Radiotherapy for breast cancer associated with a cutaneous presentation of systemic mastocytosis—a case report and literature review

Abstract

Ionizing radiation therapy is a common adjuvant therapy for individuals undergoing surgery for breast cancer. There are many well-recognized acute and chronic cutaneous reactions that can vary in severity, course and duration. We present a rare cutaneous manifestation of systemic mastocystosis, in a 59-year-old female who underwent adjuvant radiotherapy following local excision of ductal carcinoma in situ.

https://ift.tt/2Ai3u95

Transmesenteric hernia with two mesenteric defects in an adult

Abstract

Transmesenteric hernia is a rare cause of small bowel strangulation in adults and, to our knowledge, no one has reported the existence of two mesenteric defects in an adult. Our patient was a 73-year-old Japanese woman who presented to our emergency department complaining of abdominal pain and nausea. Computed tomography with contrast enhancement revealed a closed loop obstruction in the pelvis, suggesting small bowel strangulation due to an internal hernia. The emergency exploratory laparotomy indicated a small bowel strangulation caused by a transmesenteric hernia. With the examination across whole parts of the mesentery, we identified another small defect. Both defects were closed by suture intraoperatively, and the patient's postoperative course was satisfactory. Searching for whole parts of the mesentery after the reduction of a hernia can help prevent the recurrence of internal hernias.

https://ift.tt/2TCXlNC

Intracystic papillary breast carcinoma in a male patient: a case report and review of literature

Abstract

Intracystic papillary carcinoma of the breast is a rare subtype of breast cancer accounting for approximately 0.5–1% of all breast carcinomas. To the best of our knowledge, the occurrence of this rare subtype of breast cancer in the male is even lower with less than 20 cases reported in the English literature over the past 30 years. We report a case of an elderly Asian male with intracystic papillary breast carcinoma who initially presented with a right sided breast lump for 4 months duration and his subsequent management. In addition, a review of similar cases in the English literature is included.

https://ift.tt/2Ai356z

Marijuana and head and neck cancer: an epidemiological review

Marijuana is the most widely used illicit substance in Canada. To date, no conclusive study has looked at the epidemiologic basis of marijuana use and head and neck cancer (HNC). Due to the imminent recreation...

https://ift.tt/2DG2GOX

Bacillus subtilis exopolysaccharide prevents allergic eosinophilia

https://ift.tt/2P0Hm8V

Eligibility of monoclonal antibody-based therapy for patients with severe asthma: a Canadian cross-sectional perspective

Based on immunologic phenotypes underlying asthma, use of monoclonal antibody based therapies is becoming the new standard of care for severe, corticosteroid refractory clinical symptoms. Patients may qualify ...

https://ift.tt/2PKwT6u

Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients

Abstract

Background

Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in.

Methods

177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases.

Results

The mean age of OTR was 52 years, the mean age at transplantation was 42.7 years, and kidney was the most common organ transplanted (72%). Skin lesions were found in 147 patients (83%). Cutaneous infections were seen in 106 patients (60%). Warts (30%) had the larger incidence and were associated with azathioprine (P = 0.026), cyclosporine (P = 0.006), and tacrolimus (P = 0.009). Superficial mycoses occurred in 16% of OTR, mostly onychomycosis, which was associated with tacrolimus (P = 0.040). Actinic keratosis (AK) occurred in 31% of patients and cutaneous tumors in 56%. Squamous cell carcinoma (SCC) was the most common tumor type affecting 36% of OTR (n = 64), with invasive SCC predominating over in situ SCC, whereas basal cell carcinoma (BCC) accounted for 17%. Both SCC and BCC were more numerous in patients' skin type I (P < 0.05). SCC was more frequent (36%) in combined kidney and liver recipients (P = 0.004), and BCC was associated with cyclosporine (P = 0.047). Inflammatory complications (acne, alopecia, hypertrichosis, and gingival overgrowth) were observed in 17.5% of patients.

Conclusions

Organ transplant recipients must be regularly evaluated by dermatologists, who should be alert to the onset of infections and skin (pre)malignant diseases in these patients.

https://ift.tt/2P0F0qB

Myiasis incidences reported in and around central province of Sri Lanka

Abstract

Background

Myiasis, or the invasion of living tissues of humans and other mammals by dipterous larvae, is considered the world's fourth most common travel‐associated skin disease after cutaneous larval migrants, pyodermas, and pruritic arthropod‐reactive dermatitis.

Method

The present study recorded the cause, anatomical position, and severity of the wounds of myiasis patients admitted to 11 hospitals located in the central region of Sri Lanka from

February 2016 to July 2017.

Results

Altogether, 28 myiasis incidences were noted within the study period. Of the total identified myiasis patients, nine were female while the remainder were male. The greatest number of patients was recorded from the Mawanella Base Hospital and Peradeniya Teaching Hospital (seven patients each). The ages of recorded patients ranged between 30 and 92 years with the average being 59.4 years. The greatest number of myiasis cases was diagnosed in wounds located in lower limbs (24). In addition, scalp, urogenital, and umbilical infestations were recorded. Eighteen out of the total patients had diabetes mellitus, and two patients suffered from filarial lymphedema. Psychiatric illnesses were a predisposing factor of larval infestation of six patients including the recorded scalp and two urogenital myiasis patients. Of the 28 myiasis cases, 27 were caused by the old world screwworm, Chrysomya bezziana Villeneuve (Diptera: Calliphoridae), and one by the blowfly, Chrysomya megacephala Fabricius (Diptera: Calliphoridae).

Conclusion

The awareness of patients with ulcers about this disease helps to decrease further risk of being infected by fly larvae.

https://ift.tt/2znWw2J

Drugs with a stigma: thoughts regarding a recent publication, “One of the Best Treatments for Alopecia Areata Remains Unpublished”

https://ift.tt/2OXyu3O

A retrospective review of patients with Kaposi's sarcoma in Botswana

Abstract

Background

Despite widespread antiretroviral coverage in Botswana, Kaposi's sarcoma (KS) remains among the most common malignancies. To date, adult KS in Botswana is not well characterized. The diagnosis relies on clinical suspicion that is often confirmed by histopathology given the implications of treatment; however, this poses a significant resource burden.

Methods

We conducted a retrospective review of the cohort of patients biopsied for possible KS at Princess Marina Hospital, the main dermatology referral site in Botswana, from September 2008 through June 2015 to describe the demographics, human immunodeficiency virus (HIV) characteristics, and clinical presentations of these patients. Histopathologic diagnoses were reviewed, and positive predictive value (PPV) was used to characterize the accuracy of clinical suspicion of KS.

Results

A total of 441 patients received 450 biopsies where KS was on the differential diagnosis, and 239 patients (54%) were ultimately diagnosed with KS. The KS cohort was more likely to be male (58% vs. 37%, P < 0.001), HIV positive (94% vs. 85%, P < 0.05), and have lower CD4 counts at the time of biopsy (274 cells/μl vs. 362 cells/μl, P < 0.05). The PPV of clinical suspicion of KS was 58%. When KS was not histopathologically diagnosed, clinically benign diseases were found in 17%, medically significant conditions requiring alternative therapies in 78%, and life‐threatening diseases in 5%.

Discussion

Our study reinforces the risk factors in development of KS. The poor PPV supports the important role of histology in KS diagnosis to both ensure appropriate treatment and prevent overtreatment. Improved accessibility to biopsy and augmentation of local dermatopathologic services would likely improve diagnostic accuracy and treatment.

https://ift.tt/2zn5s8w

Superficial granulomatous pyoderma in a patient with ulcerative colitis successfully treated with cyclosporine A

https://ift.tt/2P0vUKa

Prevalence of skin diseases among hospitals in the public healthcare system of a developing country

Abstract

Background

Skin diseases in the population are universal, common, and can cause significant economic burden. The impact of skin diseases in the national public healthcare system is complex and poorly studied. This study analyzes the prevalence of skin diseases in a hospital setting within the National Public Health System of Mexico and describes the main associated characteristics.

Methods

Information was obtained from the 2015 hospital discharge database of the public healthcare system of Mexico. Pathologies that result in a direct dermatological condition were included according to chapter XII of the Tenth Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD ‐ 10) and grouped according to the classification of the report, The burden of skin diseases in the United States.

Results

In 2015, a total of 9,230,968 hospital discharges were registered nationwide, of which 170,917 discharges (1.85%) reported a dermatological disease as the main diagnosis; five states account for 40.79% of the cases reported in Mexico. Half of all the cases corresponded to skin infections (32.08%, n = 54,843) and non‐cancerous skin growths (27.80%, n = 47,515), and 59.71% were adult patients between 18 and 65 years of age.

Conclusions

Understanding of the configuration of skin diseases in a hospital setting and public healthcare system is warranted to develop effective public policies and research for the development of effective, safe, high‐quality care processes for the main groups of identified diseases.

https://ift.tt/2zognz4

Glomulin gene c.157_161del mutation in a family with multiple glomuvenous malformations

https://ift.tt/2OXVQWJ

Cryosurgical management of basal cell carcinoma: in vivo follow‐up using reflectance confocal microscopy

https://ift.tt/2zpojjm

Cyclosporine‐induced toxic leukoencephalopathy in toxic epidermal necrolysis

https://ift.tt/2OYX83R

Blaschkoid blue vitiligo

https://ift.tt/2zoglaq

Judicial precedents associated with periungual warts in South Korea

https://ift.tt/2OZ2Z9x

Oral suplatast tosilate for the treatment of urticaria pigmentosa, skin lesion in mastocytosis

https://ift.tt/2zoDVDU

Diagnosis, anatomy, and electromyography profiles of 73 nonrecurrent laryngeal nerves

Abstract

Background

The purpose of this work was to compare methods of detecting nonrecurrent laryngeal nerves (NRLNs).

Methods

Specificity and sensitivity were compared in three NRLN detection methods: CT, electromyography (EMG), and A‐B point comparison.

Results

A total of 73 intraoperative pictures and 36 CT details of NRLNs are presented. Incidence of NRLN was 0.39%. Type I NRLN accounted for 50.7%, type IIA 45.2%, type IIB 4.1%. The NRLN median latency was 2.13 ms vs 3.00 ms median in an RLN control group (P < .001). When the threshold was set to 2.5 ms, EMG latency detection had 96.7% sensitivity and 91.6% specificity for detecting NRLN, and the A‐B point comparison algrithm had 97.3% sensitivity and 92.5% specificity. Combining EMG latency detection with A‐B point comparison achieved 100% sensitivity and specificity for detecting NRLN.

Conclusion

This is the largest series of NRLN presented in the literature. Latency shorter than 2.50 ms combined with the A‐B point comparison method is the ideal algorithm procedure for early NRLN identification.

https://ift.tt/2Tz4jTQ

Erratum to “Protective effect of an astaxanthin nanoemulsion against neomycin-induced hair-cell damage in zebrafish” [Auris Nasus Larynx 45 (2018) 20–25]

The publisher regrets that the abstract was missing in the original publication of this article.

https://ift.tt/2R3wecY

Metastasis of adenoid cystic carcinoma from a submandibular gland to the larynx

The present article discusses the first reported case of adenoid cystic carcinoma (ACC) metastasis from a submandibular gland to the larynx. Both treatments of distant metastasis of ACC and secondary laryngeal tumor are challenging. Despite its slow progression, ACC is associated with high rates of local recurrence, distant metastasis, and poor prognosis. Patients with secondary laryngeal cancer often have other concurrent metastatic lesions. Therefore, treatment selection should consider the biological behavior of the tumor and characteristics of the laryngeal lesion, along with the general condition and quality of life of the patient.

https://ift.tt/2PNtRON

A linear hypopigmented lesion on the forehead

https://ift.tt/2FBGMia

Ingenol mebutate for the treatment of anogenital condylomata acuminata

https://ift.tt/2r2jAzM

Late‐onset naevus of Ota: a case series of six patients

https://ift.tt/2FBYLVU

Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease

https://ift.tt/2qZYjGE

Ustekinumab use in patients with severe psoriasis co‐infected with hepatitis B and/or C

Abstract

Exacerbation or reactivation of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) in persons infected with psoriasis during treatment with biologics is a documented concern with use of tumor necrosis factor (TNF) inhibitors. Much less is known, however, about these risks in relation to newer biologic drugs including ustekinumab (interleukin (IL)‐12/23 inhibition).

This article is protected by copyright. All rights reserved.

https://ift.tt/2zp7UeM

Impact of Parental Asthma, Prenatal Maternal Asthma Control and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3‐Year Old Children

Abstract

Background

While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma, and the role of maternal asthma control in pregnancy on the risk for asthma in the child.

Objective

We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3‐year old children how prenatal and cord blood vitamin D status might affect this risk.

Methods

Data from 806 women, their partners (biologic fathers of the infant), and their children participated in the Vitamin D Antenatal Asthma Reduction Trail (VDAART, clinicaltrialsgov identification number NCT00920621) were used for this cohort analysis. The parental report of physician‐diagnosed asthma or recurrent wheeze in offspring was the main outcome. Weibull regression models for interval‐censored event times were used to estimate the main variables of interests and additional covariates on the outcome.

Results

The highest risk was observed among children with both parents being asthmatic relative to non‐asthmatic parents (aHR=2.30, 95%CI: 1.35‐3.84), and less so if only the mother was asthmatic (aHR=1.70, 95%CI: 1.17‐2.40). In the subset of children born to asthmatic mothers, the risk for asthma was higher in those who were born to mothers whose asthma was uncontrolled (aHR=1.60, 95%CI: 1.02‐2.54). Children whose mothers had sufficient vitamin D status (25Hydroxyvitamin D≥30 ng/mL) at early and late pregnancy and had cord blood vitamin D sufficiency demonstrated a lower risk of asthma/recurrent wheeze than children who had insufficient vitamin D status at birth (aHR=0.47, 95%CI: 0.27‐0.83).

Conclusion and Clinical Relevance

Careful attention to maternal asthma control, monitoring vitamin D status and correcting insufficiency at early pregnancy and maintaining the sufficiency status throughout pregnancy have potential preventive roles in offspring asthma or recurrent wheeze.

This article is protected by copyright. All rights reserved.

https://ift.tt/2qZy8QF

Therapie im Stadium IV des nichtkleinzelligen Lungenkarzinoms mit Treibermutation

Zusammenfassung

Hintergrund

Die systemische Therapie des nichtkleinzelligen Lungenkarzinoms (NSCLC) ändert sich aktuell fundamental und mit beeindruckender Dynamik. Patienten mit fortgeschrittener Erkrankung werden aufgrund von Biomarkeranalysen entweder mit Immuntherapie, einer Kombination aus Immun- und Chemotherapie oder mit genetisch stratifizierten Therapien behandelt. Eine besondere Herausforderung stellen erworbene Resistenzen dar. Das zunehmende Verständnis für die molekularen Ursachen der Resistenz ermöglicht die Entwicklung potenterer Inhibitoren.

Ziel

In diesem Review sollen der gegenwärtige Therapiestandard und die aktuellen Entwicklungen der zielgerichteten Therapien für fortgeschrittene NSCLC dargestellt werden.

Material und Methoden

Dieses Review basiert auf der Zusammenfassung und Interpretation von Publikationen zu präklinischen und klinischen Studien im Bereich der zielgerichteten Therapie des fortgeschrittenen NSCLC.

Ergebnisse und Diskussion

Zielgerichtete Therapien gegen aktivierende Mutationen im EGFR- und BRAF-Gen sowie ALK- und ROS1-Fusionen stellen bereits den Erstlinienstandard für etwa 15 % der Patienten mit fortgeschrittenen NSCLC dar. Diese Entwicklung hat in retrospektiven Auswertungen zu einem deutlich verlängerten Überleben in diesen Subgruppen geführt. Für weitere Aberrationen werden zielgerichtete Therapien entwickelt, sodass aktuell für etwa 30 % der Patienten eine zielgerichtete Therapieoption besteht. Inhibitoren der neuen Generation zeichnen sich durch eine hohe Wirksamkeit gegen Tumoren mit erworbener Tyrosinkinaseinhibitor(TKI)-Resistenz und bessere Verträglichkeit aus und werden zunehmend in Erstlinie eingesetzt. Um molekulare Ursachen zu verstehen und die wirksamste Therapie auszuwählen, nimmt die Rebiopsie in der Resistenz einen besonderen Stellenwert ein.

https://ift.tt/2zjUPU8

Oligometastatische Erkrankung des nichtkleinzelligen Lungenkarzinoms

Zusammenfassung

Hintergrund

Seit langer Zeit war bekannt, dass Patienten mit isolierten ZNS oder Nebennierenmetastasen einer potentiell kurativen Therapie zugeführt werden können. Diese Daten konnten in retrospektiven und z. T. prospektiven Studien bestätigt und auf weitere Organe ausgedehnt werden. Diese Erkenntnisse führten zur Definition eines neuen Stadiums M1b in der 8. UICC Klassifikation.

Methode

Eine selektive Literaturrecherche wurde durchgeführt.

Ergebnisse

Obgleich zum jetzigen Zeitpunkt Daten zum Gesamtüberleben noch nicht vorliegen, so ergibt sich aus den bisherigen prospektiven Daten ein einheitliches Bild, welches für die Anwendung von lokaltherapeutischen Maßnahmen in diesem Kontext spricht. Ungeklärt bleiben in diesen Studien jedoch noch die richtige Sequenz der Therapie, die Wahl der Behandlungsmodalitäten sowie die Bedeutung von Lymphknotenmetastasen. Das NSCLC metastasiert üblicherweise in die Leber, Lunge, Nebenniere, das Hirn sowie in die Knochen. Interessanterweise finden sich stark unterschiedliche klinische Verläufe in Abhängigkeit der Metastasenlokalisation und einem synchronen oder metachronen auftreten der Metastasen. Beim Vorliegen von Nebennierenmetastasen ist die solitäre ipsilaterale Manifestation mit den längsten Überlebensraten assoziiert. Zur Therapie der Nebennierenmetastase bieten sich sowohl die stereotaktische Bestrahlung als auch die chirurgische Resektion an. Standardtherapie bei Fehlen einer entsprechenden ALK(„anaplastic lymphoma kinase")- bzw. EGFR(„epithelial growth factor receptor")-Treibermutation stellt aktuell noch die platinhaltige Kombinationschemotherapie dar. Bei isolierten ZNS(zentrales Nervensystem)-Metastasen sollte Patienten eine stereotaktische Präzisionsstrahlentherapie oder eine Operation mit anschließender Tumorbettnachbestrahlung angeboten werden. Bei solitären Knochenmetastasen ohne Rückenmarkkompression bietet sich die lokal ablative Radiotherapie als durchaus gleichwertige und in vielen Fällen weniger langfristig körperlich einschränkende Therapiemaßnahme im Vergleich zu operativ-resezierenden Maßnahmen an.

https://ift.tt/2OYdt90

Aktueller Stand der Diagnostik und Therapie des nichtkleinzelligen Lungenkarzinoms (NSCLC) im Stadium III

Zusammenfassung

Basierend auf der ausgeprägten Heterogenität der Patientengruppen im Stadium III des nichtkleinzelligen Lungenkarzinoms („non-small-cell lung cancer", NSCLC) – trotz der etwas differenzierteren neuen 8. Stadieneinteilung der Union Internationale Contre le Cancer (UICC)/International Association for the Study of Lung Cancer (IASLC) – wird eine zunehmend individualisierte Therapie dieser Patienten notwendig. Die initiale interdisziplinäre Einschätzung der Operabilität ist ein wesentlicher Faktor für die Therapieselektion. Die kombinierte simultane Chemostrahlentherapie bleibt für die Mehrzahl der Patienten im Stadium III die Standardbehandlung. Dieser Behandlung sollte sich aber – basierend auf den eindeutig und klinisch relevant positiven Ergebnissen der PACIFIC-Studie – eine konsolidierende Behandlung mit Durvalumab über 12 Monate bei positiver PD-L1-Expression im Tumor anschließen. Für die interdisziplinär als potenziell operabel eingeschätzten Patienten werden weiter multimodale Behandlungsprotokolle unter Einschluss der Operation den Standard darstellen. Aufgrund der positiven Datenlage für die Immuntherapie beim NSCLC in der Gruppe der inoperablen Patienten ergeben sich nun zwangsläufig auch in den lokal begrenzten Stadien hochrelevante Chancen für eine Integration der Checkpointinhibition in den Therapiealgorithmus, welche zukünftig detailliert im Rahmen von prospektiven klinischen Studien analysiert werden sollten.

https://ift.tt/2zjUQHG

Off-Label Use of Phakic Intraocular Lens with a “Piggyback” Technique

Purpose: We report a case of a highly myopic pseudophakic patient who received off-label placement of a phakic intraocular lens (pIOL) via a "piggyback" technique, allowing the placement of an intraocular lens (IOL) in his fellow eye, resulting in improved visual acuity and emmetropia. Case Report: A 66-year-old, highly myopic, pseudophakic male with an IOL implant in his left eye was referred for second opinion for surgical options for his phakic right eye. Given the severe myopic status of both eyes, he received off-label placement of a posterior chamber pIOL with a piggyback technique for the pseudophakic left eye followed by standard cataract surgery and intraocular lens implantation in the right eye. For the left eye, uncorrected best visual acuity improved from 20/70 to 20/25. Conclusion: This case demonstrates the successful off-label use of a phakic IOL in a pseudophakic, highly myopic patient with a piggyback technique, resulting in improved visual acuity and ultimately allowing IOL placement in the fellow eye for emmetropia. This off-label use of pIOL can offer ophthalmologists an alternative option for pseudophakic patents with severe refractive error.
Case Rep Ophthalmol 2018;9:465–472

https://ift.tt/2TynU6I

Risk of psychiatric disorders in rosacea: A nationwide, population‐based, cohort study in Taiwan

Abstract

Rosacea has been reported to be associated with psychiatric disorders. Nevertheless, a nationwide study of the relationship between rosacea and comorbid psychiatric diseases in an Asian population has not been conducted. The aim of this study was to clarify the role of rosacea in the various psychiatric disorders by using a nationwide database in Taiwan. Data were obtained from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 7881 patients with rosacea and 31 524 age‐ and sex‐matched controls were enrolled. Patients with rosacea tended to have more coexisting psychiatric disorders. After adjusting for age, sex, comorbidity and residence/regions, the adjusted hazard ratio (HR) of psychiatric disorders for patients with rosacea was 2.761 (95% CI = 2.650–2.877, P < 0.001). Among them, the highest adjusted HR are phobic disorder and obsessive–compulsive disorder of 7.841 (95% CI = 7.526–8.170, P < 0.001) and 6.389 (95% CI = 6.132–6.657, P < 0.001), respectively. The National Health Insurance Research Database of Taiwan does not include the information about rosacea subtypes, severity and laboratory parameters. In conclusion, rosacea is related to various psychiatric disorders. In addition to anxiety and depression, patients are also at increased risk of phobic disorder and obsessive–compulsive disorder.

https://ift.tt/2OVGQJ5

Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Ian-James Malm, Lisa M. Rooper, Justin A. Bishop, Selmin Karatayli Ozgursoy, Alexander T. Hillel, Lee M. Akst, Simon R. Best

Abstract

Background

Laryngeal squamous cell carcinoma (LSCC) is strongly associated with tobacco use, but recent reports suggest an increasing incidence of LSCC in patients without traditional risk factors, suggesting an alternative etiology of tumorigenesis. The purpose of this study is to characterize this non-smoking population and to compare immunohistochemical markers in tumor specimens from non-smokers and smokers with LSCC.

Methods

A retrospective chart review of patients with LSCC at Johns Hopkins Hospital (JHH) was performed. A tissue microarray (TMA) was constructed with tumor specimen from non-smokers with stage and age-matched smokers and stained for a variety of immunologic and molecular targets.

Results

In the JHH cohort of 521 patients, 12% (n = 63) were non-smokers. Non-smokers were more likely to be <45 years old at time of diagnosis (OR 4.13, p = 0.001) and to have glottic tumors (OR 2.46, p = 0.003). The TMA was comprised of tumors from 34 patients (14 non-smokers, 20 smokers). Only 2 patients (6%) were human-papillomavirus (HPV) positive by high-risk RNA in situ hybridization (ISH). There was no correlation between smoking status and p16 (p = 0.36), HPV-ISH positivity (p = 0.79), phosphatase and tensin homolog (PTEN, p = 0.91), p53 (p = 0.14), or programmed death-ligand 1 (PD-L1, p = 0.27) expression.

Conclusions

Non-smokers with LSCC are more likely to be younger at the time of diagnosis and have glottic tumors than smokers with LSCC. In TMA analysis of stage and age-matched specimens from smoker and non-smokers with LSCC, the pattern of expression for common molecular and immunologic markers is similar. Further, HPV does not appear to be a major causative etiology of LSCC in either smokers or non-smokers in our cohort of patients.

https://ift.tt/2AfIlN7

Oral core-needle biopsy in the diagnosis of malignant parapharyngeal space tumors

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Renhui Chen, Qian Cai, Faya Liang, Peiliang Lin, Ling Chen

Abstract

Objective

To confirm the pre-treatment diagnosis of parapharyngeal space malignancy could aid the treatment plan.

Methods

For patients with suspected malignant parapharyngeal space tumors following preoperative imaging, oral biopsy was conducted for pathological diagnosis with the use of 22-G biopsy needles.

Results

A total of 11 patients were enrolled. There were three previously diagnosed cases of head and neck malignancy, and eight cases were newly diagnosed. The tumor diameters were in the range of 3 to 5.5 cm. Ten cases (90.9%) achieved positive results, of which eight cases (72.7%) obtained positive results with one puncture and two cases obtained positive pathological results with two punctures. One case did not obtain positive results with two punctures; open surgical resection was performed for this patient. There were no complications such as needle track implantation, heavy bleeding or neurological damage symptoms during the puncture process.

Conclusions

Oral biopsy is a minimally invasive, safe and effective technique for the diagnosis of parapharyngeal space tumors. It is easy to operate and could facilitate a comprehensive treatment plan for parapharyngeal space malignancies.

https://ift.tt/2TAsu4w

The risk factors for residual juvenile nasopharyngeal angiofibroma and the usual residual sites

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Zhuofu Liu, Wei Hua, Huankang Zhang, Jingjing Wang, Xiaole Song, Li Hu, Hanyu Lu, Dehui Wang

Abstract

Objective

Juvenile nasopharyngeal angiofibroma (JNA) is non-metastasizing but potentially locally destructive tumor of the nasopharynx. It can destroy the skull base and invade into the cerebrum. Surgical management is the primary standard but residual disease is always a risk factor. We aimed to determine the risk factors for residual disease and usual sites for these residual tumors.

Methods

The medical records of 131 patients (mean age 17.6 ± 6.8, range 9–71 years) with histologically proven JNA were retrospectively analyzed. The surgeries were all nasal endoscopic approaches, with or without assistant incision.

Results

The prevalence of residual disease was 16.8%. Risk factors associated with JNA recurrence included tumor stage, intraoperative bleeding, and the year in which the operation was performed. The pterygoid canal, pterygoid process, and pterygopalatine foramen were the most frequent locations for residual tumor.

Conclusion

Surgical management should take particular care for the pterygoid canal, petrygoid process, and pterygopalatine foramen. Contrast-enhanced CT and MRI are effective tools to evaluate complete JNA excision in the first two days after primary surgery. Careful exploration of these areas may be the key to avoid residual JNA.

https://ift.tt/2AcU7b0

Is there any effect of anxiety and depression scores on the improvement of tinnitus after surgery in chronic otitis patients with tinnitus

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Resit Murat Acikalin, Cemal Haci, Fazilet Altin, Yalcin Alimaoglu

Abstract

Background

Tinnitus is a common disease in public. It is not only associated with neuronal, muscular, vascular pathologies, but also with related psychological parameters. In this study, we aimed to investigate the relationship between tinnitus, anxiety and depression in patients undergoing tympanoplasty.

Methods

Patients with tinnitus and operated for chronic otitis media were included in our study. Before and after the operation, tinnitus handicap inventory, beck anxiety and depression scales were filled and pre- and postoperative values were compared. In addition, our patients were divided into two groups as tinnitus improve and did not improve and differences between them were investigated.

Results

148 patients were included in our study. Of 148 patients, 60 were male and 88 were female. There was no significant difference between the patients with and without tinnitus when the dermografic features, hearing levels and physical examination findings were compared.

After the operation, the patients who did not improve tinnitus had higher levels of depression and depression than others (<0.001).

Conclusion

As a result of our study, anxiety and depression scales of the patients whose tinnitus did not improve were found to be higher than the patients whose tinnitus improved.

https://ift.tt/2TAsfXa

Submental flap for reconstruction of anterior skull base, orbital, and high facial defects

Publication date: Available online 22 November 2018

Source: American Journal of Otolaryngology

Author(s): Brent A. Chang, S. Ryan Hall, Brittany E. Howard, Gregory S. Neel, Carrlene Donald, Devyani Lal, Thomas H. Nagel, Richard E. Hayden

Abstract

Purpose

Large anterior skull base, orbital, and high facial defects can present a challenging reconstructive problem. Limited data exists in the literature on the use of a submental flap for reconstructing such defects. We aimed to describe the feasibility, success, and advantages of using variations of the submental flap for reconstruction of anterior skull base, orbital, and high facial defects.

Materials & methods

Outcomes measured included flap method, flap survival, flap size, reconstructive site complications, donor site complications, and length of hospital stay.

Results

Nine patients were identified that underwent submental flap reconstruction of anterior skull base, orbital, or high facial soft tissue defects. There were 5 pedicled, 2 hybridized, and 2 free submental flap reconstructions. Flap survival was 100%. One flap required leech therapy for early post-operative venous congestion. Average flap skin paddle size was 63.7 cm². Average length of hospital stay was 7.3 days. No complications from the donor site were reported.

Conclusions

Different variations on the submental flap are viable options for reconstruction of high defects in the head and neck. Such flaps have a number of unique qualities that are suitable for reconstruction of anterior skull base, orbital, and high facial defects.

https://ift.tt/2AfPL2P

Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort

Stefler, D; Malyutina, S; Maximov, V; Orlov, P; Ivanoschuk, D; Nikitin, Y; Gafarov, V; ... Holmes, MV; + view all Stefler, D; Malyutina, S; Maximov, V; Orlov, P; Ivanoschuk, D; Nikitin, Y; Gafarov, V; Ryabikov, A; Voevoda, M; Bobak, M; Holmes, MV; - view fewer (2018) Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort. Scientific Reports , 8 , Article 16627. 10.1038/s41598-018-35122-y . Green open access

https://ift.tt/2qZR3L5

Ab-normal saline in abnormal kidney function: risks and alternatives

Hayes, W; (2018) Ab-normal saline in abnormal kidney function: risks and alternatives. [Review]. Pediatric Nephrology 10.1007/s00467-018-4008-1 . (In press). Green open access

https://ift.tt/2FDiwwp

Peer relationships and friendships: Perspectives from Pupils and Staff at a Secondary Pupil Referral Unit (PRU)

Lee, Jade Fiona Jak Kee; (2018) Peer relationships and friendships: Perspectives from Pupils and Staff at a Secondary Pupil Referral Unit (PRU). Doctoral thesis (D.Ed.Psy), UCL (University College London). Green open access

https://ift.tt/2r0RGnv

Autophagy in neurodegeneration and aging

Miki, Y; Holton, JL; Wakabayashi, K; (2018) Autophagy in neurodegeneration and aging. Aging 10.18632/aging.101652 . (In press). Green open access

https://ift.tt/2FBwlLI

Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling

Richards, T; Modarage, K; Dean, C; McCarthy-Boxer, A; Hilton, H; Esapa, C; Norman, J; ... Goggolidou, P; + view all Richards, T; Modarage, K; Dean, C; McCarthy-Boxer, A; Hilton, H; Esapa, C; Norman, J; Wilson, P; Goggolidou, P; - view fewer (2018) Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 10.1016/j.bbadis.2018.11.003 . (In press). Green open access

https://ift.tt/2qYM1yn

Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity

McCormick, PN; Greenwood, HE; Glaser, M; Maddocks, ODK; Gendron, T; Sander, K; Gowrishankar, G; ... Witney, TH; + view all McCormick, PN; Greenwood, HE; Glaser, M; Maddocks, ODK; Gendron, T; Sander, K; Gowrishankar, G; Hoehne, A; Zhang, T; Shuhendler, AJ; Lewis, DY; Berndt, M; Koglin, N; Lythgoe, MF; Gambhir, SS; Årstad, E; Witney, TH; - view fewer (2018) Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity. Cancer Research 10.1158/0008-5472.CAN-18-2634 . (In press).

https://ift.tt/2FBOg4Y

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

Mitchell, AL; Attwood, TK; Babbitt, PC; Blum, M; Bork, P; Bridge, A; Brown, SD; ... Finn, RD; + view all Mitchell, AL; Attwood, TK; Babbitt, PC; Blum, M; Bork, P; Bridge, A; Brown, SD; Chang, H-Y; El-Gebali, S; Fraser, MI; Gough, J; Haft, DR; Huang, H; Letunic, I; Lopez, R; Luciani, A; Madeira, F; Marchler-Bauer, A; Mi, H; Natale, DA; Necci, M; Nuka, G; Orengo, C; Pandurangan, AP; Paysan-Lafosse, T; Pesseat, S; Potter, SC; Qureshi, MA; Rawlings, ND; Redaschi, N; Richardson, LJ; Rivoire, C; Salazar, GA; Sangrador-Vegas, A; Sigrist, CJA; Sillitoe, I; Sutton, GG; Thanki, N; Thomas, PD; Tosatto, SCE; Yong, S-Y; Finn, RD; - view fewer (2018) InterPro in 2019: improving coverage, classification and access to protein sequence annotations. Nucleic Acids Research 10.1093/nar/gky1100 . Green open access

https://ift.tt/2qZeZ1f

The causal impact of material productivity on microeconomic competitiveness and environmental performance in the European Union

Flachenecker, F; Kornejew, M; (2018) The causal impact of material productivity on microeconomic competitiveness and environmental performance in the European Union. Environmental Economics and Policy Studies 10.1007/s10018-018-0223-z . (In press). Green open access

https://ift.tt/2FyNHZp

Incidence and predictors of left ventricular thrombus by cardiovascular magnetic resonance in acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: a meta-analysis

Bulluck, H; Chan, MHH; Paradies, V; Yellon, RL; Ho, HH; Chan, MY; Chin, CWL; ... Hausenloy, DJ; + view all Bulluck, H; Chan, MHH; Paradies, V; Yellon, RL; Ho, HH; Chan, MY; Chin, CWL; Tan, JW; Hausenloy, DJ; - view fewer (2018) Incidence and predictors of left ventricular thrombus by cardiovascular magnetic resonance in acute ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: a meta-analysis. Journal of Cardiovascular Magnetic Resonance , 20 (1) , Article 72. 10.1186/s12968-018-0494-3 . Green open access

https://ift.tt/2r1WcCu

Global Alliance for Chronic Disease researchers' statement on multimorbidity

Hurst, JR; Dickhaus, J; Maulik, PK; Miranda, JJ; Pastakia, SD; Soriano, JB; Siddharthan, T; ... GACD Multi-Morbidity Working Group, ; + view all Hurst, JR; Dickhaus, J; Maulik, PK; Miranda, JJ; Pastakia, SD; Soriano, JB; Siddharthan, T; Vedanthan, R; GACD Multi-Morbidity Working Group, ; - view fewer (2018) Global Alliance for Chronic Disease researchers' statement on multimorbidity. Lancet Global Health , 6 (12) e1270-e1271. 10.1016/S2214-109X(18)30391-7 . Green open access

https://ift.tt/2FyQcLv

Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience

Graham, D; Sever, N; Magee, C; Waddingham, W; Banks, M; Sweis, R; Al-Yousuf, H; ... Haidry, R; + view all Graham, D; Sever, N; Magee, C; Waddingham, W; Banks, M; Sweis, R; Al-Yousuf, H; Mitchison, M; Alzoubaidi, D; Rodriguez-Justo, M; Lovat, L; Novelli, M; Jansen, M; Haidry, R; - view fewer (2018) Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience. World Journal of Gastroenterology , 24 (41) pp. 4698-4707. 10.3748/wjg.v24.i41.4698 . Green open access

https://ift.tt/2qZ21jN

Revisiting Panda 100, the first archaeological chimpanzee nut-cracking site

Proffitt, T; Haslam, M; Mercader, JF; Boesch, C; Luncz, LV; (2018) Revisiting Panda 100, the first archaeological chimpanzee nut-cracking site. Journal of Human Evolution , 124 pp. 117-139. 10.1016/j.jhevol.2018.04.016 .

https://ift.tt/2FzEpwg

Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae

Pathania, M; Acosta-Gutierrez, S; Bhamidimarri, SP; Basle, A; Winterhalter, M; Ceccarelli, M; van den Berg, B; (2018) Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae. Structure , 26 (5) pp. 708-721. 10.1016/j.str.2018.03.010 .

https://ift.tt/2qZR1CX

Impact of Dementia on Mindful Attention: a Cross-Sectional Comparison of People with Dementia and Those Without

Bousfield, C; Stott, J; (2018) Impact of Dementia on Mindful Attention: a Cross-Sectional Comparison of People with Dementia and Those Without. Mindfulness 10.1007/s12671-018-0972-6 . (In press). Green open access

https://ift.tt/2FDirc5

Validation of a novel mapping system and utility for mapping complex atrial tachycardias

Honarbakhsh, S; Hunter, RJ; Dhillon, G; Ullah, W; Keating, E; Providencia, R; Chow, A; ... Schilling, RJ; + view all Honarbakhsh, S; Hunter, RJ; Dhillon, G; Ullah, W; Keating, E; Providencia, R; Chow, A; Earley, MJ; Schilling, RJ; - view fewer (2018) Validation of a novel mapping system and utility for mapping complex atrial tachycardias. Journal of Cardiovascular Electrophysiology , 29 (3) , Article 13437. 10.1111/jce.13437 .

https://ift.tt/2qZeWm5

Author Correction: Development and validation of a risk prediction model for work disability: multicohort study

Airaksinen, J; Jokela, M; Virtanen, M; Oksanen, T; Pentti, J; Vahtera, J; Koskenvuo, M; ... Kivimäki, M; + view all Airaksinen, J; Jokela, M; Virtanen, M; Oksanen, T; Pentti, J; Vahtera, J; Koskenvuo, M; Kawachi, I; Batty, GD; Kivimäki, M; - view fewer (2018) Author Correction: Development and validation of a risk prediction model for work disability: multicohort study. Scientific Reports , 8 , Article 17224. 10.1038/s41598-018-35363-x . Green open access

https://ift.tt/2FDiiW5

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Choy, M-K; Javierre, BM; Williams, SG; Baross, SL; Liu, Y; Wingett, SW; Akbarov, A; ... Keavney, BD; + view all Choy, M-K; Javierre, BM; Williams, SG; Baross, SL; Liu, Y; Wingett, SW; Akbarov, A; Wallace, C; Freire-Pritchett, P; Rugg-Gunn, PJ; Spivakov, M; Fraser, P; Keavney, BD; - view fewer (2018) Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Nature Communications , 9 , Article 4792. 10.1038/s41467-018-07399-0 . Green open access

https://ift.tt/2r25ePM

From curriculum design to enactment in technology enhanced mathematics instruction – Mind the gap!

Clark-Wilson, AM; Hoyles, CM; (2019) From curriculum design to enactment in technology enhanced mathematics instruction – Mind the gap! International Journal of Educational Research (In press).

https://ift.tt/2FDie8N

Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation

Gkazi, AS; Margetts, BK; Attenborough, T; Mhaldien, L; Standing, JF; Oakes, T; Heather, JM; ... Adams, SP; + view all Gkazi, AS; Margetts, BK; Attenborough, T; Mhaldien, L; Standing, JF; Oakes, T; Heather, JM; Booth, J; Pasquet, M; Chiesa, R; Veys, P; Klein, N; Chain, B; Callard, R; Adams, SP; - view fewer (2018) Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation. Frontiers in Immunology , 9 , Article 2547. 10.3389/fimmu.2018.02547 . Green open access

https://ift.tt/2qZxzWM

Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy

Ochoa, JP; Sabater-Molina, M; García-Pinilla, JM; Mogensen, J; Restrepo-Córdoba, A; Palomino-Doza, J; Villacorta, E; ... Monserrat, L; + view all Ochoa, JP; Sabater-Molina, M; García-Pinilla, JM; Mogensen, J; Restrepo-Córdoba, A; Palomino-Doza, J; Villacorta, E; Martinez-Moreno, M; Ramos-Maqueda, J; Zorio, E; Peña-Peña, ML; García-Granja, PE; Rodríguez-Palomares, JF; Cárdenas-Reyes, IJ; de la Torre-Carpente, MM; Bautista-Pavés, A; Akhtar, MM; Cicerchia, MN; Bilbao-Quesada, R; Mogollón-Jimenez, MV; Salazar-Mendiguchía, J; Mesa Latorre, JM; Arnaez, B; Olavarri-Miguel, I; Fuentes-Cañamero, ME; Lamounier, A; Pérez Ruiz, JM; Climent-Payá, V; Pérez-Sanchez, I; Trujillo-Quintero, JP; Lopes, LR; Repáraz-Andrade, A; Marín-Iglesias, R; Rodriguez-Vilela, A; Sandín-Fuentes, M; Garrote, JA; Cortel-Fuster, A; Lopez-Garrido, M; Fontalba-Romero, A; Ripoll-Vera, T; Llano-Rivas, I; Fernandez-Fernandez, X; Isidoro-García, M; Garcia-Giustiniani, D; Barriales-Villa, R; Ortiz-Genga, M; García-Pavía, P; Elliott, PM; Gimeno, JR; Monserrat, L; - view fewer (2018) Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology , 72 (20) pp. 2457-2467. 10.1016/j.jacc.2018.10.001 . Green open access

https://ift.tt/2FAeGUD

The efficacy of neutron radiation therapy in treating salivary gland malignancies

Publication date: January 2019

Source: Oral Oncology, Volume 88

Author(s): Mari-Alina Timoshchuk, Preston Dekker, Daniel S. Hippe, Upendra Parvathaneni, Jay J. Liao, George E. Laramore, Jasjit K. Dillon

Abstract

Objectives

Radiation therapy is commonly used to treat head and neck malignancies. While there is abundant research regarding photon radiation therapy, literature on neutron radiotherapy (NRT) and oral complications is limited. This study aims to determine: (1) the 6-year and 10-year locoregional control and survival rates, (2) factors associated with locoregional control and survival and (3) the frequency of oral complications in patients undergoing NRT for salivary gland malignancies.

Materials and methods

This is a retrospective cohort study. The sample was composed of patients with salivary gland malignancies treated with NRT between 1997 and 2010. Data were extracted from patient charts, telephone surveys, and social security records. Multivariate competing risk and Cox regression models were used to assess predictors of locoregional control and survival.

Results

The sample was composed of 545 subjects with a mean age of 54.2 years (±16). The predominant tumor and location were adenoid cystic carcinoma (47%) and the parotid (56%). Multivariate analysis indicated that positive surgical margins, biopsied/inoperable malignancies, neck involvement, and lymphovascular invasion were prognostic risk factors associated with decreased survival. The 6- and 10-year locoregional control rates were 84% and 79%. The 6- and 10-year survival rates were 72% and 62%. Osteoradionecrosis developed in 3.4% of subjects.

Conclusions

The 6- and 10-year locoregional control and survival rates compare favorably to rates reported for conventional photon radiation. Osteoradionecrosis rates were comparable to that of photon radiation treatment (2–7%). Given the potential benefits of NRT, healthcare professionals should be educated regarding its indications and oral complications.

https://ift.tt/2Kq6HrV

Unmet supportive care needs in patients treated with total laryngectomy and its associated factors

Abstract

Background

The purpose of this study was to investigate unmet supportive care needs in patients treated with total laryngectomy and its associated factors.

Methods

In this cross‐sectional study, 283 patients who underwent total laryngectomy completed questions on supportive care needs (Supportive Care Needs Survey [SCNS]). Median time since total laryngectomy surgery was 7 years (range 0‐37 years). The prevalence of unmet supportive care needs and its associated factors were investigated using logistic regression analyses.

Results

Unmet supportive care needs were highest for the head and neck cancer‐specific functioning domain (53%), followed by the psychological (39%), physical and daily living (37%), health system, information, and patient support (35%), sexuality (23%), and lifestyle (5%) domains. Seventy‐one percent reported at least one low, moderate, or high unmet need. Female sex, living alone, and having a voice prosthesis were positively associated with unmet needs on 1 domain (P < .05). A worse health‐related quality of life was associated with unmet needs on all domains.

Conclusion

The majority of patients who underwent total laryngectomy report at least one low, moderate, or high unmet supportive care need.

https://ift.tt/2DSWzYa

Fine‐needle aspiration cytology vs core‐needle biopsy for the diagnosis of extracranial head and neck schwannoma

Abstract

Background

We aimed to investigate the feasibility of diagnosing head and neck schwannomas using core‐needle biopsy (CNB), and to compare this technique to fine‐needle aspiration cytology (FNAC).

Methods

We designed a prospective case series in which 52 FNAC and 29 CNB samples from 48 patients with head and neck schwannoma were analyzed. Patient demographics, pathological results, and complications were also evaluated.

Results

Of the 81 total specimens, 24/52 (46.2%) of the FNAC and 0/29 (0.0%) of the CNB samples were unsatisfactory (P < .001). Specific diagnoses of schwannoma, including "suspicious schwannoma" and "consistent with schwannoma," were obtained from 10/52 (19.2%) of the FNAC samples and 28/29 (96.6%) of the CNB samples (P < .001). Major complications such as hematoma or permanent nerve injury did not occur in patients who underwent either method.

Conclusions

CNB can diagnose schwannomas with a higher accuracy than FNAC without increasing the rate of complications.

https://ift.tt/2S8G8u5

18F‐FDG PET/CT for locoregional surveillance following definitive treatment of head and neck cancer: A meta‐analysis of reported studies

Abstract

Purpose

To evaluate the performance of ¹⁸F‐fluorodeoxy‐d‐glucose positron emission tomography‐computed tomography (¹⁸F‐FDG PET/CT) in identifying local failure and regional failure following curative radiotherapy or surgery for head and neck squamous cell carcinoma.

Methods

A comprehensive literature search identified studies published between January 2010 and August 2016. Diagnostic performance of ¹⁸F‐FDG PET/CT was evaluated for local failure/regional failure stratified by treatment‐to‐scan time interval of ≤3 versus >3 months.

Results

Twenty‐four studies (2627 patients) were included. Compared to ≤3 months, ¹⁸F‐FDG PET/CT performed >3 months showed significantly improved sensitivity (87% vs 60%, P = 0.020) and specificity (93% vs 84%, P < 0.001) for local failure. There was no significant difference in sensitivity (79% vs 56%, P = 0.100) or specificity (95% vs 97%, P = 0.35) for regional failure >3 versus ≤3 months.

Conclusions

This meta‐analysis confirms high specificity but modest sensitivity of posttreatment ¹⁸F‐FDG PET/CT for local failure and regional failure. Sensitivity and specificity are significantly improved when ¹⁸F‐FDG PET/CT is performed >3 months for local failure.

https://ift.tt/2DOXY20

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma

Abstract

Background

Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.

Methods

CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.

Results

Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival.

Conclusions

We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.

https://ift.tt/2S1XVTu

Gamma Knife radiosurgery for glomus tumors: Long‐term results in a series of 30 patients

Abstract

Background

Glomus tumors are rare and benign hypervascular tumors. Surgery represented the mainstay of their treatment, even if it has been associated with high morbidity and mortality rates. Recently, the treatment shifted to a multimodal approach and Gamma Knife radiosurgery represents one of the treatment options.

Methods

Authors retrospectively analyzed the clinical and radiological outcome of a series of patients who underwent Gamma Knife radiosurgery for glomus tumors.

Results

Thirty patients underwent Gamma Knife radiosurgery. Mean tumor volume was 7.69 cc (range 0.36‐24.6). Mean tumor margin dose was 16 Gy (range 13‐18). Median follow‐up was of 91 months (mean 90; range 11‐172). Overall clinical control rate was 100%; overall volumetric tumor control rate was 96.6%. Patients' and tumors' characteristics, treatment data, and outcome have been analyzed.

Conclusion

Gamma Knife radiosurgery represents a safe and effective treatment for glomus tumors. Longer follow‐up and larger cohort studies are needed to definitively outline the role of Gamma Knife radiosurgery for glomus tumors.

https://ift.tt/2DRKgM2

Chronic Rhinosinusitis in Elderly Patients is Associated with an Exaggerated Neutrophilic Pro-Inflammatory Response to Pathogenic Bacteria

Publication date: Available online 22 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Justin C. Morse, Ping Li, Kim A. Ely, Meghan H. Shilts, Todd J. Wannemuehler, Li-Ching Huang, Quanhu Sheng, Naweed I. Chowdhury, Rakesh K. Chandra, Suman R. Das, Justin H. Turner

Abstract

Background

Potential effects of aging on chronic rhinosinusitis (CRS) pathophysiology have not been well defined, but may have important ramifications given a rapidly aging U.S. and world population.

Objective

The goal of the current study was to determine whether advanced age is associated with specific inflammatory CRS endotypes or immune signatures.

Methods

Seventeen mucus cytokines and inflammatory mediators were measured in 147 CRS patients. Hierarchical cluster analysis was used to identify and characterize inflammatory CRS endotypes as well as determine whether age was associated with specific immune signatures.

Results

A CRS endotype with a pro-inflammatory, neutrophilic immune signature was enriched with older patients. In the overall cohort, patients 60 years and older had elevated mucus levels of IL-1β, IL-6, IL-8, and TNF-α when compared to their younger counterparts. Increases in pro-inflammatory cytokines were associated with both tissue neutrophilia and symptomatic bacterial infection/colonization in aged patients.

Conclusions

Aged CRS patients have a unique inflammatory signature that corresponds to a neutrophilic pro-inflammatory response. Neutrophil-driven inflammation in aged CRS patients may be less likely to respond to corticosteroids and may be closely linked with chronic microbial infection or colonization.

Graphical abstract

https://ift.tt/2DEPHgr

Editorial board

Publication date: November 2018

Source: Annales de Dermatologie et de Vénéréologie, Volume 145, Issue 11

Author(s):

https://ift.tt/2S4x7Cj

Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils

Publication date: Available online 22 November 2018

Source: Clinical Immunology

Author(s): Emma Weeding, Patrick Coit, Srilakshmi Yalavarthi, Mariana J. Kaplan, Jason S. Knight, Amr H. Sawalha

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thromboembolic events and pregnancy loss. We sought to characterize the DNA methylation profile of primary APS in comparison to healthy controls and individuals with SLE. In primary APS neutrophils compared to controls, 17 hypomethylated and 25 hypermethylated CpG sites were identified. Notable hypomethylated genes included ETS1, a genetic risk locus for SLE, and PTPN2, a genetic risk locus for other autoimmune diseases. Gene ontology analysis of hypomethylated genes revealed enrichment of genes involved in pregnancy. None of the differentially methylated sites in primary APS were differentially methylated in SLE neutrophils, and there was no demethylation of interferon signature genes in primary APS as is seen in SLE. Hypomethylation within a single probe in the IFI44L promoter (cg06872964) was able to distinguish SLE from primary APS with a sensitivity of 93.3% and specificity of 80.0% at a methylation fraction of 0.329.

https://ift.tt/2BpOFDt

Clinical Immunology: A Special Issue on Epigenetics

Publication date: Available online 22 November 2018

Source: Clinical Immunology

Author(s): Amr H. Sawalha

https://ift.tt/2KtHEo8

Acknowledgment to reviewers

https://ift.tt/2AiEnD8

Towards a theory of carrying capacity, evidence from long-term longitudinal case studies of occupant satisfaction in non-domestic buildings

Bunn, Roderic; (2018) Towards a theory of carrying capacity, evidence from long-term longitudinal case studies of occupant satisfaction in non-domestic buildings. Doctoral thesis (Eng.D), UCL (University College London).

https://ift.tt/2DPcYgB

Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial

Hopewell, S; Boutron, I; Altman, DG; Barbour, G; Moher, D; Montori, V; Schriger, D; ... Ravaud, P; + view all Hopewell, S; Boutron, I; Altman, DG; Barbour, G; Moher, D; Montori, V; Schriger, D; Cook, J; Gerry, S; Omar, O; Dutton, P; Roberts, C; Frangou, E; Clifton, L; Chiocchia, V; Rombach, I; Wartolowska, K; Ravaud, P; - view fewer (2016) Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial. BMC Medicine , 14 , Article 199. 10.1186/s12916-016-0736-x . Green open access

https://ift.tt/2S5y0ug

Erratum to: Measurement of the W-boson mass in pp collisions at s√=7TeV with the ATLAS detector (vol 78, 110, 2018)

Aaboudd, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Abidi, SH; ... Zwalinski, L; + view all Aaboudd, M; Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Abeloos, B; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adams, DL; Adelman, J; Adersberger, M; Adye, T; Affolder, AA; Agatonovic-Jovin, T; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahlen, SP; Ahmadov, F; Aielli, G; Akatsuka, S; Akerstedt, H; Akesson, TPA; Akimov, AV; Alberghi, GL; Albert, J; Alconada Verzini, MJ; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Ali, B; Aliev, M; Alimonti, G; Alison, J; Alkire, SP; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, M; Alvarez Gonzalez, B; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amorim, A; Amoroso, S; Amundsen, G; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Angerami, A; Anghinolfi, F; Anisenkov, AV; Anjos, N; Annovi, A; Antel, C; Antonelli, M; Antonov, A; Antrim, DJ; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Ferraz, VA; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, AJ; Armitage, LJ; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Baines, JT; Bajic, M; Baker, OK; Baldin, EM; Balek, P; Balestri, T; Balli, F; Balunas, WK; Banas, E; Banerjee, S; Bannoura, AAE; Barak, L; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barklow, T; Barlow, N; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Navarro, LB; Barreiro, F; da Costa, JBG; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, P; Beck, HP; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, AJ; Beddall, A; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertram, IA; Bertsche, C; Bertsche, D; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Betancourt, C; Bethani, A; Bethke, S; Bevan, AJ; Bianchi, RM; Biebel, O; Biedermann, D; Bianco, M; Bielski, R; Biesuz, NV; Biglietti, M; De Mendizabal, JB; Billoud, TRV; Bilokon, H; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Bittrich, C; Bjergaard, DM; Black, CW; Black, JE; Black, KM; Blackburn, D; Blair, RE; Blanchard, J-B; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blum, W; Blumenschein, U; Blunier, S; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Bock, C; Boehler, M; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Sola, JDB; Boudreau, J; Bouffard, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Briglin, DL; Bristow, TM; Britton, D; Britzger, D; Brochu, FM; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brosamer, J; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, F; Bugge, MK; Bulekov, O; Bullock, D; Burckhart, H; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Busato, E; Buescher, D; Buescher, V; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabrera Urban, S; Caforio, D; Cairo, VM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Calvente Lopez, S; Calvet, D; Calvet, S; Calvet, TP; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; Canale, V; Bret, MC; Cantero, J; Cao, T; Garrido, MDMC; Caprini, I; Caprini, M; Capua, M; Carbone, RM; Cardarelli, R; Cardillo, F; Carli, I; Carli, T; Carlino, G; Carlson, BT; Carminati, L; Carney, RMD; Caron, S; Carquin, E; Carrillo-Montoya, GD; Carvalho, J; Casadei, D; Casado, MP; Casolino, M; Casper, DW; Castelijn, R; Castelli, A; Castillo Gimenez, V; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Cerda Alberich, L; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chatterjee, A; Chau, CC; Barajas, CAC; Che, S; Cheatham, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, H; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, HC; Cheng, HJ; Cheng, Y; Cheplakov, A; Cheremushkina, E; Cherkaoui El Moursli, R; Chernyatin, V; Cheu, E; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, BKB; Christodoulou, V; Chromek-Burckhart, D; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Ciftci, AK; Cinca, D; Cindro, V; Cioara, IA; Ciocca, C; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Ciubancan, M; Clark, A; Clark, BL; Clark, MR; Clark, PJ; Clarke, RN; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Colombo, T; Conde Muino, P; Coniavitis, E; Connell, SH; Connelly, IA; Consorti, V; Constantinescu, S; Conti, G; Conventi, F; Cooke, M; Cooper, BD; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Cornelissen, T; Corradi, M; Corriveau, F; Cortes-Gonzalez, A; Cortiana, G; Costa, G; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cribbs, WA; Ortuzar, MC; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cummings, J; Curatolo, M; Cuth, J; Czirr, H; Czodrowski, P; D'amen, G; D'Auria, S; D'Onofrio, M; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dai, T; Dale, O; Dallaire, F; Dallapiccola, C; Dam, M; Dandoy, JR; Dang, NP; Daniells, AC; Dann, NS; Danninger, M; Hoffmann, MD; Dao, V; Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davies, M; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Dearnaley, WJ; Debbe, R; Debenedetti, C; Dedovich, DV; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Del Prete, T; Delgove, D; Deliot, F; Delitzsch, CM; Dell'Acqua, A; Dell'Asta, L; Dell'Orso, M; Della Pietra, M; della Volpe, D; Delmastro, M; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Demilly, A; Denisov, SP; Denysiuk, D; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Diaz, MA; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dita, P; Dita, S; Dittus, F; Djama, F; Djobava, T; Djuvsland, JI; do Vale, MAB; Dobos, D; Dobre, M; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donati, S; Dondero, P; Donini, J; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dris, M; Du, Y; Duarte-Campderros, J; Duchovni, E; Duckeck, G; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duhrssen, M; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Yildiz, HD; Dueren, M; Durglishvili, A; Duschinger, D; Dutta, B; Dyndal, M; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; Ellajosyula, V; Ellert, M; Elles, S; Ellinghaus, F; Elliot, AA; Ellis, N; Elmsheuser, J; Elsing, M; Emeliyanov, D; Enari, Y; Endner, OC; Ennis, JS; Erdmann, J; Ereditato, A; Ernis, G; Ernst, M; Errede, S; Ertel, E; Escalier, M; Esch, H; Escobar, C; Esposito, B; Etienvre, AI; Etzion, E; Evans, H; Ezhilov, A; Fabbri, F; Fabbri, L; Facini, G; Fakhrutdinov, RM; Falciano, S; Falla, RJ; Faltova, J; Fang, Y; Fanti, M; Farbin, A; Farilla, A; Farina, C; Farina, EM; Farooque, T; Farrell, S; Farrington, SM; Farthouat, P; Fassi, F; Fassnacht, P; Fassouliotis, D; Giannelli, MF; Favareto, A; Fawcett, WJ; Fayard, L; Fedin, OL; Fedorko, W; Feigl, S; Feligioni, L; Feng, C; Feng, EJ; Feng, H; Fenyuk, AB; Feremenga, L; Fernandez Martinez, P; Perez, SF; Ferrando, J; Ferrari, A; Ferrari, P; Ferrari, R; de Lima, DEF; Ferrer, A; Ferrere, D; Ferretti, C; Fiedler, F; Filipcic, A; Filipuzzi, M; Filthaut, F; Fincke-Keeler, M; Finelli, KD; Fiolhais, MCN; Fiorini, L; Fischer, A; Fischer, C; Fischer, J; Fisher, WC; Flaschel, N; Fleck, I; Fleischmann, P; Fletcher, RRM; Flick, T; Flierl, BM; Castillo, LRF; Flowerdew, MJ; Forcolin, GT; Formica, A; Forti, A; Foster, AG; Fournier, D; Fox, H; Fracchia, S; Francavilla, P; Franchini, M; Francis, D; Franconi, L; Franklin, M; Frate, M; Fraternali, M; Freeborn, D; Fressard-Batraneanu, SM; Freund, B; Froidevaux, D; Frost, JA; Fukunaga, C; Torregrosa, EF; Fusayasu, T; Fuster, J; Gabaldon, C; Gabizon, O; Gabrielli, A; Gabrielli, A; Gach, GP; Gadatsch, S; Gadomski, S; Gagliardi, G; Gagnon, LG; Gagnon, P; Galea, C; Galhardo, B; Gallas, EJ; Gallop, BJ; Gallus, P; Galster, G; Gan, KK; Ganguly, S; Gao, J; Gao, Y; Gao, YS; Walls, FMG; Garcia, C; Garcia Navarro, JE; Garcia-Sciveres, M; Gardner, RW; Garelli, N; Garonne, V; Bravo, AG; Gasnikova, K; Gatti, C; Gaudiello, A; Gaudio, G; Gavrilenko, IL; Gay, C; Gaycken, G; Gazis, EN; Gee, CNP; Geisen, M; Geisler, MP; Gellerstedt, K; Gemme, C; Genest, MH; Geng, C; Gentile, S; Gentsos, C; George, S; Gerbaudo, D; Gershon, A; Ghasemi, S; Ghneimat, M; Giacobbe, B; Giagu, S; Giannetti, P; Gibson, SM; Gignac, M; Gilchriese, M; Gillberg, D; Gilles, G; Gingrich, DM; 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Hejbal, J; Helary, L; Held, A; Hellman, S; Helsens, C; Henderson, J; Henderson, RCW; Heng, Y; Henkelmann, S; Correia, AMH; Henrot-Versille, S; Herbert, GH; Herde, H; Herget, V; Jimenez, YH; Herten, G; Hertenberger, R; Hervas, L; Herwig, TC; Hesketh, GG; Hessey, NP; Hetherly, JW; Higashino, S; Higon-Rodriguez, E; Hill, E; Hill, JC; Hiller, KH; Hillier, SJ; Hinchliffe, I; Hirose, M; Hirschbuehl, D; Hiti, B; Hladik, O; Hoad, X; Hobbs, J; Hod, N; Hodgkinson, MC; Hodgson, P; Hoecker, A; Hoeferkamp, MR; Hoenig, F; Hohn, D; Holmes, TR; Homann, M; Honda, S; Honda, T; Hong, TM; Hooberman, BH; Hopkins, WH; Horii, Y; Horton, AJ; Hostachy, J-Y; Hou, S; Hoummada, A; Howarth, J; Hoya, J; Hrabovsky, M; Hristova, I; Hrivnac, J; Hryn'ova, T; Hrynevich, A; Hsu, PJ; Hsu, S-C; Hu, Q; Hu, S; Huang, Y; Hubacek, Z; Hubaut, F; Huegging, F; Huffman, TB; Hughes, EW; Hughes, G; Huhtinen, M; Huo, P; Huseynov, N; Huston, J; Huth, J; Iacobucci, G; Iakovidis, G; Ibragimov, I; Iconomidou-Fayard, L; Iengo, P; Igonkina, O; Iizawa, T; Ikegami, Y; Ikeno, M; Ilchenko, Y; Iliadis, D; Ilic, N; Introzzi, G; Ioannou, P; Iodice, M; Iordanidou, K; Ippolito, V; Ishijima, N; Ishino, M; Ishitsuka, M; Issever, C; Istin, S; Ito, F; Ponce, JMI; Iuppa, R; Iwasaki, H; Izen, JM; Izzo, V; Jabbar, S; Jackson, P; Jain, V; Jakobi, KB; Jakobs, K; Jakobsen, S; Jakoubek, T; Jamin, DO; Jana, DK; Jansky, R; Janssen, J; Janus, M; Janus, PA; Jarlskog, G; Javadov, N; Javurek, T; Javurkova, M; Jeanneau, F; Jeanty, L; Jejelava, J; Jelinskas, A; Jenni, P; Jeske, C; Jezequel, S; Ji, H; Jia, J; Jiang, H; Jiang, Y; Jiang, Z; Jiggins, S; Jimenez Pena, J; Jin, S; Jinaru, A; Jinnouchi, O; Jivan, H; Johansson, P; Johns, KA; Johnson, CA; Johnson, WJ; Jon-And, K; Jones, RWL; Jones, S; Jones, TJ; Jongmanns, J; Jorge, PM; Jovicevic, J; Ju, X; Rozas, AJ; Kohler, MK; Kaczmarska, A; Kado, M; Kagan, H; Kagan, M; Kahn, SJ; Kaji, T; Kajomovitz, E; Kalderon, CW; Kaluza, A; Kama, S; Kamenshchikov, A; Kanaya, N; Kaneti, S; Kanjir, L; Kantserov, VA; Kanzaki, J; 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https://ift.tt/2DS60Hn

Student involvement in quality assurance in HE in FE: perceptions of students, teachers and managers

Scott, Elizabeth A.; (2018) Student involvement in quality assurance in HE in FE: perceptions of students, teachers and managers. Doctoral thesis (Ed.D), UCL (University College London). Green open access

https://ift.tt/2S7Mlqe

Neuropeptidergic Systems in Pluteus Larvae of the Sea Urchin Strongylocentrotus purpuratus: Neurochemical Complexity in a "Simple" Nervous System

Wood, NJ; Mattiello, T; Rowe, ML; Ward, L; Perillo, M; Arnone, MI; Elphick, MR; Wood, NJ; Mattiello, T; Rowe, ML; Ward, L; Perillo, M; Arnone, MI; Elphick, MR; Oliveri, P; - view fewer (2018) Neuropeptidergic Systems in Pluteus Larvae of the Sea Urchin Strongylocentrotus purpuratus: Neurochemical Complexity in a "Simple" Nervous System. Frontiers in Endocrinology , 9 , Article 628. 10.3389/fendo.2018.00628 . Green open access

https://ift.tt/2DUmsHt

Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis

Shah, A; Gray, K; Figg, N; Finigan, A; Starks, L; Bennett, M; (2018) Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis. Circulation , 138 (14) pp. 1446-1462. 10.1161/CIRCULATIONAHA.117.033249 . Green open access

https://ift.tt/2S4zZ1Z

School leadership and the school inspection regime: an examination of policy enactment in a coastal area of deprivation

Colman, Alyson; (2018) School leadership and the school inspection regime: an examination of policy enactment in a coastal area of deprivation. Doctoral thesis (Ed.D), UCL (University College London). Green open access

https://ift.tt/2DS8MMT

Primary school leaders creating conditions for teacher learning associated with change: developing an understanding with reference to transformative learning theory

Brett, Ashley Marcel; (2018) Primary school leaders creating conditions for teacher learning associated with change: developing an understanding with reference to transformative learning theory. Doctoral thesis (Ed.D), UCL (University College London). Green open access

https://ift.tt/2S4zSU7

Exploring the rural landscape of the Neo-Assyrian Empire: settlement increase in the Iron Age Near East

Yahambaram, Parthiban; (2018) Exploring the rural landscape of the Neo-Assyrian Empire: settlement increase in the Iron Age Near East. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2DSauOs

Why we love bees and hate wasps

Sumner, S; Law, G; Cini, A; (2018) Why we love bees and hate wasps. Ecological Entomology , 43 pp. 836-845. 10.1111/een.12676 . Green open access

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Morpholino-Mediated Exon Inclusion for SMA

Zhou, H; Muntoni, F; (2018) Morpholino-Mediated Exon Inclusion for SMA. Exon Skipping and Inclusion Therapies , 1828 pp. 467-477. 10.1007/978-1-4939-8651-4_29 .

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Child maltreatment in Zhejiang Province of China: role of parental aggressive tendency and history of maltreatment in childhood

Ni, Y; Zhou, X; Li, LM; Hesketh, T; (2018) Child maltreatment in Zhejiang Province of China: role of parental aggressive tendency and history of maltreatment in childhood. Child Abuse Review , 27 (5) pp. 389-403. 10.1002/car.2520 .

https://ift.tt/2S4zJQz

The feasibility of the dual-task paradigm as a framework for a clinical test of listening effort in cochlear implant users

Willis, Helen; (2018) The feasibility of the dual-task paradigm as a framework for a clinical test of listening effort in cochlear implant users. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2DROkM6

Repeat multiview panchromatic super-resolution restoration using the UCL MAGiGAN system

Tao, Y; Muller, JP; (2018) Repeat multiview panchromatic super-resolution restoration using the UCL MAGiGAN system. In: Bruzzone, L and Bovolo, F, (eds.) Image and Signal Processing for Remote Sensing XXIV. SPIE: Berlin, Germany. Green open access

https://ift.tt/2S8BGeR

Performance of global 3D model retrievals of the Martian surface using the UCL CASP-GO system on CTX stereo images on Linux clusters and Microsoft Azure cloud computing platforms

Tao, Y; Muller, JP; (2018) Performance of global 3D model retrievals of the Martian surface using the UCL CASP-GO system on CTX stereo images on Linux clusters and Microsoft Azure cloud computing platforms. In: Huang, B and López, S and Wu, Z, (eds.) High-Performance Computing in Geoscience and Remote Sensing VIII. SPIE: Berlin, Germany. Green open access

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The Taxonomic Status of the Middle Pleistocene Hominins: A 3D Geometric Morphometric Investigation of Variation in the Supraorbital Region

White, Suzanna; (2018) The Taxonomic Status of the Middle Pleistocene Hominins: A 3D Geometric Morphometric Investigation of Variation in the Supraorbital Region. Doctoral thesis (Ph.D), UCL (University College London).

https://ift.tt/2S4zxRl

The Enactment of England's National Curriculum for English in a British International Primary School in Japan

Watanabe, Tetsuko; (2018) The Enactment of England's National Curriculum for English in a British International Primary School in Japan. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2DSQB9I

Scalable separation methods for the isolation of monosaccharides in a biorefinery context

Ward, David; (2018) Scalable separation methods for the isolation of monosaccharides in a biorefinery context. Doctoral thesis (Ph.D), UCL (University College London). Green open access

https://ift.tt/2S9QYQD

Receptive field properties of koniocellular on/off neurons in the lateral geniculate nucleus of marmoset monkeys

Eiber, CD; Rahman, AS; Pietersen, ANJ; Zeater, N; Dreher, B; Solomon, SG; Martin, PR; (2018) Receptive field properties of koniocellular on/off neurons in the lateral geniculate nucleus of marmoset monkeys. Journal of Neuroscience 10.1523/JNEUROSCI.1679-18.2018 . (In press).

https://ift.tt/2DUmlvx

Putative magnetic quantum criticality in (Sr1−xLax)3Ir2O7

Vale, JG; Hunter, EC; (2018) Putative magnetic quantum criticality in (Sr1−xLax)3Ir2O7. Physical Review B , 98 (10) , Article 100406 (R). 10.1103/PhysRevB.98.100406 . Green open access

https://ift.tt/2S1OyTO

Antinuclear antibody and rheumatoid factor positivity in temporomandibular disorders

Abstract

Background

To investigate the differences in clinical characteristics and long-term treatment outcomes according to antinuclear antibody(ANA) and rheumatoid factor(RF) positivity and the correlation between pain-related and hematological indices in temporomandibular disorders(TMD) patients.

Methods

Clinical examinations were done following the Research Diagnostic Criteria for TMD in 257 patients. Comprehensive screening along with psychological and hematological evaluations (ANA, RF, complete blood cell count, C-reactive protein[CRP] and erythrocyte sedimentation rate[ESR]) were conducted. Clinical characteristics and treatment outcomes were statistically compared between ANA/RF positive and negative groups.

Results

Thirty-nine patients showed ANA/RF positivity. Male patients had smaller comfortable mouth opening(CMO)(p = 0.033) and maximum mouth opening(MMO)(p = 0.016) ranges with more painful neck muscles on palpation when RF/ANA positive. Pain duration, intensity, disability days and psychological distress levels were also higher in RF/ANA positive male patients. Significant correlation was shown in ESR with pain duration(p < 0.05) and numeric rating scale(NRS) before treatment(p < 0.05), CRP with NRS before treatment(p < 0.01), and red blood cell (RBC) with pain intensity(p < 0.05), NRS before treatment(p < 0.01), CMO(p < 0.01), pain on palpation of cervical muscles(p < 0.01), CMO(p < 0.05), and MMO(p < 0.05) 6 months after treatment.

Conclusions

These results may point towards a nonspecific autoimmune disposition in a subgroup of TMD patients. RF and ANA could be considered as a screening test for the detection of autoimmune phenomena in TMD.

https://ift.tt/2OTWbd3