Intracranial bleeding (ICB) as a catastrophic complication of Streptococcus gordonii infective endocarditis (IE) in an immunocompetent patient

We present an interesting case of late-onset intracranial bleeding (ICB) as a complication of Streptococcus gordonii causing infective endocarditis. A previously healthy young woman was diagnosed with infective endocarditis. While she was already on treatment for 2 weeks, she had developed seizures with a localising neurological sign. An urgent non-contrasted CT brain showed massive left frontoparietal intraparenchymal bleeding. Although CT angiogram showed no evidence of active bleeding or contrast blush, massive ICB secondary to vascular complication of infective endocarditis was very likely. An urgent decompressive craniectomy with clot evacuation was done immediately to release the mass effect. She completed total 6 weeks of antibiotics and had postoperative uneventful hospital stay despite having a permanent global aphasia as a sequel of the ICB.

https://ift.tt/2wZSL2s

Rare cause of gastric outlet obstruction: xanthogranulomatous cholecystitis

Description 

A 62-year-old Indian female patient presented with right upper quadrant pain and multiple episodes of vomiting for 10 days. She denied history of fever, jaundice, past anorexia/weight loss and previous surgeries. She was dehydrated, tachycardia (120/min) was present, and there was tenderness in the right upper quadrant. Routine investigations revealed presence of anaemia (haemoglobin 9.1 g/dL), raised total leucocyte counts (17 x10^9/L) and hypokalaemia (2.8 mEq/L). All other blood tests (liver function/kidney function/blood sugar and coagulation profile) were normal. Patient was stabilised with intravenous fluids, antibiotics and other supportive management. Imaging with ultrasound (USG) was suboptimal due to the massive intestinal gas and uncooperative nature of the patient. A collapsed gallbladder (GB) and a mass with a smooth curvilinear surface and posterior acoustic shadowing in the distal part of the duodenum were the only distinguishable findings. Due to repeated episodes of vomiting, the patient underwent an upper gastrointestinal endoscopy, which was...

https://ift.tt/2CJ60d5

Tubercular septal abscess in a postoperative patient: a novel entity

Extrapulmonary tuberculosis is a rather uncommon and potentially challenging phenomenon. Such manifestation, particularly in the scenario of a late postoperative period, is extremely rare and requires a high index of suspicion, prompt diagnosis and appropriate treatment.

We present the case scenario of a patient with history of successfully treated pulmonary tuberculosis many years earlier, without any signs of recurrence, who developed primary nasal septal tuberculosis after undergoing septoplasty to correct his septal deviation. His postoperative course remained uneventful for 4 months. He then presented with a spontaneous nasal septal abscess, which proved to be tubercular in nature on investigations. Appropriate diagnosis was established, and the patient was treated successfully with antituberculous therapy.

Recurrent tuberculosis may present a diagnostic challenge for healthcare professionals. Only a high index of suspicion, modern diagnostic tools and institution of appropriate treatment including surgical intervention as required will ensure a promising outcome.

https://ift.tt/2x4Hpdq

Penile cutaneous horn: still an enigma

Description

A 60-year-old man with history of Johanson's staged urethroplasty for pan anterior urethral stricture due to lichen sclerosus et atrophicus 3 months previously presented to us with a cutaneous horn over his glans penis. This horn was previously excised superficially, and now had recurred over the same site in the last 1 month. It was initially small in size and then gradually increased to a size of around 2.5 cm (figure 1). The patient had no documents mentioning the histopathology of previously excised horn. The patient had been circumcised in childhood. He had no history of genital malignancy or other factors that could have been implicated in cutaneous horn formation. He was managed with excision of the horn along with deep biopsy from base of the lesion to rule out any malignant pathology. The excision site healed well, and biopsy revealed benign pathology. At present, patient has...

https://ift.tt/2CPfvr4

Unusual right internal carotid artery supraclinoid segment fenestration associated with multiple aneurysms treated with flow diversion and coiling

Description 

The supraclinoid (carotid-ophthalmic) segment of the internal carotid artery (ICA) under the Bouthillier classification is defined as the segment between the ophthalmic and posterior-communicating arteries.1 We describe an unusual congenital anomaly of the supraclinoid internal carotid artery characterised by a large fenestration of its carotid-ophthalmic segment, associated with multiple aneurysms.

A 60-year-old female patient underwent investigation for persistent headaches and was found to have what appeared to be irregular fusiform dilatation of the intracranial right internal carotid artery on 1.5 T magnetic resonance angiography (MRA) time-of-flight imaging. Cerebral digital subtraction angiography (DSA) performed to further characterise this abnormality demonstrated two discrete aneurysms, one measuring 5 mm and the other 2 mm, arising from the posterior limb of a supraclinoid ICA fenestration (figure 1A).

Figure 1

(A) Three-dimensional reconstruction of a rotational digital subtraction angiogram (DSA) demonstrating the supraclinoid right internal  carotid  artery  (ICA) fenestration....

https://ift.tt/2wZUUvc

Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use

Turmeric dietary supplement sales, which accounted for US$69 million in spending in 2016, have been increasing exponentially in the USA, making this one of the most popular botanical supplements sold in the USA. Herbal supplement use, which is generally regarded as safe by consumers, is not usually reported to healthcare providers. We reported here on a case of autoimmune hepatitis, occurring in a 71-year-old woman taking turmeric dietary supplements for the maintenance of cardiovascular health, which resolved rapidly following discontinuation of the turmeric supplements. Of particular note, turmeric use was not documented in the patient's medical records and the potential causative role of the turmeric supplementation was ultimately identified by the patient rather than the healthcare providers. To our knowledge, this is the first documented report of turmeric supplement-induced autoimmune hepatitis.

https://ift.tt/2CHeHEJ

Current Utilization of Biologicals

FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA

https://ift.tt/2x2F3v0

Copyright

ELSEVIER

https://ift.tt/2Nxl021

Forthcoming Issues

Skin Cancer Surgery

https://ift.tt/2x63uaI

Contributors

J. REGAN THOMAS, MD

https://ift.tt/2NyxXIM

Contents

Gregory S. Keller

https://ift.tt/2x63lnG

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities

Abstract

Oncogenic MYD88 mutations, most notably the Leu 265 Pro (L265P) mutation, were recently identified as potential driver mutations in various B-cell non-Hodgkin Lymphomas (NHLs). The L265P mutation is now thought to be common to virtually all NHLs and occurs in between 4 and 90% of cases, depending on the entity. Since it is tumor-specific, the mutation, and the pathways it regulates, might serve as advantageous therapeutic targets for both conventional chemotherapeutic intervention, as well as immunotherapeutic strategies. Here, we review recent progress on elucidating the molecular and cellular processes affected by the L265P mutation of MYD88, describe a new in vivo model for MyD88 L265P-mediated oncogenesis, and summarize how these findings could be exploited therapeutically by specific targeting of signaling pathways. In addition, we summarize current and explore future possibilities for conceivable immunotherapeutic approaches, such as L265P-derived peptide vaccination, adoptive transfer of L265P-restricted T cells, and use of T-cell receptor-engineered T cells. With clinical trials regarding their efficacy rapidly expanding to NHLs, we also discuss potential combinations of immune checkpoint inhibitors with the described targeted chemotherapies of L265P signaling networks, and/or with the above immunological approaches as potential ways of targeting MYD88-mutated lymphomas in the future.

https://ift.tt/2x2TGhH

Penicillin allergy skin testing is safe in pre-lung transplant patients with low lung volumes

Penicillin allergy is the most frequently reported drug hypersensitivity reaction with a prevalence rate of around 10% in the US 1,2; however, true reactions exist in only around 3% of patients reporting a penicillin allergy 2. Penicillin allergy stigma results in higher health care costs and increased prevalence of multidrug resistant (MDR) organisms. In the pre-lung transplant population there are no data on penicillin skin testing in the setting of severely compromised lung function.

https://ift.tt/2x1ktf2

Comparing Asthma Control Questionnaire (ACQ) and National Asthma Education and Prevention Program (NAEPP) Asthma Control Criteria

Adequate assessment of control is critical to asthma management. The Asthma Control Questionnaire (ACQ) and the National Asthma Education and Prevention Program (NAEPP) criteria are commonly used measures of asthma control.

https://ift.tt/2OdJ8Uc

Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

Cutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediate...

https://ift.tt/2CF9pd6

Anti‐inflammatory and antiradical effects of a 2% diosmin cream in a human skin organ culture as model

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2x1dgvu

Minimally invasive approaches to axillary osmidrosis treatment: A comparison between superficial liposuction with automatic shaver curettage, subcutaneous laser treatment, and microwave‐based therapy with a modified technique

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2O6ds3h

Population Pharmacokinetics of Tafenoquine, a Novel Anti-Malarial [Experimental Therapeutics]

Tafenoquine is a novel 8-aminoquinoline anti-malarial drug recently approved by US Food and Drug Administration (FDA) for the radical cure of acute P. vivax malaria – first new treatment in almost 60 years. Population pharmacokinetic (POP PK) analysis was conducted with tafenoquine exposure data following oral administration from 6 clinical studies in Phase 1 through Phase 3 with a nonlinear mixed effects modelling approach. The impact of patient demographics, baseline characteristics and extrinsic factors such as formulation were evaluated. Model performance was assessed using techniques such as bootstrapping, visual predictive checks and external data validation from a Phase 3 study not used in model fitting and parameter estimation. Based on the analysis, the systemic PK of tafenoquine was adequately described using a two-compartment model. The final POP PK model included body weight (allometric scaling) on apparent oral and intercompartmental clearance (CL/F, Q/F respectively), apparent volume of distribution for central and peripheral compartments (V₂/F, V₃/F respectively), formulation on systemic bioavailability (F1), absorption rate (KA) and health status on apparent volume of distribution. The key tafenoquine population parameters estimates were 2.96 L/hr for CL/F and 915 L for V₂/F in P. vivax malaria infected subjects. Additionally, the analyses demonstrated no clinically relevant difference in relative bioavailability across the capsule and tablet formulations administered in these clinical studies. In conclusion, a POP PK model for tafenoquine was developed. Clinical trial simulations based on this model supported bridging the exposures across two different formulations. This POP PK model can be applied to aid and perform clinical trial simulations in other scenarios and populations such as pediatrics.

https://ift.tt/2x0orEI

Chloroquine analogues as leads against Pneumocystis lung pathogens [Susceptibility]

The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, auto-immune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii, in vitro. Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.

https://ift.tt/2MkiOWM

Isavuconazole for treatment of experimental fungal endophthalmitis caused by Aspergillus fumigatus [Experimental Therapeutics]

Fungal endophthalmitis remains a significant cause of vision impairment and blindness. Moreover, the prognosis is poor, in part, due to delay in diagnosis and limited availability of effective antifungal agents with good ocular penetration. Thus, it is imperative to evaluate the therapeutic efficacy of newer antifungal agents in fungal endophthalmitis. In this study, we assessed the efficacy of isavuconazole in treating Aspergillus fumigatus (AF) endophthalmitis in an exogenous mouse model of the disease. Briefly, endophthalmitis was induced by intravitreal (IVT) injection of AF spores in immunocompetent C57BL/6 (B6) mouse eyes. Mice were randomized into five groups receiving isavuconazole via (1) oral gavage, (2) IVT injections, (3) intravenous, (4) IVT injection followed by oral gavage, and (5) IVT injection followed by intravenous. Our data showed that isavuconazole treatment via all routes reduced fungal burden in AF-infected eyes. This coincided with the preservation of retinal structural integrity (histology analysis) and retinal function (electroretinogram, ERG analysis), resulting in significantly improved disease outcome. Furthermore, isavuconazole treatment reduced the levels of inflammatory cytokines (TNF-α, IL-1β, IL-6) and cellular infiltration in the eyes. Notably, oral administration of isavuconazole was as effective in ameliorating endophthalmitis as intravitreal injection of the drug. Collectively, our study demonstrates that isavuconazole is effective in treating AF endophthalmitis in mice, indicating its potential use in human ocular infections.

https://ift.tt/2x3EQIA

CHARACTERIZATION OF INFLUENZA B VIRUS VARIANTS WITH REDUCED NEURAMINIDASE INHIBITOR SUSCEPTIBILITY [Antiviral Agents]

Treatment options for influenza B virus infections are limited to neuraminidase inhibitors (NAIs) which block the neuraminidase (NA) glycoprotein on the virion surface. The development of NAI resistance would therefore result in a loss of antiviral treatment options for influenza B infections. This study characterized two contemporary influenza B viruses with known resistance-conferring NA amino acid substitutions, D197N and H273Y, detected during routine surveillance. The D197N and H273Y variants were characterized in vitro by assessing NA enzyme activity and affinity, as well as replication in cell culture compared to NAI-sensitive wild-type viruses. In vivo studies were also performed in ferrets to assess the replication and transmissibility of each variant. Mathematical models were used to analyse within-host and between-host fitness of variants relative to wild-type viruses. The data revealed that the H273Y variant had similar NA enzyme function relative to its wild-type but had slightly reduced replication and transmission efficiency in vivo. The D197N variant had impaired NA enzyme function but there was no evidence of reduction in replication or transmission efficiency in ferrets. Our data suggest that the influenza B variant with H273Y NA substitution had a more notable reduction in fitness compared to wild-type viruses than the influenza B variant with the D197N NA substitution. Although a D197N variant is yet to become widespread, it is the most commonly detected NAI-resistant influenza B virus in surveillance studies. Our results highlight the need to carefully monitor circulating viruses for the spread of influenza B viruses with the D197N NA substitution.

https://ift.tt/2MgW6PB

Identification of FDA-approved drugs as antivirulence agents targeting the pqs quorum sensing system of Pseudomonas aeruginosa [Mechanisms of Action]

The long-term use of antibiotics has led to the emergence of multi-drug-resistant bacteria. A promising strategy to combat bacterial infections aims at hampering their adaptability to the host environment without affecting growth. In this context, the intercellular communication system quorum sensing (QS), which controls virulence factor production and biofilm formation in diverse human pathogens, is considered an ideal target.

Here we describe the identification of new inhibitors of the pqs QS system of the human pathogen Pseudomonas aeruginosa, by screening a library of 1,600 FDA-approved drugs. Phenotypic characterization of ad hoc engineered strains and in silico molecular docking demonstrated that the antifungal drugs clotrimazole and miconazole, and an antibacterial compound active against Gram-positive pathogens, clofoctol, inhibit the pqs system, probably by targeting the transcriptional regulator PqsR. The most active inhibitor, clofoctol, specifically inhibited the expression of pqs-controlled virulence traits in P. aeruginosa, such as pyocyanin production, swarming motility, biofilm formation, and expression of genes involved in siderophore production. Moreover, clofoctol protected Galleria mellonella larvae from P. aeruginosa infection and inhibited the pqs QS system in P. aeruginosa isolates from cystic fibrosis patients. Notably, clofoctol is already approved for clinical treatment of pulmonary infections caused by Gram-positive bacterial pathogens, hence this drug has considerable clinical potential as an antivirulence agent for the treatment of P. aeruginosa lung infections.

https://ift.tt/2x1rWeh

Novel self-assembled micelles based on cholesterol-modified antimicrobial peptide (DP7) for safe and effective systemic administration in bacteria-infected animal models [Experimental Therapeutics]

Owing to their broad-spectrum antibacterial properties, multi-target effects and low drug resistance, antimicrobial peptides (AMPs) have played critical roles in the clinical therapy of drug-resistant bacterial infections. However, the potential hazard of haemolysis following systemic administration has greatly limited their application. Here, we developed a novel AMP derivative, DP7-C, by modifying a formerly identified highly active AMP with cholesterol to form an amphiphilic conjugate. The prepared DP7-C easily self-assembled into stable nanomicelles in aqueous solution. Compared to unconjugated counterparts, the DP7-C micelles showed lower haemolytic activity toward human red blood cells and a maximum tolerated dose of 80 mg/kg in mice via intravenous injection, thus demonstrating improved safety. Moreover, by eliciting specific immunomodulatory activities in immune cells, the DP7-C micelles exerted distinct therapeutic effects in zebrafish and mouse infectious models. In conclusion, DP7-C micelles may be an excellent candidate for treatment of bacterial infections in the clinic.

https://ift.tt/2MikL6f

Expression of Pseudomonas aeruginosa antibiotic resistance genes varies greatly during infections in cystic fibrosis patients [Mechanisms of Resistance]

The lungs of individuals with cystic fibrosis (CF) become chronically infected with Pseudomonas aeruginosa that is difficult to eradicate by antibiotic treatment. Two key P. aeruginosa antibiotic resistance mechanisms are the AmpC β-lactamase that degrades β-lactam antibiotics and MexXYOprM, a three-protein efflux pump that expels aminoglycoside antibiotics from the bacterial cells. Levels of antibiotic resistance gene expression are likely to be a key factor in antibiotic resistance but have not been determined during infection. The aims of this research were to investigate expression of the ampC and mexX genes during infection in patients with CF and in bacteria isolated from the same patients. P. aeruginosa isolates from 36 CF patients were grown in laboratory culture and gene expression measured by reverse transcription quantitative PCR (RT-qPCR). Expression of ampC varied over 20,000-fold and that of mexX over 2000-fold between isolates. Expression levels of both genes were on average increased by the presence of sub-inhibitory concentrations of antibiotics. To measure P. aeruginosa gene expression during infection, we carried out RT-qPCR using RNA extracted from fresh sputum samples obtained from 31 patients. Expression of ampC varied over 4000-fold, while mexX expression varied over 100-fold, between patients. Despite these wide variations, median levels of expression of ampC in sputum were similar to those in laboratory-grown bacteria. Expression of mexX was higher in sputum than in laboratory-grown bacteria. Overall, our data demonstrate that genes that contribute to antibiotic resistance can be highly expressed in patients but there is extensive isolate-to-isolate and patient-to-patient variation.

https://ift.tt/2x8cFZl

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond

Abstract

With immunotherapy enjoying a rapid resurgence based on the achievement of durable remissions in some patients with agents that derepress immune function, commonly referred to as "checkpoint inhibitors," enormous attention developed around the IDO1 enzyme as a metabolic mediator of immune escape in cancer. In particular, outcomes of multiple phase 1/2 trials encouraged the idea that small molecule inhibitors of IDO1 may improve patient responses to anti-PD1 immune checkpoint therapy. However, recent results from ECHO-301, the first large phase 3 trial to evaluate an IDO1-selective enzyme inhibitor (epacadostat) in combination with an anti-PD1 antibody (pembrolizumab) in advanced melanoma, showed no indication that epacadostat provided an increased benefit. Here we discuss several caveats associated with this failed trial. First is the uncertainty as to whether the target was adequately inhibited. In particular, there remains a lack of direct evidence regarding the degree of IDO1 inhibition within the tumor, and previous trial data suggest that sufficient drug exposure may not have been achieved at the dose tested in ECHO-301. Second, while there is a mechanistic rationale for the combination tested, the preclinical data were not particularly compelling. More efficacious combinations have been demonstrated with DNA damaging modalities which may therefore be a more attractive alternative. Third, as a highly selective IDO1 inhibitor, epacadostat was advanced aggressively despite preclinical genetic evidence of tumors bypassing IDO1 blockade. Indeed, a well-grounded literature starting in 2011 points to targeting strategies that account for both IDO and tryptophan 2,3-dioxygenase as more appealing directions to pursue, including dual inhibitors and inhibitors of nodal downstream effector pathways such as aryl hydrocarbon receptor blockade. Overall, the clinical readout from a single trial with significant limitations is by no means a definitive test for the field. While biomarker information yet to be gleaned from ECHO-301 may yet reveal useful information regarding IDO1 pathway drugs, better rationalized compounds and better rationalized trial designs will be important in the future to accurately gauge medical impact.

https://ift.tt/2CE0f0d

Perspectives on interferon-alpha in the treatment of Polycythemia vera and related Myeloproliferative neoplasms: minimal residual disease and cure?

Abstract

The first clinical trials of the safety and efficacy of interferon-alpha2 (IFN-alpha2) were performed about 30 years ago. Since then, several single-arm studies have convincingly demonstrated that IFN-alpha2 is a highly potent anti-cancer agent in several cancer types but unfortunately not being explored sufficiently due to a high toxicity profile when using non-pegylated IFN-alpha2 or high dosages or due to competitive drugs, that for clinicians at first glance might look more attractive. Within the hematological malignancies, IFN-alpha2 has only recently been revived in patients with the Philadelphia-negative myeloproliferative neoplasms—essential thrombocytosis, polycythemia vera, and myelofibrosis (MPNs)—and in patients with chronic myelogenous leukemia (CML) in combination with tyrosine kinase inhibitors. In this review, we tell the IFN story in MPNs from the very beginning in the 1980s up to 2018 and describe the perspectives for IFN-alpha2 treatment of MPNs in the future. The mechanisms of actions are discussed and the impact of chronic inflammation as the driving force for clonal expansion and disease progression in MPNs is discussed in the context of combination therapies with potent anti-inflammatory agents, such as the JAK1–2 inhibitors (licensed only ruxolitinib) and statins as well. Interferon-alpha2 being the cornerstone treatment in MPNs and having the potential of inducing minimal residual disease (MRD) with normalization of the bone marrow and low-JAK2V617F allele burden, we believe that combination therapy with ruxolitinib may be even more efficacious and hopefully revert disease progression in many more patients to enter the path towards MRD. In patients with advanced and transforming disease towards leukemic transformation or having transformed to acute myeloid leukemia, "triple therapy" is proposed as a novel treatment modality to be tested in clinical trials combining IFN-alpha2, DNA-hypomethylator, and ruxolitinib. The rationale for this "triple therapy" is given, including the fact that even in AML, IFN-alpha2 as monotherapy may revert disease progression. We envisage a new and bright future with many more patients with MPNs obtaining MRD on the above therapies. From this stage—and even before—vaccination strategies may open a new horizon with cure being the goal for some patients.

https://ift.tt/2x1uc53

Usage of the HINTS exam and neuroimaging in the assessment of peripheral vertigo in the emergency department

Abstract

Background

Dizziness is a common presenting symptom in the emergency department (ED). The HINTS exam, a battery of bedside clinical tests, has been shown to have greater sensitivity than neuroimaging in ruling out stroke in patients presenting with acute vertigo. The present study sought to assess practice patterns in the assessment of patients in the ED with peripherally-originating vertigo with respect to utilization of HINTS and neuroimaging.

Methods

A retrospective cohort study was performed using data pertaining to 500 randomly selected ED visits at a tertiary care centre with a final diagnostic code related to peripherally-originating vertigo between January 1, 2010 - December 31, 2014.

Results

A total of 380 patients met inclusion criteria. Of patients presenting to the ED with dizziness and vertigo and a final diagnosis of non-central vertigo, 139 (36.6%) received neuroimaging in the form of CT, CT angiography, or MRI. Of patients who did not undergo neuroimaging, 17 (7.1%) had a bedside HINTS exam performed. Almost half (44%) of documented HINTS interpretations consisted of the ambiguous usage of "HINTS negative" as opposed to the terminology suggested in the literature ("HINTS central" or "HINTS peripheral").

Conclusions

In this single-centre retrospective review, we have demonstrated that the HINTS exam is under-utilized in the ED as compared to neuroimaging in the assessment of patients with peripheral vertigo. This finding suggests that there is room for improvement in ED physicians' application and interpretation of the HINTS exam.

https://ift.tt/2NCwIIQ

Spontaneous reduction of acute cecal herniation through the foramen of Winslow

Abstract

This is the case of a 70-year-old woman who presented to the emergency department complaining of 2 hours of acute-onset epigastric pain. She had experienced this pain once before which had spontaneously resolved. Axial imaging demonstrated the cecum in an abnormal position within the lesser sac, as well as compression of the inferior vena cava and portal vein. She was taken emergently to the operating room for laparotomy, where a free-floating cecum and ascending colon was identified without ischemia, and a right hemicolectomy was performed. Foramen of Winslow hernias are rare internal hernias with a high rate of strangulation and bowel ischemia, requiring urgent surgical intervention. Operative treatment depends on the type of herniated viscera. Spontaneous reduction is not well documented.

https://ift.tt/2Qhy0qZ

Topical Selenium Sulfide for the Treatment of Hyperkeratosis

Abstract

Hyperkeratosis presents as thickened skin. It can be congenital or acquired. Typically, it affects the palms and soles; the distribution of epidermal involvement is either diffuse, focal, or punctate. Microscopically, the pathologic signature of hyperkeratosis is marked orthokeratosis of the stratum corneum. Topical treatments provide the mainstay of therapy for hyperkeratosis. These include keratolytics (such as urea, salicylic acid, and lactic acid) and retinoids; physical debridement, topical corticosteroids, and phototherapy (using topical psoralen and ultraviolet A phototherapy) are other local therapeutic modalities. Selenium is a non-metallic essential element; its water-insoluble salt, selenium sulfide, is an active ingredient that is used (in either a foam, lotion, or shampoo) to treat not only seborrheic dermatitis but also tinea versicolor. Three individuals with hyperkeratosis involving their palms and/or soles are described; the hyperkeratosis was successful treated with topical selenium sulfide in either a 2.5% lotion/shampoo or a 2.75% foam. The response to topical selenium sulfide was not only rapid but also complete and sustained; none of the patients experienced any adverse events secondary to the therapy. In conclusion, we recommend that topical selenium sulfide be added to the therapeutic armamentarium for congenital or acquired hyperkeratosis—particularly for those patients with involvement of their palms and soles.

https://ift.tt/2x28eOK

Mentalization-based approaches to working with families

Asen, E; Midgley, N; (2019) Mentalization-based approaches to working with families. In: Bateman, A and Fonagy, P, (eds.) Handbook of mentalizing in mental health practice. American Psychiatric Publishing: Washington DC, USA. (In press).

https://ift.tt/2CGjpCV

2016–17 Central Italy Earthquake Sequence: Seismic Retrofit Policy and Effectiveness

Mazzoni, S; Castori, G; Galasso, C; Calvi, P; Dreyer, R; Fischer, E; Fulco, A; ... Magenes, G; + view all Mazzoni, S; Castori, G; Galasso, C; Calvi, P; Dreyer, R; Fischer, E; Fulco, A; Sorrentino, L; Wilson, J; Penna, A; Magenes, G; - view fewer (2018) 2016–17 Central Italy Earthquake Sequence: Seismic Retrofit Policy and Effectiveness. Earthquake Spectra 10.1193/100717EQS197M . (In press). Green open access

https://ift.tt/2NyoalY

Associations of stunting at 2 years with body composition and blood pressure at 8 years of age: longitudinal cohort analysis from lowland Nepal

Wells, JCK; Devakumar, D; Manandhar, DS; Saville, N; Chaube, SS; Costello, A; Osrin, D; (2018) Associations of stunting at 2 years with body composition and blood pressure at 8 years of age: longitudinal cohort analysis from lowland Nepal. European Journal of Clinical Nutrition 10.1038/s41430-018-0291-y . (In press). Green open access

https://ift.tt/2CGiXod

Methods of space maintenance for premature loss of a primary molar: a review

Ahmad, AJ; Parekh, S; Ashley, PF; (2018) Methods of space maintenance for premature loss of a primary molar: a review. European Archives of Paediatric Dentistry 10.1007/s40368-018-0357-5 . (In press). Green open access

https://ift.tt/2NugilA

Black, Red, and Yellow: Cross-Racial Coalitions and Conflicts in the Early African American Scientific Imagination

Yao, C; (2018) Black, Red, and Yellow: Cross-Racial Coalitions and Conflicts in the Early African American Scientific Imagination. Occasion: Interdisciplinary Humanities Journal , 12 pp. 1-11. Green open access

https://ift.tt/2CEIpdB

Settlement location models, archaeological survey data and social change in Bronze Age Crete

Spencer, C; Bevan, A; (2018) Settlement location models, archaeological survey data and social change in Bronze Age Crete. Journal of Anthropological Archaeology 10.1016/j.jaa.2018.09.001 . (In press).

https://ift.tt/2NufZHs

Unanimous rules in the laboratory

Bouton, L; Llorente-Saguer, A; Malherbe, F; (2017) Unanimous rules in the laboratory. Games and Economic Behavior , 102 (C) pp. 179-198. 10.1016/j.geb.2016.12.001 . Green open access

https://ift.tt/2CFz9G6

Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

D'Esposito, A; Sweeney, P; Ali, M; Saleh, M; Ramasawmy, R; Roberts, T; Agliardi, G; ... Walker-Samuel, S; + view all D'Esposito, A; Sweeney, P; Ali, M; Saleh, M; Ramasawmy, R; Roberts, T; Agliardi, G; Desjardins, A; Lythgoe, M; Pedley, R; Shipley, R; Walker-Samuel, S; - view fewer (2018) Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours. Nature Biomedical Engineering (In press).

https://ift.tt/2NB84YK

Mitigation of hysteresis due to a pseudo-photochromic effect in thermochromic smart window coatings

Sol, CWO; Schläfer, J; Parkin, I; Papakonstantinou, I; (2018) Mitigation of hysteresis due to a pseudo-photochromic effect in thermochromic smart window coatings. Scientific Reports , 8 , Article 13249. 10.1038/s41598-018-31519-x . Green open access

https://ift.tt/2CGhPAZ

Characterisation of Bardet Biedl Syndrome by post-mortem microfocus computed tomography (micro-CT)

Shelmerdine, SC; Singh, M; Simcock, I; Calder, AD; Ashworth, M; Beleza, A; Sebire, NJ; Shelmerdine, SC; Singh, M; Simcock, I; Calder, AD; Ashworth, M; Beleza, A; Sebire, NJ; Arthurs, OJ; - view fewer (2018) Characterisation of Bardet Biedl Syndrome by post-mortem microfocus computed tomography (micro-CT). Ultrasound in Obstetrics & Gynecology 10.1002/uog.19190 . (In press).

https://ift.tt/2NB7Ssu

Sources and pattern of protein intake and risk of overweight or obesity in young UK twins

Pimpin, L; Jebb, SA; Johnson, L; Llewellyn, C; Ambrosini, GL; (2018) Sources and pattern of protein intake and risk of overweight or obesity in young UK twins. British Journal of Nutrition pp. 1-10. 10.1017/S0007114518002052 . (In press).

https://ift.tt/2CGhuOJ

Cross-sectional study of a UK cohort of neonatal vein of Galen malformation

Lecce, F; Robertson, F; Rennie, A; Heuchan, A-M; Lister, P; Bhate, S; Bhattacharya, J; ... Ganesan, V; + view all Lecce, F; Robertson, F; Rennie, A; Heuchan, A-M; Lister, P; Bhate, S; Bhattacharya, J; Brew, S; Kanagarajah, L; Kucznynski, A; Peters, MJ; Ridout, D; Schmitt, A; Toolis, C; Vargha-Khadem, F; Ganesan, V; - view fewer (2018) Cross-sectional study of a UK cohort of neonatal vein of Galen malformation. Annals of Neurology 10.1002/ana.25316 . (In press).

https://ift.tt/2NxoMsb

Homotypic and heterotypic psychopathological continuity: a child cohort study

Shevlin, M; McElroy, E; Murphy, J; (2017) Homotypic and heterotypic psychopathological continuity: a child cohort study. Social Psychiatry and Psychiatric Epidemiology , 52 (9) pp. 1135-1145. 10.1007/s00127-017-1396-7 . Green open access

https://ift.tt/2CGh8rn

Impact of CMV PCR Blips in Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation

Lodding, IP; Mocroft, A; da Cunha Bang, C; Gustafsson, F; Iversen, M; Kirkby, N; Perch, M; ... Lundgren, JD; + view all Lodding, IP; Mocroft, A; da Cunha Bang, C; Gustafsson, F; Iversen, M; Kirkby, N; Perch, M; Rasmussen, A; Sengeløv, H; Sørensen, SS; Lundgren, JD; - view fewer (2018) Impact of CMV PCR Blips in Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation. Transplantation Direct , 4 (6) , Article e355. 10.1097/TXD.0000000000000787 . Green open access

https://ift.tt/2NynX2a

Small satellites with MEMS x-ray telescopes for x-ray astronomy and solar system exploration

Ezoe, Y; Miyoshi, Y; Kasahara, S; Kimura, T; Ishikawa, K; Fujimoto, M; Mitsuda, K; ... Branduardi-Raymont, G; + view all Ezoe, Y; Miyoshi, Y; Kasahara, S; Kimura, T; Ishikawa, K; Fujimoto, M; Mitsuda, K; Sahara, H; Isobe, N; Nakajima, H; Ohashi, T; Nagata, H; Funase, R; Ueno, M; Branduardi-Raymont, G; - view fewer (2018) Small satellites with MEMS x-ray telescopes for x-ray astronomy and solar system exploration. In: Proceedings of SPIE Astronomical Telescopes + Instrumentation 2018. (pp. 106990V-1). SPIE: Austin, TX, USA. Green open access

https://ift.tt/2CGgUAx

Interrupted versus uninterrupted NOAC peri-implantation of cardiac device: A single-centre randomised prospective pilot trial

Ricciardi, D; Creta, A; Colaiori, I; Scordino, D; Ragni, L; Picarelli, F; Calabrese, V; ... Di Sciascio, G; + view all Ricciardi, D; Creta, A; Colaiori, I; Scordino, D; Ragni, L; Picarelli, F; Calabrese, V; Providência, R; Ioannou, A; Di Sciascio, G; - view fewer (2018) Interrupted versus uninterrupted NOAC peri-implantation of cardiac device: A single-centre randomised prospective pilot trial. Pacing and Clinical Electrophysiology 10.1111/pace.13482 . (In press).

https://ift.tt/2Nuxnf5

INTERVAL (investigation of NICE technologies for enabling risk-variable-adjusted-length) dental recalls trial: a multicentre randomised controlled trial investigating the best dental recall interval for optimum, cost-effective maintenance of oral health in dentate adults attending dental primary care

Clarkson, JE; Pitts, NB; Bonetti, D; Boyers, D; Braid, H; Elford, R; Fee, PA; ... INTERVAL Trial Collaboration, .; + view all Clarkson, JE; Pitts, NB; Bonetti, D; Boyers, D; Braid, H; Elford, R; Fee, PA; Floate, R; Goulao, B; Humphris, G; Needleman, I; Norrie, JDT; Ord, F; van der Pol, M; Ramsay, CR; Ricketts, DNJ; Worthington, HV; Young, L; INTERVAL Trial Collaboration, .; - view fewer (2018) INTERVAL (investigation of NICE technologies for enabling risk-variable-adjusted-length) dental recalls trial: a multicentre randomised controlled trial investigating the best dental recall interval for optimum, cost-effective maintenance of oral health in dentate adults attending dental primary care. BMC Oral Health , 18 , Article 135. 10.1186/s12903-018-0587-2 . Green open access

https://ift.tt/2CQDLcL

Ethnic Cleansing and Its Alternatives in Wartime: A Comparison of the Austro-Hungarian, Ottoman, and Russian Empires

Bulutgil, HZ; (2017) Ethnic Cleansing and Its Alternatives in Wartime: A Comparison of the Austro-Hungarian, Ottoman, and Russian Empires. International Security , 41 (4) pp. 169-201. 10.1162/ISEC_a_00277 . Green open access

https://ift.tt/2NuepW0

Takayasu's aorto-arteritis: Not your regular lesion for angioplasty

Navdeep Singh, Vivek Athwani, Vikas Bansal, Shaveta Kundra

Annals of Pediatric Cardiology 2018 11(3):312-314

We report a case of a 6-year-old female child with Takayasu's aorto-arteritis (TA) with severe coarctation of the aorta which resulted in an aortic dissection post-ballooning. This happened despite ensuring that markers for disease activity were negative, with appropriate corticosteroid therapy started before the procedure, and using a low-profile, low-pressure, and slightly undersized balloon for dilating the stenotic segment. It required immediate endovascular stenting to tide over the crisis. Following the procedure, she became normotensive with well-palpable lower limb pulses.

https://ift.tt/2MiQWSU

Repaired congenital heart disease and our social milieu

Krishna S Iyer

Annals of Pediatric Cardiology 2018 11(3):233-234



https://ift.tt/2NtPRwu

Is transposition a defect of laterality?

Robert H Anderson, John Stickley

Annals of Pediatric Cardiology 2018 11(3):235-236



https://ift.tt/2MiQHY0

Anomalous origin of the right coronary artery from the pulmonary artery associated with an aortopulmonary window

Padebettu Subramanya Seetharama Bhat, Chandana Nirmala Chandrashekar, Divya Mallikarjun, SL Girish Gowda

Annals of Pediatric Cardiology 2018 11(3):325-327

Anomalous origin of the right coronary artery (RCA) from the pulmonary artery is a rare entity that causes chronic left-to-right shunting of blood from the RCA, through the coronary collaterals into the pulmonary artery. This results in persistent myocardial ischemia and ventricular dysfunction. Association of this anomaly with an aortopulmonary window worsens the condition further due to an additional shunt. We encountered a combination of these two anomalies along with an ostium secundum atrial septal defect in a 10-month-old baby who presented with excessive crying and failure to thrive. Evaluation by transthoracic echocardiography and cardiac computed tomography scan confirmed the diagnosis. Intrapulmonary baffle was done using a pericardial patch to connect the RCA origin to ascending aorta through the aortopulmonary window, similar to Takeuchi procedure. Concomitantly, ostium secundum atrial septal defect was also closed.

https://ift.tt/2NtVjPO

Transposition of the great arteries: A laterality defect in the group of heterotaxy syndromes or an outflow tract malformation?

Rana S Al-Zahrani, Samaher H Alharbi, Rawan M A Tuwaijri, Bayan T Alzomaili, Alaa Althubaiti, Talat Mesud Yelbuz

Annals of Pediatric Cardiology 2018 11(3):237-249

Background/Aim: Transposition of the great arteries (TGA) is traditionally classified as a "conotruncal heart defect", implying that TGA evolves from abnormal development of the outflow tract (OFT) of the embryonic heart. However, recently published genetic data suggest that TGA may be linked to laterality gene defects rather than OFT gene defects. The aim of our study was to clarify whether there is any statistically significant link between TGA and clinically diagnosed laterality defects (heterotaxy). Methods: Retrospective cross-sectional analysis of 533 patients diagnosed with TGA at our cardiac center over a period of 13 years (2002-2015). Hospital informatics and digital data recording systems were used for collecting patients' data and all patients were reviewed to check the echocardiograms for verification of the diagnosis, type (TGA, congenitally corrected TGA (ccTGA), and levo-position of the great arteries (LGA)), complexity of TGA, and all other variables (e.g., abdominal organ arrangement, cardiac position, presence or absence of other cardiac defects). Results: Of 533 TGA patients, 495 (92.9%) had the usual arrangement of the internal organs, 21 (3.9%) had mirror-imagery, 7 (1.3%) had left and 10 (1.8%) had right isomerism. 444 (83.3%) patients had TGA. The number of patients who had usual visceral arrangement in each TGA type was: 418 (94.1%) in TGA, 49 (92.4%) in ccTGA, and 28 (77.7%) in LGA. 6 (1.4%) TGA patients, 4 (11.1%) patients with LGA were found to have right isomerism, while no ccTGA patient presented with this asymmetry. 4 (0.9%) TGA patients, 1 (1.9%) ccTGA patient and 2 (5.6%) patients with LGA had left isomerism. Heterotaxy (mirror-imagery, left and right isomerism) was more associated with LGA than TGA or ccTGA with a statistically significant difference (P value of 0.001). Conclusion: In contrast to recently published genetic data, our morphological data do not disclose a significant link between TGA and heterotaxy.

https://ift.tt/2O4faSP

Endovascular management of vein of Galen aneurysmal malformation in a neonate

Siddharthan Deepti, Rajnish Juneja, Leve Joseph Devarajan Sebastian

Annals of Pediatric Cardiology 2018 11(3):304-307

A term baby presented on the 7th day of life in cardiogenic shock due to vein of Galen aneurysmal malformation. A successful embolization of the malformation was performed through transarterial route on day 12 of life after a period of initial stabilization.

https://ift.tt/2NtPHFo

Validation of the accuracy of handheld echocardiography for diagnosis of congenital heart disease

Sulafa Ali, Tajudeen Bushari

Annals of Pediatric Cardiology 2018 11(3):250-254

Background: Handheld echocardiography (HHE) has been increasingly used for rheumatic heart disease screening and in adult emergency room settings. Aims: This study aimed to validate the accuracy of HHE in the diagnosis of congenital heart disease (CHD). Settings and Design Methodology: This is a prospective study carried out at three pediatric cardiology outpatient clinics in Khartoum, Sudan. All patients with suspected CHD were evaluated by clinical examination followed by HHE, performed using a modified segmental approach. Then, a complete study was performed using a standard echocardiography machine. The results were then compared using appropriate statistical tools. Results: A total of eighty cases were included with the following diagnoses either in isolation or combination: ventricular septal defect (n = 23), atrial septal defect (n = 10), pulmonary stenosis (n = 7), tetralogy of Fallot (n = 7), patent ductus arteriosus (n = 6), atrioventricular septal defect (n = 6), transposition of the great arteries (n = 6), and other diagnoses (n = 15). Agreement between HHE and SE was excellent both for visualizing heart segments (κ =77%–100% with a mean of 92.9%) and for diagnosis of CHD (κ =66%–100% with a mean of 91.7%). The sensitivity of HHE was 69.2%–100% (mean = 90.2%) and specificity was 98.5%–100% (mean = 99.3%). Conclusion: This study supports extending the utility of HHE in children for screening of CHD in addition to its current role in rheumatic heart disease screening.

https://ift.tt/2O4eZa7

Neonatal supraventricular extrasystole as early clinical debut of cardiac rhabdomyoma

Roger Esmel-Vilomara, Amparo Castellote, Luz Santana, Dimpna Calila Albert

Annals of Pediatric Cardiology 2018 11(3):318-321

We are reporting the case of a newborn with a diagnosis of frequent supraventricular extrasystoles, up to 25% of beats at Holter monitoring, and partial response to beta-blockers. Initial echocardiographic studies were normal until the identification of a right atrial mass at 4 months of life. Given the progressive growth of the mass and the suspicion of myxoma or thrombus in the magnetic resonance study, surgical resection of the tumor was performed. The surgical specimen was histologically diagnostic of rhabdomyoma. Currently, the patient remains asymptomatic after a 6-year follow-up period. A single rhabdomyoma is described, located in an atypical situation, near the crista terminalis, and diagnosed from frequent extrasystoles which appeared before the echocardiographic resolution was able to identify it. Magnetic resonance showed nondiagnostic tissue enhancement characteristics.

https://ift.tt/2NtV33i

Predictors of abnormal electrocardiograms in the pediatric emergency department

Shiv Gandhi, Miranda Lin, Sharon R Smith, Jesse J Sturm

Annals of Pediatric Cardiology 2018 11(3):255-260

Background: Electrocardiograms (ECGs) are ordered in the pediatric emergency room for a wide variety of chief complaints. Objectives: Criteria are lacking as to when physicians should obtain ECGs. This study uses a large retrospective cohort of 880 pediatric emergency department (ED) patients to highlight objective criteria including significant medical history and specific vital sign abnormalities to guide clinicians as to which patients might have an abnormal ECG. Methods: Retrospective review of Pediatric ED charts in all patients aged < 18 years who had ECG performed during ED stay. Pediatric ED physician interpretation of the ECG, clinical data on vital signs and past medical history was collected from the medical record for analysis. Results: Of 880 ECGs performed in the ED, 17.4% were abnormal. When controlled for medical history and demographic differences, abnormal ECGs were associated with age-adjusted abnormal ED vital signs including increased heart rate (odds ratio [OR] 1.85, 95% confidence interval [CI] 1.1–3.09) and increased respiratory rate (OR 1.74, CI 1.42–2.62). In a logistic regression analysis, certain chief complaints and history components were less likely to have abnormal ECGs including complaints of chest pain (OR 0.38, CI 0.18–0.80) and known history of gastrointestinal or respiratory condition (i.e., asthma) (OR 0.48, CI 0.29–0.79). Conclusions: In this cohort of patients, those with a chief complaint of chest pain or known respiratory conditions and normal age-adjusted vital signs in the ED have low likelihood of an abnormal ECG.

https://ift.tt/2ObgpiQ

Professor Ivatury Mritunjay Rao

Krishna Subramony Iyer

Annals of Pediatric Cardiology 2018 11(3):330-331



https://ift.tt/2NtUXZu

Native aortic coarctation in neonates and infants: Immediate and midterm outcomes with balloon angioplasty and surgery

Supratim Sen, Sandeep Garg, Suresh G Rao, Snehal Kulkarni

Annals of Pediatric Cardiology 2018 11(3):261-266

Background: Native aortic coarctation in young infants can be treated surgically or with balloon angioplasty, although the latter approach remains controversial. We sought to compare midterm outcomes of balloon and surgical coarctoplasty at our center and to review the current practices in literature. Methods: The study design was a retrospective record review. Patients with coarctation aged <1 year who underwent balloon or surgical coarctoplasty at our center (January 2010–January 2016) with >6-month post-procedure follow-up were studied. Patients with significant arch hypoplasia or interruption, long-segment coarctation, and associated intracardiac lesions were excluded from the study. Clinical, echocardiographic, and procedural details were recorded at initial presentation and follow-up. Need for reintervention was noted. Results: Out of a total of 75 patients, 28 underwent balloon (Group A) and 47 underwent surgical coarctoplasty (Group B). There were two deaths in Group B (mortality 4.2%) and none in Group A. In neonates, 63.6% of Group A and 17.4% of Group B patients required reintervention (P = 0.007). Beyond the neonatal age, 29.4% of Group A and 41.6% of Group B patients required reintervention (not statistically significant). On univariate analysis, residual coarctation on predischarge echocardiogram was the only significant predictor of reintervention (P = 0.04). On Kaplan–Meier analysis, with neonatal presentation, freedom from reintervention in Group B was significantly higher than Group A (P = 0.028). Conclusion: In neonates with native aortic coarctation, surgery unequivocally yields better immediate and midterm results and is the preferred treatment modality. In older infants, balloon coarctoplasty has good early and midterm outcomes with acceptable reintervention rates and should be considered a viable alternative to surgery, especially in critical patients with high surgical risk.

https://ift.tt/2MjZlFI

Successful Angiojet® aortic thrombectomy of extracorporeal membrane oxygenation-related thrombus in a newborn

Maria Elena Gutierrez, Jeffrey A Alten, Mark A Law

Annals of Pediatric Cardiology 2018 11(3):300-303

Thrombosis and systemic embolization are important complications of extracorporeal membrane oxygenation (ECMO). We present a 2.5 kg neonate born at 37.4 weeks with hypoplastic left heart supported on ECMO that developed an acute, occlusive distal aortic thrombus that was emergently managed by transcatheter Angiojet® (Boston Scientific, Boston, MA) thrombectomy. The procedure successfully restored perfusion to the lower extremities with sustained result upon 1-week follow-up. This case highlights the Angiojet® thrombectomy as a treatment option for limb- or organ-threatening acute thrombus in even the most complex ECMO patients.

https://ift.tt/2NtUSoE

Early outcomes of modification of end to side repair of coarctation of aorta with arch hypoplasia in neonates and infants

Anil Kumar Dharmapuram, Nagarajan Ramadoss, Sudeep Verma, Goutami Vejendla, Rao Mrutyunjaya Ivatury

Annals of Pediatric Cardiology 2018 11(3):267-274

Background: In coarctation of aorta associated with proximal arch hypoplasia, extended end-to-end anastomosis through a thoracotomy would result in a residual gradient between the origins of the innominate and the left common carotid arteries. To eliminate this, we modified the surgical technique. Patients and Methods: Between March 2012 and May 2017, 50 patients (14 neonates) underwent repair of coarctation of aorta through a thoracotomy. The age ranged from 6 days to 2 years (median 2 months) and the weight from 1.8 to 8.0 kg (median 4.3 kg). A total of 15 patients (Group A) underwent repair by the extended end-to-end anastomosis. Among them, two patients developed early restenosis at the proximal arch requiring surgical reintervention. Hence, in the second half of the study, 35 patients (Group B) who were identified to have significant hypoplasia of the proximal arch underwent a modified end-to-side anastomosis of the descending aorta to the proximal arch incorporating the distal ascending aorta in the anastomosis and leaving the left subclavian artery end of the isthmus as an end-on vessel. Results: One neonate in Group B died due to a cause not related to the repair. All the other patients in Group B are doing well without a residual gradient during a median follow-up of 23 months. There were no airway issues related to extensive mobilization of the aorta. Conclusion: End-to-side anastomosis of the descending aorta to the proximal arch and side of the ascending aorta is possible through a thoracotomy and can be achieved with good outcome in neonates and infants.

https://ift.tt/2O7q3Dv

Morphology of intramural ventricular septal defects: Clinical imaging and autopsy correlation

Neil D Patel, Richard W Kim, Suwanna Pornrattanarungsi, Pierre C Wong

Annals of Pediatric Cardiology 2018 11(3):308-311

An intramural ventricular septal defect (IVSD) is a type of interventricular communication that can occur following biventricular repair of a conotruncal malformation. There have been no previous reports depicting the actual pathologic anatomy of this defect. We describe two cases of IVSDs with their clinical imaging and postmortem pathology.

https://ift.tt/2Nu4EHo

Modified technique for uncommon coarctation of the aorta with arch hypoplasia

Brijesh Parayaru Kottayil, Praveen R Bayya, Luis Baquero, Amitabh C Sen, Raman K Kumar

Annals of Pediatric Cardiology 2018 11(3):275-277

A true presubclavian coarctation of the aorta with arch hypoplasia without major intracardiac anomaly can result in a surgical dilemma. Theoretically, one can avoid repair through median sternotomy using selective cerebral perfusion and its sequelae since no major intracardiac repair is needed. Repair through thoracotomy is technically challenging if arch reconstruction is required and precise surgical planning is required to avoid spinal hypoperfusion and to maintain cerebral perfusion. Moreover, inadequate repair often has resulted in hypoplastic aortic arch or residual coarctation on follow-up requiring future intervention. We have employed a modified surgical repair through thoracotomy avoiding cardiopulmonary bypass to address presubclavian coarctation of the aorta with diffuse arch hypoplasia with theoretically less chance for future stenosis.

https://ift.tt/2Mhu85X

Balloon angioplasty for supravalvular aortic stenosis as an early complication following arterial switch operation

Kaitlin Carr, Osamah Aldoss, Bijoy Thattaliyath, Manish Bansal

Annals of Pediatric Cardiology 2018 11(3):315-317

Supravalvular aortic stenosis as an early complication of transposition of the great artery repair is rare with few cases reported. Furthermore, transcatheter intervention is uncommon as surgical re-intervention has been traditionally done. We describe two cases of supravalvular aortic stenosis at the anastomotic site as an early complication of the arterial switch operation. Both patients underwent balloon angioplasty of the supravalvular aorta with improvement in postangioplasty gradients and angiographic appearance. Both patients at short-term follow-up had persistent improved gradient without need for further intervention.

https://ift.tt/2NtUzdu

Descending aortic translocation procedure for relief of bronchial compression in left aortic arch and right descending aorta

Roy Varghese, Ronak Sheth, Sivakumar Kothandam

Annals of Pediatric Cardiology 2018 11(3):278-281

Compression of the left bronchus by a right-sided descending aorta arising from a left aortic arch constitutes an exceedingly rare form of vascular ring. This manuscript describes the surgical technique that involves translocation of the descending aorta directly to the proximal ascending aorta, thereby relieving the bronchial compression.

https://ift.tt/2MdpI08

Total anomalous pulmonary venous connection masking an aortopulmonary window: A rare combination of defects

Shyamajit Samaddar, Dheeraj Bhatt, Munish Guleria, Dinesh Kumar Yadav, Anubhav Gupta

Annals of Pediatric Cardiology 2018 11(3):322-324

The association of aortopulmonary (AP) window with total anomalous pulmonary venous connection (TAPVC) has so far not been reported. We report a unique case of an 8-month-old child who presented with congestive cardiac failure and severe pulmonary arterial hypertension. Initial echocardiography revealed supracardiac TAPVC. Cardiac computed tomography showed the presence of Type I AP window along with the TAPVC. In the presence of severe pulmonary hypertension and dilated right ventricle, AP window may easily be missed if not actively looked for.

https://ift.tt/2NtUjLy

Rationale and design of long-term outcomes and vascular evaluation after successful coarctation of the aorta treatment study

Jose D Martins, Justin Zachariah, Elif Seda Selamet Tierney, Uyen Truong, Shaine A Morris, Shelby Kutty, Sarah D de Ferranti, Jonathan Rhodes, Marta Antonio, Maria Guarino, Boban Thomas, Diana Oliveira, Kimberlee Gauvreau, Nuno Jalles, Tal Geva, Miguel Carmo, Ashwin Prakash

Annals of Pediatric Cardiology 2018 11(3):282-296

Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty, or stent implantation. Although short-term results are excellent with all three treatment modalities, long-term cardiovascular (CV) morbidity and mortality remain high, likely due to persistently abnormal vascular function. The effects of treatment modality on long-term vascular function remain uncharacterized. The goal of this study is to assess vascular function in this patient population for comparison among the treatment modalities. Methods: We will prospectively assess vascular Afunction in large and small arteries fusing multiple noninvasive modalities and compare the results among the three groups of CoA patients previously treated using surgery, balloon angioplasty, or stent implantation after frequency matching for confounding variables. A comprehensive vascular function assessment protocol has been created to be used in 7 centers. Our primary outcome is arterial stiffness measured by arterial tonometry. Inclusion and exclusion criteria have been carefully established after consideration of several potential confounders. Sample size has been calculated for the primary outcome variable. Conclusion: Treatment modalities for CoA may have distinct impact on large and small arterial vascular function. The results of this study will help identify the treatment modality that is associated with the most optimal level of vascular function, which, in the long term, may reduce CV risk.

https://ift.tt/2Mgkfpe

Coronary-to-pulmonary artery collaterals in pulmonary atresia

Deepa Sasikumar, Bijulal Sasidharan, Anoop Ayyappan, Arun Gopalakrishnan, Kavasseri M Krishnamoorthy

Annals of Pediatric Cardiology 2018 11(3):328-329

A 2-month-old baby with ventricular septal defect and pulmonary atresia was found to have coronary-to-pulmonary artery collaterals. Cardiac computed tomography confirmed the coronary collaterals and showed the absence of other systemic to pulmonary artery collaterals. Although these collaterals do not cause coronary ischemia, it is important to delineate them by accurate imaging to plan the appropriate surgical strategy.

https://ift.tt/2NtU96U

Die intraorale Sprachaufnahme – die Perspektive einer neuen Smartphone-basierten Methode zur stimmlichen Rehabilitation

Zusammenfassung

Die stimmliche Rehabilitation nach einer Laryngektomie ist obligat. Das Ziel des Projekts bestand darin, eine Smartphone-basierte Methode zu entwickeln, bei der ein Mikrofon in der Mundhöhle zur Aufnahme der Pseudoflüsterstimme platziert und diese durch eine Spracherkennungssoftware analysiert wird – mit nachfolgender Sprachsynthese. Eine Mikrofonkapsel wurde an 10 extra- und intraoralen Positionen platziert (2-mal vor dem Mund (2 cm und 20 cm Abstand), 5‑mal am harten Gaumen und 3‑mal mandibulär). An diesen Stellen erfolgte bei 8 gesunden Männern die Stimmaufnahme und anschließende Analyse sowie Textausgabe durch eine Spracherkennungssoftware. Dieser Text wurde mit dem Prüfungstext verglichen. Der Mittelwert der intraoralen Erkennungsrate aller Positionen betrug 19,3 % im Vergleich zur extraoralen Rate von 75,2 % (p = 0,01). Intraoral wiesen die Messungen an der Maxilla (22,8 %) im Vergleich zur mandibulären Platzierung (13,5 %) einen Vorteil auf (p = 0,01). Die beste Erkennung war am höchsten Punkt des harten Gaumens mit 31,9 % (p = 0,028) gegeben. Weitere Versuche müssen in Abhängigkeit von der technischen Weiterentwicklung der Smartphones in Bezug auf Verarbeitungsgeschwindigkeit und Spracherkennungsapplikationen durchgeführt werden.

https://ift.tt/2oU7WWz

Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors

Haploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable. Historically, the decision of considering haploidentical transplant has remained elusive; however, with the recent advances, the consideration of haploidentical grafts as a treatment option has become more apparent for both allografting for diseases and engraftment failure. We are reporting here an anecdotal case of a successful haploidentical engraftment in a patient with the prior graft failure of an HLA-matched related donor. Since the patient was severely alloimmunized, desensitization protocol was utilized before the haploidentical transplant, and the patient after 8 months of her second allogeneic transplantation is doing great with successful engraftment, no relapse, and no graft-versus-host disease (GVHD). Numerous reports pertinent to haploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in the morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more feasible and has meaningful implications in the situations where matched donors are infrequent.

https://ift.tt/2x2s8K8

A new model framework for circumgalactic Ly α radiative transfer constrained by galaxy-Ly α forest clustering

Kakiichi, K; Dijkstra, M; (2018) A new model framework for circumgalactic Ly α radiative transfer constrained by galaxy-Ly α forest clustering. Monthly Notices of the Royal Astronomical Society , 480 (4) pp. 5140-5159. 10.1093/mnras/sty2214 . Green open access

https://ift.tt/2CFI6iA

All-optical dual photoacoustic and optical coherence tomography intravascular probe

Mathews, SJ; Little, C; Loder, CD; Rakhit, RD; Xia, W; Zhang, EZ; Beard, PC; ... Desjardins, AE; + view all Mathews, SJ; Little, C; Loder, CD; Rakhit, RD; Xia, W; Zhang, EZ; Beard, PC; Finlay, MC; Desjardins, AE; - view fewer (2018) All-optical dual photoacoustic and optical coherence tomography intravascular probe. Photoacoustics , 11 pp. 65-70. 10.1016/j.pacs.2018.07.002 . Green open access

https://ift.tt/2wZQzrD

Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate

Hecht, M; Veigure, R; Couchman, L; Barker, SCI; Standing, JF; Takkis, K; Evard, H; ... Kipper, K; + view all Hecht, M; Veigure, R; Couchman, L; Barker, SCI; Standing, JF; Takkis, K; Evard, H; Johnston, A; Herodes, K; Leito, I; Kipper, K; - view fewer (2018) Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate. Bioanalysis , 10 (15) pp. 1229-1248. 10.4155/bio-2018-0078 .

https://ift.tt/2CFIhKM

The ATHENA X-ray Integral Field Unit (X-IFU)

Barret, D; Lam Trong, T; Den Herder, JW; Piro, L; Cappi, M; Houvelin, J; Kelley, R; ... Cobo, B; + view all Barret, D; Lam Trong, T; Den Herder, JW; Piro, L; Cappi, M; Houvelin, J; Kelley, R; Mas-Hesse, JM; Mitsuda, K; Paltani, S; Rauw, G; Rozanska, A; Wilms, J; Bandler, S; Barbera, M; Barcons, X; Bozzo, E; Ceballos, MT; Charles, I; Costantini, E; Decourchelle, A; Den Hartog, R; Duband, L; Duval, JM; Fiore, F; Gatti, F; Goldwurm, A; Jackson, B; Jonker, P; Kilbourne, C; MacCuli, C; Mendez, M; Molendi, S; Orleanski, P; Pajot, F; Pointecouteau, E; Porter, F; Pratt, GW; Prêle, D; Ravera, L; Sato, K; Schaye, J; Shinozaki, K; Thibert, T; Valenziano, L; Valette, V; Vink, J; Webb, N; Wise, M; Yamasaki, N; Douchin, F; Mesnager, JM; Pontet, B; Pradines, A; Branduardi-Raymont, G; Bulbul, E; Dadina, M; Ettori, S; Finoguenov, A; Fukazawa, Y; Janiuk, A; Kaastra, J; Mazzotta, P; Miller, J; Miniutti, G; Naze, Y; Nicastro, F; Scioritino, S; Simonescu, A; Torrejon, JM; Frezouls, B; Geoffray, H; Peille, P; Aicardi, C; André, J; Daniel, C; Clénet, A; Etcheverry, C; Gloaguen, E; Hervet, G; Jolly, A; Ledot, A; Maussang, I; Paillet, A; Schmisser, R; Travert, JM; Vella, B; Damery, JC; Boyce, K; DIpirro, M; Lotti, S; Schwander, D; Smith, S; Van Leeuwen, BJ; Van Weers, H; Clerc, N; Cobo, B; - view fewer (2018) The ATHENA X-ray Integral Field Unit (X-IFU). In: Proceedings of SPIE Astronomical Telescopes + Instrumentation 2018. (pp. 106991G). SPIE: Austin, Texas, United States. Green open access

https://ift.tt/2x01xO2

A Multiple Single Case Design Study of Dialectical Behaviour Therapy Skills Groups for Bulimia Nervosa: Are they associated with an increase in Mindfulness and Acceptance?

Akinyemi, SS; (2016) A Multiple Single Case Design Study of Dialectical Behaviour Therapy Skills Groups for Bulimia Nervosa: Are they associated with an increase in Mindfulness and Acceptance? Doctoral thesis (D.Clin.Psy), UCL (University College London). Green open access

https://ift.tt/2CFHuJO

MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration

Finger, RP; Schmitz-Valckenberg, S; Schmid, M; Rubin, GS; Dunbar, H; Tufail, A; Crabb, DP; ... MACUSTAR Consortium, .; + view all Finger, RP; Schmitz-Valckenberg, S; Schmid, M; Rubin, GS; Dunbar, H; Tufail, A; Crabb, DP; Binns, A; Sánchez, CI; Margaron, P; Normand, G; Durbin, MK; Luhmann, UFO; Zamiri, P; Cunha-Vaz, J; Asmus, F; Holz, FG; MACUSTAR Consortium, .; - view fewer (2018) MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration. Ophthalmologica 10.1159/000491402 . (In press). Green open access

https://ift.tt/2x2BhT3

Towards A Framework for Holistic Contextual Design for Low-Resource Settings

Aranda-Jan, CB; Jagtap, S; Moultrie, J; (2016) Towards A Framework for Holistic Contextual Design for Low-Resource Settings. International Journal of Design , 10 (3) pp. 43-63. Green open access

https://ift.tt/2CCqrZ1

The diversity challenge in models of occupants' presence in buildings

Mahdavi, A; Tahmasebi, F; O'Brien, W; Gunay, HB; (2017) The diversity challenge in models of occupants' presence in buildings. In: Building Simulation Applications BSA 2017. (pp. pp. 339-344). bu,press: Bozen-Bolzano, Italy. Green open access

https://ift.tt/2wYP5he

Sentinels at the wall: epithelial‐derived cytokines serve as triggers of upper airway type 2 inflammation

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2oWyLJK

Total intravenous anesthesia vs inhaled anesthetic for intraoperative visualization during endoscopic sinus surgery: a double blind randomized controlled trial

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2CDUPT4

Day light photodynamic therapy with BF‐200 ALA: A case series

Dermatologic Therapy, EarlyView.


https://ift.tt/2x1cf62

Facial nevus depigmentosus getting remarkable repigmentation by treatment with a 308‐nm excimer laser: A case report

Dermatologic Therapy, EarlyView.


https://ift.tt/2Nu3iwb

Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes

This work was designed to investigate the antibacterial activities of methanol extracts from thirteen Cameroonian edible plants and their antibiotic-potentiating effects against Gram-negative multidrug-resistant (MDR) phenotypes. The broth microdilution method was used to evaluate the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts, as well as their antibiotic-potentiating activities. The phytochemical screening of the extracts was carried out according to the standard methods. The results of phytochemical tests revealed the presence of sterols, polyphenols, and tannins in most of the tested extracts, with the other classes of secondary metabolites being selectively distributed. Tested extracts showed variable antibacterial activities with MIC values ranging from 64 to 1024 μg/mL. However, some extracts were significantly active against certain bacterial strains: seeds extract of Theobroma cacao (64 μg/mL) against Escherichia coli AG100Atet and Klebsiella pneumoniae K24, and the bark extract of Uapaca guineensis against E. coli ATCC 8739. The leaves extract of T. cacao displayed the best MBC values (256 μg/mL) against E. aerogenes EA27. Some tested extracts included extracts from the leaves of T. cacao and P. vulgaris, and the seeds of D. edulis and barks A. indica has selectively improved (2- to 64-fold) the antibacterial activities of some of the tested antibiotics, chloramphenicol (CHL), tetracycline (TET), kanamycin (KAN), streptomycin (STR), and erythromycin (ERY), against more than 70% of tested MDR bacteria. The findings of this work showed that tested plant extracts and particularly those from T. cacao and Phaseolus vulgaris can be used alone or in combination with conventional antibiotics in the treatment of infections involving multiresistant bacteria.

https://ift.tt/2O5HDHI

Stereotaktische Strahlentherapie im Stadium I des nichtkleinzelligen Lungenkarzinoms

Zusammenfassung

Die stereotaktische Strahlentherapie des nichtkleinzelligen Lungenkarzinoms im Stadium I (SBRT) hat sich als Standardbehandlung für funktionell inoperable Patienten durchgesetzt. Mit hohen lokalen Kontrollraten von regelmäßig annähernd 90 % und einem hohen krankheitsspezifischen (aktuarischen) Überleben nach 5 Jahren von etwa 75 % wurde mit der SBRT als nichtinvasiver Behandlung ein erheblicher Fortschritt erzielt. Ihre Anwendung ist mittlerweile flächendeckend etabliert, stellt jedoch hohe Ansprüche an die technisch-apparative Ausstattung und Qualitätssicherung in den einzelnen Zentren. Die Wahl entsprechender Fraktionierungsschemata hängt dabei insbesondere von der Unterscheidung zwischen zentraler und peripherer Tumorlokalisation ab. Mit entsprechend angepassten Dosisregimen ist die Behandlungsverträglichkeit insgesamt sehr gut. Bezüglich der postinterventionellen Morbidität und Mortalität ist die SBRT sublobären Resektionen bei Patienten mit fortgeschrittener COPD (Chronic Occlusive Pulmonary Disease, GOLD III oder IV) überlegen. Für das operable Stadium I zeigte sich in kleineren Kollektiven (insbesondere auch in der Auswertung von zwei abgebrochenen prospektiv-randomisierten Studien), dass die Behandlungsergebnisse der SBRT bei entsprechend limitierter klinischer Evidenz an jene von leitliniengerecht (lobär) resezierten Patienten heranreichen. Aussichtsreiche laufende klinische Studien prüfen u. a. die SBRT als Boost nach Radiochemotherapie im Stadium III sowie die Kombination von SBRT und immuntherapeutischen Ansätzen im Stadium I.

https://ift.tt/2x2X5wW

Factors Associated with Sport-Related Post-concussion Headache and Opportunities for Treatment

Abstract

Purpose of Review

The purpose of this review is to (1) describe factors both pre- and post-injury that are associated with post-concussion headache, (2) describe the influence of post-concussion headache on recovery following concussion, and (3) provide potential post-concussion treatment options that may reduce the burden of headache, as well as other symptoms to facilitate recovery.

Recent Findings

Various factors may be associated with post-concussion headache presentation. These may include pre-injury or historical factors such as sex, family and self-history of headache and migraine, concussion history, and mood disorders. In addition, post-injury presentation factors for consideration may include injury mechanism, symptom clusters, cervicogenic dysfunction, and post-concussion physiologic dysfunction. Despite this complex interplay of factors, many treatment options may improve headache symptoms and recovery post-concussion including rehabilitation programs focusing on deficits such as visual-vestibular dysfunction, sub-symptom threshold exercise, and potential pharmacological interventions.

Summary

Concussion is a complex injury that results in a variety of sequelae with headache being one of the most common. Understanding factors related to post-concussion headache presentation and the available options for treatment may improve patient care and outcomes post-concussion.

https://ift.tt/2MiTSz4

Nasal challenges in allergen immunotherapy trials

Purpose of review The nasal allergen challenge (NAC) model can be a valuable diagnostic tool for allergic rhinitis. Alongside its clinical use, NACs can be used as primary and secondary endpoints in studies evaluating allergen immunotherapy (AIT) products for allergic rhinitis treatment. This review will discuss the technical aspects of the NAC model and provide a summary of recent studies using NACs to assess existing and new AIT treatments. Recent findings Over the last 2 years, both titrated and single-dose nasal challenge protocols have been used to evaluate immunotherapies targeting grass, birch, house dust mite, and cat allergens. Early efficacy and dose-finding trials showed improvements in allergic symptoms and nasal tolerance to allergens after AIT treatment with standardized extracts or modified forms of whole allergen. NACs were also used in two proof-of-concept studies to illustrate the efficacy of intralymphatic immunotherapy with two concomitant allergens and subcutaneous immunotherapy with Fel d 1-specific IgG-blocking antibodies. Summary Along with existing therapies, nasal challenges are useful in evaluating AIT treatments in the very early stages of clinical development. However, because of the variety in challenge techniques and symptom assessments available, special attention must be placed in the protocol design in order to compare the study results with existing NAC publications. Correspondence to Anne K. Ellis, MD, MSc, FRCPC, Professor and Chair, Division of Allergy and Immunology, Allergy Research Unit, Kingston General Health Research Institute, Watkins 1D, 76 Stuart Street, Kingston, ON K7L 2V7, Canada. Tel: +1 613 548 2336; fax: +1 613 546 3079; e-mail: ellisa@queensu.ca Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2MfWopS

Asymptomatic hyperkeratotic linear plugs on the right hand of a young woman

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2oVUEbO

Neutrophilic fixed drug eruption: a mimic of neutrophilic dermatoses

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2wXZFoc

Nephrogenic systemic fibrosis: in a child with primary hyperoxaluria

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2N0HPvu

Facial monomorphic papules

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2x1lrXZ

Serum elafin as a potential inflammatory marker in psoriasis

International Journal of Dermatology, EarlyView.


https://ift.tt/2wY2BB3

Levels of miR‐31 and its target genes in dermal mesenchymal cells of patients with psoriasis

International Journal of Dermatology, EarlyView.


https://ift.tt/2wY5P8B

Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta‐analysis

British Journal of Dermatology, EarlyView.


https://ift.tt/2Mf5S4G

Alopecia areata: a review of disease pathogenesis

British Journal of Dermatology, EarlyView.


https://ift.tt/2MYaKjQ

Long-Term Safety and Efficacy of Minimally Invasive Lumbar Decompression Procedure for the Treatment of Lumbar Spinal Stenosis With Neurogenic Claudication: 2-Year Results of MiDAS ENCORE

Background and Objectives This study evaluated the long-term durability of the minimally invasive lumbar decompression (MILD) procedure in terms of functional improvement and pain reduction for patients with lumbar spinal stenosis and neurogenic claudication due to hypertrophic ligamentum flavum. This is a report of 2-year follow-up for MILD study patients. Methods This prospective, multicenter, randomized controlled clinical study compared outcomes for 143 patients treated with MILD versus 131 treated with epidural steroid injections. Follow-up occurred at 6 months and at 1 year for the randomized phase and at 2 years for MILD subjects only. Oswestry Disability Index, Numeric Pain Rating Scale, and Zurich Claudication Questionnaire were used to evaluate function and pain. Safety was evaluated by assessing incidence of device-/procedure-related adverse events. Results All outcome measures demonstrated clinically meaningful and statistically significant improvement from baseline through 6-month, 1-year, and 2-year follow-ups. At 2 years, Oswestry Disability Index improved by 22.7 points, Numeric Pain Rating Scale improved by 3.6 points, and Zurich Claudication Questionnaire symptom severity and physical function domains improved by 1.0 and 0.8 points, respectively. There were no serious device-/procedure-related adverse events, and 1.3% experienced a device-/procedure-related adverse event. Conclusions MILD showed excellent long-term durability, and there was no evidence of spinal instability through 2-year follow-up. Reoperation and spinal fracture rates are lower, and safety is higher for MILD versus other lumbar spine interventions, including interspinous spacers, surgical decompression, and spinal fusion. Given the minimally invasive nature of this procedure, its robust success rate, and durability of outcomes, MILD is an excellent choice for first-line therapy for select patients with central spinal stenosis suffering from neurogenic claudication symptoms with hypertrophic ligamentum flavum. Clinical Trial Registration This study was registered at ClinicalTrials.gov, identifier NCT02093520. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Accepted for publication June 8, 2018. Address correspondence to: Peter S. Staats, MD, MBA, National Spine and Pain Centers, 170 Avenue at the Common, Ste 6, Shrewsbury, NJ 07702 (e-mail: peterstaats@hotmail.com). P.S.S. and R.M.B. are study principal investigators for MiDAS ENCORE. In this role, they have been responsible for study oversight. Responsibilities include protocol review, assistance with site selection, site investigator support, oversight of patient enrollment and protocol compliance, and adjudication of adverse events. This trial was sponsored by Vertos Medical. The sponsorship includes study-related supplies and expenses, as well as funding for statistical analysis services by an independent provider. The authors declare no conflict of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.rapm.org). Copyright © 2018 by American Society of Regional Anesthesia and Pain Medicine.

https://ift.tt/2wUHWxC

Best perioperative practice in management of ambulatory patients with obstructive sleep apnea

Purpose of review The perioperative outcome in obstructive sleep apnea (OSA) patients undergoing ambulatory surgery can be potentially impacted by the type of anesthetic technique, fluid management and choice of anesthetic agents. This review highlights the best perioperative practices in the management of OSA patients undergoing ambulatory surgical procedures. Recent findings A recent meta-analysis found that STOP-Bang might be used as a perioperative risk stratification tool. Patients with high-risk OSA (STOP-Bang ≥3) were found to be associated with an increased risk of postoperative complications and prolonged length of hospital stay compared with low-risk OSA (STOP-Bang 0-2) patients undergoing noncardiac surgical procedures. A bidirectional relationship exists between OSA and difficult airway. Both suspected or diagnosed OSA may be associated with either difficult intubation or difficult mask ventilation or both. A recent meta-analysis identified OSA as an important risk factor for opioid-induced respiratory depression. A dose–response relationship was shown between the morphine equivalent daily dose and death or near-death events in OSA patients undergoing surgery. Postoperative continuous monitoring is recommended for high-risk OSA patients receiving opioids. Minimising the dose of muscle relaxant, neuromuscular monitoring and ensuring complete reversal of neuromuscular blockade before extubation is essential in OSA patients to avoid postoperative complications. Whenever feasible, regional anesthesia with multimodal analgesia may be considered as a better alternative to general anesthesia in OSA patients. Summary Patients with OSA and associated comorbidities present a challenge to anesthesiologists as they are at a high risk of perioperative complications. It is important to identify patients with OSA, with the goal to raise awareness among providers, mitigate risk and improve outcomes. Correspondence to Frances Chung, Professor, Department of Anesthesia, Toronto Western Hospital, University Health Network, 399 Bathurst Street, MCL 2-405, Toronto, ON M5T 2S8, Canada. E-mail: Frances.chung@uhn.ca Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2N1qqTy

Pediatric Otolaryngological Emergency: An Experience from a Tertiary Care Teaching Institution at Kolkata, India

Abstract

Otolaryngological conditions constitute a major share of emergency medical problem among children. The present study was conducted to assess the patient profiles, incidences morbidities, mode of presentation and managements of different otolaryngological emergencies among pediatric patients presented in a tertiary care hospital. Descriptive cross-sectional study by analysing retrospectively collected information pertaining to the patients attended ENT emergency service department of a tertiary care hospital, Kolkata. Data were collected using predesigned proforma and were analysed with the help of SPSS version 20. About 39.0% of total ENT emergency attendance was contributed by pediatric age group. The male female ratio was 1:1.33 with average age of 58.95 ± 34.42 (mean ± SD) months. Half of the attendees had ear problem and almost one-third reported complaints related to nose. The major complaints at the time of presentation were earache (32.3%), nasal foreign body (24.0%) and aural foreign body (13.3%) closely followed by aero-digestive tract foreign body (12.0%). Inflammatory conditions affected the ears more, foreign bodies found most commonly in nose and miscellaneous condition such as impacted wax was found to be related to ear in significantly higher proportion. Conservative management was provided to 96.25% of patients. Foreign body insertion was found to be associated with lower age group. Most of the emergencies were managed conservatively which might be done at subdivision or district level to reduce the undesirable burden on the tertiary care medical colleges.

https://ift.tt/2MfFacc

Ossifying Fibroma of Maxilla in a Female Affected by Neurofibromatosis Type 1

Abstract

Ossifying fibroma is a benign fibro-osseous lesion found exclusively in jaws. It has a predilection for premolar–molar region in the mandible. The occurrence of OF as solitary lesions with no underlying disease is common in jaws. However its co-existence in patients with neurofibromatosis type 1 (NF1) has not been described in jaws. NF1, also known as von Recklinghausen's disease or peripheral neurofibromatosis, is an autosomal dominant multisystem disorder that approximately affects 1 in 2500–3000 births. The common manifestations of this disease include Café-au-lait macules, skinfold freckling, cutaneous neurofibromas, blue-red and pseudoatrophic macules on skin, plexiform neurofibroma, scoliosis, optic glioma. So far only one case of ossifying fibroma (OF) in such patients has been reported in the skull but not in the maxillofacial region. We report a case of OF of the maxilla in a 45 year old female suffering from NF1. To the best of our knowledge this is the first case report where OF occurred in the maxilla in patient with NF1.

https://ift.tt/2wZmsAH

Ahila’s Diathermy Round Knife for Endoscopic Ear Surgery

Abstract

As endoscopic ear surgery is evolving day by day there is a constant need for improvisation in terms of instrumentation, visualization and clear bloodless surgical field. The applications of Ahila's Diathermy Round Knife for Endoscopic Ear Surgery are presented. The development of Ahila's diathermy round knife will prevent shifting to two handed ear surgery or the need for Endo holders. This new instrument is a game changer in endoscopic ear surgery creating a clean incision and bloodless field to operate. Surgical Instruments represent a major financial asset to the healthcare facility. Careful attention to care, handling and sterilization is essential to avoid costly replacements, enhance patient and surgeon satisfaction, reduce costs and delays in the Operating room and enhance patient safety. Ahila's round diathermy knife may facilitate the performance of surgery and advance the art of Endoscopic surgery to a higher level.

https://ift.tt/2Oa7bU0

Cystic Myoepithelioma of Parapharyngeal Space

Abstract

Myoepitheliomas are rare tumours of salivary glands arising from myoepithelial cells, which are normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane. The most common site of origin of Myoepitheliomas are the salivary glands and rarely other sites in the head and neck have been described in literature. Myoepithelioma arising from parapharyngeal space provide both a diagnostic and therapeutic challenge. We present such a case and discuss its diagnostic and therapeutic aspects.

https://ift.tt/2x19eDv