Medicine by Sfakianakis Alexandros: 09/27/18

Renal cell carcinoma (RCC) metastatic in the sinonasal cavity is rare. In many cases, it represents the initial presentation of RCC. We conducted a retrospective chart review to report the clinical presentation, imaging, and treatment of RCC metastases in the sinonasal cavity at two tertiary care referral centers. Our population was made up of 8 patients-6 men and 2 women, aged 55 to 86 years (mean: 66.9; median: 63.5)-who had been diagnosed with cancer in the sinonasal cavity. The most common complaints were epistaxis, nasal obstruction, and diplopia. Cancers were located in the ethmoid sinus (n = 3), nasal cavity (n = 2), sphenoid sinus (n = 2), and maxillary sinus (n = 1). Local treatment involved resection and adjuvant radiotherapy in 4 patients, surgery alone in 2 patients, and radiotherapy alone in the other 2. The lesion was embolized before surgery in 4 cases. We also performed a critical review of similar published cases. Our literature review covered 53 cases of RCC metastatic to the sinonasal cavity, including ours. Metastases were the first presentation of RCC in 24 of these cases (45.3%); in our series, the metastases led to the diagnosis of the primary RCC in 3 cases (37.5%). In the 53 reported cases, metastatic resection was performed on 35 patients (66.0%). Survival data were available for 22 of these operated patients, and 17 of them achieved a complete local response. Adjunctive radiotherapy was not associated with a better local response. Overall survival was significantly better in patients who had an isolated metastasis rather than multiple metastases (p = 0.013). There was no difference in overall survival between patients whose metastasis represented the initial presentation of RCC and those whose metastasis did not (p = 0.95). We recommend that sinonasal metastasis be suspected in the event of unilateral nasal bleeding or nasal obstruction in patients diagnosed with RCC. Embolization may prevent abundant bleeding during removal. Surgery may improve the quality of life of these patients while decreasing nasal obstruction and bleeding.

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Positivity rates of in vitro inhalant/respiratory and food allergy tests in the northern midwestern United States

Michael S. Benninger, MD; Thomas Daly, MD; Kevin Graffmiller, MD

Abstract

Rates of allergy-test positivity vary by country and by regions within countries. Several studies have looked at allergy test results to determine the most common allergens. Many of these studies have been based on surveys or on studies of small numbers of tests. Positivity rates for allergy tests are poorly defined in the northern midwestern region of the United States. We conducted a study to identify the rates of positive allergy tests for both inhalant/respiratory allergens and food allergens in the upper Midwest. We extracted from our laboratory database the results of all test samples sent for one of eight allergen panels that had been analyzed between Sept. 1, 2014, and Sept. 1, 2015. All testing was performed at The Cleveland Clinic with the Phadia ImmunoCAP system. The percentage of positive tests, the distribution of the most frequently positive tests, and the class of in vitro responses were identified. A total of 148,628 test results for 63 different allergens were identified. Of the 125,190 tests for inhalant/respiratory allergens, the most frequently positive were dog dander (24% of tests), cat dander (23%), dust mites (23% for both Dermatophagoides pteronyssinus and Dermatophagoides farinae), and June grass (21%). Of the 23,438 food tests, the most frequently positive test results were for milk (18%), peanut (17%), wheat (16%), and egg white (15%). Most of the results fell into classes 1 through 3, although there was still a notable number of very high responses (class 5 and 6). These findings suggest that there is wide variability in the positivity of in vitro allergy tests and that the likelihood of a positive result in screening panels can be estimated. Evaluating such rates will help identify the most and least common allergens and will help to cost-effectively refine allergy screening panels.

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Audiologic profile in patients with ankylosing spondylitis: A controlled study of 30 patients

Lumy Yagueshita, MD; Lucas Resende Lucinda, MD; Valderilio Azevedo, PhD; Gislaine Richter Minhoto Wiemes, PhD; Nicole Richter Minhoto Wiemes, MD; Jose Fernando Polanski, PhD

Abstract

Recent studies have identified sensorineural hearing loss as a possible manifestation of ankylosing spondylitis. We conducted a study of 30 patients with ankylosing spondylitis to characterize their audiologic profile and to correlate their disease activity and functional indices with their hearing thresholds. The study group was made up of 18 men and 12 women, aged 25 to 58 years (mean: 46.5), who were diagnosed with ankylosing spondylitis. We compared their findings with a socially and demographically matched group of 30 healthy controls. All 60 participants underwent an audiologic assessment, consisting of pure-tone audiometry, speech audiometry, and tympanometry. We used validated indices to assess disease activity and functional status, and we compiled information on the time of diagnosis and the types of medications used to treat the ankylosing spondylitis. We found that the average of the mean air-conduction thresholds at 0.5, 1, 2, and 4 kHz in the ankylosing spondylitis group was significantly worse than that of the controls (p = 0.004). A statistically significant difference was observed at frequencies greater than 3 kHz (p < 0.05). A subgroup of case patients who used only a tumor necrosis factor-alpha inhibitor exhibited better hearing thresholds than patients who used other drugs (p = 0.01). Differences in functional and disease activity scores between case patients with and without hearing loss were not statistically significant. We found that patients with ankylosing spondylitis did indeed have a greater prevalence of sensorineural hearing loss but that it was not correlated with either disease activity or functional status.

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Button battery insertion in nose manifested as infraorbital cellulitis

Sheng-Yao Cheng, MD; Cheng-Ping Shih, MD

Infraorbital cellulitis developing from a nasal foreign body is relatively rare and should be considered when diagnosing a child with a presentation similar to the one described in this article.

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Histoplasmosis of the head and neck in the immunocompetent patient: Report of 2 cases

Ashley P. O'Connell Ferster, MD; Aaron Jaworek, MD; Amanda Hu, MD, FRCSC

Abstract

Histoplasmosis of the head and neck is rarely seen in immunocompetent patients. We report 2 new cases of histoplasmosis of the head and neck in immunocompetent patients, one an 80-year-old man and the other a 57-year-old man. The older man presented with oral cavity histoplasmosis; his symptoms included pain, dysphagia, and ulcerative lesions. The younger man had laryngeal histoplasmosis, which resulted in hoarseness and dyspnea. We discuss the methods of diagnosis and the classic findings in histoplasmosis, including the microscopic appearance of caseating granulomas, the results of periodic acid-Schiff staining and Gomori staining, and antibody detection of histoplasmosis. We also review the treatment options with antifungals, including amphotericin B and the oral conazole drugs. With an accurate diagnosis and proper treatment, both of our patients recovered well and their symptoms resolved. Because their symptoms overlapped with those of other, more common disease processes, an accurate diagnosis of these patients was essential to treating their infection.

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Primary pleomorphic adenoma of the middle ear and mastoid

Asnake Bitew, MD; Tsion Sahle, MD; Miriam Redleaf, MD FACS

Unlike metastatic cases, primary pleomorphic adenomas tend to recur and tend to be aggressive.

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Nonarytenoid laryngeal granulomas

Marissa Evarts, DO; Jonathan Romak, MD; Robert T. Sataloff, MD, DMA, FACS

Contact and postintubation granulomas rarely are located on the middle third or anterior portion of the vocal folds, with few reported in the literature.

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Nondisseminated rhinosporidiosis with multisite involvement in the head and neck

K Devaraja, MS; Prem Sagar, MS; Chirom Amit Singh, MS; Rajeev Kumar, MS

Abstract

Rhinosporidiosis is a communicable disease prevalent in tropical countries that affects one or more mucocutaneous sites such as the nasal cavity, pharynx, skin, bronchus, genitals, and bone, in isolation or together. We report a case of multicentric rhinosporidiosis involving the nasal cavity, oropharynx, larynx, and cheek skin without disseminated disease outside the head and neck. Although the appearance of mucocutaneous lesions in our patient was similar to that of papilloma or neoplasm, the distinct clinicopathologic characteristics of the rhinosporidiosis guided us in managing the case successfully. In our own experience with 11 patients with rhinosporidiosis on whom we operated over the past 5 years, the nasal cavity and pharynx were the most commonly involved sites in the head and neck. Surgical excision of all lesions along with cauterization of the base and long-term dapsone therapy is the current standard of care for multicentric rhinosporidiosis.

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Endoscopic view of the carotid artery in the sphenoid sinus

Eiji Yanagisawa, MD, FACS; Dewey A. Christmas, MD; Joseph P. Mirante, MD, MBA, FACS

The sphenoid sinus has been described as the most variable, in shape and size, of any bilateral cavity or organ in the human body.

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Mucocele development after endoscopic sinus surgery for nasal polyposis: A long-term analysis

Hakim Benkhatar, MD; Idir Khettab, MD; Philippe Sultanik, MD, PhD; Ollivier Laccourreye, MD; Pierre Bonfils, MD, PhD

Abstract

The aim of the present study was to determine the prevalence of long-term mucocele development after functional endoscopic sinus surgery (FESS) for nasal polyposis, to search for a statistical relationship with preoperative variables and to analyze the management of this complication. A retrospective analysis of 153 patients who underwent FESS for nasal polyposis, with a minimum of 7 years of follow-up, was performed. Mucocele diagnosis was based on regular clinical and radiologic evaluation. Univariate and multivariate statistical analysis was performed. The postoperative mucocele rate was 13.1% (20 patients). The mean delay between surgery and mucocele diagnosis was 6.25 years. A high preoperative Lund-Mackay score (>19) was a risk factor for postoperative mucocele (p = 0.04). Asthma and aspirin intolerance did not increase the risk of this complication. Endoscopic marsupialization of mucoceles was successful in 19 patients, with only one recurrent frontal mucocele. One patient required external approaches for two frontal mucoceles. In conclusion, mucocele risk after FESS for nasal polyposis is significant, especially in case of a high preoperative Lund-Mackay score (>19). Long-term clinical follow-up is recommended, imaging being prescribed based on symptoms or abnormal findings on clinical examination. Endoscopic marsupialization is very effective, but frontal mucoceles are more likely to recur.

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Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a median just noticeable difference of 438 μs. Out of the four listeners who were not sensitive to ITD, one listener reported binaural fusion, and three listeners reported no binaural fusion. To enable ITD sensitivity, a frequency-dependent delay of the electrical stimulus was required to synchronize the electric and acoustic signals at the level of the auditory nerve. Using subjective fusion measures and refined by ITD sensitivity, it was possible to match a CI electrode to an acoustic frequency range. This shows the feasibility of these measures for the allocation of acoustic frequency ranges to electrodes when fitting a CI to a subject with (near) normal hearing in the contralateral ear.

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Dr. J. Caleb Simmons Discusses a New Treatment for Obstructive Sleep Apnea

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Risk Factors Associated With Unplanned Reoperation in Major Head and Neck Surgery

This cohort study uses the American College of Surgeons National Surgical Quality Improvement Program 2005-2014 database to identify risk factors associated with unplanned reoperation following major head and neck surgical procedures.

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Rapidly Enlarging Parapharyngeal Mass

A man in his 40s with Poland syndrome presented with 6-month history of left throat pain and enlarging oropharyngeal mass. What is your diagnosis?

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Patient Concerns About Nasal Reconstruction and Implications for Shared Decision Making

This study examines the concerns of patients with nonmelanoma skin cancer regarding nasal reconstruction after Mohs surgery to develop an intervention to improve the shared decision-making process of patients and practitioners.

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Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss

This systematic review and meta-analysis of 19 studies evaluates the benefit of the addition of hyperbaric oxygen therapy for patients with sudden sensorineural hearing loss.

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Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating

This case series assessed individual test-retest reliability of the 2-alternative forced-choice and tinnitus likeness rating approaches in patients undergoing evaluation for tinnitus.

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Suppressed descending pain modulatory and enhanced sensorimotor networks in patients with chronic low back pain

Abstract

Purpose

Although cerebral structural and functional changes were uncovered by neuroimaging in patients with chronic low back pain (CLBP), their associations remain to be clarified. We co-analyzed anatomical and functional magnetic resonance imaging data in those patients and tested whether cortical gray matter volume changes are associated with altered pain modulatory networks underlying chronification of pain.

Methods

In 16 patients with CLBP and 16 heathy controls, we performed functional magnetic resonance imaging during mechanical pain stimulation on the lower back followed by anatomical imaging. We performed voxel-based morphometry and functional connectivity analysis from the seeds with altered gray matter volume, and examined correlations between imaging and psychophysical parameters.

Results

Patients showed decreases in gray matter volume at the right dorsolateral prefrontal cortex, middle occipital gyrus, and cerebellum, and showed increases at the bilateral primary sensorimotor cortices, left fusiform gyrus, and right cerebellum compared with controls (P < 0.001). Dorsolateral prefrontal and fusiform volumes showed negative associations with affective comorbidity, whereas motor cortex volume with impaired daily activity (P < 0.05). Connectivity was decreased between the cerebellar and limbic, and increased between the bilateral sensorimotor regions (P_FDR < 0.05). Higher pain intensity and unpleasantness correlated with enhanced bilateral sensorimotor and dorsolateral–medial prefrontal networks, respectively (P < 0.05).

Conclusion

Patients showed a decreased volume of cortical center for descending pain modulation and an increased volume of sensorimotor network, in association with suppressed descending pain modulatory and cerebellum–limbic networks and enhanced sensorimotor network during pain. Such structural and functional alterations might be part of cerebral pathophysiology of CLBP.

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Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

Abstract

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Paediatric ocular super glue injuries: assessment of two cases

In this report, we elaborate the clinical findings and the optimal management of two cases with ocular glue injuries in two paediatric patients. Both the patients were presented to the ocular emergency with completely closed eyelid and periocular erythema. The eyelids were completely closed due to matting of the eyelashes with glue retention up to lash roots. Thus, in both cases, after the application of local anaesthetic agent, immediate lash trimming was performed along with the removal of crystallised glue particles. However, the ocular surface showed only congestion in absence of any added corneal complications. Patients were followed up with standard treatment protocol as per chemical injuries. Until the end of 5 months, the clinical course was uneventful.

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Comorbid presentation of syringomyelia and Guillain-Barre syndrome, attributed to mycoplasma, in a 6-year-old female patient

Syringomyelia is the development of a fluid-filled cavity or syrinx within the spinal cord that can cause loss of sensation and muscle spasticity. Guillain-Barre syndrome (GBS) is a postinfection autoimmune disease, classified as an acute polyneuropathy. This report describes the emergency admission of a 6-year-old girl presenting with sudden pallor and pain in both lower limbs. The patient's reflexes were normal, as were the results of her sonography, radiography and biochemical tests; however, spinal MRI revealed extensive compartmentalised syringomyelia extending from C2 to T3. A sensory and motor nerve conduction study revealed a demyelinating type motor polyneuropathy which, along with positive Mycoplasma pneumoniae test, was suggestive of GBS. Intravenous immunoglobulin infusion showed excellent results. In conclusion, we report a rare paediatric case of syringomyelia coexisting with GBS. It is important to bear in mind the possibility of other coexisting diseases even if MRI reveals definitive characteristics of another condition.

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Diagnosis of a tick-borne coinfection in a patient with persistent symptoms following treatment for Lyme disease

A 67-year-old woman presented with 5 days of myalgias and fevers on completion of a 21-day course of amoxicillin for Lyme disease (Borrelia burgdorferi infection). She was found to have profound thrombocytopenia, as well as new anaemia and leucopenia. Workup revealed Babesia microti as the causative agent of her symptoms. The patient quickly improved after appropriate antimicrobial therapy directed against babesiosis was started. This case illustrates the importance of basic microbiology, including epidemiology and common vectors, when creating a differential diagnosis. Because the Ixodes scapularis tick can harbour and transmit multiple parasites simultaneously, the possibility of coinfection should be considered in any patient not responding to appropriate initial medical therapy.

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Desire for lasting long in bed led to contact allergic dermatitis and subsequent superficial penile gangrene: a dreadful complication of benzocaine-containing extended-pleasure condom

Description

A 30-year-old non-atopic, non-diabetic man presented with complaints of swelling, pain and patchy blackening of penile skin for the last 3 days. He stated that for improving the duration of sexual intercourse and for better sexual performance, he recently used a new brand of condom, which contained 5% benzocaine. He, however, denied about the use of any lubricants or topical substance at the time of sexual act. There was no history of fever, inguinal or scrotal swelling, genital trauma, insect bite, known drug allergy, substance abuse or similar complaints in the past. In the past, he was using non-medicated natural rubber latex condom for contraception without any adverse effects. Local examination revealed vesicle eruption, sloughing and patchy blackening of penile skin extending from prepuce to base of penis with a clear demarcation line with non-palpable inguinal lymph nodes suggestive of allergic contact dermatitis as shown in figure 1. The underlying...

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Knotted electric wire in urinary bladder: Can such complex foreign body be retrieved endoscopically!

Various types of foreign bodies have been recovered from the urinary bladder and urethra including telephone cables, pocket battery, little fish, pen tips and so on. Management of such cases include either endoscopic removal or open surgery. We report the case of an 18-year-old boy who inserted an electric wire in the urethra for eroticism and was managed by endoscopic removal following fragmentation of wire under local anaesthesia using holmium laser.

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Recurrent aseptic meningitis with PIGT mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab

We report the case of a patient with PIGT mutations who experienced recurrent aseptic meningitis 121 times over 16 years before developing paroxysmal nocturnal haemoglobinuria (PNH). Each episode was preceded by urticaria and arthralgia. After developing PNH, haemolysis occurred prior to meningitis. Flow cytometry revealed deficiency of the glycophosphatidylinositol (GPI)-anchored complement regulatory proteins, CD59 and CD55, and he was diagnosed with PNH. All the symptoms disappeared on administering eculizumab, an anti-C5 antibody. We did not detect mutation in PIGA, which is regarded as the cause of PNH. However, we detected a germ-line mutation and a somatic microdeletion in chromosome 20q including PIGT; PIGT is essential for transferring GPI anchor to the precursors of CD59 and CD55, which play important roles in complement regulation. Loss of these proteins leads to complement overactivation, causing inflammatory symptoms, including recurrent meningitis. PIGT mutations should be considered a novel pathogenesis of recurrent meningitis of unknown aetiology.

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Obstructive urosepsis secondary to ureteric herniation into the sciatic foramen

A 65-year-old female patient presented with a 2-day history of worsening right-sided abdominal pain and clinical signs of sepsis, on the background of a recent admission for pancolitis. Imaging revealed right ureteric herniation through the sciatic foramen with subsequent hydroureteronephrosis and radiological signs of severe pyelonephritis. The patient underwent emergency decompression with a percutaneous nephrostomy, followed by insertion of an antegrade stent to correct the ureteric hernia once the sepsis was appropriately treated. We describe the presentation and management of this unusual case of herniation of the right ureter into the sciatic foramen.

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Acromioclavicular joint cyst formation in a patient with rotator cuff-tear arthropathy: a rare cause of shoulder discomfort

We report a case of a 77-year-old man who presented to our shoulder department with a soft tissue mass on his right acromioclavicular (AC) joint. Previously attempted puncture aspiration had revealed serous fluid retention which recurred after each of several drainage attempts. Conventional radiography and MRI of the affected shoulder joint demonstrated a progressed cuff-tear arthropathy with an irreparable tear of the supraspinatus tendon, static superior migration of the humeral head, opening of the AC joint capsule and a superior joint-fluid 'eruption' and accumulation called 'Geyser sign'. Given that the patient's cuff-tear arthropathy was very well compensated, arthroscopic rotator cuff debridement and open cyst excision were performed. Closure of the superior aspect of the AC joint capsule was performed by the aid of a collagen matrix with additional closure of the deltotrapezial fascia. One year postoperatively, no cyst recurrence was noted.

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Atypical presentation of molar pregnancy

The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the emergency department with symptoms of acute abdomen and was treated as ruptured ectopic pregnancy. The woman underwent laparoscopy and evacuation of retained products of conception. Histological examination of uterine curettage confirmed the diagnosis of a complete hydatidiform mole. The woman was discharged home in good general condition with a plan for serial beta-human chorionic gonadotropin (beta-hCG) follow-up. Complete follow-up includes use of contraception and follow-up after beta-hCG is negative for a year.

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Lupus causing small bowel obstruction

A 20-year-old female patient was admitted to hospital in 2015 with 1 year history of recurrent abdominal pain, distension, borborygmi and nausea. The patient had a background of systemic lupus erythematous (SLE) diagnosed 4 years before, with skin, joint and renal involvement. The initial investigations have shown a long segment of ileal inflammation with upstream obstruction. Differential diagnoses were mainly SLE enteritis or concomitant Crohn's. Patient failed the initial conservative management and had a laparotomy with small bowel (SB) resection and ileostomy. The histology was suggestive of autoimmune enteritis. Although bowel involvement is a frequent feature of SLE, surgery for obstruction is extremely rare. Postoperatively, she had an emergency admission and was diagnosed with SB volvulus with perforation. She underwent further resection and stoma refashioning in 2016. As a consequence, she developed short gut syndrome. Eventually, the stoma was reversed and parenteral nutrition was stopped and weight became stable.

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Idiopathic macrocheilia

A 13-year-boy presented with painless swelling of upper and lower lips accompanied with gingival enlargement. The aetiology for these symptoms included vast pathological varieties but none of them could fit in. Clinical features were similar to orofacial graulomatosis but histopathological examination revealed chronic non-specific infection. Therefore, the final diagnosis was made as idiopathic macrocheilia through exclusion criteria. Management with intralesional triamcinolone acetonide 40 mg, twice a week for 3 weeks, resulted in significant remission in lip swelling without recurrence after a 6-month follow-up.

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Massive gastric dilatation leading to acute respiratory distress 1 year after a Nissen fundoplication

Acute massive gastric dilatation (AMGD) is a recognised complication after Nissen fundoplication.¹ A 63-year-old man recently presented to our emergency department in acute respiratory distress, acute abdominal pain and distension, having had an elective umbilical port incisional hernia repair a day prior. In the year preceding his presentation, the patient had undergone a laparoscopic paraoesophageal hiatus hernia repair and excision of sac, posterior cruropexy, dual mesh reinforcement of repair and 360° fundoplication, as a day case. In between these two events, the patient was asymptomatic, and had a free diet with no further medical or surgical intervention. We hereby present successful management and discuss implications of this exceptional yet potentially life-threatening complication.

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Diabetic ketoacidosis and thyroid storm: coexistence of a double trouble

Diabetic ketoacidosis (DKA) and thyrotoxic crisis are both endocrine emergencies. Here, we present a case of a patient who presented with DKA and on further evaluation was found to also have a thyrotoxic crisis. The coexistence of both of these endocrine emergencies simultaneously is extremely rare and heralds grave prognosis unless identified and treated promptly.

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Bilateral submandibular gland nodular oncocytic hyperplasia with papillary cystadenoma-like areas

A 57-year-old man presented in 2016 with a 4-month history of a right submandibular mass, having undergone left submandibular gland (SMG) excision in 2003. Imaging suggested a benign tumour and subsequent core biopsy findings suggested a nodular oncocytic hyperplasia, similar to the tumour removed from the contralateral side. This was confirmed on histological analysis following right submandibular gland excision which showed characteristic features of nodular oncocytic hyperplasia along with an unusual diffuse papillary cystadenoma-like ductal proliferation, similar to that seen in the 2003 specimen. A diagnosis of multinodular adenomatous oncocytic hyperplasia (MAOH) was rendered in order to communicate the unique histological features that have otherwise not been described in the literature. We believe that this is the first reported case of non-synchronous multinodular oncocytic hyperplasia and the first case affecting the submandibular glands.

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Gossypiboma masquerading as nephrocutaneous fistula

Nephrocutaneous fistula is a rare complication of surgical procedures involving the kidney. Fistula formation is also a complication seen in gossypiboma. We present the case of a patient who was initially suspected to have nephrocutaneous fistula after open pyelolithotomy. Later while undergoing open resection of fistula, he was found to have a retained surgical sponge (gossypiboma) near the lower pole of kidney. Gossypiboma is a term used for mass formed around a surgical sponge accidentally left in the body. It is most of the times not diagnosed by radiological imaging and thus results in unnecessary investigations to rule out other causes for the patient's symptoms. Having a high index of suspicion may lead to an earlier diagnosis. But the prevention of gossypiboma is of the utmost importance. A meticulous approach while operating by the surgeon and operating rooms staff is very important in doing so.

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Chronic urinary retention due to diabetic cystopathy masquedering as mesenteric cyst

Description

A 55-year-old previously diabetic man presented with progressive abdominal distension for the last three months. He denied any bowel/bladder complaints. His medical/surgical history was unremarkable. On examination his vitals were stable and a huge abdominal mass (10x11 cm) was palpable. The mass was having side-to-side mobility. There was no hepatosplenomegaly or clinically significant lymphadenoapathy. On evaluation with ultrasonography of abdomen and CT scan, there was evidence of huge, cystic and homogenous mass (13x11 cm) with clear margins occupying almost entire abdominal cavity (figure 1). There was no evidence of calcification, septations or nodules in the mass, and it appeared to be separate from both the kidneys and bowel. A provisional diagnosis of mesenteric cyst was made, and the patient was taken for laparotomy. A per-urethral catheter was placed intraoperatively and surgery was started. During laparotomy it came as an element of surprise that the swelling was actually chronically distended bladder...

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Fetishism in ADHD: an impulsive behaviour or a paraphilic disorder?

A boy with attention deficit and hyperactivity disorder (ADHD) presented with a fetish for and the subsequent stealing of female undergarments. He was predominantly inattentive and had been a slow learner. Psychological tests showed that he had significant cognitive and inattention problems without significant hyperactivity, and was at risk of dyslexia as well as conduct disorder.

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Pneumonia and bacteraemia caused by Gemella morbillorum in a previously healthy infant: first reported case in literature

A 5-month-old baby presented with a low-grade fever and tachypnoea and was found to have right upper lobe consolidation on chest radiograph. He was admitted with the diagnosis of bronchopneumonia and the treatment protocol for pneumonia was initiated. Blood culture samples were collected, and he was started on a course of intravenous amoxicillin–clavulanate. Blood culture results displayed pansensitive Gemella morbillorum bacteraemia and he was continued on intravenous antibiotic to which he responded in a short period and was discharged in good condition on the fourth day.

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Gastric emphysema secondary to severe vomiting: a comparative review of 14 cases

Gastric emphysema is characterised by the presence of air within the wall of the stomach. The radiographic finding of gastric emphysema with hepatic portal venous gas is classically an ominous sign, associated with a high mortality rate. We report one case from our clinical experience and undertake a review of the previously reported cases of vomiting-induced gastric emphysema retrieved from the PubMed. A total of 14 cases were found to date. The mean age at the time of diagnosis was 45.6 years (range, 9 months to 81 years). Computed tomography abdomen was the frequently used diagnostic modality. Interestingly, conservative treatment led to a clinical cure and resolution of gastric emphysema as well as the associated hepatic portal venous gas in most of the patients. This review illustrates that vomiting-related gastric emphysema entails a more benign course and surgical intervention can be avoided with a prompt aetiology establishment in these patients.

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Aneurysmal dilation of the vein of Galen and straight sinus with resultant obstructive hydrocephalus

Description

A 20-year-old woman was admitted to the emergency department on a previous occasion with tonic-clonic seizures. Her medical history was significant for headaches and hypertension. The headaches were associated with nausea and vomiting. She had no history of developmental delay or epilepsy. CT scan of the brain showed signs of obstructive hydrocephalus due to venous hypertension as a result of vein of Galen malformation, and hence a ventriculoperitoneal shunt was placed. Now on follow-up, her MRI brain demonstrates a round flow void in the suprapineal cisterns with engorged straight sinus, compatible with vein of Galen arteriovenous fistulous communication and shunting (figure 1). The resultant venous hypertension leads to mild to moderate compensated hydrocephalus.

Figure 1

(A) Axial T2, (B) axial T1 and (C) sagittal T2 MRI brain. MRI brain demonstrates a round flow void in the suprapineal cisterns with engorged straight sinus (green arrow),...

https://ift.tt/2zyNwsj

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma

Abstract

Background

To investigate the effect of DACH1 over-expression on proliferation and invasion of laryngeal squamous cell carcinoma (LSCC).

Methods

The 120 cases of LSCC tumors and 114 adjacent non-neoplastic tissues were collected to detect the expression of DACH1 by immunohistochemistry. The changes of DACH1 expression from each group were assessed and correlated to the clinical parameters of the patients. Plasmid-DACH1 was transfected into Hep-2 cells to up-regulate the expression of DACH1C. Real-time PCR, Western blot, CCK8 and transwell assay were used to verify the cell proliferation and invasion after plasmid-DACH1 transfection.

Results

The results indicated that DACH1 was downregulated in LSCC tissues as compared to corresponding adjacent non-neoplastic tissues. Decreased expression of DACH1 was found in the tumors upraglottic tumor, lymph node metastases, T3–4 stage and advanced clinical stage. In Hep-2 cells, transfection with plasmid-DACH1 could suppress cell proliferation, invasion and induce G1 phase extension in cell cycle.

Conclusions

DACH1 may act as a tumor suppressor gene and could be a potential target for therapeutic intervention of LSCC.

https://ift.tt/2xJXndl

Neurofilaments as biomarkers in neurological disorders

Khalil, M; Teunissen, CE; Otto, M; Piehl, F; Sormani, MP; Gattringer, T; Barro, C; ... Kuhle, J; + view all Khalil, M; Teunissen, CE; Otto, M; Piehl, F; Sormani, MP; Gattringer, T; Barro, C; Kappos, L; Comabella, M; Fazekas, F; Petzold, A; Blennow, K; Zetterberg, H; Kuhle, J; - view fewer (2018) Neurofilaments as biomarkers in neurological disorders. Nature Reviews Neurology , 14 pp. 577-589. 10.1038/s41582-018-0058-z .

https://ift.tt/2xDEE36

Law and Polity: Some Philosophical Preliminaries

Letsas, G; (2018) Law and Polity: Some Philosophical Preliminaries. International Journal of Constitutional Law (In press).

https://ift.tt/2Ik4L35

Political Testimony

Van Wietmarschen, JG; (2018) Political Testimony. Politics, Philosophy and Economics (In press). Green open access

https://ift.tt/2xIBg7c

Neodymium in the oceans: a global database, a regional comparison and implications for palaeoceanographic research.

van de Flierdt, T; Griffiths, AM; Lambelet, M; Little, SH; Stichel, T; Wilson, DJ; (2016) Neodymium in the oceans: a global database, a regional comparison and implications for palaeoceanographic research. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences , 374 (2081) 10.1098/rsta.2015.0293 . Green open access

https://ift.tt/2ImNQNw

Book Review: Essays in Collective Epistemology

Van Wietmarschen, JG; (2017) Book Review: Essays in Collective Epistemology. The Philosophical Quarterly (In press).

https://ift.tt/2xIy9Mv

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

Li, L; Jiao, X; D'Atri, I; Ono, F; Nelson, R; Chan, C-C; Nakaya, N; ... Hejtmancik, JF; + view all Li, L; Jiao, X; D'Atri, I; Ono, F; Nelson, R; Chan, C-C; Nakaya, N; Ma, Z; Ma, Y; Cai, X; Zhang, L; Lin, S; Hameed, A; Chioza, BA; Hardy, H; Arno, G; Hull, S; Khan, MI; Fasham, J; Harlalka, GV; Michaelides, M; Moore, AT; Akdemir, ZHC; Jhangiani, S; Lupski, JR; Cremers, FPM; Qamar, R; Salman, A; Chilton, J; Self, J; Ayyagari, R; Kabir, F; Naeem, MA; Ali, M; Akram, J; Sieving, PA; Riazuddin, S; Baple, EL; Riazuddin, SA; Crosby, AH; Hejtmancik, JF; - view fewer (2018) Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genetics , 14 (8) , Article e1007504. 10.1371/journal.pgen.1007504 . Green open access

https://ift.tt/2InTQFy

Visualization of Water-Induced Surface Segregation of Polarons on Rutile TiO2(110)

Yim, CM; Chen, J; Zhan, Y; Shaw, B-J; Pang, CL; Grinter, DC; Bluhm, H; ... Thornton, G; + view all Yim, CM; Chen, J; Zhan, Y; Shaw, B-J; Pang, CL; Grinter, DC; Bluhm, H; Salmeron, M; Muryn, CA; Michaelides, A; Thornton, G; - view fewer (2018) Visualization of Water-Induced Surface Segregation of Polarons on Rutile TiO2(110). Journal of Physical Chemistry Letters , 9 (17) pp. 4865-4871. 10.1021/acs.jpclett.8b01904 .

https://ift.tt/2xJTrJB

Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Matias, D; Balca-Silva, J; da Graca, GC; Wanjiru, CM; Macharia, LW; Nascimento, CP; Roque, NR; ... Moura-Neto, V; + view all Matias, D; Balca-Silva, J; da Graca, GC; Wanjiru, CM; Macharia, LW; Nascimento, CP; Roque, NR; Coelho-Aguiar, JM; Pereira, CM; Dos Santos, MF; Pessoa, LS; Lima, FRS; Schanaider, A; Ferrer, VP; Leite de Sampaio e Spohr, TC; Moura-Neto, V; - view fewer (2018) Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors. Frontiers in Cellular Neuroscience , 12 , Article 235. 10.3389/fncel.2018.00235 . Green open access

https://ift.tt/2InTNJS

Maximizing gain in high-throughput screening using conformal prediction

Svensson, F; Afzal, AM; Norinder, U; Bender, A; (2018) Maximizing gain in high-throughput screening using conformal prediction. Journal of Cheminformatics , 10 (7) 10.1186/s13321-018-0260-4 . Green open access

https://ift.tt/2xIbvUC

Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?

Guerreiro, R; Orme, T; Naj, AC; Kuzma, AB; Schellenberg, GD; Bras, J; (2018) Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers? Neuropathology and Applied Neurobiology 10.1111/nan.12517 . (In press).

https://ift.tt/2Ikg8Z3

Statins after intracranial haemorrhage: seizing a new opportunity

Ziff, OJ; Werring, DJ; (2018) Statins after intracranial haemorrhage: seizing a new opportunity. British Journal of Clinical Pharmacology 10.1111/bcp.13754 . (In press).

https://ift.tt/2xImrkR

Author Correction: Amplitude of travelling front as inferred from 14C predicts levels of genetic admixture among European early farmers

Silva, F; Linden, MV; (2018) Author Correction: Amplitude of travelling front as inferred from 14C predicts levels of genetic admixture among European early farmers. Scientific Reports , 8 , Article 12809. 10.1038/s41598-018-30976-8 . Green open access

https://ift.tt/2InTgHS

Parallelised photoacoustic signal acquisition using a Fabry-Perot sensor and a camera-based interrogation scheme

Saeb Gilani, T; Villringer, C; Zhang, E; Gundlach, H; Buchmann, J; Schrader, S; Laufer, J; (2018) Parallelised photoacoustic signal acquisition using a Fabry-Perot sensor and a camera-based interrogation scheme. In: (Proceedings) Proceedings of SPIE, Photons Plus Ultrasound: Imaging and Sensing 2018 - SPIE BiOS. SPIE Green open access

https://ift.tt/2xIme13

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Barbu, MC; Zeng, Y; Shen, X; Cox, SR; Clarke, TK; Gibson, J; Adams, MJ; ... Nivard, MG; + view all Barbu, MC; Zeng, Y; Shen, X; Cox, SR; Clarke, TK; Gibson, J; Adams, MJ; Johnstone, M; Haley, CS; Lawrie, SM; Deary, IJ; Wray, NR; Ripke, S; Mattheisen, M; Trzaskowski, M; Byrne, EM; Abdellaoui, A; Adams, MJ; Agerbo, E; Air, TM; Andlauer, TFM; Bacanu, SA; Bækvad-Hansen, M; Beekman, ATF; Bigdeli, TB; Binder, EB; Blackwood, DHR; Bryois, J; Buttenschøn, HN; Bybjerg-Grauholm, J; Cai, N; Castelao, E; Christensen, JH; Clarke, TK; Coleman, JRI; Colodro-Conde, L; Couvy-Duchesne, B; Craddock, N; Crawford, GE; Davies, G; Deary, IJ; Degenhardt, F; Derks, EM; Direk, N; Dolan, CV; Dunn, EC; Eley, TC; Escott-Price, V; Hassan Kiadeh, FF; Finucane, HK; Forstner, AJ; Frank, J; Gaspar, HA; Gill, M; Goes, FS; Gordon, SD; Grove, J; Hall, LS; Hansen, CS; Hansen, TF; Herms, S; Hickie, IB; Hoffmann, P; Homuth, G; Horn, C; Hottenga, JJ; Hougaard, DM; Ising, M; Jansen, R; Jorgenson, E; Knowles, JA; Kohane, IS; Kraft, J; Kretzschmar, WW; Krogh, J; Kutalik, Z; Li, Y; Lind, PA; MacIntyre, DJ; MacKinnon, DF; Maier, RM; Maier, W; Marchini, J; Mbarek, H; McGrath, P; McGuffin, P; Medland, SE; Mehta, D; Middeldorp, CM; Mihailov, E; Milaneschi, Y; Milani, L; Mondimore, FM; Montgomery, GW; Mostafavi, S; Mullins, N; Nauck, M; Ng, B; Nivard, MG; - view fewer (2018) Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 10.1016/j.bpsc.2018.07.006 . (In press). Green open access

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Aiming higher to bend the curve of biodiversity loss

Mace, GM; Barrett, M; Burgess, ND; Cornell, SE; Freeman, R; Grooten, M; Purvis, A; (2018) Aiming higher to bend the curve of biodiversity loss. Nature Sustainability , 1 pp. 448-451. 10.1038/s41893-018-0130-0 .

https://ift.tt/2xIlFUZ

An Integrated Mathematical Model of Cellular Cholesterol Biosynthesis and Lipoprotein Metabolism

Pool, F; Sweby, PK; Tindall, MJ; (2018) An Integrated Mathematical Model of Cellular Cholesterol Biosynthesis and Lipoprotein Metabolism. Processes , 6 (8) , Article 134. 10.3390/pr6080134 . Green open access

https://ift.tt/2ImnMlM

Rethinking Muslim migration: frameworks, flux and fragmentation

Redclift, V; Rajina, F; (2017) Rethinking Muslim migration: frameworks, flux and fragmentation. Ethnic and Racial Studies , 40 (3) pp. 407-412. 10.1080/01419870.2017.1249494 . Green open access

https://ift.tt/2xIluch

Correction: Associations of behavioural risk factors and health status with changes in physical capability over 10 years of follow-up: The MRC National Survey of Health and Development

Cooper, R; Muniz-Terrera, G; Kuh, D; (2018) Correction: Associations of behavioural risk factors and health status with changes in physical capability over 10 years of follow-up: The MRC National Survey of Health and Development. [Corrigendum]. BMJ Open , 8 (5) 10.1136/bmjopen-2015-009962corr1 . Green open access

https://ift.tt/2ImgjDh

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders

Madsen, RR; Vanhaesebroeck, B; Semple, RK; (2018) Cancer-Associated PIK3CA Mutations in Overgrowth Disorders. Trends in Molecular Medicine 10.1016/j.molmed.2018.08.003 . (In press). Green open access

https://ift.tt/2xHDi7z

A spatial frequency spectral peakedness model predicts discrimination performance of regularity in dot patterns

Protonotarios, ED; Griffin, LD; Johnston, A; Landy, MS; (2018) A spatial frequency spectral peakedness model predicts discrimination performance of regularity in dot patterns. Vision Research , 149 pp. 102-114. 10.1016/j.visres.2018.06.008 .

https://ift.tt/2ImfESj

TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Conditions: Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Gastric Cancer
Interventions: Drug: TAS 102; Drug: Ramucirumab 10 MG/ML Intravenous Solution [CYRAMZA]
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Not yet recruiting

https://ift.tt/2N6PKT1

Diagnostic Accuracy of Human Transcriptional Activator(MYB) Expression by ELISA Technique Versus Immmunohistochemistry in Detecting Salivary Gland Carcinomas

Conditions: Malignant Neoplasm of Salivary Gland; Benign Neoplasm of Salivary Gland
Intervention: Device: enzyme linked immunosorbent assay (ELISA)
Sponsor: Cairo University
Not yet recruiting

https://ift.tt/2R1Qe05

Interferon Gamma and Interleukin 8 Gene Polymorphisms in Patients with Hepatitis C virus related Oral Lichen Planus

Publication date: Available online 26 September 2018

Source: Archives of Oral Biology

Author(s): Noha A. Azab, Lobna Abd El Salam, Enji Ahmed, Marwa El Sharkawy, Aisha ElSharkawy, Shahira G. El Asheiry

Abstract

Objectives

This study aimed to determine the association of rs2430561 and rs4073 polymorphisms in the Interferon gamma (IFN-ɤ) and Interleukin 8 (IL-8) genes, respectively, with hepatitis C virus-related oral lichen planus and disease severity.

Design

This is a case-control study. 60 subjects were equally divided into patients with and without oral lichen planus. They were further subdivided into hepatitis C virus seropositive and seronegative patients. All patients were genotyped for IFN-γ rs2430561 thymine to adenine (T > A) and IL-8 rs4073 adenine to thymine (A > T) polymorphisms. All patients with oral lichen planus had their lesions measured and documented using the Escudier scoring system.

Results

Disease activity was significantly higher in the "oral lichen planus/hepatitis C virus-positive" patients than in the "oral lichen planus/hepatitis C virus-negative" patients (P = 0.003). IFN-γ rs2430561 T > A and IL-8 rs4073 A > T genotypes and allele frequencies were not associated with the oral lichen planus group or the normal group. Stratification of the two groups into HCV and non-HCV-infected patients or into erosive and non-erosive types revealed no significant associations. The "A-allele-containing" genotypes of IL-8 rs4073 A > T were significantly more prevalent in the patients with oral lichen planus than in those without.

Conclusion

Hepatitis C virus infection is associated with the development of erosive oral lichen planus. The A-allele of IL-8 rs4073 A > T may have a role in the development and progression of oral lichen planus.

https://ift.tt/2OTAGdr

Evaluation of immunophenotyping, proliferation and osteogenic differentiation potential of SSEA-4 positive stem cells derived from pulp of deciduous teeth

Publication date: Available online 26 September 2018

Source: Archives of Oral Biology

Author(s): Farzaneh Aghajani, Somaieh Kazemnejad, Tabassom Hooshmand, Zahra Ghaempanah, Amir-Hassan Zarnani

Abstract

Objectives

Despite the increased interest in stem cells isolated from remnant pulp of deciduous teeth, no specific marker has been yet established for them. The present study aimed to investigate whether SSEA-4 (stage-specific embryonic antigen) would be a suitable marker to isolate stem cells from Human Exfoliated Deciduous teeth (SHEDs) in order to increase its differentiation potential toward osseous tissue.

Design

The SHEDs were isolated and the expression patterns of mesenchymal, hematopoietic and embryonic stem cell markers were assessed. The cells were then divided into two groups of SSEA-4(+) and unsorted SHEDs and the cell proliferation rate and population-doubling-time (PDT) were calculated. Subsequently, the differentiation potentials were examined through alizarin-red staining and Quantitative real time-PCR (qRT-PCR).

Results

Isolated cells were spindle-shaped with a high expression of mesenchymal stem cell markers and weak expression of hematopoietic markers. The mean expression of Oct-4 was 68.77%±1.28. Despite similar proliferation rates between SSEA-4(+) and unsorted SHEDs, because of differences in the shape of the growth curves, PDT was lower in unsorted SHEDs (P = 0.2 × 10^-4). Alizarin-red staining showed similar calcium deposition in both groups. Upon differentiation, the expression of osteocalcin was higher in unsorted SHEDs (P = 0.043), while, the expression of alkaline phosphatase was lower (P<0.001). The parathyroid hormone receptor (PTHR) expression was not significantly different (P = 0.0625).

Conclusions

The results of the present study revealed that SHEDs have high differentiation potentials even in the unsorted cells. Although, the SSEA-4-positive SHEDs showed slightly better osteogenic potential, the differences were not abundant to link SSEA-4 expression with superior differentiation potency.

https://ift.tt/2zzTJUU

Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience

Publication date: Available online 26 September 2018

Source: American Journal of Otolaryngology

Author(s): Esther Cheng, David Grande, John Leonetti

Abstract

Purpose

The goal of this study was to describe the incidence of and our long-term results in the management of spontaneous temporal bone CSF leak and to determine if there is any association with an increase in body mass index (BMI).

Methods

This was an Institutional Review Board (IRB) approved retrospective review of 58 patients who underwent repair of spontaneous temporal bone CSF leaks by a single surgeon at a tertiary care academic medical center between 1988 and 2017. Patients with CSF leaks due to trauma, iatrogenic injury, or chronic infection were excluded. Surgical approaches included middle cranial fossa, transmastoid, or a combination of both. Cases were divided into three decades. Patient demographics, clinical features, audiologic results, imaging studies, operative findings, complications, and long-term results were reviewed with a specific emphasis on the potential correlation with BMI.

Results

The average BMI was 32. There was a statistically significant increase in BMI between the two most recent decades (p = 0.044). The middle cranial fossa was the most commonly utilized approach. Multiple tegmen defects were often noted on imaging and intraoperatively.

Conclusion

There is an increase in the incidence of spontaneous CSF leaks possibly associated with an increase in BMI in the United States over the last 30 years.

https://ift.tt/2DzYL7E

Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage

Publication date: Available online 26 September 2018

Source: American Journal of Otolaryngology

Author(s): Kaitian Chen, Lanying Wen, Ling Zong, Min Liu, Jincangjian Sun, Xuan Wu

Abstract

Objective

To explore the hearing outcomes and prognostic factors in patients with sudden sensorineural hearing loss resulting from inner ear hemorrhage.

Methods

42 patients (22 male and 20 female) were recruited from January 2016 to December 2017. Intravenous methylprednisolone and/or intratympanic corticosteroid were used as salvage therapy. The main measures included systemic risk factors and audiometric outcomes as proposed by American Academy of Otolaryngology-Head and Neck Surgery Hearing Loss Scale. All individuals were assessed at baseline, discharge (2 weeks post-treatment) and at 1, 3 and 6 months.

Results

The mean ages of patients were 39.3 ± 14.8 yrs. Cardiovascular disorders were seen in 19.0–33.3% of cases. Restoration of hearing and speech discrimination abilities were assessed at the first month post-treatment versus initial levels (95.5 ± 15.5 vs. 109.2 ± 9.6 dB, p = 0.000; and 17.6 ± 24.4 vs. 1.3 ± 4.0%, p = 0.003, respectively). Word recognition scores continued to recover at month 6 (38.7 ± 35.4%, p = 0.000), whereas puretone ceased to change (90.8 ± 16.2 dB, p = 0.139). The final percentages of complete, partial and no recovery were 0%, 57.1% and 42.9% respectively. The prognosis was independent of accompanying systemic risk factors as analyzed in this study. Intratympanic intervention was associated with improved word recognition scores, although intravenous corticosteroid was not.

Conclusions

Profound sudden sensorineural hearing loss caused by inner ear hemorrhage often has an unsatisfactory prognosis. However, this cohort did experience partial audiological recovery with delayed onset. Immediate and effective intratympanic corticosteroid may have therapeutic potential for this intractable disease.

https://ift.tt/2R0ZQIl

CD8+iTregs attenuate glomerular endothelial cell injury in lupus-prone mice through blocking the activation of p38 MAPK and NF-κB

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Ya Liu, Weijuan Deng, Qiaoyun Meng, Xiaonan Qiu, Dong Sun, Chun Dai

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease. Endothelial cell injury plays an important role in the inflammatory processes associated with SLE. CD4+Foxp3+regulatory T cells (Tregs) reduce the injury to endothelial cells induced by inflammatory factors. As a newly identified regulatory T cell, we previously reported that CD8+CD103+iTregs had similar effects to those of CD4+iTregs in the process of immunoregulation. In this paper, we further explored the effect and mechanism of CD8+iTregs on endothelial cell injury. The expressions of vascular cellular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in MRL/lpr mouse glomerular endothelial cells (lupus-MGECs) were estimated by quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay and Western blotting. The lupus-MGEC apoptosis rate was detected by flow cytometry and the adhesion of monocyte-like cells to lupus-MGECs exposed to lipopolysaccharide (LPS) was determined by the adhesion assay. Additionally, the expressions of P-p38, P-NF-κB and P-IκBα were detected by Western blotting. The results showed that LPS increased the expressions of VCAM-1, ICAM-1, IFN-γ, TNF-α, IL-6 and MCP-1 in lupus-MGECs, while CD8+iTregs significantly decreased the levels of these adhesion molecules and inflammatory mediators. Furthermore, CD8+iTregs alleviated lupus-MGEC apoptosis and inhibited the adhesion of monocyte-like cells to lupus-MGECs. Both nuclear factor-κB (NF-κB) and p38 mitogen-activated protein kinase (MAPK), activated by LPS, were suppressed by CD8+iTregs. These findings suggest that CD8+iTregs attenuate LPS-induced glomerular endothelial cell injury through blocking the activation of p38 MAPK and NF-κB in lupus-MGECs. The protective effect of CD8+iTregs indicates their possible therapeutic application in Lupus nephritis.

https://ift.tt/2DBh2Si

Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection

Publication date: Available online 27 September 2018

Source: Allergologia et Immunopathologia

Author(s): B. Pourakbari, R. Hosseinpour Sadeghi, S. Mahmoudi, N. Parvaneh, S. Keshavarz Valian, S. Mamishi

Abstract

Introduction

Disseminated BCG infections among other complications of Bacillus Calmette–Guérin (BCG) vaccine are rare and have occurred in children with immunodeficiency disorders such as mendelian susceptibility to mycobacterial disease (MSMD) which could be due to defects in some elements of IL-12/IFN-γ axis. MSMD-causing mutations have been identified in 10 genes during the last two decades. Among them, mutations in the IL12Rβ1 and IFNγR1 genes constitute about 80% of recorded cases of MSMD syndrome. The aim of this study was to investigate IL-12Rβ1 and IFN-γR1 deficiencies in patients with disseminated BCG infection.

Methods

This study was performed on 31 children with disseminated BCG infections who referred to children's medical center. Whole blood cell culture was performed in presence of BCG, IL-12 and IFN-γ stimulators. The supernatants were assayed for IFN-γ and IL-12p70 by ELISA method. In order to evaluate IL12Rβ1 and IFN-γR1 receptors expression, flow cytometry staining was performed on the patients' T-cells stimulated with PHA.

Results

Flow cytometry staining of 31 Iranian patients with disseminated BCG infections with the average age of 43 months showed lack of the expression of IL-12Rβ1 and IFN-γR1 genes in PHA-T-cells of the nine and one patients, respectively in whom the incomplete production of IFN-γ and IL-12 was reported by ELISA. Among these 10 patients, eight cases had related parents (80%).

Conclusion

It is recommended that to avoid BCG complications, screening be performed for MSMD before BCG inoculation in individuals with positive family history of primary immunodeficiency diseases and inhabitants of areas with high frequency of consanguinity.

https://ift.tt/2NIQR0H

Association of M470V polymorphism of CFTR gene with variability of clinical expression of asthma: Case-report study

Publication date: Available online 27 September 2018

Source: Allergologia et Immunopathologia

Author(s): Imen Wahabi, Sondess Hadj Fredj, Malek Nefzi, Rym Dabboubi, Hajer Siala, Fatma Khalsi, Khedija Bousetta, Taieb Messaoud

Abstract

Introduction and Objectives

Asthma is a complex genetic disorder. Several genes have been found associated with asthma. The cystic fibrosis transmembrane conductance regulator (CFTR) gene is one of them. The aim of this study was to perform a comparative analysis of the genotype and allele frequency distributions of the biallelic marker M470V within the CFTR gene on mutant and wide chromosomes.

Patients and methods

The molecular approach consists in the genotyping of the M470V marker by the PCR-RFLP technique in 105 asthmatic patients, aged between four months and 17 years, and 105 healthy subjects.

Results

We found a significant difference in the genotype frequencies between the two studied groups (χ² = 9.855, P = 0.007). The V/V genotype was over represented in the asthmatic group as compared to the controls (32.38% vs. 16.19%). Whereas, the M/V genotype is more frequent in healthy subjects (40.95% vs. 28.71%). We also noted a significant difference in allelic distribution of M470V with associated diseases (χ² = 9.610, P = 0.022).

Conclusions

The present study is the first report on the distribution of the M470V polymorphism in asthmatic Tunisian patients. We noticed that the M470V variant could modulate the clinical phenotype of asthmatic patients. This preliminary study will establish the molecular basis of this disease in Tunisia.

https://ift.tt/2IpXMpH

Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel

Publication date: Available online 26 September 2018

Source: Allergologia et Immunopathologia

Author(s): A. Chiricozzi, A. Belloni Fortina, E. Galli, G. Girolomoni, I. Neri, G. Ricci, M. Romanelli, D. Peroni

Abstract

Introduction and Objectives

Atopic dermatitis (AD) is the most common cutaneous inflammatory disease in both adults and children. Although emerging therapeutic approaches are being investigated for the management of pediatric AD, it still needs to be managed with conventional treatments. This consensus document is aimed at providing an update on general management and therapies of pediatric AD, defining practical recommendations for using both topical and systemic agents.

Material and Methods

A panel of experts consisting of dermatologists and pediatricians were convened in order to define statements, through a Delphi process, standardizing the management of AD in pediatric subjects in a real-world setting.

Results

A set of practical recommendations obtaining an at least 75% agreement was presented.

Conclusions

This set of practical recommendations represents a simple and fast snapshot on the pediatric use of common anti-AD therapeutics.

https://ift.tt/2NMpLFK

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

Speranzini, V; Rotili, D; Ciossani, G; Pilotto, S; Marrocco, B; Forgione, M; Lucidi, A; ... Mattevi, A; + view all Speranzini, V; Rotili, D; Ciossani, G; Pilotto, S; Marrocco, B; Forgione, M; Lucidi, A; Forneris, F; Mehdipour, P; Velankar, S; Mai, A; Mattevi, A; - view fewer (2016) Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features. Science Advances , 2 (9) , Article e1601017. 10.1126/sciadv.1601017 . Green open access

https://ift.tt/2xWedVC

Almost sure productivity

Aguirre, A; Barthe, G; Hsu, J; Silva, A; (2018) Almost sure productivity. In: Proceedings of the 45th International Colloquium on Automata, Languages, and Programming (ICALP 2018). (pp. 113.1-113.15). LIPIcs , Schloss Dagstuhl - Leibniz-Zentrum für Informatik: Prague, Czech Republic. Green open access

https://ift.tt/2NHn884

Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Koohy, H; Bolland, DJ; Matheson, LS; Schoenfelder, S; Stellato, C; Dimond, A; Várnai, C; ... Varga-Weisz, PD; + view all Koohy, H; Bolland, DJ; Matheson, LS; Schoenfelder, S; Stellato, C; Dimond, A; Várnai, C; Chovanec, P; Chessa, T; Denizot, J; Garcia, RM; Wingett, SW; Freire-Pritchett, P; Nagano, T; Hawkins, P; Stephens, L; Elderkin, S; Spivakov, M; Fraser, P; Corcoran, AE; Varga-Weisz, PD; - view fewer (2018) Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells. Genome Biology , 19 (1) , Article 126. 10.1186/s13059-018-1489-y . Green open access

https://ift.tt/2xU54Nt

Trait Emotional Intelligence Profiles of Parents With Drug Addiction and of Their Offspring

Aslanidou, GS; Petrides, KV; Stogiannidou, A; (2018) Trait Emotional Intelligence Profiles of Parents With Drug Addiction and of Their Offspring. Frontiers in Psychology , 9 , Article 1633. 10.3389/fpsyg.2018.01633 . Green open access

https://ift.tt/2NHnCLq

Review and analysis of Chilean dental undergraduate education: curriculum composition and profiles of first year dental students

Venturelli Garay, RE; Watt, RG; (2018) Review and analysis of Chilean dental undergraduate education: curriculum composition and profiles of first year dental students. Human Resources for Health , 16 (1) , Article 48. 10.1186/s12960-018-0314-8 . Green open access

https://ift.tt/2xTV8DL

Routinely measured hematological parameters and prediction of recurrent vascular events in patients with clinically manifest vascular disease

Kofink, D; Muller, SA; Patel, RS; Dorresteijn, JAN; Berkelmans, GFN; de Groot, MCH; van Solinge, WW; ... SMART Study Group, ; + view all Kofink, D; Muller, SA; Patel, RS; Dorresteijn, JAN; Berkelmans, GFN; de Groot, MCH; van Solinge, WW; Haitjema, S; Leiner, T; Visseren, FLJ; Hoefer, IE; Asselbergs, FW; SMART Study Group, ; - view fewer (2018) Routinely measured hematological parameters and prediction of recurrent vascular events in patients with clinically manifest vascular disease. PLoS One , 13 (9) , Article e0202682. 10.1371/journal.pone.0202682 . Green open access

https://ift.tt/2NM9zUS

Off the pedestal, on the stage: Animation and de-animation in art and theatre

Satz, A; (2002) Off the pedestal, on the stage: Animation and de-animation in art and theatre. Doctoral thesis (PhD), UCL (University College London). Green open access

https://ift.tt/2xPtrvE

Optical Phase Lock Loop as High-Quality Tuneable Filter for Optical Frequency Comb Line Selection

Balakier, K; Shams, H; Fice, MJ; Ponnampalam, L; Graham, CS; Renaud, CC; Seeds, AJ; (2018) Optical Phase Lock Loop as High-Quality Tuneable Filter for Optical Frequency Comb Line Selection. Journal of Lightwave Technology , 36 (19) pp. 4646-4654. 10.1109/JLT.2018.2848961 . Green open access

https://ift.tt/2NNIQaR

Body Composition Growth Patterns in Early Infancy: A Latent Class Trajectory Analysis of the Ethiopian iABC Birth Cohort

Andersen, GS; Wibaek, R; Kaestel, P; Girma, T; Admassu, B; Abera, M; Vistisen, D; ... Wells, JCK; + view all Andersen, GS; Wibaek, R; Kaestel, P; Girma, T; Admassu, B; Abera, M; Vistisen, D; Jorgensen, ME; Michaelsen, KF; Friis, H; Wells, JCK; - view fewer (2018) Body Composition Growth Patterns in Early Infancy: A Latent Class Trajectory Analysis of the Ethiopian iABC Birth Cohort. Obesity , 26 (7) pp. 1225-1233. 10.1002/oby.22197 .

https://ift.tt/2xQyHiE

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

Shamsabadi, A; Chudasama, V; (2018) A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement. Chemical Communications 10.1039/c8cc06556j . (In press). Green open access

https://ift.tt/2NHmNSQ

Active learning reveals underlying decision strategies

Parpart, P; Schulz, E; Speekenbrink, M; Love, B; (2017) Active learning reveals underlying decision strategies. In: Cold Spring Harbor Laboratory Press (In press).

https://ift.tt/2xPt4RM

Landmark study raises the bar for interventional oncology.

Shiao, J; Winter, H; Sharma, RA; (2016) Landmark study raises the bar for interventional oncology. Future Oncology , 12 (15) pp. 1747-1749. 10.2217/fon-2016-0212 . Green open access

https://ift.tt/2NI2On3

Over-expression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.

De Castro, SCP; Gustavsson, P; Marshall, AR; Gordon, WM; Galea, G; Nikolopoulou, E; Savery, D; ... Greene, NDE; + view all De Castro, SCP; Gustavsson, P; Marshall, AR; Gordon, WM; Galea, G; Nikolopoulou, E; Savery, D; Rolo, A; Stanier, P; Andersen, B; Copp, AJ; Greene, NDE; - view fewer (2018) Over-expression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Human Molecular Genetics 10.1093/hmg/ddy313 . (In press). Green open access

https://ift.tt/2xPsVxI

Low-noise 1.3 μm InAs/GaAs quantum dot laser monolithically grown on silicon

Liao, M; Chen, S; Liu, Z; Wang, Y; Ponnampalam, L; Zhou, Z; Wu, J; ... Liu, H; + view all Liao, M; Chen, S; Liu, Z; Wang, Y; Ponnampalam, L; Zhou, Z; Wu, J; Tang, M; Shutts, S; Liu, Z; Smowton, P; Yu, S; Seeds, A; Liu, H; - view fewer (2018) Low-noise 1.3 μm InAs/GaAs quantum dot laser monolithically grown on silicon. Photonics Research 10.1364/PR.99.099999 . (In press).

https://ift.tt/2NKfutB

Liver transplantation in elderly patients: a systematic review and first meta-analysis

Gómez Gavara, C; Esposito, F; Gurusamy, K; Salloum, C; Lahat, E; Feray, C; Lim, C; Gómez Gavara, C; Esposito, F; Gurusamy, K; Salloum, C; Lahat, E; Feray, C; Lim, C; Azoulay, D; - view fewer (2018) Liver transplantation in elderly patients: a systematic review and first meta-analysis. HPB 10.1016/j.hpb.2018.07.025 . (In press).

https://ift.tt/2xSWjTU

Vesignieite: An S=1/2 Kagome Antiferromagnet with Dominant Third-Neighbor Exchange

Boldrin, D; Fak, B; Canevet, E; Ollivier, J; Walker, HC; Manuel, P; Khalyavin, DD; Boldrin, D; Fak, B; Canevet, E; Ollivier, J; Walker, HC; Manuel, P; Khalyavin, DD; Wills, AS; - view fewer (2018) Vesignieite: An S=1/2 Kagome Antiferromagnet with Dominant Third-Neighbor Exchange. Physical Review Letters , 121 (10) 10.1103/PhysRevLett.121.107203 . Green open access

https://ift.tt/2NKfhqj

On multifractals: a non-linear study of actigraphy data

Franca, LGS; Montoya, P; Miranda, JGV; (2018) On multifractals: a non-linear study of actigraphy data. Physica A: Statistical Mechanics and its Applications (In press).

https://ift.tt/2xSp1nW

Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society-USA Panel

Günthard, HF; Calvez, V; Paredes, R; Pillay, D; Shafer, RW; Wensing, AM; Jacobsen, DM; Günthard, HF; Calvez, V; Paredes, R; Pillay, D; Shafer, RW; Wensing, AM; Jacobsen, DM; Richman, DD; - view fewer (2018) Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society-USA Panel. Clinical Infectious Diseases , Article ciy463. 10.1093/cid/ciy463 . (In press). Green open access

https://ift.tt/2NMKbOT

Editorial: Contexts and controversy

Joshi, H; (2018) Editorial: Contexts and controversy. Longitudinal and Life Course Studies , 9 (2) pp. 131-132. 10.14301/llcs.v9i2.516 . Green open access

https://ift.tt/2xThFAl

Lateral Proboscis (Elephant Tusk) with Orofacial Clefts: A Report of a Rare Case

Lateral proboscis is a rare congenital anomaly. Lateral proboscis is a rare craniofacial malformation characterized by a rudimentary tubular, nose-like structure occurring in association with a wide spectrum of other anomalies. We presented a seven-month-old girl's lateral proboscis, cleft lip, and palate. Proboscis was excised by an elliptical incision, and the cleft was repaired at the same surgery.

https://ift.tt/2xS4nUH

Coexistence of mucous membrane pemphigoid, vitiligo, and hypothyroidism: A second report of a new multiple autoimmune syndrome

Dermatologic Therapy, EarlyView.

https://ift.tt/2N5nrEO

Silicone breast implant associated fibromatosis

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Abstract

Extra-abdominal desmoid tumors, also known as aggressive or deep fibromatosis, are uncommon soft tissue tumors that rarely involve the breast. Although the exact etiology is unknown, the development of these tumors has been correlated with sites of previous trauma, surgery or in association with familial adenomatous polyposis. Clinically, breast fibromatosis is often mistaken for carcinoma but lacks metastatic potential. It is locally aggressive with high rates of recurrence. The treatment is primarily wide local excision with negative margins. Adjuvant treatments have been suggested and include radiotherapy, chemotherapy and hormonal therapy, however, there are no evidence-based treatment protocols to support their use. Here, we describe a case of fibromatosis that developed within the capsule around a silicone breast implant treated with surgical excision alone. The patient remains recurrence free at 3 months post-operative magnetic resonance imaging.

https://ift.tt/2OY3qBS

Nagashima‐type palmoplantar keratoderma and malignant melanoma in Japanese patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

https://ift.tt/2zxgE39

Emerging Insights into the Occupational Mycobiome

Abstract

Purpose of Review

The evolution of molecular-based methods over the last two decades has provided new approaches to identify and characterize fungal communities or "mycobiomes" at resolutions previously not possible using traditional hazard identification methods. The recent focus on fungal community assemblages within indoor environments has provided renewed insight into overlooked sources of fungal exposure. In occupational studies, internal transcribed spacer (ITS) region sequencing has recently been utilized in a variety of environments ranging from indoor office buildings to agricultural commodity and harvesting operations.

Recent Findings

Fungal communities identified in occupational environments have been primarily placed in the phylum Ascomycota and included classes typically identified using traditional fungal exposure methods such as the Eurotiomycetes, Dothideomycetes, Sordariomycetes, and Saccharomycetes. The phylum Basidiomycota has also been reported to be more prevalent than previously estimated and ITS region sequences have been primarily derived from the classes Agaricomycetes and Ustilaginomycetes. These studies have also resolved sequences placed in the Basidiomycota classes Tremellomycetes and Exobasidiomycetes that include environmental and endogenous yeast species.

Summary

These collective datasets have shown that occupational fungal exposures include a much broader diversity of fungi than once thought. Although the clinical implications for occupational allergy are an emerging field of research, establishing the mycobiome in occupational environments will be critical for future studies to determine the complete spectrum of worker exposures to fungal bioaerosols and their impact on worker health.

https://ift.tt/2xSCfky

Beware what lies beneath: a case of a gigantic cutaneous squamous cell carcinoma

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2zxfWTx

Herpes vegetans in a human immunodeficiency virus‐negative kidney transplant patient

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2Qas2aw

Widespread vegetating ulcers

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2zxxgrj

Risk factors associated with frontal fibrosing alopecia: a multicentre case–control study

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2QarRfm

Diabetic scleroedema successfully treated by topical hyaluronidase injection: efficacy of magnetic resonance imaging

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2zyGmEg

Successful treatment of PAPA syndrome with minocycline, dapsone, deflazacort and methotrexate: a cost‐effective therapy with a 2‐year follow‐up

Clinical and Experimental Dermatology, EarlyView.

https://ift.tt/2OfpJFH

Emerging Insights into the Occupational Mycobiome

Abstract

Purpose of Review

Recent Findings

Summary

https://ift.tt/2xSCfky

WhatsApp platforms in tropical public health resource‐poor settings

International Journal of Dermatology, EarlyView.

https://ift.tt/2xQxE2d

Corrigendum to “Plants as Useful Vectors to Reduce Environmental Toxic Arsenic Content”

https://ift.tt/2xTGoVl

Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5

Khathi, SP; Chandrasekaran, B; Karunanidhi, S; Tham, CL; Kozielski, F; Sayyad, N; Karpoormath, R; (2018) Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. Bioorganic and Medicinal Chemistry Letters , 28 (17) pp. 2930-2938. 10.1016/j.bmcl.2018.07.007 .

https://ift.tt/2OjhEzS

Impact of PI3K (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis

Laurent, P-A; Hechler, B; Solinhac, R; Ragab, A; Cabou, C; Anquetil, T; Severin, S; ... Gratacap, M-P; + view all Laurent, P-A; Hechler, B; Solinhac, R; Ragab, A; Cabou, C; Anquetil, T; Severin, S; Denis, CV; Mangin, PH; Vanhaesebroeck, B; Payrastre, B; Gratacap, M-P; - view fewer (2018) Impact of PI3K (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology , 38 (9) pp. 2041-2053. 10.1161/ATVBAHA.118.311410 .

https://ift.tt/2Q9llW8

Economic Evidence in Regulatory Disputes: Revisiting the Court-Regulatory Agency Relationship in the US and the UK

Mantzari, D; (2016) Economic Evidence in Regulatory Disputes: Revisiting the Court-Regulatory Agency Relationship in the US and the UK. Oxford Journal of Legal Studies , 36 (3) pp. 565-594. 10.1093/ojls/gqv035 . Green open access

https://ift.tt/2OjhFnq

Barriers and facilitators to shared decision making in child and youth mental health: clinician perspectives using the Theoretical Domains Framework

Hayes, D; Edbrooke-Childs, J; Town, R; Wolpert, M; Midgley, N; (2018) Barriers and facilitators to shared decision making in child and youth mental health: clinician perspectives using the Theoretical Domains Framework. European Child & Adolescent Psychiatry 10.1007/s00787-018-1230-0 . (In press). Green open access

https://ift.tt/2QapnxC

Bi-allelic mutations in MYL1 cause a severe congenital myopathy

Ravenscroft, G; Zaharieva, I; Bortolotti, CA; Lambrughi, M; Pignataro, M; Borsari, M; Sewry, CA; ... Muntoni, F; + view all Ravenscroft, G; Zaharieva, I; Bortolotti, CA; Lambrughi, M; Pignataro, M; Borsari, M; Sewry, CA; Phadke, R; Haliloglu, G; Ong, R; Goullée, H; Whyte, T; UK10K Consortium, ; Manzur, A; Talim, B; Kaya, U; Osborn, DP; Forrest, A; Laing, NG; Muntoni, F; - view fewer (2018) Bi-allelic mutations in MYL1 cause a severe congenital myopathy. Human Molecular Genetics 10.1093/hmg/ddy320 . (In press).

https://ift.tt/2OeGtwR

Is Pre-operation Social Connectedness Associated with Weight Loss up to 2 Years Post Bariatric Surgery?

Tymoszuk, U; Kumari, M; Pucci, A; Cheung, WH; Kirk, A; Tschiala, A; Carr-Rose, K; ... Batterham, RL; + view all Tymoszuk, U; Kumari, M; Pucci, A; Cheung, WH; Kirk, A; Tschiala, A; Carr-Rose, K; Kingett, H; Doyle, J; Jenkinson, A; Hashemi, M; Adamo, M; Elkalaawy, M; Stafford, M; Batterham, RL; - view fewer (2018) Is Pre-operation Social Connectedness Associated with Weight Loss up to 2 Years Post Bariatric Surgery? Obesity Surgery 10.1007/s11695-018-3378-6 . (In press).

https://ift.tt/2Q6hBVw

Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency

Kohn, DB; Hershfield, MS; Puck, JM; Aiuti, A; Blincoe, A; Gaspar, HB; Notarangelo, LD; Kohn, DB; Hershfield, MS; Puck, JM; Aiuti, A; Blincoe, A; Gaspar, HB; Notarangelo, LD; Grunebaum, E; - view fewer (2018) Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2018.08.024 . (In press).

https://ift.tt/2Oiwyq6

Correction: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy

Griffiths, PD; Rothwell, E; Raza, M; Wilmore, S; Doyle, T; Harber, M; O'Beirne, J; ... Emery, VC; + view all Griffiths, PD; Rothwell, E; Raza, M; Wilmore, S; Doyle, T; Harber, M; O'Beirne, J; Mackinnon, S; Jones, G; Thorburn, D; Mattes, F; Nebbia, G; Atabani, S; Smith, C; Stanton, A; Emery, VC; - view fewer (2017) Correction: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy. [Corrigendum]. PLOS ONo , 12 (9) , Article e0185298. 10.1371/journal.pone.0185298 . Green open access

https://ift.tt/2Q6gPYC

The co-construction of medical disposals in emergency medicine consultations

Stevenson, FA; Pelletier, C; Gibson, W; Park, S; Chrysikou, V; (2019) The co-construction of medical disposals in emergency medicine consultations. Social Science and Medicine (In press).

https://ift.tt/2OcKDFL

Subclinical Macular Changes and Disease Laterality in Pediatric Coats Disease Determined by Quantitative Optical Coherence Tomography Angiography

Schwartz, R; Sivaprasad, S; Macphee, R; Ibanez, P; Keane, PA; Michaelides, M; Wong, SC; (2018) Subclinical Macular Changes and Disease Laterality in Pediatric Coats Disease Determined by Quantitative Optical Coherence Tomography Angiography. Retina 10.1097/IAE.0000000000002322 . (In press). Green open access

https://ift.tt/2QbGmQe

Erratum to: Fruit and Vegetable Consumption and Frailty: A Systematic Review

Kojima, G; Avgerinou, C; Iliffe, S; Jivraj, S; Sekiguchi, K; Walters, K; (2018) Erratum to: Fruit and Vegetable Consumption and Frailty: A Systematic Review. [Corrigendum]. The journal of Nutrition, Health & Aging 10.1007/s12603-018-1074-9 . (In press). Green open access

https://ift.tt/2OcKwtP

Learning from Excellence: the 'Yaytix' programme

Chain, G; Marshall, E; Geddie, C; Joseph, S; Chain, B; Clark, C; (2018) Learning from Excellence: the 'Yaytix' programme. Scottish Medical Journal 10.1177/0036933018799605 . (In press). Green open access

https://ift.tt/2Q6guoO

Protocol for the insight study: a randomised controlled trial of single-dose tocilizumab in patients with depression and low-grade inflammation

Khandaker, GM; Oltean, BP; Kaser, M; Dibben, CRM; Ramana, R; Jadon, DR; Dantzer, R; ... Jones, PB; + view all Khandaker, GM; Oltean, BP; Kaser, M; Dibben, CRM; Ramana, R; Jadon, DR; Dantzer, R; Coles, AJ; Lewis, G; Jones, PB; - view fewer (2018) Protocol for the insight study: a randomised controlled trial of single-dose tocilizumab in patients with depression and low-grade inflammation. BMJ Open , 8 (9) , Article e025333. 10.1136/bmjopen-2018-025333 . Green open access

https://ift.tt/2OcKlyF

Editorial: Automating subcutaneous ICD screening and future sensing refinements

Lambiase, PD; (2018) Editorial: Automating subcutaneous ICD screening and future sensing refinements. [Editorial comment]. International Journal of Cardiology 10.1016/j.ijcard.2018.07.144 . (In press).

https://ift.tt/2QbJXO3

Precise time-matching in chimpanzee allogrooming does not occur after a short delay

Phelps, S; Ng, WL; Musolesi, M; Russell, Y; (2018) Precise time-matching in chimpanzee allogrooming does not occur after a short delay. PLoS ONE , 13 (9) , Article e0201810. 10.1371/journal.pone.0201810 . Green open access

https://ift.tt/2OeV9MB

Hypertension and consequent mortality risk in China

Stefler, D; Roever, L; (2018) Hypertension and consequent mortality risk in China. [Editorial comment]. Journal of Epidemiology and Community Health 10.1136/jech-2018-211430 . (In press). Green open access

https://ift.tt/2Qax0UF

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

Håkansson, I; Tisell, A; Cassel, P; Blennow, K; Zetterberg, H; Lundberg, P; Dahle, C; ... Ernerudh, J; + view all Håkansson, I; Tisell, A; Cassel, P; Blennow, K; Zetterberg, H; Lundberg, P; Dahle, C; Vrethem, M; Ernerudh, J; - view fewer (2018) Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis. Journal of Neuroinflammation , 15 (1) , Article 209. 10.1186/s12974-018-1249-7 . Green open access

https://ift.tt/2Ohv8fI

Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease

Lewczuk, P; Ermann, N; Andreasson, U; Schultheis, C; Podhorna, J; Spitzer, P; Maler, JM; ... Zetterberg, H; + view all Lewczuk, P; Ermann, N; Andreasson, U; Schultheis, C; Podhorna, J; Spitzer, P; Maler, JM; Kornhuber, J; Blennow, K; Zetterberg, H; - view fewer (2018) Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease. Alzheimer's Research & Therapy , 10 (1) , Article 71. 10.1186/s13195-018-0404-9 . Green open access

https://ift.tt/2Q6fVLI

Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment

Johansson, P; Almqvist, EG; Wallin, A; Johansson, J-O; Andreasson, U; Blennow, K; Zetterberg, H; Johansson, P; Almqvist, EG; Wallin, A; Johansson, J-O; Andreasson, U; Blennow, K; Zetterberg, H; Svensson, J; - view fewer (2017) Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment. PLOS ONE , 12 (5) , Article e0176760. 10.1371/journal.pone.0176760 . Green open access

https://ift.tt/2OdEoBs

Guideline-indicated treatments and diagnostics, GRACE risk score, and survival for non-ST elevation myocardial infarction

Hall, M; Bebb, OJ; Dondo, TB; Yan, AT; Goodman, SG; Bueno, H; Chew, DP; ... Gale, CP; + view all Hall, M; Bebb, OJ; Dondo, TB; Yan, AT; Goodman, SG; Bueno, H; Chew, DP; Brieger, D; Batin, PD; Farkouh, ME; Hemingway, H; Timmis, A; Fox, KAA; Gale, CP; - view fewer (2018) Guideline-indicated treatments and diagnostics, GRACE risk score, and survival for non-ST elevation myocardial infarction. European Heart Journal , Article ehy517. 10.1093/eurheartj/ehy517 . Green open access

https://ift.tt/2QbGmzr

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