Publication date: June 2018
Source:Epilepsy & Behavior, Volume 83
Author(s): David Baker, Fiona J.R. Eccles, Helen L. Caswell
ObjectivesThe aim of this review was to identify quantitative correlates, predictors, and outcomes of stigma in adults with epilepsy living in Western countries.MethodsTo identify relevant literature, four academic databases (PsycINFO, CINAHL, PubMed, and Scopus) were systematically searched using key terms related to stigma and epilepsy.ResultsThirty-three research papers reporting findings from 25 quantitative studies of correlates of stigma in epilepsy were identified. The findings suggest that stigma can be predicted by demographic, illness-related, and psychosocial factors, although associations were found to be highly culturally specific. Outcomes of stigma in people with epilepsy were replicated more consistently across cultures, and its impact was significant. Detrimental effects included both worse physical health, including less effective management of the condition, and reduced psychological well-being, including difficulties such as depression and anxiety.ImplicationsEducational initiatives and therapeutic interventions that aim to address stigma in people with epilepsy are recommended; however, these need to be culturally informed to ensure that they are valid and effective.
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Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Τρίτη 24 Απριλίου 2018
Correlates of stigma in adults with epilepsy: A systematic review of quantitative studies
Response to Cuttler et al. re: “Low-Dose Childhood Radiation Effects to the Thyroid Follow a Linear Dose–Response Trend and Persist Even 45+ Years After Exposure”
Thyroid, Ahead of Print.
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Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy
Viral Immunology, Ahead of Print.
https://ift.tt/2Fex6ok
Influenza Vaccination Protects Against Pandemic H1N1 Infection in Sickle Cell Disease Mice
Viral Immunology, Ahead of Print.
https://ift.tt/2Kc46RZ
Development of a patient‐centric food allergy research program: A model for action
Allergy, EarlyView.
https://ift.tt/2HXksx4
Genetic predisposition to obesity is associated with asthma in US Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos
Allergy, EarlyView.
https://ift.tt/2HY0TEP
Identification of CPE and GAIT elements in 3’UTR of macrophage migration inhibitory factor (MIF) involved in inflammatory response induced by LPS in Ciona robusta
Publication date: July 2018
Source:Molecular Immunology, Volume 99
Author(s): Aiti Vizzini, Maria Giovanna Parisi, Felicia Di Falco, Laura Cardinale, Matteo Cammarata, Vincenzo Arizza
Innate immune responses face infectious microorganisms by inducing inflammatory responses. Multiple genes within distinct functional categories are coordinately and temporally regulated by transcriptional 'on' and 'off' switches that account for the specificity of gene expression in response to external stimuli. Mechanisms that control transcriptional and post-transcriptional regulation are important in coordinating the initiation and resolution of inflammation. Macrophage migration inhibitory factor (MIF) is an important cytokine that, in Ciona robusta, is related to inflammatory response. It is well known that in C. robusta, formerly known as Ciona intestinalis, the pharynx is involved in the inflammatory reaction induced by lipopolysaccharide (LPS) injection in the body wall. Using this biological system, we describe the identification of two C. robusta MIFs (CrMIF1 and CrMIF2). The phylogenetic tree and modeling support a close relationship with vertebrate MIF family members. CrMIF1 and CrMIF2 possess two evolutionally conserved catalytic sites: a tautomerase and an oxidoreductase site with a conserved CXXC motif. Real-time PCR analysis shows a prompt expression induced by LPS inoculation in CrMIF1 and a late upregulation of CrMIF2 and in silico analyses of 3'UTR show a cis-acting GAIT element and a CPE element in 3'-UTR, which are not present in the 3'-UTR of CrMIF1, suggesting that different transcriptional and post-transcriptional control mechanisms are involved in the regulation of gene expression of MIF during inflammatory response in C. robusta.
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The evolving role of lymphatics in cancer metastasis
Rae H Farnsworth | Marc G Achen | Steven A Stacker
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Relationships Among C-Reactive Protein, Alanine Aminotransferase, and Metabolic Syndrome in Apparently Healthy Chinese Subjects
Metabolic Syndrome and Related Disorders, Ahead of Print.
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Gender Differences in the Effects of the Frequency of Physical Activity on the Incidence of Metabolic Syndrome: Results from a Middle-Aged Community Cohort in Taiwan
Metabolic Syndrome and Related Disorders, Ahead of Print.
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Can avocado oil strengthen my hair?
Oils play an important role in the health of a person's hair. Avocado oil may have specific benefits due to its vitamin and mineral composition. When the hair's natural oil balance is uneven, or the environment has damaged the hair, using oils on the scalp or hair may moisturize it and prevent further damage.
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Why EMS agencies should change their definition of intubation success
Sponsored by EMS PRO Jeffrey Jarvis, MD, EMS medical director for Williamson County (Texas) EMS, knew he was passionate about emergency medical services after his first semester at Texas A&M University. While going to school and working for Texas A&M EMS, he progressed through paramedicine and worked in a variety of roles. After 10 years in EMS, he went back to school to continue his EMS career ...
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Eczema complicated by allergic contact dermatitis to topical medications and excipients
In patients with eczema that is difficult to manage, it is important to consider the possibility that they are allergic to the topical medications or emollients being used to manage their skin disease. This group of patients may have allergic contact dermatitis (ACD) to topical corticosteroids (TCS), antibiotics, or the excipients and preservatives used in their topical medications or emollients being used for skin care. For this group of patients, topical corticosteroids or the excipients in their vehicle may actually worsen their underlying disease and are the focus of this article.
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Multi-dimensional analysis of oral cavity and oropharyngeal defects following cancer extirpation surgery, a cadaveric study
Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of...
https://ift.tt/2HqjTe4
Dealing with The Gimmie-Gimmies | Saying No To Your Child
I was at Schnucks the other day and witnessed a classic case of the "gimmie-gimmies." This child was young, but at the same time I'd say old enough to know better. He spied a toy that he just HAD to have. The mother told him "No, we're not buying any toys today." And yet he proceeded to grab the item. She made him put it back, and he started whining. She took his hand to lead him down the aisle, and he proceeded to break free and grab the item again. The mother attempted to distract him by asking him to help her find the bananas. But it was no use, he had his mind set on getting that toy. He eventually started yelling, crying, and stomping his feet. At one point, I heard him call her a "stupid mom." Ouch! Other customers started watching and staring. Some were maybe judging while others were probably just feeling sorry for her. The mother picked up her son (who was in the midst of kicking and screaming) and proceeded to the self-check-out line. A well-meaning employee came over and attempted to calm the child by asking him what was wrong and offering him a sticker. But, this child was beyond consolable and couldn't have cared less about a neon store sticker. The mother quickly paid for her groceries and then picked up her child to carry him out of the store. At that point, he started shrieking so loud, it was as if he were being kidnapped by a stranger.
I'm glad no one in that store knew my profession, because as a child psychologist, my child should be better behaved, right? Sigh. A moment of humility. I am that mother of the little boy screaming his head off in the middle of the grocery store and it was pretty embarrassing. I felt bad letting my child melt down in public when I could have stopped it – or even prevented it. I felt bad causing such a commotion. But, if I could go back – would I have handled things much differently? Nope. Although at the time I felt like a horrible mother, doing the right thing as a parent doesn't always lend itself to immediate rewards. But, in the long run, I do believe that not giving into the "gimmie-gimmies" is worth it.
Why You Should Say No to Your Child
- As parents it's a natural instinct to want to provide for our children, to give them what we can, and to enjoy seeing that smile on their face when they get a new toy. But, you can't get everything you want in life – when you want it (such as RIGHT NOW). It's a fact of life, so why not teach your child early on. Of course like anything else there's not a clearly defined line between providing your child with just the basic necessities and spoiling your child rotten. But, when your child resembles Veruca Salt from Willy Wonka, suffice it to say – you've given in too much. In the above grocery store situation, I believe that toy only cost $5. But that's a moot point because I don't want my son to think he can buy something every time we're at a store or grow up demanding "golden eggs."
- Keep in mind that giving into a tantrum is reinforcing your child to act in the exact same way the next time they are told no. It's a form of reinforcement – a variable ratio schedule of reinforcement to be exact (using Operant Conditioning lingo). In layman terms, this means that although you likely don't give in to every tantrum, just by giving in on one occasion, your child has inadvertently learned that 'throwing a fit' may very well get him what he wants. If you need evidence, just consider why people spend hours feeding quarters into a slot machine awaiting that small but real chance that they may win the jackpot!
- When you've said "no" to something, hold your ground. As my favorite Hootie and the Blowfish song goes, "Let her cry" (random throw-back to the 90's). Throwing a fit won't harm your child. Yes, it's not enjoyable watching your child melt down emotionally, scream and holler, stomp and kick, and who knows what else, but they will eventually learn.
Ways to Make Saying No Easier
- Distraction can sometimes be your best friend in a tantrum situation. But, don't be surprised if your child is too "stuck" (mentally fixated on that one thing alone) or is emotionally beyond the point of being able to focus on anything else. Also, beware of distractions that can reinforce their tantrum behavior (e.g., Oh poor child, do you want a free cookie?). Throwing a fit = earning a cookie. Not the best way to extinguish (put an end to) inappropriate behavior.
- It's okay to be a bad mom sometimes … or in my son's eyes a "stupid mom!" Did it hurt my feelings on some level – of course. But I know his name-calling was an impulsive, emotional reaction and not how he truly feels about me. And I'm guessing I'll probably be called much worse at some point when he develops a more sophisticated vocabulary. As a parent, sometimes you need thick skin.
- Who cares what other people think? This is a hard one, but sometimes you need to tune out everyone else in the grocery store to effectively deal with the "gimmie-gimmies." Sticking to your guns and saying no to your children sometimes equates to looking like a horrible mother (or a child abductor). But, try to remember that while embarrassing situations come and go, the positive behavior, values, and character you are instilling in your children will stay with them throughout their lives. Plus, most of us have been there at some point.
- So in the end, what should you do when you come across the "gimmie-gimmies?" Just say NO to your child, and don't you dare give in!
The post Dealing with The Gimmie-Gimmies | Saying No To Your Child appeared first on ChildrensMD.
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World's first penis and scrotum transplant complete
The first total penis and scrotum transplant has now been performed by a team of Johns Hopkins surgeons. The recipient, they say, 'is recovering well.'
https://ift.tt/2KcHCAv
KELCH F-BOX protein positively influences Arabidopsis seed germination by targeting PHYTOCHROME-INTERACTING FACTOR1 [Plant Biology]
Seeds employ sensory systems that assess various environmental cues over time to maximize the successful transition from embryo to seedling. Here we show that the Arabidopsis F-BOX protein COLD TEMPERATURE-GERMINATING (CTG)-10, identified by activation tagging, is a positive regulator of this process. When overexpressed (OE), CTG10 hastens aspects of seed...
https://ift.tt/2HPbMv5
Glucagon contributes to liver zonation [Physiology]
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal function. Wnt/β-catenin signaling controls metabolic zonation by activating genes in the perivenous hepatocytes, while suppressing genes in the periportal counterparts. We now demonstrate that glucagon opposes the actions of Wnt/β-catenin signaling on gene expression...
https://ift.tt/2HsyjdE
Correction for Kristensen et al., Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism [Correction]
MEDICAL SCIENCES Correction for "Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism," by David Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné,...
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Correction for Serr et al., miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity [Correction]
IMMUNOLOGY AND INFLAMMATION Correction for "miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity" by Isabelle Serr, Rainer W. Fürst, Verena B. Ott, Martin G. Scherm, Alexei Nikolaev, Füsun Gökmen, Stefanie Kälin, Stephanie Zillmer, Melanie Bunk, Benno Weigmann, Nicole Kunschke,...
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Correction for Kobayashi et al., B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells [Correction]
IMMUNOLOGY Correction for "B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells," by Yoshihisa Kobayashi, Arifumi Iwata, Kotaro Suzuki, Akira Suto, Saki Kawashima, Yukari Saito, Takayoshi Owada, Midori Kobayashi, Norihiko Watanabe, and Hiroshi Nakajima, which was first published March 11,...
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Correction for DuBose et al., Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts [Correction]
GENETICS Correction for "Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts," by Amanda J. DuBose, Stephen T. Lichtenstein, Noreen M. Petrash, Michael R. Erdos, Leslie B. Gordon, and Francis S. Collins, which was first published March 26, 2018; 10.1073/pnas.1802811115. The authors note that Fig. 6 appeared incorrectly. The corrected figure...
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Neddylation mediates ventricular chamber maturation through repression of Hippo signaling [Physiology]
During development, ventricular chamber maturation is a crucial step in the formation of a functionally competent postnatal heart. Defects in this process can lead to left ventricular noncompaction cardiomyopathy and heart failure. However, molecular mechanisms underlying ventricular chamber development remain incompletely understood. Neddylation is a posttranslational modification that attaches ubiquitin-like...
https://ift.tt/2HKQuik
Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man [Physiology]
Glucocorticoids (GCs) are secreted in an ultradian, pulsatile pattern that emerges from delays in the feedforward-feedback interaction between the anterior pituitary and adrenal glands. Dynamic oscillations of GCs are critical for normal cognitive and metabolic function in the rat and have been shown to modulate the pattern of GC-sensitive gene...
https://ift.tt/2JmfHMZ
Harmonics added to a flickering light can upset the balance between ON and OFF pathways to produce illusory colors [Neuroscience]
The neural signals generated by the light-sensitive photoreceptors in the human eye are substantially processed and recoded in the retina before being transmitted to the brain via the optic nerve. A key aspect of this recoding is the splitting of the signals within the two major cone-driven visual pathways into...
https://ift.tt/2HRdM5U
Human hydroxymethylbilane synthase: Molecular dynamics of the pyrrole chain elongation identifies step-specific residues that cause AIP [Medical Sciences]
Hydroxymethylbilane synthase (HMBS), the third enzyme in the heme biosynthetic pathway, catalyzes the head-to-tail condensation of four molecules of porphobilinogen (PBG) to form the linear tetrapyrrole 1-hydroxymethylbilane (HMB). Mutations in human HMBS (hHMBS) cause acute intermittent porphyria (AIP), an autosomal-dominant disorder characterized by life-threatening neurovisceral attacks. Although the 3D structure...
https://ift.tt/2JpG5FX
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression [Medical Sciences]
Colorectal cancer (CRC) is one of the most common tumor entities, which is causally linked to DNA repair defects and inflammatory bowel disease (IBD). Here, we studied the role of the DNA repair protein poly(ADP-ribose) polymerase-1 (PARP-1) in CRC. Tissue microarray analysis revealed PARP-1 overexpression in human CRC, correlating with...
https://ift.tt/2HLw34E
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation [Immunology and Inflammation]
Despite decades of research, mechanisms controlling T cell activation remain only partially understood, which hampers T cell-based immune cancer therapies. Here, we performed a genome-wide CRISPR screen to search for genes that regulate T cell activation. Our screen confirmed many of the known regulators in proximal T cell receptor signaling...
https://ift.tt/2HodGiR
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment [Immunology and Inflammation]
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism of resistance to cancer immunotherapy. We show that, in human lung squamous-cell carcinomas, exclusion of CD8 T...
https://ift.tt/2qVfsBI
Programmed self-assembly of peptide-maȷor histocompatibility complex for antigen-specific immune modulation [Immunology and Inflammation]
A technology to prime desired populations of T cells in the body—particularly those that possess low avidity against target antigen—would pave the way for the design of new types of vaccination for intractable infectious diseases or cancer. Here, we report such a technology based on positive feedback-driven, programmed self-assembly of...
https://ift.tt/2HodqjT
Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus [Immunology and Inflammation]
The amphibian Xenopus laevis is to date the only species outside of mammals where a MHC class I-like (MHC-like) restricted innate-like (i) T cell subset (iVα6 T cells) reminiscent of CD1d-restricted iNKT cells has been identified and functionally characterized. This provides an attractive in vivo model to study the biological...
https://ift.tt/2HJsQme
Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing [Genetics]
Epigenetic silencing can be mediated by various mechanisms, and many regulators remain to be identified. Here, we report a genome-wide siRNA screening to identify regulators essential for maintaining gene repression of a CMV promoter silenced by DNA methylation. We identified CSE1L (chromosome segregation 1 like) as an essential factor for...
https://ift.tt/2Jn92lE
Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia [Genetics]
Patagonia was the last region of the Americas reached by humans who entered the continent from Siberia ∼15,000–20,000 y ago. Despite recent genomic approaches to reconstruct the continental evolutionary history, regional characterization of ancient and modern genomes remains understudied. Exploring the genomic diversity within Patagonia is not just a valuable...
https://ift.tt/2HIYPmr
The plant hormone ethylene restricts Arabidopsis growth via the epidermis [Plant Biology]
The gaseous hormone ethylene plays a key role in plant growth and development, and it is a major regulator of stress responses. It inhibits vegetative growth by restricting cell elongation, mainly through cross-talk with auxins. However, it remains unknown whether ethylene controls growth throughout all plant tissues or whether its...
https://ift.tt/2JlMhyA
Nucleus-specific expression in the multinuclear mushroom-forming fungus Agaricus bisporus reveals different nuclear regulatory programs [Biophysics and Computational Biology]
Many fungi are polykaryotic, containing multiple nuclei per cell. In the case of heterokaryons, there are different nuclear types within a single cell. It is unknown what the different nuclear types contribute in terms of mRNA expression levels in fungal heterokaryons. Each cell of the mushroom Agaricus bisporus contains two...
https://ift.tt/2HIyqFz
Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues [Biochemistry]
Human metallocarboxypeptidase O (hCPO) is a recently discovered digestive enzyme localized to the apical membrane of intestinal epithelial cells. Unlike pancreatic metallocarboxypeptidases, hCPO is glycosylated and produced as an active enzyme with distinctive substrate specificity toward C-terminal (C-t) acidic residues. Here we present the crystal structure of hCPO at 1.85-Å...
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Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data
Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This stud...
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Multi-dimensional analysis of oral cavity and oropharyngeal defects following cancer extirpation surgery, a cadaveric study
Abstract
Background
Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of our study were: 1) to improve the understanding of the two- and three-dimensional nature of oral cavity and oropharyngeal defects following oncological resection and 2) to assess the geometric dimensions and the shapes of fasciocutaneous free flaps and locoregional tissue flaps required for reconstruction of these defects.
Methods
This study was an anatomic cadaveric study which involved creating defects in the oral cavity and oropharynx in two cadaveric specimens. Specifically, partial and total glossectomies, floor of mouth excisions, and base of tongue excisions were carried out. These subsites were subsequently geometrically analyzed and their volumes measured. The two-dimensional (2D) assessment of these three-dimensional (3D) structures included measures of surface area and assessment of tissue contours and shapes.
Results
The resected specimens all demonstrated unique dimensional geometry for the various anatomic sites. Using 2D analysis, hemiglossectomy defects revealed right triangle geometry, whereas total glossectomy geometry was a square. Finally, the base of tongue defects exhibited a trapezoid shape.
Conclusions
Customizing the geometry and dimensions of fasciocutaneous free flaps so that they are specific to the confronted head and neck defects will likely result in better functional and cosmetic outcomes.
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How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries
Stuart, RM; Grobicki, L; Haghparast-Bidgoli, H; Panovska-Griffiths, J; Skordis, J; Keiser, O; Estill, J; ... Wilson, DP; + view all Stuart, RM; Grobicki, L; Haghparast-Bidgoli, H; Panovska-Griffiths, J; Skordis, J; Keiser, O; Estill, J; Baranczuk, Z; Kelly, SL; Reporter, I; Kedziora, DJ; Shattock, AJ; Petravic, J; Hussain, SA; Grantham, KL; Gray, RT; Yap, XF; Martin-Hughes, R; Benedikt, CJ; Fraser-Hurt, N; Masaki, E; Wilson, DJ; Gorgens, M; Mziray, E; Cheikh, N; Shubber, Z; Kerr, CC; Wilson, DP; - view fewer (2018) How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries. Journal of the International AIDS Society , 21 (4) , Article e25097. 10.1002/jia2.25097 . Green open access
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Platelet function is modified by common sequence variation in megakaryocyte super enhancers
Petersen, R; Lambourne, JJ; Javierre, BM; Grassi, L; Kreuzhuber, R; Ruklisa, D; Rosa, IM; ... Frontini, M; + view all Petersen, R; Lambourne, JJ; Javierre, BM; Grassi, L; Kreuzhuber, R; Ruklisa, D; Rosa, IM; Tomé, AR; Elding, H; van Geffen, JP; Jiang, T; Farrow, S; Cairns, J; Al-Subaie, AM; Ashford, S; Attwood, A; Batista, J; Bouman, H; Burden, F; Choudry, FA; Clarke, L; Flicek, P; Garner, SF; Haimel, M; Kempster, C; Ladopoulos, V; Lenaerts, A-S; Materek, PM; McKinney, H; Meacham, S; Mead, D; Nagy, M; Penkett, CJ; Rendon, A; Seyres, D; Sun, B; Tuna, S; van der Weide, M-E; Wingett, SW; Martens, JH; Stegle, O; Richardson, S; Vallier, L; Roberts, DJ; Freson, K; Wernisch, L; Stunnenberg, HG; Danesh, J; Fraser, P; Soranzo, N; Butterworth, AS; Heemskerk, JW; Turro, E; Spivakov, M; Ouwehand, WH; Astle, WJ; Downes, K; Kostadima, M; Frontini, M; - view fewer (2017) Platelet function is modified by common sequence variation in megakaryocyte super enhancers. Nature Communications , 8 , Article 16058. 10.1038/ncomms16058 . Green open access
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Primary photodynamic therapy with verteporfin for pigmented posterior pole cT1a choroidal melanoma: a 3-year retrospective analysis
Fabian, ID; Stacey, AW; Harby, LA; Arora, AK; Sagoo, MS; Cohen, VML; (2018) Primary photodynamic therapy with verteporfin for pigmented posterior pole cT1a choroidal melanoma: a 3-year retrospective analysis. British Journal of Ophthalmology 10.1136/bjophthalmol-2017-311747 . (In press). Green open access
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Preoperative Red Cell Distribution Width and 30-day mortality in older patients undergoing non-cardiac surgery: a retrospective cohort observational study
Abdullah, HR; Sim, YE; Sim, YT; Ang, AL; Chan, YH; Richards, T; Ong, BC; (2018) Preoperative Red Cell Distribution Width and 30-day mortality in older patients undergoing non-cardiac surgery: a retrospective cohort observational study. Scientific Reports , 8 , Article 6226. 10.1038/s41598-018-24556-z . Green open access
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The production and politics of urban knowledge: contesting transport in Auckland, New Zealand
McArthur, J; (2018) The production and politics of urban knowledge: contesting transport in Auckland, New Zealand. Urban Policy and Research (In press).
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Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study
Bisdas, S; Shen, H; Thust, S; Katsaros, V; Stranjalis, G; Boskos, C; Brandner, S; Bisdas, S; Shen, H; Thust, S; Katsaros, V; Stranjalis, G; Boskos, C; Brandner, S; Zhang, J; - view fewer (2018) Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study. Scientific Reports , 8 , Article 6108. 10.1038/s41598-018-24438-4 . Green open access
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MagicFace: Stepping into Character through an Augmented Reality Mirror
Javornik, A; Rogers, Y; Gander, D; Moutinho, A; (2017) MagicFace: Stepping into Character through an Augmented Reality Mirror. In: CHI '17 Proceedings of the 2017 CHI Conference on Human Factors in Computing Systems. (pp. pp. 4838-4849). Association for Computing Machinery (ACM): New York, NY, USA. Green open access
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Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 x 2 factorial, double-blind, randomised controlled trial
Rajendram, R; Taylor, PN; Wilson, VJ; Harris, N; Morris, OC; Tomlinson, M; Yarrow, S; ... Dayan, CM; + view all Rajendram, R; Taylor, PN; Wilson, VJ; Harris, N; Morris, OC; Tomlinson, M; Yarrow, S; Garrott, H; Herbert, HM; Dick, AD; Cook, A; Gattamaneni, R; Jain, R; Olver, J; Hurel, SJ; Bremner, F; Drummond, SR; Kemp, E; Ritchie, DM; Rumsey, N; Morris, D; Lane, C; Palaniappan, N; Li, C; Pell, J; Hills, R; Ezra, DG; Potts, MJ; Jackson, S; Rose, GE; Plowman, N; Bunce, C; Uddin, JM; Lee, RWJ; Dayan, CM; - view fewer (2018) Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 x 2 factorial, double-blind, randomised controlled trial. The Lancet Diabetes & Endocrinology , 6 (4) pp. 299-309. 10.1016/S2213-8587(18)30021-4 .
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Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data
Stirrup, OT; Dunn, DT; Tostevin, A; Sabin, CA; Pozniak, A; Asboe, D; Cox, A; ... UK Collaborative HIV Cohort, .; + view all Stirrup, OT; Dunn, DT; Tostevin, A; Sabin, CA; Pozniak, A; Asboe, D; Cox, A; Orkin, C; Martin, F; Cane, P; UK HIV Drug Resistance Database, .; UK Collaborative HIV Cohort, .; - view fewer (2018) Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data. AIDS Research and Therapy , 15 , Article 11. 10.1186/s12981-018-0198-7 . Green open access
https://ift.tt/2vCc8QO
Applications of Microalgal Biotechnology for Disease Control in Aquaculture
Charoonnart, P; Purton, S; Saksmerprome, V; (2018) Applications of Microalgal Biotechnology for Disease Control in Aquaculture. Biology , 7 (2) , Article 24. 10.3390/biology7020024 . Green open access
https://ift.tt/2HHczhJ
ADI-PEG 20 Plus Best Supportive Care versus Placebo Plus Best Supportive Care in Patients with Advanced Hepatocellular Carcinoma
Abou-Alfa, G; Qin, S; Ryoo, B-Y; Lu, S-N; Yen, C-J; Feng, Y-H; Lim, HY; ... Chen, L-T; + view all Abou-Alfa, G; Qin, S; Ryoo, B-Y; Lu, S-N; Yen, C-J; Feng, Y-H; Lim, HY; Izzo, F; Colombo, M; Sarker, D; Bolondi, L; Vaccaro, G; Harris, WP; Chen, Z; Hubner, RA; Meyer, T; Sun, W; Harding, JJ; Hollywood, EM; Ma, J; Wan, PJ; Ly, M; Bomalaski, J; Johnston, A; Lin, C-C; Chao, Y; Chen, L-T; - view fewer (2018) ADI-PEG 20 Plus Best Supportive Care versus Placebo Plus Best Supportive Care in Patients with Advanced Hepatocellular Carcinoma. Annals of Oncology 10.1093/annonc/mdy101 . (In press).
https://ift.tt/2vCbPWa
Characterization of Chlorella sorokiniana, UTEX 1230
Lizzul, AM; Lekuona-Amundarain, A; Purton, S; Campos, LC; (2018) Characterization of Chlorella sorokiniana, UTEX 1230. Biology , 7 (2) , Article 25. 10.3390/biology7020025 . Green open access
https://ift.tt/2HI5xcB
A methodology to extract outcomes from routine healthcare data for patients with locally advanced non-small cell lung cancer
Wong, S-L; Ricketts, K; Royle, G; Williams, M; Mendes, R; (2018) A methodology to extract outcomes from routine healthcare data for patients with locally advanced non-small cell lung cancer. BMC Health Services Research , 18 , Article 278. 10.1186/s12913-018-3029-6 . Green open access
https://ift.tt/2vH04h7
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Maffioletti, SM; Sarcar, S; Henderson, ABH; Mannhardt, I; Pinton, L; Moyle, LA; Steele-Stallard, H; ... Tedesco, FS; + view all Maffioletti, SM; Sarcar, S; Henderson, ABH; Mannhardt, I; Pinton, L; Moyle, LA; Steele-Stallard, H; Cappellari, O; Wells, KE; Ferrari, G; Mitchell, JS; Tyzack, GE; Kotiadis, VN; Khedr, M; Ragazzi, M; Wang, W; Duchen, MR; Patani, R; Zammit, PS; Wells, DJ; Eschenhagen, T; Tedesco, FS; - view fewer (2018) Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports , 23 (3) pp. 899-908. 10.1016/j.celrep.2018.03.091 . Green open access
https://ift.tt/2qUS3QS
Socioeconomic disadvantage across the life-course and oral health in older age: findings from a longitudinal study of older British men
Ramsay, S; Papachristou, E; Watt, RG; Lennon, LT; Papacosta, O; Whincup, PH; Wannamethee, SG; (2018) Socioeconomic disadvantage across the life-course and oral health in older age: findings from a longitudinal study of older British men. Journal of Public Health (In press).
https://ift.tt/2vLCEaE
Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster
Weinrich, TW; Coyne, A; Salt, TE; Hogg, C; Jeffery, G; (2017) Improving mitochondrial function significantly reduces metabolic, visual, motor and cognitive decline in aged Drosophila melanogaster. Neurobiology of Aging , 60 pp. 34-43. 10.1016/j.neurobiolaging.2017.08.016 .
https://ift.tt/2qURQx4
[18F]Florbetaben PET-CT confirms AL amyloidosis in a patient with Waldenström's Macroglobulinaemia
Fox, TA; Lunn, M; Wechalekar, A; Bomanji, J; Wan, S; D'Sa, S; (2018) [18F]Florbetaben PET-CT confirms AL amyloidosis in a patient with Waldenström's Macroglobulinaemia. Haematologica 10.3324/haematol.2017.184515 . (In press). Green open access
https://ift.tt/2vPLeoX
Analyzing materials in the microscopes: From the Sorby thin sections up to the non-destructive large chambers
Garcia-Guinea, J; Garrido, F; Lopez-Arce, P; Tormo, L; Jorge, A; Furio, M; Paradela, C; (2016) Analyzing materials in the microscopes: From the Sorby thin sections up to the non-destructive large chambers. In: Al-Kamli, A and Can, N and Souadi, GO and Fadhali, M and Mahdy, A and Mahgoub, M, (eds.) Proceedings of the Fifth Saudi International Meeting on Frontiers of Physics (SIMFP2016). (pp. 020002:1-020002:8). American Institute of Physics (AIP) Green open access
https://ift.tt/2HLpA9W
Real-time Vision-based Stiffness Mapping
Faragasso, A; Bimbo, J; Stilli, A; Wurdemann, HA; Althoefer, K; Asama, H; (2018) Real-time Vision-based Stiffness Mapping. Physical Sensors (In press).
https://ift.tt/2vJwvM2
Seeds of Life in Space (SOLIS). III. Zooming Into the Methanol Peak of the Prestellar Core L1544
Punanova, A; Caselli, P; Feng, S; Chacon-Tanarro, A; Ceccarelli, C; Neri, R; Fontani, F; ... Ugliengo, P; + view all Punanova, A; Caselli, P; Feng, S; Chacon-Tanarro, A; Ceccarelli, C; Neri, R; Fontani, F; Jimenez-Serra, I; Vastel, C; Bizzocchi, L; Pon, A; Vasyunin, AI; Spezzano, S; Hily-Blant, P; Testi, L; Viti, S; Yamamoto, S; Alves, F; Bachiller, R; Balucani, N; Bianchi, E; Bottinelli, S; Caux, E; Choudhury, R; Codella, C; Dulieu, F; Favre, C; Holdship, J; Al-Edhari, AJ; Kahane, C; Laas, J; LeFloch, B; Lopez-Sepulcre, A; Ospina-Zamudio, J; Oya, Y; Pineda, JE; Podio, L; Quenard, D; Rimola, A; Sakai, N; Sims, IR; Taquet, V; Theule, P; Ugliengo, P; - view fewer (2018) Seeds of Life in Space (SOLIS). III. Zooming Into the Methanol Peak of the Prestellar Core L1544. The Astrophysical Journal , 855 (2) , Article 112. 10.3847/1538-4357/aaad09 . Green open access
https://ift.tt/2HLpijm
PaRTNer: Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer A Pilot, Survey Based Study
Intervention: Other: Demographics questionnaires and the FACT HN questionnaire
Sponsor: Duke University
Not yet recruiting
https://ift.tt/2HYxmuY
Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models
https://ift.tt/2KaEh4B
Advances on CD8+ Tregs and their potential in transplantation
https://ift.tt/2KaEc0N
Long-Term Outcomes of Kidney Transplantation in Fabry Disease
https://ift.tt/2Jo4sDZ
The Large Enriched Germanium Experiment for Neutrinoless Double Beta Decay (LEGEND)
Abgrall, N; Abramov, A; Abrosimov, N; Abt, I; Agostini, M; Agartioglu, M; Ajjaq, A; ... Zuzel, G; + view all Abgrall, N; Abramov, A; Abrosimov, N; Abt, I; Agostini, M; Agartioglu, M; Ajjaq, A; Alvis, SI; Avignone, FT; Bai, X; Balata, M; Barabanov, I; Barabash, AS; Barton, PJ; Baudis, L; Bezrukov, L; Bode, T; Bolozdynya, A; Borowicz, D; Boston, A; Boston, H; Boyd, STP; Breier, R; Brudanin, V; Brugnera, R; Busch, M; Buuck, M; Caldwell, A; Caldwell, TS; Camellato, T; Carpenter, M; Cattadori, C; Cederkall, J; Chan, Y-D; Chen, S; Chernogorov, A; Christofferson, CD; Chu, P-H; Cooper, RJ; Cuesta, C; Demidova, EV; Deng, Z; Deniz, M; Detwiler, JA; Di Marco, N; Domula, A; Du, Q; Efremenko, Y; Egorov, V; Elliott, SR; Fields, D; Fischer, F; Galindo-Uribarri, A; Gangapshev, A; Garfagnini, A; Gilliss, T; Giordano, M; Giovanetti, GK; Gold, M; Golubev, P; Gooch, C; Grabmayr, P; Green, MP; Gruszko, J; Guinn, IS; Guiseppe, VE; Gurentsov, V; Gurov, Y; Gusev, K; Hakenmueller, J; Harkness-Brennan, L; Harvey, ZR; Haufe, CR; Hauertmann, L; Heglund, D; Hehn, L; Heinz, A; Hiller, R; Hinton, J; Hodak, R; Hofmann, W; Howard, S; Howe, MA; Hult, M; Inzhechik, LV; 'Cs 'Athy, JJ; Janssens, R; skovsk'y, MJ; Jochum, J; Johansson, HT; Judson, D; Junker, M; Kaizer, J; Kang, K; Kazalov, V; Kermadic, Y; Kiessling, F; Kirsch, A; Kish, A; Klimenko, A; Knopfle, KT; Kochetov, O; Konovalov, SI; Kontul, I; Kornoukhov, VN; Kraetzschmar, T; Kroninger, K; Kumar, A; Kuzminov, VV; Lang, K; Laubenstein, M; Lazzaro, A; Li, YL; Li, Y-Y; Li, HB; Lin, ST; Lindner, M; Lippi, I; Liu, SK; Liu, X; Liu, J; Loomba, D; Lubashevskiy, A; Lubsandorzhiev, B; Lutter, G; Ma, H; Majorovits, B; Mamedov, F; Martin, RD; Massarczyk, R; Matthews, JAJ; McFadden, N; Mei, D-M; Mei, H; Meijer, SJ; Mengoni, D; Mertens, S; Miller, W; Miloradovic, M; Mingazheva, R; Misiaszek, M; Moseev, P; Myslik, J; Nemchenok, I; Nilsson, T; Nolan, P; O'Shaughnessy, C; Othman, G; Panas, K; Pandola, L; Papp, L; Pelczar, K; Peterson, D; Pettus, W; Poon, AWP; Povinec, PP; Pullia, A; Quintana, XC; Radford, DC; Rager, J; Ransom, C; Recchia, F; Reine, AL; Riboldi, S; Rielage, K; Rozov, S; Rouf, NW; Rukhadze, E; Rumyantseva, N; Saakyan, R; Sala, E; Salamida, F; Sandukovsky, V; Savard, G; Schonert, S; Schutz, A-K; Schulz, O; Schuster, M; Schwingenheuer, B; Selivanenko, O; Sevda, B; Shanks, B; Shevchik, E; Shirchenko, M; Simkovic, F; Singh, L; Singh, V; Skorokhvatov, M; Smolek, K; Smolnikov, A; Sonay, A; Spavorova, M; Stekl, I; Stukov, D; Tedeschi, D; Thompson, J; Van Wechel, T; Varner, RL; Vasenko, AA; Vasilyev, S; Veresnikova, A; Vetter, K; von Sturm, K; Vorren, K; Wagner, M; Wang, G-J; Waters, D; Wei, W-Z; Wester, T; White, BR; Wiesinger, C; Wilkerson, JF; Willers, M; Wiseman, C; Wojcik, M; Wong, HT; Wyenberg, J; Xu, W; Yakushev, E; Yang, G; Yu, C-H; Yue, Q; Yumatov, V; Zeman, J; Zeng, Z; Zhitnikov, I; Zhu, B; Zinatulina, D; Zschocke, A; Zsigmond, AJ; Zuber, K; Zuzel, G; - view fewer (2017) The Large Enriched Germanium Experiment for Neutrinoless Double Beta Decay (LEGEND). In: Civitarese, O and Stekl, I and Suhonen, J, (eds.) Workshop On Calculation Of Double-Beta-Decay Matrix Elements. (pp. 020027:1-020027:6). American Institute of Physics (AIP)
https://ift.tt/2KbjPAP
Transcend: Detecting Concept Drift in Malware Classification Models
Jordaney, R; Sharad, K; Dash, SK; Wang, Z; Papini, D; Nouretdinov, I; Cavallaro, L; (2017) Transcend: Detecting Concept Drift in Malware Classification Models. In: Proceedings of the 26th USENIX Security Symposium. (pp. pp. 625-642). USENIX Association: Vancouver, Canada. Green open access
https://ift.tt/2JkIjWY
Applications of magnetic nanoparticles in biomedicine: the story so far
Pankhurst, Q; Jones, S; Dobson, J; (2016) Applications of magnetic nanoparticles in biomedicine: the story so far. Journal of Physics D: Applied Physics , 49 (50) , Article 501002. 10.1088/0022-3727/49/50/501002 . Green open access
https://ift.tt/2K9mXgs
Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068
Fearon, E; Wiggins, RD; Pettifor, AE; MacPhail, C; Kahn, K; Selin, A; Gómez-Olivé, FX; ... Hargreaves, JR; + view all Fearon, E; Wiggins, RD; Pettifor, AE; MacPhail, C; Kahn, K; Selin, A; Gómez-Olivé, FX; Delany-Moretlwe, S; Piwowar-Manning, E; Laeyendecker, O; Hargreaves, JR; - view fewer (2017) Associations between friendship characteristics and HIV and HSV-2 status amongst young South African women in HPTN-068. Journal of the International AIDS Society , 20 (4) , Article e25029. 10.1002/jia2.25029 . Green open access
https://ift.tt/2JlNRQV
Inequity and Excellence in Academic Performance: Evidence From 27 Countries
Jerrim, JP; (2018) Inequity and Excellence in Academic Performance: Evidence From 27 Countries. American Educational Research Journal 10.3102/0002831218760213 . (In press). Green open access
https://ift.tt/2K8x5pX
Analysing shared competences in EU external action: the case for a politico-legal framework
Kamphof, R.; Wessel, R.; (2018) Analysing shared competences in EU external action: the case for a politico-legal framework. Europe and the World: A law review , 2 (2) pp. 38-64. 10.14324/111.444.ewlj.2018.02 . Green open access
https://ift.tt/2JlNLZz
Sporadic sampling, not climatic forcing, drives observed early hominin diversity
Maxwell, SJ; Hopley, PJ; Upchurch, P; Soligo, C; (2018) Sporadic sampling, not climatic forcing, drives observed early hominin diversity. Proceedings of the National Academy of Sciences 10.1073/pnas.1721538115 . (In press). Green open access
https://ift.tt/2K8weFL
Europol’s international cooperation between ‘past present’ and ‘present future’: reshaping the external dimension of EU police cooperation
Coman-Kund, F.; (2018) Europol's international cooperation between 'past present' and 'present future': reshaping the external dimension of EU police cooperation. Europe and the World: A law review , 2 (1) pp. 1-37. 10.14324/111.444.ewlj.2018.01 . Green open access
https://ift.tt/2JkEX6i
Disease evolution and response to rapamycin in Activated Phosphoinositide 3-Kinase delta syndrome: the european society for immunodeficiencies-Activated Phosphoinositide 3-Kinase d syndrome registry
Maccari, ME; Abolhassani, H; Aghamohammadi, A; Aiuti, A; Aleinikova, O; Bangs, C; Baris, S; ... Ehl, S; + view all Maccari, ME; Abolhassani, H; Aghamohammadi, A; Aiuti, A; Aleinikova, O; Bangs, C; Baris, S; Barzaghi, F; Baxendale, H; Buckland, M; Burns, SO; Cancrini, C; Cant, A; Cathebras, P; Cavazzana, M; Chandra, A; Conti, F; Coulter, T; Devlin, LA; Edgar, JDM; Faust, S; Fischer, A; Prat, MG; Hammarstrom, L; Heeg, M; Jolles, S; Karakoc-Aydiner, E; Kindle, G; Kiykim, A; Kumararatne, D; Grimbacher, B; Longhurst, H; Mahlaoui, N; Milota, T; Moreira, F; Moshous, D; Mukhina, A; Neth, O; Neven, B; Nieters, A; Olbrich, P; Ozen, A; Schmid, JP; Picard, C; Prader, S; Rae, W; Reichenbach, J; Rusch, S; Savic, S; Scarselli, A; Scheible, R; Sediva, A; Sharapova, SO; Shcherbina, A; Slatter, M; Soler-Palacin, P; Stanislas, A; Suarez, F; Tucci, F; Uhlmann, A; van Montfrans, J; Warnatz, K; Williams, AP; Wood, P; Kracker, S; Condliffe, AM; Ehl, S; - view fewer (2018) Disease evolution and response to rapamycin in Activated Phosphoinositide 3-Kinase delta syndrome: the european society for immunodeficiencies-Activated Phosphoinositide 3-Kinase d syndrome registry. Frontiers in Immunology , 9 , Article 543. 10.3389/fimmu.2018.00543 . Green open access
https://ift.tt/2K9j77a
Organization of area hV5/MT+ in subjects with homonymous visual field defects.
Papanikolaou, A; Keliris, GA; Papageorgiou, TD; Schiefer, U; Logothetis, NK; Smirnakis, SM; (2018) Organization of area hV5/MT+ in subjects with homonymous visual field defects. Neuroimage 10.1016/j.neuroimage.2018.03.062 . (In press).
https://ift.tt/2FcG7hP
Comparison of ophthalmic training in 6 English-speaking countries
Fahim, AT; Simunovic, MP; Mammo, Z; Mitry, D; Pakzad-Vaezi, K; Bradley, P; Mahroo, OA; (2016) Comparison of ophthalmic training in 6 English-speaking countries. Canadian Journal of Ophthalmology / Journal Canadien d'Ophtalmologie , 51 (3) pp. 212-218. 10.1016/j.jcjo.2016.04.018 . Green open access
https://ift.tt/2K8rZd8
Social Housing as a State-Funded Mega Project: A Case Study From Saudi Arabia
Kyriazis, A.; Balasis, E.; Patsavos, N.; (2018) Social Housing as a State-Funded Mega Project: A Case Study From Saudi Arabia. Architecture_media_politics_society , 13 (3) pp. 1-16. 10.14324/111.444.amps.2018v13i3.001 . Green open access
https://ift.tt/2Febvwe
Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor
Stefan, CJ; (2018) Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America 10.1073/pnas.1722517115 . (In press). Green open access
https://ift.tt/2K9j5MA
Dosing of ceftriaxone and metronidazole for children with severe acute malnutrition.
Standing, JF; Ongas, MO; Ogwang, C; Kagwanja, N; Murunga, S; Mwaringa, S; Ali, R; ... FLACSAM-PK Study Group, ; + view all Standing, JF; Ongas, MO; Ogwang, C; Kagwanja, N; Murunga, S; Mwaringa, S; Ali, R; Mturi, N; Timbwa, M; Manyasi, C; Mwalekwa, L; Bandika, VL; Ogutu, B; Waichungo, J; Kipper, K; Berkley, JA; FLACSAM-PK Study Group, ; - view fewer (2018) Dosing of ceftriaxone and metronidazole for children with severe acute malnutrition. Clin Pharmacol Ther 10.1002/cpt.1078 . (In press). Green open access
https://ift.tt/2FcNA0j
Free/Congested Two-Phase Model from Weak Solutions to Multi-Dimensional Compressible Navier-Stokes Equations
Perrin, C; Zatorska, E; (2015) Free/Congested Two-Phase Model from Weak Solutions to Multi-Dimensional Compressible Navier-Stokes Equations. Communications in Partial Differential Equations , 40 (8) pp. 1558-1589. 10.1080/03605302.2015.1014560 . Green open access
https://ift.tt/2KaBYif
Improving outcomes in congenital cataract
Solebo, AL; Hammond, CJ; Rahi, JS; (2018) Improving outcomes in congenital cataract. [Letter]. Nature , 556 (7699) E1-E2. 10.1038/nature26148 .
https://ift.tt/2FcpLFK
Pseudoaneurysm of the internal maxillary artery secondary to subcondylar fracture: case report and literature review
https://ift.tt/2vFcOVI
Sclerosing encapsulating peritonitis presenting as acute-on-chronic small-bowel obstruction in a patient with history of peritoneal carcinomatosis
https://ift.tt/2HGTg86
Over-the-scope clip (OTSC®) closure of a recto-acetabular fistula
https://ift.tt/2vEEhXr
Norman Theeck Makes a Comeback from Invasive Fungal Rhinosinusitis
Sixty-six-year-old Norman Theeck is a rarity. A long-term survivor after treatment for invasive fungal rhinosinusitis, he beat the slim odds... Read the full article...https://ift.tt/2HmAMue
Dr. Douglas Stanley Joins UTHealth and Memorial Hermann
Douglas Stanley, MD, has joined the Department of Otorhinolaryngology-Head and Neck Surgery at McGovern Medical School at UTHealth and the... Read the full article...https://ift.tt/2qVAxey
Audiology Open House a Success
The Audiology team at UT Physicians Otorhinolaryngology-Texas Medical Center held a well-attended, day-long open house for individuals in the community... Read the full article...https://ift.tt/2Hn8ksd
Editorial Board
Publication date: March 2018
Source:Annales de Dermatologie et de Vénéréologie, Volume 145, Supplement 3
https://ift.tt/2HLtG1L
Éditorial
Publication date: March 2018
Source:Annales de Dermatologie et de Vénéréologie, Volume 145, Supplement 3
Author(s): B. Cribier
https://ift.tt/2vM81C2
Negative myoclonus secondary to paroxetine intake
Outside the context of overdose and serotonin syndrome, seizures and myoclonic movements attributed to selective serotonin reuptake inhibitors (SSRIs) are rare and poorly documented. We present a 77-year-old man, with no history of epilepsy, presenting in the emergency department with whole body jerks since that morning. Two days earlier, due to a prescription mistake, he was started on paroxetine 20 mg instead of his usual fluoxetine 20 mg. The patient's electroencephalogram (EEG), performed in the emergency department, revealed a bilateral synchronous parieto-occipital fast spike activity pattern, which correlated consistently with negative myoclonus. Two days after stopping paroxetine, the patient presented no seizures and no abnormalities in the EEG. We present an EEG documented case of drug-induced seizures, with a bilateral parieto-occipital pattern, secondary to paroxetine intake. A hyperexcitability of the primary somatosensory cortex inhibiting primary motor cortex output could explain the electroclinical correlation.
https://ift.tt/2qTpHGK
Immune-mediated necrotising myopathy: a rare cause of hyperCKaemia
Immune-mediated necrotising myopathy (IMNM) is a type of inflammatory myopathy characterised by acute or subacute severe proximal muscle weakness, significantly elevated creatine kinase levels, and prominent myofibre necrosis and regeneration with little or no inflammation. A subtype of IMNM identified by anti-HMG-CoA reductase (HMGCR)antibodies has been shown to be associated with statin exposure. Treatment of IMNM consists of immunosuppression with steroids, steroid-sparing agents, intravenous immune globulin and/or biologics. We present here a case of anti-HMCGR-associated IMNM and review the pathophysiology, diagnosis and treatment to increase physician awareness of this rare and debilitating condition.
https://ift.tt/2vIGeSQ
A brain populated with space-occupying lesions: identifying the culprit
This is a case of an 8-year-old girl who was previously healthy and presented with unresponsiveness on a background of fever that resolved within 2 days of onset. History was significant for recurrent dental abscesses requiring drainage. Imaging revealed what was unexpected: a brain overloaded with multiple space-occupying lesions and diffuse oedema. The patient was started on mannitol and dexamethasone in addition to antimicrobials. Her condition improved dramatically within few days. Multiple aspiration procedures were performed later and she recovered fully with minor deficits.
https://ift.tt/2qUqCqm
Demonstration of entry tear and disrupted intima in asymptomatic chronic thrombosed type B dissection with non-obstructive angioscopy
Description
A 49-year-old man was referred to our hospital for atypical chest pain, without severe abdominal or back pain. He had a history of smoking and dyslipidaemia. His ECG showed no ST-T elevation. Coronary CT angiography (CTA) suggested moderate left anterior descending artery stenosis. CTA screening for aortic atherosclerosis showed significant calcification (figure 1A) and a crescent-shaped, mural low-density area in the infrarenal abdominal aorta (figure 1B,C). This was thought to be an intramural haematoma or a thrombosed false lumen. Calcified spots were deposited at the boundaries between the lumen and the low-density area (figure 1B,C). An intramural haematoma or a thrombosed type B dissection can be asymptomatic. Invasive coronary angiography showed no significant stenosis.
Figure 1
CT angiography images of the aorta. (A) Maximum intensity projection. Calcification deposited in the infrarenal abdominal aorta; however, a few calcifications were found in other sections....
https://ift.tt/2vIGb9C
Unusual congenital coronary artery anomaly in a young adult presenting as sudden cardiac arrest
A previously asymptomatic young female with no previous medical or cardiac history collapsed during indoor exercise. A portable automatic external defibrillator showed a shockable rhythm. She received multiple electrical shocks with return to normal sinus rhythm without ischaemic ECG changes. Her troponin level was mildly elevated. A transthoracic echocardiogram revealed moderately reduced left ventricular ejection fraction with global hypokinesis. During emergent coronary angiography, the left main coronary artery could not be found. The right coronary artery was normal with robust collaterals to the entire left coronary circulation extending to the left main coronary artery, but did not fill the ostium. Coronary CT angiogram confirmed nearly complete absence of the left main coronary artery ostium. A diagnosis of left main coronary artery atresia was made. Patient underwent successful two vessel coronary artery bypass grafting. She continues to do well 1 year postoperatively.
https://ift.tt/2HOiUIl
Corneal Epithelial Hyperplasia after 5-Fluorouracil Injection
Case Rep Ophthalmol 2018;9:254–256
https://ift.tt/2HqEaQM
The transformative power of research evaluation: effects on University governance and practices
Reale, E; Marini, G; (2014) The transformative power of research evaluation: effects on University governance and practices. In: (Proceedings) 8th ECPR General Conference, 3-6 September 2014, Glasgow, UK. European Consortium for Political Research (ECPR)
https://ift.tt/2HIm1Br
New Career Ladder patterns in Italian universities: habilitation through indicators of performance, age and ranks of positions
Marini, G; (2014) New Career Ladder patterns in Italian universities: habilitation through indicators of performance, age and ranks of positions. In: Heugens, P and Reus, T and Jansen, J, (eds.) (Proceedings) 30th EGOS Colloquium, 3-5 July 2014, Rotterdam, Netherlands. European Group for Organizational Studies (EGOS)
https://ift.tt/2vGcc1R
Recessive Ataxia Diagnosis Algorithm for the Next Generation Sequencing Era
Renaud, M; Tranchant, C; Torres Martin, JV; Mochel, F; Synofzik, M; van de Warrenburg, B; Pandolfo, M; ... the Working Group, RADIAL; + view all Renaud, M; Tranchant, C; Torres Martin, JV; Mochel, F; Synofzik, M; van de Warrenburg, B; Pandolfo, M; Koenig, M; Kolb, SA; Anheim, M; the Working Group, RADIAL; - view fewer (2017) Recessive Ataxia Diagnosis Algorithm for the Next Generation Sequencing Era. Annals of Neurology , 82 (6) pp. 892-899. 10.1002/ana.25084 .
https://ift.tt/2qTONp6
Revisiting the Popular Arts: Media Education, Cultural Values and Cultural Production
Burn, AN; (2017) Revisiting the Popular Arts: Media Education, Cultural Values and Cultural Production. In: de Abreu, B and Mihailidis, P and Lee, A and Melki, J and McDougall, J, (eds.) The Routledge international handbook of media literacy education. Routledge
https://ift.tt/2vEStQh
Rio de Janeiro 2016
Silvestre, G; (2016) Rio de Janeiro 2016. In: Gold, JR and Gold, MM, (eds.) Olympic Cities: City Agendas, Planning, and the World's Games, 1896 – 2020. Routledge: London, United Kindom. Green open access
https://ift.tt/2HGvb1c
Brazil, The Olympics and the FIFA World Cup
Silvestre, G; Horne, J; (2016) Brazil, The Olympics and the FIFA World Cup. In: Bairner, A and Kelly, J and Lee, JW, (eds.) Routledge Handbook of Sport and Politics. Routledge: London, United Kindom. Green open access
https://ift.tt/2vFVBeB
Im/material objects: Relics, gestured signs and the substance of the immaterial
Carroll, TA; (2016) Im/material objects: Relics, gestured signs and the substance of the immaterial. In: Materiality and the Study of Religion The Stuff of the Sacred. Routledge
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Crossed Colonization. Housing Development in Urban Peripheries. The Hispanic-African Colonial Territories, 1912 – 1976 – 2013
Sendra Fernandez, P; González Martínez, P; Carrascal Pérez, M; Memba Ikuga, L; Rabasco Pozuelo, P; Muchada Suárez, A; (2015) Crossed Colonization. Housing Development in Urban Peripheries. The Hispanic-African Colonial Territories, 1912 – 1976 – 2013. In: Nunes da Silva, C, (ed.) Urban Planning in Sub-Saharan Africa: colonial and postcolonial planning cultures. (pp. 180-200). Routledge: New York, New York. Green open access
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Digital and New Technologies: Research Tools and Questions
Kucirkova, N; Messer, D; (2016) Digital and New Technologies: Research Tools and Questions. In: Practical Research with Children. Routledge Green open access
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