BSsfro

A Comparative Study of the Efficacy of Fat Plug Myringoplasty and Conventional Myringoplasty in Chronic Suppurative Otitis Media with Small Central Perforation

Abstract

Chronic Otitis Media (COM) is a major cause of acquired hearing impairment especially in developing countries. Persistent perforations occur either due to improper treatment of recurrent otitis media or infected traumatic perforation. Myringoplasty, repair of the Tympanic membrane using autologous temporalis fascia, is the standard procedure for COM. Other graft materials commonly used include tragal perichondrium, tragal cartilage and adipose tissue. This prospective study aims to compare the surgical and audiological outcome of fat plug myringoplasty [FPM] and conventional myringoplasty using temporalis fascia [CM-TF] in COM with small dry central perforation. A total of 60 patients of COM with small dry central perforation, aged 16–60 years, during the study period of October 2013 to August 2015 were divided into two groups of 30 cases each. The first group underwent FPM while the second group underwent CM-TF. The graft uptake and hearing outcome [pre operative and 3 months post operative PTA] were assessed. The surgical outcome of FPM with graft uptake of 86.7% was comparable to CM-TF with a graft uptake of 90%. The mean post operative hearing gain in FPM was 3.43 ± 2.81 dB which correlated well with that of CM-TF with 3.85 ± 3.05 dB. The duration of hospital stay and operative time was significantly lower in FPM group. FPM can be safely performed in cases with dry, small central perforations of the tympanic membrane with outcomes comparable to CM-TF.

http://ift.tt/2EDjYL6

A Comparative Study of the Efficacy of Fat Plug Myringoplasty and Conventional Myringoplasty in Chronic Suppurative Otitis Media with Small Central Perforation

Abstract

Chronic Otitis Media (COM) is a major cause of acquired hearing impairment especially in developing countries. Persistent perforations occur either due to improper treatment of recurrent otitis media or infected traumatic perforation. Myringoplasty, repair of the Tympanic membrane using autologous temporalis fascia, is the standard procedure for COM. Other graft materials commonly used include tragal perichondrium, tragal cartilage and adipose tissue. This prospective study aims to compare the surgical and audiological outcome of fat plug myringoplasty [FPM] and conventional myringoplasty using temporalis fascia [CM-TF] in COM with small dry central perforation. A total of 60 patients of COM with small dry central perforation, aged 16–60 years, during the study period of October 2013 to August 2015 were divided into two groups of 30 cases each. The first group underwent FPM while the second group underwent CM-TF. The graft uptake and hearing outcome [pre operative and 3 months post operative PTA] were assessed. The surgical outcome of FPM with graft uptake of 86.7% was comparable to CM-TF with a graft uptake of 90%. The mean post operative hearing gain in FPM was 3.43 ± 2.81 dB which correlated well with that of CM-TF with 3.85 ± 3.05 dB. The duration of hospital stay and operative time was significantly lower in FPM group. FPM can be safely performed in cases with dry, small central perforations of the tympanic membrane with outcomes comparable to CM-TF.

http://ift.tt/2EDjYL6

Endoscopic Stapes Surgery

The management of stapes fixation using transcanal endoscopic ear surgery is a viable alternative approach. The advantages of transcanal endoscopic ear surgery are improved visualization and illumination of the stapes and oval window regardless of the size and geometry of the external auditory canal. Footplate work and prosthesis placement pose significant but surmountable challenges using transcanal endoscopic ear surgery secondary to the lack of depth perception. Several recent studies demonstrate the efficacy and safety of transcanal endoscopic ear surgery.

http://ift.tt/2DXdxFv

Preoperative laboratory data are associated with complications and surgical site infection in composite head and neck surgical resections

1) Describe normal/abnormal preoperative laboratory testing incidence in head and neck (H&N) composite resections and 2) determine complication, surgical site infection (SSI), and transfusion predictors by laboratory test.

http://ift.tt/2DXXEPc

The treatment of vocal process granuloma

We reviewed with great interest the paper entitled "Comparison of the effects of esomeprazole plus mosapride citrate and botulinum toxin A on vocal process granuloma" by Lei et al. [1]. This is an excellent study. The authors compared the effects on vocal process granulomas (VPGs) of proton pump inhibitors (PPI) together with prokinetic agents and injections of botulinum toxin A. It was concluded that combined PPI and prokinetic drugs played a significant role in VPG treatment after surgery. However, the study design is unusual and the inclusion criteria vague.

http://ift.tt/2nGtRzs

Lifetime Air Pollution Exposure and Asthma in a Pediatric Birth Cohort

Publication date: Available online 2 February 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): M.B. Rice, S.L. Rifas-Shiman, A.A. Litonjua, M.W. Gillman, N. Liebman, I. Kloog, H. Luttmann-Gibson, B.A. Coull, J. Schwartz, P. Koutrakis, E. Oken, M.A. Mittleman, D.R. Gold




http://ift.tt/2GLppZ1

Autophagic dysfunction in Papillon Lefèvre syndrome is restored by recombinant Cathepsin C treatment

Publication date: Available online 2 February 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Pedro Bullón, Beatriz Castejón-Vega, Lourdes Román-Malo, María Paz Jimenez-Guerrero, David Cotán, Tamara Y. Forbes-Hernandez, Alfonso Varela-López, Antonio Pérez-Pulido, Francesca Giampieri, José L. Quiles, Maurizio Battino, José A. Sánchez-Alcázar, Mario D. Cordero
BackgroundCathepsin C (CatC) is a lysosomal enzyme involved in the activation of serine proteases from immune and inflammatory cells. Several mutations with loss of function in the Cathepsin C (CatC) gene have been shown to be the genetic mark of Papillon-Lefèvre syndrome (PLS), a rare autosomal recessive disease characterized by severe early-onset periodontitis, palmoplantar hyperkeratosis and increased susceptibility to infections. Deficiencies or dysfunction in other cathepsin family proteins such as B or D have been associated with autophagic and lysosomal disorders.ObjectivesHere, we characterized the basis for autophagic dysfunction in PLS by analyzing skin fibroblasts derived from patients with several mutations in the CatC gene and reduced enzymatic activity.MethodsSkin fibroblasts were isolated from PLS patients assessed by genetic analysis. Authophagy flux dysfunction was evaluated by examining the accumulation of p62/SQSTM1 and a bafilomycin assay. Ultrastructural analysis further confirmed an abnormal accumulation of autophagic vesicles in mutant cells. A recombinant recombinant CatC (rCatC) protein was produced by a baculovirus system in insect cell cultures.ResultsPLS mutant fibroblasts showed alterations in the oxidative/antioxidative status, reduced oxygen consumption and a marked autophagic dysfunction associated with autophagosome accumulation. These alterations were accompanied by lysosomal permeabilization, CatB release and NLRP3-inflammasome activation. Treatment of mutant fibroblasts with rCatC improved cell growth, autophagic flux and partially restored lysosomal permeabilization.ConclusionsOur data provide a novel molecular mechanism underlying PLS. Impaired autophagy caused by insufficient lysosomal function may represent a new therapeutic target for PLS.



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Comparison of xerostomia incidence after three-dimensional conformal radiation therapy and contralateral superficial lobe parotid-sparing intensity-modulated radiotherapy for oropharyngeal and hypopharyngeal cancer

In the treatment of head–neck cancer, parotid-sparing intensity-modulated radiotherapy (IMRT) could reduce the incidence of xerostomia. When the parotid glands cannot be sufficiently spared because of the widespread tumor, contralateral superficial lobe parotid-sparing (CSLPS)-IMRT could be used to reduce marginal recurrence, however the success of this approach remains to be determined. The primary purpose of this study was to compare the incidence of xerostomia between three-dimensional conformal radiotherapy (3D-CRT) and CSLPS-IMRT for oropharyngeal and hypopharyngeal cancer.

http://ift.tt/2nAzPCA

Endoscopic cartilage versus temporalis fascia grafting for anterior quadrant tympanic perforations — A prospective study in a tertiary care hospital

Management of anterior perforations of tympanic membrane is a surgical challenge. The objective of this study is to analyse and compare the results of composite cartilage perichondrium island (CCPI) graft and temporalis fascia graft by endoscopic technique in anterior quadrant perforations.

http://ift.tt/2BVcpfO

Vespa crabro immunotherapy versus Vespula-venom immunotherapy in Vespa crabro allergy: a comparison study in field re-stings

In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. ...

http://ift.tt/2BV8W0M

Race and ethnicity have significant influence on fractional exhaled nitric oxide

Race and ethnicity have been shown to influence fractional exhaled nitric oxide (FeNO). There is a need to investigate cutoff points for different races and ethnicities to improve clinical application.

http://ift.tt/2GKARnE

Surgical indications or inclusion/exclusion criteria of explorative tympanotomy on sudden sensorineural hearing

We read with great interest the work described in the article entitled, "The role of explorative tympanotomy (EXT) in patients with sudden sensorineural hearing loss with and without perilymphatic fistula," by Prenzler et al. [1]. Sudden sensorineural hearing loss (SSNHL) is a medical emergency frequently seen in patients presenting in the otology clinic. With increasing productivity at work, increased psychological pressure of modern life, and frequent use of headphones, SSNHL has become increasingly common in recent years.

http://ift.tt/2BRiJEV

Rivaroxaban Limits Complement Activation Compared to Warfarin in Antiphospholipid Syndrome Patients with Venous Thromboembolism

Arachchillage, DJ; Mackie, IJ; Efthymiou, M; Chitolie, A; Hunt, BJ; Isenberg, D; Khamashta, M; ... Cohen, H; + view all Arachchillage, DJ; Mackie, IJ; Efthymiou, M; Chitolie, A; Hunt, BJ; Isenberg, D; Khamashta, M; Machin, S; Cohen, H; - view fewer (2015) Rivaroxaban Limits Complement Activation Compared to Warfarin in Antiphospholipid Syndrome Patients with Venous Thromboembolism. Presented at: 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL.

http://ift.tt/2E8cSAn

Quantitative Analysis of Vitreous Inflammation using Optical Coherence Tomography in Patients Receiving Sub-Tenon's Triamcinolone for Uveitic Cystoid Macular Edema

Macdonald, T; Keane, PA; Sreekanth, S; Sim, DA; Murray, PI; Denniston, AK; (2015) Quantitative Analysis of Vitreous Inflammation using Optical Coherence Tomography in Patients Receiving Sub-Tenon's Triamcinolone for Uveitic Cystoid Macular Edema. Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Denver, CO.

http://ift.tt/2FItqfj

Metaphors considered harmful? An exploratory study of the effectiveness of functional metaphors for end-to-end encryption

Demjaha, A; Spring, J; Becker, IF; Parkin, S; Sasse, MA; (2018) Metaphors considered harmful? An exploratory study of the effectiveness of functional metaphors for end-to-end encryption. [Dataset]. UCL Jill Dando Institute of Security and Crime Science: London, UK.

http://ift.tt/2EbkOkc

Can primary care electronic health records facilitate the prediction of early cognitive decline associated with dementia: a systematic literature review

Mackintosh, M; Denaxas, S; Rossor, M; (2017) Can primary care electronic health records facilitate the prediction of early cognitive decline associated with dementia: a systematic literature review. Presented at: Informatics for Health 2017, Manchester, UK. Green open access

http://ift.tt/2FGkUxB

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

Montalban, X; Gold, R; Thompson, AJ; Otero-Romero, S; Amato, MP; Chandraratna, D; Clanet, M; ... Zipp, F; + view all Montalban, X; Gold, R; Thompson, AJ; Otero-Romero, S; Amato, MP; Chandraratna, D; Clanet, M; Comi, G; Derfuss, T; Fazekas, F; Hartung, HP; Havrdova, E; Hemmer, B; Kappos, L; Liblau, R; Lubetzki, C; Marcus, E; Miller, DH; Olsson, T; Pilling, S; Selmaj, K; Siva, A; Sorensen, PS; Sormani, MP; Thalheim, C; Wiendl, H; Zipp, F; - view fewer (2018) ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis. European Journal of Neurology , 25 (2) pp. 215-237. 10.1111/ene.13536 . (In press).

http://ift.tt/2E9kti5

A Qualitative Study of the Influences on Clinical Academic Physicians' Postdoctoral Career Decision-Making

Ranieri, VF; Barratt, H; Rees, G; Fulop, NJ; (2018) A Qualitative Study of the Influences on Clinical Academic Physicians' Postdoctoral Career Decision-Making. Academic Medicine 10.1097/ACM.0000000000002141 . (In press).

http://ift.tt/2FFCp0H

In the fetal thymus, Gli3 in thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh

Solanki, A; Yanez, DC; Ross, S; Lau, C-I; Papaioannou, E; Li, J; Saldaña, JI; Solanki, A; Yanez, DC; Ross, S; Lau, C-I; Papaioannou, E; Li, J; Saldaña, JI; Crompton, T; - view fewer (2018) In the fetal thymus, Gli3 in thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh. Development , 145 (3) , Article dev146910. 10.1242/dev.146910 . Green open access

http://ift.tt/2E9kIK1

Analysis of Oil and Gas Big Data Using Artificial Intelligence

Vahabi, N; (2017) Analysis of Oil and Gas Big Data Using Artificial Intelligence. Presented at: UNSPECIFIED. Green open access

http://ift.tt/2FIqQ9h

Maternal serum concentrations of soluble endoglin and soluble vascular endothelial growth factor receptor 2 may predict the severity of villous hypoplasia in severe early-onset fetal growth restriction

Spencer, R; Sebire, N; Weissbach, T; Krishnan, T; Hutchinson, C; David, A; (2017) Maternal serum concentrations of soluble endoglin and soluble vascular endothelial growth factor receptor 2 may predict the severity of villous hypoplasia in severe early-onset fetal growth restriction. Presented at: Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester, United Kingdom. Green open access

http://ift.tt/2E8cPEH

HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci

Collini, PJ; Bewley, MA; Mohasin, M; Marriott, HM; Miller, RF; Geretti, A-M; Beloukas, A; ... Dockrell, DH; + view all Collini, PJ; Bewley, MA; Mohasin, M; Marriott, HM; Miller, RF; Geretti, A-M; Beloukas, A; Papadimitropoulos, A; Read, RC; Noursadeghi, M; Dockrell, DH; - view fewer (2018) HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201708-1755OC . (In press). Green open access

http://ift.tt/2FGOfrn

A New Method to Calculate Electric Wheelchair Driving Cycles

Barbareschi, G; Holloway, C; (2016) A New Method to Calculate Electric Wheelchair Driving Cycles. Presented at: Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the. IEEE, 2016, Orlando, Florida, USA. Green open access

http://ift.tt/2E9kItv

Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study

Pett, SL; Kunisaki, KM; Wentworth, D; Griffin, TJ; Kalomenidis, I; Nahra, R; Montejano Sanchez, R; ... INSIGHT FLU003 Plus Study Group, .; + view all Pett, SL; Kunisaki, KM; Wentworth, D; Griffin, TJ; Kalomenidis, I; Nahra, R; Montejano Sanchez, R; Hodgson, SW; Ruxrungtham, K; Dwyer, D; Davey, RT; Wendt, CH; INSIGHT FLU003 Plus Study Group, .; - view fewer (2018) Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study. Open Forum Infectious Diseases , 5 (1) , Article ofx228. 10.1093/ofid/ofx228 . Green open access

http://ift.tt/2FIqG1F

CAV3 p.Ala93Thr pathogenic mutation causing hypertrophic cardiomyopathy

Scalco, RS; Savvatis, K; Desikan, M; Parton, M; Turner, C; (2017) CAV3 p.Ala93Thr pathogenic mutation causing hypertrophic cardiomyopathy. Presented at: 22nd International Congress of the WMS, Saint Malo, France.

http://ift.tt/2E9jUEZ

Prenatal famine exposure and mental health in later midlife

van den Broek, T; Fleischmann, M; (2017) Prenatal famine exposure and mental health in later midlife. Aging & Mental Health 10.1080/13607863.2017.1402293 . (In press).

http://ift.tt/2FIqwaz

Misdiagnosis and diagnostic delay in McArdle disease

Scalco, RS; Morrow, J; Booth, S; Chatfield, S; Godfrey, R; Quinlivan, R; (2017) Misdiagnosis and diagnostic delay in McArdle disease. Presented at: 22nd International Congress of the WMS, Saint Malo, France.

http://ift.tt/2EeMZP8

The epidemiology of adolescents living with perinatally-acquired HIV: a cross-region global cohort analysis

The Collaborative Initiative for Paediatric HIV Education and Re, ; Slogrove, AL; Schomaker, M; Davies, M-A; Williams, P; Balkan, S; Ben-Farhat, J; ... Leroy, V; + view all The Collaborative Initiative for Paediatric HIV Education and Re, ; Slogrove, AL; Schomaker, M; Davies, M-A; Williams, P; Balkan, S; Ben-Farhat, J; Calles, N; Chokephaibulkit, K; Duff, C; Eboua, TF; Kekitiinwa, A; Maxwell, N; Pinto, J; Seage III, G; Teasdale, C; Wanless, S; Warszawski, J; Wools-Kaloustian, K; Yotebieng, M; Timmerman, V; Collins, J; Goodall, R; Smith, C; Patel, K; Paul, M; Gibb, DM; Vreeman, R; Abrams, E; Hazra, R; Van Dyke, R; Bekker, L-G; Mofenson, L; Vicari, M; Essajee, S; Penazzato, M; Anabwani, G; Mohapi, EQ; Kazembe, PN; Hlatshwayo, M; Lumumba, M; Goetghebuer, T; Thorne, C; Galli, L; Van Rossum, A; Giaquinto, C; Marczynska, M; Marques, L; Prata, F; Ene, L; Okhonskaia, L; Rojo, P; Fortuny, C; Naver, L; Rudin, C; Le Coeur, S; Volokha, A; Rouzier, V; Succi, R; Sohn, A; Kariminia, A; Edmonds, A; Ayaya, S; Ongwen, P; Jefferys, LF; Phiri, S; Mubiana-Mbewe, M; Sawry, S; Renner, L; Sylla, M; Azbug, MJ; Levin, M; Oleske, J; Chernoff, M; Traite, S; Purswani, M; Chadwick, E; Judd, A; Leroy, V; - view fewer (2018) The epidemiology of adolescents living with perinatally-acquired HIV: a cross-region global cohort analysis. PLoS Medicine (In press). Green open access

http://ift.tt/2FIjin0

Increased non-AIDS mortality among persons with AIDS-defining events after antiretroviral therapy initiation

Pettit, AC; Giganti, MJ; Ingle, SM; May, MT; Shepherd, BE; Gill, MJ; Fätkenheuer, G; ... Antiretroviral Therapy Cohort Collaboration (ART-CC), .; + view all Pettit, AC; Giganti, MJ; Ingle, SM; May, MT; Shepherd, BE; Gill, MJ; Fätkenheuer, G; Abgrall, S; Saag, MS; Del Amo, J; Justice, AC; Miro, JM; Cavasinni, M; Dabis, F; Monforte, AD; Reiss, P; Guest, J; Moore, D; Shepherd, L; Obel, N; Crane, HM; Smith, C; Teira, R; Zangerle, R; Sterne, JA; Sterling, TR; Antiretroviral Therapy Cohort Collaboration (ART-CC), .; - view fewer (2018) Increased non-AIDS mortality among persons with AIDS-defining events after antiretroviral therapy initiation. Journal of the International AIDS Society , 21 (1) , Article e25031. 10.1002/jia2.25031 . Green open access

http://ift.tt/2EcoG4k

Education: Risk Enhancing or Insurance Mechanism?

Delaney, JM; (2017) Education: Risk Enhancing or Insurance Mechanism? Doctoral thesis (Ph.D), UCL (University College London). Green open access

http://ift.tt/2FHyII1

Radiological and clinical outcomes for children with Morquio Syndrome Presenting with Craniocervical Pathology

Eastwood, D; Williams, N; Cleary, M; Thompson, D; (2017) Radiological and clinical outcomes for children with Morquio Syndrome Presenting with Craniocervical Pathology. Presented at: British Orthopaedic Association, Liverpool, UK.

http://ift.tt/2E9RgDx

Complex Partnership for the delivery of Urban Rail Infrastructure Project (URIP): How Culture matters for the treatment of Risk and Uncertainty

Fabianski, Caroline Julie Cecile; (2017) Complex Partnership for the delivery of Urban Rail Infrastructure Project (URIP): How Culture matters for the treatment of Risk and Uncertainty. Doctoral thesis (Ph.D), UCL (University College London).

http://ift.tt/2FDBAp6