The importance of dermoscopy for the diagnosis of acquired bilateral telangiectatic macules: the angioid streak pattern reveals underlying chronic liver disease

Abstract

Background

Acquired bilateral telangiectatic macules (ABTM) are a newly recognized disease entity, which manifest as multiple telangiectatic pigmented macules confined mostly to the upper arms.

Objectives

To evaluate clinical and dermoscopic features in a group of 50 patients with ABTM and to determine the diagnostic usefulness of dermoscopy in ABTM

Methods

Patients were selected from two tertiary teaching hospitals in Korea (Pusan National University Hospitals [Busan and Yangsan]). Fifty patients (41 males and 9 females; mean age 48.1 years; range 26-78 years) with ABTM were included in the study. The dermoscopic findings were graded using a 4-point scale: none (0), mild (1), moderate (2), and severe (3). In addition, the results of 23 patients with and 27 patients without chronic liver disease (CLD) were compared to determine whether the presence of CLD affect dermoscopic findings.

Results

Three distinct dermoscopic patterns were observed; brown pigmentations, telangiectasia (linear-irregular vessels) and an angioid streak pattern. Brown pigmentation in the group without CLD had higher severity score than those in CLD group (mean score: 2.00 vs 1.48, P =0.033). However, mean telangiectasia severity score was higher in the CLD group (2.14 vs 1.39, P < 0.001). The angioid streak pattern was more severe and more common in patients with CLD than in those without (1.37 vs 0.35 (P < 0.001) and 63.0% vs. 26.1%, respectively).

Conclusion

Detailed observations with dermoscopy can provide first clues of the presence of ABTM and underlying chronic liver disease.

This article is protected by copyright. All rights reserved.

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Disfiguring facial mycoses- a diagnostic and therapeutic challenge

Some fungal infections may lead to devastating destruction of face, sometimes followed by fatal consequences. Conidiobolus coronatus is a rare, but serious emerging fungal pathogen of humans, causing Conidiobolomycosis, commonly infecting nasal mucosa and with potential to extend to involve vital structures such as brain and eyes. Treatment of this infection is extremely difficult and can cause significant disfiguring sequale, unless aggressively treated. We illustrate an interesting case, encountered within a short space of time affected by such infections and emphasize the need for thorough evaluation, investigation and aggressive initial treatment to achieve a good clinical response.

This article is protected by copyright. All rights reserved.

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Prevalence of papular urticaria caused by flea bites and associated factors in children 1–6 years of age in Bogotá, D.C.

Papular urticaria is a chronic inflammatory disease caused by exposure to arthropod bites. The disease has been reported in children attending medical centers, but the causes as the risk factors associated wit...

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A shared decision-making tool for obstructive sleep apnea without tonsillar hypertrophy: A randomized controlled trial

Objectives/Hypothesis

Shared decision-making is a process whereby patients and clinicians jointly establish a treatment plan integrating clinical evidence and patient values and preferences. Although this approach has been successfully employed in numerous medical disciplines, often using shared decision-making tools, otolaryngologic research assessing its use is scant. Our primary objective was therefore to determine if the tools we developed reduced decisional conflict for children with obstructive sleep apnea without tonsillar hypertrophy.

Study Design

Prospective, single-blind, randomized controlled trial.

Methods

We enrolled consecutive patients meeting inclusion criteria who were referred to our multidisciplinary upper airway center. Study patients used a shared decision-making tool whereas controls did not. Measures of decisional conflict (SURE [Sure of myself, Understanding information, Risk benefit ratio, Encouragement], CollaboRATE, and the Decisional Conflict Scale [DCS]) were obtained pre- and postvisit.

Results

We assessed 50 families (study group = 24, controls = 26). The mean age was 8.8 ± 6.6 years, 44% were female, 86% were white, and the mean obstructive apnea-hypopnea index was 12.7 ± 15.6 events/hour. The previsit mean DCS score was similar for controls (42.7) and study patients (40.8) (P = .38). The postvisit mean DCS score for controls was 13.3 and for study patients 6.1 (P = .034). Improvement in this score was greater in the study group (P = .03). At previsit evaluation, 63% of controls and 58% of study patients were unsure about their options. Postvisit, this improved to 4.1% and 0%, respectively.

Conclusions

Families counseled regarding treatment options using shared decision-making tools had significantly less decisional conflict than those who did not use these tools. These positive outcomes suggest that clinicians should consider integrating this approach into clinical practice.

Level of Evidence

1b Laryngoscope, 2017

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Total septal perforation repair with a pericranial flap: Radio-anatomical and clinical findings

Objectives/Hypothesis

Endonasal surgeries are the primary cause of septal perforation (SP). However, trauma, inflammation, infections, neoplasms, or abuse of inhaled drugs can also cause SP. Septal repair is indicated in patients who experience nasal obstruction, crusting, intermittent epistaxis, purulent discharge, or nasal whistling and in those who fail conservative treatment. Multiple approaches have been suggested to repair the SP; however, none has been universally adopted. This study explores the feasibility of repairing a total SP using the pericranial flap (PCF).

Study Design

Anatomical cadaver and radiological study plus case study.

Methods

Total nasal septectomy and endoscopic reconstruction with a PCF was performed in 12 injected cadaveric specimens. Maximum length and area of the nasal septum and the PCF were measured in 75 computed tomography scans. Based on the anatomical study and the radiological measurements of the cadavers, one patient underwent total nasal septum repair.

Results

Anatomic measurements showed that the nasal septum has a mean length of 5.8 ± 0.7 cm, whereas the PCF was on average 18.4 ± 1.3 cm long (mean surface area 121.6 ± 17.7 cm²). Radiological measurements revealed that the PCF should provide a surface area of 40.9 ± 4.2 cm² to account for the total septal area and an additional 30% to account range for potential scar retraction. For total septum repair, the distal edge of the PCF had to be placed 0.8 ± 2.0 cm (3.4 ± 8.7°) from the adopted reference point (vertical projection of the external ear canal). Total septal reconstruction was performed successfully in one patient without complications.

Conclusions

Radio-anatomical data and a case study demonstrate that a PCF allows complete endoscopic repair of the nasal septum.

Level of Evidence

NA Laryngoscope, 2017

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Three-dimensional endoscopy for endoscopic salvage nasopharyngectomy: Preliminary report of experience

Background

Prospective, observational study to assess the efficacy of salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma (NPC) via the endoscopic endonasal approach using a three-dimensional (3D) high-definition endoscopic system.

Methods

Between 2016 and 2017, 30 patients with recurrent NPC were recruited. Patient demographics, tumor characteristics, and perioperative data were recorded. Instrument ergonomics and perceived advantages were assessed by the operating, assisting, and observing surgeons.

Results

The majority (70%) of patients received radiotherapy alone as the initial treatment for NPC, and tumor recurred after a mean interval of 16.8 months. The tumor (T) classifications of the recurrent (R) tumors were: RT1: 46.7%; RT2: 33.3%; and RT3: 20.0%. The mean operative time was 293.3 minutes, and no conversion to open approach was necessary. Internal carotid artery dissection was required in nine patients, and the resection and repair of dura was required in six patients. The most common method of reconstruction was free vastus lateralis flap (46.7%). Microscopically clear resection margins were achieved in 73.3% of patients. The mean hospital stay was 6.8 days. There was no hospital mortality. One patient developed minor secondary hemorrhage, whereas the other developed transient contralateral vocal cord paralysis. On quantitative assessment, surgeons noticed a significant advantage of the 3D system with regard to depth and size perception, anatomy identification, and hand–eye coordination, whereas there was no significant difference in terms of strain sensation and dizziness.

Conclusion

The 3D high-definition endoscopic system improves the precision of endoscopic nasopharyngectomy, particularly when dissection of the internal carotid artery and dura is required.

Level of Evidence

4. Laryngoscope, 2017

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Telemedicine in laryngology: Remote evaluation of voice disorders-setup and initial experience

http://ift.tt/2AiDVDp

The contribution of cochlear implants to postural stability

Objectives

To determine whether spatial auditory cues provided by cochlear implants can improve postural balance in adults with severe deafness.

Methods

In the presence of spatial white noise, 13 adult cochlear implantees wore head and lumbar-mounted inertial sensors while standing in the dark for 30 seconds in two auditory conditions: hearing assistive devices on and off.

Results

Stability was improved with implants on (aided condition) compared to off (unaided condition) with respect to differences in mean head velocity (Cohen's d = 0.912, P = 0.006) as well as to root mean square (RMS) acceleration (Cohen's d = 0.456, P = 0.048). This was particularly evident in measures of anteroposterior accelerations (mean difference = 0.034 m/s²; Cohen's d = 0.612; P = 0.011).

Conclusion

The decrease in RMS head acceleration and velocity while wearing cochlear implants suggests that they could be recognized as balance implants in addition to auditory implants. The clinical importance of this finding in various patient populations remains to be determined.

Level of Evidence

4. Laryngoscope, 2017

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When should therapeutic anticoagulation be restarted following major head and neck surgery?

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In reference to intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks

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Proton density–weighted laryngeal magnetic resonance imaging in systemically dehydrated rats

Objectives/Hypothesis

Dehydrated vocal folds are inefficient sound generators. Although systemic dehydration of the body is believed to induce vocal fold dehydration, this causative relationship has not been demonstrated in vivo. Here we investigate the feasibility of using in vivo proton density (PD)–weighted magnetic resonance imaging (MRI) to demonstrate hydration changes in vocal fold tissue following systemic dehydration in rats.

Study Design

Animal study.

Methods

Sprague-Dawley rats (n = 10) were imaged at baseline and following a 10% reduction in body weight secondary to withholding water. In vivo, high-field (7 T), PD-weighted MRI was used to successfully resolve vocal fold and salivary gland tissue structures.

Results

Normalized signal intensities within the vocal fold decreased postdehydration by an average of 11.38% ± 3.95% (mean ± standard error of the mean [SEM], P = .0098) as compared to predehydration levels. The salivary glands experienced a similar decrease in normalized signal intensity by an average of 10.74% ± 4.14% (mean ± SEM, P = .0195) following dehydration. The correlation coefficient (percent change from dehydration) between vocal folds and salivary glands was 0.7145 (P = .0202).

Conclusions

Ten percent systemic dehydration induced vocal fold dehydration as assessed by PD-weighted MRI. Changes in the hydration state of vocal fold tissue were highly correlated with that of the salivary glands in dehydrated rats in vivo. These preliminary findings demonstrate the feasibility of using PD-weighted MRI to quantify hydration states of the vocal folds and lay the foundation for further studies that explore more routine and realistic magnitudes of systemic dehydration and rehydration.

Level of Evidence

NA Laryngoscope, 2017

http://ift.tt/2Ak2kZ9

Development and external validation of a risk-prediction model to predict 5-year overall survival in advanced larynx cancer

Objectives/Hypothesis

TNM-classification inadequately estimates patient-specific overall survival (OS). We aimed to improve this by developing a risk-prediction model for patients with advanced larynx cancer.

Study Design

Cohort study.

Methods

We developed a risk prediction model to estimate the 5-year OS rate based on a cohort of 3,442 patients with T3T4N0N+M0 larynx cancer. The model was internally validated using bootstrapping samples and externally validated on patient data from five external centers (n = 770). The main outcome was performance of the model as tested by discrimination, calibration, and the ability to distinguish risk groups based on tertiles from the derivation dataset. The model performance was compared to a model based on T and N classification only.

Results

We included age, gender, T and N classification, and subsite as prognostic variables in the standard model. After external validation, the standard model had a significantly better fit than a model based on T and N classification alone (C statistic, 0.59 vs. 0.55, P < .001). The model was able to distinguish well among three risk groups based on tertiles of the risk score. Adding treatment modality to the model did not decrease the predictive power. As a post hoc analysis, we tested the added value of comorbidity as scored by American Society of Anesthesiologists score in a subsample, which increased the C statistic to 0.68.

Conclusions

A risk prediction model for patients with advanced larynx cancer, consisting of readily available clinical variables, gives more accurate estimations of the estimated 5-year survival rate when compared to a model based on T and N classification alone.

Level of Evidence

2c Laryngoscope, 2017

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Cricothyroid joint type as predictor for vocal fold elongation in professional singers

Objective

Vocal fold (VF) elongation vocal folds depends on two factors: the activity of the laryngeal muscles and the cricothyroid joint (CTJ). The aim of the study was to show the influence of the CTJ on VF elongation while singing a sustained vowel at different pitches.

Study Design

Prospective study.

Methods

Forty-nine female professional singers (25 sopranos, 24 altos) were recruited. Three-dimensional images of the larynx derived from high-resolution computed tomography scanning were obtained at the mean speaking fundamental frequency (F0) and one (F1) and two octaves (F2) above this pitch.

Results

From F0 to F1, all three CTJ types showed equal elongation of the VF (type A: 14%, type B/C: 13%). From F1 to F2, VF elongation was 8% in singers with type A and 4% in those with type B/C (P < 0.0001).

Conclusion

The stability of the CTJ directly influences VF during singing. This is the first study to show this relationship in vivo.

Level of Evidence

4. Laryngoscope, 2017

http://ift.tt/2AiDQj5

Lack of long-term add-on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps

Objectives/Hypothesis

Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add-on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking.

Study Design

Prospective, randomized, open-label trial.

Methods

In this trial with long-term follow-up, we evaluated the efficacy of montelukast as an add-on treatment to INCS in postoperative CRS with nasal polyp (CRSwNP) patients. CRSwNP patients (N = 72) undergoing endoscopic sinus surgery were randomized in two arms for the postoperative treatment. One group (N = 36) received INCS in monotherapy, whereas the other group (N = 36) received INCS in association with montelukast for 1 year. The efficacy of montelukast with INCS was evaluated by assessing both subjective (total five-symptom score [T5SS]) and objective (nasal polyp score [NPS], Lund-Mackay [LMK] score, and subjective olfactometry [Barcelona Smell Test 24]) outcome parameters and compared with the gold standard of INCS in monotherapy.

Results

After 1 year of surgery, T5SS, NPS, and LMK score were significantly reduced in patients treated with either INCS or INCS plus montelukast, without significant differences between the two treatment arms. Improvement of smell loss by olfactometry was also observed with no differences between arms. Similar findings were observed at 3 and 6 months.

Conclusions

These results suggest that the addition of montelukast to INCS should not be recommended in the treatment of postoperative CRSwNP patients.

Level of Evidence

1b Laryngoscope, 2017

http://ift.tt/2hRLRVl

Cough strength and expiratory force in aspirating and nonaspirating postradiation head and neck cancer survivors

Objective

Expiratory functions that clear aspiration from the airway are compromised in patients with neurogenic dysphagia for whom cough and expiratory force may be impaired by the primary disease process. The relationship between expiratory function, cough, and aspiration is less clear in head and neck cancer (HNC) survivors for whom the disease process does not directly impact the lower respiratory system. Our objective was to compare mechanisms of airway clearance (expiratory force and cough) with aspiration status in postradiated HNC survivors.

Study Design

Cross-sectional study.

Methods

One hundred and three disease-free HNC survivors ≥ 3-months postradiotherapy referred for modified barium swallow studies were prospectively enrolled regardless of dysphagia status. Maximum expiratory pressures (MEPs) and peak cough flow (PCF) measures were taken at enrollment and examined as a function of aspiration status using generalized linear regression methods.

Results

Thirty-four (33%) patients aspirated. Maximum expiratory pressure and PCF demonstrated a moderate positive correlation (Pearson's r = 0.35). Adjusting for sex and age, MEPs were on average 19.2% lower (21.1 cm H₂O, 95% confidence interval [CI] 5.3, 36.8) among aspirators. Peak cough flow was also 14.9% lower (59.6 L/minute, 95% CI 15.8, 103.3) among aspirators after adjusting for age and sex.

Conclusion

Expiratory functions were depressed in postradiated HNC aspirators relative to nonaspirators, suggesting that airway protection impairments may extend beyond disrupted laryngopharyngeal mechanisms in the local treatment field. Exercises to strengthen subglottic expiratory force-generating capacity may offer an adjunctive therapeutic target to improve airway protection in chronic aspirators after head and neck radiotherapy.

Level of Evidence

2b. Laryngoscope, 2017

http://ift.tt/2Ak2hMX

Examination of olfactory training effectiveness in relation to its complexity and the cause of olfactory loss

Objective

Although the effectiveness of olfactory training (OT) had already been documented, the optimal regimen for such training remains unexplored. We examined whether the complexity of OT, namely alteration of odor quantity and quality, increases its effectiveness.

Design

One-hundred eight patients (M_age = 60.1 ± 1) with postinfectious (n = 57) or idiopathic (n = 51) olfactory dysfunction underwent OT preceded and followed by examination of olfactory function.

Methods

Subjects were randomly assigned to one of the three experimental conditions: 1) simple training comprising four basic, single-molecule substances; 2) complex training involving four odor mixtures; and 3) odor-altering training in which patients changed sets of mixtures every 2 months.

Results

The analysis of variance revealed that the benefit seen in this sample was not affected by the complexity of OT with regard to odor mixtures or alteration of odor type. The highest increase of the Sniffin' Sticks (Burghardt GmbH; Wedel, Germany) threshold, discrimination, and identification (and overall TDI) score was observed in postinfectious patients.

Conclusion

We conclude that the outcomes of OT are not strongly influenced by the training regimen. However, further investigation of OT regimens is required, particularly with regard to training duration.

Level of Evidence

2b. Laryngoscope, 2017

http://ift.tt/2hRLPgb

3-O-Glyceryl-2-O-hexyl ascorbate suppresses melanogenesis by interfering with intracellular melanosome transport and suppressing tyrosinase protein synthesis

Summary

Background

Ascorbic acid (AsA) has multifunctional benefits on skin beauty, such as the reduction in oxidative stress and the induction of collagen production. Among them, the prevention and improvement of skin pigmentation by AsA is a most important benefit for people. However, it is well known that AsA not only is quite unstable in formulations but it also has a low capability of skin penetration due to its hydrophilic property. In addition, existing water-soluble AsA derivatives that were developed to improve its stability also have low skin penetration.

Aim

To investigate the potential of a newly synthesized amphiphilic derivative of AsA, 3-O-Glyceryl-2-O-hexyl ascorbate (VC-HG), which has an added glyceryl group and a hexyl group, on skin beauty focusing on its skin lightening/whitening effects.

Methods

DNA microarray analysis and real-time PCR were used to clarify the effects of VC-HG on melanogenesis using B16 mouse melanoma cells. The effects of VC-HG on melanin synthesis, tyrosinase protein levels, and the inhibition of tyrosinase activity were evaluated.

Results

DNA microarray analysis revealed that treatment with VC-HG downregulated the expression of genes encoding tyrosinase and MyosinVa. Further, real-time PCR analysis showed the downregulation of tyrosinase, MyosinVa, Rab27a, and Kinesin mRNAs following VC-HG treatment. In addition, VC-HG caused decreases in tyrosinase protein levels and melanin synthesis.

Conclusion

We conclude that VC-HG has an impact on skin lightening/whitening by inhibiting tyrosinase protein synthesis and interfering with intracellular melanosome transport.

http://ift.tt/2AqhQnc

Delayed Intraventricular Hemorrhage following a Ventriculoperitoneal Shunt Placement: Exploring the Surgical Anatomy of a Rare Complication

Ventriculoperitoneal shunt (VPS) placement is one of the commoner neurosurgical procedures worldwide. The purpose of this article is to report a case of delayed intraventricular hemorrhage (IVH) following a VPS and to review the literature regarding anatomic factors that could potentially explain this rare complication. A 78-year-old man with normal pressure hydrocephalus, who underwent an uneventful right VPS placement, suffered from a catastrophic isolated IVH five days later. The reported cases of delayed intracerebral hemorrhage (ICH) following VPS are rare and those with IVH are even rarer. Potential factors of surgical anatomy that could cause delayed ICH/IVH following a VPS procedure include erosion of vasculature by catheter cannulation, multiple attempts at perforation, puncture of the choroid plexus, improper placement of the tubing within the brain parenchyma, VPS system revision, venous infarction, vascular malformations, head trauma, and brain tumors. Other causes include generalized convulsion, VPS system malfunction, increased intracranial or blood pressure, sudden intracranial hypotension, and bleeding disorders. According to the current literature, our case is the first reported delayed isolated IVH after a VPS placement so far. Neurosurgeons should be aware of the delayed ICH/IVH as a rare, potentially fatal complication of VPS, as well as of its risk factors.

http://ift.tt/2AqpPk5

Thyroid High-Impact Articles

FREE ACCESS through November 21, 2017.
Read now:

Latest Impact Factor: 5.515
The Official Journal of: American Thyroid Association

The 2017 Bethesda System for Reporting Thyroid Cytopathology
Edmund S. Cibas, Syed Z. Ali 

The Role of Chemokines in Thyroid Carcinoma
Sharinie Yapa, Omar Mulla, Victoria Green, James England, John Greenman 

Childhood Thyroid Function Reference Ranges and Determinants: A Literature Overview and a Prospective Cohort Study
Ibrahim Önsesveren, Mirjana Barjaktarovic, Layal Chaker, Yolanda B. de Rijke, Vincent W.V. Jaddoe, Hanneke M. van Santen, Theo J. Visser, Robin P. Peeters, Tim I.M. Korevaar 

Temporal Changes in Thyroid Nodule Volume: Lack of Effect on Paranodular Thyroid Tissue Volume
Giorgio Grani, Rocco Bruno, Giuseppe Lucisano, Giuseppe Costante, Domenico Meringolo, Efisio Puxeddu, Massimo Torlontano, Salvatore Tumino, Marco Attard, Livia Lamartina, Antonio Nicolucci, David S. Cooper, Sebastiano Filetti, Cosimo Durante 

Projecting Survival in Papillary Thyroid Cancer: A Comparison of the Seventh and Eighth Editions of the American Joint Commission on Cancer/Union for International Cancer Control Staging Systems in Two Contemporary National Patient Cohorts
Lauren N. Pontius, Taofik O. Oyekunle, Samantha M. Thomas, Michael T. Stang, Randall P. Scheri, Sanziana A. Roman, Julie A. Sosa 

Automated MicroSPECT/MicroCT Image Analysis of the Mouse Thyroid Gland
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel H. Shen, Kimerly Powell, Sean C. Smart, John Beech, Xiaochao Sheng, Lawrence S. Kirschner, Chia-Hsiang Menq, Sissy M. Jhiang 

The post <i>Thyroid</i> High-Impact Articles appeared first on American Thyroid Association.

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Immunologic, microbial, and epithelial interactions in atopic dermatitis

To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis.

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Home-based program of maintaining unresponsiveness in children with allergic reactions to larger amounts of peanuts

Allergists currently advise most patients with peanut allergy to observe life-long avoidance. This is in contrast to milk and egg allergy, where many children are partly tolerant to the food and tolerance induction with food ladders is routine.1 Twenty-one percent of children with proven peanut allergy at challenges appear to outgrow their clinical reactivity.2 Furthermore, clinical trials using oral, subcutaneous, and epicutaneous peanut immunotherapy have demonstrated that patients vary in the amount of peanut needed to trigger a reaction and that desensitization and to some extent sustained unresponsiveness can be achieved in children and adolescents.

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P237 Real world effects of reslizumab: a retrospective chart review

Reslizumab was recently approved for certain patients with asthma. This study compares asthma control before and during treatment in a California allergy clinic.

http://ift.tt/2yESUvc

PRACTICAL MANAGEMENT OF ACNE FOR CLINICIANS An International Consensus from the Global Alliance to Improve Outcomes in Acne

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Rosacea and alcohol intake

To the Editor: The paper by Li1 on alcohol intake and risk for rosacea prompted us to make some considerations and report our experience. We previously showed that rosacea patients have a significantly higher prevalence of small intestinal bacterial overgrowth (SIBO) than controls and that SIBO eradication significantly improved their lesions.2,3 Later, we investigated the role of various microorganisms in rosacea, with a 3-year follow-up of patients that had been treated.4 Demodex folliculorum, Helicobacter pylori, and SIBO were examined and all played a pathogenic role; SIBO prevailed in papulopustular rosacea, H.

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A New Editor for Jaad

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It is vital to identify the underlying cause of chronic laryngopharyngeal neuropathy

We reviewed, with great interest, the paper entitled "Randomized double blind trial of amitriptyline versus placebo in treatment of chronic laryngopharyngeal neuropathy," by Jang et al. [1]. This is an excellent work. The authors found that subjective laryngopharyngeal symptoms improved in 67% patients of an amitriptyline group and in 44% patients of a placebo group. However, we believe that the inclusion criteria and exclusion criteria were somewhat inappropriate. Also, the measures of clinical outcomes could have been improved.

http://ift.tt/2zpYa2M

Adenoidectomy and chronic nasal obstruction developing after failure of nasal steroid therapy

We reviewed, with great interest, the paper entitled "Role of adenoidectomy in chronic nasal obstruction after nasal steroid therapy failure" by Ciolek et al. [1]. This is excellent work. In the study, the authors document an average rate of respiratory allergies, but a high rate of asthma, among patients who fail nasal steroid therapy to treat chronic nasal obstructions. The authors suggest that adenoidectomy was highly efficacious in this subset of patients. However, adenoidectomy may not be necessary.

http://ift.tt/2ye8ucN

Sigmoid volvulus in children: a case report

Sigmoid volvulus is frequently reported in the "volvulus belt" (Middle East, Africa, the Indian subcontinent, Turkey, and South America) and is the third leading cause of large bowel obstruction in North America.

http://ift.tt/2j7wziN

Lingual metastasis as an initial presentation of renal cell carcinoma: a case report

Renal cell carcinoma is the third most common tumor that metastasizes to the head and neck, after breast and lung carcinomas. Tongue metastasis as an initial presentation of renal cell carcinoma is extremely r...

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Factors Associated With Remission of Skin Disease in Dermatomyositis

This cohort study examines factors associated with clinical remission of skin disease in dermatomyositis.

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Risk factors for tooth loss in middle and older age after up to 10 years: An observational cohort study

Publication date: Available online 6 November 2017
Source:Archives of Oral Biology
Author(s): Alexander Jochen Hassel, Volkan Safaltin, Sabine Grill, Johannes Schröder, Hans-Werner Wahl, Anna-Luisa Klotz, Edriss Habibi, Peter Rammelsberg, Andreas Zenthöfer
ObjectiveThe objective of this research was to identify risk factors for tooth loss in two older birth cohorts, quinquagenarians and septuagenarians, after up to 10 years of clinical observation.DesignOne hundred and twenty-three participants were recruited from the Interdisciplinary Study of Adult Development (ILSE) and examined at baseline and up to 10 years after. Thirty-nine and 84 participants belonged to the older (OC; born in 1930/32) cohort and younger (YC; born in 1950/52) cohort, respectively. Each participant underwent a dental examination comprising evaluation of the dental status (number of teeth, prosthetic restorations), Plaque Index (PI), Gingival Index (GI), DMF-S, periodontal probing depths (PD) and tooth mobility (TM). Incidence of tooth loss over the study period was calculated for both cohorts as well as for the grouped dental target variables. A logistic regression model for tooth loss (0=tooth present/1=tooth lost) was compiled with possible binary confounders.ResultsDuring the study period, 1.2 (1.9) and 2.6 (2.6) teeth were lost in YC and OC, respectively, reflecting correspondent loss rates of 5% and 14% (p<0.001). However, primarily TM >1 merged into substantial tooth loss (60%). The regression analysis confirmed the bivariate findings. Middle- and older-aged people, quinquagenarians and septuagenarians, show relevant tooth loss. Older age and worse oral health issues were identified as risk factors for tooth loss (p<0.007).ConclusionsThe predominant predictor of tooth loss seems to be tooth mobility. With the rising challenges due to aging in several societies, knowing the risks might help clinicians when weighing treatment strategies and should encourage refining preventive measures for older patients.



http://ift.tt/2hbv1zX

Correction to Supporting Information for Brown and Sivak, Allocating dissipation across a molecular machine cycle to maximize flux [SI Correction]

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction to Supporting Information for "Allocating dissipation across a molecular machine cycle to maximize flux," by Aidan I. Brown and David A. Sivak, which was first published October 3, 2017; 10.1073/pnas.1707534114 (Proc Natl Acad Sci USA 114:11057–11062). The authors note that, due to a printer's error,...

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Correction for Salguero-Gomez et al., Fast-slow continuum and reproductive strategies structure plant life-history variation worldwide [Correction]

POPULATION BIOLOGY Correction for "Fast–slow continuum and reproductive strategies structure plant life-history variation worldwide," by Roberto Salguero-Gómez, Owen R. Jones, Eelke Jongejans, Simon P. Blomberg, David J. Hodgson, Cyril Mbeau-Ache, Pieter A. Zuidema, Hans de Kroon, and Yvonne M. Buckley, which was first published December 22, 2015; 10.1073/pnas.1506215112 (Proc Natl...

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Correction for Koster et al., Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA [Correction]

MICROBIOLOGY Correction for "Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA," by Stefan Köster, Sandeep Upadhyay, Pallavi Chandra, Kadamba Papavinasasundaram, Guozhe Yang, Amir Hassan, Steven J. Grigsby, Ekansh Mittal, Heidi S. Park, Victoria Jones, Fong-Fu Hsu, Mary Jackson, Christopher M. Sassetti, and Jennifer...

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Correction for Tong et al., IgH isotype-specific B cell receptor expression influences B cell fate [Correction]

IMMUNOLOGY AND INFLAMMATION Correction for "IgH isotype-specific B cell receptor expression influences B cell fate," by Pei Tong, Alessandra Granato, Teng Zuo, Neha Chaudhary, Adam Zuiani, Seung Seok Han, Rakesh Donthula, Akritee Shrestha, Debattama Sen, Jennifer M. Magee, Michael P. Gallagher, Cees E. van der Poel, Michael C. Carroll, and...

http://ift.tt/2zrkwBb

Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism [Systems Biology]

Alternative splicing plays important roles in generating different transcripts from one gene, and consequently various protein isoforms. However, there has been no systematic approach that facilitates characterizing functional roles of protein isoforms in the context of the entire human metabolism. Here, we present a systematic framework for the generation of...

http://ift.tt/2ydojQQ

GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs [Evolution]

Receptor activity-modifying proteins (RAMPs) are widely expressed in human tissues and, in some cases, have been shown to affect surface expression or ligand specificity of G-protein–coupled receptors (GPCRs). However, whether RAMP−GPCR interactions are widespread, and the nature of their functional consequences, remains largely unknown. In humans, there are three RAMPs...

http://ift.tt/2AhyKDT

PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP [Cell Biology]

Apoptosis and necroptosis are two distinct cell death mechanisms that may be activated in cells on stimulation by TNFα. It is still unclear, however, how apoptosis and necroptosis may be differentially regulated. Here we screened for E3 ubiquitin ligases that could mediate necroptosis. We found that deficiency of Pellino 1...

http://ift.tt/2AoxqzT

Rising hazard of storm-surge flooding [Earth, Atmospheric, and Planetary Sciences]

The 2017 Atlantic hurricane season is one for the history books. It has blown a number of records out of the water. Harvey dumped more rain on the United States than any previous hurricane. Irma maintained the highest category 5 longer than any storm anywhere in the world. September 2017...

http://ift.tt/2Ar24IU

Reduction of solar photovoltaic resources due to air pollution in China [Sustainability Science]

Solar photovoltaic (PV) electricity generation is expanding rapidly in China, with total capacity projected to be 400 GW by 2030. However, severe aerosol pollution over China reduces solar radiation reaching the surface. We estimate the aerosol impact on solar PV electricity generation at the provincial and regional grid levels in...

http://ift.tt/2j66QHo

Helicase SPRNTing through the nanopore [Biophysics and Computational Biology]

Enzymes that move directionally on single-stranded nucleic acids are at the core of emerging nanopore sequencing technology. Of a particular use are DNA helicases, molecular motors that bind single-stranded DNA (ssDNA) independently of its sequence and use ATP to fuel their directional motion along the DNA (1). In nanopore-based sequencing,...

http://ift.tt/2Ar22AM

Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest [Developmental Biology]

Most of the enteric nervous system derives from the "vagal" neural crest, lying at the level of somites 1–7, which invades the digestive tract rostro-caudally from the foregut to the hindgut. Little is known about the initial phase of this colonization, which brings enteric precursors into the foregut. Here we...

http://ift.tt/2Asle10

Controlling orientational order in block copolymers using low-intensity magnetic fields [Applied Physical Sciences]

The interaction of fields with condensed matter during phase transitions produces a rich variety of physical phenomena. Self-assembly of liquid crystalline block copolymers (LC BCPs) in the presence of a magnetic field, for example, can result in highly oriented microstructures due to the LC BCP's anisotropic magnetic susceptibility. We show...

http://ift.tt/2Ar223K

Conductivity and dissociation in liquid metallic hydrogen and implications for planetary interiors [Physics]

Liquid metallic hydrogen (LMH) is the most abundant form of condensed matter in our solar planetary structure. The electronic and thermal transport properties of this metallic fluid are of fundamental interest to understanding hydrogen's mechanism of conduction, atomic or pairing structure, as well as the key input for the magnetic...

http://ift.tt/2j88kks

Clinical validation of a nanodiamond-embedded thermoplastic biomaterial [Engineering]

Detonation nanodiamonds (NDs) are promising drug delivery and imaging agents due to their uniquely faceted surfaces with diverse chemical groups, electrostatic properties, and biocompatibility. Based on the potential to harness ND properties to clinically address a broad range of disease indications, this work reports the in-human administration of NDs through...

http://ift.tt/2Ar20Ja

Strong attractions and repulsions mediated by monovalent salts [Biophysics and Computational Biology]

Controlling interactions between proteins and nanoparticles in electrolyte solutions is crucial for advancing biological sciences and biotechnology. The assembly of charged nanoparticles (NPs) and proteins in aqueous solutions can be directed by modifying the salt concentration. High concentrations of monovalent salt can induce the solubilization or crystallization of NPs and...

http://ift.tt/2AnUbnn

Three-dimensional mesostructures as high-temperature growth templates, electronic cellular scaffolds, and self-propelled microrobots [Engineering]

Recent work demonstrates that processes of stress release in prestrained elastomeric substrates can guide the assembly of sophisticated 3D micro/nanostructures in advanced materials. Reported application examples include soft electronic components, tunable electromagnetic and optical devices, vibrational metrology platforms, and other unusual technologies, each enabled by uniquely engineered 3D architectures. A...

http://ift.tt/2Ar1WsU

KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype [Cell Biology]

The inositol pyrophosphates 5-InsP7 (diphosphoinositol pentakisphosphate) and 1,5-InsP8 (bis-diphosphoinositol tetrakisphosphate) are highly energetic cellular signals interconverted by the diphosphoinositol pentakisphosphate kinases (PPIP5Ks). Here, we used CRISPR to KO PPIP5Ks in the HCT116 colon cancer cell line. This procedure eliminates 1,5-InsP8 and raises 5-InsP7 levels threefold. Expression of p53 and p21...

http://ift.tt/2j8eAbY

Neurobiology of culturally common maternal responses to infant cry [Psychological and Cognitive Sciences]

This report coordinates assessments of five types of behavioral responses in new mothers to their own infants' cries with neurobiological responses in new mothers to their own infants' cries and in experienced mothers and inexperienced nonmothers to infant cries and other emotional and control sounds. We found that 684 new...

http://ift.tt/2AqSB47

Evolutionary cascades induced by large frugivores [Ecology]

Large, fruit-eating vertebrates have been lost from many of the world's ecosystems. The ecological consequences of this defaunation can be severe, but the evolutionary consequences are nearly unknown because it remains unclear whether frugivores exert strong selection on fruit traits. I assessed the macroevolution of fruit traits in response to...

http://ift.tt/2AnUazP

Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity [Agricultural Sciences]

Uncoupling protein 1 (UCP1) is localized on the inner mitochondrial membrane and generates heat by uncoupling ATP synthesis from proton transit across the inner membrane. UCP1 is a key element of nonshivering thermogenesis and is most likely important in the regulation of body adiposity. Pigs (Artiodactyl family Suidae) lack a...

http://ift.tt/2Apwzii

Pathologic Reporting of Tall-Cell Variant of Papillary Thyroid Cancer: Have We Reached a Consensus?

Thyroid , Vol. 0, No. 0.


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Adenoidectomy and chronic nasal obstruction developing after failure of nasal steroid therapy

Publication date: Available online 7 November 2017
Source:American Journal of Otolaryngology
Author(s): Zhengcai Lou




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Cultural Competence in Global Health

By Nathan Douthit

[I]n the…aim to produce cultural competence, one dimension to be avoided is… narrowly defining competence… in its traditional sense: an easily demonstrable mastery of a finite body of knowledge. Rather, cultural competence…is best described… as a commitment and active engagement in a lifelong process that individuals enter into on an ongoing basis with patients, communities, colleagues, and with themselves.^[1]

            Dunton et al describe the importance of cultural competence in taking care of patients in minority communities in "Navigating care for Bedouin patients with diabetes." They describe the case of a patient with a 30 year history of diabetes. Despite his best efforts, the doctor's success when, "encouraging the patient to make lifestyle changes… proved virtually impossible." He developed End Stage Renal Disease as a result, and then suddenly passed away, likely secondary to "a heart attack due to complications from chronic diabetes."

            In light of the rise of chronic disease, specifically as demonstrated in a "minority culture within a larger Western society," the training of culturally competent physicians is essential. In this case, fatalism plays a key role. The eldest son writes,

            "During my father's disease, his socioeconomic situation was good…. He could go to the experts…. [But] he didn't consider diabetes a major threat. He was shocked when he was told he needed dialysis. He initially refused treatment for a few weeks before we convinced him with the help of his doctor…. We were sorry that he died. But in our society, we believe in God and see this as the will of God. We can't do anything about it."

            Addressing fatalism, a "main obstacle in educating and motivating patients," requires a culturally sensitive dialogue. The authors recommend focusing on quality of life rather than threat of death. Having patients "consider how changes in lifestyle will help in remaining strong and active until the prewritten day of death," may help in addressing this issue.

            According to the authors, "the link between trust and the adherence to treatment regimens is found within many communities." Training culturally competent physicians must focus on having knowledge, skills, and respect and being able to implement these effectively in cross cultural situations.^[2] "Culturally appropriate intervention channels" are key to reducing stigma and raising patient awareness of available resources.

            Cultural competence has been shown to improve many health behaviors, specifically related to nutrition, exercise and substance use habits.^[3] Culturally competent physicians must be willing to partner with local leaders. As the authors write, "if community and leaders could establish the importance of diet as something on par with the importance of vaccinations, it would contribute to changing the culture positively."

BMJ Case Reports invites authors to publish cases regarding cultural competence and humility in training global health practitioners. Global health case reports can emphasize:

            -The effects of culturally appropriate health interventions

            -Training methods for culturally competent global health practitioners

            -Disease spread or exacerbation as a result of cultural incompetence

            -Innovation in culturally appropriate interventions

Manuscripts may be submitted by students, physicians, nurses or other medical professionals to BMJ Case Reports. For more information, review the blog on how to write a global health case report.

Read more about cultural competence and humility in the interaction of clinicians with patients at BMJ Case Reports

            –A Rohingya refugee's journey in Australia and the barriers to accessing healthcare

            –Ethiopian-Israeli community

            –Analysis of the psychosocial impact of caretaking on the parents of an infant with severe congenital heart defect.

Read more about cultural competence and humility from other sources

            -Tervalon M, Murray-Garcia J. Cultural humility versus cultural competence: a critical distinction in defining physician training outcomes in multicultural education. Journal of health care for the poor and underserved. 1998;9(2):117-25.

            -Brach C, Fraserirector I. Can cultural competency reduce racial and ethnic health disparities? A review and conceptual model. Medical Care Research and Review. 2000 Nov;57(1_suppl):181-217

            -Goode TD, Dunne MC, Bronheim S. The evidence base for cultural and linguistic competency in health care. New York^ eNY NY: Commonwealth Fund; 2006 Oct.

^[1] Tervalon M, Murray-Garcia J. Cultural humility versus cultural competence: a critical distinction in defining physician training outcomes in multicultural education. Journal of health care for the poor and underserved. 1998;9(2):117-25.

^[2] Brach C, Fraserirector I. Can cultural competency reduce racial and ethnic health disparities? A review and conceptual model. Medical Care Research and Review. 2000 Nov;57(1_suppl):181-217.

^[3] Goode TD, Dunne MC, Bronheim S. The evidence base for cultural and linguistic competency in health care. New York^ eNY NY: Commonwealth Fund; 2006 Oct.

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European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery

No abstract available

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European guidelines on perioperative venous thromboembolism prophylaxis: Surgery during pregnancy and the immediate postpartum period

No abstract available

http://ift.tt/2yerPL3

European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary

No abstract available

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European guidelines on perioperative venous thromboembolism prophylaxis: Day surgery and fast-track surgery

No abstract available

http://ift.tt/2ydAJs7

European guidelines on perioperative venous thromboembolism prophylaxis: Intensive care

No abstract available

http://ift.tt/2zoVOBn

European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the obese patient

No abstract available

http://ift.tt/2yf8fyc

European guidelines on perioperative venous thromboembolism prophylaxis: Cardiovascular and thoracic surgery

No abstract available

http://ift.tt/2zpmRMQ

European guidelines on perioperative venous thromboembolism prophylaxis: Chronic treatments with antiplatelet agents

No abstract available

http://ift.tt/2yf7Zze

European guidelines on perioperative venous thromboembolism prophylaxis: Aspirin

No abstract available

http://ift.tt/2zooPNi

European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding

No abstract available

http://ift.tt/2yf7OE4

European guidelines on perioperative venous thromboembolism prophylaxis: Mechanical prophylaxis

No abstract available

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European guidelines on perioperative venous thromboembolism prophylaxis: Inferior vena cava filters

No abstract available

http://ift.tt/2ye4I3c

European guidelines on perioperative venous thromboembolism prophylaxis

No abstract available

http://ift.tt/2zotyP6

Iguratimod ameliorates inflammatory responses by modulating the Th17/Treg paradigm in dextran sulphate sodium-induced murine colitis

Publication date: January 2018
Source:Molecular Immunology, Volume 93
Author(s): Xue-pei Jiang, Xie-lin Huang, Zao-peng Yang, Shun-cai Wang, Wei Xie, Lei Miao, Li Tang, Zhi-ming Huang
Inflammatory bowel disease (IBD) is an autoimmune disease with an abnormal and persistent immune response. Iguratimod, a novel anti-rheumatic drug, exhibits anti-inflammatory effects and regulates immune response. The role of iguratimod in intestinal mucosal inflammation and immunity has not been examined. The aim of this study was to investigate whether iguratimod ameliorates dextran sulphate sodium (DSS)-induced murine colitis and its potential regulatory mechanism. Murine colitis was induced by administering 2.5% DSS for 5days. Some mice were administered iguratimod (5, 30mg/kg) by oral gavage once daily for 7days, beginning on the day 3 after colitis induction. Our study showed that iguratimod alleviates the symptoms of colitis and suppresses intestinal tissue damage, including macroscopic and histopathological manifestations. Moreover, iguratimod reduced interleukin (IL)-6, IL-17, and tumour necrosis factor-α levels, and increased the expression levels of IL-10 and TGF-β. In addition, iguratimod downregulated the proportion of Th17 cells, the level of transcription factor retinoic acid-related orphan receptor γt (RORγt), and the phosphorylation of signal transducer and activator of transcription-3 (STAT3), and upregulated the proportion of Treg cells, the level of transcription factor forkhead box p3 (Foxp3), and the phosphorylation of STAT5 in the colonic tissues. In conclusion, iguratimod plays a protective role in mice with DSS-induced colitis via anti-inflammatory effects and regulation of Th17/Treg cells. Therefore, use of iguratimod may serve as a novel therapeutic strategy for the treatment of IBD.



http://ift.tt/2j8nt5q

GIFT-Grab: Real-time C++ and Python multi-channel video capture, processing and encoding API

Shakir, DCS; Garcia Peraza Herrera, LC; Daga, P; Doel, T; Clarkson, MJ; Ourselin, S; Vercauteren, T; (2017) GIFT-Grab: Real-time C++ and Python multi-channel video capture, processing and encoding API. Journal of Open Research Software , 5 (1) , Article 27. 10.5334/jors.169 . Green open access

http://ift.tt/2hmPCVL

Delirium, frailty and mortality: interactions in a prospective study of hospitalized older people

Dani, M; Owen, L; Jackson, TA; Rockwood, K; Sampson, E; Davis, DHJ; (2018) Delirium, frailty and mortality: interactions in a prospective study of hospitalized older people. Journals of Gerontology - Series A Biological Sciences and Medical Sciences 10.1093/gerona/glx214 . (In press). Green open access

http://ift.tt/2zlGFDn

Molecular gerontology: Towards healthy aging

Castillo-Quan, JI; Kinghorn, KJ; (2013) Molecular gerontology: Towards healthy aging. Gaceta Medica de Mexico , 149 (6) pp. 680-685.

http://ift.tt/2hjPfvn

Periprocedural outcomes after surgical revascularization and stenting for postradiotherapy carotid stenosis.

Kasivisvanathan, V; Thapar, A; Davies, KJ; Dharmarajah, B; Shalhoub, J; Davies, AH; (2012) Periprocedural outcomes after surgical revascularization and stenting for postradiotherapy carotid stenosis. J Vasc Surg , 56 (4) 1143-52.e2. 10.1016/j.jvs.2012.04.044 .

http://ift.tt/2zjRN3n

Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation

Hoffmann, F; Puetz, VB; Viding, E; Sethi, A; Palmer, A; McCrory, EJ; (2017) Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive and Affective Neuroscience 10.1093/scan/nsx124 . (In press). Green open access

http://ift.tt/2hmPvJP

The pet factor--companion animals as a conduit for getting to know people, friendship formation and social support.

Wood, L; Martin, K; Christian, H; Nathan, A; Lauritsen, C; Houghton, S; Kawachi, I; Wood, L; Martin, K; Christian, H; Nathan, A; Lauritsen, C; Houghton, S; Kawachi, I; McCune, S; - view fewer (2015) The pet factor--companion animals as a conduit for getting to know people, friendship formation and social support. PLoS One , 10 (4) , Article e0122085. 10.1371/journal.pone.0122085 .

http://ift.tt/2zlGBn7

A ratchet made of tiny magnets

Bramwell, ST; (2017) A ratchet made of tiny magnets. Nature Materials , 16 (11) pp. 1053-1054. 10.1038/nmat5004 .

http://ift.tt/2hjPbvD

Rural protein insufficiency in a wildlife-depleted west African farm-forest landscape

Schulte-Herbrüggen, B; Cowlishaw, G; Homewood, K; Rowcliffe, M; (2018) Rural protein insufficiency in a wildlife-depleted west African farm-forest landscape. PLoS ONE (In press).

http://ift.tt/2zlGvvL

Myasthenia gravis - treatment of acute severe exacerbations in the intensive care unit results in a favourable long-term prognosis

Spillane, J; Hirsch, NP; Kullmann, DM; Taylor, C; Howard, RS; (2014) Myasthenia gravis - treatment of acute severe exacerbations in the intensive care unit results in a favourable long-term prognosis. European Journal of Neurology , 21 (1) pp. 171-173. 10.1111/ene.12115 .

http://ift.tt/2hjP7Mp

Temporal-difference search in Computer Go

Silver, D; Sutton, R; Müller, M; (2013) Temporal-difference search in Computer Go. In: (pp. pp. 486-487).

http://ift.tt/2zlGqrX

The dark side of antihormonal action in breast cancer

Gee, JMW; Stone, A; McClelland, RA; Hiscox, S; Hutcheson, IR; Jordan, NJ; Fiegl, HM; ... Nicholson, RI; + view all Gee, JMW; Stone, A; McClelland, RA; Hiscox, S; Hutcheson, IR; Jordan, NJ; Fiegl, HM; Widschwendter, M; Shaw, VE; Barrow, D; Nicholson, RI; - view fewer (2009) The dark side of antihormonal action in breast cancer. In: Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets. (pp. 63-83).

http://ift.tt/2hjOZwp

Clinical Pediatric Endocrinology: Fifth Edition

Brook, CGD; Clayton, PE; Brown, RS; Savage, MO; (2007) Clinical Pediatric Endocrinology: Fifth Edition.

http://ift.tt/2zlGkR7

Quantifying the anisotropy and tortuosity of permeable pathways in clay-rich mudstones using models based on X-ray tomography

Backeberg, NR; Iacoviello, F; Rittner, M; Mitchell, TM; Jones, AP; Day, R; Wheeler, J; ... Striolo, A; + view all Backeberg, NR; Iacoviello, F; Rittner, M; Mitchell, TM; Jones, AP; Day, R; Wheeler, J; Shearing, PR; Vermeesch, P; Striolo, A; - view fewer (2017) Quantifying the anisotropy and tortuosity of permeable pathways in clay-rich mudstones using models based on X-ray tomography. Scientific Reports , 7 (1) , Article 14838. 10.1038/s41598-017-14810-1 . Green open access

http://ift.tt/2hjZvDz

Lower urinary tract symptoms that predict microscopic pyuria

Khasriya, R; Barcella, W; De Iorio, M; Swamy, S; Gill, K; Kupelian, A; Malone-Lee, J; (2017) Lower urinary tract symptoms that predict microscopic pyuria. International Urogynecology Journal 10.1007/s00192-017-3472-7 . (In press). Green open access

http://ift.tt/2zlGdFb

Ultimate limit state design technology for aluminum multi-hull ship structures

Paik, JK; Hughes, OF; Hess, PE; Renaud, C; (2006) Ultimate limit state design technology for aluminum multi-hull ship structures. In:

http://ift.tt/2hjZrUl

Outcome after inpatient rehabilitation for patients with functional movement disorders

Batla, A; Bhatia, KP; Fisher, L; Joyce, EM; Price, G; Edwards, MJ; (2013) Outcome after inpatient rehabilitation for patients with functional movement disorders. In: (pp. S426-S426). WILEY-BLACKWELL

http://ift.tt/2zlor4A

DDR1 localisation to adherens junctions prevents efficient clustering of supernumerary centrosomes.

Rhys, AD; Vaghela, M; Monteiro, P; Yusuf, M; McAinsh, AD; Charras, G; Godinho, SA; (2016) DDR1 localisation to adherens junctions prevents efficient clustering of supernumerary centrosomes. In: (Proceedings) Annual Meeting of the American-Society-for-Cell-Biology (ASCB). AMER SOC CELL BIOLOGY

http://ift.tt/2hjOBhr

Homeostasis of the Cellular Actin Cortex

Fritzsche, M; Erlenkaemper, C; Charras, GT; Kruse, K; Eggeling, C; (2014) Homeostasis of the Cellular Actin Cortex. In: (Proceedings) 58th Annual Meeting of the Biophysical-Society. (pp. 735A-735A). CELL PRESS

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STRESS AT THE IMPLANT-BONE INTERFACE

WOLFE, LA; HOBKIRK, JA; (1984) STRESS AT THE IMPLANT-BONE INTERFACE. In: (pp. p. 506). AMER ASSOC DENTAL RESEARCH

http://ift.tt/2hhFWfg

THE USE OF MINIATURE SWINE IN DENTAL IMPLANT RESEARCH

HILL, TR; HOBKIRK, JA; (1984) THE USE OF MINIATURE SWINE IN DENTAL IMPLANT RESEARCH. In: (pp. p. 521). AMER ASSOC DENTAL RESEARCH

http://ift.tt/2zkK5WM

Laser und Narben

Zusammenfassung

Narben entstehen nach tiefdermalen Verletzungen der Haut und können sich in Abhängigkeit von Alter, Lokalisation, Ursache, Heilungsverlauf und individueller Disposition als unreife, reife, atrophe, hypertrophe oder keloidale Narben präsentieren. Vor allem Keloide und hypertrophe Narben sind häufig mit Juckreiz, Spannungsgefühl, Schmerzen und sogar Funktionseinschränkungen assoziiert und können die Lebensqualität von Patienten signifikant reduzieren. Auch vermeintlich physiologische Narbentypen, wie beispielsweise Ritznarben nach Selbstverletzungen, führen in vielen Fällen zu einem ausgeprägten Leidensdruck bei Betroffenen. Trotz intensiver Forschungsaktivität sind insbesondere die Pathomechanismen der überschießenden Narbenbildung bisher nur unzureichend verstanden und sicher wirksame Behandlungsmöglichkeiten bisher nicht verfügbar. Aufgrund zunehmend soliderer Studienlage werden heutzutage neben etablierten, konventionellen Verfahren vermehrt verschiedene Lasertechnologien und -wellenlängen zur Behandlung von verschiedenen Narbentypen eingesetzt.

http://ift.tt/2zr4Yz0

Health science education in primary schools: evaluation of procedures and results

Reiss, MJ; (2015) Health science education in primary schools: evaluation of procedures and results. In: Giuseppe, M, (ed.) Proceedings of the International Workshop on Health Science Education in Primary Schools 2015. Atti dei Convegni Lincei: Rome, Italy.

http://ift.tt/2iCp67E

Removal of divalent cations induces structural transitions in red clover necrotic mosaic virus, revealing a potential mechanism for RNA release.

Sherman, MB; Guenther, RH; Tama, F; Sit, TL; Brooks, CL; Mikhailov, AM; Orlova, EV; ... Lommel, SA; + view all Sherman, MB; Guenther, RH; Tama, F; Sit, TL; Brooks, CL; Mikhailov, AM; Orlova, EV; Baker, TS; Lommel, SA; - view fewer (2006) Removal of divalent cations induces structural transitions in red clover necrotic mosaic virus, revealing a potential mechanism for RNA release. J Virol , 80 (21) pp. 10395-10406. 10.1128/JVI.01137-06 .

http://ift.tt/2h9aD2t

DOSE-RELATED ENDOCRINE EFFECTS AND PHARMACOKINETICS OF ORAL AND INTRAMUSCULAR 4-HYDROXYANDROSTENEDIONE IN POSTMENOPAUSAL BREAST-CANCER PATIENTS

DOWSETT, M; CUNNINGHAM, DC; STEIN, RC; EVANS, S; DEHENNIN, L; HEDLEY, A; COOMBES, RC; (1989) DOSE-RELATED ENDOCRINE EFFECTS AND PHARMACOKINETICS OF ORAL AND INTRAMUSCULAR 4-HYDROXYANDROSTENEDIONE IN POSTMENOPAUSAL BREAST-CANCER PATIENTS. CANCER RESEARCH , 49 (5) pp. 1306-1312.

http://ift.tt/2iBBHYt

A RANDOMIZED PROSPECTIVE TRIAL OF SURGICAL AGAINST MEDICAL TETRACYCLINE PLEURODESIS IN THE MANAGEMENT OF MALIGNANT PLEURAL EFFUSIONS SECONDARY TO BREAST-CANCER

EVANS, TRJ; STEIN, RC; PEPPER, JR; GAZET, JC; FORD, HT; COOMBES, RC; (1993) A RANDOMIZED PROSPECTIVE TRIAL OF SURGICAL AGAINST MEDICAL TETRACYCLINE PLEURODESIS IN THE MANAGEMENT OF MALIGNANT PLEURAL EFFUSIONS SECONDARY TO BREAST-CANCER. EUROPEAN JOURNAL OF CANCER , 29A (3) pp. 316-319.

http://ift.tt/2haitJ9

Immunohistochemical studies of localization and co-localization of glutamate, aspartate and GABA in the anterior thalamic nuclei, retrosplenial granular cortex, thalamic reticular nucleus and mammillary nuclei of the rat.

Gonzalo-Ruiz, A; Sanz, JM; Lieberman, AR; (1996) Immunohistochemical studies of localization and co-localization of glutamate, aspartate and GABA in the anterior thalamic nuclei, retrosplenial granular cortex, thalamic reticular nucleus and mammillary nuclei of the rat. J Chem Neuroanat , 12 (2) pp. 77-84.

http://ift.tt/2iAvdsM

Local health and social care responses to implementing the national cold weather plan.

Heffernan, C; Jones, L; Ritchie, B; Erens, B; Chalabi, Z; Mays, N; (2017) Local health and social care responses to implementing the national cold weather plan. J Public Health (Oxf) pp. 1-6. 10.1093/pubmed/fdx120 .

http://ift.tt/2haEl7g

A systematic review and meta-analysis of tertiary interventions in clinical burnout

Perski, O; Grossi, G; Perski, A; Niemi, M; (2017) A systematic review and meta-analysis of tertiary interventions in clinical burnout. Scandinavian Journal of Psychology , 58 pp. 551-561. 10.1111/sjop.12398 .

http://ift.tt/2iCFDYT

Introduction to enzymes, receptors and the action of small molecule drugs

Roberts, SM; Gibb, AJ; (2013) Introduction to enzymes, receptors and the action of small molecule drugs.

http://ift.tt/2h9aADP

Boost resilience to tackle mental illness

Robinson, OJ; (2011) Boost resilience to tackle mental illness. NATURE , 478 (7370) p. 459.

http://ift.tt/2iBxWm2

Ranging behaviour of Marsh Harriers Circus aeruginosus in agricultural landscapes

Cardador, L; Manosa, S; Varea, A; Bertolero, A; (2009) Ranging behaviour of Marsh Harriers Circus aeruginosus in agricultural landscapes. IBIS , 151 (4) pp. 766-770.

http://ift.tt/2hahmJy

Adaptive regulation of riboflavin transport in heart: effect of dietary riboflavin deficiency in cardiovascular pathogenesis.

Udhayabanu, T; Karthi, S; Mahesh, A; Varalakshmi, P; Manole, A; Houlden, H; Ashokkumar, B; (2017) Adaptive regulation of riboflavin transport in heart: effect of dietary riboflavin deficiency in cardiovascular pathogenesis. Mol Cell Biochem 10.1007/s11010-017-3163-1 .

http://ift.tt/2iBxS5M

Brief Report: Drop in CD4+ Counts Below 200 Cells/μL After Reaching (or Starting From) Values Higher than 350 Cells/μL in HIV-Infected Patients With Virological Suppression.

Gianotti, N; Marchetti, G; Antinori, A; Saracino, A; Gori, A; Rizzardini, G; Lichtner, M; ... Cozzi-Lepri, A; + view all Gianotti, N; Marchetti, G; Antinori, A; Saracino, A; Gori, A; Rizzardini, G; Lichtner, M; Bandera, A; Mussini, C; Girardi, E; dʼArminio Monforte, A; Cozzi-Lepri, A; - view fewer (2017) Brief Report: Drop in CD4+ Counts Below 200 Cells/μL After Reaching (or Starting From) Values Higher than 350 Cells/μL in HIV-Infected Patients With Virological Suppression. J Acquir Immune Defic Syndr , 76 (4) pp. 417-422. 10.1097/QAI.0000000000001522 .

http://ift.tt/2hawjeJ

A broader vision for transport optimisation: towards an efficient and fair allocation of urban road space [Invited talk]

Anciaes, PR; (2017) A broader vision for transport optimisation: towards an efficient and fair allocation of urban road space [Invited talk]. Presented at: Design and optimization of transport systems in the context of urbanization, Shanghai, Shanghai, China. Green open access

http://ift.tt/2iC4jAX

Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination

Iacobaeus, E; Sugars, RV; Andren, AT; Alm, JJ; Qian, H; Frantzen, J; Newcombe, J; ... Le Blanc, K; + view all Iacobaeus, E; Sugars, RV; Andren, AT; Alm, JJ; Qian, H; Frantzen, J; Newcombe, J; Alkass, K; Druid, H; Bottai, M; Roytta, M; Le Blanc, K; - view fewer (2017) Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination. STEM CELLS TRANSLATIONAL MEDICINE , 6 (10) pp. 1840-1851. 10.1002/sctm.17-0028 .

http://ift.tt/2h9apZb

Relations of Demographic and Clinical Factors With Cardiovascular Autonomic Function in a Population-Based Study: An Assessment By Quantile Regression

Sluyter, JD; Hughes, AD; Camargo, CA; Lowe, A; Scragg, RKR; (2017) Relations of Demographic and Clinical Factors With Cardiovascular Autonomic Function in a Population-Based Study: An Assessment By Quantile Regression. American Journal of Hypertension 10.1093/ajh/hpx134 .

http://ift.tt/2iCJPrZ

Exhibition of doctors' photographs - Five female doctors should have been named in article

Dezateux, C; (1997) Exhibition of doctors' photographs - Five female doctors should have been named in article. BRITISH MEDICAL JOURNAL , 314 (7088) p. 1199.

http://ift.tt/2haisVB

FROM SURVEILLANCE TO POLICY: SCREENING FOR MEDIUM CHAIN ACYL COA DEHYDROGENASE DEFICIENCY

Dezateux, C; (2010) FROM SURVEILLANCE TO POLICY: SCREENING FOR MEDIUM CHAIN ACYL COA DEHYDROGENASE DEFICIENCY. In: (pp. p. 10). WILEY-BLACKWELL PUBLISHING, INC

http://ift.tt/2iC4bBt

The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes

Cordeiro, CD; Saiardi, A; Docampo, R; (2017) The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. MOLECULAR MICROBIOLOGY , 106 (2) pp. 319-333. 10.1111/mmi.13766 .

http://ift.tt/2h9af41

Effect of monthly, high-dose, long-term vitamin D supplementation on central blood pressure parameters: A randomized controlled trial substudy

Sluyter, JD; Camargo, CA; Stewart, AW; Waayer, D; Lawes, CMM; Toop, L; Khaw, KT; ... Scragg, R; + view all Sluyter, JD; Camargo, CA; Stewart, AW; Waayer, D; Lawes, CMM; Toop, L; Khaw, KT; Thom, SAMG; Hametner, B; Wassertheurer, S; Parker, KH; Hughes, AD; Scragg, R; - view fewer (2017) Effect of monthly, high-dose, long-term vitamin D supplementation on central blood pressure parameters: A randomized controlled trial substudy. Journal of the American Heart Association , 6 (10) 10.1161/JAHA.117.006802 . Green open access

http://ift.tt/2iAvbRG

Affective Inheritances: A Review Essay

Dawson, L; Langley, E; (2017) Affective Inheritances: A Review Essay. [Review]. Early Theatre , 20 (1) pp. 133-152. 10.12745/et.20.1.3160 . Green open access

http://ift.tt/2hcvX7v

A Study of Clinical Significance of the Depth of Olfactory Fossa in Patients Undergoing Endoscopic Sinus Surgery

Abstract

The endoscope has revolutionized the diagnosis and treatment of diseases of the nose and paranasal sinuses. Endoscopic sinus surgery (ESS), like all minimally invasive surgery, is designed to combine an excellent outcome with minimal patient discomfort. Successful outcome with minimal complications can only be achieved with good knowledge of the endoscopic anatomy, appropriate training in the procedure and the understanding of the anatomical variations. The intraoperative complications of ESS are bleeding and injury to surrounding structures commonly the orbital structures and fovea ethmoidalis. This is a hospital based prospective observational study with an objective to define the distribution of Keros classification of the depth of olfactory fossa and its asymmetrical distribution rates based on Keros type. Prospective study in a tertiary rural based hospital. 100 patients above the age of 10 years from October 2013 to March 2015 for a period of one year six months undergoing endoscopic sinus surgery in the Department of ENT, P.E.S. Institute of Medical Sciences and Research, Kuppam were chosen randomly. The data was collected from these patients who will met the inclusion criteria of the study and before undergoing endoscopic sinus surgery by subjecting them to CT scan of paranasal sinuses. It is observed that a total of 100 patients had been studied in which the mean age of the population is 36.65 + 13.36 years. Youngest patient was 12 years old and eldest patient was 70 years old. Among the patients 50(50%) were males and remaining 50(50%) were females with a female to male ratio is 1:1. In the present study, the depth of olfactory fossa ranged from 2.1 to 8.3 mm inclusive of both sides in 200 CT images with a mean height of 5.21 mm. Of the 200 sides measured, the distribution of Keros classification is as the following—Keros type I 39(19.5%), Keros type II 143(71.5%) and Keros type III 18(9%) sides. Based on these observations, type II is the most common Keros type prevalent followed by type 1 Keros type and the least prevalent is the type III Keros type in the studied population. In the present study, on considering sides separately, the right side olfactory fossa depth ranged from 2.1 to 8.3 mm with a mean height of 5.43 mm and the left side olfactory fossa depth ranged from 2.1 to 8.1 mm with a mean height of 4.98 mm. On the right side, of 100 sides measured, the distribution of Keros classification is as the following—Keros type I 19(19%), Keros type II 68(68%) and Keros type III 13(13%) sides. On the left side, of 100 sides measured, the distribution of Keros classification is as the following—Keros type I 25(25%), Keros type II 70(70%) and Keros type III 5(5%) sides. Based on these observations, type II is the most common Keros type prevalent followed by type 1 Keros type and the least prevalent is the type III Keros type in the studied population on both sides. In the present study, out of 100 patients 23 patients were having asymmetric olfactory fossa between right and left sides based on Keros type, where as remaining 77% had symmetric Keros type on right and left sides. Out of 23 patients, 16 patients were having lower or deep olfactory fossa on right side, where as remaining 7 patients were having lower or deep olfactory fossa on left side. Based on these observations, a lower or deep ethmoid roof occurred more frequently on the right side than on the left side. Wilcoxon matched pair signed rank test is applied to see the significant difference between depth of right and left olfactory fossae. Since P value is < 0.001 the depth of olfactory fossa is significantly different from each other. The present study presents a precise, quantitative analysis of the olfactory fossa and ethmoid roof position as well as individual asymmetry. This information may be useful during pre-operative evaluation of CT images, as well as intraoperatively. The surgeon's understanding of the anatomy of a patient's ethmoid roof and its possible variations is crucial for countering possible complication risks during endoscopic sinus surgery.

http://ift.tt/2lYvyKV

A Study of Clinical Significance of the Depth of Olfactory Fossa in Patients Undergoing Endoscopic Sinus Surgery

Abstract

The endoscope has revolutionized the diagnosis and treatment of diseases of the nose and paranasal sinuses. Endoscopic sinus surgery (ESS), like all minimally invasive surgery, is designed to combine an excellent outcome with minimal patient discomfort. Successful outcome with minimal complications can only be achieved with good knowledge of the endoscopic anatomy, appropriate training in the procedure and the understanding of the anatomical variations. The intraoperative complications of ESS are bleeding and injury to surrounding structures commonly the orbital structures and fovea ethmoidalis. This is a hospital based prospective observational study with an objective to define the distribution of Keros classification of the depth of olfactory fossa and its asymmetrical distribution rates based on Keros type. Prospective study in a tertiary rural based hospital. 100 patients above the age of 10 years from October 2013 to March 2015 for a period of one year six months undergoing endoscopic sinus surgery in the Department of ENT, P.E.S. Institute of Medical Sciences and Research, Kuppam were chosen randomly. The data was collected from these patients who will met the inclusion criteria of the study and before undergoing endoscopic sinus surgery by subjecting them to CT scan of paranasal sinuses. It is observed that a total of 100 patients had been studied in which the mean age of the population is 36.65 + 13.36 years. Youngest patient was 12 years old and eldest patient was 70 years old. Among the patients 50(50%) were males and remaining 50(50%) were females with a female to male ratio is 1:1. In the present study, the depth of olfactory fossa ranged from 2.1 to 8.3 mm inclusive of both sides in 200 CT images with a mean height of 5.21 mm. Of the 200 sides measured, the distribution of Keros classification is as the following—Keros type I 39(19.5%), Keros type II 143(71.5%) and Keros type III 18(9%) sides. Based on these observations, type II is the most common Keros type prevalent followed by type 1 Keros type and the least prevalent is the type III Keros type in the studied population. In the present study, on considering sides separately, the right side olfactory fossa depth ranged from 2.1 to 8.3 mm with a mean height of 5.43 mm and the left side olfactory fossa depth ranged from 2.1 to 8.1 mm with a mean height of 4.98 mm. On the right side, of 100 sides measured, the distribution of Keros classification is as the following—Keros type I 19(19%), Keros type II 68(68%) and Keros type III 13(13%) sides. On the left side, of 100 sides measured, the distribution of Keros classification is as the following—Keros type I 25(25%), Keros type II 70(70%) and Keros type III 5(5%) sides. Based on these observations, type II is the most common Keros type prevalent followed by type 1 Keros type and the least prevalent is the type III Keros type in the studied population on both sides. In the present study, out of 100 patients 23 patients were having asymmetric olfactory fossa between right and left sides based on Keros type, where as remaining 77% had symmetric Keros type on right and left sides. Out of 23 patients, 16 patients were having lower or deep olfactory fossa on right side, where as remaining 7 patients were having lower or deep olfactory fossa on left side. Based on these observations, a lower or deep ethmoid roof occurred more frequently on the right side than on the left side. Wilcoxon matched pair signed rank test is applied to see the significant difference between depth of right and left olfactory fossae. Since P value is < 0.001 the depth of olfactory fossa is significantly different from each other. The present study presents a precise, quantitative analysis of the olfactory fossa and ethmoid roof position as well as individual asymmetry. This information may be useful during pre-operative evaluation of CT images, as well as intraoperatively. The surgeon's understanding of the anatomy of a patient's ethmoid roof and its possible variations is crucial for countering possible complication risks during endoscopic sinus surgery.

http://ift.tt/2lYvyKV

Autoimmune chronic spontaneous urticaria

Publication date: Available online 6 November 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Clive Grattan




http://ift.tt/2zk6SC4

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease

Publication date: Available online 6 November 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Marcin G. Fraczek, Livingstone Chishimba, Rob M. Niven, Mike Bromley, Angela Simpson, Lucy Smyth, David W. Denning, Paul Bowyer
BackgroundAllergic diseases caused by fungi are common. The best understood conditions are allergic bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS). Our knowledge of the fungal microbiome (mycobiome) is limited to a few studies involving healthy individuals, asthmatics and smokers. No study has yet examined the mycobiome in fungal lung disease.ObjectivesThe main aim of this study was to determine the mycobiome in lungs of individuals with well characterised fungal disease. A secondary objective was to determine possible effects of treatment on the mycobiome.MethodsAfter bronchoscopy, ITS1 DNA was amplified and sequenced and fungal load determined by RT-PCR. Clinical and treatment variables were correlated with the main species identified. ABPA (n=16), SAFS (n=16), severe asthma not sensitised to fungi, (n=9), mild asthma patients(n=7) and 10 healthy controls were studied.ResultsThe mycobiome was highly varied with severe asthmatics carrying higher loads of fungus. Healthy individuals had low fungal loads, mostly poorly characterised Malasezziales.The most common fungus in asthmatics was Aspergillus fumigatus complex and this taxon accounted for the increased burden of fungus in the high level samples. Corticosteroid treatment was significantly associated with increased fungal load (p<0.01).ConclusionsThe mycobiome is highly variable. Highest loads of fungus are observed in severe asthmatics and the most common fungus is Aspergillusfumigatus complex. Individuals receiving steroid therapy had significantly higher levels of Aspergillus and total fungus in their BAL.

Teaser

This article reports the first analysis of fungal communities in lungs of individuals with fungal disease. Effects of steroid and antifungal drugs suggest complex patterns of fungal burden with potential implications for treatment.


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Reply

Publication date: Available online 6 November 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Pavel Kolkhir, Martin K. Church, Karsten Weller, Martin Metz, Oliver Schmetzer, Marcus Maurer




http://ift.tt/2zjKx7N

Cholesterol-α-glucosyltransferase gene is present in most Helicobacter species including gastric non-Helicobacter pylori helicobacters obtained from Japanese patients

Abstract

Background

Non-Helicobacter pylori helicobacters (NHPHs) besides H. pylori infect human stomachs and cause chronic gastritis and mucosa-associated lymphoid tissue lymphoma. Cholesteryl-α-glucosides have been identified as unique glycolipids present in H. pylori and some Helicobacter species. Cholesterol-α-glucosyltransferase (αCgT), a key enzyme for the biosynthesis of cholesteryl-α-glucosides, plays crucial roles in the pathogenicity of H. pylori. Therefore, it is important to examine αCgTs of NHPHs.

Materials and Methods

Six gastric NHPHs were isolated from Japanese patients and maintained in mouse stomachs. The αCgT genes were amplified by PCR and inverse PCR. We retrieved the αCgT genes of other Helicobacter species by BLAST searches in GenBank.

Results

αCgT genes were present in most Helicobacter species and in all Japanese isolates examined. However, we could find no candidate gene for αCgT in the whole genome of Helicobacter cinaedi and several enterohepatic species. Phylogenic analysis demonstrated that the αCgT genes of all Japanese isolates show high similarities to that of a zoonotic group of gastric NHPHs including Helicobacter suis, Helicobacter heilmannii, and Helicobacter ailurogastricus. Of 6 Japanese isolates, the αCgT genes of 4 isolates were identical to that of H. suis, and that of another 2 isolates were similar to that of H. heilmannii and H. ailurogastricus.

Conclusions

All gastric NHPHs examined showed presence of αCgT genes, indicating that αCgT may be beneficial for these helicobacters to infect human and possibly animal stomachs. Our study indicated that NHPHs could be classified into 2 groups, NHPHs with αCgT genes and NHPHs without αCgT genes.

http://ift.tt/2lZgs88

A case of Mirizzi syndrome that was successfully treated by laparoscopic choledochoplasty using a gallbladder patch

Abstract

The use of laparoscopic surgery in the treatment of Mirizzi syndrome is considered controversial due to the degree of technical difficulty. We herein describe the case of a 36-year-old woman who was admitted to our hospital due to appetite loss, nausea and back pain. Endoscopic retrograde cholangiography revealed a round-shaped filling defect at the confluence of the bile duct. The patient was diagnosed with Mirizzi syndrome Type II according to the Csendes classification. Before surgery, an endoscopic nasobiliary drainage tube was placed for intraoperative cholangiography. Based on the intraoperative findings, the anterior wall of Hartmann's pouch was excised to remove the impacted gallstone. The neck portion of the gallbladder wall was then used to make a gallbladder patch, which was sutured to cover the anterior wall of the common hepatic bile duct. Laparoscopic choledochoplasty using a gallbladder patch was a technically feasible treatment for Mirizzi syndrome Type II.

http://ift.tt/2zmpX3X

Elasto fibroma Dorsi: a case report of bilateral tumours and excision of the symptomatic lesion in a male patient

Abstract

Elasto fibroma dorsi is a rare tumour of the shoulder girdle that usually arises at the infra scapular area. We present a 57-year-old male with a soft tissue swelling on his right infra scapular area of 6 months duration. It was a painless lesion which caused him discomfort while sleeping. Preoperative imaging revealed bilateral tumours but the left tumour was impalpable. The surgery itself was uneventful but post-operatively he developed a haematoma which was managed conservatively Elasto fibroma is a benign pseudo tumour of the shoulder girdle. It's aetiology is tied in to repetitive trauma of the shoulder girdle resulting in a pseudo tumour at the infra scapular area. Magnetic resonance imaging is the diagnostic modality of choice and is pathognomic in the presence of bilateral infra scapular tumours. Treatment is usually conservative and tissue diagnosis is essential as it can mimic a soft tissue sarcoma radiologically.

http://ift.tt/2ycdtuy

Giant splenic hemangioma in a 10-year-old boy treated with a spleen saving surgery

Abstract

Tumors of spleen are rare. The most common benign tumor of spleen is hemangioma. Most splenic hemangiomas (SH) tend to be discovered in mid-30s to mid-50s. SH are discovered incidentally in most of the cases as they are usually asymptomatic. Small asymptomatic SH can be managed with observation. The treatment options for large hemangiomas are embolization of the splenic arterial branch, splenectomy by laparotomy or laparoscopy. Partial splenectomy can be done if the lesion is small and located at the poles of the spleen. We present a rare case of splenic hemangioma in a 10-year-old boy who presented with a painless palpable mass in the left upper abdomen. On CT scan—A large well-defined cystic lesion with few thin enhancing septa within it is seen involving the spleen. Laparotomy was done followed by Partial splenectomy. The histopathology report was suggestive of Cavernous Hemangioma of spleen.

http://ift.tt/2zookDd

Neonatal screening for inborn errors of metabolism.

Cunningham, G; Green, NS; (2005) Neonatal screening for inborn errors of metabolism. Lancet , 365 (9478) pp. 2175-2176. 10.1016/S0140-6736(05)66770-0 .

http://ift.tt/2yc1s8o

Managing yourself: Could your personality derail your career?: Don’t take these traits to the extreme

Chamorro-Premuzic, T; (2017) Managing yourself: Could your personality derail your career?: Don't take these traits to the extreme. Harvard Business Review , 2017 (Septembe)

http://ift.tt/2zmHgly

Modeling of liquid crystal structures

Day, SE; Nie, Z; Yang, M; Fernandez, FA; (2015) Modeling of liquid crystal structures. In: (pp. 13-).

http://ift.tt/2yakdZR

Engagement in an e-health tool (ORION) predicts opioid-dependent patient likelihood of behavioural change

Humphris, G; Carrà, G; Frisher, M; Neufeind, J; Cecil, J; Scherbaum, N; Crome, I; Humphris, G; Carrà, G; Frisher, M; Neufeind, J; Cecil, J; Scherbaum, N; Crome, I; Baldacchino, A; - view fewer (2017) Engagement in an e-health tool (ORION) predicts opioid-dependent patient likelihood of behavioural change. Heroin Addiction and Related Clinical Problems , 19 (5) pp. 35-44.

http://ift.tt/2znD9pe

Mentalising music in frontotemporal dementia

Downey, LE; Blezat, A; Golden, HL; Nicholas, J; Mahoney, CJ; Omar, R; Crutch, SJ; Downey, LE; Blezat, A; Golden, HL; Nicholas, J; Mahoney, CJ; Omar, R; Crutch, SJ; Warren, JD; - view fewer (2012) Mentalising music in frontotemporal dementia. In: (Proceedings) 8th International Conference on Frontotemporal Dementias. (pp. p. 190). KARGER

http://ift.tt/2ycLjzK

The potential of the multivariate multilevel model for analysing correlated multiple outcomes: a simulation study

Vickerstaff, V; Ambler, G; Omar, RZ; (2015) The potential of the multivariate multilevel model for analysing correlated multiple outcomes: a simulation study. In: BIOMED CENTRAL LTD

http://ift.tt/2zoMwW2

Proposals for mental disorders specifically associated with stress in the International Classification of Diseases-11 (vol 381, pg 1683, 2013)

Maercker, A; Brewin, CR; Bryant, RA; (2013) Proposals for mental disorders specifically associated with stress in the International Classification of Diseases-11 (vol 381, pg 1683, 2013). LANCET , 381 (9878) p. 1626.

http://ift.tt/2ycLdYU

Erratum to: How effective are plant macrofossils as a proxy for macrophyte presence? The case of Najas flexilis in Scotland

Bishop, IJ; Bennion, H; Patmore, IR; Sayer, CD; (2017) Erratum to: How effective are plant macrofossils as a proxy for macrophyte presence? The case of Najas flexilis in Scotland. Journal of Paleolimnology pp. 1-2. 10.1007/s10933-017-9992-9 . (In press).

http://ift.tt/2zo1lYR

Virology in a “post-truth” world

Griffiths, PD; (2017) Virology in a "post-truth" world. Reviews in Medical Virology , 27 (3) 10.1002/rmv.1928 .

http://ift.tt/2ycL9bC

In vivo function of D2 dopaminergic receptors.

Samad, TA; Baik, JH; Picetti, R; Saiardi, A; Thiriet, G; Borrelli, E; (1996) In vivo function of D2 dopaminergic receptors. M S-MEDECINE SCIENCES , 12 (3) pp. 377-379.

http://ift.tt/2zoMihE

Hypoxia-Mimicking Bioactive Glass/Collagen Glycosaminoglycan Composite Scaffolds to Enhance Angiogenesis and Bone Repair

Quinlan, E; Partap, S; Azevedo, MM; Jell, G; Stevens, M; O'Brien, FJ; (2015) Hypoxia-Mimicking Bioactive Glass/Collagen Glycosaminoglycan Composite Scaffolds to Enhance Angiogenesis and Bone Repair. In: (Proceedings) 4th TERMIS World Congress. (pp. S107-S108). MARY ANN LIEBERT, INC

http://ift.tt/2yaxsd3

Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae (vol 468, pg 28, 2000)

Saiardi, A; Caffrey, JJ; Snyder, SH; Shears, SB; (2000) Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae (vol 468, pg 28, 2000). FEBS LETTERS , 469 (2-3) p. 213.

http://ift.tt/2zoMc9M

A Novel Role for Polyphosphate in Astrocyte Signalling

Holmstrom, KM; Gourine, AV; Abramov, AY; (2011) A Novel Role for Polyphosphate in Astrocyte Signalling. In: (Proceedings) 55th Annual Meeting of the Biophysical-Society. (pp. p. 562). CELL PRESS

http://ift.tt/2y9OGqR

SEIZURE ACTIVITY GENERATES CALCIUM-INDEPENDENT REACTIVE OXYGEN SPECIES VIA NADPH OXIDASE AND XANTHINE OXIDASE

Kovac, S; Hamil, N; Williams, S; Domijan, A; Walker, MC; Abramov, AY; (2012) SEIZURE ACTIVITY GENERATES CALCIUM-INDEPENDENT REACTIVE OXYGEN SPECIES VIA NADPH OXIDASE AND XANTHINE OXIDASE. In: (Proceedings) 10th European Congress on Epileptology. (pp. p. 178). WILEY-BLACKWELL

http://ift.tt/2zoM5Lo

A missense mutation in the KCTD17 gene causes autosomal dominant myoclonus-dystonia

Mencacci, NE; Rubio-Augusti, I; Zdebik, A; Asmus, F; Ludtmann, M; Hauser, AK; Plagnol, V; ... Wood, NW; + view all Mencacci, NE; Rubio-Augusti, I; Zdebik, A; Asmus, F; Ludtmann, M; Hauser, AK; Plagnol, V; Pittman, A; Bandres-Ciga, S; Soutar, M; Peall, K; Morris, H; Trabzuni, D; Ryten, M; Tekman, M; Stanescu, H; Kleta, R; Carecchio, M; Nardocci, N; Garavaglia, B; Lohmann, E; Weissbach, A; Klein, C; Hardy, J; Abramov, AY; Foltynie, T; Gasser, T; Bhatia, KP; Wood, NW; - view fewer (2015) A missense mutation in the KCTD17 gene causes autosomal dominant myoclonus-dystonia. In: (Proceedings) 19th International Congress of Parkinson's Disease and Movement Disorders. (pp. S457-S458). WILEY-BLACKWELL

http://ift.tt/2yd2wsI

Multi-disciplinary low vision services in the United Kingdom

Ryan, B; Culham, LE; Hill, AR; Jackson, AJ; Jones, B; Bird, AC; Bunce, C; (1999) Multi-disciplinary low vision services in the United Kingdom. Visual Impairment Research , 1 (3) pp. 181-186. 10.1076/vimr.1.3.181.4445 .

http://ift.tt/2zmH59S

Topical treatments for vernal keratoconjunctivitis

Flynn, T; Dahlmann-Noor, A; Bunce, C; Tuft, S; (2017) Topical treatments for vernal keratoconjunctivitis. Cochrane Database of Systematic Reviews , 2017 (8) 10.1002/14651858.CD010466.pub2 .

http://ift.tt/2ycIGhn

Human-environment interactions through the epipalaeolithic of eastern Jordan

Jones, MD; Maher, LA; Richter, T; Macdonald, D; Martin, L; (2016) Human-environment interactions through the epipalaeolithic of eastern Jordan. In: The Archaeology of Human-Environment Interactions: Strategies for Investigating Anthropogenic Landscapes, Dynamic Environments, and Climate Change in the Human Past. (pp. 121-140).

http://ift.tt/2zoLSb4

Discovery of Middle Pleistocene fossil and stone tool-bearing deposits at Groot Kloof, Northern Cape Province, South Africa

Curnoe, D; Herries, A; Brink, J; Hopley, P; Henderson, Z; Van Reyneveld, K; (2006) Discovery of Middle Pleistocene fossil and stone tool-bearing deposits at Groot Kloof, Northern Cape Province, South Africa. In: (pp. p. 223). ELSEVIER GMBH, URBAN & FISCHER VERLAG

http://ift.tt/2y9OqIp

Automatic approach bias towards smoking cues is present in smokers but not in ex-smokers

Wiers, CE; Kühn, S; Javadi, AH; Korucuoglu, O; Wiers, RW; Walter, H; Gallinat, J; Wiers, CE; Kühn, S; Javadi, AH; Korucuoglu, O; Wiers, RW; Walter, H; Gallinat, J; Bermpohl, F; - view fewer (2013) Automatic approach bias towards smoking cues is present in smokers but not in ex-smokers. Psychopharmacology , 229 (1) pp. 187-197. 10.1007/s00213-013-3098-5 .

http://ift.tt/2znD98I