Clinical Thyroidology for the Public – Highlighted Article

From Clinical Thyroidology for the Public: There has been a steady rise of thyroid cancers over the past several decades. Some of this is likely due to the increased use of imaging such as CT scans. However, it is likely that other factors play a role as well, including chemicals in our environment. Read More….

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Hipoacusia: Un nuevo factor de riesgo para demencia

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Quistes de cuerda vocal: Experiencia en 44 pacientes del Centro de Voz del Departamento de Otorrinolaringología de la Pontificia Universidad Católica de Chile

RESUMEN Introducción: Los quistes de cuerda vocal son una causa relativamente frecuente de disfonía. Su origen es aún controversial, y su diagnóstico y manejo continúan siendo un desafío clínico. Objetivo: Exponer y analizar las características clínicas de los quistes de cuerda vocal en nuestra serie de pacientes. Material y método: Estudio retrospectivo descriptivo de los pacientes con diagnóstico de quiste de cuerda vocal atendidos en nuestro centro entre junio de 2012 y diciembre de 2015. Resultados: Se atendieron 44 pacientes con diagnóstico de quiste de cuerda vocal, lo que representa el 4,32% de las consultas en nuestro Centro de Voz. La mayoría de los pacientes fueron adultos, y de ellos el 68,29% correspondió a mujeres. El 34,1% de los pacientes fueron sometidos a tratamíento quirúrgico con técnica de microfonocirugía. El 75% de los pacientes operados presentó mejoría en patrón de onda mucosa videolaringoestroboscópica. Todos los pacientes en los que se disponía de encuestas de valoración subjetiva de la voz pre y posoperatorias demostraron mejoría vocal significativa. Conclusión: Los quistes de cuerda vocal son lesiones que afectan a niños y adultos. La videolaringoestroboscopía es clave en el diagnóstico de estas lesiones, y el tratamiento quirúrgico con microfonocirugía es efectiva en cuanto a resultados vocales desde el punto de vista anatómico y funcional.

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ABSTRACT Introduction: Vocal cord cysts are a relatively frequent cause of dysphonia. Their origin is still controversial, and their diagnosis and management continue to be a clinical challenge. Aim: To describe and analyze the clinical characteristics of vocal cord cysts in our series of patients. Material and method: Descriptive retrospective study of patients with diagnosis of vocal cord cyst attended in our center between June 2012 and December 2015. Results: 44 patients had the diagnosis of vocal cord cyst, which represents 4.32% of the patients that attended our Voice Center during that period. Most of the patients were adults, and among them 68.29% corresponded to women. 34.1% of the patients were submitted to surgical treatment with microphonosurgery technique. 75% of the surgical patients presented an improvement in the pattern of the videolaryngostroboscopic mucosal wave. All the patients in which pre and postsurgical subjective voice assessment polls were available, showed a significant voice improvement. Conclusion: Vocal cord cysts are lesions that affect both children and adults. The videolaryngostroboscopy evaluation is key in the diagnosis of these lesions, and the surgical treatment with microphonosurgery is effective in terms of anatomical and functional vocal results.

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Sinus Tympani y recidiva en cirugía de colesteatoma

RESUMEN Introducción: El sinus tympani (ST) es una de las áreas que más presenta colesteatoma residual. Recientemente se ha clasificado en 3 tipos de acuerdo a su morfología. Objetivos: Determinar el tipo de ST en los pacientes sometidos a cirugía de colesteatoma y analizar su impacto como factor de recidiva. Material y método: Revisión de fichas clínicas de pacientes sometidos a cirugía de colesteatoma entre los años 2004 y 2015 en el Hospital Regional de Concepción. Análisis de la tomografía axial computarizada (TAC) preoperatoria y posterior evaluación clínica de los pacientes operados mediante mastoidectomía canal wall down (CWD). Resultados: En el periodo descrito se operaron 271 oídos. El 60% de los casos analizados presentó ST tipo A y 40% ST tipo B. Se identificaron 12 casos de recidiva, 3 ST tipo B y 9 ST tipo A, sin diferencia estadísticamente significativa entre ambos. Discusión: Distinto a lo reportado en la literatura el tipo de ST más frecuente en nuestro estudio fue el tipo A, lo que podría corresponder a una variable étnica. Conclusión: El estudio preoperatorio con TAC es una herramienta útil para evaluar el tipo y compromiso del ST. Las diferencias anatómicas entre ST tipo A y B parece no ser un factor determinante de recidiva en mastoidectomías CWD.

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ABSTRACT Introduction: Sinus tympani (ST) is one of the areas with the most residual cholesteatoma. Recently it has been classified in 3 types according to its morphology. Aim: To determine the type of ST in patients undergoing cholesteatoma surgery and to analyze its impact as a relapse factor. Material and method: Review of clinical files of patients submitted to cholesteatoma surgery between 2004 and 2015 at the Regional Hospital of Concepción. Preoperative computed axial tomography (CT) analysis and subsequent clinical evaluation of patients operated by canal wall down mastoidectomy (CWD). Results: In the described period 271 ears were operated. 60% of the cases analyzed had ST type A and 40% ST type B. Twelve cases of relapse were identified, 3 ST type B and 9 ST type A, with no statistically significant difference between the two. Discussion: Unlike to what is reported in the literature, the most common ST type in our study was type A, which could correspond to an ethnic variable. Conclusion: The preoperative study with CT is a useful tool to evaluate the type and commitment of ST. The anatomical differences between ST type A and B seems not to be a determinant factor of relapse in CWD mastoidectomies.

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Fibroangioma nasofaríngeo juvenil. Experiencia de 15 años en el Hospital Barros Luco Trudeau

RESUMEN Introducción: El fibroangioma nasofaríngeo juvenil es un tumor vascular benigno localmente agresivo, que afecta casi exclusivamente la nasofaringe de adolescentes de sexo masculino. Su manejo es complejo dada su extensión, naturaleza vascular y sus frecuentes recurrencias. Objetivo: Mostrar la experiencia de 15 años en fibroangioma juvenil en nuestro centro. Material y método: Estudio descriptivo retrospectivo de los pacientes con diagnóstico de ingreso de fibroangioma nasofaríngeo juvenil al Servicio de Otorrinolaringología del Hospital Barros Luco Trudeau entre los años 1997 y 2011, caracterizando al grupo de estudio en cuanto a características clínico-demográficas, vasos aferentes, relación entre etapa tumoral y vascularización, manejo terapéutico, complicaciones y recurrencias. Resultados: Se obtuvo un total de 20 pacientes, todos de sexo masculino, con un promedio de edad de 13,9 años. El síntoma de presentación más frecuente fue la epistaxis a repetición y obstrucción nasal presente en el 90% y 80%, respectivamente. Todos los pacientes se estudiaron con tomografia computarizada y recibieron embolización arterial preoperatoria. La mayoría de los tumores fueron de tipo II (65%) y III (20%), según clasificación de Radkowski. La técnica quirúrgica más empleada fue abierta (57,8%). Radioterapia en un caso. El vaso aferente principal fue la maxilar interno ipsilateral en el 100%. Todos los fibroangiomas etapa III eran además irrigados por la arteria carótida interna. Se encontró 20% de persistencia y 15% de recidiva. Conclusión: Nuestros resultados concuerdan con la gran mayoría de las series publicadas en la literatura. Epistaxis recurrente, obstrucción nasal y tumor nasal unilateral deben hacernos sospechar de esta patología en un adolescente masculino. El tratamiento de elección es la cirugía con embolización preoperatoria. La vía de abordaje endoscópica presenta menor morbilidad posoperatoria en pacientes con estadios I y II de Radkowski. Todos los fibroangiomas con compromiso intracraneano, presentan irrigación también del sistema carotideo interno.

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ABSTRACT Introduction: Nasopharyngeal Fibroangioma is a locally aggressive benign vascular tumor. Its management is complex given its size, vascular nature and its frequent recurrences. Aim: To show the experience of 15 years in Juvenile Fibroangioma in our center. Material and method: Retrospective descriptive study of patients admitted with a diagnosis of Juvenile Fibroangioma Nasopharyngeal in the Department of Otolaryngology Hospital Barros Luco Trudeau between 1997 and 2011. Results: A total of 20 patients was obtained. The most common presenting symptom was recurrent epistaxis and nasal obstruction present in 90% and 80% respectively. The most common surgical technique was open (57.8%). Radiotherapy in one case. The main afferent vessel was the ipsilateral internal maxillary in 100%. All Fibroangioma stage III were also supplied by the internal carotid artery. 20% of persistence and 15% of recurrence was found. Conclusion: Recurrent epistaxis, nasal obstruction and unilateral nasal tumor should raise the suspicion of this disease in a male teenager. The treatment of choice is surgery with preoperative embolization. The route of endoscopic approach has less postoperative morbidity in patients with stage I and II of Radkowski. All Fibroangioma with intracranial commitment, have also the internal carotid irrigation system.

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Causas de rinoplastía secundaria: Análisis de 277 casos

RESUMEN Introducción: La rinoplastía secundaria cada día es más frecuente debido a la creciente popularidad de la cirugía estética y también por las mayores expectativas del paciente y del cirujano. La rinoplastía secundaria ha llegado a ser un campo en evolución con desafíos únicos. Para enfrentarlo adecuadamente el cirujano debe analizar y comprender las necesidades específicas del paciente y las causas anatómicas que generaron el problema y cómo corregirlo. Objetivo: Identificar los problemas anatómicos más frecuentemente encontrados en 277 rinoplastías secundarias y sistematizarlos para una mejor evaluación preoperatoria y planificación quirúrgica. Material y método: Análisis retrospectivo de 1.160 rinoplastías operadas por el otorrinolaringólogo Dr. Luis Villarroel entre el 1 de enero de 2006 y el 31 de marzo de 2015, de las cuales 277 son rinoplastías secundarias (24%). En ellas se encontraron 1.197 problemas o deformidades (4,3 promedio), que se dividieron en tercio superior, medio, inferior y endonasales, con una subdivisión de deformidades individuales dentro de cada grupo. También se comparan los resultados encontrados según si la cirugía primaria fue de otro cirujano (rinoplastías secundarias) o del mismo autor (rinoplastías de revisión). Resultados: El 85% de los pacientes presentó problemas en el tercio inferior. Los problemas más frecuentes fueron desviación del tabique nasal (problema endonasal) (56%), punta hiporotada (47%), desviación del dorso óseo (34%) y desviación del dorso cartilaginoso (30%). Las rinoplastías de revisión, comparadas con las secundarias, presentan un porcentaje mayor de problemas de insuficiente resección del dorso óseo y menos dorsos cartilaginosos estrechos. Conclusión: Existen diferentes razones por las que un paciente busca una rinoplastía secundaria. Es importante conocer las causas más frecuentes con el fin de identificar los errores cometidos en el primer caso y evitar dichas prácticas. Es preferible una cirugía primaria conservadora porque evita problemas difíciles de resolver. Esta clasificación nos ayuda a sistematizar el análisis preoperatorio, a saber, dónde estamos teniendo problemas y así corregirlos y obtener mejores resultados quirúrgicos.

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ABSTRACT Introduction: Secondary rhinoplasty is becoming increasingly common due to the growing popularity of cosmetic surgery and also by higher expectations of the patient and the surgeon. Secondary rhinoplasty has become an evolving field with unique challenges. To repair the surgeon must properly analyze and understand the specific concerns of the patient and the anatomical causes of why you need a new operation. Aim: To identify anatomical problems most frequently found in 277 secondary and systematize rhinoplasty for better preoperative evaluation and surgical planning. Material and method: Retrospective analysis of 1160 rhinoplasty operated by otolaryngologist Dr. Luis Villarroel between January 1006 and March 31, 2015, of which 277 are secondary rhinoplasty (24%). In this study we found 1197 problems or deformities (average 4.3), They were classified into upper, middle, bottom third ,and endonasal, with an individual deformities subdivision within each group. The results are compared if the primary surgery was another surgeon (secondary rhinoplasty of others) or by the same author (revision rhinoplasty). Results: 85% of patients had problems in the lower third. The most common individual problems identificated were deviated septum (56%), drop tip (47%), bone dorsum deviation (34%), and cartilaginous dorsum desviation (30%). The author presents a higher percentage of insufficient bone resection and less cartilaginous dorsum narrow. Conclusion: There are different reasons why a patient seeks a secondary rhinoplasty. It is important to know the most frequent causes in order to identify the mistakes made in the first instance and avoid them. It's preferable one conservative primary surgery because it avoids difficult problems. This classification helps us to systematize the preoperative analysis and better results.

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Revestimiento interno en reconstrucción nasal: Estudio anatómico cadavérico

RESUMEN Introducción: Ante la presencia de un defecto anatómico nasal, se hace necesario considerar alternativas para restituir una correcta función y estética nasal. La estructura osteocartilaginosa nasal debe contar con un soporte o revestimiento interno que aporte una vascularización necesaria. Existen diversas técnicas de colgajos intranasales para lograr reconstituir el revestimiento interno nasal. Objetivos: Describir la técnica quirúrgica de los principales colgajos de revestimiento interno en reconstrucción nasal y su aplicación en modelos ex vivo. Material y método: Se realizó la disección de 7 especímenes de donante cadáver. Se efectuó una resección amplia nasal simulando una pérdida de tejido de las 3 capas de la anatomía nasal para su posterior reconstrucción. Resultados: Se logró replicar las distintas alternativas de técnicas de colgajos intranasales descritas para reconstrucción nasal. Conclusión: El revestimiento interno es de suma importancia en la reconstrucción nasal. Esta es una primera fase en el desarrollo y aprendizaje de la reconstrucción nasal.

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ABSTRACT Introduction: In the presence of a nasal anatomical defect, it is necessary to consider alternatives to restore a correct function and esthetic nasal result. The nasal osteocartilaginous structure must have an internal support or lining that provides a necessary vascularization. There are various techniques of intranasal flaps to achieve reconstitution of the nasal internal lining. Aim: To describe the surgical technique of the main internal lining flaps in nasal reconstruction and its application in ex vivo models. Material and method: We dissected 7 cadaver donor specimens. A broad nasal resection was performed simulating a loss of tissue from the three layers of the nasal anatomy for subsequent reconstruction. Results: It was possible to replicate the different alternatives of intranasal flap techniques described for nasal reconstruction. Conclusion: The inner lining is of paramount importance in nasal reconstruction. This is a first phase in the development and learning of nasal reconstruction.

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Manejo endoscópico de anomalías del cuarto arco branquial: Reporte de tres casos

RESUMEN Las anomalías de cuarto arco branquial corresponden a una entidad patológica infrecuente. Para su manejo existen distintas alternativas terapéuticas siendo una de ellas la cauterización endoscópica. Reportamos 3 casos de senos de cuarto arco branquial tratados mediante cauterización endoscópica en el Hospital Regional de Concepción luego de una revisión de fichas clínicas de todos los pacientes con diagnóstico de anomalías de cuarto arco branquial. Se identificaron tres casos de senos de cuarto arco branquial. Todos corresponden a pacientes de sexo masculino que presentaron cuadro de absceso cervical, diagnosticándose 2 de ellos al presentar recurrencia. Todos fueron tratados mediante cauterización endoscópica de la apertura fistulosa en seno piriforme. Estas anomalías representan vestigios de un trayecto que se origina desde el vértice del seno piriforme. La cauterización endoscópica presenta una serie de ventajas con tasas de recurrencia similares a la cirugía abierta de cuello, menores tasas de complicaciones y costo económico. Las anomalias de cuarto arco branquial constituyen una patología infrecuente y el diagnóstico requiere alta sospecha clínica. El manejo endoscópico ha demostrado ser una alternativa segura y efectiva con menor tasa de complicaciones.

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ABSTRACT Anomalies of the fourth branchial arch correspond to an uncommon pathological entity. There are different therapeutic alternatives being one of them the endoscopic cauterization. We report 3 cases of fourth branchial arch anomalies treated by endoscopic cauterization in the Regional Hospital of Concepción. Review of clinical records of all patients with diagnosis of fourth branchial anomalies operated by endoscopic cauterization at the Regional Hospital of Concepción. Cases: Three cases of fourth branchial arch sinus were identified. All of them were male patients who presented with a cervical abscess, diagnosing 2 of them when they recurred. All 3 cases were treated by endoscopic cauterization of the fistulous opening in the piriform sinus. These anomalies represent vestiges of a path that originates from the apex of the piriform sinus. Endoscopic cauterization presents a number of advantages with recurrence rates similar to open neck surgery, with lower complication rates and economic cost. Fourth branchial anomalies constitute an uncommon pathology and the diagnosis requires high clinical suspicion. Endoscopic management has proven to be a safe and effective alternative with a lower rate of complications.

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Manejo endoscópico de osteoma etmoidal con extensión orbitaria: A propósito de un caso

RESUMEN El osteoma es el tumor más frecuente de los senos paranasales, habitualmente asintomático debido a su lento crecimiento, sin embargo, pueden desarrollarse síntomas dependiendo del tamaño, localización y extensión, con potencial compromiso de órbita y cerebro. La cirugía está indicada en casos sintomáticos pudiendo realizarse abordaje externo, endoscópico o combinado. Presentamos un caso de osteoma etmoidal con compromiso orbitario resuelto, manejado por medio de la cirugía endoscópica nasal, con apoyo de navegación.

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ABSTRACT The osteoma is the most common tumor of the paranasal sinuses, is usually asymptomatic because of their slow growth, however, may develop symptoms depending on the size, location and extent, with potential compromise of orbit and brain. Surgery is indicated in symptomatic cases, with external, endoscopic or combined approach. We present a case of ethmoidal osteoma with orbital involvement managed by endoscopic image guided surgery.

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Paroxismia vestibular: Reporte de un caso

RESUMEN Presentamos el caso de un paciente joven quien presenta 4 a 5 crisis diarias de vértigo espontáneo de segundos de duración, todos o casi todos los días desde hace 9 meses. Estas crisis no tienen gatillo posicional, y hay completa ausencia de sintomatologia entre crisis. Como discutimos en el artículo, este cuadro coíncide con los recientemente publicados criterios para una paroxismia vestibular, entidad supuestamente secundaria a la compresión neurovascular del nervio vestibular. El paciente respondió de forma inmediata y completa a carbamazepina a dosis bajas, el tratamiento de elección en la paroxismia vestibular.

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ABSTRACT We present the case of a young patient, with a 9-month long history of 4 to 5 daily spells of spontaneous vertigo, each lasting only seconds. There is no positional trigger, and there is a complete lack of symptoms between attacks. As is discussed in the article, this matches the recently published criteria for Vestibular Paroxysmia, an entity allegedly secondary to neurovascular compression of the vestibular nerve. The patient responded immediately and completely to carbamazepine at low dosage, the preferred treatment for vestibular paroxysmia.

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Carcinoma parotídeo epitelial-mioepitelial: Presentación de un caso y revisión de la literatura

RESUMEN Se presenta caso de paciente de sexo femenino de 53 años de edad con tumor parotídeo izquierdo de larvada evolución, con crecimiento progresivo y otalgia ipsilateral en los últimos meses, estudiado previamente con tomografía de cuello con contraste y resonancia magnética que destacan masa del lóbulo profundo de la parótida de características imagenológicas benignas. Se realizó parotidectomía del lóbulo profundo con resección tumoral preservando el nervio facial casi en su totalidad con excepción de rama marginal, la biopsia de la pieza quirúrgica fue informada como carcinoma epitelialmioepitelial de bajo grado, un tumor infrecuente de las glándulas salivales. Se decidió completar la parotidectomía superficial y realizar vaciamiento ganglionar selectivo lateral ipsilateral, complementando el tratamiento con radioterapia. Además se presenta una revisión de la literatura correspondiente.

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ABSTRACT We present a case of a 53 years old female patient with a left parotid tumor, with slow evolution, progressive growth and ipsilateral otalgia during later months. She was previously studied by tomography of the neck with contrast and magnetic resonance, which showed the mass of the deep lobe to have benign imaging characteristics. A parotidectomy of deep lobe was performed, with tumoral resection, preserving the facial nerve with the exception of the marginal branch. The biopsy was informed as epithelial-myoephitelial carcinoma, a rare salivary gland tumor. We completed the parotidectomy with neck dissection and Radiotherapy complementary was made. Besides we presented a literature review.

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Carcinosarcoma de laringe: Reporte de dos casos

RESUMEN El carcinosarcoma de laringe es un tumor bifásico raro que representa menos del 1% de todos los tumores malignos de laringe. Debido a su doble naturaleza epitelial y mesenquimal esta neoplasia ha sido denominada de distintas maneras en la literatura, siendo indispensable el estudio mediante inmunohistoquímica para establecer un diagnóstico correcto. Se presentan 2 casos de carcinosarcoma de laringe, confirmados mediante estudio con inmunohistoquímica, ambos tratados mediante laringectomía total. Se elabora una discusión de los principales aspectos clínicos, histopatológicos y terapéuticos de esta infrecuente neoplasia.

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ABSTRACT The larynx carcinosarcoma is a rare biphasic tumor that represents less than 1% of all malignant tumors of the larynx. Because of its biphasic epithelial and mesenchymal nature this neoplasm has been called in different ways in the literature being indispensable the study by immunohistochemistry to establish a proper diagnosis. We present 2 cases of larynx carcinosarcoma confirmed by immunohistochemical study, both treated with total laryngectomy. A discussion of the main clinical, histopathological and therapeutic aspects of this rare neoplasm is made.

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Enfisema subcutáneo masivo, nemotórax a tensión y neumomediastino tras traqueotomía percutánea

RESUMEN Mujer de 68 años que ingresa en la Unidad de Cuidados Intensivos por shock séptico. En el posoperatorio la paciente se mantiene inestable y se decide realizar traqueotomía percutánea (TP) por intubación prolongada. Al inicio la paciente presenta un enfisema subcutáneo que progresa hasta convertirse en masivo. Se realiza TC torácico donde se observa pérdida de la morfología habitual de la pared posterior traqueal con solución de continuidad. Tras revisión mediante traqueobroncoscopía se decide colocar cánula de traqueotomía larga para dejar la lesión proximal al neumotaponamiento y así evitar la fuga de aire. Desde la colocación de la nueva cánula, la paciente presenta una disminución progresiva del enfisema hasta su total resolución. La TP es un procedimiento seguro que se realiza con mucha frecuencia en los servicios de medicina intensiva, sin embargo, no está exenta de complicaciones. En la revisión de Powell y cols describen las complicaciones de la TP destacando la inserción peritraqueal, la hemorragia, las infecciones de la herida, el neumotórax y la muerte. El rango de complicaciones en la literatura oscila entre 3% y 18%. Además, no se encuentran diferencias significativas respecto a las complicaciones entre la TP y la técnica abierta.

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ABSTRACT A 68-year-old woman who enter in intensive care unit due to septic shock. In the postoperative period, the patient remained unstable and decided to perform a percutaneous tracheotomy (PT) because prolonged intubation. In the first, the patient presents subcutaneous emphysema that progresses until becoming massive. Thoracic CT is performed where loss of the usual morphology of the posterior tracheal wall with continuity solution is observed. After revision by means of tracheobroncoscopia, it is decided to place a long tracheotomy cannula to leave the lesion proximal to pneumotaponamiento and thus avoid air leakage. From the placement of the new cannula, the patient presents a progressive decrease of the emphysema until its total resolution. PD is a safe procedure that is performed very frequently in the Intensive Care Services3, however, it is not without its complications. The review of Powell et al4 describes the complications of PT emphasizing peritracheal insertion, hemorrhage, wound infections, pneumothorax, and death. The range of complications in the literature ranges from 3 to 18% 5. In addition, no significant differences were found regarding the complications between the TP and the open technique.

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Tuberculosis como causa de adenopatías cervicales

RESUMEN La tuberculosis (TBC) es una enfermedad infecto-contagiosa de distribución mundial causada por Mycobacterium tuberculosis, y otras micobacterias atípicas. La afectación ganglionar es tardía y sus manifestaciones clínicas asociadas suelen ser inespecíficas, por eso, el diagnóstico de tuberculosis ganglionar a menudo se retrasa y es un hallazgo inesperado en numerosas ocasiones. Este artículo pretende realizar una revisión bibliográfica sobre la tuberculosis ganglionar y hacer hincapié en que la TBC ha de ser tenida en cuenta como diagnóstico diferencial en las masas cervicales, que muchas veces se presentan con escasa sintomatología acompañante. En este artículo presentamos dos casos de TBC ganglionar diagnosticados en nuestro servicio en los últimos meses, ambos casos se manifestaron exclusivamente como masa cervical de crecimiento lento, sin síntomas pulmonares acompañante y fueron diagnosticados de TBC tras el estudio anatomopatológico resultante de la exéresis quirúrgica de la lesión.

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ABSTRACT The tuberculosis (TB) is an infect-contagious worldwide distribution disease caused by Mycobacterium Tuberculosis and other atypical Mycobacteria. Lymph node involvement is late, and its associated clinical manifestations are usually unspecifics, therefore the diagnosis of tuberculosis lymph node is often delayed and is an unexpected finding in numerous occasions. This article aims to carry out a literature review of lymph node tuberculosis and to emphasize that TB must be taken into account as differential diagnosis in cervical masses, which often occur with few associated symptoms. In this article we present two cases of lymph node TB diagnosed in our department in last months, both cases presented exclusively as cervical mass of slow growth, without any accompanying pulmonary symptoms and were diagnosed as TB after the surgical removal of the lesion and its histopathological study.

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Revisión sobre los conocimientos actuales de dehiscencia del canal semicircular posterior

RESUMEN La dehiscencia del canal semicircular posterior es una patología rara y con baja incidencia, por ello hemos realizado una revisión de los conocimientos actuales de esta entidad. Se ha realizado una búsqueda bibliográfica desde 1998 hasta diciembre de 2016 de toda la literatura publicada sobre la misma en las bases de datos Allied and Complementary Medicine Database and the Embase, Health Management Information Consortium, Scopus, Consortium, Medline, PsycINFO y Scielo. Se han encontrado y revisado 53 trabajos relacionados con el tema. La dehiscencia del canal semicircular posterior presenta una prevalencia variable; 0,3%-4,5% en adultos y 1,2%-20% en niños. Su localización puede ser hacia el golfo de la yugular o fosa cerebral posterior. Los pacientes pueden ser asintomáticos o presentar clínica auditiva y/o vestibular. La tomografía computarizada y la prueba de potenciales vestibulares miogénicos evocados permiten establecer el diagnóstico de certeza. En el tratamiento quirúrgico la vía de abordaje de elección es la transmastoidea y las técnicas del cierre del canal son el "plugging" y el "resurfacing".

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ABSTRACT The posterior semicircular canal dehiscence is a rare pathology and it has a low incidence. We have realized a review about the current knowledge of this entity. We have performed a bibliographic research from 1998 to 2016 December about the literature published in this subject, in the data basis Allied and Complementary Medicine Database and the Embase, Health Management Information Consortium, Scopus, Consortium, Medline, PsycINFO y Scielo. I thas been found and reviewed 53 papers about the topic. The posterior semicircular canal dehiscence has a variable prevalence: 0,3%-4-5% in adults and 1,2%-20% in children. The location can be in the jugular bulb or in the posterior brain fossa. Some patients can be asymptomatic, whereas others can have auditory and/or vestibular signs and symptoms. Computed tomography and test of vestibular evoked myogenic potentials allow the diagnosis of certainty. In the surgical treatment the approach of choice is transmastoid and techniques to close the canal are plugging and resurfacing.

http://ift.tt/2h9G0KS

Hipertrofia de amígdala lingual y apnea obstructiva del sueño en población pediátrica: Una asociación a considerar

RESUMEN Las amígdalas linguales (AL) forman parte del Anillo de Waldeyer (AW). La hipertrofia de amígdala lingual (HAL) se debe habitualmente a hiperplasia, generalmente asintomática. Su etiología no está precisada, pero se reconoce como causa de Apnea Obstructiva del Sueño (AOS) residual, posterior a adenoamigdalectomía (AA). Su identificación en el examen físico es dificultosa, por lo que resulta relevante la sospecha, junto con una nasofibroscopía. Según condiciones y sintomatología del paciente se puede complementar el estudio con otras técnicas diagnósticas, como polisomnograma (PSG) y resonancia magnética (RM). La cirugía es exitosa para el tratamiento de estos casos. Dentro de las complicaciones descritas para este procedimiento destacan: hemorragia, obstrucción de la vía área, dificultad en la intubación orotraqueal y dolor en el posoperatorio. Actualmente no existe una técnica quirúrgica de elección. Debido a la morbilidad asociada a AOS resulta fundamental el diagnóstico de esta patología, ya que es susceptible de tratamiento.

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ABSTRACT Lingual tonsils are part of Waldeyer`s Ring. The hypertrophy of the lingual tonsils is generally due to hiperplasia, without symptoms. The etiology is not clear, but it is a known cause of residual Obstructive Sleep Apnea (OSA), after adenotonsilectomy. Their identification during the physical exam results dificult, so the suspicious and the nasofibroscopy are relevant. Acording to the particular patient it is posible realize additional exams, like polisomnography and magnetic nuclear resonance. Surgery is succesful for this cases. The complications include: bleeding, airway obstruction, anestesia dificulties and pain. Currently there is not a particular techniqe of choice. OSA is associated to morbidity, therefore it is fundamental to diagnose this pathology, because it is posible to treat it through surgery.

http://ift.tt/2zDILeh

Crisis otolítica de Tumarkin. Revisión de la literatura

RESUMEN Las crisis de Tumarkin consisten en caídas bruscas al suelo sin pródromos previos ni pérdida de conciencia y de segundos de duración que pueden ocurrir con frecuencia relativa en pacientes con enfermedad de Ménière. Si bien pueden presentarse de manera aislada durante la evolución de la enfermedad, existen casos con crisis recurrentes que comprometen significativamente la calidad de vida de los pacientes. Se postula que las crisis se producen por una alteración de la función del órgano otolítico, específicamente del sáculo. El tratamiento puede ser desde el manejo expectante hasta el uso de laberintectomía química o quirúrgica.

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ABSTRACT Tumarkin´s otolithic crisis is a sudden fall that comes with no loss of consciousness, and without warning or prodrome. It has a short duration and can occur with relative frequency in patients with Meniere disease. When it is present, it significantly compromises life quality of patients. There is no certainty about its mechanism, but it is assumed that the crises are caused by an otolithic organ disfunction, specifically a collapse of the saccule. Treatment can range from observation to chemical or surgical labyrinthectomy.

http://ift.tt/2zGj3pc

Prueba de patrones de frecuencia y patrones de duración: Evaluación del ordenamiento auditivo temporal

RESUMEN Los aspectos temporales de la audición se consideran unos de los mecanismos claves del procesamiento auditivo, ya que resultarían críticos para el adecuado funcionamiento del resto de los procesos auditivos centrales. El ordenamiento auditivo temporal es una de las cuatro habilidades de los aspectos temporales de la audición y se refiere al procesamiento de dos o más estímulos auditivos según su orden de aparición u ocurrencia en el dominio temporal. Ha sido uno de los procesos más ampliamente estudiados debido a sus implicancias en el resto de las habilidades auditivas, así como también en numerosas actividades de la vida diaria, incluyendo la percepción y la discriminación de los sonidos del habla. Históricamente se han utilizado dos pruebas para evaluarlo: la prueba de patrones de frecuencia y la prueba de patrones de duración. Ambas pruebas cuentan con buena sensibilidad y especificidad para detectar lesiones del sistema nervioso auditivo central, incluyendo el hemisferio derecho, izquierdo y cuerpo calloso. En la actualidad, ambas pruebas son utilizadas con frecuencia debido a su eficiencia, su facilidad para ser administrada y la disponibilidad de valores normativos para un amplio rango de población. Se recomienda ampliamente su utilización en la práctica clínica considerando la obtención de valores normativos locales.

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ABSTRACT The temporal aspects of audition are considered one of the key mechanisms of auditory processing, as they would be critical for the proper functioning of the rest of the central auditory processes. The auditory temporal ordering is referred to one of the four skills of the temporal aspects of audition and refers to the processing of two or more auditory stimuli in their order of appearance or occurrence in the time domain. It has been one of the most widely studied processes due to its implications for the rest of listening skills, as well as in numerous activities of daily life, including perception and discrimination of speech sounds. Historically, two test has been used to evaluate: the frequency pattern and duration pattern tests. Both tests have good sensitivity and specificity to detect lesions at the central auditory nervous system, such as right and left hemisphere and corpus callosum dysfunctions. Currently, both tests are commonly used clinically due to its efficiency, ease of administration and the availability of normative data in wide range of population. Their use is strongly recommended in clinical practice considering obtaining local normative values.

http://ift.tt/2h9FOeC

Diagnóstico en la patología del olfato: Revisión de la literatura

RESUMEN La patología del olfato es una afección común en la población, principalmente en adultos mayores, que puede alterar de manera significativa la calidad de vida del paciente, pudiendo ser la manifestación inicial de enfermedades neurológicas como la enfermedad de Parkinson. A pesar de su relevancia, el sentido del olfato continúa siendo poco estudiado en clínica, no obstante la existencia de métodos simples validados para su evaluación. En este articulo realizamos una revisión y análisis de la literatura actual sobre el estudio clínico del olfato, con el objetivo de establecer las herramientas diagnósticas disponibles en la práctica clínica para su estudio.

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ABSTRACT Olfactory diseases are common to find in the population, mainly in older people, and it can affect significantly life quality. It can also be the first manifestation of neurological diseases, such as Parkinson disease. Despite its relevance, the sense of smell is still not studied although there are simple and validated methods available in the clinical practice. In this article, we make a review and analysis of the actual literature related to smell studies, so that we can establish available diagnosis tools in the clinical practice.

http://ift.tt/2zFmAEp

T cell-mediated immune response to pneumococcal conjugate vaccine (PCV-13) and tetanus toxoid vaccine in patients with moderate to severe psoriasis during tofacitinib treatment

Psoriasis is often treated with immunomodulatory therapies that may affect immune response to common antigens. Tofacitinib is an oral Janus kinase inhibitor.

http://ift.tt/2yNYrwj

Preventing new sensitization and asthma onset by allergen immunotherapy: the current evidence

Purpose of review: Specific allergen immunotherapy is considered a key candidate for a successful preventive intervention in atopic diseases. The strong association of atopic manifestations such as rhinitis and asthma with atopic sensitizations (specific serum IgE) provide a rationale for early intervention in childhood and adolescence. Recent findings: Currently, the documentation of the disease-modifying intervention effects is limited to the secondary prevention of asthma symptoms in children with allergic rhinoconjunctivitis. These effects appear to be rather allergen specific than nonspecific. Summary: Documentation on disease modification including a reduction of asthma symptoms in children, particularly with grass pollen tablets has become quite robust. It is not clear up to now, if the new onset of allergic sensitizations can be modified. So far data on primary prevention are not conclusive.

http://ift.tt/2iy0AYH

An update on gain-of-function mutations in primary immunodeficiency diseases

Purpose of review: Most primary immunodeficiencies described since 1952 were associated with loss-of-function defects. With the advent and popularization of unbiased next-generation sequencing diagnostic approaches followed by functional validation techniques, many gain-of-function mutations leading to immunodeficiency have also been identified. This review highlights the updates on pathophysiology mechanisms and new therapeutic approaches involving primary immunodeficiencies because of gain-of-function mutations. Recent findings: The more recent developments related to gain-of-function primary immunodeficiencies mostly involving increased infection susceptibility but also immune dysregulation and autoimmunity, were reviewed. Updates regarding pathophysiology mechanisms, different mutation types, clinical features, laboratory markers, current and potential new treatments on patients with caspase recruitment domain family member 11, signal transducer and activator of transcription 1, signal transducer and activator of transcription 3, phosphatidylinositol-4,5-biphosphate 3-kinase catalytic 110, phosphatidylinositol-4,5-biphosphate 3-kinase regulatory subunit 1, chemokine C-X-C motif receptor 4, sterile α motif domain containing 9-like, and nuclear factor κ-B subunit 2 gain-of-function mutations are reviewed for each disease. Summary: With the identification of gain-of-function mutations as a cause of immunodeficiency, new genetic pathophysiology mechanisms unveiled and new-targeted therapeutic approaches can be explored as potential rescue treatments for these diseases.

http://ift.tt/2iBsy5L

Editorial introductions

No abstract available

http://ift.tt/2izXzHq

NLRC4 inflammasomopathies

Purpose of review: The purpose of the review is to highlight developments in autoinflammatory diseases associated with gain-of-function mutations in the gene encoding NLR-family CARD-containing protein 4 (NLRC4), the NLRC4-inflammasomopathies. Recent findings: Three years since the identification of the first autoinflammation with infantile enterocolitis (AIFEC) patients, there is an improved understanding of how the NLRC4 inflammasome and interleukin 18 (IL-18) contribute to gut inflammation in myeloid and also intestinal epithelial cells. This information has opened new therapeutic avenues to treat AIFEC patients with targeted agents like recombinant IL-18 binding protein and antiinterferon-γ antibodies. Additional phenotypes traditionally associated with NLRP3 mutations like familial cold autoinflammatory syndrome and neonatal onset multisystem inflammatory disease (NOMID), have now also been associated with gain-of-function NLRC4 mutations. Finally, NLRC4 somatic mosaicism has now been identified in a NOMID and an AIFEC patient, a finding emphasizing nontraditional modes of inheritance in autoinflammatory diseases. Summary: The NLRC4 inflammasomopathies constitute a growing autoinflammatory disease category that spans a broad clinical spectrum from cold urticaria to NOMID and the often fatal disease AIFEC. Rapid case identification with biomarkers like elevated serum IL-18 concentrations and early intervention with targeted immunomodulatory therapies are key strategies to improving outcomes for AIFEC patients.

http://ift.tt/2iCnSwR

Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective

Purpose of review: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU. Recent findings: Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients. Evidence from clinical trials and experience from daily clinical practice suggest that the use of omalizumab in patients with CSU who have inadequate response to H1-antihistamines remains challenging. Summary: Based on current international guidelines, omalizumab labelling information and our experience in clinical practice, we provide treatment recommendations regarding the use of omalizumab in patients with CSU. These include: optimal treatment duration, the use of concomitant antihistamine therapy, the definition and management of disease relapse after treatment, and the management of patients with late or no response to treatment.

http://ift.tt/2iCnSgl

Comparing hemophagocytic lymphohistiocytosis in pediatric and adult patients

Purpose of review: Hemophagocytic lymphohistiocytosis (HLH) has long been thought of primarily as a pediatric disease. However, this syndrome may occur secondary to underlying malignancies, infections, and autoimmune diseases, in adult patients. Here, we seek to highlight similarities and differences between pediatric and adult HLH, knowledge gaps, and areas of active research. Recent findings: Malignancy is a more frequent driver of HLH in adults, present in nearly half. Prognosis is poor as compared with nonmalignant HLH. Prognosis in adults is generally worse than pediatric patients, suggesting that age and other comorbid illnesses not surprisingly affect the outcome of HLH. Diagnostic and treatment approaches are more variable in adults, likely contributing to poorer outcomes. The frequency of mutations in HLH-causing genes is higher than had been anticipated in adults, although with a higher frequency of uniallelic and hypomorphic mutations than in children. Summary: Optimizing diagnostic criteria for earlier detection may benefit both children and adults. Standardizing treatment approaches in adults will be more difficult because of the variability in triggering illnesses, but a more standardized or algorithmic approach will likely be beneficial. More research into the role of uniallelic and hypomorphic mutations in adults is necessary, to understand treatment and prognostic implications.

http://ift.tt/2izre3t

Inherited and acquired clinical phenotypes associated with neuroendocrine tumors

Purpose of review: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. Recent findings: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel–Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs) arising in other immunocompromised states. Of all primary immune deficiency diseases, NETs appear to be unique to XHIGM patients. Outcomes for XHIGM patients with NETs is poor, and the mechanism behind this association remains unclear. In secondary immune deficiency states, NET occurrences were primarily in patients with HIV or AIDS, the autoimmune disease systemic lupus erythematosus and solid organ transplant recipients. Gastroenteropancreatic NETs were most frequent in XHIGM patients, whereas nongastroenteropancreatic–NETs, like Merkel cell carcinoma and small-cell lung carcinoma, affected HIV/AIDS patients. Possible mechanisms as to the nature of these associations are discussed, including chronic infections and inflammation, and CD40–CD40L interactions. Many questions remain, and further studies are needed to clarify the predisposition of patients with XHIGM to the development of NETs. Given that many of these patients present late in their disease state and have poor outcomes, it is imperative to keep a high index of suspicion at the advent of early signs and symptoms. Regular monitoring with laboratory or imaging studies, including tumor markers, may be warranted, for which further studies are needed. Summary: Of all primary immunodeficiency diseases, NETs appear to be unique to XHIGM, and the mechanism behind this association remains unclear. Outcome for XHIGM patients with NETs is poor, and it is imperative to keep a high index of suspicion at the advent of early signs and symptoms.

http://ift.tt/2izSKOo

Approaches to the removal of T-lymphocytes to minimize graft-versus-host disease in patients with primary immunodeficiencies who do not have a matched sibling donor

Purpose of review: Since the advent of T-lymphocyte depletion in hematopoietic stem cell transplantation (HSCT) for primary immunodeficiency, survival following this procedure has remained poor compared to results when using matched sibling or matched unrelated donors, over the last 40 years. However, three new techniques are radically altering the approach to HSCT for those with no matched donor, particularly those with primary immunodeficiencies which are not severe combined immunodeficiency. Recent findings: Three main techniques of T-lymphocyte depletion are altering donor choice for patients with primary immunodeficiencies and have improved transplant survival for primary immunodeficiencies to over 90%, equivalent to that for matched sibling and matched unrelated donor transplants. CD3+ T cell receptor (TCR)αβ+ CD19+ depletion, CD45RA depletion and use of posttransplant cyclophosphamide give similar overall survival of 90%, although viral reactivation remains a concern. Further modification of CD3+ TCRαβ+ CD19+ depletion by adding back inducible caspase-9 suicide gene-modified CD3+ TCRαβ+ T-lymphocytes may further improve outcomes for patients with systemic viral infection. Summary: Over the last 5 years, the outcomes of HSCT using new T-lymphocyte depletion methods have improved to the extent that they are equivalent to outcomes of matched sibling donors and may be preferred in the absence of a fully matched sibling donor, over an unrelated donor to reduce the risk of graft versus host disease.

http://ift.tt/2izSJdi

The role of regulatory B cells in allergen immunotherapy

Purpose of review: Allergen immunotherapy (AIT) is currently the only curative treatment available for allergic diseases, and has been used in clinical practice for over a century. Induction and maintenance of immune tolerance to nonhazardous environmental and self-antigens is essential to maintain homeostasis and prevent chronic inflammation. Regulatory B (BREG) cells are immunoregulatory cells that protect against chronic inflammatory responses primarily through production of anti-inflammatory cytokines such as IL-10, transforming growth factor-β, and IL-35. The importance of BREG cells has been extensively demonstrated in the context of autoimmune diseases. Data showing their role in the regulation of allergic responses are slowly accumulating. This review summarizes recent findings relevant to the topic of BREG cells and their potential role in AIT. Recent findings: BREG cells support AIT in models of allergic airway inflammation and intestinal inflammation through induction of regulatory T (TREG) cells. In humans BREG frequency increases during venom immunotherapy while the phenotype of allergen-specific B cells changes. Mechanisms of BREG-mediated tolerance to allergens include IL-10-mediated suppression of effector T cell, including TH2 responses, induction of TREG cells, IL-10-mediated inhibition of Dendritic cell maturation, modulation of T follicular helper responses, and production of anti-inflammatory IgG4 antibodies. Summary: Current evidence supports a potential role for BREG cells in induction and maintenance of allergen tolerance during AIT. A better understanding of the role of B cells and BREG cells in AIT could open potential new windows for developing targeted therapies specifically focused on promoting BREG responses during AIT.

http://ift.tt/2izEBAS

Whole exome sequencing in inborn errors of immunity: use the power but mind the limits

Purpose of review: Next-generation sequencing, especially whole exome sequencing (WES), has revolutionized the molecular diagnosis of inborn errors of immunity. This review summarizes the generation and analysis of next-generation sequencing data. Recent findings: The focus is on prioritizing strategies for unveiling the potential disease-causing variant. We also highlighted oversights and imperfections of WES and targeted panel sequencing, as well as the need for functional validation. Summary: The information is crucial for a judicious use of WES by researchers, but even more so by the clinical immunologist.

http://ift.tt/2izEx46

A history into genetic and epigenetic evolution of food tolerance: how humanity rapidly evolved by drinking milk and eating wheat

Purpose of review: Human exposure to wheat and milk is almost global worldwide. Yet the introduction of milk and wheat is very recent (5000–10 000 years) when compared to the human evolution. The last 4 decades have seen a rise in food allergy and food intolerance to milk and wheat. Often described as plurifactorial, the cause of allergic diseases is the result from an interplay between genetic predisposition and epigenetic in the context of environmental changes. Recent findings: Genetic and epigenetic understanding and their contribution to allergy or other antigen-driven diseases have considerably advanced in the last few years. Yet, environmental factors are also quite difficult to identify and associate with disease risk. Can we rethink our old findings and learn from human history and recent genetic studies? Summary: More than one million years separate Homo habilis to today's mankind, more than 1 million years to develop abilities to obtain food by foraging in diverse environments. One million year to adjust and fine-tune our genetic code and adapt; and only 1% of this time, 10 000 years, to face the three biggest revolutions of the human kind: the agricultural revolution, the industrial revolution and the postindustrial revolution. With big and rapid environmental changes come adaptation but with no time for fine-tuning. Today tolerance and adverse reactions to food may be a testimony of adaptation successes and mistakes.

http://ift.tt/2iAtBD2

Modified Z-palatoplasty with one-layer closure in one-stage multilevel surgery for severe obstructive sleep apnea

The meticulous two-layer closure is a step to complete the modified Z-palatoplasty, which has been reported to serve as an effective element in multilevel sleep surgery for patients with severe obstructive sleep apnea, especially with Friedman anatomical stages II and III diseases. A single layer closure—the suture closure as originally described in uvulopalatopharyngoplasty by Fujita et al., is an alternative of the two-layer closure, featured by simplicity while its efficacy has not been completely proved in patients with severe obstructive sleep apnea.

http://ift.tt/2gFnXLZ

Depressive symptoms, depression, and the effect of biologic therapy among patients in Psoriasis Longitudinal Assessment and Registry (PSOLAR)

Patients with psoriasis are at an increased risk for depression. However, the impact of treatment on this risk is unclear.

http://ift.tt/2leaaRz

Rare cause of periorbital and eyelids lesions: discoid lupus erythematosus misdiagnosed as allergy

We present a rare case of discoid lupus erythematous (DLE) that clinically presented with eyelid-only involvement.

http://ift.tt/2yMCUnu

Developing Control Algorithms of a Voluntary Cough for an Artificial Bioengineered Larynx Using Surface Electromyography of Chest Muscles: A Prospective Cohort Study

Abstract

Objective

This prospective cohort study investigates the prediction of a voluntary cough using surface electromyography (EMG) of intercostal and diaphragm muscles, in order to develop control algorithms for an EMG controlled artificial larynx.

Setting

The Ear Institute, London.

Main outcome measures

EMG onset compared to voluntary cough exhalation onset and to 100ms (to give the artificial larynx the time to close the bioengineered vocal cords) before voluntary cough exhalation onset, in twelve healthy participants.

Results

In the 189 EMG of intercostal muscle detected voluntary coughs, 172 coughs (91% CI 70-112) were detected before onset of cough exhalation and 128 coughs (67.6% CI 33.7-101.7) 100ms before onset of cough exhalation. In the 158 EMG of diaphragm muscle detected voluntary coughs, 149 coughs (94.3% CI 76.3-112.3) were detected before onset of cough exhalation and 102 coughs (64.6% CI 26.6-102.6) 100ms before onset of cough exhalation. More coughs were detected before onset of cough exhalation when combining EMG activity of intercostal and diaphragm muscles and comparing this to intercostal muscle activity alone (183 coughs [96.8% CI 83.8-109.8] v 172 coughs, p=0.0294). When comparing the mentioned combination to diaphragm muscle activity alone, the higher percentage detected coughs before cough exhalation onset was not found to be significant (183 coughs v 149 coughs, p=0.295). In addition, more coughs were detected 100ms before onset of cough exhalation with the mentioned combination of EMG activity and comparing this to intercostal muscles alone (149 coughs [78.8% CI 48.8-108.8] v 128 coughs, p=0.0198) and to diaphragm muscles alone (149 coughs v 102 coughs, p=0.0038).

Conclusions

Most voluntary coughs can be predicted based on combined EMG signals of intercostal and diaphragm muscles and therefore these two muscle groups will be useful in controlling the bioengineered vocal cords within the artificial larynx during a voluntary cough.

This article is protected by copyright. All rights reserved.

http://ift.tt/2yNmVqS

Needs and preferences of patients with head and neck cancer in integrated care

Abstract

Objectives

Incorporation of patients' perspectives in daily practice is necessary to adapt care to users' needs. However, information on patients' needs and preferences for integrated care is lacking. The aim was to explore these needs and preferences, taking patients with head and neck cancer (HNC) as example, to adapt current integrated care to be more patient-centered.

Design

Semi-structured interviews were held with current and former patients and chairmen of patient associations. Relevant needs and preferences were identified and categorized using the eight-dimension Picker model of patient-centered care.

Setting

Integrated HNC in the Netherlands.

Participants

HNC-patients and chairmen of two Dutch HNC-patient associations.

Main outcome measures

Patients' needs and preferences of integrated HNC care categorized according the Picker model.

Results

A total of 34 themes of needs and preferences were identified, by 14 HNC-patients or their delegates, using the Picker dimensions. Themes often emerged were: personalization of healthcare regarding patients values, clear insight into the healthcare process at organizational level, use of personalized communication, education and information that meets patients requirements, adequate involvement of allied health professionals for physical support, more attention to the impact of HNC and its treatment, adequate involvement of family and friends, adequate general practitioner involvement in the after care, and waiting time reduction.

Conclusions

Monitoring the identified themes in integrated HNC care, fitting in the Picker model, will enable us to respond better to the needs and preferences of patients and patient-centered care in oncological care can be enhanced.

This article is protected by copyright. All rights reserved.

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Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Sujana Gottumukkala, Nhat-Long Pham, Baran Sumer, Larry Myers, John Truelson, Lucien Nedzi, Saad Khan, Randy Hughes, David J. Sher
PurposeTo determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma.MethodsRetrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with definitive or adjuvant radiation to the primary site and ipsilateral neck between 2005 and 2015. Contralateral nodal failure, locoregional recurrence, distant metastasis, and overall survival were calculated using actuarial and/or cumulative incidence statistics.ResultsAt last follow-up, contralateral nodal failure was only observed in 1 patient (3%) with N1 disease. At median follow-up of 34 months for surviving patients, the 3-year overall survival probability was 87%, and the 3 year cumulative incidences of locoregional failure and distant metastasis were 6.5% and 7.2%, respectively. No disease-free patient was permanently gastrostomy-dependent.ConclusionIpsilateral radiation treatment with IMRT is effective in node-positive patients with well-lateralized tonsillar cancer, resulting in a low risk of contralateral regional recurrence, even in patients with N2b disease.



http://ift.tt/2zPeKcn

Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis

Publication date: Available online 25 October 2017
Source:Clinical Immunology
Author(s): Yusei Miyazaki, Masaaki Niino, Eri Takahashi, Masako Suzuki, Masanori Mizuno, Shin Hisahara, Toshiyuki Fukazawa, Itaru Amino, Fumihito Nakano, Masakazu Nakamura, Sachiko Akimoto, Naoya Minami, Naoto Fujiki, Shizuki Doi, Shun Shimohama, Yasuo Terayama, Seiji Kikuchi
Patients with multiple sclerosis (MS) who are treated with fingolimod have an increased proportion of transitional B cells in the circulation, but the underlying mechanism is not known. We hypothesized that B cell-activating factor of the tumor necrosis factor family (BAFF) is involved in the process. Compared with healthy controls and untreated MS patients, fingolimod-treated MS patients had significantly higher serum concentrations of BAFF, which positively correlated with the proportions and the absolute numbers of transitional B cells in blood. Despite the elevated concentrations of BAFF in fingolimod-treated MS patients, serum levels of soluble transmembrane activator and calcium-modulating cyclophilin ligand interactor, and B cell maturation antigen were not elevated. Our results show that fingolimod induces BAFF in the circulation and expands transitional B cells, but does not activate memory B cells or plasma cells in MS, which is favorable for the treatment of this disease.

Graphical abstract

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Therapeutic administration of bone marrow-derived mesenchymal stromal cells reduces airway inflammation without upregulating Tregs in experimental asthma

Abstract

Background

Prophylactic administration of mesenchymal stromal cells (MSCs) derived from adipose (AD-MSC) and bone marrow tissue (BM-MSC) in ovalbumin-induced asthma hinders inflammation in a Treg-dependent manner. It is uncertain whether MSCs act through Tregs when inflammation is already established in asthma induced by a clinically relevant allergen.

Objective

Evaluate the effect of therapeutic administration of MSCs on inflammation and Treg cells in house dust mite (HDM)-induced asthma.

Methods

BM-MSCs and AD-MSCs were administered intratracheally to C57BL/6 mice 1 day after the last HDM challenge. Lung function, remodeling and parenchymal inflammation, were assayed 3 or 7 days after MSCs treatment, through invasive plethysmography and histology, respectively. Bronchoalveolar lavage fluid (BALF) and mediastinal lymph nodes (mLNs) were assessed for lymphocyte phenotyping by flow cytometry. MSCs were studied regarding their potential to induce Treg cells from primed and unprimed lymphocytes in vitro.

Results

BM-MSCs, but not AD-MSCs, reduced lung influx of eosinophils and B cells and increased IL-10 levels in HDM-challenged mice. Neither BM-MSCs nor AD-MSCs reduced lung parenchymal inflammation, airway hyperresponsiveness or mucus hypersecretion. BM- and AD-MSCs did not upregulate Treg cell counts within the airways and mLNs, but BM-MSCs decreased the pro-inflammatory profile of alveolar macrophages. Co-culture of BM-MSCs and AD-MSCs with allergen-stimulated lymphocytes reduced Treg cell counts in a cell to cell contact independent manner, although co-culture of both MSCs with unprimed lymphocytes upregulated Treg cell counts.

Conclusions

MSCs therapeutically administered exert anti-inflammatory effects in the airway of HDM-challenged mice, but do not ameliorate lung function or remodeling. Although MSC pre-treatment can increase Treg cell numbers, it is highly unlikely that the MSCs will induce Treg cell expansion when lymphocytes are allergenically primed in an established lung inflammation.

This article is protected by copyright. All rights reserved.

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Eosinophil persistence in vivo and sustained viability ex vivo in response to respiratory challenge with fungal allergens

Abstract

Background

Eosinophils are immunomodulatory leukocytes that contribute to the pathogenesis of Th2 driven asthma and allergic lung diseases.

Objective

Our goal was to identify unique properties of eosinophils recruited to the lungs and airways of mice in response to challenge with asthma-associated fungal allergens.

Methods

Mice were challenged intranasally on days 0, 3 and 6 with a filtrate of Alternaria alternata. Recruited eosinophils were enumerated in bronchoalveolar lavage fluid. Eosinophils were also isolated from lungs of mice sensitized and challenged with Aspergillus fumigatus and evaluated ex vivo in tissue culture.

Results

Eosinophils persist in the airways for several weeks in response to brief provocation with A. alternata in wild-type, Gm-csf- and eotaxin-1-gene-deleted mice, while eosinophils are recruited but do not persist in the absence of IL-13. Eosinophils isolated from the lungs A. alternata-challenged mice are cytokine-enriched compared to those from IL5tg mice, including 800-fold higher levels of eotaxin-1. Furthermore, eosinophils from the lungs and spleen of fungal-challenged wild-type are capable of prolonged survival ex vivo, in contrast to eosinophils from both un-treated and fungal-allergen challenged IL5tg mice, which undergo rapid demise in the absence of exogenous cytokine support. TNFα (but not IL5, IL-3, eotaxin-1 or GM-CSF) was detected in supernatants of ex vivo eosinophil cultures from the lungs of fungal-allergen challenged wild-type mice. However, neither TNFα gene-deletion nor anti-TNFα neutralizing antibodies had any impact sustained eosinophil survival ex vivo.

Conclusion and Clinical Relevance

Eosinophils are phenotypically and functionally heterogeneous. As shown here, eosinophils from fungal-allergen challenged wild-type mice maintain a distinct cytokine profile, and, unlike eosinophils isolated from IL5tg mice, they survive ex vivo in the absence of exogenous pro-survival cytokine support. As treatments for asthma currently in development focus on limiting eosinophil viability via strategic cytokine blockade, the molecular mechanisms underlying differential survival merit further investigation.

This article is protected by copyright. All rights reserved.

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Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

Abstract

In this paper we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2016. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis and clinical allergy are all covered.

This article is protected by copyright. All rights reserved.

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Penile Chancres in a Man Who Has Sex With Men

This case report describes the clinical and serologic evolution of multiple penile chancres in a man who has sex with men.

http://ift.tt/2xmIdsl

Sun Protection Policies in Elementary Schools in California

This study examines sun safety policies and deviation from a 2005-disseminated sample policy among member districts of the California School Boards Association.

http://ift.tt/2zOVX0E

Tanning Salon Compliance in States With Legislation to Protect Youth Access

This cross-sectional telephone survey investigates compliance rates in the 42 states and the District of Columbia with legislation restricting tanning bed use in minors.

http://ift.tt/2xnRW1G

An Annular Eruption on the Trunk and Limbs

An otherwise healthy man in his 20s presented with a 2-month history of itchy skin lesions on his trunk, arms, and groin with no associated extracutaneous symptoms. What is your diagnosis?

http://ift.tt/2zPUKGw

Immunometabolism, pregnancy, and nutrition

Abstract

The emerging field of immunometabolism has substantially progressed over the last years and provided pivotal insights into distinct metabolic regulators and reprogramming pathways of immune cell populations in various immunological settings. However, insights into immunometabolic reprogramming in the context of reproduction are still enigmatic. During pregnancy, the maternal immune system needs to actively adapt to the presence of the fetal antigens, i.e., by functional modifications of distinct innate immune cell subsets, the generation of regulatory T cells, and the suppression of an anti-fetal effector T cell response. Considering that metabolic pathways have been shown to affect the functional role of such immune cells in a number of settings, we here review the potential role of immunometabolism with regard to the molecular and cellular mechanisms necessary for successful reproduction. Since immunometabolism holds the potential for a therapeutic approach to alter the course of immune diseases, we further highlight how a targeted metabolic reprogramming of immune cells may be triggered by maternal anthropometric or nutritional aspects.

http://ift.tt/2yNCZcb

Emerging roles of innate lymphoid cells in inflammatory diseases: clinical implications

Abstract

Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and non-allergic inflammatory diseases due to their location at barrier surfaces within the airways, gut and skin and they respond to cytokines produced by activated cells in their local environment. ILCs contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. In recent years, these cells have been extensively characterized and their role in animal models of disease has been investigated. Data to translate the relevance of ILCs in human pathology, and the potential role of ILCs in diagnosis, as biomarkers and/or as future treatment targets are also emerging.

This review, produced by a task force of the Immunology Section of the European Academy of Allergy and Clinical Immunology (EAACI) encompassing clinicians and researchers, highlights the role of ILCs in human allergic and non-allergic diseases in the airways, gastrointestinal tract and skin, with a focus on new insights into clinical implications, therapeutic options and future research opportunities.

This article is protected by copyright. All rights reserved.

http://ift.tt/2yNQLLQ

Do geographic differences or socioeconomic disparities affect survival in sinonasal squamous cell carcinoma?

Background

Squamous cell carcinoma (SCC) is the most common malignancy in the sinonasal tract. We present the first population-based analysis that examines geographic differences in demographic and clinical characteristics, socioeconomic factors, treatment modality, and disease-specific survival (DSS) of this entity.

Methods

All cases of sinonasal squamous cell carcinoma (SNSCC) were queried using the U.S. Surveillance, Epidemiology, and End Results (SEER) registry from 1973 to 2013. Patients were stratified by geographic location and characteristics such as demographics (age, gender, race, metropolitan/nonmetropolitan status, and income), stage at diagnosis, and treatment modality. Survival data were generated using Kaplan-Meier regression analysis.

Results

In total, 6094 patients were identified; 15.3% were from the East, 16.3% from the Midwest, 19.3% from the South, and 49.1% from the West. Patients from the South were younger (p < 0.001). The South had the highest proportion of patients who were black (p < 0.001), lived in nonmetropolitan areas (p < 0.001), and presented with localized disease (p < 0.001). Southern patients also had the lowest median income (p < 0.05), and were least likely to be treated with both surgery and radiotherapy (p < 0.001). The South exhibited the lowest 20-year DSS compared to all other regions (p < 0.001).

Conclusion

SNSCC patients from the South had the poorest long-term DSS, despite being most likely to present with localized disease. The South had the highest proportion of patients who were black, resided in rural or urban towns, had the lowest median income, and did not receive standard combination therapy, compared to the East, Midwest, and West.

http://ift.tt/2yKB8Wm

Survival in patients with parotid gland carcinoma – Results of a multi-center study

Publication date: Available online 24 October 2017
Source:American Journal of Otolaryngology
Author(s): Keigo Honda, Shinzo Tanaka, Shogo Shinohara, Ryo Asato, Hisanobu Tamaki, Toshiki Maetani, Ichiro Tateya, Morimasa Kitamura, Shinji Takebayashi, Kazuyuki Ichimaru, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Masanobu Mizuta, Koichiro Yamada, Koichi Omori
BackgroundParotid gland carcinoma is a rare malignancy, comprising only 1–4% of head and neck carcinomas; therefore, it is difficult for a single institution to perform meaningful analysis on its clinical characteristics. The aim of this study was to update the clinical knowledge of this rare disease by a multi-center approach.MethodsThe study was conducted by the Kyoto University Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group (Kyoto-HNOG). A total of 195 patients with parotid gland carcinoma who had been surgically treated with curative intent between 2006 and 2015 were retrospectively reviewed. Clinical results including overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), local control rate (LCR), regional control rate (RCR), and distant metastasis-free survival (DMFS) were estimated. Univariate and multivariate analyses were performed to identify prognostic factors.ResultsThe median patient age was 63years old (range 9–93years), and the median observation period was 39months. The OS, DFS, DSS, LCR, RCR, and DMFS at 3years were 85%, 74%, 89%, 92%, 88%, and 87%, respectively. Univariate analysis showed age over 74, T4, N+, preoperative facial palsy, high grade histology, perineural invasion, and vascular invasion were associated with poor OS. N+ and high grade histology were independent factors in multivariate analysis. In subgroup analysis, postoperative radiotherapy was associated with better OS in high risk patients.ConclusionNodal metastases and high grade histology are important negative prognostic factors for OS. Postoperative radiotherapy is recommended in patients with advanced high grade carcinoma.



http://ift.tt/2yJSxOY

The malleus cap: Anatomic description of cartilage of the lateral process of the malleus

Publication date: Available online 25 October 2017
Source:American Journal of Otolaryngology
Author(s): Elias Michaelides, Ankit Kansal, Sara Rutter, Christopher A. Schutt
PurposeTo anatomically describe a cartilaginous cap attached to the lateral process of the malleus.Study Design.Histologic and gross anatomic review.MethodsTwenty temporal bones were histologically reviewed. The anatomical relationship between the tympanic membrane and malleus was then defined at the level of the lateral process of the malleus and the long process of the malleus. Separately, gross evaluation of these levels at the macroscopic level was undertaken through endoscopic imaging in five subjects.ResultsAll temporal bones reviewed revealed the presence of a cartilaginous cap articulating between the tympanic membrane and the lateral process of the malleus. The cartilaginous cap was also readily identifiable in gross evaluation of the tympanic membrane from views lateral and medial to the tympanic membrane during endoscopic evaluation.ConclusionThe cartilaginous cap of the lateral process of the malleus is an important and reliable anatomical structure of the middle ear that has not previously been described. Through knowledge of the structure surgeons may exploit its presence by creating a cleavage plane between the cartilaginous cap and the malleus during tympanoplasty, possibly allowing for safer and more efficient surgery.



http://ift.tt/2gIrFrC

A Study of Apatinib Plus Radiotherapy and S-1 for Treatment of Refractory or Metastatic Esophageal Squamous Cell Carcinoma

Condition:   Refractory or Metastatic Esophageal Squamous Cell Carcinoma
Interventions:   Combination Product: apatinib S-1 radiotherapy;   Combination Product: S-1 radiotherapy
Sponsor:   Hebei Medical University Fourth Hospital
Not yet recruiting

http://ift.tt/2yMUiIO

The Evaluation of Simplified Predictive Intubation Difficulty Score.

Conditions:   Head and Neck Disorder;   Difficult Intubation;   Facial Deformity
Intervention:  
Sponsors:   Maltepe University;   Sisli Etfal Training & Research Hospital
Recruiting

http://ift.tt/2yPsZj7

Phase Ⅲ Trial Adjuvant Chemotherapy in Patients With Locoregionally Advanced NPC

Condition:   Nasopharyngeal Carcinoma
Interventions:   Drug: CCRT+GP;   Drug: CCRT+PF;   Radiation: Concurrent chemoradiotherapy
Sponsor:   Sun Yat-sen University
Not yet recruiting

http://ift.tt/2yMUgAG

Airway Protective Mechanisms in PD (R01)

Condition:   Parkinson Disease
Interventions:   Drug: Capsaicin;   Device: Resistive respiratory loads;   Other: Event-related evoked potential using electroencephalography (EEG).;   Procedure: Fluoroscopic swallow evaluation
Sponsors:   University of Florida;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

http://ift.tt/2yPGnUi

Intrauterine device embedded in omentum of postpartum patient with a markedly retroverted uterus: a case report

The intrauterine device is a popular form of long-acting reversible contraception. Although generally safe, one of the most serious complications of intrauterine device use is uterine perforation. Risk factors...

http://ift.tt/2i4nTFL

Treatment of orofacial granulomatosis: a case report

Orofacial granulomatosis is a relatively recent term coined by Wiesenfield et al. in 1985 to define granulomatous lesions of oral mucosa without intestinal involvement. When it presents in a triad encompassing fa...

http://ift.tt/2gE4f3d

Hydroxyethyl starch 130/0.4 versus crystalloid co-loading during general anesthesia induction: a randomized controlled trial

Abstract

Purpose

Hypotension and decreased cardiac output (CO) are common adverse effects during anesthesia induction depending on the patient's pre-anesthetic cardiac condition. The aim of this study was to assess the ability of hydroxyethyl starch (HES) 130/0.4 to prevent hypotension and decreased CO during the induction of general anesthesia.

Methods

Ninety patients undergoing laparoscopic surgery were randomly divided into a HES group and a crystalloid group. Following the insertion of an intravenous line, fluid was administered to each patient at a rate of 25 ml/min using either crystalloid or HES 130/0.4. Five minutes after the initiation of fluid loading, anesthesia was induced using propofol (1.5 mg/kg), rocuronium (0.9 mg/kg), and remifentanil (0.3 mcg/kg/min). Tracheal intubation was performed 5 min after the induction of anesthesia. Following tracheal intubation, general anesthesia was maintained using remifentanil and sevoflurane. Non-invasive blood pressure (BP) level was measured at 1-min intervals and CO was measured continuously using electrical cardiometry from the start of fluid loading until 5 min after tracheal intubation.

Results

The number of patients with hypotension (systolic BP < 90 mmHg or 80% of baseline) was significantly lower in the HES group (p < 0.001) than in the crystalloid group. Patients in the HES group showed smaller CO decreases than did patients in the crystalloid group (p < 0.001). The Kaplan–Meier method showed a lower incidence and significantly slower onset of hypotension in the HES group (p = 0.009). Multivariate logistic regression models indicated that the use of HES is an independent factor for the prevention of both hypotension and decreased CO (below 85% of baseline; p < 0.005 for both).

Conclusions

Co-loading using HES 130/0.4 prevented hypotension and decreased CO during general anesthesia induction.

http://ift.tt/2h7vX8Y

Cat exposure in early life decreases asthma risk from the 17q21 high-risk variant

Publication date: Available online 25 October 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Jakob Stokholm, Bo L. Chawes, Nadja Vissing, Klaus Bønnelykke, Hans Bisgaard
BackgroundEarly-life exposure to cats and dogs has shown diverging associations with childhood asthma risk, and gene-environment interaction is one possible explanation.ObjectivesWe investigated interactions between cat and dog exposure and single nucleotide polymorphism rs7216389 variants in the chromosome 17q21 locus, the strongest known genetic risk factor for childhood asthma.MethodsGenotyping was performed in 377 children from the at-risk Copenhagen Prospective Studies on Asthma in Childhood2000. The primary end point was the development of asthma until age 12 years. The secondary end point was the number of episodes with pneumonia and bronchiolitis from 0 to 3 years of age. Exposures included cat and dog ownership from birth and cat and dog allergen levels in bedding at age 1 year. Replication was performed in the unselected COPSAC2010 cohort with follow-up until 5 years of age.ResultsCat and/or dog exposure from birth was associated with a lower prevalence of asthma among children with the rs7216389 high-risk TT genotype (adjusted hazard ratio, 0.16; 95% CI, 0.04-0.71; P = .015), with no effect in those with the CC/CT genotype (adjusted P = .283), demonstrating interaction between cat and dog exposure and the rs7216389 genotype (adjusted P = .044). Cat allergen levels were inversely associated with asthma development in children with the TT genotype (adjusted hazard ratio, 0.83; 95% CI, 0.71-0.97; P = .022), supporting the cat–rs7216389 genotype interaction (adjusted P = .008). Dog allergen exposure did not show such interaction. Furthermore, the TT genotype was associated with higher risk of pneumonia and bronchiolitis, and this increased risk was likewise decreased in children exposed to cat. Replication showed similar effects on asthma risk.ConclusionThe observed gene-environment interaction suggests a role of early-life exposure, especially to cat, for attenuating the risk of childhood asthma, pneumonia, and bronchiolitis in genetically susceptible subjects.

Graphical abstract

http://ift.tt/2yPd04J

Recent progress of retroauricular robotic thyroidectomy with the new surgical robotic system

Objective

Previously, we have reported the feasibility of retroauricular (RA) robotic thyroidectomy. Despite its promising surgical outcomes, there were certain intrinsic mechanical limitations inherent to the da Vinci Si System (Intuitive Surgical, Sunnyvale, California, U.S.A.). Since the advent of an upgraded model, the Xi System (Intuitive Surgical), we have actively incorporated the new model into performing RA thyroidectomy. Here, we intend to verify the feasibility of RA robotic thyroidectomy using the new da Vinci Xi System (Intuitive Surgical) with comparison of the former Si-applied surgery (Intuitive Surgical).

Study Design

Comparative analysis.

Methods

There were total 165 consecutive patients who received RA robotic thyroidectomy from January 2013 to February 2016. The patients were divided into two groups: Si group (n = 125) and Xi group (n = 40). Perioperative and treatment outcomes were compared and analyzed.

Results

Compared with the previous system, new da Vinci Xi system (Intuitive Surgical) enabled insertion of an extra third robotic instrumental arm. Unlike the previous robotic surgical technique, the robotic dissection could be initiated immediately after the establishment of working space and the resulting total operation time could be significantly decreased. There was no difference in the surgical completeness, as confirmed by postoperative thyroglobulin levels. Additionally, flexed EndoWrist (Intuitive Surgical) instruments equipped with the Erbe (Erbe USA Inc., Marietta, Georgia, U.S.A.) system could be mounted, which further facilitated the operation. There were no significant differences in postoperative complications between the two groups.

Conclusion

The RA robotic thyroidectomy with the new Xi System (Intuitive Surgical) can greatly facilitate the robotic surgery with comparable or improved surgical outcomes. Its application is expected to open up a new era of robotic neck surgery.

Level of Evidence

4. Laryngoscope, 2017

http://ift.tt/2yKK7Hg

The safety and efficacy of powered intracapsular tonsillectomy in children: A meta-analysis

Objectives

We performed a systemic review and meta-analysis regarding the postoperative pain, perioperative, and postoperative morbidity of powered intracapsular tonsillectomy and adenoidectomy (PITA) using a microdebrider as a method of tonsillectomy.

Data Sources

Five databases (PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials) in their entirety through March 2017.

Review Methods

We included studies in which there was a comparison between groups of patients who underwent PITA (PITA group) and those who had extracapsular tonsillectomy (control group). Articles assessing effects of PITA in the pediatric patient were systemically and independently reviewed by two researchers. The outcomes of interest were intraoperative morbidity (operative time and bleeding), postoperative morbidity (postoperative pain, recovery time, tonsil regrowth, and postoperative bleeding rate), and improvement of sleep breath disorder (apnea-hypopnea index [AHI] and symptomatic scores).

Results

PITA did not significantly increase operative time or intraoperative blood loss. With PITA, there was significantly decreased postoperative pain, amount of analgesia, time to resumption of normal diet and activity, and incidence of postoperative admissions (due to dehydration or postoperative bleeding control) compared to those of the control group. In contrast, the incidence of postoperative tonsil regrowth was statistically higher in the PITA group than in the control group. The PITA improved AHI and obstructive sleep apnea 18-item questionnaire scores significantly, which were similar with the control group.

Conclusions

With regard to intraoperative morbidity and postoperative morbidity, PITA is a safe procedure. However, there are high levels of heterogeneity with regard to several measured parameters. Therefore, further large, well-designed trials are required to substantiate our findings. Laryngoscope, 2017

http://ift.tt/2lfxuOO

Nose blowing after endoscopic sinus surgery does not adversely affect outcomes

Objective

Patients frequently are advised to abstain from nose blowing following endoscopic sinus surgery (ESS), despite a lack of evidence supporting this recommendation. This randomized study assessed whether nose blowing in the first postoperative week affects subjective and objective clinical outcomes.

Methods

Forty patients undergoing ESS were randomized into an interventional arm in which patients blew their nose at least twice daily for the first 7 postoperative days, or a control arm in which patients refrained from nose blowing. All patients were allowed to blow their nose after 7 days. The frequency and degree of epistaxis was documented by daily diary and visual analog scale (VAS). At 1 and 4 weeks postoperatively, Nasal Obstruction Symptom Evaluation (NOSE) and Sino-Nasal Outcome Test-22 (SNOT-22) were collected, and endoscopies were recorded for blinded Lund-Kennedy scale scoring.

Results

There were no differences between the two groups in terms of frequency and duration of bleeding events, VAS epistaxis scores, SNOT-22 scores, and NOSE scores at every postoperative timepoint. Lund-Kennedy scores also were similar at the 1-week (P = 0.0762) and 4-week (P = 0.2340) postoperative visits, but the nose-blowing group had improved nasal discharge subscores at the first (P = 0.0075) and second (P = 0.0298) postoperative visits.

Conclusion

Nose blowing after ESS does not appear to measurably improve symptoms of nasal congestion or general sinonasal quality of life, nor does it seem to adversely affect the frequency or severity of postoperative epistaxis during the first postoperative week. Judicious nose blowing may be permissible immediately after uncomplicated ESS.

Level of Evidence

1b. Laryngoscope, 2017

http://ift.tt/2yKvL9S

Health disparities among adults with voice problems in the United States

Objective

To assess differences in access to care and healthcare utilization among adults who reported voice problems in 2012.

Study Design

Cross-sectional study.

Methods

The 2012 National Health Interview Survey was utilized to evaluate adults who had a "voice problem in the past 12 months." Multivariate analyses determined the influence of sociodemographic variables on the prevalence of voice problems in adults and access to care.

Results

Among 243 million adults in the United States, 17.9 ± 0.05 million adults (7.63% ± 0.21%) report experiencing voice problems. After controlling for age, education, income level, geographic region, and health insurance status, African Americans (odds ratio [OR]: 0.83, P < 0.05), Hispanics (OR: 0.61, P < 0.01), and other minorities (OR: 0.69, P < 0.01) had a lower OR for reporting voice problems in the last year relative to white adults. Among adults with voice problems, Hispanics were more likely to delay care because they could not reach a medical office by telephone (OR: 1.85, P < 0.01) and due to long wait times at the doctor's office (OR: 2.04, P < 0.01) compared to white adults. Adults with voice problems who were a racial minority, low income, or had public health insurance were more likely to postpone care because they lacked a mode of transportation.

Conclusion

Targeted programs are necessary to address the health disparities and barriers to care among those who suffer from voice problems.

Level of Evidence

IV. Laryngoscope, 2017

http://ift.tt/2lfhQTH

Response to ‘Healthcare and ecological economics at a crossroads’

Editor—We thank Odefey and colleagues¹ for their thoughtful letter. The authors were appreciative of our article, but were concerned that we did not comprehensively explore issues regarding water use for cleaning reusable anaesthetic equipment. Our article primarily considered the financial costs and carbon footprints associated with processing reusable and single-use anaesthetic equipment.² We did examine all other environmental footprints routinely examined in life cycle assessment, but noted that apart from water use, these footprints were small and varied little between approaches. Most of the water use for the reusable equipment stemmed from the washer loads (70% total water use).

http://ift.tt/2h7KBNB

Survival with disability. Whose life is it, anyway?

Editor—We read with interest the editorial by Dr Lönnqvist entitled "Medical Research and the Ethics of Medical Treatments: Disability-free Survival".¹ The editorial refers to our study, RESCUEicp, that interrogated the effect of secondary decompressive craniectomy in traumatic brain injury (TBI) patients with refractory intracranial hypertension.² The editorial states 'the conclusion to draw is instead that, despite reducing overall mortality, surgery is not associated with any true long-term benefits in this setting; it only increases the number of patients in a vegetative state or suffering serious disability, and should therefore not be used'. We have major concerns about this statement with reference to our study, and with the wider premise that underpins the editorial, and we will address each of these in turn.

http://ift.tt/2zDaP1f

Low end-tidal carbon dioxide as a marker of severe anaesthetic anaphylaxis: the missing piece of the puzzle?

Perioperative anaphylaxis has assumed increased prominence in recent times with the Royal College of Anaesthetists of Great Britain and Ireland focusing on this topic for the 6^th National Audit Project "NAP6".¹ The reporting period for cases has recently closed and as a result analysis from this audit will provide large amounts of data that will help our understanding of the incidence, causes and sequelae of anaphylaxis in 2017.

http://ift.tt/2h8fMZ3

Reply to: Does deep neuromuscular block optimise surgical space better than moderate block?

Editor—We thank the authors¹ for the valuable comments on our paper entitled "Deep neuromuscular block to optimize surgical space conditions during laparoscopic surgery: a systematic review and meta-analysis".²

http://ift.tt/2h769K8

In the November issue

This month's issue is notable for a wealth of articles on various aspects of paediatric anaesthesia, and digital technology in quality and patient safety.

http://ift.tt/2zC4DX7

Healthcare and ecological economics at a crossroads. Response to: financial and environmental costs of reusable and single-use anaesthetic equipment

Water relationships would be simple and linear were they not complicated by all those other ways that human beings are connected with and divided from each other.              —Stanley Crawford

http://ift.tt/2h7gshu

Assessing anaesthesia in rabbits receiving rocuronium. Response to: Effects of arterial load variations on dynamic arterial elastance: an experimental study

Editor—The study published by Monge Garcia and colleagues¹ in the British Journal of Anaesthesia was conducted on 18 rabbits anaesthetized with xylazine and ketamine and paralysed with rocuronium. The authors reported that the study involved procedures that had been approved by the Ethical Committee for Animal Experimentation of the School of Medicine of the University of Cadiz (license 07–9604), conformed to European Ethical Standards (2012/707/EU) and Spanish Law (RD 53/2013) for the care and use of laboratory animals for experimental research, and adhered to relevant aspects of the ARRIVE guidelines. Consequently, we were disappointed to discover that these regulatory bodies, along with the editorial process of the BJA, appear to be satisfied that assessing the animals' physiological responses to a nociceptive stimulus (tail clamping) represents a suitable method for determining adequacy of anaesthesia in animals receiving neuromuscular blocking agents. Putting aside concerns with the reliability of physiological (i.e. cardiovascular), responses as indicators of anaesthetic depth, we question the wisdom of this approach in an animal study primarily aimed at examining the interrelationship of many of the same variables commonly affected by accidental awareness under general anaesthesia.

http://ift.tt/2zC4xPf

Does deep neuromuscular block optimize surgical space better than moderate block?

Editor—We read with great interest the meta-analysis by Bruintjes"]?> and colleagues.¹ We would like to discuss several methodological limitations that may have led this meta-analysis to a wrong conclusion.

http://ift.tt/2zC4uTz

Reply to Clutton and colleagues: assessing anaesthesia in rabbits receiving rocuronium

Editor—Thanks to Clutton and colleagues¹ for their comments about our paper². On behalf of my co-authors, I would like to reply regarding two points raised: (i) the welfare of animals in our research; and (ii) the experimental protocol.

http://ift.tt/2zCLog8

Postoperative conditions after antagonism of neuromuscular blocking agent and extubation without use of a neuromuscular monitor

Editor—We thank Muggleton & Muggleton¹ and Sethi and colleagues² for their interest in our study.³ In that particular study we measured postoperative haemoglobin oxygen saturation in patients whilst not receiving supplemental oxygen by mask after extubation under so called "blinded conditions", that is without the use of a neuromuscular monitor but based solely on clinical signs, after antagonism with either sugammadex or neostigmine.

http://ift.tt/2h7gfuI

Medical research and the ethics of medical treatments: disability-free survival. Reply from the author

Editor—I read with great interest the comments by Menon and colleagues¹ in response to my previous editorial in British Journal of Anaestehsia.² I find their comments very appropriate and level-headed and I have no intention to get into any polemic argument, but would like to clarify a few points:

http://ift.tt/2h9yOhU

Obstetric neuraxial anaesthesia in the context of maternal immune thrombocytopenia: secondary analysis of a retrospective cohort study

Editor—Immune thrombocytopenia (ITP) is an autoimmune condition affecting 1–10 in 10 000 pregnancies.¹ The bleeding risk associated with significant thrombocytopenia poses a challenge peripartum, particularly for placement of neuraxial anaesthesia, where evidence to guide practice remains scant.² Our aim is to describe our experience with neuraxial anaesthesia in the setting of ITP in pregnancy at two tertiary-level academic institutions. The report is a secondary analysis of a retrospective study of pregnant women with ITP at two tertiary-level Canadian academic institutions: Mount Sinai Hospital (MSH), Toronto and McMaster University Medical Centre, Hamilton (MUMC) from January 2000 to August 2014.³ Research ethics board approval was granted at both hospital sites.

http://ift.tt/2zBF1Ka

Hypotonic maintenance i.v. fluids are not appropriate in acutely ill patients. Conclusions can't be extrapolated from healthy volunteers

Editor—A critical aspect in the care of acutely ill patients is the administration of i.v. fluids.¹ Debate exists in the both pediatric and adult literature regarding the optimal sodium composition of i.v. fluids. Our group has advocated for the use of an isotonic solution, such as 0.9% NaCl (154 mEq litre⁻¹), for the prevention of hospital-acquired hyponatraemia, as hypotonic solutions have been associated with a high incidence of hospital-acquired hyponatraemia and neurologic complications in both children and adults.^2–5 Acutely ill patients have numerous physiological and disease related stimuli for vasopressin (AVP) production, which makes virtually all hospitalized patients at risk for hyponatraemia.¹ Concerns against the use of 0.9% NaCl are the potential for developing hypernatraemia, fluid overload and hyperchloraemic acidosis.

http://ift.tt/2zC3cbh