Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study

Background BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and a comprehensive analysis of specific risk factors are lacking. Methods We analyzed data of 313 patients in the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry, with an observation period of 3.3 years (range, 1 – 5). The net state of immunosuppressive therapy was assessed by the modified Vasudev score. Results Presumptive BKPyVAN (defined as sustained (>3 weeks) high-level BK viremia >104 copies/mL) within 5 years posttransplant occurred in 49/311 (15.8%) of patients, and biopsy-proven BKPyVAN in 14/313 (4.5%). BKPyV viremia was observed in 115/311 patients (36.7%), of whom 11 of 115 (9.6%) developed viremia late, ie, after the second year posttransplant. In 6/48 patients (12.5%) with high-level viremia and in 3/14 (21.4%) with BKPyVAN this respective event occurred late. According to multivariable analysis, BKPyV viremia and/or BKPyVAN were associated with a higher net state of immunosuppression (OR 1.3, p

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Islet Allotransplantation in the Bone Marrow of Patients With Type 1 Diabetes: A Pilot Randomized Trial

Background Results in murine and nonhuman primate suggested that the bone marrow (BM) might be an alternative site for pancreatic islet transplantation. Methods We report the results of 2 clinical studies in patients with type 1 diabetes receiving an intra-BM allogeneic islet transplantation: a feasibility study in patients with hepatic contraindications for liver islet allotransplantation receiving a single intra-BM islet infusion (n=4) and a pilot randomized trial (1:1 allocation using blocks of size 6) in which patients were randomized to receive islets into either the liver (n=6) or BM (n=3) to evaluate islet transplant function and survival Results We observed no adverse events related to the intrabone injection procedure or the presence of islets in the BM. None of the recipient of an intra-BM allogeneic islet transplantation had a primary nonfunction, as shown by measurable post transplantation C-peptide levels and histopathological evidence of insulin-producing cells or molecular markers of endocrine tissue in BM biopsy samples collected during follow-up. All patients receiving islets in the BM except one lost islet function during the first 4 months after infusion (2 with an early graft loss). Based on biopsies and immuno-monitoring, we concluded that the islet loss was primarily caused by the recurrence of autoimmunity. Conclusion BM is not a suitable alternative site for pancreatic islet allotransplantation in patients with type 1 diabetes Correspondence to: Lorenzo Piemonti, Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan. Fax: 39 02 26432871. Tel: 39 02 26432706. E-mail: piemonti.lorenzo@hsr.it Trial registration. ClinicalTrials.gov NCT01345227 and NCT01722682 Authorship page P.M. and A.S. managed patients. M.P. and C.D performed the histopathological analysis of the bone marrow. R.N., R.M. and A.M. performed islet isolations. V.S. and S.P performed the molecular analysis of the bone marrow biopsy samples. M.S. reviewed and edited the manuscript and contributed to the discussion. J.P., C.M. and F.C. developed the intrabone marrow islet infusion method and performed the transplantations. P.M., S.B., B.R, A.N. and M.C. performed the cellular and humoral immunomonitoring. L.P. conceived the intrabone marrow strategy, developed the concept, designed the experiments, wrote the manuscript, promoted the study, and researched data. L.P. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Disclosure The authors of this manuscript have no conflicts of interest to disclose as described by Transplantation. Funding This study was supported by the Italian Minister of Health (Ricerca Finalizzata RF-2009-1469691) and by the European Commission (FP7 241883 and H2020 681070). P.M. is supported by a Career Development Award (5-CDA-2015-85-A-N) from JDRF. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Migrating From Universal to Personalized Prevention: Predicting the Risk of Cytomegalovirus Infection after Organ Transplantation

No abstract available

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Outcomes in Third and Fourth Kidney Transplants Based on the Type of Donor

Background An increasing number of patients are requiring multiple retransplants. We assessed outcomes of third and fourth kidney transplants, to aid decision-making on the most suitable donor type. Methods Data were collected retrospectively for 2561 transplants, including 69 third and 8 fourth, performed from 2000-2017. Demographics and outcomes for the combined third/fourth group were compared to first and second transplants. Within the third/fourth kidney transplant group, comparisons were made between deceased-donors (n=39), live-donor-HLA-compatible (n=23) and -incompatible (n=13) transplants, as well as between standard (n=25) and extended-criteria (n=14) deceased-donor transplants. Results Patient survival did not differ significantly by transplant number (p=0.532), whilst death-censored graft survival declined progressively, from 89% at 5 years in first, 85% in second and 74% in the third/fourth transplant group (p

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Obesity and Metabolic Syndrome in Kidney Transplantation: The Role of Dietary Fructose and Systemic Endotoxemia

Background The concepts that obesity is merely a consequence of overeating, and that metabolic health then reflects obesity, may be insufficient and potentially flawed. The role of fructose intake and metabolic endotoxemia have gained attention recently, but data in kidney transplantation are lacking. This study evaluated the risk factors for metabolic syndrome (MS), its components, and other associated markers in kidney transplant recipients (KTRs), focussing particularly on fructose intake and systemic endotoxemia. Methods This cross-sectional observational study enrolled 128 KTRs>1-year posttransplantation. Clinical, biochemical, anthropometric, and questionnaire assessments were undertaken. Results Obesity (body mass index≥30kg/m2) and MS (International Diabetes Federation Definition) were found in 36.7% and 50% of KTRs respectively. Both increased fructose intake (p=0.01) and endotoxin level (p=0.02) were independently associated with MS; and higher fructose intake was independently associated with obesity (p0.6), as well as relationships between increased fructose intake, inflammation and blood glucose (r>0.6). Conclusions Dietary modifications through decreasing fructose intake and addressing systemic endotoxemia are plausible targets for improving metabolic health of KTRs. Corresponding Author: Dr Richard Borrows, Department of Nephrology & Kidney Transplantation, Area 5, Level 7, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK. Tel: +44 (0) 121 371 6099, Fax: +44 (0) 121 371 5858. Email: Richard.Borrows@uhb.nhs.uk Author Contributions Winnie Chan and Richard Borrows designed the research. Winnie Chan, Byron Smith, Mark Stegall, and Richard Borrows wrote the manuscript. Winnie Chan and Richard Borrows conducted the research. Winnie Chan, Byron Smith, and Richard Borrows analysed the data and performed the statistical analysis. Richard Borrows had primary responsibility for the final content. Disclosure: The authors declare no conflict of interest. Funding Winnie Chan received a research grant from the British Renal Society and was awarded a PhD research training fellowship from the National Health Service West Midlands Strategic Healthy Authority. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Fosfomycin-Trometamol for Urinary Tract Infections in Kidney Transplant Recipients

Background The treatment of urinary tract infections (UTI's) in kidney transplant recipients (KTRs) with oral antibiotics is complicated by increasing resistance to trimethoprim-sulfamethoxazole, amoxicillin/clavulanic acid and ciprofloxacin. Fosfomycin-trometamol (FT) could be an alternative, but evidence on clinical effectiveness is scarce. We evaluated the use, effectiveness and safety of FT for UTI in KTRs. Methods Data were retrospectively collected in 2 Dutch transplant hospitals from adult KTRs that were treated with FT as initial treatment for lower-UTI or asymptomatic bacteriuria or as stepdown treatment for upper-UTI after initial intravenous antibiotics. Exclusion criteria were in vitro resistance to FT or concomitant antibiotic treatment. Endpoints were clinical cure within 14 days and severe clinical failure, microbiological cure, relapse, recurrence, and acquired resistance within 90 days postend of treatment. Results 53 episodes in 40 KTRs were included (ASB n=15; lower-UTI n=33; upper-UTI n=5). FT was used for a median short duration in a heterogeneous gift interval. FT resulted in microbiological cure in 25, 28 and 100% of ASB, lower-UTI and upper-UTI with initial positive culture and follow-up culture performed, respectively. Clinical cure rates were 67% for lower-UTI and 80% for upper-UTI. Relapses or recurrences occurred in 31% and 24% of symptomatic UTI episodes, without severe clinical failure. Acquired resistance to fosfomycin was observed in 6 episodes. Conclusions FT has a reasonable effectiveness as last-resort oral treatment for lower-UTI and stepdown treatment for upper-UTI in KTRs. Randomized controlled trials with optimal dosage regimens are warranted. Use of FT is not recommended for ASB. Authorship: TD, HW, SM, JS and MB participated in the research design. TD and JS participated in the collection of the data. TD and HW participated in the data analysis. All authors participated in the writing of the paper. Disclosure: The authors declare no conflicts of interest. Funding: No funding was received for this work. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Serum Factor V is a Continuous Biomarker of Graft Dysfunction and a Predictor of Graft Loss After Liver Transplantation

Background: Factor V has never been compared to a validated early allograft dysfunction (EAD) definition. We aimed to assess Factor V as a biomarker of EAD and a predictor of graft loss after liver transplantation (LT). Methods: We retrospectively assessed the serum Factor V levels on postoperative day 1 after LT. Patients were divided according to their Factor V levels into the ≤36.1U/mL and >36.1U/mL groups. The primary outcome was graft loss within 1, 3, and 6 months. The secondary outcome was EAD, as defined by Olthoff et al Predictors of outcomes were identified by multivariable logistic regression. Results: 227 patients were included in the study: 74 with Factor V ≤36.1U/mL and 153 with Factor V >36.1U/mL. EAD was diagnosed in 41/74 (55.4%) patients with Factor V ≤36.1U/mL and in 20/153 (13.1%) patients with Factor V >36.1U/mL (p36.1U/mL (p=0.001). Factor V was a continuous predictor for 3- and 6-month graft loss [(OR=0.96 (95%CI 0.94–0.99) and OR=0.97 (95% CI 0.94–0.99) per U/mL], whereas EAD was not significant when adjusted for Factor V. Conclusion: Factor V is an early marker for EAD and is a continuous predictor of short-term graft loss after LT. Corresponding Author: Dr. Cleber Rosito Pinto Kruel, Assistant Professor, Liver Transplant Program, Hospital de Clinical de Porto Alegre, 2350 Ramiro Barcelos Street, office 745, Porto Alegre, Brazil, Phone: +55 51 3359 8232. E-mail: crkruel@hcpa.edu.br Authorship: AG has contributed to the study's concept, design, data collection, data analysis, interpretation, and manuscript writing. CP and JEP have contributed to the data collection and approved the manuscript's final version. MFC, ANB, AA, TJMG, IL, ADC, and MRAS have all contributed to the data interpretation and critical appraisal, and they also approved the manuscript's final version. GS and CRPK have contributed to the study's concept, design, data interpretation, and manuscript writing. All authors have approved the manuscript's final version. Category of manuscript: Original investigation Financial Support: None Conflict of Interest: None Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Temporal Changes in the Impact of HLA Mismatching Among Pediatric Kidney Transplant Recipients

Background Allocation for pediatric deceased-donor kidney transplantation (pDDKT) in the United States now deemphasizes HLA matching to improve equality in access to transplantation, but other national systems still consider HLA matching due to concerns about graft survival. We hypothesized that the impact of HLA mismatching has decreased over time due to advances including improved immunosuppression. Methods Using SRTR data, we analyzed whether the association between the number of HLA mismatches and outcomes of first-time pDDKTs changed between 2 eras: 1995-2004 (N=2854) and 2005-2014 (N=4643). Results Between eras, the median number of mismatches increased from 4 to 5 (p

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CMV-specific Cell-Mediated Immunity at 3-month Prophylaxis Withdrawal Discriminates D+/R+ Kidney Transplants at risk of Late-onset CMV Infection Regardless the Type of Induction Therapy

Background Whether CMV-specific cell-mediated immunity (CMI) at prophylaxis cessation predicts D+/R+ kidney transplants (KTR) at risk of late-onset CMV infection after receiving distinct induction therapies is still not well characterized. Methods We prospectively assessed CMV-specific CMI predicting late-onset CMV infection at prophylaxis withdrawal and at earlier time-points, in 96 consecutive D+/R+ patients receiving either antiinterleukin 2-receptor antibody (anti-IL2RA; n=50) or rabbit antithymoglobulin (rATG; n=46). CMV-specific CMI was evaluated against CMV antigens (IE-1, pp65) using an IFN-γ ELISpot assay. Results 14/96(14.6%) patients developed late-onset CMV infection and 2/96(2.1%) displayed disease. At 3 months, CMV-specific CMI frequencies were significantly lower in patients developing late-onset CMV infection (p

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Factors Associated With Mortality and Response to Extracorporeal Photopheresis in Lung Allograft Recipients With Bronchiolitis Obliterans Syndrome

Background This study was designed to identify factors associated with clinical response to extracorporeal photopheresis (ECP) and mortality after ECP in lung allograft recipients with bronchiolitis obliterans (BOS). Methods FEV1 values obtained 6 months before (baseline) and 6 months after initiation of ECP were used to plot the linear relationship between FEV1 vs time before and after ECP. Response to ECP was assigned when a positive integer was derived after subtracting the baseline rate of decline from the rate of decline 6 months after ECP. Uni- and multivariate logistic regression analyses were used to identify demographic, treatment related factors or spirometric parameters and that may be associated with response to ECP or mortality at either 6 or 16 months after initiation of ECP. Results FEV1 just prior to ECP was associated with mortality (p=0.007) at 16 months after ECP initiation. An FEV1 ≤ 1.50L had a sensitivity of 87% and a specificity of 60% to identify patients who died within 16 months after ECP initiation. Patients whose FEV1 decline exceeded > 40 mL/month were 12 times more likely to have a response to ECP (p=0.0001). Patients whose decline in FEV1 before ECP was statistically significant (p40 mL/month) and statistical significance of the relationship between FEV1 vs time prior to ECP initiation. Therefore, earlier BOS detection and more timely implementation of ECP (ie, when FEV1 values > 1.5L) should be considered especially in patients with a more aggressive rate of decline of lung function. Correspondence: George Despotis, MD, Washington University School of Medicine, Department of Pathology & Immunology, Division of Laboratory & Genomic Medicine,425 S. Euclid Avenue, Campus Box 8118, Saint Louis, MO 63110. Email gjdespotis@wustl.edu Authorship Hope E. Karnes, MD, PhD: Participated in research design, performance of the research, writing of the paper, data analysis Emily I. Schindler, MD, PhD: Participated in research design, performance of the research, writing of the paper, data analysis Matt Morrell, MD: Participated in research design, performance of the research, writing of the paper, data analysis Ramsey R Hachem MD: Participated in research design, performance of the research, writing of the paper, data analysis Keith Berman, MPH, MPA: Participated in writing of the paper, data analysis Suresh Vedantham, MD: Participated in writing of the paper, data analysis Jeff Atkinson, MD: Participated in writing of the paper, data analysis Edward Spitznagel, PhD: Participated performance of the research, in writing of the paper, data analysis George Despotis, MD: Participated in research design, performance of the research, writing of the paper, data analysis Disclosure: Relationships with entities related to the topic are listed below: Hope E. Karnes, MD, PhD - None Emily I. Schindler, MD, PhD - None Matt Morrell, MD –Investigator for Investigator initiated grant from Therakos and Medicare for protocol Number CAG-00324R2 Ramsey Hachem, MD – Investigator for Investigator initiated grant from Therakos and Medicare for protocol Number CAG-00324R2, Served on advisory board for Theravance, Served on advisory board for Vectura, Serving on advisory board for Breath Keith Berman MPH, MBA: Consultant to Therakos and Barnes-Jewish Hospital Suresh Vedantham, MD – Investigator for Investigator initiated grant from Therakos and Medicare for protocol Number CAG-00324R2 Jeff Atkinson, MD - None Ed Spitznagel, PhD – Investigator for Investigator initiated grant from Therakos and Medicare for protocol Number CAG-00324R2 George Despotis, MD – Principle Investigator for Investigator initiated grant from Therakos and Medicare for protocol Number CAG-00324R2 Funding: No funding for the current work. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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The Effect of Histidine-Tryptophan-Ketoglutarate Solution (HTK) and University of Wisconsin Solution (UW): an Analysis of the Eurotransplant Registry

Background Both UW and HTK are currently used in the Eurotransplant region for preservation of liver allografts. Previous studies on their effect have led to a lot of discussion. This study aims to compare the effect of HTK and UW on graft survival. Methods First liver transplantations in recipients ≥18 years from 1.1.2007 until 31.12.2016 were included. Graft survival was compared for livers preserved with HTK and UW at 30 days, 1, 3 and 5-years. Multivariable analysis of risk factors was performed and outcome was adjusted for important confounders. Results Of all 10,628 first liver transplantations, 8,176 (77%) and 2,452 (23%) were performed with livers preserved with HTK and UW, respectively. Kaplan-Meier curves showed significant differences in graft survival between HTK and UW at 30 days (89% vs 93%, p=

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Contribution of Sociodemographic Factors to Different Engagement of Children in Peer Violence

Violence and Gender, Ahead of Print.


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Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study

Metabolic Syndrome and Related Disorders, Ahead of Print.


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Relationship Between Handgrip Strength and Nonalcoholic Fatty Liver Disease: Nationwide Surveys

Metabolic Syndrome and Related Disorders, Ahead of Print.


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High Body Mass Index Masks Body Composition Differences in Physically Active Versus Sedentary Participants

Metabolic Syndrome and Related Disorders, Ahead of Print.


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Patients with Benign Thyroid Diseases Experience and Impaired Sex Life

Thyroid, Ahead of Print.


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Follicular Thyroid Carcinoma: A Perspective

Thyroid, Ahead of Print.


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MicroRNA-222 Promotes Invasion and Metastasis of Papillary Thyroid Cancer Through Targeting Protein Phosphatase 2 Regulatory Subunit B Alpha Expression

Thyroid, Ahead of Print.


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Diagnostic difficulties of primary angiosarcoma of the breast: a case report

Angiosarcoma of the breast is a rare tumor, which may be primary or secondary to breast surgery or irradiation. It is characterized by polymorphic and nonspecific clinical and radiological features. A patholog...

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Unklare, symptomarme Raumforderung im Bereich des Oropharynx

Laryngo-Rhino-Otol
DOI: 10.1055/a-0664-9045

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

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FREE Public Health Forum – All are welcome

Thyroid Disease and You

…

Do you have any concerns about your thyroid function? Have you or a family member been diagnosed

with thyroid disease or have you noticed

a lump in your neck?

The American Thyroid Association and our Alliance Partners Invite Thyroid Patients and their Families to join us for the:

2018 ATA Alliance for Thyroid Patient Education Health Forum

Saturday, October 6, 2018
2:00 pm – 4:00 pm
Marriott Marquis
901 Massachusetts Ave NW – Tulip Room, 2nd Floor
Washington, DC

ATA Physician Members and our ATA Alliance Partners are available to meet with thyroid patients and their families during the forum. This program is free and open to the public, please register/confirm your participation here.

Who should attend?

Please come if you have questions, symptoms, or concerns about a thyroid problem. We invite anyone who has had an overactive or underactive thyroid, thyroiditis, a thyroid nodule, thyroid cancer, or a family history of thyroid problems or related d isorders, including rheumatoid arthritis, juvenile diabetes, or pernicious anemia. Free educational materials will be available for all.

Reservations requested. Walk-ins welcome. E-mail thyroid@thyroid.org with any questions or requests for additional information.

Flyer for printing, saving, and posting (PDF File, 232 KB)

 

 

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Thyroid® High-Impact Articles

FREE ACCESS through September 3, 2018.

Read now:

Latest Impact Factor: 7.557
The Official Journal of: American Thyroid Association^®

Early Determinants of Thyroid Function Outcomes in Children with Congenital Hypothyroidism and a Normally Located Thyroid Gland: A Regional Cohort Study
Carole Saba, Sophie Guilmin-Crepon, Delphine Zénaty, Laetitia Martinerie, Anne Paulsen, Dominique Simon, Caroline Storey, Sophie Dos Santos, Jeremie Haignere, Damir Mohamed, Jean-Claude Carel, and Juliane Léger  

Comparing the Prognostic Value of the Eighth Edition of the American Joint Committee on Cancer/Tumor Node Metastasis Staging System Between Papillary and Follicular Thyroid Cancer
Evert F.S. van Velsen, Merel T. Stegenga, Folkert J. van Kemenade, Boen L.R. Kam, Tessa M. van Ginhoven, W. Edward Visser, and Robin P. Peeters

The Prognostic Impact of Tumor Size in Papillary Thyroid Carcinoma is Modified by Age
Bryan Tran, David Roshan, Earl Abraham, Laura Wang, Natalia Garibotto, James Wykes, Peter Campbell, and Ardalan Ebrahimi

Predicting Malignancy in Thyroid Nodules: Radiomics Score Versus 2017 American College of Radiology Thyroid Imaging, Reporting and Data System
Jinyu Liang, Xiaowen Huang, Hangtong Hu, Yihao Liu, Qian Zhou, Qinghua Cao, Wei Wang, Baoxian Liu, Yanling Zheng, Xin Li, Xiaoyan Xie, Mingde Lu, Sui Peng, Longzhong Liu, and Haipeng Xiao

Apparent Hyperthyroidism Caused by Biotin-Like Interference from IgM Anti-Streptavidin Antibodies
Leo Lam, Warwick Bagg, Geoff Smith, Weldon Wai Chiu, Martin James Middleditch, Julie Ching-Hsia Lim, and Campbell Vance Kyle  

 

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Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Ahead of Print.


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Reply to Park et al.: Human ectoparasite transmission of plague during the Second Pandemic is still plausible [Biological Sciences]

In their letter, Park et al. (1) raise several concerns and question our conclusion (2) that human ectoparasites could have caused plague epidemics during the Second Pandemic. First, Park et al. (1) state that our study cannot provide evidence that human ectoparasite transmission was more likely than a mixed pneumonic...

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Reply to Sharp et al.: Psychological targeting produces robust effects [Social Sciences]

Sharp et al. (1) suggest that our original findings refute rather than support the effectiveness of psychological targeting (2, 3). We respectfully disagree for the following reasons. Sharp et al. (1) state that "If psychological targeting worked reliably, it should have been 100% effective in all five experiments" and that...

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Can the pH at the air/water interface be different from the pH of bulk water? [Physical Sciences]

A recent article in PNAS (1) reports stable pH gradients in aqueous phosphate buffer microdroplets based on the pH dependence of surface-enhanced Raman spectroscopy (SERS) signals from 4-mercaptobenzoic acid–functionalized gold nanoparticle pH probes. The probing SERS signals were a 1,470-cm−1 shift assigned to a COO− stretching and a 1,710-cm−1 shift...

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Psychological targeting [Social Sciences]

Psychological targeting of advertising using Facebook profiles has been a contentious issue of late. Researchers from Columbia University, Stanford University, University of Pennsylvania, and Cambridge University, but separate from Cambridge Analytica, report results suggesting that psychological targeting using Facebook is so effective that its use should be regulated (1). Here,...

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Reply to Colussi: Microdroplet interfacial pH, the ongoing discussion [Physical Sciences]

We thank Colussi for his interest (1) in our article "Aerosol microdroplets exhibit a stable pH gradient" (2). Over the course of many years, Colussi and his colleagues have made numerous contributions to our understanding of the complicated chemistry of the air/water interface, and one of the goals of our...

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Human ectoparasite transmission of the plague during the Second Pandemic is only weakly supported by proposed mathematical models [Biological Sciences]

Dean et al. (1) infer that human ectoparasites were the dominant mode of transmission of plague (Yersinia pestis) during the Second Pandemic by comparing models representing distinct transmission routes. The authors are to be commended for providing detailed information on their computational approach (2). However, due to inconsistent modeling choices...

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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death [Neuroscience]

Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death. The majority of affected individuals harbor a loss-of-function mutation in one allele of SCN1A, which encodes the...

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Correction for Wang et al., Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins [Corrections]

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for "Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins," by Qian Wang, Michael R. Diehl, Biman Jana, Margaret S. Cheung, Anatoly B. Kolomeisky, and José N. Onuchic, which was first published September 27,...

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Codon usage influences fitness through RNA toxicity [Systems Biology]

Many organisms are subject to selective pressure that gives rise to unequal usage of synonymous codons, known as codon bias. To experimentally dissect the mechanisms of selection on synonymous sites, we expressed several hundred synonymous variants of the GFP gene in Escherichia coli, and used quantitative growth and viability assays...

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Third DWF1 paralog in Solanaceae, sterol {Delta}24-isomerase, branches withanolide biosynthesis from the general phytosterol pathway [Plant Biology]

A large part of chemodiversity of plant triterpenes is due to the modification of their side chains. Reduction or isomerization of double bonds in the side chains is often an important step for the diversification of triterpenes, although the enzymes involved are not fully understood. Withanolides are a large group...

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DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation [Immunology and Inflammation]

Activated T cells undergo metabolic reprogramming and effector-cell differentiation but the factors involved are unclear. Utilizing mice lacking DUSP6 (DUSP6−/−), we show that this phosphatase regulates T cell receptor (TCR) signaling to influence follicular helper T (TFH) cell differentiation and T cell metabolism. In vitro, DUSP6−/− CD4+ TFH cells produced...

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Quantum control of phase fluctuations in semiconductor lasers [Applied Physical Sciences]

Few laser systems allow access to the light–emitter interaction as versatile and direct as that afforded by semiconductor lasers. Such a level of access can be exploited for the control of the coherence and dynamic properties of the laser. Here, we demonstrate, theoretically and experimentally, the reduction of the quantum...

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Casz1 controls higher-order nuclear organization in rod photoreceptors [Genetics]

Genome organization plays a fundamental role in the gene-expression programs of numerous cell types, but determinants of higher-order genome organization are poorly understood. In the developing mouse retina, rod photoreceptors represent a good model to study this question. They undergo a process called "chromatin inversion" during differentiation, in which, as...

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Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill [Biophysics and Computational Biology]

Influenza hemagglutinin (HA) mediates viral entry into host cells through a large-scale conformational rearrangement at low pH that leads to fusion of the viral and endosomal membranes. Crystallographic and biochemical data suggest that a loop-to-coiled-coil transition of the B-loop region of HA is important for driving this structural rearrangement. However,...

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Differential inhibition of pyramidal cells and inhibitory interneurons along the rostrocaudal axis of anterior piriform cortex [Neuroscience]

The spatial representation of stimuli in sensory neocortices provides a scaffold for elucidating circuit mechanisms underlying sensory processing. However, the anterior piriform cortex (APC) lacks topology for odor identity as well as afferent and intracortical excitation. Consequently, olfactory processing is considered homogenous along the APC rostral–caudal (RC) axis. We recorded...

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A data-driven computational model on the effects of immigration policies [Political Sciences]

Many scholars suggest that visa restrictions push individuals who would have otherwise migrated legally toward illegal channels. This expectation is difficult to test empirically for three reasons. First, unauthorized migration is clandestine and often unobservable. Second, interpersonal ties between migrants and would-be migrants form a self-perpetuating system, which adapts in...

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Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons [Genetics]

Isolated congenital asplenia (ICA) is the only known human developmental defect exclusively affecting a lymphoid organ. In 2013, we showed that private deleterious mutations in the protein-coding region of RPSA, encoding ribosomal protein SA, caused ICA by haploinsufficiency with complete penetrance. We reported seven heterozygous protein-coding mutations in 8 of...

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The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites [Biochemistry]

Crystal structures of the neurotransmitter:sodium symporter MhsT revealed occluded inward-facing states with one substrate (Trp) bound in the primary substrate (S1) site and a collapsed extracellular vestibule, which in LeuT contains the second substrate (S2) site. In n-dodecyl-β-d-maltoside, the detergent used to prepare MhsT for crystallization, the substrate-to-protein binding stoichiometry...

https://ift.tt/2PtjgF8

Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling [Neuroscience]

Extending superresolution fluorescence microscopy to living animals has remained a challenging frontier ever since the first demonstration of STED (stimulated emission depletion) nanoscopy in the mouse visual cortex. The use of fluorescent proteins (FPs) in in vivo STED analyses has been limiting available fluorescence photon budgets and attainable image contrasts,...

https://ift.tt/2PthX91

Structure of the EmrE multidrug transporter and its use for inhibitor peptide design [Biophysics and Computational Biology]

Small multidrug resistance (SMR) pumps represent a minimal paradigm of proton-coupled membrane transport in bacteria, yet no high-resolution structure of an SMR protein is available. Here, atomic-resolution structures of the Escherichia coli efflux-multidrug resistance E (EmrE) multidrug transporter in ligand-bound form are refined using microsecond molecular dynamics simulations biased using...

https://ift.tt/2Mu49gZ

Postoperative Rechtsstreitigkeiten bei Trägern von Cochleaimplantaten

Zusammenfassung

Hintergrund

Nach der Versorgung mit einem oder 2 Cochleaimplantaten (CI) ergeben sich oft weitere Probleme betreffend die Frage, welche Folgekosten die gesetzlichen Krankenversicherungen oder andere Kostenträger übernehmen müssen, z. B. im Rahmen der Eingliederungshilfe.

Zielsetzung/Fragestellung

Der Artikel gibt einen Überblick über Urteile der deutschen Sozialgerichte. Untersucht wurde, ob es sich für den einzelnen Patienten lohnt, den Klageweg zu beschreiten und mit welcher Verfahrensdauer gerechnet werden muss.

Material und Methoden

Ausgewertet wurden die beiden größten kommerziellen juristischen Datenbanken sowie die von der Sozialgerichtsbarkeit veröffentlichten Urteile. Suchparameter waren „Cochlear", „Cochlea", „Implant" und „Implantat". Die besprochenen Entscheidungen ergingen im Zeitraum zwischen 2002 und 2017.

Ergebnisse

Insgesamt wurden 13 Entscheidungen gefunden. Die Ergebnisse variierten je nach den Besonderheiten des Einzelfalls. Von den untersuchten Urteilen und Beschlüssen fielen 54 % positiv für den Patienten (Kläger) aus. Die Verfahren dauerten zwischen 0,2 Jahren (ab Klage, Antragsdatum hier nicht bekannt) und 6,11 Jahren.

Schlussfolgerung

Die Arbeit zeigt, dass ungewiss ist, ob nicht in direktem Zusammenhang mit der Operation bzw. der Nachsorge stehende Kosten erstattet werden oder nicht. Da jeder Fall im Prinzip einzigartig ist, variieren auch die Ergebnisse. Trotzdem wird empfohlen, im Falle der Ablehnung der Ansprüche nach sorgfältiger Abwägung den Klageweg zu beschreiten.

https://ift.tt/2PlPJx7

Lebensqualität nach funktionell-ästhetischer Septorhinoplastik in primärer Operation vs. in Revisionsoperation – eine monozentrische Studie

Zusammenfassung

Hintergrund

Subjektive Bewertungen der Lebensqualität haben als Ergebnisqualität in den letzten Jahrzehnten an Bedeutung gewonnen. Die Anzahl der prospektiven Studien zur Lebensqualitätsmessung mit krankheitsspezifischen Messinstrumenten ist überschaubar. Ziel war es, die Lebensqualität nach primärer und Revisionsseptorhinoplastik eines einzelnen Chirurgen in einem HNO(Hals-Nasen-Ohrenheilkunde)-Zentrum zu untersuchen.

Studiendesign und Untersuchungsmethoden

Präoperativ und mindestens ein Jahr postoperativ wurden 2 krankheitsspezifische Lebensqualitätsmessinstrumente eingesetzt: der ROE(„rhinoplasty outcome evaluation")- und der NOSE(„nasal obstruction symptome evaluation")-Score. Weitere Informationen, insbesondere Alter, Geschlecht und Voroperationen, wurden erfragt.

Ergebnisse

Es wurden 237 Patienten in die Studie eingeschlossen, 208 (87,8 %) weibliche, 29 (12,2 %) männliche. Das Durchschnittsalter lag bei 30,3 ± 8,9 Jahren, der durchschnittliche Beobachtungszeitraum bei 19,3 ± 7,4 Monaten. Alle Operationen wurden von demselben Chirurgen (F. R.) durchgeführt. Mit dem Messinstrument NOSE zeigte sich eine signifikante Verbesserung der Obstruktion im Gesamtkollektiv (präoperativ 49,8 ± 26,2, postoperativ 19,1 ± 21,3; p < 0,001), ohne signifikanten Unterschied in Bezug auf primäre vs. Revisionsoperation. Der ROE-Score verbesserte sich signifikant, beide Kollektive (primär und sekundär operierte) zeigten beide Kollektive eine signifikante Verbesserung nach der Intervention. Postoperativ fielen die Patienten mit einer Primärintervention durch eine signifikant höheren Lebensqualität (p < 0,001) auf.

Schlussfolgerung

Die krankheitsspezifische Lebensqualität nimmt nach primärer Septorhinoplastik wie nach Revisionsoperation signifikant zu. Der NOSE-Score stieg in beiden Interventionsgruppen postoperativ signifikant an.

https://ift.tt/2OSqi5i

Determination of optimum vitamin D3 levels for NK cell-mediated rituximab- and obinutuzumab-dependent cellular cytotoxicity

Abstract

Vitamin D3 (25-OH-D3) deficiency impairs rituximab-dependent cellular cytotoxicity and the outcome of patients with diffuse large B-cell and follicular lymphomas (DLBCL). Since the optimum 25-OH-D3 serum levels for NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) are unknown, we determined the 25-OH-D3 serum levels associated with maximum NK cell-mediated ADCC. CD20 antibody-loaded CD20⁺ B-cell lymphoma cell lines were cultured with NK cells and ADCC activity was determined by lactate dehydrogenase release assays. Using a newly developed formula, pre-defined 25-OH-D3 serum levels were achieved with high individual precision over a wide range. NK cells from 20 healthy individuals killed antibody-treated CD20⁺ lymphoma cells in a concentration- and E:T ratio-dependent manner with obinutuzumab displaying a stronger ADCC activity than rituximab. Maximum NK-cell activity and ADCC were observed at 65 ng/ml 25-OH-D3, the middle of the normal range (30–100 ng/ml). 25-OH-D3 serum levels around this range should be the target in interventional trials aiming at improving NK cell-mediated ADCC by 25-OH-D3 substitution. Lower levels do not provide significant ADCC improvements in individuals with 25-OH-D3 deficiency or insufficiency and might result in the failure of interventions with 25-OH-D3.

https://ift.tt/2OVWCUJ

Hearing preservation in children with electric-acoustic stimulation after cochlear implantation

Abstract

Background

Cochlear implantation in patients with functional residual low-frequency hearing is performed according to an established hearing-preserving surgical technique in order to cause minimal trauma of inner ear structures. Due to the increasing number of cochlear implants in children, the preservation of residual hearing is becoming increasingly important in this patient collective.

Objectives

Short- and mid-term hearing preservation outcome in pediatric patients is investigated.

Materials and methods

A group of 9 children (12 ears) between 5 and 12 years of age were examined after hearing-assisted cochlear implantation with respect to the pure tone audiometric thresholds. Retrospectively, short-term hearing preservation (up to 3 months after surgery) was examined. In a subgroup of 5 children, mid-term hearing preservation (7.5 to 16 months after surgery) was also analyzed. The mean values of hearing preserved (HL%) and hearing loss (HL) due to electrode insertion were calculated as measured values.

Results

In the whole group, the mean values of the preoperative PTA_low were 29.8 dB and the short-term postoperative PTA_low 42.6 dB. The mean value of the HL% was 73.6%, corresponding to an HL of 9.4 dB. In the subgroup, the mean PTA_low postoperatively was 46.0 dB in the mid-term and the HL% at 80.7% with a HL of 6.6 dB.

Conclusions

The results in children are consistent with the results in adults. Electric-acoustic stimulation (EAS) should be used in the treatment of children with existing low-frequency residual hearing, as good residual hearing preservation can also be achieved in children after implantation.

https://ift.tt/2nXHOJY

Operative Therapie von Lidtumoren

Zusammenfassung

Tumoren der Lider sind oft Hauttumoren, sie können jedoch ihren Ursprung auch in anderen adnexalen Strukturen oder in der Konjunktiva haben. Die Therapie v. a. maligner Prozesse ist primär chirurgisch; hierbei wird die komplette Exzision zur Minimierung der Lokalrezidivrate angestrebt. In besonderen Fällen spielen adjuvante Therapien oder konservative Therapiealternativen (z. B. Radiatio, Kryotherapie, Immunmodulatoren) eine Rolle. Die Wiederherstellung der Lider hat die funktionelle und die ästhetische Rehabilitation zum Ziel. Im vorliegenden Beitrag werden Prinzipien und grundlegende Techniken für die Rekonstruktion der Periokularregion dargestellt.

https://ift.tt/2LekkJA

Long-Term Outcomes after Performing Tympanoplasty without Mastoidectomy for Active and Inactive Noncholesteatomatous Chronic Otitis Media

Objective: This study aimed to assess long-term outcomes after performing tympanoplasty without mastoidectomy (TWOM) for active and inactive noncholesteatomatous chronic otitis media (COM) and to estimate the optimal time for surgery. Methods: The patients were placed into an active ear group (group A) and an inactive ear group (group B). All patients were followed up for 5 years after TWOM. Results: Ninety-two cases among 113 achieved dry ears in half a month to 1 month. The tympanic pressure gradually improved 3–6 months after the operation. A total of 69/72 ears achieved dry ears in the active ear group, and 37 ears had effective hearing improvement. In all, 40/41 ears achieved dry ears in the inactive ear group, and 20 ears had effective hearing improvement. There was no difference in the recurrence rate or hearing improvement in the two groups. Conclusion: With good quality control of the surgical treatment of TWOM, there are no differences in long-term outcomes in noncholesteatomatous COM in different chronic infection conditions.
ORL

https://ift.tt/2nUIMGB

A computer program for investigating transformation geometry concepts in musical and visual form: from theory to realisation

Purves, Ross M.; (2001) A computer program for investigating transformation geometry concepts in musical and visual form: from theory to realisation. Masters thesis (M.A), University of London (Institute of Education). Green open access

https://ift.tt/2w3eupD

Control of a ROV carrying an object

Anderlini, E; Parker, GG; Thomas, G; (2018) Control of a ROV carrying an object. Ocean Engineering , 165 pp. 307-318. 10.1016/j.oceaneng.2018.07.022 .

https://ift.tt/2LeGonf

Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis: The Future of Quantitative Analysis

Wu, X; Kim, GH; Salisbury, ML; Barber, D; Bartholmai, BJ; Brown, KK; Conoscenti, CS; ... Walsh, SLF; + view all Wu, X; Kim, GH; Salisbury, ML; Barber, D; Bartholmai, BJ; Brown, KK; Conoscenti, CS; De Backer, J; Flaherty, KR; Gruden, JF; Hoffman, EA; Humphries, SM; Jacob, J; Maher, TM; Raghu, G; Richeldi, L; Ross, BD; Schlenker-Herceg, R; Sverzellati, N; Wells, AU; Martinez, FJ; Lynch, DA; Goldin, J; Walsh, SLF; - view fewer (2018) Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis: The Future of Quantitative Analysis. American Journal of Respiratory and Critical Care Medicine 10.1164/rccm.201803-0444PP . (In press). Green open access

https://ift.tt/2MnzPEq

Texture analysis on diffusion tensor imaging: discriminating glioblastoma from single brain metastasis

Skogen, K; Schulz, A; Helseth, E; Ganeshan, B; Dormagen, JB; Server, A; (2018) Texture analysis on diffusion tensor imaging: discriminating glioblastoma from single brain metastasis. Acta Radiologica 10.1177/0284185118780889 . (In press). Green open access

https://ift.tt/2whGyVF

Uplink narrowband IoT data rate improvement: dense modulation formats or non-orthogonal signal waveforms?

Xu, T; Darwazeh, I; (2018) Uplink narrowband IoT data rate improvement: dense modulation formats or non-orthogonal signal waveforms? In: (Proceedings) IEEE 29th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PIMRC). IEEE (In press).

https://ift.tt/2w0sH6Q

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich's Ataxia Models

Abeti, R; Baccaro, A; Esteras, N; Giunti, P; (2018) Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich's Ataxia Models. Frontiers in Cellular Neuroscience , 12 , Article 188. 10.3389/fncel.2018.00188 . Green open access

https://ift.tt/2LfzG0n

Experimental Validations on Self Interference Cancelled Non-Orthogonal SEFDM Signals

Xu, T; Darwazeh, I; (2018) Experimental Validations on Self Interference Cancelled Non-Orthogonal SEFDM Signals. In: IEEE

https://ift.tt/2w0smB6

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Escaned, J; Ryan, N; Mejía-Rentería, H; Cook, CM; Dehbi, HM; Alegria-Barrero, E; Alghamdi, A; ... Götberg, M; + view all Escaned, J; Ryan, N; Mejía-Rentería, H; Cook, CM; Dehbi, HM; Alegria-Barrero, E; Alghamdi, A; Al-Lamee, R; Altman, J; Ambrosia, A; Baptista, SB; Bertilsson, M; Bhindi, R; Birgander, M; Bojara, W; Brugaletta, S; Buller, C; Calais, F; Silva, PC; Carlsson, J; Christiansen, EH; Danielewicz, M; Di Mario, C; Doh, JH; Erglis, A; Erlinge, D; Gerber, RT; Going, O; Gudmundsdottir, I; Härle, T; Hauer, D; Hellig, F; Indolfi, C; Jakobsen, L; Janssens, L; Jensen, J; Jeremias, A; Kåregren, A; Karlsson, AC; Kharbanda, RK; Khashaba, A; Kikuta, Y; Krackhardt, F; Koo, BK; Koul, S; Laine, M; Lehman, SJ; Lindroos, P; Malik, IS; Maeng, M; Matsuo, H; Meuwissen, M; Nam, CW; Niccoli, G; Nijjer, SS; Olsson, H; Olsson, SE; Omerovic, E; Panayi, G; Petraco, R; Piek, JJ; Ribichini, F; Samady, H; Samuels, B; Sandhall, L; Sapontis, J; Sen, S; Seto, AH; Sezer, M; Sharp, ASP; Shin, ES; Singh, J; Takashima, H; Talwar, S; Tanaka, N; Tang, K; Van Belle, E; van Royen, N; Varenhorst, C; Vinhas, H; Vrints, CJ; Walters, D; Yokoi, H; Fröbert, O; Patel, MR; Serruys, P; Davies, JE; Götberg, M; - view fewer (2018) Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes. JACC: Cardiovascular Interventions , 11 (15) pp. 1437-1449. 10.1016/j.jcin.2018.05.029 . Green open access

https://ift.tt/2LcSmhj

Design and operational strategies for good Indoor Air Quality in low-energy dwellings: performance evaluation of two apartment blocks in East London, UK

Burman, E; Shrubsole, C; Stamp, S; Mumovic, D; Davies, M; (2018) Design and operational strategies for good Indoor Air Quality in low-energy dwellings: performance evaluation of two apartment blocks in East London, UK. In: IBPC2018, 7th International Building Physics Conference. (In press).

https://ift.tt/2w15gtW

FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis

Chan Wah Hak, L; Khan, S; Di Meglio, I; Law, A-L; Häsler, SL-A; Quintaneiro, LM; Ferreira, APA; ... Boucrot, E; + view all Chan Wah Hak, L; Khan, S; Di Meglio, I; Law, A-L; Häsler, SL-A; Quintaneiro, LM; Ferreira, APA; Krause, M; McMahon, HT; Boucrot, E; - view fewer (2018) FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nature Cell Biology 10.1038/s41556-018-0146-8 . (In press).

https://ift.tt/2LcJcl9

Chidamide Combined With Cisplatin in Head and Neck Adenoid Cystic Carcinoma (HNACC)

Conditions:   Adenoid Cystic Carcinomas;   Chidamide;   Cisplatin
Intervention:   Drug: Chidamide combined with cisplatin
Sponsor:   Fudan University
Recruiting

https://ift.tt/2Bys7m0

Psychological Impact of a Sophrological Accompaniment During the Announcement of Thyroid Cancer

Condition:   Follicular Thyroid Cancer
Intervention:   Other: sophrology sessions
Sponsor:   Assistance Publique Hopitaux De Marseille
Not yet recruiting

https://ift.tt/2MDIQbL

Attachment Systems for Implant Overdenture

Conditions:   Dental Implants;   Dental Prosthesis Failure
Interventions:   Device: OT Equators® (Rhein83);   Device: Locator® (Zest)
Sponsor:   Rhein 83 Srl
Recruiting

https://ift.tt/2Ps9HGA

Study of Anlotinib Combined With Gemcitabine/Cisplatin in Advanced Nasopharyngeal Carcinoma

Conditions:   Recurrent Nasopharyngeal Carcinoma;   Metastatic Nasopharyngeal Carcinoma
Intervention:   Drug: Anlotinib plus gemcitabine/cisplatin
Sponsor:   Chinese Academy of Medical Sciences
Not yet recruiting

https://ift.tt/2NacKle

Modified Ramped Position for Intubation of Obese Females.

Conditions:   Obesity;   Anesthesia
Interventions:   Other: Modified ramped position;   Other: Ramped position
Sponsor:   Cairo University
Not yet recruiting

https://ift.tt/2PrQwwh

Single word test for the assessment of speech sound production in Persian speaking children: Development, reliability and validity

Publication date: Available online 21 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Akram Ahmadi, Abbas Ebadi, Mohammad Kamali, Talieh Zarifian, Mehdi Dastjerdi Kazemi, Reyhane Mohammadi

Abstract

Objectives

Single word tests are used frequently to determine clients' speech sound errors. These tools are user-friendly and popular for speech and language pathologists. The aim of this study was to design and validate a single word test for the assessment of speech sound production for Persian speaking children.

Methods

The present study included two phases. In phase I, test material was developed. Psychometric properties were evaluated in phase II. In the next phase, 525 typically developing Persian-speaking children with the age range of 3 to 5 years old were studied. Statistical Package for the Social Sciences, version 24.0 (SPSS, Inc., Chicago, IL) was used for statistical analysis of this study. The significance level was set at (p< 0.05).

Pilot study was performed by administrating the test on 25 typically developing children, construct validity: by administrating the test on 400 typically developing children and the comparison of performance of the children in 4 age groups (discriminative validity regarding age and by administration of this test and phonetic subtest of Persian version of diagnostic evaluation of articulation and phonology on 100 children (convergent validity). Inter-rater reliability was performed by transcription and scoring of samples of 25 children and calculation of Intra Correlation Coefficient (ICC) was calculated. Test-retest was completed by administrating the test two times on 100 children with two weeks intervals. Internal consistency was achieved by the calculation of the correlation of the items of test.

Results

The final version of the test includes 70 target words for assessment of the consonants in three positions, vowels in medial position and consonant clusters (CVCC). There was 80% or more than it for the percentage agreement between experts for the content validity. There wasn't any significant difference between experts' responses about items of the test.

4 pictures were revised based on children's responses for the pilot study. All of the reliability values (test-re test, internal consistency and inter-rater reliability) were higher than 0.85. There was a significant difference between the four age groups for the mean value of Persian single word test for speech sound production (p<0.0001). There was a high correlation between the score of this instrument and the scores of participants in the Phonetic sub-test of the Persian version of Diagnostic evaluation of articulation and phonology(r=0.934, p<0.0001).

Conclusion

It seems that the Persian Speech sound Production Test is a reliable and valid instrument that can be used to measure speech sound errors for Persian speaking children.

https://ift.tt/2LeT3qi

The impact of institutional clinical trial recruitment versus hospital volume on survival outcomes of patients with head and neck cancer: An analysis of the PET-NECK trial outcomes, UKCRN portfolio, and Hospital Episode Statistics (HES) in England

Publication date: October 2018

Source: Oral Oncology, Volume 85

Author(s): Daniel J. Lin, Christopher C. McConkey, Paul Nankivell, Janet Dunn, Hisham Mehanna

Abstract

Objectives

High institutional clinical trial recruitment and high hospital volume are reported to be independent indicators of better patient outcomes following cancer treatment. However, their relationship in head and neck cancers (HNC) remains less clear.

Methods

We aimed to assess the relationship between institutional clinical trial recruitment, hospital throughput of HNC cases, and survival of patients with advanced HNC treated with primary chemoradiotherapy at hospitals which recruited to the PET-NECK trial (2008–2012). The impact on outcome was assessed using Cox's proportional hazards regression analysis and multivariate analysis.

Results

HNC RCT recruitment positively correlated with hospital throughput (r = 0.57, p < 0.0001). Low-recruiters (1–5 patients) had a 107% increased risk of death when compared to high-recruiters (>5 patients) (HR = 2.07, p = 0.05). There was no significant impact of hospital throughput on overall or disease-specific HNC survival. Multivariate analysis identified p16 status, N-stage, smoking, and RCT recruitment volume as the only significant predictors of survival. There was a significant difference in chemotherapy regimen between low and high-recruiters (p = 0.003) where a higher proportion of patients (50%, n = 13) in low-recruiting compared to high-recruiting hospitals (29%, n = 92) received neoadjuvant chemotherapy. A higher proportion of these patients died at low-recruiting hospitals (46% versus 23%).

Discussion

A significant association exists between high recruitment and better OS for patients with HNC. However, no significance was found between hospital throughput and outcomes. The significance of individual centre differences in chemotherapy regimen needs further investigation. Future studies need a greater number of patient outcome events to support the trends found in this study.

https://ift.tt/2N6zBhx

PD-1/PD-L1 co-inhibition shapes anticancer T cell immunodominance: facing the consequences of an immunological ménage à trois

Abstract

PD-1- and PD-L1-blocking monoclonal antibodies have shown significant promise in clinical settings and rekindled the hope for successful cancer immunotherapy. We recently demonstrated that interfering with PD-1/PD-L1 signaling selectively augments CD8⁺ T cell (T_CD8) responses to subdominant determinants (SDDs) of a model tumor antigen. This was likely due to decreased lysis of SDD-specific T_CD8 by neighboring immunodominant clones co-engaging the same antigen-presenting cells (APCs). We therefore proposed that PD-1-based checkpoint inhibitors widen the range of tumor determinants that can be effectively targeted by T_CD8. Subsequently and using different tumor models, Chen et al. reported, in Proceedings of the National Academy of Sciences of the United States of America, that PD-L1 protects APCs from the lytic function of immunodominant T_CD8 and that PD-L1 blockade narrows, rather than broadens, the overall anticancer T cell response. Here, we briefly compare and contrast the experimental systems employed by the two groups, which may account, at least partially, for the opposing conclusions drawn. We argue that the pathway(s) of tumor antigen presentation, direct presentation versus cross-presentation, and the intensity of PD-1 expression by immunodominant and subdominant T_CD8 must be taken into consideration in rational design of anti-PD-1/PD-L1-adjuvanted tumor vaccines and therapies.

https://ift.tt/2BwtlhE

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

https://ift.tt/2L89HIl

Promoting and achieving excellence in the delivery of Integrated Allergy Care: the European Academy of Allergy & Clinical Immunology competencies for allied health professionals working in allergy

The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target...

https://ift.tt/2w3kQ8q

Kommentar zur Leitlinie „Implantierbare Hörgeräte“

https://ift.tt/2OTyBgX

Seltene Ursache einer zervikalen Schwellung

https://ift.tt/2nSOTvb

Age is a predictive factor in the femoral nerve positioning: an anatomical ultrasound study

Abstract

Precise identification of the femoral nerve (FN) is essential for an ultrasound-guided femoral nerve block. We hypothesized that the distance between the FN and the femoral artery (FA) is correlated with patient age. In this prospective observational study, we evaluated the FN–FA (from the lateral edge of the FA to the medial edge of the FN) distance [0.42 ± 0.42 (mean ± standard deviation) cm] in 102 patients using ultrasound. In addition, we calculated the cross-sectional area of the iliopsoas muscle using computed tomography or magnetic resonance imaging. Multiple regression analyses revealed that age was significantly and positively correlated with the FN–FA distance (R² = 0.72, p < 0.001) and that this correlation was greater than that between height, weight, or gender and the FN–FA distance. Further, the cross-sectional area of the iliopsoas muscle per weight was significantly correlated with age (R² = 0.54, p < 0.001) and the FN–FA distance (R² = 0.50, p < 0.001). These findings may help refine the ultrasound techniques used for the femoral nerve block.

https://ift.tt/2BtVMfY

Elevated total serum IgE in vitiligo might be protective for other autoimmune diseases

British Journal of Dermatology, EarlyView.


https://ift.tt/2N5SZez

MiR‐146a‐5p correlates with clinical efficacy in patients with psoriasis treated with the tumour necrosis factor‐alpha inhibitor adalimumab

British Journal of Dermatology, EarlyView.


https://ift.tt/2Pr9ymr

Epithelial Folliculin Enhances Airway Inflammation in Aspirin‐Exacerbated Respiratory Disease

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Prz0Iu

High and Low Dose Oral Immunotherapy Similarly Suppress Pro‐Allergic Cytokines and Basophil Activation in Young Children

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2N5qddX

Birch pollen specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL‐33 in mice

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PryIBo

Association of nasal microbiome and asthma control in patients with chronic rhinosinusitis

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Naz3qA

Case of amyloidosis cutis dyschromica with dermoscopy

The Journal of Dermatology, EarlyView.


https://ift.tt/2Le3jPC

Acquired digital arteriovenous malformation presenting as erythronychia

The Journal of Dermatology, EarlyView.


https://ift.tt/2w3bxp2

Ten‐year follow up of longitudinal melanonychia in childhood: A case report

The Journal of Dermatology, EarlyView.


https://ift.tt/2LeUzsF

Aesthetic reconstruction of extensive pubic keloids using bilateral modified keystone flaps

The Journal of Dermatology, EarlyView.


https://ift.tt/2w7obUj

Two Japanese families with hypohidrotic ectodermal dysplasia: Phenotypic differences between affected individuals

The Journal of Dermatology, EarlyView.


https://ift.tt/2ORNwIq

Are dermatologists who treat patients with delusional infestation at risk of major complaints and being stalked?

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2vZGXgf

Prevalence of HPV in Oral Squamous Cell Carcinoma in South West India

Abstract

There are inconsistent reports regarding the role of HPV in the origin and progression of oral squamous cell carcinoma (OSCC). The observed heterogeneity was mainly attributed to the social and cultural habits of the enrolled cases, discrepancies in the nature of samples procured and varying sensitivity of the assays employed for detection of HPV. The objective of this study was to assess the prevalence of HPV in OSCC in South West India. This was a cross sectional study conducted over a period extending from October 2015 to June 2017. This study involved Department of ENT-Head and Neck Surgery and Department of Virology, Manipal Academy of Higher Education. Fifty histologically confirmed oral squamous cell carcinoma patients undergoing wide local excision of the tumour were enrolled for the study. Intraoperatively 4–5 mm of tissue samples were transported in sterile normal saline at 4–80 °C. The primary screening of tissue samples was performed by nested PCR using PGMY09/11 consensus primers and GP5+/6+ consensus primers and TaqMan based real time multiplex PCR for HPV-16, HPV-18, HPV-31 and HPV-45. All samples tested negative for HPV DNA by conventional nested PCR and TaqMan based real-time Multiplex PCR ruling out four common HPV subtypes such as HPV-16, 18, 31, 45. We did not find presence of HPV DNA in the tissues of patients with OSCC from southwest India. However, studies with more geographic representation from other parts of India are required before generalising our findings.

https://ift.tt/2w0GdY2

A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self-Administered Questionnaires

Costedoat-Chalumeau, N; Houssiau, F; Izmirly, P; Le Guern, V; Navarra, S; Jolly, M; Ruiz-Irastorza, G; ... Isenberg, D; + view all Costedoat-Chalumeau, N; Houssiau, F; Izmirly, P; Le Guern, V; Navarra, S; Jolly, M; Ruiz-Irastorza, G; Baron, G; Hachulla, E; Agmon-Levin, N; Shoenfeld, Y; Dall'Ara, F; Buyon, J; Deligny, C; Cervera, R; Lazaro, E; Bezanahary, H; Leroux, G; Morel, N; Viallard, J-F; Pineau, C; Galicier, L; Van Vollenhoven, R; Tincani, A; Nguyen, H; Gondran, G; Zahr, N; Pouchot, J; Piette, J-C; Petri, M; Isenberg, D; - view fewer (2018) A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self-Administered Questionnaires. Clinical Pharmacology & Therapeutics 10.1002/cpt.1194 . (In press).

https://ift.tt/2PoauIq

Synergies of Spaceborne Imaging Spectroscopy with Other Remote Sensing Approaches

Guanter, L; Brell, M; Chan, JCW; Giardino, C; Gomez-Dans, J; Mielke, C; Morsdorf, F; ... Yokoya, N; + view all Guanter, L; Brell, M; Chan, JCW; Giardino, C; Gomez-Dans, J; Mielke, C; Morsdorf, F; Segl, K; Yokoya, N; - view fewer (2018) Synergies of Spaceborne Imaging Spectroscopy with Other Remote Sensing Approaches. Surveys in Geophysics 10.1007/s10712-018-9485-z . (In press).

https://ift.tt/2N1LuoH

Effects of creativity on social and behavioral adjustment in 7- to 11-year-old children

Fancourt, D; Steptoe, A; (2018) Effects of creativity on social and behavioral adjustment in 7- to 11-year-old children. Annals of the New York Academy of Sciences 10.1111/nyas.13944 . (In press). Green open access

https://ift.tt/2MGGM2H

Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study

Walsh, SLF; Wells, AU; Desai, SR; Poletti, V; Piciucchi, S; Dubini, A; Nunes, H; ... Hansell, DM; + view all Walsh, SLF; Wells, AU; Desai, SR; Poletti, V; Piciucchi, S; Dubini, A; Nunes, H; Valeyre, D; Brillet, PY; Kambouchner, M; Morais, A; Pereira, JM; Moura, CS; Grutters, JC; van den Heuvel, DA; van Es, HW; van Oosterhout, MF; Seldenrijk, CA; Bendstrup, E; Rasmussen, F; Madsen, LB; Gooptu, B; Pomplun, S; Taniguchi, H; Fukuoka, J; Johkoh, T; Nicholson, AG; Sayer, C; Edmunds, L; Jacob, J; Kokosi, MA; Myers, JL; Flaherty, KR; Hansell, DM; - view fewer (2016) Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study. The Lancet - Respiratory Medicine , 4 (7) pp. 557-565. 10.1016/S2213-2600(16)30033-9 . Green open access

https://ift.tt/2N875Mb

Physical properties and biocompatibility effects of doping SiO2 and TiO2 into phosphate-based glass for bone tissue engineering

Aldaadaa, A; Al Qaysi, M; Georgiou, G; Ma Leeson, R; Knowles, JC; (2018) Physical properties and biocompatibility effects of doping SiO2 and TiO2 into phosphate-based glass for bone tissue engineering. Journal of Biomaterials Applications , 33 (2) pp. 271-280. 10.1177/0885328218788832 . Green open access

https://ift.tt/2MF3ZTa

Completion lymphadenectomy should not necessarily be recommended after a positive sentinel lymph node biopsy

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Mq6qJR

Promoting prompt help-seeking for symptoms - assessing the impact of a gynaecological cancer leaflet on presentations to primary care: a record-based randomised control trial

Campbell, J; Vaghela, K; Rogers, S; Pyer, M; Simon, A; Waller, J; (2018) Promoting prompt help-seeking for symptoms - assessing the impact of a gynaecological cancer leaflet on presentations to primary care: a record-based randomised control trial. BMC Public Health , 18 , Article 997. 10.1186/s12889-018-5920-9 . Green open access

https://ift.tt/2Bv6zXh

Secukinumab‐induced paradoxical pustular psoriasis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2wl0J5g

On low-latency-capable topologies, and their impact on the design of intra-domain routing

Gvozdiev, N; Vissicchio, S; Karp, BN; Handley, M; (2018) On low-latency-capable topologies, and their impact on the design of intra-domain routing. In: Gorinsky, S and Tapolcai, J, (eds.) SIGCOMM '18: Proceedings of the 2018 Conference of the ACM Special Interest Group on Data Communication. (pp. pp. 88-102). Association for Computing Machinery Green open access

https://ift.tt/2PoGNad

Probing the Hidden Depths of Climate Law: Analysing National Climate Change Legislation

Scotford, EAK; Minas, S; (2018) Probing the Hidden Depths of Climate Law: Analysing National Climate Change Legislation. Review of European, Comparative and International Environmental Law (In press).

https://ift.tt/2N32PxD

Monoclonal gammopathy of undetermined significance and smoldering myeloma (SMM): a practical guide to management

Maciocia, N; Wechalekar, A; Yong, K; (2016) Monoclonal gammopathy of undetermined significance and smoldering myeloma (SMM): a practical guide to management. Hematological Oncology , 35 (4) pp. 432-439. 10.1002/hon.2345 . Green open access

https://ift.tt/2MDNpmx

Bronchiectasis in yellow nail syndrome

Woodfield, G; Nisbet, M; Jacob, J; Mok, W; Loebinger, MR; Hansell, DM; Wells, AU; Woodfield, G; Nisbet, M; Jacob, J; Mok, W; Loebinger, MR; Hansell, DM; Wells, AU; Wilson, R; - view fewer (2016) Bronchiectasis in yellow nail syndrome. Respirology , 22 (1) pp. 101-107. 10.1111/resp.12866 . Green open access

https://ift.tt/2Bvb8B1

Coherent diffraction study of calcite crystallization during the hydration of tricalcium silicate

Liu, X; Lin, W; Chen, B; Zhang, F; Zhao, P; Parsons, A; Rau, C; Liu, X; Lin, W; Chen, B; Zhang, F; Zhao, P; Parsons, A; Rau, C; Robinson, I; - view fewer (2018) Coherent diffraction study of calcite crystallization during the hydration of tricalcium silicate. Materials and Design , 157 pp. 251-257. 10.1016/j.matdes.2018.07.031 .

https://ift.tt/2MDNiHD

Evaluation of visual and computer-based CT analysis for the identification of functional patterns of obstruction and restriction in hypersensitivity pneumonitis

Jacob, J; Bartholmai, BJ; Brun, AL; Egashira, R; Rajagopalan, S; Karwoski, R; Kouranos, V; ... Wells, AU; + view all Jacob, J; Bartholmai, BJ; Brun, AL; Egashira, R; Rajagopalan, S; Karwoski, R; Kouranos, V; Kokosi, M; Hansell, DM; Wells, AU; - view fewer (2017) Evaluation of visual and computer-based CT analysis for the identification of functional patterns of obstruction and restriction in hypersensitivity pneumonitis. Respirology , 22 (8) pp. 1585-1591. 10.1111/resp.13122 . Green open access

https://ift.tt/2N32wTv

Giving up Control - A Speculative Air Pollution Mask to Reflect on Autonomy and Technology Design

Schulte, BF; Lechelt, Z; Singh, A; (2018) Giving up Control - A Speculative Air Pollution Mask to Reflect on Autonomy and Technology Design. In: Koskinen, I and Lim, Y-K and Cerratto-Pargman, T and Chow, KKN and Odom, W, (eds.) DIS '18: Companion Proceedings of the 2018 ACM Conference Companion Publication on Designing Interactive Systems. (pp. pp. 177-181). ACM: New York, USA. Green open access

https://ift.tt/2PlySKG

Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization

Keir, GJ; Wort, SJ; Kokosi, M; George, PM; Walsh, SLF; Jacob, J; Price, L; ... Wells, AU; + view all Keir, GJ; Wort, SJ; Kokosi, M; George, PM; Walsh, SLF; Jacob, J; Price, L; Bax, S; Renzoni, EA; Maher, TM; MacDonald, P; Hansell, DM; Wells, AU; - view fewer (2018) Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization. Respirology , 23 (7) pp. 687-694. 10.1111/resp.13250 .

https://ift.tt/2N32oU1

Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice

Schaarschmidt, B; Vlaic, S; Medyukhina, A; Neugebauer, S; Nietzsche, S; Gonnert, FA; Roedel, J; ... Press, AT; + view all Schaarschmidt, B; Vlaic, S; Medyukhina, A; Neugebauer, S; Nietzsche, S; Gonnert, FA; Roedel, J; Singer, M; Kiehntopf, M; Figge, MT; Jacobsen, ID; Bauer, M; Press, AT; - view fewer (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics , 8 (14) pp. 3766-3780. 10.7150/thno.24333 . Green open access

https://ift.tt/2PoGJat

Ultralow energy calibration of LUX detector using Xe-127 electron capture

Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Bailey, AJ; Balaithy, J; Beltrame, P; ... Zhang, C; + view all Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Bailey, AJ; Balaithy, J; Beltrame, P; Bernard, EP; Bernstein, A; Biesiadzinski, TP; Boulton, EM; Bras, P; Byram, D; Cahn, SB; Carmona-Benitez, MC; Chan, C; Currie, A; Cutter, JE; Davison, TJR; Dobi, A; Druszkiewicz, E; Edwards, BN; Fallon, SR; Fan, A; Fiorucci, S; Gaitskell, RJ; Genovesi, J; Ghang, C; Gilchriese, MGD; Hall, CR; Hanhardt, M; Haselschwardt, SJ; Hertel, SA; Hogan, DP; Horn, M; Huang, DQ; Ignarra, CM; Jacobsen, RG; Ji, W; Kamdin, K; Kazkaz, K; Khaitan, D; Knoche, R; Larsen, NA; Lenardo, BG; Lesko, KT; Lindote, A; Lopes, MI; Manalaysay, A; Mannino, RL; Marzioni, MF; McKinsey, DN; Mei, D-M; Mock, J; Moongweluwan, M; Morad, JA; Murphy, ASJ; Nehrkom, C; Nelson, HN; Neves, F; Neves, F; O'Sullivan, K; Oliver-Mallory, KC; Palladino, KJ; Pease, EK; Rhyne, C; Shaw, S; Shutt, TA; Silva, C; Solmaz, M; Solovov, VN; Sorensen, P; Sumner, TJ; Szydagis, M; Taylor, DJ; Taylor, WC; Tennyson, BP; Terman, PA; Tiedt, DR; To, WH; Tripathi, M; Tvrznikova, L; Uvarov, S; Velan, V; Verbus, JR; Webb, RC; White, JT; Whitis, TJ; Witherell, MS; Wolfs, FLH; Xu, J; Yazdani, K; Young, SK; Zhang, C; - view fewer (2017) Ultralow energy calibration of LUX detector using Xe-127 electron capture. Physical Review D , 96 (11) , Article 112011. 10.1103/PhysRevD.96.112011 . Green open access

https://ift.tt/2N4P2Xv

Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts

De, R; Verma, SS; Holzinger, E; Hall, M; Burt, A; Carrell, DS; Crosslin, DR; ... Gilbert-Diamond, D; + view all De, R; Verma, SS; Holzinger, E; Hall, M; Burt, A; Carrell, DS; Crosslin, DR; Jarvik, GP; Kuivaniemi, H; Kullo, IJ; Lange, LA; Lanktree, MB; Larson, EB; North, KE; Reiner, AP; Tragante, V; Tromp, G; Wilson, JG; Asselbergs, FW; Drenos, F; Moore, JH; Ritchie, MD; Keating, B; Gilbert-Diamond, D; - view fewer (2016) Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. Human Genetics , 136 (2) pp. 165-178. 10.1007/s00439-016-1738-7 . Green open access

https://ift.tt/2PrUAwz

Organizing health inequalities? Employee-driven innovation and the transformation of care

Halford, S; Fuller, A; Lyle, K; Taylor, R; (2018) Organizing health inequalities? Employee-driven innovation and the transformation of care. Sociological Research Online (In press). Green open access

https://ift.tt/2N4Wkug

Systematizing Genome Privacy Research: A Privacy-Enhancing Technologies Perspective

Mittos, A; Malin, B; De Cristofaro, E; (2019) Systematizing Genome Privacy Research: A Privacy-Enhancing Technologies Perspective. Proceedings on Privacy Enhancing Technologies (PoPETs) , 2019 (In press).

https://ift.tt/2MGgsWw

Tax Enforcement, Tax Compliance and Tax Morale in Transition Economies: A Theoretical Model

Bruno, RL; (2018) Tax Enforcement, Tax Compliance and Tax Morale in Transition Economies: A Theoretical Model. European Journal of Political Economy (In press).

https://ift.tt/2NawEw4

Prevalence of HPV in Oral Squamous Cell Carcinoma in South West India

Abstract

There are inconsistent reports regarding the role of HPV in the origin and progression of oral squamous cell carcinoma (OSCC). The observed heterogeneity was mainly attributed to the social and cultural habits of the enrolled cases, discrepancies in the nature of samples procured and varying sensitivity of the assays employed for detection of HPV. The objective of this study was to assess the prevalence of HPV in OSCC in South West India. This was a cross sectional study conducted over a period extending from October 2015 to June 2017. This study involved Department of ENT-Head and Neck Surgery and Department of Virology, Manipal Academy of Higher Education. Fifty histologically confirmed oral squamous cell carcinoma patients undergoing wide local excision of the tumour were enrolled for the study. Intraoperatively 4–5 mm of tissue samples were transported in sterile normal saline at 4–80 °C. The primary screening of tissue samples was performed by nested PCR using PGMY09/11 consensus primers and GP5+/6+ consensus primers and TaqMan based real time multiplex PCR for HPV-16, HPV-18, HPV-31 and HPV-45. All samples tested negative for HPV DNA by conventional nested PCR and TaqMan based real-time Multiplex PCR ruling out four common HPV subtypes such as HPV-16, 18, 31, 45. We did not find presence of HPV DNA in the tissues of patients with OSCC from southwest India. However, studies with more geographic representation from other parts of India are required before generalising our findings.

https://ift.tt/2w0GdY2